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• Investigating the Potential of Proso Millet (Panicum miliaceum L.) as a Functional Food
  Abstract Proso millet (Panicum miliaceum L.) is among the earliest domesticated millet species and serves as a vital staple food for populations living in arid and semi-arid regions worldwide. This review highlights its rich nutritional profile, including high…
  datacite Tahere Razzaghi1, Fatemeh Naderi2, Maryam Salami1,3*, Gholamreza Askari4, Najmeh Salehi5 2025 置信度 0.66
• Supplemental Material for: A standardized framework to assess the clinical actionability of genes and associated conditions for population-based genomic screening
  Introduction: As population-based genomic screening (PGS) programs are increasingly implemented, standardized, evidence-based approaches are needed to support decision-making about which genetic findings should be returned based on clinical actionability. The …
  datacite figshare admin karger, Jessica Ezzell Hunter, Caitlin G. Allen, Jonathan S. Berg 等 2026 置信度 0.66 Medicine
• Supplemental Material for: A standardized framework to assess the clinical actionability of genes and associated conditions for population-based genomic screening
  Introduction: As population-based genomic screening (PGS) programs are increasingly implemented, standardized, evidence-based approaches are needed to support decision-making about which genetic findings should be returned based on clinical actionability. The …
  datacite figshare admin karger, Jessica Ezzell Hunter, Caitlin G. Allen, Jonathan S. Berg 等 2026 置信度 0.66 Medicine
• Targeting Inflammatory, Fibrotic, Hemodynamic, and Metabolic Pathways in Chronic Kidney Disease: Emerging Pharmacotherapies and Precision Treatment Strategies
  Chronic kidney disease (CKD) is a progressive and heterogeneous disorder that remains a major cause of premature mortality, cardiovascular morbidity, and kidney failure worldwide. Although renin–angiotensin system inhibitors, sodium–glucose cotransporter 2 inh…
  datacite North American Academic Research 2026 置信度 0.66
• Targeting Inflammatory, Fibrotic, Hemodynamic, and Metabolic Pathways in Chronic Kidney Disease: Emerging Pharmacotherapies and Precision Treatment Strategies
  Chronic kidney disease (CKD) is a progressive and heterogeneous disorder that remains a major cause of premature mortality, cardiovascular morbidity, and kidney failure worldwide. Although renin–angiotensin system inhibitors, sodium–glucose cotransporter 2 inh…
  datacite North American Academic Research 2026 置信度 0.66
• Egyptian cotton: harnessing genetic diversity, molecular tools, fiber anatomy, and innovation for a climate-smart future
  Abstract Egyptian cotton, derived primarily from Gossypium barbadense L., has shaped the country’s agricultural economy and international reputation for nearly two centuries. Among these, the Giza varieties—renowned for their exceptional fiber length, fineness…
  datacite Ibrahim A. A. Mohamed, Usama Abdel Hameid Abdel Razek, Junjuan Wang, Wuwei Ye 等 2026 置信度 0.66 Genetics
• Egyptian cotton: harnessing genetic diversity, molecular tools, fiber anatomy, and innovation for a climate-smart future
  Abstract Egyptian cotton, derived primarily from Gossypium barbadense L., has shaped the country’s agricultural economy and international reputation for nearly two centuries. Among these, the Giza varieties—renowned for their exceptional fiber length, fineness…
  datacite Ibrahim A. A. Mohamed, Usama Abdel Hameid Abdel Razek, Junjuan Wang, Wuwei Ye 等 2026 置信度 0.66 Genetics
• Topology, Autocatalysis, and Epigenetic Control: How Network Architecture Shapes Biological State Transitions Across Scales
  Version 2 — revised in response to an external structural review and an automated critique pass. See "Response to Review" appendix in the PDF for the change log. A candidate structural pattern emerges across several recent preprints in molecular networks, popu…
  datacite Saluca Agentic AI Research Team 2026 置信度 0.66 AI-drafted synthesisarXivpreprint reviewv2
• Fabry Disease: An Updated Perspective and Review of Treatment and Therapies.
  Fabry disease (FD) is a progressive, multisystemic, X-linked lysosomal storage disorder that when untreated leads to decreased quality of life, chronic pain, and end organ disease; however, advances in therapy have significantly altered its original natural hi…
  pubmed Laney DA, Martin MM, Suzuki A, Shankar SV 等 2026 Aug 22 置信度 0.82
• Integrative Omics of Eosinophils in Asthma and COPD: Deciphering Molecular Signatures for Targeted Therapy.
  Eosinophils are central effector and regulatory cells in asthma and eosinophilic respiratory disease, and a clinically relevant subset in a proportion of patients with chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap. While eosinophil count…
  pubmed Miyata J, Sunata K, Sasaki H, Chubachi S 等 2026 Aug 22 置信度 0.82
• Homeobox genes in endocrine tumorigenesis: mechanisms, tumor microenvironment interaction, and therapeutic potential.
  The homeobox (HOX) gene family is a highly conserved group of transcription factors, important for embryonic patterning, positional identity, and lineage commitment. Although many HOX genes are largely silenced in adult endocrine tissues, emerging evidence sug…
  pubmed Kong S, Zhang K, Kan C, Han F 等 2026 Aug 22 置信度 0.82
• Skeletal dysplasias of the parathyroid hormone signaling cascade: radiological manifestations and molecular mechanisms.
  Recent classification of skeletal dysplasias has reclassified disorders according to their underlying pathophysiologic mechanisms. The latest nosology of skeletal dysplasias introduced a new pathogenic category termed "skeletal disorders of the parathyroid hor…
  pubmed Tsujioka Y, Handa A, Calder AD, Cavalcanti DP 等 2026 Aug 22 置信度 0.82
• Integrating Artificial Intelligence with Global Genomic Resources: A Narrative Review of Implications for Precision Medicine.
  This review aimed to explore how artificial intelligence can be integrated with global genomic resources and to examine its implications for advancing precision medicine, with particular attention to population diversity, predictive modeling, and clinical tran…
  pubmed Alam T, Saha K, Rony MKK, Shahi D 等 2026 置信度 0.82
• Enterovirus infections in children.
  Enteroviruses (EVs), which include numerous types, are among the most common pathogens causing infections in children. EVs can cause diverse diseases, including herpangina, hand-foot-and-mouth disease, myocarditis, pneumonia, meningitis, encephalitis, and acut…
  pubmed Chen X, Guo L, Lei X, Zhao L 等 2026 Aug 21 置信度 0.82
• Engineered platforms for melanogenesis research: Bridging synthetic biology, bioengineering, and biomimetics.
  Melanogenesis, the biological process responsible for melanin synthesis, plays a critical role in determining skin pigmentation and providing photoprotection. Dysregulation of this pathway leads to a wide range of pigmentary disorders that affect a significant…
  pubmed Anika B, Tarkunde A, Swarna BS, Nayak UY 等 2026 Aug 21 置信度 0.82
• Targeting Cytoskeleton and Cell Motility: Past and Novel Strategies for Cancer Therapy.
  Cytoskeletal reorganization is fundamental to essential cellular processes, including shape maintenance, migration, adhesion cytokinesis, and phagocytosis, and its dysregulation is a hallmark of tumor progression. In cancer cells, altered cytoskeletal dynamics…
  pubmed Paradisi L, Trabalzini L, Finetti F 2026 置信度 0.82
• The Double-Edged Sword of Genomic DNA Methylation: Orchestrating Gastric Carcinogenesis and Shaping Precision Oncology.
  This article systematically elaborates on the dual role of DNA methylation in the initiation and progression of gastric cancer and its potential clinical applications in precision oncology. As a core epigenetic mechanism, DNA methylation drives the multistage …
  pubmed Chen X, Luo C, Wen W 2026 置信度 0.82
• Regulation of the Wnt/β-Catenin Signaling Pathway by Non-Coding RNAs in Esophageal Squamous Cell Carcinoma: Mechanisms, Translational Relevance, and Therapeutic Implications.
  Esophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive malignancy characterized by a poor long-term prognosis. Aberrant activation of the canonical Wnt/β-catenin pathway serves as a central oncogenic driver in ESCC, with large-scale genomic ana…
  pubmed Han C, Hou M, Yang R, Wei X 等 2026 置信度 0.82
• Stage-Specific Regulation of Ubiquitination Modifications and Prospects for Targeted Therapy in Triple-Negative Breast Cancer.
  Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by poor clinical outcomes. Owing to the absence of estrogen receptors, progesterone receptors, and Human Epidermal Growth Factor Receptor 2 (HER2) expression, TNBC sho…
  pubmed Wang Y, Huang W, Lin Q, Cai H 等 2026 置信度 0.82
• Recent advances in deep learning for leukemia diagnosis: a scoping review of diagnostic modalities and fusion-based approaches.
  The diagnosis of leukemia is inherently a multimodal process that combines morphological evaluation, immunophenotyping, molecular profiling and standard laboratory tests. Deep learning techniques have been adopted across all components of the diagnostic proces…
  pubmed Afsar P, Navamani TM 2026 置信度 0.82
• From fragmented to integrated surveillance in LMICs: digital pathways for outbreak detection and vaccine intelligence.
  Low- and middle-income countries (LMICs) often rely on fragmented, disease-specific surveillance systems that produce delayed and incomplete data. Recent outbreaks, including COVID-19, have highlighted the urgent need for integrated, real-time digital surveill…
  pubmed Francis DL, Reddy SSP 2026 置信度 0.82
• Gene signatures of palmitoylation and fatty acid metabolism predict prognosis and immunotherapy response in breast cancer patients by machine learning, single-cell analysis, and experimental validation.
  Palmitoylation and dysregulated fatty acid metabolism are key components of tumor metabolic reprogramming and play important roles in the initiation, progression, and immune regulation of breast cancer (BRCA). However, their systemic molecular characteristics …
  pubmed Zhang Z, Fu Y, Zhou Y, Zhou X 等 2026 置信度 0.82
• Structured peptides as vaccine antigens against infections.
  The onset of a new infection by a pathogen requires a rapid and prompt response from the body. Here, we present a simple and effective strategy to stimulate antibody production by grafting immunogenic peptides onto a beta-strand peptide scaffold. Analysis of t…
  pubmed Trappetti C, van Ingen H, Falconi M, Romeo A 等 2026 置信度 0.82
• Mycoviruses as Biocontrol Agents: Potential Applications for Managing Pests and Diseases of Oilseed Rape (Brassica napus).
  Oilseed rape (Brassica napus) production faces a wide range of biotic threats. Pests typically pose a greater threat than diseases to oilseed rape, yet both vary considerably across the major cultivating regions. Management strategies often rely heavily on the…
  pubmed Aston HJ, Coutts RHA, Huang YJ, Kotta-Loizou I 2026 Jul-Aug 置信度 0.82
• Genetics in Heterotaxy: A Case Series and Literature Review on DNAH9, PKD1L1, MMP21, and GDF1.
  Heterotaxy (HTX) is a rare condition characterized by complex congenital heart defects and a wide spectrum of extracardiac abnormalities that significantly impact survival. While molecular diagnosis is essential for clinical management, next-generation sequenc…
  pubmed Ho TBT, Coudert A, Do TTH, Le TTT 等 2026 Aug 22 置信度 0.82
• DNA Methylation Profiling in IDH-Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation.
  Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define a major subgroup of adult-type diffuse gliomas and induce accumulation of D-2-hydroxyglutarate, resulting in extensive DNA and histone methylation changes. This epigenetic reprogramming underlies the…
  pubmed Tralongo P, Ricciardi G, Ballato M, Fiorentino V 等 2026 Aug 置信度 0.82
• Pulmonary Cryptococcosis in Apparently Immunocompetent Hosts: Host Susceptibility, Occult Immunodeficiency and Clinical Implications.
  Pulmonary cryptococcosis (PC) in apparently immunocompetent hosts-now the majority of non-HIV cases in Asia-cannot be explained by the traditional opportunistic infection paradigm. Three epidemiological observations point toward occult immune susceptibility: f…
  pubmed Ma R, Yang X 2026 Aug 置信度 0.82
• Landscape of p53/TP53 in gastric carcinogenesis and precancerous lesions: Global trends and future directions based on bibliometric analysis (1992-2026).
  Gastric precancerous lesions (GPL) represent defined intermediate stages in the multistep cascade of gastric carcinogenesis leading to gastric cancer (GC). The literature identifies TP53 mutations as a decisive genomic event driving the transition from dysplas…
  pubmed Zhao W, Du X, Yi L, Yu L 等 2026 Aug 21 置信度 0.82
• A systematic review of artificial intelligence in small ruminant production systems: applications, performance outcomes, and reported implementation challenges.
  Sheep and goats are essential components of global livestock systems, supporting smallholder livelihoods and contributing substantially to meat, milk, and fiber production. However, many small ruminant production systems remain extensive and constrained by lim…
  pubmed Ghazy AA, Abu El-Naser IA 2026 Aug 20 置信度 0.82
• A deep learning-derived risk score model from digital pathology to forecast nivolumab outcomes in gastric carcinoma.
  The PD-L1 combined positive score (CPS) is a biomarker predicting responses in gastric cancer (GC) immunotherapy.
  pubmed Hong Y, Hwang I, Kim MJ, Kim Y 等 2026 Aug 21 置信度 0.82
• Mutations of the DICER1 gene among children and adolescents with thyroid cancer: a systematic review.
  The DICER1 gene located on chromosome 14q, essential for the maturation of miRNAs, is commonly associated with multinodular goiter and thyroid carcinomas. We aimed to systematically search the literature and identify mutations in the DICER1 gene associated wit…
  pubmed Dimaki A, Kotanidou EP, Tsinopoulou VR, Dimakis IK 等 2026 Aug 21 置信度 0.82
• Adult granulosa cell tumor of the ovary: a concise clinicopathologic overview.
  pubmed Walczak SG, Okoye EI 2026 Aug 1 置信度 0.82
• A formyl axis links metabolism to translation.
  Initiator methionine tRNA is a key regulator of translation and cell growth. Recent work places formyl chemistry as a regulatory nexus across three molecular layers. In the protein layer, N-formylmethionine supports initiator tRNA recognition and stress-respon…
  pubmed Niehrs C 2026 Aug 21 置信度 0.82
• Cycling off: a novel mechanism for differential cell cycle-dependent histone gene expression.
  The precise regulation of the replication-dependent histone genes during S phase is essential for packaging newly synthesized DNA and maintaining genome integrity. Identifying the roles of specialized factors that regulate histone biosynthesis is crucial for a…
  pubmed Hodkinson LJ, Larschan EN 2026 Aug 21 置信度 0.82
• From physiology to food applications: Kluyveromyces marxianus as a key player for innovation in probiotic attributes, fermented foods and functional food ingredients.
  Kluyveromyces marxianus is a non-conventional yeast of growing interest in food biotechnology due to rapid growth, thermotolerance, broad substrate use, and metabolic versatility. Current knowledge remains fragmented across genomics, physiology, probiotic trai…
  pubmed Huang K, Wu L, Huang S, Gui X 等 2026 Oct 31 置信度 0.82
• Long noncoding RNAs and diabetic retinopathy: Current understanding, future directions and challenges.
  Diabetic retinopathy remains as the leading cause of preventable blindness in working-aged people. The pathophysiology of this sight-threatening disease is complex and involves intricate interactions among metabolic, hemodynamic and epigenetic pathways, leadin…
  pubmed Kowluru RA, Kaur I, Wang S, Kaarniranta K 等 2026 Aug 21 置信度 0.82
• Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026).
  ecombinant human growth hormone (rhGH) has been used for four decades under a largely population-based dosing paradigm, yet growth response varies substantially among children with apparently similar auxological phenotypes. Advances in genomics, GH-insulin-lik…
  pubmed Soliman AT, Alyafei F, Alaaraj N, Hamed N 等 2026 Aug 17 置信度 0.82
• The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding global collaboration in pediatric cancer etiology research.
  Childhood cancers are rare, but incidence has risen modestly in countries with robust registration, partly reflecting improved diagnosis. In high-income countries, cancer is the leading cause of disease-related death in children. Marked inequities in incidence…
  pubmed Mora AM, Mejía-Arangure JM, Dockerty JD, Rashed WM 等 2026 Oct 置信度 0.82
• Targeting SIRT6: the design and therapeutic implications of activators and inhibitors.
  Sirtuin 6 (SIRT6) is an NAD + -dependent deacylase that maintains genomic stability, regulates metabolism, and influences aging, making it an attractive but challenging therapeutic target. Pharmacological modulation of SIRT6 holds promise for cancer and metabo…
  pubmed Shi Y, Han X, Li X, Li X 等 2026 Aug 20 置信度 0.82
• Mechanisms linking the gut microbiota to colorectal cancer development and progression.
  Colorectal cancer remains a leading cause of global cancer mortality, with a concerning rise in early-onset cases driven by complex interactions between environmental exposures, lifestyle factors, and host genetics. Mounting evidence indicates that gut microbi…
  pubmed Zheng H, Zhang W, Pang Q, Deng H 2026 Aug 17 置信度 0.82
• Unlocking the epigenetic code: future Frontiers in predictive biomarkers for intellectual disability in fragile X syndrome.
  Fragile X Syndrome (FXS) remains the leading inherited cause of intellectual disability (ID), yet the classic CGG repeat expansion on the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene often fails to provide a precise prognostic map for cognitive outcomes…
  pubmed Alatawi HA, Eldiasty JG 2026 Aug 10 置信度 0.82
• Lactiplantibacillus plantarum: Systems Biology of a Versatile Microbe.
  Lactiplantibacillus plantarum is a metabolically versatile lactic acid bacterium found in fermented foods and the human gastrointestinal tract. Its relatively large genome (3.0-3.6 Mb) features an open pan-genome with 1,436-2,100 core genes and over 13,00…
  pubmed Chen Y, Rizwan M, Nawaz A, Waheed MI 等 2026 Aug 21 置信度 0.82
• Vitamin D₃ in cancer prevention and therapy: molecular mechanisms, clinical evidence, and future perspectives.
  Vitamin D 3 , also known as cholecalciferol, is a fat-soluble secosteroid that plays a critical role in regulating calcium and phosphate homeostasis and supporting bone health. Recent studies have highlighted its broad physiological and therapeutic application…
  pubmed Khan SU, Saeed S, Sheikh HN, Ali A 等 2026 Aug 21 置信度 0.82
• Deciphering the role of sirtuins in cancer immunoregulation through molecular cross-talk and docking-based interaction.
  The Sirtuin family (SIRT1-SIRT7) of NAD + -dependent histone deacetylases (HDACs) serves as a fundamental regulator of cellular homeostasis, governing protein acylation, metabolic flux, and genomic integrity. Cancer cells often bypass the pre-defined cellular …
  pubmed Saha A, De S, Chattopadhyay S, Dasgupta S 等 2026 Aug 21 置信度 0.82
• Periodontitis as a Modulator of Malignant Transformation in Oral Potentially Malignant Disorders: A Narrative Review of Biological Mechanisms and Clinical Implications.
  Oral potentially malignant disorders (OPMDs) comprise a heterogeneous group of lesions with a variable risk of progression to oral squamous cell carcinoma (OSCC). Although conventional risk assessment relies primarily on clinical and histopathological features…
  pubmed Pieretto G, Sansavini M, Cortes ARG, Bacci C 2026 Aug 21 置信度 0.82
• Binding specificity of IgG antibodies to mycobacterial DNA in plasmas of patients with tuberculosis and healthy controls.
  Anti-DNA antibodies are a diverse set of antibodies that bind to structures on DNA that vary with clinical setting. In systemic lupus erythematosus (SLE), anti-DNA antibodies interact with the B-DNA backbone, binding DNA irrespective of species origin. In cont…
  pubmed Garza Reyna A, Spencer D, Gautam U, Pisetsky DS 2026 Aug 4 置信度 0.82
• Molecular classification and precision therapy in gastric cancer: Current advances and future perspectives (Review).
  The emergence of molecular classifications for gastric cancer (GC), The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG), has advanced targeted and immunotherapies, but their clinical translation faces real‑world obstacles including hig…
  pubmed Xia S, Zhang X, Tang L, Li A 等 2026 Oct 置信度 0.82
• Phylogenomic subsampling and upsampling for efficient evolutionary analyses of big data.
  Long runtimes, high memory demands, and reliance on high-performance computing impede phylogenomic analyses. We review a scalable phylogenomic subsampling with upsampling (PSU) framework, in which small subsamples of sites from a concatenated alignment are exp…
  pubmed Kumar S, Tamura K, Sharma S 2026 Aug 21 置信度 0.82
• Diagnostic performance of panfungal PCR on tissue specimens for the diagnosis of invasive fungal diseases: a systematic review and meta-analysis of the Fungal PCR Initiative (FPCRI).
  Invasive fungal diseases are difficult to diagnose because of the limited sensitivity of culture. Panfungal PCR amplicon sequencing assays (targeting ribosomal RNA, such as 18S, 28S, ITS) are recommended for fungal identification in histopathology samples show…
  pubmed Filippidis P, El Khoury C, Cruciani M, Alanio A 等 2026 Aug 21 置信度 0.82
• Methodological strategies for mapping HLA susceptibility loci in vitiligo: A focused minireview.
  Some genes, such as HLA class I and class II genes, play important roles in the pathogenesis of vitiligo and its associated autoimmune diseases. Attempts to identify these genes have involved several approaches, including analysis of HLA expression patterns, g…
  pubmed Bouayad A 2026 Sep 20 置信度 0.82
• CRISPR technologies for detecting DNA and RNA methylation: Mechanisms, platforms, and translational opportunities.
  DNA and RNA methylation are key epigenetic and epitranscriptomic modifications involved in gene regulation, genome stability, RNA metabolism, and disease progression. Aberrant methylation patterns in cell-free DNA and RNA have emerged as valuable biomarkers fo…
  pubmed Chen K, Yang B, Sang R, Chen W 等 2026 Aug 19 置信度 0.82
• Antimicrobial Stewardship, Laboratory Surveillance, and Quality Management in Africa: A Narrative Review of Challenges and Opportunities for Integrated AMR Control.
  Antimicrobial resistance (AMR) is a growing public health threat that disproportionately affects African countries due to high infectious disease burdens, widespread antimicrobial misuse, weak health systems, inadequate diagnostic capacity, and fragmented surv…
  pubmed Owoicho AW, Edward M 2026 Aug 置信度 0.82
• Artificial intelligence in onco-anaesthesia: Current applications, challenges, and future directions.
  Artificial intelligence (AI) is transforming onco-anaesthesia by shifting practice from reactive physiological management toward predictive and precision-based care. This review outlines current AI applications across the perioperative cancer pathway. Preopera…
  pubmed Sirohiya P, Maurya P, Gupta N, Ratre BK 等 2026 Sep 20 置信度 0.82
• Chronic postsurgical pain in children: Current evidence and clinical perspectives.
  The chronification of acute pain following surgery is increasingly recognized, with a reported prevalence of 10%-63%, likely reflecting the increasing number of surgical interventions performed in the pediatric population. This pain is more severe after high-r…
  pubmed Godhwal P, Gupta A, Sirohi A, Gupta N 2026 Sep 9 置信度 0.82
• Unravelling the nexus of non-coding RNAs in cancer stemness and therapeutic drug resistance.
  Cancer stem cells (CSCs) play a pivotal role in tumor initiation, progression, and therapy resistance. Emerging evidence suggests that non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), intricately regulate CSC propertie…
  pubmed Chen S, Dakal TC, Bhushan R, Arya DK 等 2026 置信度 0.82
• Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.
  PIWI-interacting RNAs (piRNAs), PIWI proteins, and piRNA biogenesis-associated proteins form a conserved RNA network that protects germline genome integrity and is increasingly linked to cancer biology. Most cancer reviews have emphasized altered piRNA abundan…
  pubmed Peng S, Wei B, Li X, Li E 2026 置信度 0.82
• Epigenetics, bacterial metabolites and type 2 diabetes: a new view of gut-genome interactions.
  Type 2 diabetes (T2D) is traditionally viewed as a disorder of glucose homeostasis, yet growing evidence suggests that its pathogenesis is deeply influenced by interactions between the gut microbiota and host gene regulation. Bacterial metabolites have emerged…
  pubmed Taqi AF, Albuloushi A, Saleh A, Alqaderi F 等 2026 置信度 0.82
• Editorial: Genome editing in poultry and livestock.
  pubmed Zhang J, Shang L 2026 置信度 0.82
• In vivo CAR T cells on the highway: a roadmap for the next decade.
  Chimeric antigen receptor (CAR) T cell therapy has shown efficacy in the treatment of hematological malignancies. However, the application to a broader patient population is still limited by the complex logistics in coordinating the lymphodepleting chemotherap…
  pubmed Barden M, Harrer DC, Abken H 2026 Aug 23 置信度 0.82
• Urinary Extracellular Vesicles as a Source of Biomarkers for Kidney Allograft Rejection: A Systematic Review.
  Kidney transplant rejection remains a leading cause of graft loss, and diagnosis still depends largely on invasive biopsies. Urinary extracellular vesicles (uEVs) offer a potential noninvasive alternative for detecting allograft rejection through molecular pro…
  pubmed Ambarsari CG, David NI, Kim DH, Piccinini AM 等 2026 Aug 21 置信度 0.82
• The history of Wolbachia and heartworm.
  Wolbachia is the most widespread endosymbiont in animals, and its discovery in Dirofilaria immitis significantly advanced our understanding of heartworm disease (HWD). In 1995, Sironi and colleagues from the universities of Milan and Pavia, Italy, published a …
  pubmed Vismarra A, Fozzer M, McCall JW, Genchi M 等 2026 Aug 20 置信度 0.82
• Human endogenous retroviruses as immune-related prognostic biomarkers in pancreatic cancer.
  Human endogenous retroviruses (HERVs) may modulate antitumor immunity and prognosis in pancreatic cancer (PC), but reported findings remain heterogeneous.
  pubmed Toma PI, Gales LN, Ghiringhelli F, Trandafir A 等 2026 Aug 20 置信度 0.82
• RNA splicing in health and disease.
  RNA splicing expands the functional output of eukaryotic genomes by enabling individual precursor messenger RNA (pre-mRNA) to generate multiple mature transcripts with protein‑coding and regulatory properties. Its fidelity and plasticity depend on coord…
  pubmed Huang H, Yu Y, Zhou Q, Deng G 等 2026 Aug 21 置信度 0.82
• Toward the clinical application of long-read sequencing in repeat-expansion disorders.
  Repeat-expansion disorders (REDs) are a mechanistically and clinically well-defined subgroup of rare diseases caused by the expansion of short tandem repeats (STRs). These expansions can exceed several kilobases and show complex features, such as noncanonical …
  pubmed Benarroch L, Pešović J, Rossato M, Chen Z 等 2026 Aug 20 置信度 0.82
• Proteogenomics in human populations.
  In human population studies, proteogenomics integrates genomic and proteomic data to uncover how genetic variation shapes protein expression and function. A central focus of proteogenomics is the identification of protein quantitative trait loci (pQTL), which …
  pubmed Zhai R, Mälarstig A, Shen X 2026 Aug 20 置信度 0.82
• Diagnosis of hypochondroplasia: international Delphi consensus recommendations.
  Hypochondroplasia is a skeletal dysplasia caused by pathogenic variants in FGFR3 and characterized by disproportionate short stature and relative macrocephaly. Diagnostic uncertainty remains common, particularly in early childhood and in individuals with mild …
  pubmed Dauber A, Cheung MS, Hoover-Fong J, Fredwall SO 等 2026 Aug 20 置信度 0.82
• The hallmarks of skeletal muscle health.
  Skeletal muscle is a central determinant of organismal health. Preserving muscle quality is therefore critical for preventing disease and sustaining quality of life across the lifespan. Despite its central role, the field lacks a unifying framework that define…
  pubmed Vainshtein A, Blaauw B, De Bock K, Munoz-Canoves P 等 2026 Aug 20 置信度 0.82
• Advanced gene editing technologies for oncology mechanisms, applications, and clinical implementation.
  Advanced gene editing tools have transformed oncology by facilitating precise molecular therapies aimed at the hereditary basis of cancer. This thorough study examines the mechanisms, applications, and clinical implementation of advanced genome editing technol…
  pubmed Bindu S, Ash A, Sarkar K 2026 Aug 20 置信度 0.82
• Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.
  Microbial metabolism is a complex, emergent system driven by the coordinated interplay of intricate and dynamic molecular processes. To elucidate cellular behavior and enable biotechnological applications, quantitative models that address the inherent complexi…
  pubmed Lai YH, Lu T 2026 Aug 20 置信度 0.82
• Sirtuins in mitochondrial physiology and energy homeostasis.
  Mitochondrial sirtuins integrate cellular metabolic and energetic state with post-translational regulation of mitochondrial proteins, thereby influencing bioenergetics, redox homeostasis, and metabolic flexibility. Despite extensive study of individual sirtuin…
  pubmed Kaur A, Seetharam UK 2026 置信度 0.82
• Beyond One Gene: a systematic review of layered evidence for antileishmanial resistance in Leishmania infantum.
  Antileishmanial drug resistance in Leishmania infantum is a major challenge for visceral leishmaniasis control, yet the genetic evidence remains fragmented across functional, genomic, structural and expression-based studies. This systematic review mapped paras…
  pubmed Costa RV, Cerilo-Filho M, Almeida MNG, Silva AA 等 2026 Aug 20 置信度 0.82
• Digital droplet PCR and liquid biopsy in acute myeloid Leukemia: bridging translational research and clinical practice.
  Acute myeloid leukemia (AML) is a genetically heterogeneous and dynamically evolving malignancy in which morphologic remission does not necessarily indicate eradication of disease. Bone marrow examination remains central to diagnosis and response assessment, y…
  pubmed El-Sehrawy AAMA, Abohassan M, Shonazarov I, Abd HH 等 2026 Aug 20 置信度 0.82
• Immunophenotyping and Molecular Patterns of Prostate Cancer in East Africa: Diagnostic and Prognostic Implications-A Systematic Review.
  Prostate cancer disproportionately affects Sub-Saharan African men, who often present with aggressive, late-stage disease. This systematic review synthesizes contemporary evidence on the immunophenotyping and molecular patterns of prostate cancer in East Afric…
  pubmed Posite CM, Wabinga H, Atwine R, Vahwere BM 等 2026 Jul 28 置信度 0.82
• Richter transformation: emerging immunologic strategies beyond chemoimmunotherapy.
  Richter transformation (RT) is an aggressive lymphoma that arises in patients with chronic lymphocytic leukemia (CLL), most commonly diffuse large B-cell lymphoma (DLBCL-RT). Outcomes remain poor with conventional chemoimmunotherapy, reflecting the role of inc…
  pubmed Li J, Dowling MR, Tam CS, Anderson MA 等 2026 Aug 20 置信度 0.82
• A Comprehensive Review of T-Cell Lymphoma Following CAR T-Cell Immunotherapy.
  While chimeric antigen receptor (CAR) T-cell therapy provides potential cure for patients with non-Hodgkin B-cell lymphomas/leukemias and plasma cell myelomas, rare reports of development of T-cell lymphomas(TCLs) in these patients have raised serious safety c…
  pubmed Shi W, Wang HY 2026 Aug 20 置信度 0.82
• Pathophysiology of developmental and/or epileptic encephalopathy with spike-wave activation in sleep: A diagnostic framework.
  Developmental and/or epileptic encephalopathy with spike-wave activation in sleep is a childhood epileptic encephalopathy spectrum where sleep-related spike-wave discharges drive neurocognitive regression during critical developmental periods. This narrative r…
  pubmed Rasheed A, Sekar S, Naqvi R, Dutta M 等 2026 Aug 20 置信度 0.82
• A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow.
  Recently, a number of studies have looked at the problem of privacy and data-sharing restrictions in the context of missing-genotype imputation servers. This relates to the most typical imputation pipelines which involve a whole-genome sequenced haplotype refe…
  pubmed Letaillandier A, Picard-Druet D, Ludwig TE, Marenne G 等 2026 置信度 0.82
• Comparative analysis of the karyotypes of Equus caballus and Equus asinus in the context of contemporary genomic data.
  Karyotypes of species within the genus Equus display considerable variation in chromosome number and are characterised by numerous structural rearrangements that have played a pivotal role in their evolutionary divergence and speciation. Equus caballus (horse)…
  pubmed Kowal-Mierzwa W, Bugno-Poniewierska M 2026 Aug 20 置信度 0.82
• Near-real-time whole-genome sequencing in hospital infection control: a narrative review.
  Hospital-acquired infections (HAIs) continue to pose a significant challenge to patient safety, partly because traditional microbiological methods slow down the identification of pathogens and outbreak detection. Near-real-time whole-genome sequencing (WGS) an…
  pubmed Singh T, Taufiq A, Jawed A, Akhter N 等 2026 Aug 20 置信度 0.82
• Genomic tales of wine yeasts: from domestication to functional innovation.
  Over the last decades, the yeast Saccharomyces cerevisiae has emerged as a key model for studying microbial domestication, particularly in the context of winemaking. The recent surge of population genomic data, encompassing thousands of genomes, has profoundly…
  pubmed Becerra-Rodríguez C, Devillers H, Legras JL, Galeote V 等 2026 Jan 5 置信度 0.82
• Genetic Research on Cardiac Channelopathies in African and African-Descent Populations: A Scoping Review.
  Cardiac channelopathies are inherited arrhythmias that can lead to sudden cardiac death. Despite Africa's extensive genomic diversity, African and African-descent populations remain underrepresented in genetic research, creating gaps in variant interpretation …
  pubmed Taib C, El Makhzen N, Abriel H 2026 Aug 20 置信度 0.82
• Genetic predictive links between oropharyngeal microecology and obstructive sleep apnea syndrome: expanding the perspective of etiology.
  Obstructive sleep apnea syndrome (OSAS), a global public health concern, is linked to oropharyngeal microbiota, but observational studies cannot confirm their causal association.
  pubmed Zhao L, Zhang Y, Lin L, Wang T 等 2026 置信度 0.82
• Transforming subcellular spatial transcriptomics: deep learning models for cell segmentation.
  Subcellular spatial transcriptomics (SSTs) is transforming biology by revealing where individual RNA molecules are located within intact tissues, providing unprecedented insight into how cells function and interact. Achieving this promise depends on accurately…
  pubmed Rathbun IA, Banskota N, Lehrmann E, Gorospe M 等 2026 Aug 10 置信度 0.82
• Quarantine as filter: a conceptual framework from early modern Venice.
  Lazzaretto Vecchio, founded in 1423 in the Venetian lagoon, is recognized as the earliest permanent quarantine hospital. For nearly three centuries it operated at a major maritime frontier. Historical records describe extensive epidemic mortality and mandate b…
  pubmed Vianello A, Tykot RH, Adapa SR, Ferreira GC 等 2026 置信度 0.82
• Mixed malaria infections: A critical review and Detect-Characterise-Act surveillance framework.
  Mixed malaria infections, involving concurrent Plasmodium species and/or multiple genetically distinct parasite clones, remain under-measured in routine malaria programmes despite implications for diagnosis, treatment, drug-resistance surveillance, and elimina…
  pubmed Igwe MC, Alum EU 2026 置信度 0.82
• Envafolimab - novel anti-PD-1/PD-L1 antibody in cancer treatment.
  The landscape of immunotherapy in oncology has markedly advanced with the development of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors, fundamentally reshaping cancer treatment by potentiating anti-tumor immune responses. PD-1/PD-L…
  pubmed Kciuk M, Kołat D, Wanke K, Kontek R 2026 置信度 0.82
• Novel targeted therapies for central nervous system involvement in chronic lymphocytic leukemia: A systematic review.
  Central nervous system (CNS) involvement in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare, diagnostically challenging, and historically associated with poor outcomes. Bruton tyrosine kinase (BTK) and B-cell lymphoma 2 (BCL2) inhibit…
  pubmed Al-Mashdali AF, Abdelraof MO, Mukhtar RM, Mohamed SF 2026 置信度 0.82
• GBS-based identification of Triticum timopheevii introgressions in a wheat pre-breeding population.
  Triticum timopheevii (2n = 4x = 28, GGA t A t ) is a valuable wild wheat relative for improving disease resistance and agronomic performance in bread wheat, although the detection of introgressed chromosomal segments remains challenging due to close genomic si…
  pubmed Gaál E, Uhrin A, Kalapos B, Holušová K 等 2026 置信度 0.82
• Editorial: One health approach to infection prevention and antimicrobial resistance.
  pubmed Abdel-Massih RM, Aziz RK, Daoud Z 2026 置信度 0.82
• Alzheimer's disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism.
  Hippocampal atrophy is frequently observed in neurodegenerative diseases such as Alzheimer's disease (AD) or hippocampal sclerosis of aging (HS-aging). Volume loss in the hippocampus is described as prodromal stage of dementia and has been associated with AD p…
  pubmed Olivé C, de Rojas I, Zhang L, Sotolongo-Grau O 等 2026 置信度 0.82
• A Novel Splice Variant in the COL1A1 Gene Leads to Exon 46 Skipping and Osteogenesis Imperfecta.
  Osteogenesis imperfecta (OI) is a clinical and genetic disorder characterised by bone fragility, growth deficiency and skeletal deformity. Ninety per cent of OI cases are attributable to autosomal dominant variants in the COL1A1 and COL1A2 genes.
  pubmed Zhang Y, Liu H, Yin A, Liu S 等 2026 置信度 0.82
• Gene-diet interaction between CETP rs3764261 and vegetarian diet on HDL-C levels: evidence for precision nutrition from the Taiwan Biobank.
  Precision nutrition seeks genotype-informed dietary guidance. We examined the associations of CETP rs3764261 and a vegetarian diet with high-density lipoprotein cholesterol (HDL-C) levels and the potential modification of this association by the variant in Tai…
  pubmed Chou YH, Tyan YS, Chang ST, Nfor ON 等 2026 置信度 0.82
• ARACRA: Automated RNA-seq Analysis for Chemical Risk Assessment.
  Transcriptomics data captures genome-wide gene expression changes through in vitro or in vivo studies and can be used in chemical risk assessment for characterizing and identifying the effects of chemicals. While several bioinformatics tools and pipelines addr…
  pubmed Sharma S, Kumar S, Biosca-Brull J, Deepika D 等 2026 置信度 0.82
• HLA class II alleles and haplotypes associated with susceptibility to type 1 diabetes and to type 1 diabetes with concomitant autoimmune diseases: a cross-sectional study from Eastern Croatia.
  Type 1 diabetes mellitus (T1D) is an autoimmune disease with a strong genetic predisposition, largely conferred by human leukocyte antigen (HLA) class II genes. Patients with T1D frequently develop additional autoimmune diseases (AIDs). However, data on HLA cl…
  pubmed Lekić I, Marczi S, Suver Stević M, Nešković N 等 2026 置信度 0.82
• Loss of epigenetic adaptation to a high-fat diet in alpha-synuclein transgenic mice.
  In humans, a high-fat diet and obesity are associated with a higher risk and accelerated progression of Parkinson's disease (PD). Similarly, in animal models a high-fat diet exacerbates PD-related phenotypes, including dopaminergic neurodegeneration, and alpha…
  pubmed Hoof V, Schaffner SL, Dever K, MacIsaac J 等 2026 置信度 0.82
• Identification of a nuclear transcriptional module associated with ERα and E2F/FOXM1 signaling across PAM50 breast cancer subtypes.
  Breast cancer is the most prevalent and lethal cancer among women worldwide. Although classification based on ERα, PR, and HER2 status guides treatment decisions, misclassification remains a challenge due to the complexity of ERα-associated transcr…
  pubmed Dozal-Luna AJ, Santuario-Facio SK, Cardona-Huerta S, Gómez-Macías GS 等 2026 置信度 0.82
• Personalized nutrition for healthy aging: precision diets based on genomic, metabolic, and microbiome profiles.
  The global increase in life expectancy has been accompanied by a parallel rise in the burden of chronic diseases, many of which are influenced by diet and lifestyle. Conventional dietary guidelines, though broadly beneficial, often fail to account for the wide…
  pubmed Reytor-González C, Román-Galeano NM, Castano Jimenez J, Oentiono OY 等 2026 置信度 0.82
• Targeting interleukin-6 in immune-mediated inflammatory diseases: Current strategies and emerging technologies.
  Immune-mediated inflammatory diseases (IMIDs) refer to a heterogeneous group of conditions driven by dysregulated immune responses that affect multiple organs and systems, leading to substantial morbidity and premature mortality. Accumulating evidence indicate…
  pubmed Ji P, Zhao P, Guo W, Cai S 等 2026 Aug 19 置信度 0.82
• Bacterial biosynthetic gene clusters.
  The concept of biosynthetic gene clusters (BGC) has been at the centre of the study of bacterial secondary metabolism during this century, allowing a major transition in how this elusive complex trait was historically investigated, from individual cases to cur…
  pubmed Barona-Gómez F 2026 Aug 19 置信度 0.82
• Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.
  Early-onset colorectal cancer (EOCRC), conventionally defined as colorectal cancer diagnosed before the age of 50 years, has become one of the most important and unsettling epidemiologic shifts in gastrointestinal oncology. This review critically synthesizes r…
  pubmed Grześkiewicz-Szostak M, Gęca K, Skórzewska M 2026 Aug 20 置信度 0.82