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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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Accurate prediction of DNA-protein interactions, a fundamental task in genomics, is limited by the poor generalization of existing models to novel proteins not seen during training. To address this challenge, we introduce Qimai, a modular AI agent framework th…
preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2026
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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preprints
2025
置信度 0.74
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crossref
Jodie Coulson
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This chapter introduces substitution matrices by explaining matrix notation and showing how bioinformaticians use evolutionary models to score amino acid similarities. It presents the development of point accepted mutation (PAM) matrices based on accepted amin…
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Jodie Coulson
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This chapter traces the development of genomics, beginning with classical genetics, which establishes the fundamental principles of heredity through the work of Darwin, Mendel, Morgan, and Sturtevant. It examines how genetic and physical maps reveal genome org…
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Arthur M. Lesk
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This chapter presents experimental and computational approaches to determining protein structures, focusing on secondary and tertiary levels. It describes how researchers use X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to reveal molec…
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This chapter explores the structure and function of chromosomes in relation to human health and disease, focusing on their role in genetic inheritance and precision medicine. It explains how chromosomes are organised within the cell nucleus, how they change dy…
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This chapter examines the genomes of prokaryotes and viruses, highlighting their evolution, diversity, and ecological significance. It explores the phylogenetic relationships among bacteria, archaea, and eukaryotes, emphasising genetic exchange, metabolic adap…
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This chapter introduces foundational algorithms that enable pairwise alignment of protein sequences using substitution matrices. It explains the sliding window approach, which facilitates the visualisation of sequence properties, such as GC-rich regions or hyd…
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ABSTRACT Long interspersed element-1 (LINE-1, L1) retrotransposons are the most abundant protein-coding transposable elements (TE) in mammalian genomes, and have shaped genome content over 170 million years of evolution. LINE-1 is self-propagating and mobilize…
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Molecular profiling of DNA and RNA from pediatric cancers by next-generation sequencing has been demonstrated to improve diagnosis and prognosis and to identify somatic alterations indicating vulnerability to targeted therapies. Hence, much like in the treatme…
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This chapter introduces advanced probabilistic models essential for evaluating sequence alignments in bioinformatics. It begins by explaining how extreme value distribution quantify the significance of sequence similarities, focusing on the interpretation of P…
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This chapter introduces essential molecular biology concepts critical to understanding bioinformatics, focusing on the flow of genetic information from DNA to RNA and proteins. It explains how genes, composed of nucleotide sequences, transcribe into RNA, which…
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The sequence of the 16S region is taxonomically informative and widely used for genotyping microbes. While it is easy and inexpensive to genotype several isolates by Sanger sequencing the 16S region, this method becomes quite costly if scaled to many isolates.…
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Abstract As genomic research scales globally, legal constraints such as data localization provisions in data privacy and other laws and ethical imperatives around privacy and sovereignty increasingly challenge traditional models of data sharing. Data visiting,…
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Abstract microRNAs (miRNAs) are central post-transcriptional regulators that shape cellular functions, development, and phenotypic diversity. Yet their evolutionary history in mammals remains poorly resolved, largely due to incomplete genome-wide annotation an…
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