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• Clinical analysis of 16 patients with Clostridium butyricum isolated from blood cultures: A 10-year single-center case series and review of published cases.
  Clostridium butyricum is an anaerobic gram-positive bacillus widely used as a probiotic preparation in Japan. Although generally considered safe, C. butyricum has rarely been isolated from blood cultures, particularly in immunocompromised or medically complex …
  pubmed Yoshinaga S, Watanabe M, Ito H, Hatakeyama S 等 2026 Oct 置信度 0.82
• Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature.
  As the first and dominant life forms on the planet, microorganisms underpin all ecological and organismal systems that drive planetary functioning, ecosystem health, and human wellbeing. Microbial communities are affected by anthropogenic pressures, and some m…
  pubmed Gilbert JA, Scholz AH, Bello MGD, Korsten L 等 2025 置信度 0.82
• Longitudinal clinical impact of dynamic variant re-classification on reproductive decision-making: a 3-year case study.
  The clinical application of sequencing guidelines often yields variants of uncertain significance (VUS), creating profound challenges in prenatal genetic counseling. This study demonstrates the clinical utility and real-world impact of dynamic, longitudinal va…
  pubmed Liu F, Zhou Q, Chenzhang Y, Ju X 等 2026 Aug 11 置信度 0.82
• Lack of leishmania spp. detection in a molecular survey of high-risk domestic cats from the southcentral USA.
  Endemic transmission of cutaneous leishmaniasis, primarily caused by Leishmania (Leishmania) mexicana complex, has become increasingly recognized in the southcentral USA. Veterinary species could play a role in the epidemiology of L. (L.) mexicana in the USA, …
  pubmed Smith RC, Barrantes Murillo DF, Hay-Parker S, Duncan K 等 2026 Aug 置信度 0.82
• Genetic analysis of human adenovirus type 7 circulating in China during 2014-2025.
  Human adenovirus type 7 (HAdV-7) has caused outbreaks of acute respiratory infections (ARIs) among children in multiple countries. This study aimed to investigate the clinical and genetic characteristics of HAdV-7 in hospitalized children with ARIs in China.
  pubmed Wang J, Jing L, Duan Y, Guan X 等 2026 Aug 10 置信度 0.82
• Lipid droplets confer SA-dependent antiviral defense without growth penalty.
  The role of lipid droplets (LDs), typically regarded as storage sites for neutral lipid, in plant defense remains poorly understood. In our study with barley stripe mosaic virus (BSMV), a (+)ssRNA virus, we found that infection significantly increases LD abund…
  pubmed Zhou L, Wen Z, Zhong C, Zhang D 等 2026 Aug 18 置信度 0.82
• Early detection of pertussis related activity by wastewater surveillance of Bordetella pertussis- and Bordetella parapertussis-associated DNA concentrations in Osaka, Japan.
  Pertussis causes recurrent outbreaks worldwide. Clinical surveillance can be affected by healthcare-seeking behaviour, diagnostic practices, testing sensitivity, and reporting delays. This study evaluated the utility of wastewater surveillance (WWS) by quantif…
  pubmed Suzuki K, Motooka D, Sakon N, Tomono K 2026 Dec 置信度 0.82
• Lactic acid bacteria-derived biosurfactants: emerging strategies for biofilm control, virulence attenuation, and food safety.
  Biofilm-associated infections caused by multidrug-resistant bacteria and fungi impose a substantial global health burden, and conventional antibiotics are increasingly ineffective at eradicating them due to poor penetration of the extracellular polymeric subst…
  pubmed Tabassum N, Kim T, Khan F 2026 Aug 10 置信度 0.82
• Genomic insights into efflux-mediated biofilm persistence and multidrug resistance in Achromobacter xylosoxidans from cystic fibrosis.
  Achromobacter xylosoxidans is an emerging opportunistic pathogen related to cystic fibrosis (CF). Its clinical impact is variable among patients depending on strain-specific genomic diversity and interaction with co-infecting pathogens. Hence, genomic analysis…
  pubmed Kouidhi B, Rhim H, Bhouri M, Kadri Y 等 2026 Aug 10 置信度 0.82
• Decision Tree Prediction of Saline Infusion Test Outcomes in Suspected Primary Aldosteronism: A Multicenter CDM Study.
  Confirmatory aldosterone suppression testing is widely utilized following positive screening for primary aldosteronism (PA), yet its incremental diagnostic value remains debated. While the 2025 Endocrine Society guideline proposes a probability-based approach,…
  pubmed Kim KJ, Choi J, Baek N, Park MJ 等 2026 Aug 10 置信度 0.82
• Precision Medicine in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia: Toward Personalized Diagnosis and Therapy.
  β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, iron loading, and organ complications vary widely among individuals. This structured narrative review summarizes practical applications …
  pubmed Karen AA, Tluli O, Hashem IE, Barhoma AM 等 2026 Aug 10 置信度 0.82
• The sweet spot in protein design-Where deep learning meets first principles.
  This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agre…
  pubmed Cia G, Orlando G, Cianferoni D, van der Kant R 等 2026 Aug 10 置信度 0.82
• microRNA-mediated control of cell fate specification and patterning in Marchantia polymorpha.
  MicroRNAs (miRNAs) are small non-coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER-LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double-stranded precursors that give rise to mature miRNAs…
  pubmed Aguilar-Cruz A, Flores-Sandoval E, Xu Y, Yu Y 等 2026 Aug 9 置信度 0.82
• Brain Tissue-Derived Exosomal Proteomics Identifies Chemotaxis-Associated Protein Changes After Traumatic Brain Injury: An Exploratory Hippocampal Transcriptomic Comparison.
  Traumatic brain injury (TBI) involves both primary and secondary pathological processes, including hemorrhage, ischemia, edema, and neuroinflammation. Although tissue-derived exosomes have emerged as important mediators of intercellular communication within lo…
  pubmed Chen WC, Chen XL, Lin CY, Huang YZ 等 2026 Aug 10 置信度 0.82
• Acute AKT signaling increases glucose phosphorylation and contribution to glycogen in hepatocytes.
  Insulin's regulation of hepatic glucose production and glycogen is critical for postprandial glucose disposal. AKT, a serine-threonine kinase and insulin signaling intermediate, regulates liver glucose metabolism through transcriptional and posttranslational m…
  pubmed Stefkovich M, Lee WD, Coopersmith T, Baur JA 等 2026 Aug 21 置信度 0.82
• Whole genome sequencing in cerebral palsy: a UK paediatric pilot study.
  Prior international studies indicate that 9-36% of people with cerebral palsy (CP) have a monogenic condition. However, the utility of whole genome sequencing (WGS) as a diagnostic tool for United Kingdom (UK) National Health Service (NHS) patients has not bee…
  pubmed Ratnaike TE, Pierce HH, Coffey AJ, Dias JML 等 2026 Sep 置信度 0.82
• Hereditary Polyneuropathy Experience of a Tertiary Single-Center in Türkiye: Beyond the Tip of the Iceberg.
  Hereditary polyneuropathies (HPPs), including Charcot-Marie-Tooth disease (CMT), represent a genetically and clinically heterogeneous group of disorders. Overlapping phenotypes, genetics, and clinical heterogeneity, and more complex phenotypes mimicking CMT ca…
  pubmed Avcı Ş, Eraslan S, Yunisova G, Kaysin M 等 2026 Aug 4 置信度 0.82
• Pulmonary Arterial Hypertension-Targeted Therapy for Pulmonary Hypertension Associated With Left Heart Disease: Bayesian and Frequentist Meta-Analysis of Randomized Controlled Trials.
  Pulmonary hypertension associated with left heart disease (PH-LHD) is the most prevalent form of pulmonary hypertension. Despite the recent advances in medications for pulmonary artery hypertension (PAH), it remains unclear whether PAH-targeted therapy is effe…
  pubmed Kiyohara Y, Sakai T, Freeman LM, Katzianer D 等 2026 Aug 4 置信度 0.82
• A complete hlyCABD-like RTX operon marks a virulence-associated subset of trh-positive Vibrio parahaemolyticus from Hangzhou Bay, China.
  Vibrio parahaemolyticus remains a major cause of seafood-associated gastroenteritis, yet routine surveillance still relies largely on the canonical hemolysin markers thermostable direct hemolysin (tdh) and tdh-related hemolysin (trh). To determine whether this…
  pubmed Wang L, He Y, He Y, Su X 等 2026 Aug 3 置信度 0.82
• A pan-cancer analysis reveals the multifaceted role of PABPC1L in immune regulation and therapy response.
  Although Poly(A)-binding protein cytoplasmic 1 like (PABPC1L) has been studied in specific cancer types, its broader potential as a prognostic biomarker remains uninvestigated, and the systematic pan-cancer analysis is currently lacking. We performed an integr…
  pubmed Sun K, He P, Chen L, Mu B 等 2026 Aug 8 置信度 0.82
• The Vascular Genome as a Therapeutic Target: A Systematic Review of CRISPR-based Gene Editing In Vascular Disease.
  Despite advances in therapy, arterial, venous, and pulmonary vascular diseases remain leading causes of morbidity and mortality. Persistent endothelial dysfunction, inflammation, oxidative stress, and maladaptive vascular remodeling continue to drive disease p…
  pubmed Ahad A, Hullon D, Singh T, Dabiry SM 等 2026 置信度 0.82
• The PavPIF3/PavMYC2-PavMYB75L/PavCOP1 regulatory module integrates light and jasmonic acid signaling to regulate fruit coloration in blush sweet cherry.
  Light induces blush sweet cherry fruit coloration. We determined that the phytohormone jasmonic acid (JA) is important for fruit coloration under light conditions. However, the genes and molecular mechanisms underlying the integrated regulatory effects of ligh…
  pubmed Qi X, Wang M, Liu L, Dong Y 等 2026 Aug 置信度 0.82
• Microbial Production of Alternative Proteins for Food Applications: Advances, Industrial Challenges, and Regulatory Status.
  The escalating global population and the environmentally inefficient nature of livestock-based protein production are intensifying demand for sustainable and scalable protein alternatives. Microbial biosynthesis, employing engineered cell factories, represents…
  pubmed Lu Z, Chen Z, Yang D, Agustiar AA 等 2026 Sep 置信度 0.82
• Expanded ATXN10 Alleles in Neurodegenerative Disorders: A Case Series and Review of the Literature.
  Spinocerebellar ataxia type 10 (SCA10 or ATX-ATXN10) is typically attributed to large intronic ATTCT repeat expansions in ATXN10, yet interpretation is complicated by repeat interruptions, reduced penetrance, and assay limitations.
  pubmed Cornejo-Olivas M, Raney A, Abad A, Sedov K 等 2026 Aug 8 置信度 0.82
• Robust Distance Correlation for Variable Screening.
  In modern statistical applications, identifying critical features in high-dimensional data is essential for scientific discoveries. Traditional best subset selection methods face computational challenges, while regularization approaches such as Lasso, SCAD and…
  pubmed Ma T, Yang F, Ke H, Ren Z 2025 Sep 置信度 0.82
• Multigene panel analysis of connective tissue and vascular genes in patients with a bleeding disorder of unknown cause or a cerebrovascular event.
  Bleeding disorder of unknown cause (BDUC) refers to patients with a significant bleeding phenotype despite normal hemostatic evaluation. Cerebrovascular events (CVEs) are neurologic deficits from intracerebral hemorrhages to hemorrhagic or ischemic strokes. A …
  pubmed Florquin M, Van Laer C, Kint C, Van Geet C 等 2026 Jul 置信度 0.82
• Insights into Phylum Asgardarchaeota: Analysis of Two Novel MAGs Within Class Njordarchaeia.
  The exploration of early evolutionary processes, particularly focusing on archaea, provides valuable insights into the beginnings of life on Earth. Archaea, one of the three domains of life, have significantly shaped our understanding of evolution. Within arch…
  pubmed Prajapati P, Giridharan B, Mootapally C, Nathani N 2026 Aug 置信度 0.82
• Deciphering Complex Carbohydrate Degrading Potential of Local Hot Spring Isolate Brevibacillus agri MX26 from Tuwa, Gujarat: Purification, Characterization and Genome Annotation.
  Hot springs are a treasure of valuable biological substances due to unique microbial diversity. Brevibacillus agri MX26, a thermophilic bacterium, was isolated from the Tuwa hot spring (63-64 °C, pH 8.2-9.0) and showed a multiple complex carbohydrate…
  pubmed Bharwad K, Shekh S, Patel A, Murty DS 等 2026 Aug 置信度 0.82
• Genomic characterization of carbapenem-resistant Acinetobacter baumannii from a specialized orthopaedic hospital in Southeast China, with phenotypic analysis of biofilm formation.
  Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major threat to hospitalised patients, particularly in intensive care units and orthopaedic wards where implant-associated infections are common. However, the genomic and biofilm characteristics of CRAB …
  pubmed Shi T, Xu S, Zheng X, Shi W 等 2026 置信度 0.82
• Occult squamous cell carcinoma presenting as oligometastatic lymphadenopathy. A systematic review with a case report.
  An occult squamous cell carcinoma (SCC) is a rare subtype of SCC for which standard radiological protocols are often unable to identify the primary tumour. We describe our patient's history and provide a systematic review of the literature.
  pubmed Ważny Ł, Ciesielka J, Jakimów K, Tobiasz A 等 2026 置信度 0.82
• Prevalence and genetic diversity of respiratory syncytial viruses circulating in Bulgaria, 2023-2025.
  Respiratory syncytial virus (RSV) is a major cause of acute respiratory infections (ARIs) with a considerable disease burden among children under 5 years of age. This study aimed to characterize the prevalence of RSV, genetic diversity of circulating strains, …
  pubmed Korsun N, Trifonova I, Uzunova Y, Velikov P 等 2026 置信度 0.82
• Prenatal screening and diagnostic strategies for fetal genetic abnormalities: Comparison of international clinical guidelines.
  This study compares recommendations from international clinical guidelines regarding prenatal screening and diagnostic testing for fetal genetic abnormalities, including the role of non-invasive prenatal testing (NIPT), invasive diagnostic procedures, and adva…
  pubmed Veras GS, Bennini JR 2026 Aug 8 置信度 0.82
• Comparative genomics of fatal ST308/O11 Pseudomonas aeruginosa from Egypt characterizes conserved resistance architecture, integron-associated multidrug resistance modules, and blaNDM-1 resistance islands.
  Pseudomonas aeruginosa is a major cause of ventilator-associated pneumonia (VAP) and is increasingly associated with extensive antimicrobial resistance, limiting therapeutic options and contributing to poor clinical outcomes. The emergence of high-risk clones …
  pubmed Sanad AA, El-Sherbeny GA, El-Morsi AA, Gad AF 等 2026 Aug 8 置信度 0.82
• Homologous recombination deficiency (HRD) testing of high-grade serous carcinoma using cytological samples.
  Homologous recombination deficiency (HRD) is associated with increased sensitivity to PARP inhibitor therapy in various cancer types, including high-grade serous carcinoma (HGSC). Current guidelines recommend HRD testing to guide treatment decisions in HGSG. T…
  pubmed Demmer I, Schmid MB, Born D, Handschin G 等 2026 Aug 7 置信度 0.82
• Decoding Calcium Signaling: Functional Roles of Calmodulin and Calmodulin‑Like Proteins in Plant Development and Stress Responses.
  Calcium (Ca 2+ ) acts as a ubiquitous secondary messenger in plants, orchestrating adaptive responses to developmental cues and environmental fluctuations. The decoding of these signatures is primarily mediated by calmodulin (CaM) and plant-specific calmodulin…
  pubmed Jin R, Zhang T, Bai X, You X 等 2026 Aug 7 置信度 0.82
• Artificial Intelligence-Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation.
  Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation. Convergence of mu…
  pubmed Lavecchia A 2026 Aug 7 置信度 0.82
• Genomic landscape and therapeutic implications of Anaplastic Lymphoma Kinase fusion-positive colorectal cancer.
  Anaplastic lymphoma kinase (ALK) fusions are established oncogenic drivers and therapeutic targets in multiple malignancies, including non-small cell lung cancer, but are rare in colorectal cancer (CRC). Although ALK fusions in CRC have been associated with se…
  pubmed Li X, Yasin F, Pavlick DC, Ross JS 等 2026 Aug 6 置信度 0.82
• Genotype-directed Targeted Therapy for Pediatric Vascular Malformations: A Systematic Review.
  Pediatric vascular malformations are rare, heterogeneous disorders increasingly driven by somatic mutations affecting key molecular pathways, particularly the PI3K-AKT-mTOR and RAS-MAPK signaling cascades. Advances in genomic profiling have enabled the use of …
  pubmed Kumar B, Patil N, Goel P, Jain V 等 2026 Jul-Aug 置信度 0.82
• Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.
  Age at menarche (AAM) is influenced by genetic and environmental factors and is associated with reproductive health outcomes. Therefore, understanding its genetic basis may help predict risks to women's health. This study aimed to identify genetic variants ass…
  pubmed Shin H, Jeon HK, Yoo HY 2025 Nov 置信度 0.82
• Advantages of Exome Sequencing Over Panel Testing for Individuals With a Seizure Indication.
  Our aim was to investigate the advantages of exome sequencing versus panel testing for patients with unexplained seizures.
  pubmed Morrow MM, Butler E, Napier MP, Havens-Dyer L 等 2026 Mar 置信度 0.82
• Putative glioblastoma origin-like cells in the subventricular zone: isolation and characterization.
  Glioblastoma (GBM) remains lethal despite maximal therapy. The adult subventricular zone (SVZ), a neural stem-cell niche, has been implicated as a potential site of origin, yet the identity and functional properties of putative GBM origin-like cells (GBM-OCs) …
  pubmed Oh HC, Choi RJ, Jo SY, Yeo E 等 2026 Aug 6 置信度 0.82
• Microbial composition, dynamics, and functional roles in jinhua ham fermentation: integrating starter cultures and multi-omics for quality and safety.
  Jinhua ham, a traditional Chinese dry-cured meat product with nearly a millennium of production history, derives its characteristic colour, layered aroma, and umami-rich taste from the coordinated biochemical activity of a dynamic microbial ecosystem across an…
  pubmed Sehar H, Chen Z, Zhang J, Wu K 等 2026 Oct 1 置信度 0.82
• Probe-based metagenomic sentinel surveillance of viral respiratory infections in primary care: a prospective, national, pilot study.
  With the introduction of metagenomics in clinical diagnostics unfolding and the expanding role of pathogen genomics in national surveillance, conditions are favourable for the further maturation of these approaches in public health surveillance. In this study,…
  pubmed Mourik K, Sidorov I, Meijers E, van den Brink S 等 2026 Aug 6 置信度 0.82
• Pharmacist-Led Management of Elizabethkingia Keratitis: Precision Therapy Guided by Culture and mNGS to Improve Clinical Outcomes and Efficiency.
  This study evaluated the clinical efficacy of a pharmacist-led antimicrobial stewardship program augmented by metagenomic next-generation sequencing (mNGS) for managing rare, multidrug-resistant Elizabethkingia keratitis.
  pubmed Du P, Zhou M, Wang L, Zhang X 2026 Jul 28 置信度 0.82
• Genetic dissection of a key dynamic growth period QTL for source-sink-related traits and its breeding application potential in wheat.
  Sustaining wheat yield gains requires optimizing the spatiotemporal coordination of source (leaves), transport (stems), and sink (spikes) organs. However, the physiological mechanisms and underlying genetic networks orchestrating the dynamic development of the…
  pubmed Yuan M, Ding H, Yue Y, Zhang C 等 2026 Aug 6 置信度 0.82
• Characterization of Pathogenic Photobacterium damselae subsp. damselae From Whiteleg Shrimp (Litopenaeus vannamei): An Emerging Cause of Mass Mortality in the Republic of Korea.
  Mass mortality events characterized by muscle whitening occurred in farmed whiteleg shrimp (Litopenaeus vannamei) in the Republic of Korea from July to September 2025. After ruling out the major crustacean pathogens listed by the World Organization for Animal …
  pubmed Park JH, Giri SS, Hwang MH, Park DS 等 2026 置信度 0.82
• AI-Driven Multiomics Biomarkers for Precision Oncology: Navigating the Translational Gap and Regulatory Hurdles.
  The discussion on precision oncology integrates multiomics technologies and artificial intelligence, specifically addressing biomarker discovery and personalized therapeutic strategies. In this way, clinical translation and multiomics biomarkers are reconstruc…
  pubmed Havelikar U, Shinde A, Mhaismale H, Pawar P 等 2026 Aug 6 置信度 0.82
• Near-complete genomes from six human coronavirus HKU1-positive samples recovered by metagenomics in coastal Kenya, 2024-2025.
  Human coronavirus HKU1 is globally endemic but genomically understudied. We present six near-complete HKU1 genomes from samples collected in coastal Kenya (2024-2025) that fell into genotypes A ( n = 3) and B ( n = 3). The data expand the global HKU1 genomic d…
  pubmed Lambisia AW, Nyawa OK, Maina G, Katama EN 等 2026 Aug 6 置信度 0.82
• Clinical characteristics and outcomes of patients with bacteraemia caused by non-carbapenemase-producing, carbapenem-resistant Enterobacterales.
  Carbapenem-resistant Enterobacterales (CRE) are classified as carbapenemase- and non-carbapenemase-producing (non-CP) CRE. The purpose of this study was to identify factors associated with meropenem non-susceptible non-CP CRE to help stratify treatment approac…
  pubmed Shah S, Clarke LG, Kline EG, Marini RV 等 2026 Aug 4 置信度 0.82
• Real-World Outcomes of Olaparib Treatment in Japanese Patients With Metastatic Castration-Resistant Prostate Cancer Harboring BRCA Pathogenic or Likely Pathogenic Variants.
  Olaparib has demonstrated clinical benefit in patients with metastatic castration-resistant prostate cancer (mCRPC) harboring BRCA pathogenic or likely pathogenic variants (PVs) in randomized clinical trials; however, multicenter real-world data in Japanese pa…
  pubmed Yasuda Y, Yoshida S, Yonese I, Sano Y 等 2026 Aug 置信度 0.82
• Potassium citrate for stone prevention - Quantifying benefit through the number needed to treat: A narrative review.
  To define how reliable the benefits of potassium citrate (KCit) for stone prevention are framing this in terms of the number needed to treat (NNT). A targeted search of PubMed/MEDLINE, Embase, and the Cochrane Library was conducted through January 2025. For st…
  pubmed Talyshinskii A, Pischetola A, Kamal W, Somani BK 2026 Jul-Sep 置信度 0.82
• Testing for Causal Association Between Serum Urate, Gout, and Prostatic Cancer in European Males.
  We conducted a two-sample Mendelian randomization (MR) study including only European men to test for a causal relationship between serum urate (SU), gout, and prostate cancer. Using genome-wide association (GWAS) data, we generated instrumental variables (IVs)…
  pubmed Chandrupatla S, Sumpter N, Takei R, Merriman TR 等 2025 Dec 置信度 0.82
• Twenty-Year Progress in Landscape Genetics of Tetrapods.
  Landscape genetics, an interdisciplinary field integrating population genetics, landscape ecology, and spatial analytical techniques, has progressed significantly over two decades, yet systematic reviews of its application to tetrapods remain limited. Here, we…
  pubmed Gu T, Jia X, He Y, Lin Z 2026 Aug 置信度 0.82
• Isolation and identification of a potential new bovine viral diarrhea virus genotype associated with severe outbreaks in yaks (Bos grunniens) in China.
  Bovine viral diarrhea virus (BVDV) is a globally significant pestivirus currently classified into three species: BVDV-1 (Pestivirus A), BVDV-2 (Pestivirus B), and BVDV-3 (HoBi-like, Pestivirus H). Here, we report the isolation and identification of a potential…
  pubmed Ye X, Zhang C, Wang Y, Zhang F 等 2026 置信度 0.82
• Uncovering the Hidden Diversity and Antimicrobial Resistance of Uropathogens in a Tertiary-Care Hospital in Bangladesh.
  Urinary tract infections (UTIs) are among the most common bacterial infections worldwide; however, their diagnosis in low- and middle-income countries often relies on conventional culture and biochemical methods with limited sensitivity. This study evaluated t…
  pubmed Hosen MA, Rahman T, Rahatuzzaman, Kabir RB 等 2026 置信度 0.82
• Primary Tumor Genomics and Patterns of Distant Recurrence in Resected Gastric Cancer.
  Patients with gastric cancer face substantial risk of recurrence after surgical resection. Molecular profiling of primary tumors may improve risk stratification to guide postoperative management.
  pubmed Coffey MR, Xu J, Atri P, Lambert KE 等 2026 Aug 5 置信度 0.82
• Elucidating the Nexus of Mitochondrial Dysfunction and Oncometabolite Accumulation in Tumorigenesis.
  Cancer is a complex disease driven by disruptions in cellular metabolism and mitochondrial function, enabling malignant cells to proliferate unchecked, evade apoptosis, and metastasize to distant organs. This exhaustive review elucidates the metabolic dysregul…
  pubmed Ubhenin AE, Idris RI, Adamude FA, Ochalefu DO 2026 Mar-Apr 置信度 0.82
• Impact of cryopreservation on PBMC-derived CAR-T cell manufacturing outcomes: a systematic review.
  Chimeric antigen receptor T-cell (CAR-T) therapy is an established treatment for several hematological malignancies, with peripheral blood mononuclear cells (PBMCs) serving as the starting material for manufacturing. Cryopreservation of PBMCs may offer logisti…
  pubmed Al-Wreidat RA, Alshwayyat S, Maharma LA, Al-Hussaini M 2026 置信度 0.82
• Oncogenic viruses and their role in oral cavity and oropharyngeal squamous cell carcinoma: a systematic review.
  Oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC) represent a major global health concern, accounting for most of head and neck malignancies. These tumors arise from the epithelial lining of the OC and oropharynx and are characterized by ag…
  pubmed Quiroga-Garza JM, Herrera-Saldivar MF, Hernandez-Bautista NC, Alanis-Valdez AY 等 2026 置信度 0.82
• Molecular insights into lower respiratory tract microbiota reveal disease-specific biomarkers and shared microbial networks in asthma and COPD.
  Lower respiratory tract infections (LRTIs) exacerbate chronic airway diseases, yet phenotype-specific microbial signatures are poorly defined. We applied broncho-alveolar lavage fluid (BALF) genomic sequencing to identify biomarkers for asthma and chronic obst…
  pubmed Huang Y, Zhao Y, Xin X, Lin S 2026 置信度 0.82
• Beyond detection: quantitative interpretation of Aspergillus-positive bronchoalveolar lavage fluid metagenomic next-generation sequencing for diagnostic stratification and prediction of respiratory deterioration.
  The increasing use of bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) has substantially improved the detection of Aspergillus species in patients with suspected pulmonary infections. However, positive mNGS results frequently p…
  pubmed Wang Y, Lei J, Cui S, Zhou P 等 2026 置信度 0.82
• Vitamin D receptor rs2228570 (FokI) variant is associated with chronic tinnitus susceptibility.
  Tinnitus is a multifactorial condition with complex and not fully elucidated pathophysiology. Emerging evidence suggests that vitamin D deficiency and neuroinflammatory mechanisms may contribute to tinnitus development. Although vitamin D receptor (VDR) gene p…
  pubmed Akalin H, Gokce N, Akyuz S, Boyacioglu O 等 2026 Aug 4 置信度 0.82
• Clinical, Biochemical, and Molecular Spectrum of Pseudohypoaldosteronism Type 1B in Indian Children: A Multicentric Case Series.
  Pseudohypoaldosteronism type 1 (PHA1) is a rare hereditary disorder characterised by aldosterone resistance leading to salt wasting, hyperkalaemia, and metabolic acidosis. Two forms are recognised: a milder renal form (PHA1A) due to NR3C2 mutations and a sever…
  pubmed Dhananjaya MS, Jakkadi L, Lalitha P, Rao LP 等 2026 Aug 4 置信度 0.82
• Putatively Adaptive and Genome-Wide Genetic Variation Often Rank Populations as Similarly Distinctive.
  Identifying which populations within species to prioritize to maintain genetic diversity is challenging. Due to its direct connection to current patterns of adaptation and presumed connection to adaptive capacity, some researchers advocate prioritizing adaptiv…
  pubmed Chhina AK, Fernandez-Fournier P, Lewthwaite JMM, Booker TR 等 2026 Aug 置信度 0.82
• Tolerability and Safety of Nintedanib and Immunosuppression in Autoimmune Inflammatory Myopathy-Associated Progressive Pulmonary Fibrosis.
  Autoimmune-inflammatory myopathy-related interstitial lung diseases (AIM-ILDs) are often progressive and fibrotic. Given their rarity, little is known about the safety and tolerability of antifibrotic nintedanib in combination with immunosuppression in AIM-ILD…
  pubmed Assayag D, Brilland B, Hudson M, Azuelos I 等 2026 Mar 置信度 0.82
• Nosological reappraisal of primary cutaneous apocrine carcinoma based on a clinicopathological and genetic analysis of 30 cases.
  The nosology of primary cutaneous apocrine carcinoma remains controversial, as the term has often been used as a heterogeneous diagnostic category. The aim of this study was to clarify the clinicopathological and molecular features of strictly defined apocrine…
  pubmed Goto K, Kukita Y, Ohe S, Hishima T 等 2026 Aug 3 置信度 0.82
• Artificial intelligence-based diagnostic model for identifying PTPRZ1-MET fusion in a clinically defined secondary glioblastoma cohort.
  Glioblastoma (GBM) is an aggressive and highly lethal brain tumor. Secondary glioblastoma (sGBM), which arises through malignant progression from lower-grade diffuse glioma, represents a clinically and biologically distinct subset of GBM. In this disease conte…
  pubmed Zhang JH, Shi J, Zhou HX, Tan WL 等 2026 Aug 4 置信度 0.82
• Surgical Versus Medical Management in Older Adults with Traumatic Brain Injury: A Systematic Review and Meta-analysis.
  Traumatic brain injury (TBI) in older adults is associated with high mortality and poor functional outcomes. However, optimal management remains uncertain, as evidence comparing surgical and medical strategies is limited, heterogeneous, and extrapolated from y…
  pubmed Cueva-Cañola LE, Beltrán-De la Fuente AC, Ayala-Alban MS, Morales Acosta S 等 2026 Aug 3 置信度 0.82
• Skin Lipid Dysregulation in Atopic Dermatitis and Related Inflammatory Skin Diseases.
  Epidermal lipids are essential for skin barrier function and actively influence cutaneous immune homeostasis. Recent advances have transformed our understanding of skin lipid dysregulation in allergic diseases, revealing complex bidirectional relationships bet…
  pubmed Kim HB, Park J, Lim CS, Um JY 等 2026 Jul 置信度 0.82
• About the editor
  crossref 2024-11-29T15:58:27Z 置信度 0.70
• Genomics for Nurses
  crossref Jodie Coulson 2025-09-04T16:17:48Z 置信度 0.70
• About the editors
  crossref 2025-01-31T19:22:17Z 置信度 0.70
• Copyright
  crossref 2025-03-14T21:34:44Z 置信度 0.70
• Regulatory guidance on therapeutic proteomics and genomics
  crossref Shikha Patel, Yesha Patel, Meet Adodariya, Aliasgar Shahiwala 等 2025-03-14T21:32:53Z 置信度 0.70
• Profiling conserved transcription factor binding motifs in Phaseolus vulgaris through comparative genomics
  Abstract Common bean ( Phaseolus vulgaris ), a staple food in Latin America and Africa, serves as a vital source of energy, protein, and essential minerals for millions of people. However, genomics knowledge that breeders could leverage for improvement of this…
  crossref Liudmyla Kondratova, C. Eduardo Vallejos, Ana Conesa 2025-02-20T12:00:17Z 置信度 0.70
• Doubling the grain: Harnessing the power of DG1 promoter inversion in sorghum
  crossref Tilak Chandra 2025-06-11T23:57:49Z 置信度 0.70
• Morphogenesis modulation of Rhizopus oryzae by peptone enhances lipase production during submerged fermentation
  crossref Ayda Torchi 2025-09-05T18:23:49Z 置信度 0.70
• Interview with Dr. Lutz Roewer, Pioneer of Y-STR DNA Analysis
  crossref Nicole Novroski 2025-06-12T16:36:14Z 置信度 0.70
• Using Genomics to Inform the Management of Biological Invasions: from Sequencing Genomes to Sequencing Biomes
  crossref Dan G. Bock, Marc Rius 2025-12-17T11:53:33Z 置信度 0.70
• Genomics-Assisted Breeding in Peanut
  crossref Chuanzhi Zhao, Xingjun Wang 2025-11-05T19:01:13Z 置信度 0.70
• The Genomics of Aging at the Single-Cell Scale
  Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellula…
  crossref Wei Zhou, Junyue Cao 2025-04-25T16:41:25Z 置信度 0.70
• The Ecological Genomics of Algae
  crossref Senjie Lin 2025-06-23T09:29:30Z 置信度 0.70
• Challenges of reproducible AI in biomedical data science
  Abstract Artificial intelligence (AI) is revolutionizing biomedical data science at an unprecedented pace, transforming various aspects of the field with remarkable speed and depth. However, a critical issue remains unclear: how reproducible are the AI models …
  crossref Henry Han 2025-01-10T09:17:26Z 置信度 0.70
• A new Galaxy workflow to generate and evaluate reference genome assemblies
  crossref 2025-05-27T13:55:22Z 置信度 0.70
• Correction: Mapping-based genome size Estimation
  crossref Shakunthala Natarajan, Jessica Gehrke, Boas Pucker 2025-07-14T05:36:34Z 置信度 0.70
• Research Progress on Traits Improvement of Cotton Plants Based on Comparative Genomics
  crossref Zhen Li 2025-08-01T03:46:52Z 置信度 0.70
• Iterative improvement of deep learning models using synthetic regulatory genomics
  Abstract Deep learning models can accurately reconstruct genome-wide epigenetic tracks from the reference genome sequence alone. But it is unclear what predictive power they have on sequence diverging from the reference, such as disease- and trait-associated v…
  crossref André M. Ribeiro-dos-Santos, Matthew T. Maurano 2025-02-07T04:35:13Z 置信度 0.70
• Phylogenetic Position of Durian and Comparative Genomics with Close Relatives in Malvaceae
  crossref Haimei Wang 2025-11-21T03:22:31Z 置信度 0.70
• Advancing our understanding of poplar growth using a multi-omics approach
  crossref Wirulda Pootakham 2025-05-08T04:03:57Z 置信度 0.70
• Preface
  crossref Dhavendra Kumar, Ruth Chadwick 2024-11-15T04:21:38Z 置信度 0.70
• Study on the anticancer function and mechanism of cathelicidin-DM in liver cancer
  crossref Huang Hu, Jingjing Tai, Ruiyun Zhang, Hong Zhang 2025-04-25T11:52:20Z 置信度 0.70
• Genomics for clinical outcome prediction in chronic respiratory diseases (CRDs).
  crossref Margherita Carnevale Schianca, Gianmarco Putti, Leonardo Terranova, Marco Mantero 等 2025-11-25T15:34:31Z 置信度 0.70
• Correction to: Genomics Based Approaches for Tropical Tree Improvement and Conservation
  crossref Ani A. Elias, Yasodha Ramasamy 2025-07-29T12:56:10Z 置信度 0.70
• Introduction to deep learning for genomics
  crossref Afroj Alam, Naiwrita Borah, Haseeb Khan, K.O. Mohammed Aarif 等 2024-11-29T15:59:49Z 置信度 0.70
• Index
  crossref 2025-02-28T15:32:12Z 置信度 0.70
• Single-cell proteomics using mass spectrometry
  crossref Amanda Momenzadeh, Jesse G. Meyer 2025-08-21T04:07:18Z 置信度 0.70
• Index
  crossref 2025-03-14T21:34:41Z 置信度 0.70
• Programming Basics: Data Types, Functions, and Loops
  This chapter introduces foundational Python programming concepts essential for bioinformatics and genomics, highlighting the value of learning to code even when existing tools are available. It presents core data types—numbers, strings, and lists—and explains …
  crossref Jamil Momand, Eliot Bush 2026-03-27T12:57:02Z 置信度 0.70
• Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos
  Abstract Understanding gene function in vertebrate development requires tools that allow precise and timely manipulation of gene expression. Zebrafish ( Danio rerio ), with its transparent embryos and rapid development, offers an ideal model to study vertebrat…
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• CRIF counteracts oncogenic Ras and regulates heterochromatin
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