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• Evaluation of CRISPR gene-editing tools in zebrafish.
  europepmc 2022 置信度 0.80
• CRISPR gene editing - what are the possibilities for respiratory medicine?
  europepmc 2022 置信度 0.80
• DIPA-CRISPR gene editing in the yellow fever mosquito <i>Aedes aegypti</i> (Diptera: Culicidae)
  europepmc 2023 置信度 0.80
• CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis.
  europepmc 2022 置信度 0.80
• Commentary: CRISPR gene editing for inherited retinal dystrophies: Towards clinical translation.
  europepmc 2022 置信度 0.80
• Advances in Delivery Mechanisms of CRISPR Gene-Editing Reagents in Plants.
  Gene-editing by CRISPR/Cas systems has revolutionized plant biology by serving as a functional genomics tool. It has tremendously advanced plant breeding and crop improvement by accelerating the development of improved cultivars, creating genetic variability, …
  europepmc Larissa C. Laforest, Satya Swathi Nadakuduti 2022 置信度 0.80
• CRISPR Gene Editing in Lipid Disorders and Atherosclerosis: Mechanisms and Opportunities.
  europepmc 2021 置信度 0.80
• HIF1A Knockout by Biallelic and Selection-Free CRISPR Gene Editing in Human Primary Endothelial Cells with Ribonucleoprotein Complexes.
  europepmc 2022 置信度 0.80
• CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy.
  europepmc 2022 置信度 0.80
• Recent Scientific Breakthroughs Applying CRISPR Gene Editing in Neurological Disorders.
  europepmc 2021 置信度 0.80
• Visualization Analysis of CRISPR Gene-editing Knowledge Map based on Citespace.
  europepmc 2021 置信度 0.80
• Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase.
  europepmc 2022 置信度 0.80
• Dissection of the epoxyjanthitrem pathway in <i>Epichloë</i> sp. <i>Lp</i>TG-3 strain AR37 by CRISPR gene editing.
  europepmc 2022 置信度 0.80
• A Decade of CRISPR Gene Editing in China and Beyond: A Scientometric Landscape.
  Since its Nobel Prize-winning breakthrough in 2012, CRISPR-Cas-based gene-editing system has emerged as one of the most promising biotechnologies in decades. In this article, we present an objective and comprehensive evaluation of CRISPR-based gene-editing tec…
  europepmc Wuyuan Zhou, Yajun Yuan, Yaqun Zhang, Deng Chen 2021 置信度 0.80
• CRISPR gene editing of major domestication traits accelerating breeding for Solanaceae crops improvement.
  europepmc 2022 置信度 0.80
• Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing.
  europepmc 2022 置信度 0.80
• Shining Light on CRISPR Gene Editing.
  europepmc 2020 置信度 0.80
• High-efficiency CRISPR gene editing in C. elegans using Cas9 integrated into the genome.
  europepmc 2021 置信度 0.80
• Correction of muscular dystrophies by CRISPR gene editing.
  europepmc 2020 置信度 0.80
• Functional validation of variants of unknown significance using CRISPR gene editing and transcriptomics: A Kleefstra syndrome case study.
  europepmc 2022 置信度 0.80
• Pioneers of revolutionary CRISPR gene editing win chemistry Nobel.
  europepmc 2020 置信度 0.80
• Pupal and Adult Injections for RNAi and CRISPR Gene Editing in Nasonia vitripennis.
  europepmc 2020 置信度 0.80
• CRISPR Gene-Editing Models Geared Toward Therapy for Hereditary and Developmental Neurological Disorders.
  europepmc 2021 置信度 0.80
• CRISPR gene editing in human embryos wreaks chromosomal mayhem.
  europepmc 2020 置信度 0.80
• High-efficiency CRISPR gene editing in <i>C. elegans</i> using Cas9 integrated into the genome
  europepmc 2021 置信度 0.80
• CRISPR gene editing in pluripotent stem cells reveals the function of MBNL proteins during human in vitro myogenesis.
  europepmc 2021 置信度 0.80
• Include egg donors in CRISPR gene-editing debate.
  europepmc 2019 置信度 0.80
• Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm.
  europepmc 2021 置信度 0.80
• One Small Dose, One Giant Leap for CRISPR Gene Editing.
  europepmc Alex Philippidis 2020 置信度 0.80
• Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants.
  europepmc 2021 置信度 0.80
• Reply to: Atomic bomb and CRISPR gene editing technology.
  europepmc 2019 置信度 0.80
• CRISPR Gene Editing in the Kidney.
  europepmc 2018 置信度 0.80
• Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemia
  europepmc 2020 置信度 0.80
• CasX: a new and small CRISPR gene-editing protein.
  europepmc 2019 置信度 0.80
• Data Mining by Pluralistic Approach on CRISPR Gene Editing in Plants.
  europepmc 2019 置信度 0.80
• RNA silencing suppressor-influenced performance of a virus vector delivering both guide RNA and Cas9 for CRISPR gene editing.
  europepmc 2021 置信度 0.80
• Shaping the CRISPR Gene-Editing Debate: Questions About Enhancement and Germline Modification.
  europepmc 2020 置信度 0.80
• RNA-Seq Analysis Reveals CCR5 as a Key Target for CRISPR Gene Editing to Regulate In Vivo NK Cell Trafficking.
  europepmc 2021 置信度 0.80
• LION: a simple and rapid method to achieve CRISPR gene editing.
  europepmc 2019 置信度 0.80
• CRISPR gene-editing creates wave of exotic model organisms.
  europepmc Sara Reardon 2019 置信度 0.80
• Transcriptome Profiling of <i>Ornithogalum dubium</i> Leaves and Flowers to Identify Key Carotenoid Genes for CRISPR Gene Editing.
  europepmc 2020 置信度 0.80
• A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing.
  europepmc 2020 置信度 0.80
• Microbial single-strand annealing proteins enable CRISPR gene-editing tools with improved knock-in efficiencies and reduced off-target effects.
  europepmc 2021 置信度 0.80
• A natural Nlscarlet insertion underlies the orange-eye phenotype and facilitates efficient multiple-sgRNA genome editing in Nilaparvata lugens.
  Eye-color mutants provide easily distinguishable visual markers for genetic analysis and genome editing, yet the molecular basis of naturally occurring eye-color variation in Nilaparvata lugens remains unclear. Here, we combined classical genetic analysis, can…
  pubmed Ye WN, Chen RY, Xing Q, Zhang YC 等 2026 Aug 5 置信度 0.82
• A scoping review of gene editing in clinical trials: identifying aspects of trial design to accelerate clinical adoption.
  Initial clinical trials of gene editing have recently emerged and generated significant interest in this promising therapy. A scoping review is needed to understand aspects of study design that may accelerate further clinical translation.
  pubmed Khare G, Duong A, Hanotaux J, Shorr R 等 2026 Apr 23 置信度 0.82
• CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat β-Thalassemia.
  pubmed 2026 Aug 6 置信度 0.82
• CRISPR/Cas system as a novel therapeutic strategy to combat multi-drug-resistant bacteria.
  Antimicrobial resistance (AMR) has diminished the effectiveness of present antibiotics, posing a huge threat to global community health and economic stability. This study investigates the CRISPR-Cas framework's potential as a cutting-edge tactic to fight antim…
  pubmed Zubair A, Hemal MAKP, Ahmed A, Ahmad F 等 2026 Aug 5 置信度 0.82
• CCDC149: a novel gene associated with hypopituitarism and neurodevelopmental impairment.
  Congenital Hypopituitarism (CH) is a complex developmental disorder characterized by variable pituitary dysfunction that is often associated with midline structural abnormalities that affect the brain, eyes and face. To date, only &#x223c;10-15% of patients ha…
  pubmed Gregory LC, Rath S, Mandel H, Assad GE 等 2026 Aug 5 置信度 0.82
• Nitro Reduction-Based RNA Control and Ultrafast Release.
  RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post-synthetic RNA modification strategies remains a significant challenge. Here, we introdu…
  pubmed Zhao Y, Zhang S, Guo J, Kha TK 等 2026 Aug 5 置信度 0.82
• Targeted Genetic Knockout of Can f 1, the Major Allergen in Dogs.
  Dog allergy is a prevalent IgE-mediated condition, with the salivary lipocalin Can f 1 accounting for the majority of dog-specific IgE reactivity in sensitized individuals. Existing strategies for managing dog allergy primarily rely on modulating host immune r…
  pubmed Walker MWG, Margolis C, Wiegand T, Gavin N 等 2026 Aug 5 置信度 0.82
• Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control.
  Recombinant herpesvirus vectors have emerged as highly potent platforms for next-generation vaccine development, distinguished by their genomic capacity and their unique ability to elicit durable, long-lasting immunity through persistent latent infections. In …
  pubmed Guo J, Mei C, Sun X, Lin Q 等 2026 置信度 0.82
• CRISPR/Cas9-based gene-editing platform development by targeting genes encoding magnesium chelatase and phytoene desaturase in sugarbeet (Beta vulgaris L.).
  Sugarbeet ( Beta vulgaris ssp. vulgaris , L.), is a vital temperate crop, supplying nearly 40% of the world's sugar. However, its high susceptibility to bacterial, fungal, and viral diseases creates an urgent need for improved, disease-resistant cultivars. The…
  pubmed Khan ZA, Hathaway T, Chu C, Gupta R 等 2026 置信度 0.82
• Human Embryonic Stem Cell-Derived Immunity-And-Matrix-Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1-Mediated Collagen Degradation.
  Currently, no targeted therapy exists for idiopathic pulmonary fibrosis (IPF). The hallmark pathological feature of excessive extracellular matrix (ECM) deposition severely undermines the efficacy of mesenchymal stem cell (MSC)-based treatments. While existing…
  pubmed Li Z, Song D, Sun F, Song L 等 2026 Aug 5 置信度 0.82
• CRISPR-Cas Systems as Precision Antimicrobials: Reversing the Tide of Antimicrobial Resistance.
  Antimicrobial resistance (AMR) has escalated into a global health crisis, with resistant pathogens causing over 1.2 million direct deaths annually and threatening to render modern medicine unsustainable. This review provides a comprehensive and updated synthes…
  pubmed Khosrojerdi M, Hashemi SA, Besharati R, Haghbin A 等 2026 Aug 4 置信度 0.82
• Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.
  Germline gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) gene cause a dominantly inherited inborn error of immunity (IEI) characterized by chronic mucocutaneous candidiasis, autoimmunity, severe opportunistic …
  pubmed Torrance R, Orf K, White N, Matti C 等 2026 Aug 4 置信度 0.82
• [Current and future therapies for bradykinin-mediated angioedema].
  Bradykinin-mediated angioedema, particularly hereditary angioedema due to C1 esterase inhibitor deficiency or dysfunction (HAE-C1INH), is caused by dysregulation of the kallikrein-kinin system with excessive bradykinin generation and subsequent increased vascu…
  pubmed Fasshauer M, Dominas N 2026 Aug 4 置信度 0.82
• CRISPR/Cas9-edited organoids as a platform for tailored research of colorectal cancer.
  Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Mortality rates and limited therapeutic options justify the development of reliable preclinical research models, as their translational value remains limited. Simple in vitro models do …
  pubmed Mojzesova N, Hladikova P, Kozovska Z, Poturnajova M 等 2026 Aug 4 置信度 0.82
• BASELINE: a CRISPR base editing platform for mammalian-scale single-cell lineage tracing.
  A cell's fate is shaped by its inherited state, or lineage, and the ever-shifting context of its environment. CRISPR-based recording technologies are a promising solution for mapping the lineage of a developing system; however, challenges remain regarding sing…
  pubmed Winter E, Emiliani F, Cook A, Abderrahim A 等 2026 Jul 17 置信度 0.82
• Cas-regulation-targeting chimera enables selective and tunable control of CRISPR/Cas12a.
  Selective and tunable regulation of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a activity enables on-demand control, yet current strategies remain hindered by nonspecific regulation and limited tunability. Inspired by proximity eff…
  pubmed Li Y, Han P, Yuan R, Bai L 等 2026 Jul 17 置信度 0.82
• The PtARF6/PtARF8-PtGH3.1 transcriptional module regulates auxin homeostasis and dwarfism in citrus.
  Dwarfing rootstocks are crucial for high-density and labor-efficient citrus cultivation, yet the molecular mechanisms underlying plant height regulation remain poorly understood. Using an integrated multi-omics analysis of dwarf and normal-height red tangerine…
  pubmed Chen S, Fan Z, Peng J, Zheng H 等 2026 Aug 4 置信度 0.82
• A Digital Microfluidic Electroporation Platform for Low-input CRISPR Genome Editing and mRNA Transfection In Suspension T Cells and 3D Cell Models.
  Digital microfluidic (DMF) electroporation enables precise, low-volume genetic manipulation of mammalian cells while minimizing cellular input by up to 100x and preserving viability. This study presents a high-throughput DMF-based transfection workflow for CRI…
  pubmed Patel MA, Singh M, Sinha H, Vo PQN 等 2026 Jul 17 置信度 0.82
• A Reproducible Electroporation Strategy for CRISPR-Cas9 RNP and mRNA Delivery in Fish Embryos.
  This study presents a streamlined electroporation-based method for efficient macromolecular delivery into zebrafish embryos. We first characterized the physical barrier posed by the chorion using TEM (Transmission Electron Microscope) and established that its …
  pubmed Hu Y, Fang F, Cui Z, Chen S 2026 Aug 3 置信度 0.82
• Recent advances in biomarkers, artificial intelligence, and targeted therapeutic strategies in breast cancer: Current progress and future perspectives.
  Breast cancer is a complex and heterogeneous disease that remains a major global health challenge. Recent progress in molecular biology, artificial intelligence (AI), and precision medicine has transformed its diagnosis and treatment. Conventional biomarkers s…
  pubmed Sharma D, Bhardwaj P, Mishra KK, Mishra N 等 2026 Jul 31 置信度 0.82
• Nonhuman Primate Genomes Have Limited Relevance for Evaluating Human CRISPR Off-Target Effects.
  Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has revolutionized genetic medicine by enabling precise genome editing for therapeutic benefit. CRISPR nucleases are programmed to target genomic sites with sequence complementarity …
  pubmed Blaha L, Bosinger M, Bodian DL, Qu V 等 2026 Aug 1 置信度 0.82
• Parahenipavirus langyaense (Langya virus): Spillover ecology, noncanonical receptor-mediated entry, and future control strategies.
  Langya virus (LayV), classified in the species Parahenipavirus langyaense , is a newly identified zoonotic paramyxovirus discovered in febrile patients in eastern China in recent years. The discovery of LayV has expanded the field beyond the prevailing paradig…
  pubmed Shen L, Tong Y, Chai W, Sun J 等 2026 Dec 置信度 0.82
• EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing.
  Allele-specific CRISPR/Cas editing is a powerful tool with great potential for treating genetic diseases and for uncovering the effects of allelic diversity. By targeting commonly inherited single nucleotide polymorphisms (SNPs), a small number of gRNAs can tr…
  pubmed Saxena AG, Ramey GD, Capra JA, Conklin BR 等 2026 Jul 24 置信度 0.82
• Host-Informed Engineering of Glycosylation in Komagataella phaffii for Human Biantennary N-Linked Glycans.
  Komagataella phaffii is a common alternative host to mammalian cell lines for heterologous production of recombinant proteins due to its cost-effectiveness and accelerated development. Its native N-linked glycosylation, however, yields high-mannose structures …
  pubmed Yang Y, Naranjo CA, Dalvie NC, Hinckley JA 等 2026 Jul 20 置信度 0.82
• Generation of ANP- and BNP-deficient human iPSC-derived cardiomyocytes reveals natriuretic peptide-dependent Angiogenic paracrine effects.
  Cell therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has emerged as a promising strategy for cardiac regeneration. Although transplanted PSC-CMs can contribute to remuscularization, accumulating evidence suggests that paracrine mechanisms …
  pubmed Yang X, Shiba N, Kadota S, Zhao J 等 2026 Jul 31 置信度 0.82
• Enhanced replication and immunogenicity of a genome-modified non-replicating vaccinia virus Tiantan strain for robust low-dose protection in mice.
  A non-replicating Tiantan strain-based vaccinia virus (NTV) holds significant application prospects for vaccination and gene therapy and has recently entered clinical trials as a novel and safer vaccine candidate against monkeypox. However, optimization is sti…
  pubmed Ren J, Liu S, Yuan H, Wu Y 等 2026 Jul 31 置信度 0.82
• Tiny but powerful: protoplast isolation in Solanum melongena L. and RNPs mediated genome editing.
  Traditional genetic transformation approaches relying on Agrobacterium tumefaciens for the delivery of CRISPR/Cas9 reagents usually provide plants that stably integrate the gene construct in their genome. To meet the EU commission's proposal for a new legislat…
  pubmed Ferrero M, González MN, Perrone I, Hofvander P 等 2026 置信度 0.82
• AI-enhanced framework for optimizing CRISPR-Cas gene editing in crop biotechnology addressing regulatory challenges and opportunities in global agricultural practices.
  The integration of CRISPR Cas genome editing with artificial intelligence (AI) offers significant potential for crop biotechnology by supporting more precise and adaptive strategies for trait improvement under complex agricultural and regulatory conditions. Ho…
  pubmed Zhu L, Huang J, Xie C 2026 置信度 0.82
• The WD40 repeat protein OsDPMS1 controls pistil development and female fertility in rice.
  The pistil, a key female reproductive organ in flowering plants, plays a critical role in sexual reproduction. Although pistil function has been well studied in some species, the molecular mechanisms governing its development in rice (Oryza sativa) remain uncl…
  pubmed Li JL, Wu YZ, Huang FJ, Yao HW 等 2026 Jul 30 置信度 0.82
• Pectinase-Based Bioprocesses for Circular Bioeconomy and Sustainable Industrial Development.
  Pectinases play a vital role in the degradation of pectic part of the plant cell wall and are considered in the group of hydrolytic enzymes. In the present scenario, demand of economically feasible and environment friendly techniques and approaches has signifi…
  pubmed Sharma N, Tanwar D, Grewal U, Keerthi MM 等 2026 Jul 30 置信度 0.82
• Modeling myeloid cell development in health and disease using induced pluripotent stem cells.
  The pioneering discovery by Yamanaka and colleagues enabling the reprogramming of terminally differentiated somatic cells into induced pluripotent stem cells (iPSCs) has opened transformative opportunities for disease modeling and regenerative medicine, partic…
  pubmed Tesakov I, Nasri M, Klimiankou M, Findik B 等 2026 置信度 0.82
• Patient-Derived Organoid-Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges.
  Patient-derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR-based perturbation technologies have transfo…
  pubmed du Plessis J, Omar A 2026 Aug 置信度 0.82
• A Helicase-Fused Cas9 improves Large-Size Fragment Knock-in.
  Homologous recombination (HR) mediated large-size fragment knock-in (ls-KI) remains inefficient in mammalian cells, even with the assistance of CRISPR/Cas9. We hypothesized that adding DNA helicase activity to CRISPR/Cas9 could enhance ls-KI efficiency. To tes…
  pubmed Zhao D, Zhao X, Gao Y, Yang S 等 2026 Jul 29 置信度 0.82
• An optimized CRISPR/Cas9-based genome editing platform enhances bacteriocin production in Lactiplantibacillus plantarum.
  Efficient genetic engineering of lactic acid bacteria remains technically challenging due to their thick peptidoglycan cell wall, low transformation efficiency, strain-specific restriction-modification systems, and sensitivity to Cas9-induced double-strand bre…
  pubmed Anand R, Lütticken R, De Laporte L, Herrmann A 等 2026 Jul 29 置信度 0.82
• In vivo CRISPR base editing for treatment of Huntington's disease.
  Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat within exon 1 of the huntingtin (HTT) gene, resulting in a mutant protein that drives neuronal dysfunction and loss. A key event in the pathogenesis of HD is prote…
  pubmed Shirguppe S, Gapinske M, Swami D, Shenouda K 等 2026 Jul 29 置信度 0.82
• In vivo delivery strategies for therapeutic CRISPR genome editing.
  CRISPR-based genome and epigenome editing technologies have rapidly evolved from programmable nucleases into a diverse therapeutic toolbox encompassing conventional CRISPR systems, base editing, prime editing, RNA targeting, and epigenetic modulation. While ea…
  pubmed Martin L, Bohinc J, Recchia A, Gritti S 等 2026 置信度 0.82
• Coumarin linker facilitates regulation of CRISPR/Cas9 activity using visible light.
  Photochemical control of CRISPR/Cas9 gene editing technology is an important tool for a variety biochemical applications. In the past, either photo-activation or photo-inactivation has been achieved using UV-light responsive chromophores, which are not ideal f…
  pubmed McClain I, Pandit B, Royzen M 2026 Jul 28 置信度 0.82
• CRISPR-based ex vivo gene editing of donor organs.
  Donor organs are frequently discarded because of concerns about quality or pathogen risk, challenges that could be mitigated through ex vivo gene editing or silencing during machine perfusion. Here, we discuss the development of CRISPR-based approaches for ex …
  pubmed Rananaware SR, Narisetty KV, Shah RA, Jain PK 2026 Jun 29 置信度 0.82
• Plant RNA interference from antiviral silencing to multiplex trait engineering for climate-resilient crops.
  RNA interference (RNAi) in plants has evolved from an unexplained antiviral and transgene interference phenomenon into a general regulatory platform for sequence-guided gene suppression, chromatin control, systemic signaling, and phenotypic plasticity. This Re…
  pubmed Abdurakhmonov IY 2026 置信度 0.82
• Recent advances of CRISPR-based gene editing technologies and delivery strategies.
  CRISPR technology is a powerful tool for gene editing, in which the efficient delivery of living target cells allows it to show great clinical potential. At present, the commonly used in vivo delivery strategies mainly include biological methods (AAV, VLP, SEN…
  pubmed Xue F, Xin Z, Wang G, Xing J 等 2026 Dec 置信度 0.82
• Advances in mutant characterization for detecting causal mutations in crop plants.
  Induced mutagenesis creates novel allelic variants to improve crop yield, climate resilience, and nutritional profile. However, utilizing these mutants effectively in breeding programs requires identification of the exact genetic lesions responsible for target…
  pubmed Bhad PG, Baradkar S, Mondal S, Badigannavar AM 2026 Jul 28 置信度 0.82
• Establishment of an efficient Agrobacterium-mediated transformation system and CRISPR/Cas9-mediated genome editing of the OvPDS1 gene in Oxalis vulcanicola 'Sunset Velvet'.
  This study overcomes a key technical barrier by establishing transformation and enabling first CRISPR/Cas9 editing in Oxalis, providing a platform for functional genomics and breeding. The lack of an efficient genetic transformation system has considerably hin…
  pubmed Tuo W, Wang X, Wu T, Zhang S 等 2026 Jul 28 置信度 0.82
• From one-size-fits-all to on-demand: personalized crispr gene editing for rare genetic liver diseases.
  Rare genetic liver diseases collectively affect millions of individuals worldwide and encompass a heterogeneous group of monogenic disorders including Wilson disease, alpha-1 antitrypsin deficiency, glycogen storage diseases, urea cycle disorders, progressive …
  pubmed Quan AT 2026 Jul 28 置信度 0.82
• Genome-wide identification, structural characterization, and evolutionary analysis of growth-related gene families in African catfish (Clarias gariepinus).
  The somatotropic axis encompassing growth hormone (GH), insulin-like growth factor (IGF), myostatin (MSTN), and prolactin (PRL) signalling cascades is the master regulator of somatic growth, metabolism, and development in vertebrates. African catfish (Clarias …
  pubmed Ja'afar Y, Ghara S, Ajith N, Rather MA 2026 Jul 22 置信度 0.82
• Long-read sequencing and next-generation CRISPR editors: a unified pipeline for rare disease precision medicine with ethical and regulatory perspectives.
  Rare diseases, most of which have a genetic basis, remain a major challenge due to diagnostic delays and limited therapeutic options, particularly within the Middle Eastern regions. These countries exhibit a heightened prevalence of genetic disorders attributa…
  pubmed Konamveettil Abdul Latheef A, Ali M, Farahat O, Gourari F 等 2026 置信度 0.82
• SLC3A2 promotes early-stage of Zika virus infection in human placental cells and astrocytes.
  Zika virus (ZIKV) has been associated with neonatal microcephaly or atypical Guillain-Barr&#xe9; syndrome in adults since 2016. However, despite considerable progress in understanding the biology and pathogenesis of ZIKV infection, little is known about its en…
  pubmed Chen Z, Feng D, Liu J, Chen J 等 2026 Jul 置信度 0.82
• Integrated analysis of organelle RNA editing and DYW- type PPR genes identifies a candidate regulator of plastid ndhD-878 editing under drought stress in soybean.
  RNA editing in plant organelles is an important post-transcriptional process that helps maintain organelle gene function and may contribute to plant responses to environmental stress. However, drought-responsive RNA editing events and their regulatory factors …
  pubmed Liu Y, Wang B, Qi Z, Chen Q 等 2026 置信度 0.82
• Production of gene-edited cloned cattle embryos using the CRISPR/EOCas12i system.
  The rapid development of genome editing technologies has enabled precise manipulation of livestock genomes for the improvement of production traits such as meat yield and milk quality. Myostatin ( MSTN ) and &#x3b2;-lactoglobulin ( BLG ) are key gene targets f…
  pubmed Wang F, Chen L, Ning Y, He J 等 2026 置信度 0.82
• Public knowledge, attitudes, and ethical views on CRISPR-Cas9 gene editing for genetic diseases in Taif, Saudi Arabia.
  Public support for gene editing, particularly for therapeutic purposes, remains strong. Recently, the Ministry of Health in Saudi Arabia approved CRISPR-Cas9 for treating Sickle Cell Disease and beta thalassemia. This study aims to assess the Taif population's…
  pubmed Alnefaie GO, Alsayed OH, Alsalmi YI, Algethami DS 等 2026 Jul 28 置信度 0.82
• Developing new tomato lines in Indigo Rose genetic background with differential anthocyanin and carotenoid production in fruits.
  Tomato ( Solanum lycopersicum ) fruit pigmentation during ripening results primarily from carotenoid accumulation and chlorophyll degradation, with flavonoids, particularly anthocyanins in specialized genotypes, contributing to fruit coloration. To develop tom…
  pubmed Tian D, Sng BJR, Phang IRK, Leong SH 等 2026 置信度 0.82
• A Practical Experimental Protocol for Identification and Validation of UFMylation Substrate in Human Cells.
  UFMylation is an evolutionarily conserved ubiquitin-like modification that covalently conjugates UFM1 to lysine residues of substrates via a sequential E1-E2-E3 enzymatic cascade. UFMylation plays a pivotal role in maintaining cellular homeostasis, and its dys…
  pubmed Liang Q, Fang Y, Dong J, Yi X 等 2026 Jul 20 置信度 0.82
• Gene Editing in Chlamydomonas Using the SCREAM Technique.
  In the model alga Chlamydomonas reinhardtii , CRISPR (clustered regularly interspaced short palindromic repeat)-based gene editing using Cas (CRISPR-associated) enzymes enables both (a) insertion of large gene cassettes and (b) the creation of knockouts based …
  pubmed Ross IL, Hankamer B 2026 Jul 20 置信度 0.82
• Making Donor Cells Invisible: A Leap Forward in the Fight Against Type 1 Diabetes.
  pubmed Kumar D, Choudhary N 2026 Jul 22 置信度 0.82
• KNOX1 Transcription Factors in Plants with a Special Focus on Horticultural Crops: A Review.
  Class I KNOX1 (KNOTTED1-like homeobox 1) transcription factors integrate gibberellin (GA), cytokinin (CK), and auxin (IAA) signaling to maintain shoot apical meristem identity and coordinate plant organogenesis. This review examines the structural conservation…
  pubmed Cai X, Chen K, Ye L, Bibi L 等 2026 Jul 9 置信度 0.82
• Global Research Trends on Polyhydroxyalkanoate-Producing Microorganisms: A Bibliometric and Scientometric Analysis of Sustainable Bioplastic Biotechnology.
  This scientometric and bibliometric study analyzes global research trends on polyhydroxyalkanoate (PHA)-producing microorganisms and their applications in bio-based packaging between 2014 and 2025. Using the Scopus database and advanced tools such as Bibliomet…
  pubmed De La Cruz-Noriega M, Sabogal Vargas AM, Rojas Villacorta W, Salvatierra Espinola W 等 2026 Jul 15 置信度 0.82
• Breast Cancer: Epidemiology, Molecular Classification, Diagnostics and Evolving Treatment Paradigms.
  Breast cancer remains one of the most prevalent malignancies affecting women worldwide and continues to be a leading cause of cancer-related morbidity and mortality. Patients may present with either localized or advanced disease, with clinical outcomes increas…
  pubmed Unuofin JO, Adefisan-Adeoye AO, Paimo OK, Maphetu N 等 2026 Jul 22 置信度 0.82
• Sickle Cell Disease: From Ancient Origins to Modern Breakthroughs in Gene Therapy.
  Sickle Cell Disease (SCD) is a hereditary hemoglobinopathy arising from a single-nucleotide transversion (GAG &#x2192; GTG) at codon six of the HBB gene on chromosome 11, substituting glutamic acid with valine in the &#x3b2;-globin chain and producing hemoglob…
  pubmed Ikolo B, Oyelami M, Mgbeke O, Jones K 等 2026 Jul 22 置信度 0.82