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europepmc
2026
置信度 0.80
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Housekeeping genes (HKGs) and tissue-specific genes (TSGs) play essential roles in constitutive cellular maintenance and tissue specialization. However, their transcriptome-wide characterization remains largely unexplored in makhana (Euryale ferox Salisb.), an…
pubmed
Kumar P, Kumari R, Samal RR
2026
置信度 0.82
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Deep learning, as a pivotal branch of machine learning, has demonstrated remarkable potential in advancing crop science by effectively integrating genomics and phenomics. This review systematically outlines the application of diverse deep learning architecture…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Antimicrobial proteinaceous postbiotic substances (PS) and/or bacteriocins can beneficially influence animal health, as previously shown with enterocins from non-autochthonous enterococcal strains. Therefore, the effectiveness of PS 412, produced by our benefi…
pubmed
Lauková A, Focková V, Micenková L, Gancarčíková S 等
2026
置信度 0.82
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This study analyzed the correlation and differences between the gene polymorphisms of ATP-binding cassette B1 (ABCB1), which encode the efflux drug transporter P-glycoprotein, and the efficacy and plasma concentration of perampanel (PER) in patients with refra…
pubmed
Zhao T, Li HJ, Zhang HL, Yu J 等
2026
置信度 0.82
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pubmed
Zhou Y, Fang J, Chi Y, Wu L 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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When stress strikes, cells initiate adaptive responses, including perturbation of RNA splicing, modulation of nuclear RNA export, and formation of stress granules (SGs). Despite their central role, the composition and regulation of fungal SGs remain poorly und…
pubmed
Jeon H, Shin D, Son Y, Park J 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Wastewater surveillance has emerged as an effective tool for population-level pathogen monitoring. Its application to mutations associated with resistance to antivirals remains comparatively underdeveloped. We assessed the wastewater epidemiology framework usi…
pubmed
Lawal OU, Parreira VR, Overton AK, Knapp JJ 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Yersinia enterocolitica is a psychrotrophic foodborne bacterium that can proliferate at refrigeration temperatures and is frequently associated with animal-source foods, raising concerns about food safety and public health. However, genomic data on Y. enteroco…
pubmed
Kim D, Ryu S, Kim Y, Choi J 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors characterized by remarkable clinical heterogeneity and genetic complexity. Conventional diagnostic and therapeutic strategies have largely relied on catecholamine assessment, anatomical i…
pubmed
Zhou Y, Tong AL
2026
置信度 0.82
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europepmc
Raymond Dalgleish
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Pigs (Sus scrofa domesticus) are used as biomedical and preclinical models for their comparable anatomy, physiology, and neurodevelopment to humans. Angelman syndrome is a rare genetic neurodevelopmental disorder, caused by the loss of the maternal Ubiquitin p…
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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AI disclosure mandates have rapidly become standard in scientific publishing, a genuine success of scholarly self-governance. Yet across 10,000 bioRxiv preprints, disclosure tracks only modestly with code and data sharing. The next phase of policy should pair …
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Caffeine biosynthesis in tea plants (Camellia sinensis) is dynamically regulated by environmental cues; however, the mechanisms linking early drought signals to caffeine accumulation remain unclear. Here, we show that acute PEG-induced osmotic stress induces r…
pubmed
Zhang S, Chen Z, Yao X, Tian S 等
2026
置信度 0.82
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europepmc
2026
置信度 0.80
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Dengue remains a major public health concern in Indonesia. This study aimed to describe the epidemiology, clinical characteristics, immune responses, and genotype characterization of dengue virus (DENV) infections in Tangerang Regency, Indonesia. A year-round …
pubmed
Lokida D, Kosasih H, Susilowati S, Budiman NN 等
2026 Aug 31
置信度 0.82
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Streptococcus suis is a major zoonotic pathogen, and strains originating from clinically healthy pigs pose an increasingly serious threat to human health. This study investigated 315 S. suis isolates collected from clinically healthy pigs in Guangdong and Guan…
pubmed
Peng Z, Zhuang H, Liu R, Li F 等
2026 Aug 29
置信度 0.82
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Several dietary patterns have been associated with better health outcomes. However, the extent to which adherence to different so-called healthy diets overlaps, whether these dietary patterns are equally beneficial, and whether they are associated with similar…
pubmed
Tavares JF, Liu D, Talevi V, Eichelmann F 等
2026 Aug 29
置信度 0.82
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Epilepsy represents a highly prevalent neurological disorder with a significant genetic component, particularly implicating ion channel genes, including SCN1A. In this study, 431 individuals with heterogeneous paediatric-onset epilepsy phenotypes were assessed…
pubmed
Szalai R, Till A, Galimurka K, Banfai Z 等
2026 Aug 29
置信度 0.82
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To increase the activity of cannabidiolic acid synthase (CBDAS) and its expression levels in yeast, this study focused on the CBDAS G183V-N482W mutant. Using computer-aided techniques and literature reviews, four mutation sites were further identified, resulti…
pubmed
Dai L, Lin J, Kang Y, Chi J 等
2026 Aug 29
置信度 0.82
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Short tandem repeat (STR) expansion is a major genetic mechanism underlying numerous neurogenetic disorders. However, traditional PCR amplification and short-read next-generation sequencing-based methods often fail to detect large-scale, complex expansions and…
pubmed
Lee S, Jung C, Kim M, Kim N 等
2026 Aug 29
置信度 0.82
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Understanding the impact of risk-reducing hysterectomy (RRH) on health-related quality-of-life is essential for informed decision-making around endometrial cancer prevention and has not been previously investigated. This study aimed to estimate health-related …
pubmed
Oxley SG, Lake M, Dibden A, Whenham T 等
2026 Aug
置信度 0.82
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To investigate the epidemiological characteristics of CRKP responsible for BSIs in Hebei Province, China.
pubmed
Hao Y, Li J, Zhang J, Xie S 等
2026
置信度 0.82
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To quantify the per-patient-per-month (PPPM) cost for each phase of care in higher-risk myelodysplastic syndromes (HR-MDS) and the overall cost of a base-case (illustrative) non-curative management pathway followed by a patient with HR-MDS in England.
pubmed
Williamson J, Searle EJ, Louramo E, Hughes R 等
2026 Aug 28
置信度 0.82
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PREVENT 1 is a nationwide, prospective Swedish infant cohort established to characterise gut microbiome development during the first 2 years of life and to relate microbial trajectories to feeding, infections, growth and everyday well-being. The study integrat…
pubmed
Orwa S, Vlajic M, Cavani E, Devall AE 等
2026 Aug 28
置信度 0.82
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Streptococcus pyogenes causes a broad spectrum of invasive and non-invasive infections globally, associated with high morbidity and mortality. In mainland China, distribution of the emm genotype has shifted markedly over recent decades, with emm12 emerging as …
pubmed
Liu M, Cai Y, Xu Q, Dong Z 等
2026 Aug 24
置信度 0.82
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BRCA1 and BRCA2 gene mutations are major contributors to hereditary breast and ovarian cancer syndrome (HBOC). While mutation prevalence has been well-characterized in high-income countries, African populations remain underrepresented in genomics cancer resear…
pubmed
Milambo JPM, Chitha WW
2026 Aug 1
置信度 0.82
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To investigate the clinical characteristics of a fetus with Short-rib thoracic dysplasia 8 with or without polydactyly (SRTD8) due to variants of DYNC2I1 gene.
pubmed
Liu Y, Han C, Zhang Y, Yan L 等
2026 Sep 10
置信度 0.82
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To explore the pathogenicity and prenatal counseling strategies for five Chinese pedigrees harboring a hemizygous c.-32C>G (NM_001139500.2) variant of fibroblast growth factor 13 (FGF13) gene.
pubmed
Huang J, Wang J, Zhou L, Yang H 等
2026 Sep 10
置信度 0.82
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Liquid biopsy is a transformative tool for precision oncology, yet its clinical use remains variable across healthcare systems, and barriers to its implementation are poorly characterized. This survey aims to assess perceptions and practices related to liquid …
pubmed
Nicolò E, Singhal S, Saldanha EF, Jin X 等
2026 Sep
置信度 0.82
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Feline coronavirus (FCoV), the etiological agent of feline infectious peritonitis (FIP), represents a major clinical and economic challenge in feline populations worldwide. However, molecular prevalence and genetic diversity data from India remain limited, and…
pubmed
Vijayalakshmi R, Raja P, Parthiban M, Chandrasekar M 等
2026 Jun
置信度 0.82
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Animal-mediated pollination is essential to our food system: around 75% of crops worldwide depend, at least partially, on floral visitations by animals for their production. Crop pollinators, primarily insects, display an increasing role in global crop yields …
pubmed
Aubouin L, Lécrivain A, Coussy B, Chabert S 等
2026 Aug
置信度 0.82
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Metastatic castration-resistant prostate cancer has a poor prognosis. Although olaparib has demonstrated efficacy in patients with BRCA1/2 mutations, real-world data in Japanese patients remain limited. We aimed to evaluate the efficacy and safety of olaparib …
pubmed
Nukaya T, Naiki T, Watanabe H, Nakane K 等
2026 Sep
置信度 0.82
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A nationwide investigation identified 426 patients with Wickerhamomyces anomalus fungal cultures in South Africa; most cases clustered during May-November 2023. Case-patients lacked evidence of infection, indicating a pseudo-outbreak. Genomic and laboratory an…
pubmed
Maluleka C, Ismail H, Shuping L, Mpembe R 等
2026 Sep
置信度 0.82
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Wickerhamomyces anomalus is a yeast rarely involved in human invasive fungal diseases (IFD). We retrospectively analyzed 44 episodes of W. anomalus IFD in France during 2012-2024. Injecting drug use (IDU) was the main risk factor among 26/35 (74.3%) incident c…
pubmed
Lefranc M, Pain A, Dalle F, Baudino P 等
2026 Sep
置信度 0.82
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Two decades after the introduction of induced pluripotent stem cell (iPSC) technology, the field has evolved from a seminal biological discovery into a transformative clinical platform. This maturation reflects a convergence of nonintegrating cellular reprogra…
pubmed
Lee J, Herron T, Studer L, Mummery CL 等
2026 Aug 27
置信度 0.82
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Aedes notoscriptus are mosquito vectors implicated in transmission of Mycobacterium ulcerans. This bacterium causes a destructive infection of skin and soft tissue called Buruli ulcer. Here we ran a randomized controlled trial in an urban Buruli ulcer endemic …
pubmed
Paris V, Buultjens AH, Bell N, Schmidt TL 等
2026 Sep
置信度 0.82
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Mycobacterium abscessus infections are frequently drug resistant and can cause severe disease, particularly among vulnerable populations in healthcare settings. In June 2024, a cluster of M. abscessus infection cases was reported at a hospital in Maryland, USA…
pubmed
Ludmer S, Duwell M, Harris T, Leekha S 等
2026 Sep
置信度 0.82
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Evaluate the 2025 ESCMID-EFISG webinar series to assess digital education as a scalable, equitable model for global professional development in medical mycology.
pubmed
Salmanton-García J, Siewert L, Richardson M, Vena A
2026
置信度 0.82
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Photobiocatalysis integrates enzymatic catalysis with photochemistry, enabling challenging radical transformations with high selectivity under mild conditions. Early developments in this field were largely driven by the discovery that enzyme-bound cofactors ca…
pubmed
Bai Z, Zhou Y, Zhao H
2026 Aug 27
置信度 0.82
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Toxoplasma gondii is a globally distributed zoonotic parasite, and dromedary camels are important intermediate hosts in arid and semi-arid regions. However, information on T. gondii exposure in camels is lacking in Mauritania, which harbors one of the largest …
pubmed
Lemrabott MAO, Aroussi A, Yousfi S, Khelifi Touhami NA 等
2026 Aug 19
置信度 0.82
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Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) bo…
pubmed
Do TT, Maccora J, Wallace R, Aedo-Lopez V 等
2026 Aug 3
置信度 0.82
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We previously demonstrated the usefulness of circulating tumor DNA (ctDNA) in blood for assessing tumor burden for esophageal squamous cell carcinoma (ESCC). We also found that endoscopic response evaluation predicted the prognosis of ESCC patients. In this st…
pubmed
Hoshi Y, Matsuda S, Nakamura K, Kawakubo H 等
2026 Aug 27
置信度 0.82
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This study aimed to monitor the resistance status of adult Aedes albopictus ( Ae. albopictus ) to commonly used insecticides in Jining (Shandong Province), Guangzhou (Guangdong Province), and Haikou (Hainan Province), and to provide evidence for improving vect…
pubmed
Xu N, Pan X, Peng K, Yin H 等
2026
置信度 0.82
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Human metapneumovirus (hMPV) is a leading cause of acute respiratory infections worldwide, yet whole-genome surveillance data remain scarce in eastern China. The evolutionary dynamics of G gene duplication variants and their molecular drivers are poorly charac…
pubmed
Ji X, Liu Z, Cai X, Liang R 等
2026
置信度 0.82
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Biallelic variants in VPS41, encoding a subunit of the HOPS complex, cause autosomal recessive spinocerebellar ataxia 29 (SCAR29), a rare neurodevelopmental disorder with an incompletely defined phenotypic and molecular spectrum.
pubmed
Nakamura N, Nishio Y, Nyuzuki H, Fukushima A 等
2026 Sep
置信度 0.82
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Infections are frequent in critically ill patients with earthquake-associated crush injury (CI) and contribute to poor outcomes, yet the immune pathways underlying posttrauma susceptibility remain poorly defined. We investigated longitudinal changes in damage-…
pubmed
Yuksel RC, Demir BS, Houran MA, Asan M 等
2026
置信度 0.82
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The 2022-2024 mpox outbreak in Europe was dominated by MPXV Clade IIb and generally mild, but recent Clade I/Ib detections and early local transmission have changed preparedness needs. We performed a PRISMA-ScR scoping review of European mpox evidence from 202…
pubmed
Sofos F, Pana ZD, Drikakis D
2026 Aug 7
置信度 0.82
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Mammalian orthoreoviruses (MRVs) are segmented, double-stranded RNA viruses that infect a broad range of mammalian hosts, including humans. Although MRVs have been detected in wastewater in parts of Southeast Asia, they have not previously been reported in U.S…
pubmed
Collins JP, Mechikoff MA, Pressley TA, Jarriel CR 等
2026 Aug 6
置信度 0.82
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Sheep- and goatpox are highly contagious, transboundary viral diseases caused by capripoxviruses (CaPV), severely impacting small ruminant production and resulting in significant economic losses. Our study aimed to analyze the spatiotemporal SGP distribution u…
pubmed
Sprygin A, Korennoy F, Atovullozoda R, Babiuk S 等
2026 Aug 3
置信度 0.82
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Oropouche virus (OROV), an Orthobunyavirus of the Peribunyaviridae family, is usually transmitted to humans by biting midges, while, to date, cases of human-to-human transmission have not been reported. Although OROV's clinical manifestation is usually charact…
pubmed
Rizzo L, Alessandri G, Gori Savellini G, Caldrer S 等
2026 Jul 28
置信度 0.82
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Climatic changes are heavily affecting the sustainability of vegetable crops crucial for food supply worldwide, mainly in subtropical countries. One of the main threats to food security is the spread of diseases caused by plant viruses, favored by irregular ra…
pubmed
Amoia SS, Giampetruzzi A, Neto FFS, António LF 等
2026 Jul 26
置信度 0.82
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Vibrio parahaemolyticus is a leading cause of seafood-associated gastroenteritis, yet the ecological and genomic significance of environmental populations as potential reservoirs remains incompletely characterized. From May to October 2024, 108 water samples w…
pubmed
Xu J, He Y, He P
2026 Aug 20
置信度 0.82
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Genome mining of the marine-derived Streptomyces sp. S42 uncovered a type II polyketide synthetase (T2 PKS) biosynthetic gene cluster (BGC) harboring a gene for 3-ketoacyl-ACP synthase III (KAS III), a hallmark of non-acetate starter unit incorporation, sugges…
pubmed
Hao X, Yang M, Yan P, Shen Q 等
2026 Jul 30
置信度 0.82
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Here we report the draft genome sequences of three Enterococcus faecalis strains, LAB1, LAB10, and LAB11, isolated from the pond water of a tilapia ( Oreochromis niloticus ) aquaculture farm at the University Nangui Abrogoua, Abidjan, Ivory Coast. These strain…
pubmed
Akinyemi MO, Coulibaly WH, Sakia Mian TM, Popescu PA 等
2026 Jul 29
置信度 0.82
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Acinetobacter baumannii is a formidable nosocomial pathogen responsible for severe hospital-acquired infections. This study aimed to investigate the relationship between genotypic and phenotypic resistance profiles in 36 non-duplicate invasive A. baumannii iso…
pubmed
Marinova-Bulgaranova T, Hristova P, Marinovska P, Balgaranov N 等
2026 Jul 24
置信度 0.82
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Listeria monocytogenes is a leading cause of foodborne mortality in the European Union, with ready-to-eat (RTE) meat products representing a primary transmission vehicle. Traditional dry-cured and fermented meat products, produced under small-scale artisanal c…
pubmed
Orahovac A, Zuber Bogdanović I, Nikolić M, Martinović A 等
2026 Jul 23
置信度 0.82
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To characterize the transcriptomic dynamics underlying shell hardening in Macadamia integrifolia , RNA sequencing was performed on pericarp and shell tissues collected at three key developmental stages. A total of 18 libraries were generated, yielding 125.19 G…
pubmed
Long Q, Li Y, Geng J, Gong L 等
2026 Aug 11
置信度 0.82
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Shiga toxin-producing Escherichia coli (STEC) is a zoonotic pathogen of global relevance whose persistence in food processing environments is frequently mediated by biofilm formation. The acquisition of stx prophages and associated regulatory mutations can imp…
pubmed
Castro VS, Bumunang EW, Yang X, Porto YD 等
2026 Jul 31
置信度 0.82
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The human placenta plays a critical role as an immune and mechanical barrier. Notwithstanding, viral pathogens can still cross this barrier. Previously, differential gene expression has been described for protein-coding genes in human-induced-pluripotent-stem-…
pubmed
Souza-Lopes T, Fischer-Carvalho A, Freire CF, Poli PJ 等
2026 Aug 15
置信度 0.82
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Katak, a traditional Bulgarian fermented dairy product distinguished by its unique sensory characteristics and extended shelf life, represents a valuable source of autochthonous microorganisms whose functional and genomic properties remain insufficiently explo…
pubmed
Dobreva L, Atanasova N, Donchev P, Krumova E 等
2026 Aug 7
置信度 0.82