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• Distinct Gut Microbiomic and Metabolomic Signatures in Knee and Hip Osteoarthritis.
  europepmc 2026 置信度 0.80
• Genome wide characterization and expression profiling of protein disulfide isomerase (PDI) gene family members in watermelon under cold stress.
  europepmc 2026 置信度 0.80
• Comparative Genomics
  This chapter examines the unity and diversity of life by analysing genomes, which define species, reveal evolutionary relationships, and demonstrate the role of horizontal gene transfer in reshaping the ‘tree of life’. It explains how genomes differ in size, o…
  crossref Arthur M. Lesk 2025-10-10T07:06:04Z 置信度 0.70
• Genomics
  This chapter traces the development of genomics from early viral and bacterial sequencing to the complex structure of the human genome. It begins by outlining key breakthroughs in DNA sequencing, including Sanger's dideoxy method and the rise of next-generatio…
  crossref Jamil Momand, Eliot Bush 2026-03-27T12:57:06Z 置信度 0.70
• Editorial Board
  crossref 2025-02-22T13:26:20Z 置信度 0.70
• Introduction to Genomics
  Introduction to Genomics blends together theory and practice to provide an overview of the subject of medical genetics and genomics, from basic to in-depth principles. It provides an overview of the similarities and differences between organisms and shows how …
  crossref Arthur M. Lesk 2025-10-10T07:06:03Z 置信度 0.70
• Editorial Board
  crossref 2025-05-16T15:11:52Z 置信度 0.70
• Editorial Board
  crossref 2025-01-22T20:37:42Z 置信度 0.70
• Editorial Board
  crossref 2025-08-13T19:15:46Z 置信度 0.70
• Editorial Board
  crossref 2025-12-02T20:31:54Z 置信度 0.70
• Aging, genomics, and society
  crossref Joona Räsänen 2024-11-15T04:20:25Z 置信度 0.70
• Medical Genetics and Genomics
  Medical Genetics and Genomics contains chapters that look into how genes influence disease and individual responses to treatment. It also shows how genetic knowledge can be applied for disease prediction, diagnosis, and prognosis and explains why understanding…
  crossref Emanuela Volpi, Lorna Tinworth 2025-12-10T16:31:56Z 置信度 0.70
• Bioinformatics
  This chapter examines databases in molecular biology, detailing their organisation, integration, and role in bioinformatics. It explains how data flow through bioinformatics, from deposition and curation to retrieval and computational analysis, emphasising the…
  crossref Arthur M. Lesk 2025-10-10T07:06:02Z 置信度 0.70
• Proteomics
  This chapter examines proteins, which are essential macromolecules that drive cellular functions, including enzymatic catalysis, transport, regulation, and structural support. It explores protein structure from primary amino acid sequences to complex three-dim…
  crossref Arthur M. Lesk 2025-10-10T07:06:07Z 置信度 0.70
• Metabolomics
  This chapter explores metabolomics by examining metabolic networks, classifying and assigning protein functions, and organising metabolic information in databases. It describes the Enzyme Commission's hierarchical classification system and the Gene Ontology Co…
  crossref Arthur M. Lesk 2025-10-10T07:06:09Z 置信度 0.70
• Transcriptomics
  This chapter examines transcriptomics, focusing on its applications in analysing gene expression across species, physiological states, and diseases. Microarrays detect ribonucleic acid (RNA) sequences through hybridisation but yield semiquantitative data, whil…
  crossref Arthur M. Lesk 2025-10-10T07:06:07Z 置信度 0.70
• Concepts in Bioinformatics and Genomics
  Concepts in Bioinformatics and Genomic takes a conceptual approach, balancing biology, mathematics, and programming while highlighting real-world applications. It provides tools to compute and analyse biological data. The book starts with a review of molecular…
  crossref Jamil Momand, Eliot Bush 2026-03-27T12:57:05Z 置信度 0.70
• Genomics
  crossref 2026-01-07T05:58:26Z 置信度 0.70
• Systems Biology
  This chapter explores systems biology as an integrative framework that analyses biological processes through network-based approaches. It examines regulatory mechanisms that govern cellular activities and highlights the parallel operation of physical networks …
  crossref Arthur M. Lesk 2025-10-10T07:06:13Z 置信度 0.70
• Foreword —“Genomics; the big picture” by Professor Sir John Burn
  crossref 2024-11-15T04:21:24Z 置信度 0.70
• The environment, population health ethics, and genomics
  crossref Benjamin Capps 2024-11-15T04:20:47Z 置信度 0.70
• Genomics and digital health
  crossref Vajira H.W. Dissanayake, Dulika Sumathipala 2024-11-15T04:21:01Z 置信度 0.70
• Population Genomics: Insects
  crossref 2025-11-19T06:59:35Z 置信度 0.70
• Genomics and Anthropology: Human Evolution, Migration, and Domestication of Plants and Animals
  This chapter explores the ancestry of Homo sapiens , detailing the evolutionary journey from early primates to modern humans, with genomic studies revealing their close connections to Neanderthals and Denisovans. It examines ancient human migrations, tracing t…
  crossref Arthur M. Lesk 2025-10-10T07:06:09Z 置信度 0.70
• Discrepancies in global genomics education
  crossref Maha Saber-Ayad 2025-06-02T07:12:33Z 置信度 0.70
• Introduction and Background
  This chapter establishes genomics as the central discipline in biology, detailing the structure, function, and organisation of genomes across diverse life forms. It explains how genomes encode genes, regulatory elements, and non-coding sequences, influencing p…
  crossref Arthur M. Lesk 2025-10-10T07:06:01Z 置信度 0.70
• Basic Probability
  This chapter introduces the fundamental concepts of probability essential for understanding statistical tools used in bioinformatics. It begins by reviewing set theory and basic probability rules, including unions, intersections, and complements, and explains …
  crossref Silvia Heubach 2026-03-27T12:57:13Z 置信度 0.70
• Computational genomics and bioinformatics
  crossref Letizia Vestito, Valentina Cipriani, Damian Smedley 2024-11-15T04:20:05Z 置信度 0.70
• Phylogenetics
  This chapter explores the field of phylogenetics, which reconstructs evolutionary relationships using sequence data, fossils, and computational tools. It introduces the molecular clock hypothesis, which proposes that molecular sequences evolve at roughly const…
  crossref Jamil Momand, Eliot Bush 2026-03-27T12:57:14Z 置信度 0.70
• Genomes of Eukaryotes
  This chapter examines the origin and evolution of eukaryotes, establishing their descent from prokaryotic ancestors, highlighting key evolutionary milestones, including the emergence of multicellularity and specialised body plans. It explores the phylogenetic …
  crossref Arthur M. Lesk 2025-10-10T07:06:07Z 置信度 0.70
• Genomics, Populations, and Society
  crossref 2024-11-15T04:30:19Z 置信度 0.70
• “Health, Economic and Societal benefits of Genomics” by Professor Dame Sue Hill
  crossref 2024-11-15T04:21:29Z 置信度 0.70
• Editorial Board
  crossref 2025-09-29T14:21:27Z 置信度 0.70
• Basics of genetics and genomics
  crossref Sreeram Chandra Murthy Peela 2024-11-29T15:59:47Z 置信度 0.70
• The governance of international genomics' collaborations: Opportunities and challenges
  crossref Yann Joly 2024-11-15T04:20:48Z 置信度 0.70
• Editorial Board
  crossref 2025-11-21T18:32:24Z 置信度 0.70
• Editorial Board
  crossref 2025-12-30T17:43:31Z 置信度 0.70
• Data-driven genomics: A triad of big data, cloud, and IoT in genomics research
  crossref Alisha Ansari, Shalesh Gangwar, Khalid Raza 2024-11-29T15:59:33Z 置信度 0.70
• Erratum
  crossref 2025-12-10T09:15:49Z 置信度 0.70
• [Drug resistance of clinical Mycobacterium tuberculosis isolates and molecular characteristics of rifampicin-resistant isolates from elderly pulmonary tuberculosis patients in Beijing, 2024].
  Objective: To analyze the drug resistance spectrum of clinical isolates of Mycobacterium ( M. ) tuberculosis and the mutations in drug resistance-related genes in the genomic sequences of rifampicin-resistant isolates from elderly pulmonary tuberculosis (TB) p…
  pubmed Deng Y, Miao HH, Pang MD, Zhang J 等 2026 Aug 10 置信度 0.82
• Toward improved calf health in French dairy cattle breeds: Genetic parameters for calf survival across key periods.
  Shifts in the dairy cattle industry have placed greater emphasis on breeding healthier animals. While adult cow health-related traits have historically been more studied than calf health-related traits, largely due to greater data availability, the significant…
  pubmed Chapard L, Aguerre S, Vallée R, Besnard F 等 2026 Aug 19 置信度 0.82
• Centralized Digital Surveillance for Abdominal Aortic Aneurysm Detection, Longitudinal Tracking, and Management Within an Integrated Health System: Retrospective Cohort Study.
  Incidental detection of abdominal aortic aneurysms (AAAs) has increased with widespread cross-sectional imaging, while traditional surveillance remains fragmented and clinician-dependent. Real-world descriptions of centralized digital surveillance programs com…
  pubmed Ryer EJ, Salzler GG, Goldfarb M, Lewis AJ 等 2026 Aug 19 置信度 0.82
• Design, Synthesis, and Antifungal Activity of Novel Oxadiazole-Pyrazole-Triazole Derivatives: Insights into Cellular Disruption Revealed by Integrated Transcriptomic and Proteomic Analyses.
  Resistance to single-target fungicides necessitates structurally innovative antifungal agents with broadened modes of action. Herein, a series of pyrazole-oxadiazole-linked 1,2,4-triazole derivatives (L1-L39) were designed and synthesized via molecular hybridi…
  pubmed Wang FL, Ren XL, Gao L, Ruan R 等 2026 Aug 19 置信度 0.82
• Differential Expression of Human and Bacterial Proteins Reveals Microbiome-Host Crosstalk in Metabolic Disorders.
  The growing prevalence of obesity, MetS, and T2DM highlights the need to better understand host-microbiota interactions. While gut microbiota has been widely investigated, interactions between the oral microbiota and human salivary proteins remain largely unex…
  pubmed da Silva CVF, da Silva CJF, Marinho FDS, Sade YB 等 2026 Sep 置信度 0.82
• Analysis of HIV Drug Resistance Mutations Along With Treatment Outcomes of Efavirenz-Based Regimens in Patients With V179D/E Mutations in Guangzhou, China.
  To analyze the prevalence of human immunodeficiency virus type 1 (HIV-1) drug resistance mutations (DRMs) and compare the therapeutic outcomes of different antiretroviral treatment regimens in newly diagnosed HIV-1-infected patients with the V179D/E mutation.
  pubmed Zheng X, Xiao Y, Zhang Y, Wang P 等 2026 置信度 0.82
• Drug-resistant tuberculosis and pulmonary co-infections in immunocompromised patients: from multi-omics to precision therapy.
  Drug-resistant tuberculosis remains a major global health threat, with an estimated 400,000 people developing rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) worldwide in 2023, according to the WHO Global Tuberculosis Report 2024. Immunocompr…
  pubmed Wang A, Reheman H, Chen X, Shang M 等 2026 置信度 0.82
• Genomic Surveillance and Phylogenetic Analysis of Influenza A(H1N1) pdm09 and A(H3N2) Viruses in Burkina Faso, 2024.
  Influenza is a major cause of acute respiratory infections worldwide. In tropical regions such as Sub-Saharan Africa, influenza circulates year-round with irregular peaks, yet genomic data guiding prevention strategies remain limited. This study characterized …
  pubmed Sawadogo C, Cissé A, Gouba N, Ilboudo AK 等 2026 置信度 0.82
• Development of a highly efficient prime editing platform for cucurbits enables breeding of multi-disease-resistant cucumber.
  The prime editing (PE) system is a precise genome editing technology that works efficiently in monocots; however, its application is limited by low editing efficiency in dicots, particularly Cucurbitaceae and Solanaceae plants. Here, we first significantly imp…
  pubmed Wang J, Xiao L, Xin T, Li J 等 2026 Aug 19 置信度 0.82
• Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States.
  Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are active and dynamic regulators of central nervous system (CNS) development, homeostasis, and disease. Through extensive interactions wit…
  pubmed Baltar J, Abati R, Florido L, Holt MG 2026 Oct 置信度 0.82
• Hidden genomic structure and widespread structural polymorphism across environmental gradients in the spiny sea star Marthasterias glacialis.
  Genomic regions of reduced recombination can preserve linkage among co-adapted alleles, facilitating local adaptation despite high connectivity. Such regions-often generated by chromosomal inversions-may be especially important in highly dispersive marine taxa…
  pubmed Martín-Huete M, García-Berro A, Mérot C, Pérez-Portela R 等 2026 Aug 19 置信度 0.82
• Temporal Patterns in the Occurrence of Principal Salmonella Serotypes for Raw Meat and Poultry Products in the United States: 1998-2024.
  Microbial foodborne pathogens, such as Salmonella, have the characteristic that only some subgroups of these bacteria are highly pathogenic to humans. For the Salmonella species enterica, there are more than 2,600 serotypes. These serotypes can be host-adapted…
  pubmed Williams MS, Evans PS, Golden NJ 2026 Aug 18 置信度 0.82
• Global and regional progress towards reduced burden of oral conditions between 2019 and 2023: a systematic analysis for the Global Burden of Disease Study 2023.
  WHO's Global Oral Health Action Plan (GOHAP) targets include a 10% relative reduction in the combined prevalence of main oral conditions by 2030. The first GOHAP evaluation was planned for 2023, with subsequent evaluations scheduled for 2026 and 2030. The aim …
  pubmed GBD 2023 Oral Disorders Collaborators 2026 Sep 置信度 0.82
• Measuring the composition and availability of human resources for health by sex in 204 countries and territories, 1990-2023, and workforce gaps for universal health coverage: a systematic analysis for the Global Burden of Disease Study 2023.
  Understanding the size, gender composition, and cadre mix of the health workforce and how it has evolved across time and locations can inform policies for planning, recruitment, training, and retention of human resources for health (HRH), and improvement of ac…
  pubmed GBD 2023 Human Resources for Health Collaborators 2026 Sep 置信度 0.82
• Inhibition of RBM25 preserves cardiac mitochondrial homeostasis and attenuates ischemic heart failure.
  Heart failure (HF) after myocardial infarction (MI) is a serious complication that endangers the health of the patient. Mitochondrial dysfunction is an important mechanism in the development of ischemic HF. RNA-binding motif protein 25 (RBM25) is an RNA-bindin…
  pubmed Liu S, Ding H, Li K, Zhang X 2026 Aug 18 置信度 0.82
• Multidrug-resistant livestock-associated ST9-MRSA causing severe human infection without animal exposure: the food chain as a potential transmission route in China.
  ST9 methicillin-resistant Staphylococcus aureus (MRSA) is a typical livestock-associated lineage in Asia and represents an important reservoir of antimicrobial resistance (AMR). However, its contribution to human infection and its transmission pathways remain …
  pubmed Zhang W, Wu ZH, Xing GF, Hou X 等 2026 Aug 18 置信度 0.82
• Pathologic and multi-omic characterization of de novo neuroendocrine carcinoma of the prostate: A single center experience.
  De novo neuroendocrine carcinoma (NECa) of the prostate is a rare, aggressive malignancy distinct from therapy-related forms, that remains poorly characterized at the molecular level. Here we analyzed six cases, including pure and mixed forms with adenocarcino…
  pubmed Grypari IM, Logotheti S, Panopoulou E, Lazaros K 等 2026 Aug 18 置信度 0.82
• ROS-Responsive Eye Drop for Controlled Release of 20-Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming.
  Impaired corneal wound healing in diabetes remains a major clinical challenge, driven by defective autophagy, metabolic dysregulation, and sustained inflammation within a high-reactive oxygen species (ROS) microenvironment. Here, we engineered a ROS-responsive…
  pubmed Wu J, Chen W, Qiu H, Zheng W 等 2026 Aug 18 置信度 0.82
• Exclusion of patients with brain metastases from early-phase systemic therapy trials: a cross-sectional analysis of eligibility criteria.
  Patients with brain metastases (BrM) are frequently excluded from early-phase clinical trials, limiting evaluation of central nervous system (CNS) efficacy of novel therapies. We aimed to determine the proportion of phase I systemic therapy trials for patients…
  pubmed Zatzman C, Fernandes I, Kojundzic I, D'Souza N 等 2026 Aug 17 置信度 0.82
• Clinical and genomic characterization of brain metastasis in bladder cancer.
  Bladder cancer brain metastasis (BrM) remains a poorly characterized clinical entity in neuro-oncology. The current study combines clinicopathologic and genomic sequencing data to identify prognostic factors in bladder cancer BrM.
  pubmed Manoranjan B, Zeller S, Price H, Reiner AS 等 2026 Aug 18 置信度 0.82
• Corrigendum to "Chromosome-level genome sequencing and multi-omics of the Hungarian White Goose (Anser anser domesticus) reveals novel miRNA-mRNA regulation mechanism of waterfowl feather follicle development", [Poultry Science, Volume 103, Issue 9, September 2024, 103933].
  pubmed Zhou Y, Mabrouk I, Ma J, Liu Q 等 2026 Aug 17 置信度 0.82
• Multiple introductions of highly pathogenic avian influenza viruses into the High Arctic: Svalbard and Jan Mayen, 2022-2025.
  Between 2022 and 2025, highly pathogenic avian influenza viruses (HPAIVs) of clade 2.3.4.4b, including four distinct H5 Eurasian (EA) genotypes, were detected in wild birds and mammals in the Svalbard Archipelago and on the island of Jan Mayen. We describe the…
  pubmed Granstad S, Tønnessen R, Ytrehus B, Descamps S 等 2026 Aug 置信度 0.82
• Diagnostic Yield of Whole Exome Sequencing in Autism Spectrum Disorder Patients at a Tertiary Center in Saudi Arabia.
  Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous neurodevelopmental condition. Whole‑exome sequencing (WES) is a pivotal diagnostic tool, though its yield varies across populations. This study aimed to determine the diagnosti…
  pubmed Alasiri A, Al-Jabri B, Abukhaled M, Aldhalan H 等 2026 Aug 17 置信度 0.82
• The Diagnostic Performance of Afirma Genomic Sequencing Classifier in Black and Hispanic Patients With Indeterminate Thyroid Nodules.
  About 20% of thyroid nodules detected on ultrasound are cytologically indeterminate (Bethesda categories III and IV), but the rate of malignancy of these nodules is less than 36%. The ability of Afirma Genomic Sequencing Classifier (GSC) to further risk-strati…
  pubmed Attia PJ, Chinta S, Celidonio J, Armas JS 等 2026 Aug 17 置信度 0.82
• Prevalence and Molecular Characterization of Aminoglycoside Resistance Genes Among Drug-Resistant Pseudomonas aeruginosa Clinical Isolates in Chinese Hospital.
  Pseudomonas aeruginosa is a major cause of nosocomial infections, with increasing multidrug resistance complicating treatment outcomes. Aminoglycosides remain a cornerstone for managing P. aeruginosa infections, but resistance is escalating globally. This stud…
  pubmed Wang R, Xu Y 2026 Aug 17 置信度 0.82
• Prevalence, Clonal Context, and Clinical Correlates of Arr in Klebsiella Pneumoniae from a Specialized Infectious Disease Hospital.
  Rifampicin (RFP) is central to the management of tuberculosis (TB) and nontuberculous mycobacterial (NTM) infections, and specialized infectious disease hospitals therefore use it routinely. Whether rifamycin resistance determinants are enriched among co-resid…
  pubmed He L, Liu T, Xiang J, Yan M 等 2026 置信度 0.82
• Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients.
  Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14. For understanding disease evolution and imminent trial planning, metrics of the most widely used clinic…
  pubmed Traschütz A, Hilgers RD, Erdlenbruch F, Depienne C 等 2026 Aug 15 置信度 0.82
• Candidate genomic regions associated with differential clinical response to lumpy skin disease in sahiwal cattle.
  Lumpy Skin Disease (LSD) is a transboundary viral disease of cattle associated with substantial economic losses. During an LSD outbreak at ICAR-National Dairy Research Institute, Sahiwal cattle maintained at the institute and vaccinated with a live attenuated …
  pubmed Misal S, Patil A, Chhotaray S, Alex R 等 2026 Aug 15 置信度 0.82
• Cross-species genomic analysis of Salmonella enterica subspecies enterica serovar Dublin isolated from dairy cattle, dogs, and humans in Florida from 2019 to 2024.
  Salmonella enterica serovar Dublin ( S. Dublin) is a cattle-adapted pathogen that can cause severe systemic infections in humans and animals. Understanding genomic relatedness across host species is essential for assessing the zoonotic potential and disseminat…
  pubmed DeZoysa AR, Edison LK, Denagamage T, Pellissery AJ 等 2026 Dec 置信度 0.82
• Rationale and trial design of RIBOLARIS: A phase II trial of neoadjuvant and adjuvant ribociclib plus endocrine therapy for clinically high-risk HR+/HER2-negative breast cancer.
  Despite advances in endocrine therapy, patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC) remain at risk of recurrence (ROR). Chemotherapy is often used in high-risk cases, but not …
  pubmed Cottu P, Pascual T, Lemonnier J, Hu H 等 2026 置信度 0.82
• Comparative genomic insights into carbapenem-resistant versus susceptible Acinetobacter baumannii in Shanghai hospital settings: a multi-center molecular surveillance study.
  Carbapenem-resistant Acinetobacter baumannii (CRAB) is priority pathogen for nosocomial infection control worldwide. This study aimed to elucidate differences in distribution, genotyping and antimicrobial resistance patterns between CRAB and carbapenem-suscept…
  pubmed Zhang Y, Liang Y, Wang Y, Xu Y 等 2026 置信度 0.82
• Histological aging signatures for monitoring tissue-specific aging and disease.
  Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from …
  pubmed Abila E, Buljan I, Zheng Y, Kleissl L 等 2026 Aug 14 置信度 0.82
• When thermal shifts reshape function in intertidal seaweeds communities.
  Climate-driven changes are reshaping marine communities worldwide, yet its functional consequences for intertidal macroalgae remain poorly resolved. We investigated temporal trends in community thermal affinity and functional trait composition of low intertida…
  pubmed Martins M, Arenas F, Lindegren M, Vale CG 等 2026 Sep 置信度 0.82
• Emergence of an optrA-positive Enterococcus faecalis ST699 lineage in animal-derived foods in Beijing, China.
  Enterococci from animal-derived foods are key reservoirs for antimicrobial resistance (AMR) in the food chain. However, comparative genomic studies investigating the distribution of the oxazolidinone resistance gene optrA among food- and human-derived Enteroco…
  pubmed Liang C, Chen Y, Wu X, Chang R 等 2026 Aug 10 置信度 0.82
• Collaborative Rural Healthcare Delivery Through Innovative Readiness Training and Operation Health and Wellness: An Interprofessional Primary Care Model.
  BackgroundRural communities face persistent barriers to healthcare access, including workforce shortages, limited specialty services, and medication access constraints. Innovative Readiness Training (IRT), a Department of Defense program, partners with local c…
  pubmed Loika E, Hamilton J, Anderson J, Dominguez J 等 2026 Jan-Dec 置信度 0.82
• Early-Onset Colorectal Cancer in Neglected Populations: Would South Africa's Strategies Improve Screening, Management, and Genetic Insights Worldwide?
  Hereditary colorectal cancer (CRC) is recognized as an escalating global public health concern, yet it remains neglected among ethnic minority, indigenous, and/or understudied populations. This study aimed to evaluate the current genetic and molecular research…
  pubmed Yildiz S, Rebello G, Ramesar R 2026 Aug 14 置信度 0.82
• Consensus Lung Cell Reference: The Collaborative Cross-Consortium and Country Lung Cell Nomenclature Project (C3LCN). An Official American Thoracic Society Workshop Report.
  Rapid advances in single-cell technologies now allow measurement of thousands of transcripts and other molecular features of individual cells offering unprecedented insight into lung biology in homeostasis and in disease. The accelerated generation of multimod…
  pubmed Pryhuber GS, Nawijn M, Alam DA, Aronow B 等 2026 Aug 14 置信度 0.82
• Effectiveness of mass spectrometry and genomic analysis in the surveillance of nontuberculous Mycobacterium in Taiwan.
  Nontuberculous mycobacteria (NTM) are diverse, and species-level identification remains challenging in routine diagnostics. We analyzed NTM isolates collected at three regional centers of the National Taiwan University Hospital (NTUH) from 2019 to 2024 to asse…
  pubmed Chu H-W, Huang H-N, Shu C-C, Lee T-F 等 2026 Aug 14 置信度 0.82
• Incremental Value of Synthetic MRI Radiomics in Predicting Neoadjuvant Response in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.
  Purpose To evaluate the added value of a synthetic radiomics model (S-Radiomics) that integrates topologic and Hessian-based features with traditional radiomic features for predicting a pathologic complete response (pCR) in human epidermal growth factor recept…
  pubmed Chen S, Chen Y, Jin C, Zheng B 等 2026 Sep 置信度 0.82
• Multidrug resistance and genomic characteristics of nontypeable Haemophilus influenzae isolates from the respiratory tract of pediatric patients.
  Nontypeable Haemophilus influenzae (NTHi) is a common colonizer of the human upper respiratory tract and one of the major pathogens responsible for pediatric respiratory tract infections. Given the increasing severity of its multidrug resistance (MDR), this st…
  pubmed Wen Z, Kong Y, Ling M, Zhang J 等 2026 Aug 14 置信度 0.82
• BraMARS: An Interpretable Histopathology-Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited-Stage SCLC.
  Brain metastasis (BM) is a major cause of mortality in limited-stage small-cell lung cancer (LS-SCLC). Prophylactic cranial irradiation (PCI) reduces BM incidence but carries neurotoxicity and lacks individualized risk assessment. Here, we developed BraMARS, a…
  pubmed Yang Z, Wang T, Liu S, Zhang Z 等 2026 Aug 14 置信度 0.82
• Molecular Detection and Genotyping of Dientamoeba fragilis from Human Stool Specimens in Nineveh Governorate.
  We investigated Dientamoeba fragilis molecular distribution and genetic types among Nineveh Governorate patients with symptoms through SSU rRNA gene PCR amplification and sequencing.
  pubmed Fathi FK, Abdulwahhab IG, Jabar AT 2026 Apr-Jun 置信度 0.82
• Erratum to 'Genomic insights of a native bacterial consortium for wheat production sustainability' [Current Research in Microbial Sciences Volume 6, 2024, 100230].
  [This corrects the article DOI: 10.1016/j.crmicr.2024.100230.].
  pubmed Ayala Zepeda M, Valenzuela Ruiz V, Parra Cota FI, Chinchilla-Soto C 等 2026 置信度 0.82
• The Identification and Experimental Validation of Monocyte/Macrophage-Related Inflammatory Hub Genes in Ventilator-Induced Lung Injury.
  Objective This study aimed to identify monocyte/macrophage-related hub genes in ventilator-induced lung injury (VILI) by integrating transcriptomic analysis, immune infiltration analysis, weighted gene co-expression network analysis (WGCNA), protein-protein in…
  pubmed Liu W, Liu Y, Zeng Z 2026 Jul 置信度 0.82
• Erratum to 'Draft genome sequence of Agrobacterium pusense strain CMT1: A promising growth-promoting bacterium isolated from nodules of soybean (Glycine max L. Merrill) crops for the One Health approach in Paraguay' [Current Research in Microbial Sciences Volume 7, 2024, 100259].
  [This corrects the article DOI: 10.1016/j.crmicr.2024.100259.].
  pubmed Oggero AS, Borda MV, Pablos CMF, Leguizamón G 等 2026 置信度 0.82
• Erratum to 'Draft genome sequence of Agrobacterium pusense strain CMT1: A promising growth-promoting bacterium isolated from nodules of soybean (Glycine max L. Merrill) crops for the One Health approach in Paraguay' [Current Research in Microbial Sciences Volume 7, 2024, 100259].
  [This corrects the article DOI: 10.1016/j.crmicr.2023.100193.].
  pubmed Oggero AS, Borda MV, Pablos CMF, Leguizamón G 等 2026 置信度 0.82
• Activating laboratory surveillance response to the threat of H5N1 influenza in the Veterans Health Administration, 2024-25.
  The Veterans Health Administration (VHA) mobilized and adapted its established national infrastructure to enhance influenza surveillance during 2024-2025 highly pathogenic avian influenza (HPAI) A(H5N1) panzootic. Additionally, VHA's Public Health Reference La…
  pubmed Lucero-Obusan C, Chung JS, Oda G, Edson C 等 2026 置信度 0.82
• Experimental, Genomic, and Structural Evidence Supporting Putative PET-Hydrolases in Thermophilic Bacteria Isolated From Hot Springs in Cajamarca, Peru.
  Polyethylene terephthalate (PET) waste represents a major environmental challenge due to limited recycling solutions. Thermophilic bacteria from geothermal environments harbor diverse enzymatic machinery adapted to extreme conditions, offering promising biocat…
  pubmed Rivera-Jacinto MA, Rodríguez-Ulloa C, Briones-Ramírez SR, Quispe-Cruz B 等 2026 Aug 置信度 0.82
• Clinical, Genetic, and Endocrine Features of Bardet-Biedl Syndrome in a Pediatric and Adult Cohort.
  Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder characterized by clinical and genetic heterogeneity. Data on the prevalence of clinical manifestations and comorbidities in BBS, particularly in pediatric patients, are limited. This study aime…
  pubmed Hassan D, Salama M, Muthusamy K, Haqq AM 等 2026 Aug 13 置信度 0.82
• [Serum expression and combined diagnostic value of LBP, ITIH3, and CXCL7 in colorectal cancer].
  Objective: To screen for novel candidate serum biomarkers of colorectal cancer (CRC) using serum proteomics, and to evaluate the value of combining them with conventional tumor markers to construct a multivariable diagnostic model for the non-invasive auxiliar…
  pubmed Mo YY, Luo XR, Xing S, Zhou YC 2026 Aug 6 置信度 0.82
• [Preliminary study on the biological role of suppressor of Zeste 12 in hepatocellular carcinoma].
  Objective: To investigate the expression and function of Zeste 12 homolog (SUZ12) in hepatocellular carcinoma (HCC), and to preliminarily explore its biological role and underlying molecular mechanisms in HCC. Methods: This cell-based experimental study was co…
  pubmed Xuan JF, Ma LY, Guo RX, Li WQ 等 2026 Aug 6 置信度 0.82
• Clinical and Biologic Characterization of a 3-Level Centiloid-Based Classification of Amyloid PET.
  Amyloid PET is commonly interpreted using binary visual classification. However, quantitative assessment on the Centiloid scale identifies an intermediate range of amyloid burden not always captured by dichotomous interpretation. The biologic and clinical rele…
  pubmed Mathoux G, Boccalini C, Peretti DE, Scheffler M 等 2026 Aug 13 置信度 0.82
• Activity of Aztreonam-avibactam and Ceftazidime-Avibactam against Enterobacterales and Pseudomonas aeruginosa causing infections in patients hospitalized in hematology, oncology, and transplant units from United States medical centres (2019-2024).
  Immunosuppression increases the risks and severity of infections and is associated with a higher incidence of infection with multidrug-resistant (MDR) pathogens. We evaluated the antimicrobial susceptibility of Enterobacterales and Pseudomonas aeruginosa from …
  pubmed Sader HS, Castanheira M, Riccobene T, Kimbrough JH 等 2026 Aug 1 置信度 0.82
• Influence of metastatic patterns and initial disease burden on progression- free and survival outcomes in metastatic breast cancer.
  The relationship between the number of initial metastases and metastatic spread in terms of progression-free survival (PFS) and overall survival (OS) in metastatic breast cancer (mBC) remains poorly understood. This study aimed to identify key factors influenc…
  pubmed Albrecht F, Heidinger M, Zwimpfer TA, Nguyen-Sträuli BD 等 2026 置信度 0.82
• Turning the Sulfur Dial: Strategic Oxidation-State Manipulation in Modern Drug Discovery.
  Sulfur occupies a distinct niche in the toolkit of a medicinal chemist. Unlike oxygen, sulfur rationalized by ionic-resonance, negative hyperconjugation into low-lying σ* orbitals, and high polarizability of its 3p valence shell, accommodates the oxidati…
  pubmed Md Arshad AS, Singh R, Wiemer AJ 2026 Aug 13 置信度 0.82
• Prevalence and genetic characterization of Theileria annulata and Theileria orientalis in Post-abortion cattle.
  Tropical theileriosis is a significant health risk for cattle especially in tropical and subtropical regions where it contributes to high mortality rates and economic losses. Tick-borne protozoan parasites belonging to Theileria genera are responsible for this…
  pubmed Rasool M, Fatima M, Mulazim S, Bibi A 等 2026 Aug 13 置信度 0.82
• Whole exome sequencing identifies three novel variants and establishes the molecular diagnosis of ATP6V0A4-related distal renal tubular acidosis in a lebanese infant.
  Distal renal tubular acidosis (dRTA) is a rare inherited disorder characterized by impaired urinary acidification, leading to metabolic acidosis, hypokalemia, nephrocalcinosis, and growth impairment. Pathogenic variants in ATP6V0A4 are among the most common ge…
  pubmed Hachem T, Abou Jaoude P, Salem N, Chebly A 2026 Aug 13 置信度 0.82
• Genetic and phenotypic parameters for subclinical mastitis occurrence in pasture-based Girolando cows from a research herd in Southeast Brazil.
  Subclinical mastitis is still one of the most important health issues in dairy herds, leading to substantial economic losses due to reduced milk yield, treatment costs, and premature culling. Understanding the genetic basis of this disorder is essential in sup…
  pubmed Medeiros GC, Mussi CS, Ajibike AB, Berber Freitas BB 等 2026 Aug 置信度 0.82
• Genomic evolution and minority variant dynamics of RSV during the first season of nirsevimab implementation in Italy (2024-5).
  Respiratory syncytial virus (RSV) remains a leading cause of hospitalization despite the recent implementation of infant immunoprophylaxis programs. The inter- and intrahost levels of genetic variation across the genome have not been extensively investigated. …
  pubmed Romano G, Campagna R, Ferrari G, Pitrolo AMG 等 2026 置信度 0.82
• Low Prevalence of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) in a Hospital Triage Population in Tehran During 2024-2025.
  Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that is associated to adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) as two major diseases of the virus. Due to limited data on its p…
  pubmed Letafati A, Marvi SS, Hosori NA, Molaverdi G 等 2026 Aug 置信度 0.82
• A time‑dependent risk prediction model for distant metastasis in early‑stage breast cancer based on explainable ensemble learning: a retrospective cohort study.
  Distant metastasis is a leading cause of death in early-stage breast cancer, but current tools are imprecise or costly. This study aimed to develop an SHapley Additive exPlanations (SHAP)‑enhanced ensemble learning model using routine clinicopathologica…
  pubmed Wu H, Ren H, Liu S, Tang L 等 2026 Jul 31 置信度 0.82