-
crossref
2024-12-12T00:10:02Z
置信度 0.70
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crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
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ABSTRACT Bioprocessing harnesses the potential of microbial communities and monocultures to convert renewable resources like agricultural by-products and wastewater into valuable products. While monocultures offer simplicity and control, microbial communities …
crossref
Lavanya Raajaraam, Karthik Raman
2024-11-04T01:20:17Z
置信度 0.70
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Abstract Background Gastric cancer (GC) is a frequent malignancy of the gastrointestinal tract. Exploring the potential anoikis mechanisms and pathways might facilitate GC research. Purpose The authors aim to determine the significance of anoikis‐related genes…
crossref
Yongjian Lin, Jinlu Liu
2024-02-20T17:48:18Z
置信度 0.70
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crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
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crossref
F.R. Schubert, S. Dietrich
2024-03-08T21:04:19Z
置信度 0.70
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Abstract During embryogenesis, homogenous groups of cells self-organize into stereotypic spatial and temporal patterns that make up tissues and organs. These emergent patterns are controlled by transcription factors and secreted signals that regulate cellular …
crossref
Miri Adler, Ruslan Medzhitov
2024-11-20T12:35:17Z
置信度 0.70
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crossref
Marco Ledda, Marta Bertolaso
2024-10-31T23:36:25Z
置信度 0.70
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crossref
2024-09-10T11:10:46Z
置信度 0.70
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Abstract In many fields, research progress may be hindered by indefiniteness of language used to describe experimental conditions and outcomes. Harmonization of data resources generated by independent groups is important for integrative analysis. Adoption of f…
crossref
Robert Gentleman, Rafael Goncalves, Vincent Carey
2024-06-28T18:35:18Z
置信度 0.70
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crossref
2024-03-05T16:08:56Z
置信度 0.70
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crossref
Kohki Okabe, Shingo Sotoma, Yoshie Harada
2024-09-18T14:21:04Z
置信度 0.70
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crossref
Aurora Piombarolo, Cristiano Ialongo, Mariano Bizzarri, Antonio Angeloni
2023-12-07T12:03:02Z
置信度 0.70
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Abstract Increasing evidence suggests the tumor microenvironment (TME) governs solid tumor response to immune checkpoint inhibition (ICI). Decoding the relationship between the cell compositional diversity of the tumor microenvironment (TME) and the therapeuti…
crossref
Priyan Bhattacharya, Rajanikanth Vadigepalli
2024-09-27T20:00:15Z
置信度 0.70
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Abstract Biological systems exhibit complex dynamics that differential equations can often adeptly represent. Ordinary differential equation models are widespread; until recently their construction has required extensive prior knowledge of the system. Machine …
crossref
Xiaojun Wu, MeiLu McDermott, Adam L. MacLean
2024-10-04T20:25:36Z
置信度 0.70
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Abstract Biochemical reaction systems in a cell exhibit a stochastic behaviour, owing to the unpredictable nature of the molecular interactions. The fluctuations at the molecular level may lead to a different behaviour than that predicted by the deterministic …
crossref
Fauzia Jabeen, Silvana Ilie
2024-11-07T01:10:39Z
置信度 0.70
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crossref
Jonas O. Wolff, Daniela C. Rößler
2024-07-22T10:35:52Z
置信度 0.70
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crossref
Jiayao Zhou, Shudan Yan
2025-01-17T05:04:31Z
置信度 0.70
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crossref
Yin Hoon Chew, Lucia Marucci
2024-03-05T16:08:56Z
置信度 0.70
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crossref
Ning Wang, Guocheng Zhang, Manman Li
2025-07-12T01:37:03Z
置信度 0.70
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crossref
Monty Montano, Venkataramana Sidhaye, Martin Trapecar, Deok‐Ho Kim
2024-07-08T22:27:43Z
置信度 0.70
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crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
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crossref
Carter Norton, Chad Pollard, Kelaney Stalker, Kenneth Aston 等
2024-06-23T01:11:07Z
置信度 0.70
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Abstract RNA viruses are known for their fascinating evolutionary dynamics, characterised by high mutation rates, fast replication, and ability to form quasispecies - clouds of genetically related mutants. Fast replication in RNA viruses is achieved by a very …
crossref
K.B. Blyuss, Y.N. Kyrychko
2024-01-29T23:00:14Z
置信度 0.70
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Abstract In most situations, eukaryotic cells proceed irreversibly through the cell division cycle (G1-S-G2-M) in order to produce two daughter cells with the same number and identity of chromosomes of their progenitor. The integrity of this process is maintai…
crossref
Béla Novák, John J. Tyson
2024-01-24T17:45:17Z
置信度 0.70
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crossref
Xinpeng Lan, Wu Liji Ao, Ji Li
2024-02-07T12:52:16Z
置信度 0.70
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crossref
Maximilian Flaiz, Diana Z. Sousa
2023-12-12T06:39:59Z
置信度 0.70
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Abstract This article used network pharmacology, molecular docking, GEO analysis, and Gene Set Enrichment Analysis to obtain 38 main chemical components and 66 corresponding targets involved in Alzheimer's disease (AD) treatment in "Cistanche deserticola‐Polyg…
crossref
Shaoqiang Wang, Yifan Wang
2024-10-11T15:39:16Z
置信度 0.70
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Abstract Gene expression responds to various perturbations, such as mutations, environmental changes, and stochastic perturbations. The variability in gene expression levels differs among genes, influencing the availability of adaptive variants or mutants and …
crossref
Saburo Tsuru, Chikara Furusawa
2024-08-19T14:35:25Z
置信度 0.70
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Imaginary coquaternions cℍ can be represented by matrices of negative feedback N^-, positive feedback P^+ and reciprocal links R^± . Added environmental element E^± endows biologic systems with the structure of cℍ module. Although cℍ representation links base …
crossref
Garri Davydyan
2024-12-19T03:04:52Z
置信度 0.70
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crossref
Leah Cooper, Emma Manuel, Min Xu, Samantha B. Schon
2024-12-26T02:31:26Z
置信度 0.70
-
crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
-
crossref
Vaishnavee Thote, Susha Dinesh, Sameer Sharma
2024-04-17T16:34:30Z
置信度 0.70
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Abstract Intracranial haemorrhage (ICH) is an urgent and potentially fatal medical condition caused by brain blood vessel rupture, leading to blood accumulation in the brain tissue. Due to the pressure and damage it causes to brain tissue, ICH results in sever…
crossref
Haiyan Liu, Yu Zeng, Hao Li, Fuxin Wang 等
2024-11-24T23:39:27Z
置信度 0.70
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Abstract Cancer treatment often involves heat therapy, commonly administered alongside chemotherapy and radiation therapy. The authors address the challenges posed by heat treatment methods and introduce effective control techniques. These approaches enable th…
crossref
Seyed Ehsan Razavi, Hamed Khodadadi, Masoud Goharimanesh
2024-05-24T22:45:32Z
置信度 0.70
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Revealing interactions in complex systems from observed collective dynamics constitutes a fundamental inverse problem in science. Some methods may reveal undirected network topology, e.g., using node-node correlation. Yet, the direction of the interaction, thu…
crossref
Nava Leibovich
2024-04-20T23:23:55Z
置信度 0.70
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crossref
2024-12-12T00:10:02Z
置信度 0.70
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crossref
Bartholomew W. Green
2024-10-07T14:58:39Z
置信度 0.70
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Abstract Vaccination has proven to be the most effective public health measure in the fight against various infectious diseases. For emerging or re-emerging diseases, a highly efficacious vaccine may not be available at the start of an outbreak. Timelines for …
crossref
Gergely Röst, Zhen Wang, Seyed M. Moghadas
2024-02-11T01:45:12Z
置信度 0.70
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Maintaining good water quality is essential for successful fish production in land-based recirculating aquaculture systems (RAS). Numerous interdependent factors influence water quality parameters, making it difficult to evaluate which operational strategies a…
crossref
Marie Aline Montjourides, Susanna Roblitz, Hakon Dahle
2024-07-02T14:16:57Z
置信度 0.70
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crossref
Juliana Rangel
2024-05-20T14:37:34Z
置信度 0.70
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crossref
Krishnendu Ghosh, Caroline Goodman
2024-02-25T23:28:51Z
置信度 0.70
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crossref
Makoto Tominaga, Makiko Kashio
2024-09-18T10:21:04Z
置信度 0.70
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crossref
Jian Xu
2024-02-07T09:02:53Z
置信度 0.70
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Abstract Motivation Molecular interaction networks are powerful tools for studying cellular functions. Integrating diverse types of networks enhances performance in downstream tasks such as gene module detection and protein function prediction. The challenge l…
crossref
Nure Tasnina, T. M. Murali
2024-02-06T05:10:30Z
置信度 0.70
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crossref
Vural Özdemir
2024-09-03T16:54:31Z
置信度 0.70
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crossref
Niloufar Abhari, Caroline Colijn, Arne Mooers, Paul Tupper
2023-12-05T23:01:10Z
置信度 0.70
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Abstract Computational modelling of cell state transitions has been a great interest of many in the field of developmental biology, cancer biology and cell fate engineering because it enables performing perturbation experiments in silico more rapidly and cheap…
crossref
Da Peng, Patrick Cahan
2024-06-03T12:10:53Z
置信度 0.70
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crossref
Sajad Majeed Zargar, Asmat Farooq, Parvaze Ahmad Sofi, Jebi Sudan 等
2024-08-16T04:57:44Z
置信度 0.70
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Abstract: Mathematical modeling of complex systems provides a rigorous framework for representing, analyzing, and predicting the behaviors that emerge from interacting components across diverse domains. This book develops an integrated conceptual and methodolo…
crossref
Murali Krishna Pasupuleti
2025-08-16T02:53:25Z
置信度 0.70
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Abstract Microbes tune their metabolism to environmental challenges by changing protein expression levels, metabolite concentrations, and reaction rates simultaneously. Here, we establish an analytical model for microbial resource allocation that integrates en…
crossref
Leon Seeger, Fernanda Pinheiro, Michael Lässig
2024-03-28T03:50:15Z
置信度 0.70
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crossref
Samman Munir, Usman Ali Ashfaq, Muhammad Qasim, Tazeem Fatima 等
2024-02-23T09:05:29Z
置信度 0.70
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crossref
Didier Gonze
2024-02-01T20:53:04Z
置信度 0.70
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crossref
Amir Bitran, William M. Jacobs, Eugene Shakhnovich
2023-11-22T22:02:39Z
置信度 0.70
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Abstract Genetic manipulation of cells to couple byproduct production and growth rate is important in bioengineering and biotechnology. In this way, we can use growth rate as a selective pressure, where the mutants with higher growth have higher production cap…
crossref
Omid Oftadeh, Vassily Hatzimanikatis
2024-02-02T20:45:23Z
置信度 0.70
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crossref
James Morrissey, Benjamin Strain, Cleo Kontoravdi
2024-03-05T16:08:56Z
置信度 0.70
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Abstract Phylogenetic tree reconstruction relies on accurate estimation of evolutionary distances between sequences. However, the observed Hamming distance between sequences can be misleading due to saturation, where multiple substitutions at the same site obs…
crossref
Emunefe Friday Gabriel, Ugbene Ifeanyichukwu Jeff
2024-07-30T20:50:11Z
置信度 0.70
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Invading new territory is a central aspect of the microbial lifestyle, allowing microbes to expand to remote locations and pathogens to spread and infect their hosts. However, invading microbes rarely find novel territories uninhabited. In such a scenario, res…
crossref
Xiaozhou Ye, Or Shalev, Christoph Ratzke
2024-10-16T12:50:15Z
置信度 0.70
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crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
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crossref
Eric H. Chang
2024-11-06T04:54:11Z
置信度 0.70
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crossref
Pamela Stokes
2024-10-18T18:57:24Z
置信度 0.70
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Abstract Sepsis is a severe systemic inflammatory syndrome triggered by infection and is a leading cause of morbidity and mortality in intensive care units (ICUs). Immune dysfunction is a hallmark of sepsis. In this study, the authors investigated cell‐cell co…
crossref
Yanyan Tao, Miaomiao Li, Cheng Liu
2024-11-23T02:04:07Z
置信度 0.70
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crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
-
crossref
Mark Hollins
2024-08-28T19:10:46Z
置信度 0.70
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crossref
Matthew C. Ward
2024-11-14T21:12:02Z
置信度 0.70
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crossref
Alison M. Bell
2024-11-15T18:22:58Z
置信度 0.70
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crossref
Mohd. Tashfeen Ashraf, Abdul Arif Khan, Fahad M. Aldakheel
2024-02-23T09:05:01Z
置信度 0.70
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crossref
Ernst Weber
2024-03-05T16:08:56Z
置信度 0.70
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crossref
Sohini Chakraborty, Satarupa Banerjee
2024-05-16T19:01:51Z
置信度 0.70
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crossref
2023-11-06T14:02:39Z
置信度 0.70
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Abstract Interconnected feedback loops are prevalent across biological mechanisms including cell fate transitions enabled by epigenetic mechanisms driving phenotypic plasticity of carcinoma cells. However, the operating principles of these networks remain larg…
crossref
Abhiram Hegade, Mubasher Rashid
2024-05-30T15:30:11Z
置信度 0.70
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crossref
Hengrui Zhou, Hyunmin Eun, Sang Yup Lee
2023-11-25T07:30:46Z
置信度 0.70
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Abstract Excretory systems have two separate roles: elimination of waste products and maintaining a correct ion balance. Waste products are mostly breakdown products of nitrogenous compounds, which include toxic ammonia. The excretory system has to detoxify an…
crossref
Ariel D. Chipman
2024-04-30T03:06:30Z
置信度 0.70
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crossref
Helmut Sigel
2024-10-18T14:06:39Z
置信度 0.70
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Abstract Cellular metabolism is a highly interconnected network with thousands of reactions that convert nutrients into the molecular building blocks of life. Metabolic connectivity varies greatly with cellular context and environmental conditions, and it rema…
crossref
Samuel Cain, Charlotte Merzbacher, Diego A. Oyarzún
2024-06-03T11:45:57Z
置信度 0.70
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We introduce a mathematical model of the cancer-immunity cycle and use it to test several hypotheses regarding the combination, timing, and optimization associated with chemotherapy and immunotherapy dosing schedules in the context of competition and selection…
crossref
S. Mahmoodifar, P.K. Newton
2024-11-04T01:00:18Z
置信度 0.70
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Summary Understanding of overall metabolisms of guard cell (GC) and mesophyll cell (MC), their possible interactions and roles in stomatal movement will help in designing crop plants with higher water use efficiencies. Although, previous constraint based model…
crossref
Devlina Sarkar, Sudip Kundu
2024-06-03T11:37:32Z
置信度 0.70
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Abstract To self-renew, stem cells must precisely balance proliferation and differentiation. Typically, this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic self-renewal program that allows them to do so autonomously, a…
crossref
Ben D MacArthur, Philip Greulich
2024-12-20T18:05:15Z
置信度 0.70
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crossref
Loan Thi Ngoc DINH, Priyabrata Karmakar
2024-01-01T21:49:38Z
置信度 0.70
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Abstract Background T he solution space of an FBA-based model of cellular metabolism, can be characterised by extraction of a bounded, low dimensional kernel (the SSK) that facilitates perceiving it as a geometric object in multidimensional flux space. The aim…
crossref
Wynand S. Verwoerd, Longfei Mao
2024-06-12T13:50:28Z
置信度 0.70
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Sustainability of livestock systems encompasses social, economic, and environmental concerns. Environmental sustainability issues surrounding livestock production include greenhouse gas emissions, land use, water use, and water quality. Mitigating negative env…
crossref
Sara E. Place
2024-06-26T11:55:09Z
置信度 0.70
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Abstract The transforming growth factor‐β (TGF‐β) superfamily, including Nodal and Activin, plays a critical role in various cellular processes. Understanding the intricate regulation and gene expression dynamics of TGF‐β signalling is of interest due to its d…
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Dan Shi, Weihua Feng, Zhike Zi
2024-01-09T09:59:36Z
置信度 0.70
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Abstract EMT dysfunction is a dominant mechanisms of hypospadias. Thus, identification of EMT‐related lncRNAs based on transcriptome sequencing data of hypospadias might provide novel molecular markers and therapeutic targets for hypospadias. First, the microa…
crossref
Hongjie Gao, Chen Ding, Mengmeng Chang, Zhiyi Lu 等
2024-07-25T06:43:27Z
置信度 0.70
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Abstract The world is teeming with information that can be collected by an organism and used to improve its chance of survival. Different sources of information are known as sensory modalities. Sense organs in diverse animals are optimized for detecting and in…
crossref
Ariel D. Chipman
2024-04-30T03:06:30Z
置信度 0.70
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Abstract Oscillators are fundamental to biological systems, underpinning essential processes such as cell division, circadian rhythms, and developmental cycles. While both natural and synthetic genetic oscillators have been extensively studied, oscillatory beh…
crossref
Vincent Vandenbroucke, Lucas Henrion, Frank Delvigne
2024-09-23T11:30:22Z
置信度 0.70
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Abstract This study explores the intricate world of protein-protein interaction (PPI) networks and the critical role of hub proteins within them. PPIs, mediated by various biomolecular forces, orchestrate diverse cellular processes through transient or stable …
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Anju K. Ojha, Pawan K. Dhar
2024-03-23T20:45:11Z
置信度 0.70
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80