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• What the papers say: Text mining for genomics and systems biology
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• Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancer.
  europepmc 2026 置信度 0.80
• Connecting dots: Ligand-dependent allostery from protein interaction to gene regulation.
  europepmc 2026 置信度 0.80
• Super Enhancer RNAs Rewrite the Molecular Script of Complex Gene Regulation in the MDD Brain.
  europepmc 2026 置信度 0.80
• CREB gene regulation as a blood biomarker of neural sensitivity to social threat.
  europepmc 2026 置信度 0.80
• EL222-Based Optogenetic Gene Regulation in Methylotrophic Yeasts: Mechanisms, Applications, and Future Directions.
  Methylotrophic yeasts such as Pichia pastoris are widely used for heterologous protein production because they contain strong and tightly regulated promoters. However, the use of methanol as an inducer presents several practical challenges, including toxicity,…
  europepmc 2026 置信度 0.80
• Epigenetic Modulators: Role of Gut Microbiome in Transformation of Nutrient Bioactives and Host Gene Regulation.
  europepmc 2026 置信度 0.80
• Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.
  europepmc 2026 置信度 0.80
• Liquid-liquid phase separation induces stochastic oscillations in gene regulation.
  europepmc 2026 置信度 0.80
• The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells.
  europepmc 2026 置信度 0.80
• Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles
  europepmc 2026 置信度 0.80
• Thermodynamic control of gene regulation.
  europepmc 2025 置信度 0.80
• A reliable and verified dataset of functional miRNA-mRNA target interactions for gene regulation studies.
  europepmc 2026 置信度 0.80
• Gene regulation through exon junction complex modularity.
  europepmc 2025 置信度 0.80
• The allostery principle supports the symbolic character of signaling circuits: gene regulation provides a form of intelligence to living systems.
  europepmc 2026 置信度 0.80
• Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation.
  europepmc 2026 置信度 0.80
• The lncRNA CTD-2566 J3.1 orchestrates oncogenic gene regulation via chromatin interactions in luminal breast cancer.
  europepmc 2026 置信度 0.80
• Ribo-Tweezer: Rapid removal of ribosomal proteins reveals additional layers of post-transcriptional gene regulation.
  europepmc 2026 置信度 0.80
• <i>Arabidopsis Myo</i>-Inositol-1-Phosphate Synthases Moonlight in Nuclear Gene Regulation.
  europepmc 2026 置信度 0.80
• Co-transcriptional gene regulation in plants.
  europepmc 2026 置信度 0.80
• Molecular mechanisms of circadian clock-mediated gene regulation and their implications in leukemia.
  europepmc 2026 置信度 0.80
• Transcriptomic Profiling Reveals Immunometabolic Gene Regulation during a 24-Hour Cold Exposure Survival Simulation in Humans.
  europepmc 2026 置信度 0.80
• Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation.
  europepmc 2026 置信度 0.80
• Hypoxia-driven transcriptional activation of MIR100HG by HIF-1α contributes to adaptive gene regulation in hepatocellular carcinoma.
  europepmc 2026 置信度 0.80
• Compact transcriptional activators: Therapeutic gene regulation in ocular disease.
  europepmc 2026 置信度 0.80
• Probiotic-derived EPS-ZnO nanoparticles: therapeutic potential in colorectal cancer gene regulation.
  europepmc 2026 置信度 0.80
• Ecdysone and Hydroxyurea Induced Gene Regulation on Polytene Chromosome Puffing, Glue Protein Expression, and Pupation Site Preference in Drosophila melanogaster.
  europepmc 2026 置信度 0.80
• Disruption of HOX Gene Regulation by Bisphenol A and Its Analogs: Epigenetic and Molecular Insights in Developmental Toxicity.
  europepmc 2026 置信度 0.80
• Identifying gene regulation modules associated with tumor metastasis using a network decomposition approach and combinatorial fusion analysis.
  europepmc 2026 置信度 0.80
• Complementary constraints in germ and immune cells shape evolution of gene regulation and phenotype
  europepmc 2026 置信度 0.80
• A CRISPRi Gene Regulation System for Bifidobacteria.
  europepmc 2025 置信度 0.80
• Publisher Correction: The impact of exercise on gene regulation in association with complex trait genetics.
  europepmc 2026 置信度 0.80
• Transglutaminase 2 at the Interface of Gene Regulation and Antigen Processing in HLA-Restricted Immunity of Celiac Disease.
  europepmc 2026 置信度 0.80
• Compensatory Gene Regulation Following Survivin Inhibition in MDA-MB-231 Cells.
  europepmc 2026 置信度 0.80
• An Apple a Day? The Hypothesis of Cross-Kingdom Gene Regulation by Plant miRNAs in Mammals and Its Controversies.
  europepmc 2026 置信度 0.80
• Unveiling karyoskeletal dynamics in chromatin organization and gene regulation in haematopoietic cell physiology and pathology.
  europepmc 2026 置信度 0.80
• Photoperiod-driven gene regulation in the brain of <i>Chirostoma estor</i>: endocrine, metabolic, and epigenetic insights.
  europepmc 2026 置信度 0.80
• Individual-Specific Gaussian Graphical Models for Heterogeneous Populations with Application to Epigenetic Gene Regulation in Lung Adenocarcinoma
  europepmc 2026 置信度 0.80
• Dual Modes of Gene Regulation by CDK12
  europepmc 2025 置信度 0.80
• Paradoxical gene regulation explained by competition for genomic sites
  europepmc 2025 置信度 0.80
• Gene regulation in response to host sex and infection route in Brugia pahangi with new genome annotation.
  europepmc 2026 置信度 0.80
• Advances in miRNA research: Unraveling the complexities of gene regulation.
  europepmc 2025 置信度 0.80
• A magnetogenetic atlas of cytoskeleton-resolved gene regulation in mesenchymal stem cells.
  europepmc 2026 置信度 0.80
• Network analysis to understand gene regulation: across spatial scales and toward multi-level models.
  europepmc 2026 置信度 0.80
• Bridging Language Phenotypes, Neural Dynamics and Gene Regulation in Autism
  europepmc 2026 置信度 0.80
• Scalable and multiplexed recorders of gene regulation dynamics across weeks.
  europepmc 2026 置信度 0.80
• MORC-ALKBH1 antagonism shapes three-dimensional gene regulation in rice.
  europepmc 2026 置信度 0.80
• lncRNA CHASERR Integrates Transcriptional and Post-Transcriptional Gene Regulation
  europepmc 2025 置信度 0.80
• Correction: Functional phytochemicals in tomatoes: biosynthesis, gene regulation, and human health implications.
  europepmc 2026 置信度 0.80
• eRNAs modulate mRNA stability and translation efficiency to bridge transcriptional and post-transcriptional gene regulation.
  europepmc 2026 置信度 0.80
• Modeling rare melanoma subtypes: mechanisms, microenvironments and translational opportunities.
  Rare melanoma subtypes, such as uveal melanoma, desmoplastic melanoma, mucosal melanoma, and acral melanoma, account for about 10% of all melanomas and exhibit unique genetic backgrounds and immune microenvironments, leading to poor clinical prognosis. Due to …
  pubmed Meng Q, Yan F, You C, Xu R 等 2026 置信度 0.82
• Substrate-selective mTORC1 regulation and gene dosage-dependent tissue divergence in Birt-Hogg-Dubé syndrome.
  Birt-Hogg-Dubé (BHD) syndrome, caused by mutations in the tumor suppressor gene FLCN , has traditionally been classified as a classic "mTORopathy" characterized by global mTORC1 activation. Recent structural and multi-omic studies have fundamentally chall…
  pubmed Cao ZL, Zhao SC, Lin F, Liu YH 等 2026 置信度 0.82
• The role of OTUD1-mediated deubiquitination in disease pathogenesis: from molecular mechanisms to clinical translation.
  OTUD1 is a deubiquitinase of the OTU family that participates in immune signaling, redox balance, and cell death through modulating substrate ubiquitination. Under physiological conditions, OTUD1 primarily exerts negative regulatory effects, restricting excess…
  pubmed Wang Q, Zhang L, Cao H, Wang X 等 2026 置信度 0.82
• Endothelial Shear-Stress-Responsive Gene Adenylate Cyclase 4 Suppresses Atherosclerosis by Inhibiting cAMP/PKA-NF-κB Mediated Vascular Inflammation.
  Endothelial dysfunction is critical for the pathogenesis of atherosclerosis, particularly in arterial regions exposed to disturbed flow (DF). ADCY4 (adenylate cyclase 4) catalyzes the production of cAMP, a ubiquitous second messenger that regulates cellular an…
  pubmed Bao W, Xu J, Nian W, Pang P 等 2026 Aug 6 置信度 0.82
• TRPA1 Regulates Fibrosis-Associated Transcriptional Pathways in Human Lung Epithelial Cells.
  Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 …
  pubmed Halonen L, Luostarinen S, Valjus I, Vistbacka J 等 2026 Sep 置信度 0.82
• RIOK2 Promotes Clear Cell Renal Cell Carcinoma Progression Through Cell Cycle Regulation.
  Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer and is frequently associated with poor clinical outcomes. Ribosome biogenesis, which is upregulated in many malignancies, plays a key role in tumor proliferation. Right open…
  pubmed Shikuma H, Goto K, Shimo A, Hatayama T 等 2026 Aug 置信度 0.82
• Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen-Driven Autoimmunity.
  Citrullination and deamidation are post-translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate c…
  pubmed Callebaut A, Bruggeman Y, Mathieu C, James EA 等 2026 Aug 置信度 0.82
• Targeted Biospecimen Collection to Meet High Priority Pediatric Health Needs: The Developmental Genotype-Tissue Expression Project.
  The gene expression patterns that drive human development are not fully understood.
  pubmed Van Hoose PM, Linn RL, VonDran MW, Taylor D 等 2026 Aug 5 置信度 0.82
• Vascular smooth muscle cell FTO deletion aggravates atherosclerotic plaque instability by promoting VSMC migration through the N(6)-methyladenosine modification of the COL3A1 mRNA.
  Vascular smooth muscle cell (VSMC) migration is the key event in the pathogenesis of atherosclerosis (AS) and plaque instability. Trimethylamine-N-oxide (TMAO) induces VSMC migration to promote the progression of AS. However, the effects of the N 6 -methyladen…
  pubmed Yang Z, Deng K, Wu J, Wu N 等 2026 Aug 3 置信度 0.82
• Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour.
  Liver metastases are frequent and challenging to treat owing to the liver's metabolically active and immune-tolerant environment. However, how cancer cells exploit nutrient availability in the liver to evade immune surveillance remains unknown. Here we show th…
  pubmed Vandekeere A, Fernández-García J, Peng-Winkler Y, Martín Pérez M 等 2026 Aug 5 置信度 0.82
• Palmitoylation modulates neutrophil anti-tumour function in liver metastasis.
  pubmed Zhou L, Cui J 2026 Aug 5 置信度 0.82
• Experimental infection of acute bee paralysis virus induces differential responses of selected honey bee immune genes, independent of varroa resistance.
  Honeybees (Apis mellifera) have a complex immune system, with both innate and social immunity. The mite-resistant honeybee population from Gotland, Sweden, is well-known for their independent resistance to Varroa destructor mites and tolerance to virus infecti…
  pubmed Ruan X, Noël A, Thaduri S, de Miranda JR 等 2026 Aug 5 置信度 0.82
• Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1.
  RNA polymerase II (Pol II) is a 12-subunit enzyme crucial for gene transcription in the nucleus. However, its assembly in the cytoplasm, nuclear import, and nuclear function of assembly factors remain poorly understood. Here, we isolated Pol II from the cytopl…
  pubmed Schmitzová J, Zhan Y, Rengachari S, Grabbe F 等 2026 Aug 5 置信度 0.82
• Antagonistic regulation by mango MiSPL9a and MiSPL9b regulates flowering time, drought and salt stress in Arabidopsis.
  SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, which are unique to plants, contain a highly conserved SBP domain that regulates gene expression by binding to downstream targets. They play critical roles in various biological processes, esp…
  pubmed Meng Y, He X, He S, Li K 等 2026 Aug 5 置信度 0.82
• Comparative De Novo Transcriptomic Analysis of Leishmania tropica Provides Insights into Translation, Metabolism, and Virulence-Related Pathways Potentially Associated with Leishmania RNA Virus 2 Status.
  Leishmania tropica is an intracellular parasite belonging to the phylum Euglenozoa; it exhibits significant clinical heterogeneity and is spread by sandfly vectors through anthroponotic or zoonotic transmission. Leishmania RNA virus, a viral endosymbiont belon…
  pubmed Nalçaci M, Özbel Y, Mermer A, Töz S 2026 Aug 5 置信度 0.82
• OsHMGB1 functions as a transcriptional repressor of OsNRT2.2 in rice: Calcium-regulation and additive function with OsCCA1.
  Plant nitrogen uptake and utilization are governed by a complex network involving nitrate transporters and signal-responsive genes. Here, we show that the high mobility group box 1 protein OsHMGB1 directly binds to the OsNRT2.2 promoter and functions as a tran…
  pubmed Niu J, Guo Y, Cheng J, Ying S 等 2026 Aug 5 置信度 0.82
• The transcription factor DhDOF5 regulates mannose biosynthesis in Dendrobium huoshanense under low-temperature and water-deficit stress.
  Transcription factor proteins are important biological macromolecules that regulate plant metabolic pathways and stress responses. In Dendrobium huoshanense C. Z. Tang et S. J. Cheng, mannose biosynthesis is closely related to polysaccharide accumulation, howe…
  pubmed Wang C, Wang S, Guan J, Hao M 等 2026 Aug 5 置信度 0.82
• Alternative transcription of the mouse Gh gene identifies an immune-associated transcript with species-specific structural divergence.
  Growth hormone (GH) in mice is primarily expressed in the anterior pituitary, although Gh expression has been reported in extrapituitary tissues, including immune organs. However, the structure of immune-associated Gh transcripts remains poorly characterized. …
  pubmed Fukushima A, Takeuchi Y, Fukuchi H, Egoshi S 等 2026 Aug 5 置信度 0.82
• Multi-Omics Reveal Haplotype-Specific BGC Divergence and Organ-Specific Iridoid Glycoside Accumulation in Endemic Species Rehmannia chingii.
  Iridoid glycosides (IGs) are key bioactive metabolites within the genus Rehmannia. However, the molecular mechanisms underlying geographical and organ-specific divergence in IG accumulation, and the biosynthetic gene clusters (BGCs) between chromosomal haploty…
  pubmed Zhang W, Han Y, Jin X, Guo K 等 2026 Jul-Aug 置信度 0.82
• Variants leading to ELAVL2 haploinsufficiency cause a neurodevelopmental disorder with prominent cognitive, behavioral, and neurological features.
  RNA-binding proteins (RBPs) regulate gene expression, and a number of RBPs have been implicated in brain function and behavior. Here, we report 16 individuals with a neurodevelopmental disorder and de novo heterozygous variants in ELAVL2, encoding an RBP not p…
  pubmed Boon M, Mulligan MR, Verseput JJA, Šakić B 等 2026 Aug 5 置信度 0.82
• Integrated multi-omics and functional characterization reveal that COL6-mediated flavonoid metabolism contributes to drought tolerance in Juniperus sabina.
  Drought stress significantly constrains plant productivity in arid and semi-arid habitats. Understanding the molecular pathways of drought tolerance is essential for germplasm enhancement and ecological restoration. This study investigated the drought adaptati…
  pubmed Zhang XJ, Wang XH, Li R, Wang YF 等 2026 Aug 3 置信度 0.82
• Integrated assessment of biocontrol potential and genome analysis of endophytic Bacillus velezensis MGL-B1 against mango stem-end rot.
  Mango stem-end rot is a globally significant postharvest disease that severely threatens the mango industry, primarily caused by Botryosphaeria dothidea. However, information on biocontrol agents targeting this pathogen in mango remains limited. In this study,…
  pubmed Jian W, Yao Q, Zeng Y, Chen Y 等 2026 Jul 31 置信度 0.82
• Osthole and matrine suppress malignant progression of lead-exposed NSCLC via regulating cellular homeostasis: A combined network pharmacology and in vitro experimental study.
  Non-small cell lung cancer (NSCLC) is the predominant subtype of lung malignancy. Accumulating epidemiological evidence demonstrates that environmental lead (Pb) exposure as a critical driver of its initiation and progression.
  pubmed Xu Y, Dong J, Liu H, Zheng J 等 2026 Jul 30 置信度 0.82
• Characterization of the MLO gene family in Glycine max and its role in rust infection.
  The MLO gene family plays a critical role in plant-pathogen interactions, regulating susceptibility and resistance to fungal diseases. In this study, we performed a genome-wide characterization of the MLO genes in soybean ( Glycine max ), integrating structura…
  pubmed Ribeiro M, Oliveira L, Barbosa Avelino B, Abe V 等 2026 Jan 1 置信度 0.82
• Clinical Significance of SOX2 Promoter Methylation in Breast Cancer Prognosis.
  Introduction SOX2 , a key pluripotency gene, plays a central role in breast cancer stem cell (BCSC) biology, driving tumor aggressiveness. Although SOX2 dysregulation has been widely studied across various cancers, its specific regulatory mechanisms in breast …
  pubmed Maqbool F, Ahamed A, Anwar S, Fatima M 等 2026 Jan-Dec 置信度 0.82
• Early versus late JAK-STAT-IFN signaling distinguishes no rejection from subclinical to clinical TCMR after liver transplantation.
  Subclinical rejection after liver transplantation precludes immunosuppression withdrawal despite normal clinical function. To better understand the immunobiology of early subclinical rejection, we performed longitudinal, multimodal immune profiling and single-…
  pubmed Macedo C, Hadjiyannis Y, Tran LM, Elinoff BD 等 2026 Aug 5 置信度 0.82
• Early fate diversification of radial glial progenitors during corticogenesis.
  Radial glial progenitors (RGPs) generate all projection neurons (PNs) in the cerebral cortex through incompletely understood processes. We combined Mosaic Analysis with Double Markers at embryonic stages (E)12.5 and E13.5 with early postnatal callosal tracing …
  pubmed Varela-Martínez I, Villalba A, García-Marqués J, Aguilera A 等 2026 Aug 7 置信度 0.82
• Cohesin facilitates nucleosome invasion by transcription factors.
  Nucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs known as pioneer factors (PFs) can recognize motifs covered by nucleosomes and initiate chromatin opening. PFs also bind nucleosomal substrates with high affin…
  pubmed Stoeber S, Chen H, Chen RW, Smith C 等 2026 Aug 7 置信度 0.82
• Vimentin remodeling in response to oxidants and electrophiles is modulated by pH.
  Vimentin is critical for cell mechanosensing, cytoskeletal cross-talk, and stress responses and is finely tuned by posttranslational modifications. Vimentin single cysteine, C328, is a modification hotspot, essential for filament remodeling by oxidants and ele…
  pubmed Martínez AE, Martínez-Cenalmor P, González-Jiménez P, Vidal-Verdú C 等 2026 Aug 7 置信度 0.82
• Unveiling previously undescribed circadian clock regulators and action mechanisms via TurboID-based profiling of the LWD1 interactome in Arabidopsis thaliana.
  The synchronization of the internal circadian clock with the external 24-h diel cycle is critical for plant growth and fitness. LIGHT-REGULATED WD proteins (LWDs) are essential for sustaining a precise and robust circadian clock in Arabidopsis [Y. Wang et al. …
  pubmed Huang CK, Hsu CC, Tsai HL, Lin WD 等 2026 Aug 11 置信度 0.82
• Systematic profiling of nudivirus-like genes reveals conserved and differentiated roles in a domesticated endogenous virus.
  Cotesia vestalis bracovirus (CvBV) is a type of domesticated endogenous virus (DEV) derived from ancestral nudiviruses that is integrated into the genome of the parasitoid wasp Cotesia vestalis. The CvBV proviral genome is composed of two distinct components: …
  pubmed Zhou Y, Ding K, Zhang S, Yang X 等 2026 Aug 5 置信度 0.82
• Advancements in the role of RPD3-type histone deacetylases in plant development and stress responses.
  Plants have evolved dynamic and complex epigenetics-dependent mechanisms to ensure sustainable growth and development under various environmental circumstances. Histone acetylation is a post-translational modification (PTMs) important in controlling reversible…
  pubmed Bajpai SK, Nisha, Dwivedi R, Verma PC 2026 Jul 置信度 0.82
• Neddylation pathway promotes the ubiquitinated degradation of FBXO21 in lung cancer cells.
  SCF (Skp1-Cullin1-Fbox protein) is a multi-subunit RING-type E3 ligase and plays critical roles in various pivotal physiological and pathological processes by mediating the ubiquitination and degradation of key proteins. F-box proteins directly bind substrates…
  pubmed Zhang Y, Li M, Dong T, Zhou Y 等 2026 Jul 7 置信度 0.82
• Ion-Driven Regulation of Ca(2) (+) Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage-Mediated Bone Regeneration.
  The field of tissue engineering is transitioning from bioinert to bioactive materials that actively regulate host biology. Here, we developed a 3D-printed porous Ti scaffold infiltrated with molten Zn to form an interpenetrating Ti/Zn composite with immunomodu…
  pubmed Huang W, Zhang Q, Qiu Y, Suo H 等 2026 Aug 5 置信度 0.82