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This study examines how testosterone levels and kisspeptin gene expression are affected in male Syrian hamsters following pinealectomy and photoperiod modification. By examining the rhythmic changes in these parameters under long (16L: 8D) and short (8L: 16D) …
pubmed
Balkan Eİ, Gündüz B
2026 Aug
置信度 0.82
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Paqr7 and paqr8 are genes encoding membrane progestin receptor αand β (mPRα and mPRβ, respectively), which are currently classified as members of the progestin and adipoQ receptor (PAQR) family. For mPRα, the first identified mPR …
pubmed
Farid MA, Tanvir MR, Mouri T, Tsutsumi E 等
2026 Aug
置信度 0.82
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Tendon injuries in humans often lead to significant functional impairments, necessitating effective regeneration methods. While mammalian tendon healing typically results in scar formation and functional loss, certain species such as axolotls exhibit remarkabl…
pubmed
Amada R, Yamamoto S, Ohashi A, Nakayama H 等
2026 Aug
置信度 0.82
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Immune checkpoint blockade (ICB) can produce durable responses in cancer, but reliable predictors of benefit are still lacking. CD8 + tumor-specific T cells (TSTs) are essential for ICB efficacy, yet it remains unclear which functional states of these cells ar…
pubmed
Cao S, Cheng J, Wang FA, Yi C 等
2026 Aug 5
置信度 0.82
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While exercise training is an established cornerstone for the prevention and treatment of cardiovascular diseases (CVDs), the underlying molecular mechanisms remain incompletely understood. Recent studies have identified long non-coding RNAs (lncRNAs) as criti…
pubmed
Gao T, Yu LH
2026 Aug 5
置信度 0.82
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During heart failure (HF), gene and protein expression profiles undergo extensive compensatory and pathological remodeling. We previously observed that fast skeletal myosin binding protein-C (fMyBP-C) is upregulated in diseased mouse hearts. While fMyBP-C shar…
pubmed
McNamara JW, Song T, Alam P, Baby A 等
2026 Aug 5
置信度 0.82
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Salt stress disrupts photosynthesis, ion homeostasis, and antioxidant systems, thereby inhibiting plant growth and reducing the yield and quality. This study investigated the physiological and molecular mechanisms of salt stress alleviation by foliar applicati…
pubmed
Zhou X, Yu W, Cui Y, Meng X 等
2026 Aug 5
置信度 0.82
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Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by widespread dysregulation of gene expression and regulatory pathways. MicroRNAs (miRNAs) act as key post-transcriptional regulators by modulating messenger RNAs (mRNAs), and their…
pubmed
Ray A, Agarwal K, Jha S, Singh AM 等
2026 Aug 5
置信度 0.82
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NnARF9 directly represses NnSUS2 transcription via TGTCTC motif binding, inhibiting sucrose cleavage; NAA activates this pathway to boost sucrose storage in photosynthetic tissues. Sucrose is the most common type of sugar produced in photosynthetic organs and …
pubmed
Wu P, Guo Y, Ling W, Qu C 等
2026 Aug 5
置信度 0.82
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Historical famine exposure has left enduring biological imprints that continue to shape health outcomes in modern environments characterized by nutritional abundance. This study examines the epigenetic legacies of famine, focusing on mechanistic pathways that …
pubmed
Neamah AS, Al-Rikabi RH, Lafta FM
2026 Aug 5
置信度 0.82
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6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is a key glycolytic regulator involved in the compensation for β-cell dysfunction under diabetic conditions, but its upstream regulation is incompletely understood. Here, we have characterize…
pubmed
Izumihara R, Nomoto H, Chiba K, Kameda H 等
2026 Aug 5
置信度 0.82
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The primitive endoderm (PE), or hypoblast in humans, is a conserved extra-embryonic lineage essential for mammalian development that fulfills key roles in embryo patterning, such as contributing to the gut endoderm, providing nutrient and gas exchange, and hos…
pubmed
Kim-Yip RP, Faerberg DF, Posfai E
2026 Aug 1
置信度 0.82
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Catheter-associated urinary tract infections (CAUTIs) are one of the most common hospital-associated infections in the United States, accounting for >1 million cases annually. One CAUTI pathogen, Staphylococcus aureus , is commonly found persisting asymptom…
pubmed
Gomez J, Duran-Ramirez J, Alvarez M, Cristy S 等
2026 Aug 5
置信度 0.82
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In most Bacillus thuringiensi s strains, the cry genes are transcribed by RNA polymerases containing sporulation-sigma factors E or K, leading to the formation of an insecticidal crystal within the mother cell along spore development. The kurstaki HD1 strain, …
pubmed
Verplaetse E, Nevers A, Slamti L, Lereclus D
2026 Aug 5
置信度 0.82
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The MgtC virulence factor is important during the intramacrophage stage in both classical intracellular pathogens, such as Salmonella Typhimurium, and in extracellular bacteria that transiently encounter intracellular environments during infection, such as Pse…
pubmed
Bonhoure A, Nogaret P, Perez V, Nilly F 等
2026 Aug 5
置信度 0.82
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Evolutionary constraints governing flagellar number in bacterial pathogens remain poorly understood. While related Pseudomonas species are hyperflagellated, Pseudomonas aeruginosa maintains strict monoflagellation through the FleQ-FleN regulatory circuit. Here…
pubmed
Migueles-Lozano A, Asp M, Rocha ST, Li J 等
2026 Aug 5
置信度 0.82
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Alzheimer's disease (AD) arises from heterogeneous biological processes, and long-term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.
pubmed
Kim BH, Lee H, Kim J, Seo SW 等
2026 Aug
置信度 0.82
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Intestinal epithelial cells play a crucial role in teleost defence against complex aquatic environments. However, the study of intestinal mucosal immunity in teleosts has been hindered by the lack of reliable and specific marker genes to distinguish between di…
pubmed
Xue T, Wang Y, Su B, Cao M 等
2026 Aug 5
置信度 0.82
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Ichang papeda ( Citrus ichangensis ), a wild primitive citrus species, exhibits remarkable cold tolerance, yet the transcriptional regulation of cold-responsive genes in C. ichangensis remains poorly explored. In this study, we identified the small heat shock …
pubmed
Zeng X, Chu L, Hu W, Wang Y 等
2026 Aug
置信度 0.82
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Intermittent fasting (IF) is a dietary intervention known to promote systemic health benefits, yet its impact on genome-wide transcriptional regulatory networks, particularly those involving transposable elements (TEs), remains poorly understood. This study in…
pubmed
Cheng X, Fan Y, Peng X, Tabassum NI 等
2026 Aug
置信度 0.82
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The multidrug-resistant pathogen Clostridioides difficile ( C. difficile ) presents a persistent clinical threat. While Multidrug and Toxic Compound Extrusion (MATE) transporters are recognized as xenobiotic efflux pumps, their pleiotropic roles in pathogen ph…
pubmed
Deng J, Chen FH, Wu WJ, Huang TY 等
2026
置信度 0.82
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Colorectal cancer (CRC) remains a global health challenge with rising incidence in younger populations and limited efficacy of current chemotherapies. In this study, we investigated the anti-tumor mechanisms of metochalcone (MET), a natural chalcone derivative…
pubmed
Chen P, An J, Han M, Wang Y 等
2026
置信度 0.82
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Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon characterized by severe disease burden and multiple co-morbidities. Currently, the endoscopic Mayo score is considered the gold standard for assessing disease severity in UC. Ho…
pubmed
Ozcariz E, Ostaszewski M, Lopata O, Ciglar L 等
2026
置信度 0.82
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West Nile virus (WNV)-associated neurological diseases pose a global public health burden, yet no approved antiviral treatments are available. This is primarily due to the challenges of crossing the blood-brain barrier and the lengthy, costly process of drug d…
pubmed
Xia L, Luo Z, He Y, Peng H 等
2026
置信度 0.82
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Hyperthermia is a potential therapy for non-small cell lung cancer (NSCLC); however, cell resistance to hyperthermia remains challenging. This study investigated the role of heat shock protein 70 (HSP70) in regulating small ubiquitin-like modifier modification…
pubmed
Wan J, Peng B, Ling X, Wang X
2026
置信度 0.82
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One of the key regulatory mechanisms in adipose biology is the NAD + /SIRT axis, which is disrupted in conditions such as obesity and insulin resistance. In recent years, increasing attention has been directed toward understanding the role of NAD + in adipose …
pubmed
Postolov F, Milenkovic D, Ruskovska T
2026
置信度 0.82
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In natural and agricultural ecosystems, nitrogen deficiency is often a major limiting factor for plant growth, while research on the molecular genetic basis of nitrogen uptake and utilization in slash pine remains scarce. This study explored the regulatory mec…
pubmed
Wu S, Ding X, Luan Q, Hua X 等
2026
置信度 0.82
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B-cell precursor acute lymphoblastic leukemia (preB-ALL) is characterized by pathogenic variants currently used in precision oncology. However, the mutational landscape of Mexican children with preB-ALL has not yet been thoroughly explored and defined in terms…
pubmed
Martínez Anaya D, Juárez-Velázquez MDR, Juárez Figueroa U, Dean M 等
2026 Sep
置信度 0.82
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Drought is a major environmental constraint on crop growth, development, and yield. Xyloglucan endotransglucosylase/hydrolases (XTHs) have been reported to play important roles in plant drought tolerance. We previously identified the cold-responsive tomato gen…
pubmed
Liu T, Dong L, Lu K, Xu D 等
2026 Jul-Aug
置信度 0.82
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Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by anxiety, abnormal stress responses, and pathological memory formation. Research indicates that hypoxia-inducible pathways might influence the neurobiology of PTSD. However, the sp…
pubmed
Porkhalo D, Pashevin D, Naumenko Y, Dosenko V
2026 Aug
置信度 0.82
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Epigenetics, the study of heritable changes in gene expression that occur without altering the underlying DNA sequence, has emerged as an important conceptual framework for anesthesiology. The epigenome is organized into three mechanistic tiers: cytosine methy…
pubmed
Byon HJ
2026 Jul
置信度 0.82
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Sucrose transport and starch accumulation are crucial carbohydrate metabolic processes in rice, playing essential roles during late pollen development to ensure pollen maturation, fertility and high grain production. However, the molecular mechanisms regulatin…
pubmed
Li Q, Zhang C, Wang S, Chen J 等
2026 Aug 4
置信度 0.82
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Mixed-linkage β-glucans (MLGs) are emerging as promising biopolymers with significant biotechnological potential due to their unique structural and rheological properties. In rhizobia, MLG biosynthesis is controlled by the second messenger cyclic di-GMP …
pubmed
Ruiz-Sáez L, Pacheco PJ, Peinado J, Lloret J 等
2026 Aug
置信度 0.82
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In teleosts, insulin-like growth factor binding protein-2b (IGFBP-2b) is the major carrier of serum insulin-like growth factor (IGF). A line of gene edited rainbow trout (2bKO) was produced that lack a functional IGFBP-2b and associated phenotypes of reduced s…
pubmed
Cleveland BM, Radler L, Shimizu M
2026 Aug 4
置信度 0.82
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Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas and the most common cause of disease-associated death for neurofibromatosis type 1 (NF1) patients. In the context of NF1, MPNSTs develop from benign premalignant precursors a…
pubmed
Stahl MR, Stehn CM, Seeman ZJ, Faulk C 等
2026 Aug
置信度 0.82
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Rho related BTB domain containing 1 (RhoBTB1) is highly expressed in placenta and functions to deliver protein targets to the Cullin-3 (CUL3) E3 ubiquitin ligase where they are targeted for ubiquitination and degradation. The targets of RhoBTB1 in placenta hav…
pubmed
Tvina AL, Livergood MC, Kumar G, Hole VW 等
2026 Aug
置信度 0.82
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Cerebral ischemia-reperfusion injury (CIRI) is a severe neurological condition. LncRNA-XIST is closely associated with CIRI; however, its underlying mechanism remains unclear. A middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and an oxygen-gluc…
pubmed
Lu X, Chen L, Qian L, Zhang X 等
2026 Aug
置信度 0.82
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Post-translational modifications (PTMs) can generate neo-epitopes, modified peptides that evade immune tolerance and trigger immune responses. This review focuses on the TG2/LRP1 pathway as a new paradigm for coupling the formation of post-translationally modi…
pubmed
Sewa AS, Yang FC, Khosla C
2026 Aug
置信度 0.82
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Seed dormancy and germination are tightly regulated by complex signaling networks that integrate internal and external cues, including the endogenous phytohormone abscisic acid (ABA). ABA HYPERSENSITIVE GERMINATION 1 (AHG1), a group A type 2C protein phosphata…
pubmed
Nishimura N, Ushiyama S, Otagiri M, Satoh K 等
2026 Aug
置信度 0.82
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Streptococcus mutans is considered the key contributor to human dental caries. The LuxS/AI-2 quorum‑sensing (QS) system in S. mutans plays a crucial role in the development of cariogenic oral biofilms. Many QS systems rely on regulation carried out by s…
pubmed
Mao MY, Liang YJ, Chen JX, Zhang YJ 等
2026 Dec
置信度 0.82
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Low-birth-weight (LBW) piglets often exhibit glycolipid metabolic disorders at birth, which severely impair their postnatal growth and survival. Bile acids (BAs) act as signaling molecules that participate in the regulation of glycolipid metabolism. However, w…
pubmed
Gao T, Liang H, Li M, Zhou R 等
2026 Aug 5
置信度 0.82
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Phosphorus (P) deficiency in the soil significantly limits pecan growth due to its low availability and mobility. However, the molecular mechanisms underlying these responses to P deficiency are unclear. Therefore, this study aimed to describe adaptive strateg…
pubmed
Qian S, Xu J, Shen X, Wang S 等
2026 Aug 5
置信度 0.82
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Drug addiction is characterized by orchestrated transcriptional changes in brain reward regions, including the nucleus accumbens (NAc). The transcription factor E2F3a has emerged as a novel regulator of cocaine's rewarding effects, yet its sex- and cell-specif…
pubmed
Martínez-Rivera FJ, Yim YY, Holt LM, Godino A 等
2026 Aug 4
置信度 0.82
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Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4 + T helper lineage but lack antigen receptors. Type 3 ILCs (ILC3s) are enriched at barrier sites, regulating inflammation and promoting tissue integrity. He…
pubmed
Malysheva V, Ray-Jones H, Lakes N, Brown RA 等
2026 Aug 4
置信度 0.82
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europepmc
2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2026
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2025
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2025
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2025
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2025
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2025
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2025
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2026
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2025
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europepmc
2024
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2025
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2025
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2025
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2024
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2025
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