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There is an evident need for novel ophthalmic therapeutics that operate outside the conventional antibiotic and chemically synthetized antiseptic paradigms. Medicinal plants represent a chemically rich and cost-effective source of bioactive compounds, though t…
pubmed
Dzięgielewska M, Zielińska S, Khan T, Qudus MS 等
2026
置信度 0.82
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This study aimed to compare changes in 9-11 years old Italian children for fitness outcomes, following a structured multicomponent intervention, The Daily Mile, and usual school physical education lessons (i.e., control group). Before and after three di…
pubmed
Lupo C, Boccia G, Li Volsi D, De Pasquale P 等
2026
置信度 0.82
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Extrusion conditions and particle size significantly influenced the formation of Maillard reaction products (MRP) in rice flour and bread crust-like model system. In extruded rice flour (<132 μm and > 132-200 μm; barrel te…
pubmed
Różańska MB, Mogol BA, Gökmen V
2026 Aug
置信度 0.82
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Teratology, the study of congenital anomalies, has developed from a descriptive discipline into a mechanistic science focused on the proximate causes of developmental defects, meaning how such anomalies arise during development. However, a comprehensive unders…
pubmed
Kon T
2026 Jan-Feb
置信度 0.82
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Salt-dependent traditional fermented foods rely on the selective ecological environment created by salt to develop characteristic flavor, maintain fermentation stability, and ensure product safety. However, the health risks associated with excessive sodium int…
pubmed
Shen S, Shao Z, Atta-Delgado MX, Chen X 等
2026 Sep
置信度 0.82
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Premenstrual syndrome (PMS) affects many women of reproductive age, often disrupting daily activities. Mindfulness- and relaxation-based techniques, such as yoga and progressive muscle relaxation techniques, can alleviate both physical and psychosocial symptom…
pubmed
Obembe A, Ramos J, Reis E, Souerdyke G 等
2026 Aug 25
置信度 0.82
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Peri-implantitis is a biofilm-associated inflammatory condition characterized by peri-implant mucosal inflammation and progressive bone loss. The prevalence of peri-implantitis continues to rise among patients with dental implants. Although peri-implantitis an…
pubmed
Yan Y, Suvan J, D'Aiuto F
2026 Aug 25
置信度 0.82
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Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction-associated steatotic liver diseas…
pubmed
de Molon RS, de Avila ED, da Silva Barbirato D, Fogacci MF 等
2026 Aug 25
置信度 0.82
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This review summarizes the RECOVER trial's key findings and their clinical and research implications. RECOVER was a 12-month triple-blind randomized trial in adults with markedly treatment-resistant major depressive disorder (N=493; at least four failed trials…
pubmed
Conway CR, Sackeim HA, Rush AJ, Bunker M 等
2026 Aug 26
置信度 0.82
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Type 2 diabetes (T2D) and obesity are established risk factors for Alzheimer's disease and related dementias, yet the cerebrovascular mechanisms linking metabolic dysfunction to cognitive decline remain poorly understood. This study aims to assess BBB water pe…
pubmed
Saha A, Shi W, Elsharydah MN, Schaffert J 等
2026 Jul 22
置信度 0.82
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Comprehensive palliative care is essential for improving the quality of life of women with breast and cervical cancer in Ethiopia, yet services remain poorly organized, largely inaccessible, and concentrated in the capital. While existing studies have quantifi…
pubmed
Deribe KS, Shewaye S, Habtamu NS, Wondimagegnehu A 等
2026 Aug 25
置信度 0.82
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Breast cancer is one of the most prevalent malignancies among women, and despite improved survival associated with endocrine therapy, treatment-related adverse effects significantly affect quality of life, particularly sexual health. This study aimed to descri…
pubmed
Oliveira CE, de Oliveira PBR, Santos CR, Alves IA
2026 Aug 26
置信度 0.82
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Non-muscle-invasive bladder cancer (NMIBC) is a chronic and recurrent condition requiring repeated intravesical treatments and lifelong surveillance, imposing a substantial burden on patients. Patient-reported outcomes (PROs) are increasingly required by regul…
pubmed
Griebsch I, Shrestha S, Gotay CC, Gore JL 等
2026 Aug 25
置信度 0.82
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Boron-containing compounds have become an important class of scaffolds in medicinal chemistry, broadening the chemical space available for drug discovery. This review summarizes progress and key advances reported over the past 5 years in the development of bio…
pubmed
Behringer M, Kühn JR, Meyer-Almes FJ
2026 Aug 27
置信度 0.82
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The insidious nature of aortic stenosis (AS) combined with the advanced age of the affected population results in underreporting of symptoms and underestimation of impact on functional capacity and quality of life. Although guidelines recommend early valve rep…
pubmed
Khan N, Steeds RP, Mehta S, Sun Y 等
2026 Aug 25
置信度 0.82
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Type III secretion system effectors (T3SEs) are small bacterial proteins with big biological roles. They act as central molecular mediators of interactions between Gram-negative bacteria and eukaryotic hosts, spanning pathogenic, symbiotic and environmental co…
pubmed
Rosić I, Nikolić I
2026 Aug 26
置信度 0.82
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Electronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use for this purpose.…
pubmed
Lindson N, Livingstone-Banks J, Butler AR, McRobbie H 等
2026 Aug 26
置信度 0.82
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Methylation profile scores (MPSs) aggregate the effects of many DNA methylation (DNAm) sites across the genome into a single continuous value per individual. These scores are rapidly gaining traction in health research, as they translate DNAm patterns into sum…
pubmed
Schuurmans IK, Defina S, Hermans APC, Neumann A 等
2026 Aug 25
置信度 0.82
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Resilience, defined as the capacity to recover from difficulties or to adapt well to stressors, challenges, and adversities in life, is increasingly studied, yet its role in a range of alcohol-related outcomes remains unclear, including alcohol consumption, ri…
pubmed
Alen GD, Kuntsche E, Ingram I, Otten R 等
2026 Aug 22
置信度 0.82
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Health-related quality of life (HRQoL) is central to treatment decisions. We conducted a meta-analysis to assess treatment effects on patient-reported HRQoL in non-small cell lung cancer (NSCLC).
pubmed
Giddings R, Naidu SB, Langan D, Thorpe A 等
2026 Aug 25
置信度 0.82
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Assessing social frailty in cancer care is crucial because a patient's support, resources, and social stability can determine whether they can receive, tolerate, and complete treatment, ultimately influencing their outcomes and quality of life. This review aim…
pubmed
Ho MH, Montayre J, Wang L, Xin G 等
2026 Aug 20
置信度 0.82
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The global nursing shortage poses critical challenges for healthcare systems. Understanding nursing student dropout, particularly which factors contribute to this process and when they emerge during the curriculum, is crucial for developing timely and effectiv…
pubmed
Viottini E, Conti A, Bova C, Martin B 等
2026 Aug 10
置信度 0.82
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Cancer immunotherapy has reshaped oncology, yet its broad application is constrained by an immunosuppressive tumor microenvironment and the systemic toxicities of conventional treatments. This review traces the evolution of nanomedicine from a passive drug del…
pubmed
Wu Y, Tang F, Lee J, Liang Y 等
2026 Aug 17
置信度 0.82
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Alternative community-based housing models (CBHMs) for aging in place (AIP) have emerged in recent years as options to residential or nursing home care. These models aim to support older adults while enhancing quality of life (QoL).
pubmed
Ruiz-Grao MC, Rodríguez-Martín B, Rodríguez-Cedrés A, de Miguel-Brox M 等
2026 Aug 25
置信度 0.82
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Graft failure following anterior cruciate ligament reconstruction (ACL-R) is a significant complication. A smaller Notch Width Index (NWI) has been proposed as a potential risk factor, although there is conflicting evidence regarding smaller notch morphology a…
pubmed
Nicholas PRM, Ulla S, Rankin CS, Young D 等
2026 Aug 25
置信度 0.82
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Engineered bacterial therapeutics integrate programmable strain engineering with biomedical functions such as sensing, delivery, immune modulation, microbiome intervention, and disease management. This study conducted a multi-database bibliometric analysis to …
pubmed
Zhou H, He J, Chen J, Ge S 等
2026 Dec
置信度 0.82
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Ferroptosis is a distinct modality of programmed cell death driven by iron-dependent lipid peroxidation, exerting a pivotal regulatory influence on the infection dynamics and immune responses associated with zoonoses. This article systematically elucidates the…
pubmed
Tian L, Cheng X, Ni J, Yang R 等
2026 Dec
置信度 0.82
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Ovarian tissue cryopreservation (OTC) has emerged as an important fertility-preservation strategy for patients undergoing gonadotoxic treatment. However, this approach remains vulnerable to freeze-thaw-associated cellular injury driven by oxidative stress, mit…
pubmed
Zand E, Zhang B, Zhao G
2026 Aug 25
置信度 0.82
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Extracorporeal membrane oxygenation (ECMO) has a life-saving role in trauma management, with particular relevance to patients with acute respiratory failure. This narrative review describes the current evidence on the use of ECMO in the resuscitation of major …
pubmed
Akman C, Ucar AB, Yilmaz G, Erdem AB 等
2026 Aug 25
置信度 0.82
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The 16S rRNA gene has - and continues to - play an important role in microbiology. It's universality across prokaryotes and variation across species has allowed the sequencing of its hypervariable regions to be used to distinguish taxa within complex mixed bac…
pubmed
Whelan FJ, Hall LJ
2026 Aug
置信度 0.82
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Microbiome genomics has achieved remarkable resolution of community structure, yet composition alone remains an unstable basis for inferring host-relevant biology. That instability reflects a broader interpretive problem in which taxonomically distinct communi…
pubmed
Lewandowski R
2026 Aug
置信度 0.82
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In this Review, we summarize recent conceptual and technological advances in single-cell glycomics, with a particular focus on emerging strategies that enable glycan-resolved analysis of tumor-immune interactions. We highlight single-cell glycan and RNA sequen…
pubmed
Anh DXT, Tateno H
2026 Aug
置信度 0.82
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Aging is characterized by chronic inflammation involving a continuous, multifarious, low-grade inflammatory response that contributes to age-related chronic diseases. Recently, researchers have focused on age-related chronic inflammation and anti-inflammatory …
pubmed
Arulkumar R, Noh SG, Jung HJ, Kim S 等
2026 Aug 25
置信度 0.82
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Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra-rare condition, characterised by complement-mediated red blood cell breakdown, resulting in haemolytic anaemia. Associated symptoms, such as fatigue, impact on patient quality of life. Little is known abou…
pubmed
Han B, Balp MM, Snellman J, Wiyani A 等
2026 Aug 25
置信度 0.82
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High levels of blood cholesterol are a major risk factor for atherosclerotic cardiovascular disease and require early and consistent utilization of statins as first-line medications to avoid disabling or even deadly consequences. Nevertheless, real-world treat…
pubmed
Strollo F, Guarino G, Satta E, Caccavale G 等
2026 Aug 25
置信度 0.82
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Electrocardiogram (ECG) evaluation after return of spontaneous circulation (ROSC) represents a crucial step in the diagnostic work-up of sudden cardiac death (SCD) survivors. Among ECG patterns, the Brugada syndrome (BrS) type 1 morphology, characterized by co…
pubmed
Calvelli P, Racco V, Curcio A
2026 Aug 25
置信度 0.82
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Biological soil crusts (biocrusts) are photosynthetic soil-surface consortia that stabilize dryland soils, regulate hydrological fluxes, support nutrient cycling, and promote ecosystem recovery. However, inoculation often performs inconsistently because propag…
pubmed
Salem H, Li T, Yin B, Zhang Y
2026 Aug 25
置信度 0.82
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Real-world evidence (RWE) is increasingly used to inform regulatory and payer policy decisions and health technology assessment, yet appraising the methodological credibility of RWE studies remains time-intensive and requires specialized expertise. The apprais…
pubmed
Okeke CM, Nechi R, Khalid J, Karaye IM 等
2026 Sep
置信度 0.82
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Schools are essential settings for teaching Basic Life Support (BLS). However, assessment methods for students vary considerably.
pubmed
Mecías-Calvo M, Sobrido-Prieto M, Navarro-Patón R
2026 Sep
置信度 0.82
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Cancer and heart failure (HF) frequently coexist due to population ageing and improved survival for both conditions. HF is a well-recognised complication of oncologic therapies and a potential association between HF and subsequent cancer incidence has been rec…
pubmed
Sanasi L, Iaconelli A, Azzolina D, Dolce P 等
2026 Aug 25
置信度 0.82
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Nonviral gene therapy reached unprecedented clinical prominence, with the approval of lipid nanoparticles (LNPs). Yet, their success remains largely confined to a narrow range of applications and tissues, which reflects the inherent functional constraints base…
pubmed
Baldari C, Leone C, Leccese G, De Stradis C 等
2026 Aug 25
置信度 0.82
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Plant invasion poses a serious threat to biodiversity and ecosystem functions, while habitat heterogeneity significantly affects the invasion trend along latitudinal gradients. We reviewed the research progress on plant invasion and its biological interaction …
pubmed
Wu H, Yang QW, Feng CC, Zeng QC 等
2026 Aug
置信度 0.82
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Facial asymmetry is a common sequela of condylar osteoma and has a significant impact on patient's quality of life. In some cases, sole resection of the tumor and surrounding structures is insufficient to restore maxillofacial harmony, and incorporating additi…
pubmed
Alsuwied DM, Alhomied M, Alolayan AB
2026
置信度 0.82
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Plants belonging to the genus Taxus are abundant in pharmacologically active constituents, notably Taxol (paclitaxel), which has been extensively employed in the treatment of various cancers. This review aims to achieve a comprehensive and up-to-date overview …
pubmed
Jiang Y, Zhang L, Ma H, Fang Z 等
2026
置信度 0.82
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Congenital heart disease is one of the most common congenital anomalies in children and remains a major contributor to neonatal morbidity, infant mortality, repeated hospitalisation, and lifelong cardiovascular care needs. The clinical spectrum ranges from min…
pubmed
Nabi MSM, Barik RR, Sharma A, Garima 等
2026 Jul
置信度 0.82
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Baduanjin, a traditional mind-body exercise, may provide benefits for both physical and psychological health among older adults. The present study systematically evaluated its effects on sleep quality, depressive symptoms, quality of life, body composition, an…
pubmed
Zhao L, Chong MC, Lee WL, Song W 等
2026
置信度 0.82
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Glutamate (Glu), the primary excitatory neurotransmitter of the central and peripheral nervous systems, plays essential roles in cognition, synaptic plasticity, and immune modulation. Its dysregulation is increasingly recognized as a component of neuroinflamma…
pubmed
Stamoula E, Vavilis T, Boskou I, Vampertzi O 等
2026
置信度 0.82
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Fetal life represents a critical period in the development of the neonatal immune system. During this period of high epigenomic plasticity, environmental exposures, maternal health conditions and perinatal factors can have a lifelong impact on gene expression …
pubmed
Dodwell W, Cousins D, Boyle E, Pillay T
2026
置信度 0.82
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The primary aim of this study was to assess, in Still's disease, whether the employment of canakinumab at a strictly on-label dose may increase the likelihood of treatment discontinuation due to study-defined long-term remission (LTR), compared with patients r…
pubmed
Vitale A, Caggiano V, Sbalchiero J, Lopalco G 等
2026
置信度 0.82
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Climate change threatens biodiversity by challenging animals' ability to balance energy and water budgets, across timescales ranging from (i) acute-lethal (hours-to-days) to (ii) chronic-sublethal (days-to-weeks). However, predicting the effects of heat exposu…
pubmed
Mdluli VM, Noakes MJ, Conradie SR
2026
置信度 0.82
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The global food system is under growing strain to deliver sufficient high-quality protein for a rising population, while curbing environmental degradation, tackling climate change, and maintaining long-term food security. Conventional livestock production is a…
pubmed
Ali S, Ali B, Ahmad K, Zhang L 等
2026
置信度 0.82
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Nutrition occupies a central and dynamic role across the inflammatory bowel disease (IBD) care continuum, from disease risk reduction and prevention, through induction and maintenance of remission, to the mitigation of disease-related and unrelated complicatio…
pubmed
Gold S, Haskey N, Freid H, Eisele M 等
2026
置信度 0.82
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Rechargeable batteries (RBs) have become the dominant technology in the energy storage market due to their high energy density, long cycle life, and versatility in applications ranging from portable electronics to electric vehicles. However, the performance of…
pubmed
Lv Y, Islam MS, Tejani GG, Lin F 等
2026 Jul 29
置信度 0.82
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AI assisted computed higher tumor infiltrating lymphocyte% (TIL%) scores from hematoxylin and eosin (H&E) stained whole slide images (WSI) may serve as a useful biomarker for stratifying patients for treatment with immune checkpoint inhibitors.
pubmed
Zhang Y, Cheng X, Liao Y, Adams S 等
2026
置信度 0.82
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This scoping review aims to develop a competency framework, based on the four wellbeing economy capitals, to support education, training and up-skilling of public health professionals and practitioners.
pubmed
Rodríguez-Feria P, Czabanowska K, Dyakova M, Giraldo-Noack N 等
2026
置信度 0.82
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Decidual macrophages (DMs) are strategically located at the maternal-fetal interface to orchestrate innate host defense while balancing tolerance to the allogenic fetus. An important pregnancy complication is chorioamnionitis characterized by infection/inflamm…
pubmed
Pithia N, Musumarra CV, Protti G, Del Vecchio G 等
2026
置信度 0.82
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pubmed
Song C, Cao Y, Sabir IA, Zhao W
2026
置信度 0.82
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Across all domains of life, functional amyloid fibrils serve structural, storage and signalling functions. In signalling pathways, assembly into the amyloid state constitutes a rapid and cooperative molecular switch that can reorganise protein function, promot…
pubmed
Buchanan JA, Williams BC, Steain M, Sunde M
2026 Aug 26
置信度 0.82
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Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into approved medicines remains slow, expensive, and prone to high attrition across the pipeline from target identification to clinical validation. Artificial in…
pubmed
U K, Zhang SM, Yu Z, Zhang Z 等
2026 Aug 25
置信度 0.82
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Conceptual framework linking anthropogenic chemical complexity to the restructuring of microbial resilience in the Anthropocene. Persistent, low-dose chemical mixtures can reorganize microbial coordination networks, regulatory and metabolic processes, and ecol…
pubmed
Fatta-Kassinos D, Naziri A, Manaia C, Coelho LP
2026 Aug
置信度 0.82
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Proteomics by mass spectrometry has rapidly matured from a niche method into a standard tool. The recent 10-year trajectory of single-cell proteomics has opened a new biological dimension for studying disease. Mitochondrial diseases, with their pronounced cell…
pubmed
Wetzel S, Mann SP, Rosenberger FA
2026 Sep
置信度 0.82
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Jasmonic acid (JA), one of the most pivotal plant hormones, has emerged as a central focus in plant biology research due to its extensive and diverse biological functions. This review synthesizes the significant advancements made over the past decade in unders…
pubmed
Wang R, Manda T, Movahedi A, Yang L
2026 Sep 24
置信度 0.82
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Synthetic biotechnology is a key driver of green biomanufacturing and a strategic pillar for China in leading the new scientific revolution and gaining a competitive edge in cutting-edge technologies. The training of talents in synthetic biology aligns with hi…
pubmed
Sun C, Zhang L, Chen X, Liu L 等
2026 Aug 25
置信度 0.82
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Anaerobic digestion is a process in which organic matter is converted into methane and carbon dioxide through the catalysis of bacteria and archaea under anaerobic conditions. It is of great significance for the natural material cycle and sustainable developme…
pubmed
Wang S, Luo X, Chen C, Lin A
2026 Aug 25
置信度 0.82
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Lasso peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) with mechanically constrained structures that provide high stability and target selectivity. Among them, lariocidin (LAR), produced by Paenibacillus sp. M2, represent…
pubmed
Mahdy A, Alam-ElDein KM, Amin I, Mohamed HH 等
2026 Aug 24
置信度 0.82
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High-level exposure to indoor air pollutants (IAPs), including volatile organic compounds (VOCs), has substantially contributed to the burden of disease in China over the past two decades. However, the contributions of different indoor VOC sources to the assoc…
pubmed
Liu N, Huang CS, Yin Y, Dai X 等
2026 Aug 24
置信度 0.82
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The Middle East is a significant hotspot for human hydatidosis caused by Echinococcus granulosus, a complex multi-stage pathogen exhibiting antigenic variation with diverse epitopes. Multi-epitope vaccines, designed using immunoinformatics, represent a promisi…
pubmed
Skhal D, Al Nahhas S, Skhal O, Abbady AQ
2026 Aug 11
置信度 0.82
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This systematic review was performed to evaluate the development and measurement properties of patient-reported outcome measures (PROMs) used in patients undergoing third molar surgery, in accordance with the Consensus-based Standards for the Selection of Heal…
pubmed
Maferano EFE, Martins-Filho PR, Perazzo MF, Silva PGB 等
2026 Aug 24
置信度 0.82
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Paramedics on an ambulance encounter acutely unwell children and are in a position to reduce demand on emergency departments through appropriate triage and non-conveyance decisions. How these decisions are made and what factors influence them are not completel…
pubmed
Robinson ST, Broughton W, Williams J
2026 Aug 24
置信度 0.82
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Patients undergoing open repair of abdominal aortic aneurysm face a lifesaving but profoundly demanding procedure that disrupts everyday life and creates challenges for their physical, emotional, and existential well-being. This review synthesizes qualitative …
pubmed
Heesemann S, Stie M, Noe BB, Jørgensen TM 等
2026 Sep
置信度 0.82
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The quality, flavor, and stability of fermented foods depend on the microbial community. However, microbial dynamics are difficult to observe directly, leading to limited control over fermentation. High-throughput sequencing is a revolutionary tool for microbi…
pubmed
Zhou H, Yan L, Zhang L, Wang R 等
2026 Oct 31
置信度 0.82
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Cell culture is a fundamental technique in food biomanufacturing. However, the inherent limitations of traditional serum-containing culture systems hinder the scalable application of cell culture in the food industry, thus driving the development of serum-free…
pubmed
Niu Q, Chen N, Ye Q, Wu Q 等
2026 Oct 31
置信度 0.82
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The viable but nonculturable (VBNC) state is a critical survival strategy utilized by bacteria in response to environmental stress. In this state, bacteria cannot be cultivated on media, while maintaining cellular integrity and metabolic activity and being cap…
pubmed
Wang J, Li Z, Liu X, Liang J 等
2026 Oct 31
置信度 0.82
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The minimal processing (MP) of pineapple stands out as an alternative for meeting the demand for fresh, safe, and ready-to-eat foods. However, peeling and cutting operations cause damage to the fruit's vegetable tissues, accelerate respiration, intensify enzym…
pubmed
Brito VG, Ampese LC, Marangoni Júnior L
2026 Oct 31
置信度 0.82
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As a protein-rich by-product of peanut oil extraction, peanut meal is widely used in animal feed. It is also becoming more widely acknowledged as a viable source of protein for food products. However, it is highly vulnerable to contamination by aflatoxins (AFT…
pubmed
Ma F, He Y, Yang R, Zhang L 等
2026 Oct 31
置信度 0.82
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Food colorants constitute a critical segment of the global food industry, with an anticipated market valuation of USD 36.58 billion by 2030. Mounting safety apprehensions regarding synthetic dyes, illustrated by the recent ban on FD&C Red No. 3, have inten…
pubmed
Li Z, Zhang J, Xiao J, Zhu Y 等
2026 Oct 31
置信度 0.82
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Probiotics play important roles in maintaining gut homeostasis and promoting host health. However, their oral delivery remains challenging because of substantial viability loss during gastrointestinal transit. pH-responsive delivery systems have emerged as a p…
pubmed
Feng Y, Chen R, Zhang L, Li D 等
2026 Oct 31
置信度 0.82
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Oxidative stress can trigger apoptosis, tissue damage, and the onset of various chronic diseases. By maintaining cellular homeostasis, antioxidants can effectively reduce the risk of diseases associated with oxidative damage, including cardiovascular diseases,…
pubmed
Bai X, Pan W, Xu M, Rafiq M 等
2026 Oct 31
置信度 0.82
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Bacillus cereus occupies an unusual position in food systems because individual strains may cause emetic intoxication, diarrhoeal toxicoinfection and spoilage, whereas selected strains have been investigated for agricultural, feed and food-biotechnology functi…
pubmed
Lei Y, Tang Y, Wei E, Liao Y 等
2026 Oct 31
置信度 0.82
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Ethylene is a key plant phytohormone that governs fruit ripening and senescence, and its effective removal is essential to reducing postharvest losses across global fruit and vegetable supply chains. Although several ethylene-regulating packaging systems have …
pubmed
Sultana A, Manzoor M, Whiteside S
2026 Oct 31
置信度 0.82
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The escalating global burden of chronic obstructive pulmonary disease (COPD) has outpaced the capacity of conventional management paradigms to deliver truly individualized care. This review offers a critical, narrative synthesis of the role of artificial intel…
pubmed
Otaru AJ, Abubakar FZ, Ibitoye MO
2026 Aug 27
置信度 0.82
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Ivonescimab has shown clinical efficacy in non-small-cell lung cancer (NSCLC). We aimed to assess the efficacy and safety of ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated NSCLC whose disease progressed af…
pubmed
Le X, Passaro A, Zhao Y, Huang Y 等
2026 Sep
置信度 0.82
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Microbial food, food and ingredients produced leveraging microorganisms, represents a promising pathway toward sustainable and nutritious food systems. Translation of microbial food to everyday life, however, has lagged behind because of economic feasibility, …
pubmed
Asih SC, Choi KR
2026 Aug 24
置信度 0.82
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This comprehensive review explores nursing interventions and innovations in chemotherapy management, focusing on enhancing patient well-being through holistic and personalized care approaches. Nursing interventions play a critical role in managing physical sym…
pubmed
Ghasemi H, Talebi E, Khavari M, Amarlo F 等
2026 Aug 24
置信度 0.82
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While slice-to-volume registration and super-resolution reconstruction laid the foundation for motion-corrected 3D T2-weighted fetal brain magnetic resonance imaging (MRI) more than two decades ago, advances in deep learning are now enabling automation across …
pubmed
Luis A, Uus A, Story L, Rutherford M
2026 Aug 24
置信度 0.82
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Marburg virus disease (MVD) is a highly lethal filovirus infection with case fatality rates of up to 88%. Although no virus-specific interventions have yet been approved, recent laboratory breakthroughs have markedly accelerated translational progress in vacci…
pubmed
Kandi V, Branda F, Alissa M, Pattnaik G 等
2026 Aug 24
置信度 0.82
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Neonatal extraintestinal pathogenic Escherichia coli (ExPEC) severe threat to newborn health. O antigen is a highly variable component of lipopolysaccharide, serves as the main phenotypic marker for serotyping, and represents a promising target for vaccination…
pubmed
Zhang D, Zou P, Xiao R, Li J 等
2026
置信度 0.82
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Broad health concepts are increasingly embedded in healthcare and other domains. Therefore, in a previous study, we developed and validated the Context-Sensitive Positive Health Questionnaire (CPHQ). The CPHQ is based on Positive Health, the Capability Approac…
pubmed
Boelens M, Roumen C, Bloemen-van Gurp EJ, Dierx J 等
2026
置信度 0.82
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Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. POTS can substantially impair daily function…
pubmed
Chung TH, Raj SR
2026 Aug 24
置信度 0.82
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Naturally occurring in animals, plants, and other organisms, peptides exhibit strong antibacterial activity and hold promise as alternatives to conventional antibiotics. However, evaluating peptide properties such as toxicity, antibacterial activity, and antic…
pubmed
Wu H, Deng Y, Li Z, Qi M 等
2026 Aug 24
置信度 0.82
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Adrenal and extra-adrenal paragangliomas (PPGLs) are highly heritable non-epithelial neuroendocrine neoplasms. Through a retrospective chart review of 110 individuals diagnosed with PPGLs at the University Health Network in Toronto, Canada (2011-2023), we char…
pubmed
Purnaghshband H, Tuzlali E, Deka KB, Bruce JP 等
2026 Aug 24
置信度 0.82
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Immune checkpoint inhibitors (ICIs) have become an important therapeutic option for oral cancers; however, reliable biomarkers predicting treatment efficacy remain limited. In this study, we investigated the association between intratumoral immune cell subsets…
pubmed
Yamashita M, Yano H, Komohara Y, Yamada R 等
2026 Aug 24
置信度 0.82
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Socioenvironmental adversities play an important role in psychosis aetiology, yet the pathways that link them to psychosis development remain poorly understood. This qualitative study explored how individuals with early psychosis make sense of psychosis its em…
pubmed
Both AP, Xavier SM, van den Bogerd N, Salmanova AR 等
2026 Aug 24
置信度 0.82
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The growing demand for sustainable and nutritionally adequate protein sources has intensified interest in alternative plant proteins capable of supporting future food systems. However, many conventional plant proteins still present limitations related to aller…
pubmed
Meza SLR, Rodrigues LA, Medina S, Egea I 等
2026 Aug 24
置信度 0.82
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Major trauma can have a long-term impact, leading to diminished health-related quality of life (HRQoL) for patients and their significant others (SOs). Patient reported outcome measures (PROMs) make this impact visible, providing expectation- and self-manageme…
pubmed
Van Ditshuizen JC, Berg LVD, Verhofstad MHJ, Leliefeld PHC 等
2026 Aug 24
置信度 0.82
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Adolescents and young adults (AYAs) aged 15-39 with cancer face distinct challenges during treatment, with eating consistently emerging as one of the most distressing and underrecognized concerns. At a critical life stage, AYAs must navigate illness-related co…
pubmed
Christensen ME, Jónsdóttir RB, Skúladóttir SS, Klinke ME
2026 Oct
置信度 0.82
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The growing demand for precise and effective gene therapy has driven the extensive exploration of nucleic acid therapeutics. DNAzymes are catalytically active single-stranded DNA molecules with high programmability and substrate-recognition specificity, and th…
pubmed
Li Y, Sun H, Han M, Jia J 等
2026 Aug 24
置信度 0.82
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Epidemiologic estimates for age of systemic lupus erythematosus (SLE) diagnosis are limited, particularly for men and racial and ethnic subpopulations in the United States. Leveraging the Centers for Disease Control and Prevention (CDC) National Lupus Registry…
pubmed
Izmirly PM, Ferucci ED, Hersh AO, Son MB 等
2026 Aug 24
置信度 0.82
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Cation channels regulate diverse physiological processes, and their dysregulation is implicated in cancer, cardiovascular diseases, and neurological disorders. Although several cation channel modulators are clinically used, their efficacy is often limited by t…
pubmed
Hu H, Lin Y, Lv J, Liang Z 等
2026 Aug 24
置信度 0.82
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Although lumen formation is a key feature of organogenesis, luminal compartments - formed through the secretion of fluid, ions and macromolecules by the cells, usually on the apical side - are often viewed as passive by-products of epithelial polarity. Here, w…
pubmed
Lee BH, Mukenhirn M, Guyomar T, Maggipinto Y 等
2026 Aug 15
置信度 0.82