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• Integrating NRG1 and OXT Polymorphisms, Maternal Psychological Vulnerability, and Obstetric-Neonatal Outcomes: A Genotype-Phenotype Pilot Study.
  Background and Objectives: Maternal psychological vulnerability during pregnancy is associated with adverse obstetric and neonatal outcomes, but the contribution of candidate genetic markers remains insufficiently defined. This exploratory pilot case-control s…
  pubmed Socol ID, Farcaș SS, Socol FG, Dumitriu BI 等 2026 Aug 14 置信度 0.82
• Antibiotic Resistance Genes in Dust from Kindergarten Environments: A Systematic Review of Occurrence, Diversity, Determinants, and Exposure Implications.
  Kindergarten environments combine high microbial exposure with increased immunological vulnerability, yet antibiotic resistance genes (ARGs) in kindergarten dust remain poorly characterized. This systematic review synthesized evidence on the occurrence and pot…
  pubmed Makkaew P, Bumyut A, Megasari NLA, Precha N 2026 Aug 9 置信度 0.82
• Geographical Distribution and Molecular Characterization of Dirofilaria spp. in Dogs Across Kazakhstan.
  Canine dirofilariosis caused by Dirofilaria immitis and Dirofilaria repens is a vector-borne zoonotic infection of considerable veterinary and public health importance. Despite reports of the circulation of Dirofilaria spp. in neighboring countries, data on th…
  pubmed Almysheva T, Uakhit R, Smagulova A, Sembaeva Z 等 2026 Aug 20 置信度 0.82
• Disentangling the Interplay Among Genetics, Feeding and Production System Characteristics on Methane Emissions in Holstein Friesian Dairy Cows.
  Methane (CH 4 ) emissions from dairy cattle contribute substantially to agricultural greenhouse gas production and are influenced by genetic, physiological, environmental and management-related factors. The present study investigated CH 4 -related traits and g…
  pubmed Aufmhof L, Fehmer L, König S 2026 Aug 10 置信度 0.82
• Molecular Mechanisms in Responses to Combined Stresses in Strawberry.
  Strawberry is a globally important yet stress-sensitive crop, increasingly threatened by combined abiotic and biotic stresses. Unlike single stresses, combined stresses elicit unique, non-additive responses through complex signaling and gene regulatory network…
  pubmed Zhang X, Xia X, Wang S, Sun Q 等 2026 置信度 0.82
• A Comprehensive Understanding of DCTPP1 as an Emerging Therapeutic Target in Liver Cancer.
  Balanced control of intracellular deoxyribonucleoside-triphosphate (dNTP) pools is crucial for accurate DNA replication and genome stability. Deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) is a cytosolic nucleotide-sanitizing enzyme that selectively hyd…
  pubmed Ka HI, Jang SH, Kim HS, Jung HS 等 2026 Jul 29 置信度 0.82
• Public Awareness of Genetic Diseases, Preventive Screening, and Genetic Healthcare Services in the Qassim Region, Saudi Arabia: A Cross-Sectional Study.
  Background: Genetic diseases pose a significant public health issue in Saudi Arabia, driven by relatively high prevalence and factors such as consanguineous marriage. Increasing public awareness and understanding are crucial to improving prevention, early dete…
  pubmed Aldharee H, Almutari G, Alofi A, Alqubays M 等 2026 Aug 14 置信度 0.82
• DNA Methylation Dynamics in Eisenia andrei Regeneration: The Effects of Time, Region, and a Hypomethylating Agent.
  The impact of epigenetic mechanisms on molecular and cellular processes of regeneration remains a less-investigated field, especially concerning earthworm segment restoration. To evaluate distinct methylated cytosines under different conditions, earthworm segm…
  pubmed Brotzki da Costa C, Németh P, Engelmann P 2026 Aug 14 置信度 0.82
• Molecular Characterization of the Mycobacterium tuberculosis Complex in Humans and Cattle.
  Zoonotic tuberculosis (TB) remains a persistent public health challenge worldwide. It is particularly common in settings with close human-livestock-environment interactions. In Tanzania, progress toward TB control is increasingly threatened by multidrug-resist…
  pubmed Ulomi JS, Mbelele PM, Ngowo J, Mtweve D 等 2026 Aug 10 置信度 0.82
• Emergence and Dissemination of NDM+OXA-48-like Co-Producing Klebsiella pneumoniae in a Regional Healthcare Network: Seven-Year Surveillance from Latium, Italy.
  Background/Objectives : The epidemiology of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) in Europe is evolving towards an increasing contribution of metallo-β-lactamases (MBLs). In particular, co-production of New Delhi metallo-β-lactamase (N…
  pubmed Venditti C, Rotondo C, Maestripieri C, Caparrelli C 等 2026 Aug 10 置信度 0.82
• Combating Carbapenem-Resistant Enterobacterales: Comparative In Vitro Efficacy of Aztreonam-Avibactam and Ceftazidime-Avibactam and Distribution of Carbapenemase Genes.
  Background: Carbapenem-resistant Enterobacterales (CRE) are a major therapeutic challenge, particularly in settings where metallo-β-lactamases are prevalent. Aztreonam-avibactam (AZA) may provide activity against metallo-β-lactamase-producing isola…
  pubmed Yaşar Duman M, Kanat M, Tanrıverdi ES, Çilli F 等 2026 Jul 25 置信度 0.82
• Genome-Wide Characterization of the WIP Transcription Factor Gene Family in Soybean and Physiological Responses to Salt Stress.
  Soybean ( Glycine max ) productivity is increasingly constrained by soil salinity. WIP transcription factors, a subfamily of C2H2-type zinc finger proteins, regulate cell division, differentiation, and tissue patterning in several plant species, but this gene …
  pubmed Gao T, Yan S, Lamlom SF, Hong H 等 2026 Aug 18 置信度 0.82
• Transcriptomic Markers of Immunosenescence in Cynomolgus Macaques: A Pilot Study.
  One of the key hallmarks of aging is the age-related decline in immune system function, accompanied by a chronic low-grade inflammation, or "inflammaging". Simultaneously, a reduced capacity of immune cells to recognize and eliminate pathogens, along with immu…
  pubmed Petrova VM, Bulgin DV, Radomskaya EY, Shevelov VA 等 2026 Aug 13 置信度 0.82
• Genome-Wide Association Mapping of Chlorophyll Dynamics and Seed Weight Under Contrasting Nitrogen Conditions in Soybean.
  Background : Nitrogen (N) availability is an important factor affecting soybean growth, photosynthetic capacity, and seed development. Identification of genomic regions associated with N-responsive traits may enable the development of cultivars with enhanced p…
  pubmed Sleigh R, Kantartzi SK 2026 Aug 6 置信度 0.82
• Distribution of ACTN3 R577X, MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms in 564 School-Aged Children in Beijing: A Cross-Sectional Study.
  Beijing's 2024 school physical education reforms have substantially increased activity demands on children, yet population-level genotype data for Chinese schoolchildren remain scarce.
  pubmed Peng X, Ding W, Kang X, Yan Y 等 2026 Jul 29 置信度 0.82
• Foretell Ovary: A Blood-Based Ensemble Algorithm Integrating Tumor-Educated Platelet RNA and Routine Hematology for Non-Invasive Ovarian Cancer Screening.
  Background: Ovarian cancer is the most lethal gynecologic malignancy, and CA-125 has limited early-stage sensitivity. We developed and evaluated Foretell Ovary, an ensemble machine-learning classifier that integrates tumor-educated-platelet RNA markers and rou…
  pubmed Ahn E, Kim SI, Kim S, Kim H 等 2026 Aug 14 置信度 0.82
• Cathepsin V (CTSV) Shapes the Epigenetic-Immune Landscape of Bladder Cancer and Emerges as a Noninvasive Biomarker.
  The aim of this study was to perform a comprehensive characterization of CTSV regulation in bladder cancer (BC) and its association with clinicopathological features, prognosis, and tumor stroma modulation using multi-omics databases.
  pubmed Ferreira WAS, Marchi FA, Vitiello GAF, Villacis RAR 等 2026 Sep 置信度 0.82
• KRAS and TP53 Circulating Tumor DNA are Prognostic in Localized Pancreatic Cancer.
  Pancreatic ductal adenocarcinoma (PDAC) carries high mortality despite neoadjuvant chemotherapy (NAC) and surgical resection, creating an urgent need for prognostic biomarkers to guide treatment. We aimed to determine whether circulating tumor DNA (ctDNA) dete…
  pubmed Sridalla K, Vitello DJ, Cox M, Masnyk L 等 2026 Aug 26 置信度 0.82
• Spatial clustering and transmission networks of multidrug-resistant tuberculosis in Rwanda: a national retrospective genomic and spatial epidemiological study.
  Approximately 96% of rifampicin resistance/multidrug-resistant tuberculosis (RR/MDR-TB) cases in Rwanda result from direct transmission rather than acquired resistance. However, the nationwide spatial distribution and transmission dynamics of RR/MDR-TB remain …
  pubmed Cuella-Martin I, Hakizayezu F, Mulders W, Niyompano H 等 2026 Aug 26 置信度 0.82
• An Extremely Rare ZP4 Missense Variant in a Patient with Abnormal Zona Pellucida Morphology and Female Infertility: A Case Report.
  Background and Clinical Significance: The oocyte zona pellucida (ZP) is an extracellular glycoprotein matrix with essential roles in oogenesis, fertilization, and early embryonic development. Abnormal ZP morphology is associated with female infertility and adv…
  pubmed Arakelyan N, Reshetov D, Yakovenko S, Kosorukova I 等 2026 Aug 9 置信度 0.82
• Resistance to SDHI Fungicides in Monilinia fructicola Field Isolates Is Associated with Amino Acid Substitutions Across SDH Subunits.
  Brown rot, caused by Monilinia fructicola , is the most destructive pre- and postharvest fruit rot of peach worldwide. In 2024, a disease outbreak occurred in a South Carolina orchard despite a rigorous chemical management program consisting of preharvest appl…
  pubmed Gelain J, Wesche J, Trotter EK, Beger M 等 2026 Aug 26 置信度 0.82
• Marine-Derived Rare Actinomycetes: Metabolites and Their Biosynthesis.
  Marine-derived rare actinomycetes are a chemically prolific yet underexploited source of structurally diverse secondary metabolites. In this review, rare actinomycetes are operationally defined as marine-derived non- Streptomyces actinomycetes that remain comp…
  pubmed Son J, Park HS, Jung SH, Heo MS 等 2026 Aug 19 置信度 0.82
• The Underexplored Genus Microbispora: A Treasure Trove of Secondary Metabolites with Diverse Chemistry, Potent Bioactivities, and Biosynthetic Insights.
  Rare actinomycetes have emerged as important yet underexplored reservoirs for the discovery of novel bioactive compounds. Microbispora , a genus of rare actinomycetes, is widely distributed across diverse ecological niches, including terrestrial soils, marine-…
  pubmed Chen M, Song Q, Zhang Z, Liu S 等 2026 Jul 29 置信度 0.82
• AI-Assisted Spatial Metabolic Engineering in Plants: Integrating Flux Design, Spatial Omics, and Synthetic Biology.
  Background: Plant synthetic biology reprograms metabolic networks for the sustainable production of high-value compounds. Recent computational advances incorporate machine learning to accelerate the design-build-test-learn (DBTL) cycle, enabling more predictab…
  pubmed Chen H, Yang J, Du M 2026 Jul 23 置信度 0.82
• Systematic Identification of the GH28 Gene Family in the Pathogenic Fungus Cytospora pyri and Functional Verification of the Candidate Virulence Gene VP1G_08835.
  Fragrant pear canker, caused by Cytospora pyri , is a major branch disease that reduces the productivity and longevity of Korla fragrant pear orchards in Xinjiang, China. During infection and lesion expansion in woody tissues, C. pyri must breach the host cell…
  pubmed Xue Z, Peng S, Liu Z, Duan Y 等 2026 Aug 1 置信度 0.82
• A Parsimonious Ultrasound Radiomics and Ki-67 Model for Estimating MammaPrint Risk Categorization in HR+/HER2- Early Breast Cancer.
  The 70-gene signature (70-GS; MammaPrint) assay is useful for prognosis assessment in HR+/HER2- early breast cancer, but limited accessibility motivates development of noninvasive alternatives. We retrospectively enrolled 219 women with preoperative grayscale …
  pubmed Gao Y, Luo Y, Niu Z, Zhou M 等 2026 Aug 4 置信度 0.82
• Trastuzumab Deruxtecan in Metastatic Urothelial Carcinoma with NGS-Detected ERBB2 Amplification: A Four-Patient Real-World Case Series.
  Background: Next-generation sequencing (NGS)-detected ERBB2 amplification occurs in a subset of urothelial carcinomas, but its role as a treatment-selection marker for trastuzumab deruxtecan (T-DXd) remains uncertain. Methods: We retrospectively reviewed four …
  pubmed Di Lorenzo G, Di Lorenzo S, Verde A, Strianese O 等 2026 Jul 30 置信度 0.82
• Gross Total Resection and Recurrence-Free Survival in Diffuse Gliomas: A Single-Center Cohort Study from Eastern Europe.
  Background/Objectives: The independent contribution of extent of resection (EOR) to early recurrence in diffuse gliomas remains debated, as crude analyses are confounded by tumor biology, and real-world data from Eastern European centers are scarce. Methods: W…
  pubmed Blidaru TC, Zaharia MC, Mitrea D, Marin RM 等 2026 Aug 20 置信度 0.82
• Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis.
  IFNγ and IL-4, the canonical Th1 and Th2 cytokines, typically induce opposing macrophage polarization. Beyond their frequent coexistence and mutual antagonism in pathological settings, a synergistic crosstalk may also exist and remains to be defined. Thr…
  pubmed Varga Z, Poscher A, Váradi EA, Cinege G 等 2026 Aug 24 置信度 0.82
• Mitochondrial DNA A3243G variant-associated MELAS: Recent advances in clinical trials, therapeutic interventions, and disease-modifying strategies.
  Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, most often caused by the m.3243A>G mitochondrial DNA variant, represents one of the most clinically significant inherited mitochondrial disorders. This variant disr…
  pubmed Chu KY 2026 Aug 31 置信度 0.82
• Mutation Patterns Define Clinical Heterogeneity in Acute Myeloid Leukemia.
  Acute myeloid leukemia (AML) is a molecularly heterogeneous malignancy where next-generation sequencing (NGS) has revolutionized risk stratification and treatment paradigms. However, the interplay between mutation cooperativity, clinical phenotypes, and bioche…
  pubmed Xu Z, Zheng Y, Zheng Y, Yao Y 等 2026 置信度 0.82
• Correction: 5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy.
  [This corrects the article DOI: 10.3389/fncel.2024.1338502.].
  pubmed Jiang S, Sydney EJ, Runyan AM, Serpe R 等 2026 置信度 0.82
• Molecular predictors of recurrence in vestibular schwannomas: a transcriptomic and RT-qPCR analysis.
  Vestibular schwannomas (VS) are benign tumors with variable clinical behavior. Recurrence after surgery is uncommon yet sometimes aggressive. Reliable molecular predictors of recurrence are lacking, and the correlation between genotype and phenotype is weak. T…
  pubmed Ruiz-García C, Franco-Caspueñas S, Rodríguez-de la Rosa L, Martinez-Glez V 等 2026 Aug 26 置信度 0.82
• Emergence of a Tn7-associated blaVIM-1 within IncC plasmids in ST46 Providencia stuartii from Northern Italy.
  To characterize the genomic features and resistance determinants of carbapenem-resistant Providencia stuartii isolates circulating in Northern Italy, with a focus on the genetic context of blaVIM-1.
  pubmed Marchetti VM, Piscopiello F, Petrizzi I, Caltagirone MS 等 2026 Aug 25 置信度 0.82
• Tularemia: a re-emerging zoonosis.
  Tularemia, caused by Francisella tularensis, presents cycles of re-emergence in the Northern Hemisphere. In 2024-2025, increased incidence has been documented in Central Europe (Austria: 117 cases; Slovenia: 38 cases; France: 150 cases) and Spain (Castile and …
  pubmed Hernández M, Oteo JA, Eiros JM 2026 Aug 25 置信度 0.82
• Periodontal Bacteria Proteomics in Thrombi from Ischemic Stroke Patients.
  To characterize periodontal bacterial proteins in ischemic stroke thrombi and explore differences according to stroke etiology.
  pubmed Gayo F, Bravo S, Moldes J, Pena C 等 2026 Aug 25 置信度 0.82
• Genomic Epidemiology of Clostridioides difficile Infection: A cgMLST Analysis.
  To characterise the genomic epidemiology of Clostridioides difficile infection (CDI) at Letterkenny University Hospital (LUH) using core-genome Multi Locus Sequence Typing (cgMLST), quantify true nosocomial transmission, distinguish relapse from reinfection, a…
  pubmed Sarma JB, Murray V, McFadden C 2026 Aug 20 置信度 0.82
• Occurrence and Molecular Characterization of Alphaherpesvirus in Psittacines in the State of Mato Grosso.
  The Alphaherpesvirinae subfamily belongs to the Orthoherpesviridae family, whose viruses are characterized by rapid replication and the ability to establish latent infection in host cells. These viruses cause important avian diseases such as Marek's disease, i…
  pubmed da Silva TR, Costa MTDS, Moraes DFDSD, Vani CRA 等 2026 置信度 0.82
• Genome-wide association study reveals putative genetic determinants of longitudinal immune responses to avian influenza and Newcastle disease in chickens.
  Avian Influenza virus (AIV) and Newcastle disease virus (NDV) are highly contagious immunosuppressive pathogens that cause high mortality rates and economic losses in the global poultry industry. Although vaccination to enhance the host antibody response remai…
  pubmed Berihulay H, Luo W, Lao A, Chuxiao L 等 2026 Aug 11 置信度 0.82
• Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.
  Transarterial chemoembolisation (TACE), a standard treatment for embolisation-eligible hepatocellular carcinoma (HCC), induces tumour immune responses. Single tremelimumab regular interval durvalumab (STRIDE) is a standard treatment in advanced HCC. In this ph…
  pubmed Kudo M, Abou-Alfa GK, Ren Z, Heo J 等 2026 Sep 置信度 0.82
• Safety assessment of tenecteplase for the treatment of acute myocardial infarction and ischemic stroke, and identification of key genes.
  Tenecteplase (TNK) is used for the treatment of acute myocardial infarction (AMI) and ischemic stroke (IS). This study provided a reference for clinical safety by analyzing adverse drug events (ADEs) with TNK from the Food and Drug Administration Adverse Drug …
  pubmed Cheng H, Chen Y, Li H, Zhong D 2026 Aug 24 置信度 0.82
• Epidemiological, Clinical and Viral Genomic Features of Influenza Virus Infections Among Pilgrims During the Grand Magal of Touba Over 7 Years (2018-2024).
  Large international gatherings such as the Grand Magal of Touba in Senegal may favor influenza A/B virus (IABV) transmission. We analyzed IABV genomes from human samples collected during the event in 2018-2024. Next-generation sequencing was performed for 190 …
  pubmed Diouf C, Diallo S, Ouaddane I, Ndiaye D 等 2026 Aug 置信度 0.82
• CpG content contributes to tissue-resident macrophage enhancer selection.
  Tissue-resident macrophages acquire specialized identities through transcription factor networks operating in distinct chromatin environments. Early growth response 2 (EGR2) contributes both to alveolar macrophage identity and to interleukin (IL)-4-driven pola…
  pubmed Bojcsuk D, Varga Z, Kolostyák Z, Tzerpos P 等 2026 Aug 24 置信度 0.82
• Occurrence of multidrug-resistant bacteria and clinically important β-lactamase resistance genes in giant freshwater prawn (<em>Macrobrachium rosenbergii</em>) aquaculture ponds in Thailand.
  The rapid expansion of giant freshwater prawn ( Macrobrachium rosenbergii ) aquaculture has raised concerns regarding the emergence and dissemination of antimicrobial resistance (AMR) in aquatic ecosystems. However, information regarding antibiotic-resistant b…
  pubmed Petjul K, Khunsanit P, Boonmee T, Tankrathok A 等 2026 Jul 31 置信度 0.82
• HIF-1α-mediated regulation of ATG7 and KDM5C in ferroptosis.
  Hypoxia, a hallmark of the solid tumor microenvironment (TME), drives malignant progression and confers therapy resistance. In liver cancer, the hypoxia-inducible factor-1&#x3b1; (HIF-1&#x3b1;) has been implicated in suppressing ferroptosis, a key mechanism of…
  pubmed Tian K, Chang P, Yang X, Chen D 等 2026 Aug 23 置信度 0.82
• Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.
  Total mesorectal excision (TME) is the standard treatment for most early-stage and intermediate-stage rectal cancer but can cause substantial perioperative morbidity, functional impairment, and reduced quality of life. We assessed whether long-course chemoradi…
  pubmed Bach SP, Sebag-Montefiore D, Homer V, Gilbert A 等 2026 Sep 置信度 0.82
• Using High-Dimensional Environmental Covariates to Study Genotype by Environment Interaction for Reproductive Traits in Duroc Boars.
  We investigated the potential of incorporating grid-cell-based environmental covariates (ECs) in the genetic evaluation of total sperm count (TSC), sperm motility (MOT), and sperm morphology (MOR) for Duroc boars. A total of 188,665 records derived from 3,684 …
  pubmed Lee H, Huang Y, Gu Y, Bussiman F 等 2026 Aug 22 置信度 0.82
• Association of Histopathologic Characteristics in Diagnostic Prostate Biopsies With Decipher Genomic Classifier Risk Groups.
  Prostate cancer remains the most frequently diagnosed malignancy in men. While traditional clinicopathologic parameters guide management, genomic classifiers such as the Decipher assay are increasingly used to refine risk stratification. In this study, we eval…
  pubmed Kurt S, Usman A, Torres E, Pease G 2026 Jul 置信度 0.82
• The Application Value of Liquid Biopsy in Cancer MRD Detection and the Preliminary Clinical Significance of the TFx Value.
  Plasma cell-free DNA (cfDNA)-based chromosomal instability (CIN) profiling is a non-invasive approach for tumor burden monitoring and treatment response assessment. This pilot study included 50 cancer patients (breast, oral, gastric, lung, and other cancers) t…
  pubmed Ding Y, Zhou W, Yao J, Yi J 等 2026 置信度 0.82
• Variant Harmonization Critically Determines Polygenic Score Transferability for Lipid Traits in Samoan Populations.
  Dyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. Polygenic scores (PGS) for lipid traits offer promise for improved CVD risk prediction; however, their performance in Pacific Islander populations …
  pubmed Yapp TJ, Krishnan M, Liu S, Manna SL 等 2026 Aug 22 置信度 0.82
• Rare Autosomal Trisomies Detected by Noninvasive Prenatal Testing: Performance, Outcomes, and Exploratory Analysis of the Theoretical Mosaicism Ratio.
  To characterize rare autosomal trisomies (RATs) detected by genome-wide noninvasive prenatal testing (GW-NIPT), evaluate their clinical significance, and explore whether sequencing-derived parameters are associated with adverse pregnancy outcomes.
  pubmed Liu Y, Wang J, Wang G, Dong H 等 2026 Aug 22 置信度 0.82
• Clinical outcomes and genomic landscape of anti-HER2 antibody-drug conjugates in HER2-positive and HER2-low metastatic breast cancer.
  Anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates (ADCs) have revolutionized the treatment for HER2-positive and HER2-low metastatic breast cancer (MBC). However, the comparative efficacy, safety, and molecular predictors of respons…
  pubmed Gui X, Chen H, Zhao J, Lai H 等 2026 置信度 0.82
• Caveolin-1 levels associated with coronary artery disease in Chinese participants: a retrospective cohort study.
  Coronary artery disease (CAD) remains a leading cause of mortality globally, yet approximately 30% of CAD risk remains unexplained by conventional factors. Caveolin-1 (Cav-1) regulates endothelial function through inhibiting endothelial nitric oxide synthase a…
  pubmed Chen J, Li H, Liang Y, Wang X 等 2026 置信度 0.82
• Prevalence and clinical impact of PIK3CA and PTEN alterations from reflex genomic testing of newly diagnosed colorectal cancer: a population-based series.
  Results from the Adjuvant Low dose Aspirin in Colorectal Cancer (ALASCCA) clinical trial demonstrate a survival benefit associated with aspirin use in patients with non-metastatic colorectal cancer (CRC) harbouring phosphoinositide 3-kinase (PI3K) pathway alte…
  pubmed Kerrin L, Al Haddad O, Reid E, O'Neill JJ 等 2026 置信度 0.82
• Whole-genome analysis and phenotypic antimicrobial resistance of Staphylococcus aureus isolated from foods in Northern Kazakhstan.
  Staphylococcal food poisoning is widespread, causing significant public health problems. This study aimed to characterize the genomic profiles and antimicrobial susceptibility of Staphylococcus aureus isolates obtained from food products in Northern Kazakhstan…
  pubmed Kozhakhmetova SS, Zholdybayeva EV, Basharova DA, Bekbayeva A 等 2026 置信度 0.82
• Structure-Guided Extremophile Genome Mining Expands the PETase Landscape and Reveals PET-Hydrolysing True Lipase Lineages.
  Poly(ethylene terephthalate) (PET) hydrolases are enzymes primarily within the polyesterase-cutinase branch of the &#x3b1;/&#x3b2;-hydrolase superfamily, whereas the contribution of true lipases to PET hydrolysis remains poorly explored. Here, we report the ge…
  pubmed Muñoz-Tafalla R, González-Romero JM, Vidal P, Fernandez-Lopez L 等 2026 Aug 置信度 0.82
• Prenatal Referrals for Differences of Sex Development: Genetic Diagnoses and Clinical Outcomes at a Tertiary Fetal Care Center.
  The objective of this study was to characterize prenatal referrals for differences of sex development (DSD) and associated genetic diagnoses and clinical outcomes at a tertiary fetal care center. We conducted a retrospective review of prenatal referrals to our…
  pubmed Haizler-Cohen L, Legro NR, Eckert A, Duncan SA 等 2026 Aug 21 置信度 0.82
• Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study.
  Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision-making, real-practice data on the prevalence and prognostic significance of genomic alterations…
  pubmed Arnouts J, van Kempen LC, Koljenović S, Oliveres H 等 2026 Aug 21 置信度 0.82
• Mendelian randomization and drug repurposing analysis identifies APOE as a potential therapeutic target for low back pain.
  Low back pain (LBP) is a prevalent chronic pain syndrome primarily driven by spinal degeneration, causing persistent disability and reduced quality of life. Despite available interventions, identifying novel therapeutic targets remains imperative for modifying…
  pubmed Yang J, Qi W, Wang D, Mei Z 等 2026 Aug 21 置信度 0.82
• MCM3 Safeguards Neural Progenitor Maintenance and Cortical Development Against Replication-Associated Stress.
  Faithful genome duplication during neurogenesis relies on the licensing of surplus replication origins, and hypomorphic variants in MCM3 have been associated with microcephaly and related growth disorders. Using in utero electroporation in embryonic mouse cort…
  pubmed Xu Z, Chen J, He S, Gao Y 等 2026 Aug 21 置信度 0.82
• Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1.
  Although chemotherapy in colorectal cancer (CRC) primarily targets epithelial tumor cells, the epithelial cell-intrinsic mechanisms underlying heterogeneous treatment responses remain poorly understood. We integrated the genomic, transcriptomic, and in vitro d…
  pubmed Erkan EP, Hämäläinen E, Kolikova J, Nikupaavola T 等 2026 Aug 21 置信度 0.82
• Genomic and epidemiological evidence linking a pre-season dengue case to local overwintering transmission in Guangdong, China.
  In March 2025, Guangdong Province reported China's earliest locally acquired dengue case, occurring two months before the typical transmission season. This unprecedented event raised critical questions about potential overwintering transmission mechanisms in s…
  pubmed Lin L, Liu M, Chen J, Guan Q 等 2026 Aug 置信度 0.82
• CircRNA profiles from one-tube multiplex probe-based qPCR can distinguish between monozygotic twins.
  Monozygotic twins (MZTs) pose a considerable challenge in personal identification due to their nearly identical genomic DNA sequences. Emerging evidence suggests that epigenetic markers, particularly non-coding RNAs (ncRNAs), may provide a promising strategy t…
  pubmed Tian M, Li Y, Wang YL, Wang SW 等 2026 Aug 21 置信度 0.82
• Exploring the impacts of type 2 diabetes and metformin use on Parkinson's disease: Mendelian randomization analysis and a national cohort study.
  The contribution of type 2 diabetes (T2D) and metformin use to Parkinson's disease (PD) remains unclear. This study aimed to investigate both the overall and independent effects of T2D and metformin use on PD risk.
  pubmed Fu L, Cao H, Baranova A, Zhang F 2026 Aug 21 置信度 0.82
• Genomic landscape of ERCC alterations in breast and gynecological cancers: implications for targeted therapy and VUS reclassification.
  The Excision Repair Cross-Complementation (ERCC) gene family is critical for the Nucleotide Excision Repair (NER) pathway, yet its clinical utility in solid tumors remains underexplored. Impaired DNA repair via ERCC alterations drives tumorigenesis and influen…
  pubmed Canbek S, Karaağaç M, Ermiş A, Türkan Ş 等 2026 Aug 21 置信度 0.82
• Origin, evolution and transmission dynamics of Orthobunyavirus Oropoucheense.
  Oropouche virus (OROV) is a high-risk emerging arbovirus that causes recurrent febrile outbreaks across tropical Central and South America, posing persistent public health threats with expanding endemic ranges and rising zoonotic spillover risks. Limited compr…
  pubmed Wang Z, Pang Y, Zhou X, Li Y 2026 Aug 21 置信度 0.82
• Evaluation of carbapenem inactivation method-based phenotypic assays for the detection of GES-type carbapenemases in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii.
  Detection of GES-type carbapenemases remains challenging because of their low prevalence and frequently weak hydrolytic activity against carbapenems. Carbapenem inactivation method (CIM)-based assays are widely used as phenotypic screening tools for carbapenem…
  pubmed García-García S, Rodríguez-Grande J, Siller-Ruíz M, Arjona-Torres C 等 2026 Aug 21 置信度 0.82
• Renin-Angiotensin System Inhibitor Use and Mortality in Older Hypertensive Patients With and Without Dementia: A Nationwide Registry-Based Cohort Study.
  Cardiovascular risk factors are often undertreated in patients with dementia. Renin-angiotensin system inhibitors (RASI) are first-line treatments for hypertension. We examined the association between RASI and all-cause mortality in hypertensive patients with …
  pubmed Villa Lopez M, Hoang MT, Xu H, Norgren J 等 2026 Aug 置信度 0.82
• Timing of Malignant Transformation in Recurrent Versus Nonrecurrent Oral Potentially Malignant Disorders: A Retrospective Study.
  Postoperative recurrence of oral potentially malignant disorders (OPMDs) is common. This study investigated whether the timing of malignant transformation differs between recurrent and nonrecurrent lesions.
  pubmed Yang SW, Lee YC, Lee YS 2026 Aug 20 置信度 0.82
• Genetic contributions to familial Ménière's disease: a systematic review.
  Meniere's disease (MD) is a fluctuating vestibulocochlear disorder with an unknown cause. Familial clustering occurs in 8-10% of cases, suggesting a genetic contribution, but the underlying mechanisms remain unclear. This systematic review synthesizes all sequ…
  pubmed Djian C, Jonard L, Marlin S 2026 Aug 20 置信度 0.82
• Molecularepidemiology and antimicrobial resistance determinants of Corynebacterium diphtheriae causing infections in Karachi, Pakistan, 2023-2024.
  Diphtheria remains endemic in Pakistan with cases increasing following the COVID-19 pandemic despite on-going vaccination programs. This study analyzes the genomic diversity, virulence and antimicrobial resistance patterns of pharyngeal diphtheria strains coll…
  pubmed Khan SMA, Irfan S, Ashraf J, Ghayas H 等 2026 Aug 20 置信度 0.82
• Perspectives of Clinical Genetics in Wisconsin: A Qualitative Analysis to Enhance Awareness About the Specialty and Guide Improvement.
  Genomic advances have launched medicine into a new frontier of preventive and personalized care, driving increased demand for services amid a recognized provider shortage. We aimed to highlight perspectives of clinical geneticists to support growth and sustain…
  pubmed Sorci IA, Siewert NJ, Petty EM 2026 置信度 0.82
• First molecular detection and partial ORF1 characterization of psittacine beak and feather disease virus (PBFDV) in domesticated parrots of Northern Vietnam.
  Psittacine beak and feather disease virus (PBFDV), currently classified within the species Circovirus parrot, is an infectious agent in avian species, particularly psittacine birds. PBFDV is the causative agent of psittacine beak and feather disease (PBFD), le…
  pubmed Minh H, Villanueva BHA, Dam QK, Huong LTL 等 2026 Aug 20 置信度 0.82
• Targeting epigenetic regulators induces transcription-replication conflicts to overcome ATR inhibitor resistance.
  Many cancer cells exhibit elevated replication stress and are highly dependent on ataxia telangiectasia and Rad3-related (ATR) kinase activity to maintain genomic stability and survival. While ATR inhibitors (ATRi) have great promise as therapeutic agents, int…
  pubmed Awwad SW, Barber H, Coulthard J, Lam S 等 2026 Aug 10 置信度 0.82
• Genetic diversity and clinical spectrum of Mycobacterium abscessus complex in India.
  The Mycobacterium abscessus complex is a rapidly growing nontuberculous mycobacterium that causes chronic lung, skin, and soft-tissue infections. Disease management is challenging because of prolonged antibiotic therapy and resistance, making knowledge of loca…
  pubmed Balaji V, Ninan MM, Chase S, Gupta R 等 2026 Sep 置信度 0.82
• Meningococcal carriage in UK university students post-pandemic: evidence for MenACWY vaccine impact and ongoing genogroup B risk.
  Neisseria meningitidis is a commensal bacterium that asymptomatically colonizes the nasopharynx but can cause invasive meningococcal disease (IMD). Carriage studies are essential to complement disease surveillance and for evaluating the impact of vaccination p…
  pubmed Harvey-Cowlishaw T, Wartnaby S, Trujillo-Mendoza J, Clark JL 等 2026 置信度 0.82
• Household Transmission of Human Metapneumovirus and Human Parainfluenza Viruses 1-4 in the United States, 2022-2024.
  Human metapneumovirus (HMPV) and human parainfluenza viruses (HPIV 1-4) are common causes of seasonal respiratory illness, but their household transmission dynamics remain poorly defined. We analyzed weekly symptom data and nasal swabs from a prospective house…
  pubmed Roychoudhury P, Elias-Warren A, Wetzler E, Kim HG 等 2026 Aug 3 置信度 0.82
• Biallelic loss of RB1 in hepatocellular carcinoma as synthetic lethal target for artificial intelligence-guided therapy.
  The retinoblastoma (RB1) gene is a critical tumor suppressor that regulates cell cycle progression and genomic stability. Although RB1 alterations have been reported in hepatocellular carcinoma (HCC), the biological and clinical consequences of biallelic RB1 i…
  pubmed An J, Kim W, Zhang X, Chikontwe P 等 2026 Aug 20 置信度 0.82
• [Molecular epidemiological study of 72 human-derived aeromonas in Guangdong Province, 2019-2024].
  Objective: To investigate the drug resistance profiles and molecular epidemiological characteristics of Aeromonas species isolated from human clinical samples. Methods: A total of 72 Aeromonas isolates were collected and identified to the species level using b…
  pubmed Li T, Huang YN, He DM, Liu JJ 等 2026 Aug 10 置信度 0.82
• Editorial Board
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• Editorial Board
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• Editorial Board
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• Editorial Board
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• Editorial Board
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• Editorial Board
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• Editorial Board
  crossref 2024-05-10T11:10:17Z 置信度 0.70
• <i>Forensic Genomics</i> : 2024 in Review
  crossref Nicole M. Novroski 2024-12-17T15:54:06Z 置信度 0.70
• Population Genomics: Crop Plants
  crossref 2024-06-08T15:02:01Z 置信度 0.70
• David C. Page
  crossref David C. Page 2024-01-10T10:39:39Z 置信度 0.70
• Genomics
  crossref Lori A.S. Snyder 2024-03-05T15:01:45Z 置信度 0.70
• Genomics in the Clinic
  crossref 2024-01-21T08:57:17Z 置信度 0.70
• Viral genomics
  crossref Sara H. Mahmoud, Ahmed A. Khalil 2024-08-02T04:13:30Z 置信度 0.70
• Introduction to genomics-based industrial applications
  crossref Imane Boudellioua 2024-08-02T04:13:08Z 置信度 0.70
• Communicating Genetics and Genomics
  crossref Isha Gupta, Antonie D. Kline, Ethylin Wang Jabs 2024-01-21T10:10:37Z 置信度 0.70
• Erratum
  crossref 2024-08-27T04:28:02Z 置信度 0.70
• Microfluidics in Genomics
  crossref Shabroz Alam, Juveriya Israr, Ajay Kumar 2024-07-31T01:01:40Z 置信度 0.70
• Meet the author: Jayne Hehir-Kwa
  crossref Jayne Hehir-Kwa 2024-11-13T16:33:18Z 置信度 0.70
• Advancing equity in human genomics through tissue-specific multi-ancestry molecular data
  crossref Ana Luiza Arruda, Andrew P. Morris, Eleftheria Zeggini 2024-01-24T10:37:45Z 置信度 0.70
• Acknowledgment of Reviewers 2023
  crossref 2024-03-14T15:58:18Z 置信度 0.70
• Acknowledgement to Reviewers of Human Population Genetics and Genomics in 2024
  crossref 2024-12-23T06:08:18Z 置信度 0.70