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• Adaptive evolution of polyploid crops.
  Crop evolution represents a fundamental biological process through which plants respond to selection in different environments. This encompasses mechanisms operating at multiple scales of biological organization, including genetic and epigenetic regulation and…
  pubmed Wang P, Li C, Wang D, Sun T 等 2026 Aug 19 置信度 0.82
• Exploring the landscape of targetable alterations in patients with glioblastoma.
  Glioblastomas remain the most lethal primary brain tumour in adults, with targeted therapies delivering only limited benefit despite deep molecular characterization. Several targeted drugs have received regulatory approval for low-grade gliomas, although progr…
  pubmed Aquilanti E, Touat M, French P, Iavarone A 等 2026 Aug 19 置信度 0.82
• Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer.
  Liver cancer remains a major global challenge, with limited benefit from immune checkpoint inhibitors due to strong immune evasion. Emerging evidence indicates that chromatin modifiers shape tumor immunogenicity, but their roles in liver cancer immunity are no…
  pubmed Gragnani L, Lulli M, Caini P, Faviana P 等 2026 Aug 19 置信度 0.82
• Fetal Compound Heterozygous Microdeletion at 7q31.1 Involving IMMP2L: Case Report and Literature Review.
  Copy number variations (CNVs) represent a significant genetic etiology for birth defects. Reports on microdeletions involving the 7q31.1 region remain scarce in the literature, with existing studies primarily documenting heterozygous deletions. Compound hetero…
  pubmed Chen C, Song Q, Jiang X, Tang T 等 2026 Aug 置信度 0.82
• How multi-omic technologies can help define paediatric undifferentiated systemic autoinflammatory diseases: the experience of the European PerSAIDs consortium.
  Systemic AutoInflammatory Diseases (SAIDs) are rare conditions characterised by impaired control of inflammatory and innate immune responses. Precision medicine is already well established for monogenic SAIDs, while personalised approaches remain elusive for t…
  pubmed Speziani C, Palmeri S, Uva P, Gattulli S 等 2026 Aug 19 置信度 0.82
• Glycyl radical enzymes and their impact on microbial physiology.
  Glycyl radical enzymes (GRE) use radical-based biochemistry to catalyze the cleavage or formation of the carbon-carbon and carbon-heteroatom bonds found in organic molecules. These evolutionarily ancient enzymes are highly oxygen-sensitive but widespread in ob…
  pubmed Sawers RG, Erdmann C, Hardelt M 2026 置信度 0.82
• Artificial intelligence agents and agentic artificial intelligence applied to precision medicine.
  Precision medicine seeks to individualise care by integrating multimodal biomedical data, yet most deployed clinical artificial intelligence (AI) remains assistive, providing predictions without managing workflows or adapting autonomously. Agentic AI, built on…
  pubmed Costa FF 2026 Aug 19 置信度 0.82
• Unmet needs in SLC29A3-related disorders.
  SLC29A3-related disorders are autosomal recessive conditions characterized by histiocytic infiltration, autoinflammatory and autoimmune manifestations, and variable degrees of immune deficiency. SLC29A3-related disorders are rare and complex, with a broad spec…
  pubmed Jouret M, Tise CG, Mathieu AL, Gomez-Ospina N 等 2026 Aug 19 置信度 0.82
• Secondary metabolism in fungal-insect interactions: Short Title: Metabolites in insect symbioses.
  Natural products are central to the ecology and evolution of many insect-microbe symbioses, where they underpin parasitism, host manipulation, and cooperative interactions. In this review, we examine recent discoveries of secondary metabolites produced by fung…
  pubmed Shin S, Berasategui A 2026 Aug 19 置信度 0.82
• Precision Medicine in Combating Antimicrobial Resistance: A Comprehensive Review.
  Antimicrobial resistance (AMR) represents one of the most pressing threats to global public health, undermining the effectiveness of modern antimicrobial therapy and challenging decades of medical progress. This comprehensive review examines the transition fro…
  pubmed Jallow L, Hodosika H, Bajinka O 2026 Aug 19 置信度 0.82
• The regulatory role of non-coding RNAs in taxane resistance of breast cancer.
  Breast cancer remains a major health concern among women, characterized by a high risk and substantial mortality. Chemotherapy is widely employed as a standard treatment modality to eliminate malignant cells and improve patient survival. Nevertheless, recurren…
  pubmed Sun C, Lv L, Xu Q, Wu S 等 2026 Aug 19 置信度 0.82
• Patient-derived models of prostate cancer: Capturing tumour complexity from initiation to metastasis.
  Prostate cancer is a growing global health challenge. To identify new ways to improve patient care, researchers need a variety of preclinical models that faithfully recapitulate human tumours across the disease continuum, from initiation to metastasis. These c…
  pubmed Le Magnen C, Brennen WN, Aytes Á, Bock N 等 2026 Aug 19 置信度 0.82
• Leveraging plant virus-vector molecular interactions for innovative vector and disease control.
  Although insect-transmitted plant viruses cause substantial global crop losses, knowledge of the molecular mechanisms underlying their transmission is limited. Recent advances in omics technologies, high-resolution tissue-specific profiling, and protein-protei…
  pubmed Bonning BC 2026 Aug 19 置信度 0.82
• Baseline frequency of micronuclei and other nuclear abnormalities in pregnant women: A scoping review and meta-analysis.
  Baseline frequency of micronuclei and other nuclear abnormalities in pregnant women: a scoping review and meta-analysis Pregnancy involves physiological and metabolic changes that may influence genomic stability and increase the occurrence of nuclear abnormali…
  pubmed Araújo AC, Freire MCDS, Marques JCMT, Rodrigues KDDSR 等 2026 Aug 19 置信度 0.82
• Personalizing endometrial cancer care beyond histology: clinical applications and limits of molecular classification.
  Endometrial cancer is a biologically heterogeneous disease whose management has been reshaped by molecular classification. This review summarizes the current evidence supporting the integration of molecular subgroups into prognostic assessment and treatment pe…
  pubmed Marchetti M, Panizzolo E, Caruso G, Delfrati S 等 2026 Jul 30 置信度 0.82
• Purifying a corrosive hydrocarbon-degrading Shewanella indica from iron rust in oil-containing seawater: Understanding of microbial corrosion mechanisms based on whole genome analysis.
  Corrosion products covering corroded steels immersed in oil-contaminated seawater for 465 days were analyzed for genomic, microbial activity, mineral, and morphology. Compared to 85 days of immersion, abundant chemolithotrophic bacteria predominantly…
  pubmed Guo D, Zhang Y, Zhai X, Duan J 2026 Aug 19 置信度 0.82
• Foundation models in omics research: a comprehensive survey.
  The rapid expansion of high-throughput omics has created molecular datasets of unprecedented scale and complexity. These data are rich in biological information yet inherently sparse and high-dimensional, often limiting the effectiveness of conventional machin…
  pubmed Liu H, Cai W, Sun Y, Liu H 等 2026 Jul 3 置信度 0.82
• The role of mitochondrial dysfunction and genetics in female infertility and premature ovarian insufficiency.
  Female infertility occurs in ∼37% of infertile couples, while premature ovarian insufficiency (POI) impacts 1-3.7% of women under the age of 40. POI is clinically heterogeneous, with various genetic pathways associated with its pathogenesis. Mitochondri…
  pubmed Kline BL, Compton AG, Frazier AE, Pachernegg S 等 2026 Aug 19 置信度 0.82
• The Continuity Trap in Data Science Health Research.
  Secondary use is now the ordinary condition of data science health research rather than an exception to it. Electronic health records collected for clinical care become prediction tools and inputs for generative AI; imaging archives become foundation-model cor…
  pubmed Adebamowo C, Adebamowo SN, Akintola A, Ikhane P 等 2026 Aug 19 置信度 0.82
• Trace Element Dyshomeostasis as a Mediator of Toxic Metal-Induced Reproductive Dysfunction: Mechanistic Insights and Future Perspectives.
  Exposure to toxic metals has become a major environmental and public health concern due to its adverse effects on reproductive health. Recent evidence indicates that, beyond their direct toxicity, toxic metals can disrupt the homeostasis of essential trace ele…
  pubmed P MK, Mayakrishnan G, R P, R B 2026 Aug 19 置信度 0.82
• The Real Life of Ataxia Patients Without a Vertical Family History: a Twenty-year Experience in South Brazil.
  Studies of hereditary ataxias (HA) without vertical family history are necessary for designing diagnostic protocols. We described the 20 years' experience of a Brazilian reference service with these cases through a retrospective cohort study of subjects e…
  pubmed Aschoff CAM, Silva TO, Hasan A, Migliorini E 等 2026 Aug 19 置信度 0.82
• Establishment and functional characterization of an EGFR-amplified tumoroid from squamous cell carcinoma of unknown primary.
  Carcinoma of unknown primary (CUP) remains a clinically challenging malignancy with limited treatment options and poor prognosis. Although genomic profiling has identified potentially actionable alterations, optimal therapeutic strategies are often unclear. He…
  pubmed Iwai M, Yokota E, Yukawa T, Matsumoto K 等 2026 Aug 19 置信度 0.82
• Empowering Plant Biotechnology Research: Super-Pangenomes as a Novel Arsenal for Crop Breeding and Improvement.
  The continuous innovations in sequencing methods have revolutionized the plant genomics research by capturing species diversity. Pangenome incorporates data from multiple genomes to generate a comprehensive and reference bias genomic architecture within a popu…
  pubmed Sena S, Kumar V 2026 Aug 19 置信度 0.82
• [Aldosterone: mechanisms of normal and impaired regulation and the possibility of their correction in arterial hypertension. Consensus of Russian Medical Society on Arterial Hypertension (RSH) experts].
  In recent years, studies have been carried out that have expanded the understanding of the role of pathophysiological mechanisms underlying impaired regulation of aldosterone and activation of mineralocorticoid receptors in arterial hypertension. The aim of th…
  pubmed Chikhladze NM, Blinova NV, Trushina OI, Podzolkov VI 等 2026 Jul 31 置信度 0.82
• Standardized Xenograft Models for Preclinical Cancer Research.
  Xenograft models are the principal in vivo platform of preclinical oncology and the most established experimental link between cell culture and clinical investigation. From the carcinogen-exposed rabbit models of the early twentieth century through the current…
  pubmed Ovcharenko D 2026 Aug 18 置信度 0.82
• Autophagy and mitophagy in pancreatic β-cell homeostasis and their involvement in diabetes pathophysiology.
  Autophagy is an evolutionarily conserved cellular quality control pathway that responds to the metabolic state of the cell, and its dysregulation has been broadly associated with metabolic disorders like diabetes mellitus. Among different types of autophagy, m…
  pubmed Lee Y, Tong M, Gloyn AL 2026 Aug 19 置信度 0.82
• The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity.
  Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network-level mechanisms. Advances in genomic technologies have rev…
  pubmed Seyedtaghia MR, Babanzadeh J, Scala M, Perilli L 等 2026 Aug 19 置信度 0.82
• RFWD3: A pivotal E3 ubiquitin ligase in DNA damage response, non-neoplastic disorders and multi-system tumorigenesis.
  RFWD3 is a multifunctional RING-type E3 ubiquitin ligase and a central hub in the DNA damage response (DDR) network. It regulates replication fork stability, homologous recombination repair, and cell cycle checkpoints through K63-linked ubiquitination of criti…
  pubmed Ding Y, Zhu M, Shu J, Zhou G 等 2026 Jul-Sep 置信度 0.82
• Current Status of Genetic Testing and Mosaic Variant Assessment in Somatic Overgrowth and Vascular Anomalies: Insights from the Cancer Genomics Consortium Working Group.
  Somatic overgrowth and vascular anomalies are often present at birth but may only be clinically recognized later in life. Affected tissues commonly include veins and arteries, skin, adipose tissue, bone, and brain, resulting in a broad phenotypic spectrum enco…
  pubmed Dharmadhikari AV, Myers CT, King KA, Mojarad B 等 2026 Aug 19 置信度 0.82
• High-resolution profiling of bacterial transcriptomes by SEnd-seq.
  Transcription-the process by which genomic DNA is converted into RNA-is a highly dynamic and tightly controlled process across all domains of life. Although bacteria were once regarded as relatively simple organisms, their transcriptomes are now recognized to …
  pubmed Ju X, Liu S 2026 Sep 2 置信度 0.82
• SRF fusion genes in myoid soft tissue tumors.
  Serum response factor (SRF) is a ubiquitously expressed transcription factor that regulates immediate early genes, cytoskeletal organization, and muscle differentiation. Although SRF plays critical roles in development and cell growth, genomic alterations of S…
  pubmed Sablon A, Pirson C, Antonescu CR, Demoulin JB 2026 Aug 19 置信度 0.82
• p53 Pathway-Targeted Therapeutic Strategies in Glioblastoma: A CNS-Specific Framework Integrating Therapeutic Resistance, Molecular Stratification, CNS Pharmacology, and Clinical Translation.
  Glioblastoma (GBM) remains one of the most difficult therapeutic problems in adult neuro-oncology. Its resistance to treatment reflects not only malignant cellular biology but also central nervous system-specific constraints, including blood-brain barrier and …
  pubmed Bu F, Zeng S, Ma C, Zhang M 2026 置信度 0.82
• QTL rich genomic clusters in wheat: a catalogue for resistance to Puccinia striiformis f. sp. tritici.
  Wheat stripe/yellow rust, caused by Puccinia striiformis f. sp. tritici (Pst), remains one of the most significant constraints to global wheat production. Genetic resistance breeding is the most effective, economical, and environmentally sustainable strategy f…
  pubmed Micheni C, Singh D, Park RF, Ziems L 2026 置信度 0.82
• Epitranscriptomics, immunometabolism, and NETosis: unlocking novel mechanisms of traditional Chinese medicine in COPD.
  Chronic obstructive pulmonary disease (COPD) is driven by self-perpetuating inflammation that resists conventional therapies. Recent evidence reveals three interconnected pathogenic layers: immunometabolic reprogramming, m 6 A epitranscriptomic dysregulation, …
  pubmed Chen HH, Ni FX, Huang DH, Jiang ZB 2026 置信度 0.82
• A machine learning framework for predictive interpretation of variants of uncertain significance in hereditary cancer.
  Variant interpretation remains a major bottleneck in clinical genomics, with variants of uncertain significance (VUS) representing a critical unresolved challenge due to insufficient evidence for definitive classification. Existing in silico tools exhibit vari…
  pubmed Nizamuddin N, Biswas S, Zawar A, Deshpande P 等 2026 置信度 0.82
• Nutrition in Pediatric Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
  Lifestyle change, including weight loss in children with overweight and obesity, through intensive health behavior and lifestyle treatment (IHBLT) is one of the main pillars in the management of pediatric metabolic dysfunction-associated steatotic liver diseas…
  pubmed Nonga D, Gisser J, Chaves E, DiPangrazio A 等 2026 置信度 0.82
• Optimizing phenotypic data analysis strategies to enhance genomic prediction in winter wheat breeding.
  Proper analysis of phenotypic data is essential for reliable genomic prediction (GP) and sustained genetic gain in breeding programs. In this study, we used phenotypic and genotypic data generated from the winter wheat breeding program of Deutsche Saatveredelu…
  pubmed Gundala RR, Witte G, Doernte J, Koch M 等 2026 置信度 0.82
• Macrophage-associated noncoding RNAs in atherosclerosis and chronic kidney disease.
  Although approximately 97% of the human genome does not encode proteins, it produces a vast repertoire of regulatory RNA transcripts that play critical roles in cellular and molecular processes. Among these, noncoding RNAs including microRNAs and long noncodin…
  pubmed Jha PK, Nascimento CB, Lupieri A, Aikawa E 等 2026 置信度 0.82
• Optimizing resource allocation in Miscanthus breeding via sparse testing designs for genomic prediction.
  Phenotyping high-biomass perennial crops is laborious and the rate of genetic gain in conventional perennial crop breeding programs is typically low. So, it is especially important to identify methods that produce efficiency gains in the breeding process. Misc…
  pubmed Proma S, Lubanga N, Sacks E, Leakey ADB 等 2026 置信度 0.82
• Mouse models of B cell lymphomas on the basis of genetic features.
  Diffuse large B cell lymphoma (DLBCL) is a highly aggressive form of lymphoma that is genetically and phenotypically diverse. Most DLBCLs arise from the germinal center and transcriptionally represent either germinal center or post-germinal center activated B …
  pubmed Yuan M, Wang JQ 2026 置信度 0.82
• Chicken heterophils as evolutionary models: insights into myeloperoxidase-independent antimicrobial strategies.
  The study of granulocytic phagocytes has been dominated by mammalian neutrophils, creating significant knowledge gaps in understanding functionally analogous granulocytes (heterophils) across vertebrate evolution. This review systematically examines chicken he…
  pubmed Woo SJ, Songodan T, Seo M, Han JY 2026 置信度 0.82
• A translational framework for early-phase inner-ear gene therapy: clinical trial design, regulatory strategy, and ethical considerations.
  Hereditary hearing loss has historically been approached as a diagnostic category rather than a therapeutically modifiable disease. Recent advances in molecular genetics, cochlear gene delivery, and first-in-human clinical trials are changing that. This review…
  pubmed Dunn EC, Short SH, Samy RN 2026 Aug 19 置信度 0.82
• Multi-Omics-Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation.
  Nucleic Acid Therapeutics (NATs), including Antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and messenger RNAs (mRNAs), are a rapidly developing class of therapeutics capable of specifically regulating previously considered undruggable and …
  pubmed Bhatti GK, Verma A, Devi K, Khullar N 等 2026 Aug 置信度 0.82
• Artificial Intelligence in Post-translational Modification Site Prediction: Progress and Future Perspectives.
  Post-translational modifications (PTMs) are pivotal in modulating protein function and cellular processes. However, experimental identification of PTM sites remains costly and labor-intensive. Recent advances in artificial intelligence (AI) have enabled accura…
  pubmed Ran J, Zhang X, Wang Y, Chen S 等 2026 Aug 18 置信度 0.82
• Stem cell-based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons.
  Pediatric disorders consist of genetic, hematologic, neurologic, autoimmune, and inflammatory diseases. These conditions impose long-term health challenges on children, despite many advancements with conventional medicine. Although conventional treatments incr…
  pubmed Marei HE 2026 Aug 15 置信度 0.82
• LC-MS-Based Analytical Strategies for Ganglioside Profiling.
  Gangliosides, a class of glycosphingolipids containing sialic acid residues, are abundantly expressed in neuronal membranes and play essential roles in cellular signaling and intercellular communication. Impaired ganglioside metabolism contributes to the patho…
  pubmed Ikeda K 2026 置信度 0.82
• Paediatric therapeutic development workshop on osteosarcoma.
  The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement ov…
  pubmed Baxter JS, Montiel Equihua C, Molenaar JJ, Berlanga P 等 2026 Aug 18 置信度 0.82
• Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study.
  Increased childhood adiposity contributes to higher type 2 diabetes (T2D) risk, but the underlying mechanisms remain unclear. Furthermore, whether these mechanistic pathways are shared across ethnic groups has not been explored.
  pubmed Chen S, Liang Y, Luo S, Zheng J 等 2026 Aug 18 置信度 0.82
• Interplay Between Base Editing and DNA repair: From Molecular Mechanisms to Clinical Translation.
  Base editors (BEs) are transformative genome engineering tools that enable precise nucleotide substitutions without inducing double-strand breaks (DSBs) or requiring donor DNA templates. Since the first cytosine base editor (CBE) was developed in 2016, the fie…
  pubmed Tao R, Li M, Luo T, Yao S 2026 Aug 18 置信度 0.82
• Precision medicine breakthrough: Multi-omics integration elevates CAD risk prediction.
  Coronary artery disease (CAD) remains the leading cause of global mortality. Multi-omics integration offers unprecedented opportunities for precision risk stratification beyond conventional approaches. However, comprehensive integration of genomic, proteomic, …
  pubmed Su Q, Li QY, Hu CK, Huang Y 等 2026 Aug 18 置信度 0.82
• Global, regional, and national burden of HIV/AIDS, 1990-2023, with the estimated burden attributable to intimate partner violence and forecasted impacts of funding cuts through 2030: results from the Global Burden of Disease Study 2023.
  Despite a general improvement in the HIV burden over the past two decades, gendered social determinants including intimate partner violence (IPV) continue to affect women's vulnerability to HIV, which could be further exacerbated as resources dwindle over the …
  pubmed GBD 2023 HIV Collaborators 2026 Aug 18 置信度 0.82
• Mapping subcellular microenvironments using oligonucleotide-directed proximity labeling.
  Understanding how cells compartmentalize their biomolecules into discrete structures remains one of the fundamental goals of cell biology. The proliferation of proximity labeling (PL) technologies has been invaluable toward this goal, enabling biochemical "dis…
  pubmed Schactler SA, Skiados NG, Gajendragadkar AA, DeLeon LE 等 2026 Aug 18 置信度 0.82
• A phase 2 study of encorafenib in combination with binimetinib for Chinese participants with BRAF(V600E) mutated metastatic non-small cell lung cancer: Results from the OCEAN II study.
  The ongoing OCEAN II study (ClinicalTrials.gov identifier: NCT05195632) evaluates encorafenib in combination with binimetinib (E+B) in Chinese participants with BRAF V600E -mutated metastatic non-small cell lung cancer (NSCLC).
  pubmed Zhou H, Zhou Q, Guo Q, Guo W 等 2026 Aug 13 置信度 0.82
• Learning from facultative CAM plant Mesembryanthemum Crystallinum: Molecular mechanisms for climate-smart agriculture.
  Global population growth and frequent episodes of drought pose significant challenges to agricultural sustainability, necessitating the development of crops with enhanced stress adaptability and water-use efficiency (WUE). Crassulacean acid metabolism (CAM) is…
  pubmed Tan B, Chen S 2026 Aug 11 置信度 0.82
• Molecular Prenatal Diagnosis of Monogenic Diseases, Towards Non-invasive Procedures.
  In this narrative review, we outline the historical progression of, and modern advancements in, prenatal diagnosis for monogenic diseases. Initially dependent on invasive sampling procedures, prenatal diagnosis has evolved through the integration of high-throu…
  pubmed Verebi C, Nectoux J, Bienvenu T 2026 Aug 18 置信度 0.82
• Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment.
  Medicinal plants have served as the foundation of healthcare across cultures for centuries, yet their safety is increasingly undermined by heavy metal and pesticide contamination driven by industrial growth, agrochemical misuse and environmental degradation. D…
  pubmed Shukla P, Gupta P, Singh A, Singh N 等 2026 Aug 18 置信度 0.82
• Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas.
  Sellar region neurocytoma (SELN) is a rare neoplasm whose relationship to other neurocytomas within the central nervous system (CNS) has remained unclear. Prior reports have variably classified SELN as a variant of extraventricular neurocytoma (EVN), while imm…
  pubmed Pearce TM, Cimino PJ, Lucas CG, Marker DF 等 2026 Aug 18 置信度 0.82
• Clinical, microbiological, and molecular characteristics, outcomes, and risk factors for mortality of patients with Stenotrophomonas maltophilia bloodstream infection.
  The aim of this study was to explore the clinical, microbiological, and molecular characteristics of Stenotrophomonas maltophilia bacteraemia, outcomes, and risk factors associated with mortality.
  pubmed Ali GA, Al-Jabri MY, Goravey W, Shunnar KM 等 2026 Aug 18 置信度 0.82
• Cytotoxic immune activity reflects a coordinated immune microenvironment and is associated with response to total neoadjuvant therapy in rectal cancer.
  Total neoadjuvant therapy (TNT) has emerged as a promising treatment strategy for locally advanced rectal cancer; however, robust biomarkers predicting treatment response remain lacking. We aimed to identify pretreatment transcriptomic determinants of TNT resp…
  pubmed Haraguchi E, Tanaka N, Sato K, Noguchi T 等 2026 Aug 18 置信度 0.82
• Recent advances in the defense mechanisms of arbuscular mycorrhizal fungi in antibiotic-contaminated soil ecosystems.
  Arbuscular mycorrhizal fungi (AMF) are important soil symbionts that support plant nutrient acquisition, stress tolerance, and soil ecosystem stability. The increasing accumulation of antibiotic residues in agricultural soils may inhibit AMF spore germination,…
  pubmed Liu Y, Wang L, Cai B 2026 Aug 18 置信度 0.82
• Delineation of Paraburkholderia tuberum and description of Paraburkholderia lebeckiae sp. nov. isolated from the root nodules of South African Lebeckia ambigua.
  Paraburkholderia tuberum is a diverse beta-rhizobial species (i.e. rhizobia bacteria belonging to the class Betaproteobacteria ) indigenous to South Africa that associates mostly with indigenous papilionoid legume species. The taxonomic boundary of this specie…
  pubmed Mavima L, Steenkamp ET, Soogun TO, Beukes CW 等 2026 Aug 置信度 0.82
• Primary cell cultures versus immortalized cell lines: critical comparative insights into biological fidelity and translational applications.
  In vitro cell culture models are fundamental to biomedical research, yet the choice between primary cell cultures and immortalized cell lines profoundly influences experimental outcomes. Immortalized lines offer convenience and unlimited proliferative capacity…
  pubmed Suali L, Chia Y, Rustin C, Lem FF 等 2026 Aug 18 置信度 0.82
• AI-driven CRISPR strategies in breast cancer: Organoid modeling, adaptive editing, and precision delivery.
  Triple-negative breast cancer (TNBC) is defined by profound heterogeneity, dormant metastatic reservoirs, and rapid therapy resistance. Building on our AI-Driven CRISPR Strategies in Breast Cancer framework, CRISPR-Cas9 is emerging as more than a gene-editing …
  pubmed Taki AG, Shareef A, Arora V, Oweis R 等 2026 置信度 0.82
• Crop wild relatives of legumes: evolutionary resources for climate-responsive pre-breeding.
  Legume crops are increasingly exposed to a combination of abiotic stresses - including drought, heat, salinity and flooding - alongside mounting biotic pressures from pathogens and insect pests. Historical domestication and modern breeding practices have subst…
  pubmed Avasiloaiei DI, Calara M, Brezeanu PM, Burzo I 等 2026 置信度 0.82
• Circulating tumor DNA in colorectal cancer: assay selection, clinical applications, and practical integration for gastroenterologists.
  Circulating tumor DNA (ctDNA) has rapidly evolved from a research tool to a clinically applicable biomarker in colorectal cancer (CRC), transforming the assessment of minimal residual disease (MRD) and recurrence risk. The growing availability of commercial as…
  pubmed Sharma A, Tan JK, Kumar H, Dhali A 等 2026 置信度 0.82
• Sex differences in innate immune cell responses: Impact on cancer immunity and response to therapy.
  Sex hormones regulate innate and adaptive immune responses to infection, autoimmunity, and carcinogenesis through genomic and non-genomic mechanisms. Estrogen, progesterone, and androgen receptors are widely expressed on immune cells and modulate their functio…
  pubmed Ramin S, Medler TR 2026 置信度 0.82
• Targeting metabolic inflammation in type 2 diabetes mellitus through exercise: multi-level mechanisms of insulin resistance reversal and precision clinical translation - a review.
  Insulin resistance (IR) remains the central pathophysiological driver of type 2 diabetes mellitus (T2DM) and is inadequately targeted by current pharmacotherapies. Emerging evidence in immunometabolism identifies metabolic inflammation (meta-inflammation) as a…
  pubmed Wu L 2026 置信度 0.82
• TET2: a critical regulatory hub with broad therapeutic implications across human diseases.
  Ten-Eleven Translocation 2 (TET2) is a pivotal α-ketoglutarate and Fe 2+ -dependent dioxygenase belonging to the TET family, governing epigenetic homeostasis through DNA, RNA, and histone modifications. Its central function involves the iterative oxidati…
  pubmed Tang J, Wang R, Long L, Ma W 等 2026 置信度 0.82
• Cross-Cancer Detectability of ctDNA Biomarkers in Asian Populations: Implications for Pan-Cancer Detection.
  Cancer remains a leading cause of global mortality, making early detection essential for improvingpatient outcomes. Circulating tumor DNA (ctDNA) has emerged as a minimally invasive liquid biopsy approach for cancer detection and monitoring. Nevertheless, curr…
  pubmed Rarasati AR, Ramadhanti J, Ma'ruf IF, Rohmawaty E 等 2026 置信度 0.82
• Cyclins and Cyclin-Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer.
  Cyclins and cyclin-dependent kinases (CDKs) are frequently dysregulated in human cancers and represent compelling therapeutic targets. Beyond their well-recognized roles in cell cycle control, CDK/cyclin complexes orchestrate diverse oncogenic processes, inclu…
  pubmed Zheng S, Shen Z, Wu Y, Huang X 等 2026 Sep 置信度 0.82
• Advancing recombinant protein production in CHO cells through metabolic engineering.
  Chinese hamster ovary (CHO) cells serve as the predominant platform for producing recombinant therapeutic proteins in biopharmaceutical manufacturing, the production capacity of which relies heavily on efficient protein synthesis, folding, and secretion pathwa…
  pubmed Hou L, Li W, Li Z, Geng S 等 2026 置信度 0.82
• Positioning Guselkumab in The Treatment Algorithm for Ulcerative Colitis.
  Ulcerative colitis is a chronic inflammatory bowel disease requiring long-term therapeutic strategies that balance efficacy, safety and durability/ persistence. As treatment targets have evolved toward deep remission, including clinical, endoscopic and histolo…
  pubmed D'Amico F, Fanizzi F, Magro F, Dignass A 等 2026 置信度 0.82
• Exploring Genetic Therapies Targeting Amyotrophic Lateral Sclerosis in Animal Models: A Systematic Review and Meta-Analysis.
  Amyotrophic lateral sclerosis (ALS) is a rare, neurodegenerative disease, for which there is currently no known cure. ALS primarily affects motor neurons, with rapid deterioration, meaning symptoms develop quickly, from problems with speech and muscle weakness…
  pubmed Wedgwood HE, Tuxworth RI, Ahmed Z 2026 Aug 置信度 0.82
• Interleukin-23 Receptor and Interleukin-17 Receptor A: Splice Variants, Isoforms and Their Relationship With Periodontitis-A Systematic Review and Bioinformatic Analysis.
  This systematic review aimed to: (1) identify the splicing variants of IL23R and IL17RA reported in the literature; (2) perform a multiple alignment analysis to describe the isoforms of IL-23R and IL-17RA; and (3) compare the expression levels of IL-23R, IL-17…
  pubmed Alarcón-Sánchez MA, Guerrero-Velázquez C, Ortuño-Sahagún D, Lomelí-Martínez SM 等 2026 Aug 置信度 0.82
• The role of the food matrix in peptide bioavailability: a review of interactions and their impact on absorption.
  Bioactive peptides (BAPs) derived from food proteins exhibit a wide range of health-promoting activities, but their potent in vitro bioactivity is disconnected from their often-limited efficacy in vivo. This discrepancy is driven by aggressive gastrointestinal…
  pubmed Liu C, Wen C, Olatunji OJ, Ashaolu TJ 2026 Aug 17 置信度 0.82
• Evaluating Estimates of Recent Tuberculosis Transmission Using Epidemiologic and Whole-Genome Sequencing Data, Los Angeles County, California, 2014-2018.
  Estimating the percentage of tuberculosis cases in a population attributable to recent transmission, compared with reactivation of past infections, is crucial for public health decision-making. This study evaluated a previously published plausible-source case …
  pubmed McDaniel CJ, Talarico S, Raz KM, Kammerer S 等 2026 Aug 17 置信度 0.82
• Closing the Translational Gap: Closed-Loop AI Discovery Frameworks for Experimental Validation and Clinical Implementation in Cancer Therapeutics.
  The development of novel cancer therapeutics is a protracted, costly endeavor with high attrition rates, largely attributed to tumor heterogeneity and acquired resistance. Artificial intelligence (AI) is emerging as a powerful technology to enhance the drug di…
  pubmed Ören Varol T, Varol M 2026 Aug 置信度 0.82
• Using MetaboAnalyst 6.0 for exposomics data analysis-from LC-MS2 spectra processing to dose-response modeling and causal inference.
  Exposomics is an emerging field of research that aims to comprehensively investigate individuals' environmental exposures and how these exposures relate to health outcomes. Liquid chromatography-tandem mass spectrometry is widely used in exposomics studies. Me…
  pubmed Pang Z, Lu Y, Zhou G, Ou H 等 2026 Aug 17 置信度 0.82
• Genome sequencing reveals high diagnostic yield in children with severe sporadic developmental language disorder.
  A developmental language disorder (DLD) is a neurobiological condition characterized by impaired language development despite adequate linguistic input and normal intelligence. The role of monogenic causes in the pathogenesis of DLD is largely unknown and diag…
  pubmed Kennis MGP, van Haaften L, van Hulst K, Pfundt R 等 2026 Aug 17 置信度 0.82
• BIOMARKERS DISCOVERY IN TYPE 2 DIABETES MELLITUS: FROM OMICS TECHNOLOGIES TO CLINICAL PRACTICE
  Background: Type 2 diabetes mellitus (T2DM) is caused by complex pathophysiological processes including progressive insulin resistance, pancreatic β-cell dysfunction, chronic systemic inflammation and altered interorgan metabolic communication1. The ability of…
  datacite Manisha, Soma Sekhar Pulamarasetti*, Omkar Rai, Karan Gupta, Shivlal Yadav 2026 置信度 0.66
• BIOMARKERS DISCOVERY IN TYPE 2 DIABETES MELLITUS: FROM OMICS TECHNOLOGIES TO CLINICAL PRACTICE
  Background: Type 2 diabetes mellitus (T2DM) is caused by complex pathophysiological processes including progressive insulin resistance, pancreatic β-cell dysfunction, chronic systemic inflammation and altered interorgan metabolic communication1. The ability of…
  datacite Manisha, Soma Sekhar Pulamarasetti*, Omkar Rai, Karan Gupta, Shivlal Yadav 2026 置信度 0.66
• Technological forecasting for scientific and technological human resources- final report 2020
  This study was conducted as part of a four-year tender for the National Council for Research and Development in the Ministry of Science and Technology. The objective of this study was to execute forecasts of the needs of scientific and technological personnel …
  datacite Daphne Getz, Tsipy Buchnik, Vered Gilad, Ella Barzani 等 2021 置信度 0.66 Human CapitalScience and Technology
• Mapping of National Research Infrastructures in Israel: updated mapping of Israel research infrastructures and international research infrastructures, which are used by Israeli researchers
  The following is a summary of additional research conducted by the Samuel Neaman Institute following research conducted in 2010 "Mapping of Research Infrastructures in Israel" The purpose of the latter was to compile a database which would constitute the basis…
  datacite Daphne Getz, Vered Gilad, Bella Zalmanovich 2013 置信度 0.66 Academic CooperationAcademic ResearchInfrastructureResearch & Development
• NaVscape: a manually curated, uniformly reprocessed transcriptomic resource for SCN1A- and SCN2A-related disorders
  Pathogenic variants in SCN1A and SCN2A, the paralogous genes encoding the voltage-gated sodium channels NaV1.1 and NaV1.2, cause severe neurodevelopmental and epileptic disorders whose molecular consequences have been profiled across many models. These dataset…
  datacite Mamede, Izabela, Marinho, Bárbara, Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas 等 2026 置信度 0.66
• NaVscape: a manually curated, uniformly reprocessed transcriptomic resource for SCN1A- and SCN2A-related disorders
  Pathogenic variants in SCN1A and SCN2A, the paralogous genes encoding the voltage-gated sodium channels NaV1.1 and NaV1.2, cause severe neurodevelopmental and epileptic disorders whose molecular consequences have been profiled across many models. These dataset…
  datacite Mamede, Izabela, Marinho, Bárbara, Costa-Ferro, Zaquer Suzana Munhoz, Souza, Bruno Solano de Freitas 等 2026 置信度 0.66
• Frizzled receptors: gatekeepers of Wnt signaling in development and disease
  Frizzled (FZD) receptors are a subset of G-protein-coupled receptors (GPCRs), the largest class of human cell surface receptors and a major target of FDA-approved drugs. Activated by Wnt ligands, FZDs regulate key cellular processes such as proliferation, diff…
  datacite Stroman, Grace C., Fulton, Camryn J., Martinez-Marin, Dalia, Pruitt, Kevin 2025 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Cauris_CladeTyper_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/Cauris_CladeTyper_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/TheiaEuk_ONT_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• github.com/theiagen/public_health_bioinformatics/TheiaEuk_ONT_PHB
  Public Health Bioinformatics (PHB) The Public Health Bioinformatics Bioinformatics repository contains workflows for genomic characterization, submission preparation, and genomic epidemiology of pathogens of public health concern. Introduction Find the extensi…
  datacite theiagen 2026 置信度 0.66
• Reproducible computational vignettes for the CRISPR-perturbation multi-omics identifiability review
  Code and result files that regenerate the illustrative computational analyses in the review 'When can CRISPR-perturbation multi-omics support a causal claim? A method-selection framework for livestock functional genomics' (V. Asediya, submitted to Briefings in…
  datacite Asediya, Varunkumar 2026 置信度 0.66 CRISPR perturbationcausal inferencecausal discoverymulti-omics integrationsingle-cell CRISPR screens
• Vitellogenin Genes: Master Regulators of Insect Fertility and Emerging Targets for Biomedical Control
  This comprehensive review synthesizes research on vitellogenin (Vg) genes, establishing them as master regulators of insect fertility and prime targets for biocontrol. Vitellogenin, the primary yolk precursor protein, is synthesized mainly in the fat body unde…
  datacite reproductive biological science 2026 置信度 0.66 vitellogeninvitellogenin receptorinsect fertilityRNA interferenceRNAi
• Vitellogenin Genes: Master Regulators of Insect Fertility and Emerging Targets for Biomedical Control
  This comprehensive review synthesizes research on vitellogenin (Vg) genes, establishing them as master regulators of insect fertility and prime targets for biocontrol. Vitellogenin, the primary yolk precursor protein, is synthesized mainly in the fat body unde…
  datacite reproductive biological science 2026 置信度 0.66 vitellogeninvitellogenin receptorinsect fertilityRNA interferenceRNAi
• The Cognitive Genomics of Von Economo Neurons in the Anterior Insular Cortex under Clinical Stress: A Systematic Review
  Background and RationaleVon Economo Neurons (VENs) are large, spindle-shaped bipolar projection neurons located primarily in layer Vb of the anterior insular cortex (AIC) and the anterior cingulate cortex (ACC). Characterized by their unique morphology and loc…
  datacite Barath Kumar TR 2026 置信度 0.66 Medicine and Health SciencesLife Sciences
• Tests of Robustness in Peer Review
  Purpose: The purpose of this dissertation is to investigate the feasibility of using tests of robustness in peer review. This study involved selecting three high-impact papers which featured open data and utilized bioinformatic analyses but provided no source …
  datacite Leipzig,Jeremy 2021 置信度 0.66 BioinformaticsMetadataPeer reviewReproducibilityReproducible research
• Novel pathogenic variant in a mild case of type B molybdenum cofactor deficiency: case report and literature review
  Abstract Background Molybdenum cofactor deficiency (MoCD) is a rare metabolic disorder caused by pathogenic variants in the highly conserved biosynthetic pathway of molybdenum cofactor (MoCo), resulting in sulfite intoxication. MoCD may present in a clinically…
  crossref Morgan Kinsinger, Jelena Ivanisevic, Divakar S. Mithal 2024-12-18T15:26:04Z 置信度 0.70
• Genotype-Phenotype Analysis of 8q24.3 Duplication and 21q22.3 Deletion in a Chinese Patient and Literature Review
  <b><i>Introduction:</i></b> Copy number variants (CNVs) are responsible for many patients with short stature of unknown etiology. This study aims to analyze clinical phenotypes and identify pathogenic CNVs in a patient with short statur…
  crossref Huihui Sun, Naijun Wan 2021-07-15T21:00:35Z 置信度 0.70
• Book Review Fundamentals of Molecular Biology
  crossref 2012-06-28T03:23:45Z 置信度 0.70
• The Genomics of Emerging Pathogens
  Globalization and industrialization have dramatically altered the vulnerability of human and animal populations to emerging and reemerging infectious diseases while shifting both the scale and pace of disease outbreaks. Fortunately, the advent of high-throughp…
  crossref Cadhla Firth, W. Ian Lipkin 2013-09-04T20:32:53Z 置信度 0.70
• Review of: The identification of the replicative helicase loader gene dciA within the Helicobacter pylori genome challenges current replication initiation models for this bacterium. Round#1/Reviewer#2
  crossref 2026-02-02T16:48:18Z 置信度 0.70