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• Integrative Oncology à La Française. Evolution and Distinctive Features.
  Integrative Oncology (IO) in France aligns with the definition proposed by the Society for Integrative Oncology, combining conventional cancer treatments with evidence-based complementary therapies within an interdisciplinary, patient-centered framework. Unlik…
  pubmed Mastroianni B, Forissier V, Bagot JL 2026 Jan-Dec 置信度 0.82
• The cysteine protease PAI1 acts as a quantitative metabolic coordinator of amino acid flux for pollen maturation and anther dehiscence in rice.
  The coordination of pollen maturation and anther dehiscence is essential for cereal fertility, yet the metabolic mechanisms linking these processes remain poorly understood. Here, we demonstrate that the rice cysteine protease PAI1 (Pollen Anther Integrator 1)…
  pubmed Tian J, He J, Xu Y, Bao J 等 2026 Aug 28 置信度 0.82
• Patient-Reported Outcome Measures and Self-Management Strategies to Promote Health in Higher-Education Classical Music Performance Students: A Delphi Study.
  Students in classical music performance in higher education frequently report playing-related musculoskeletal disorders (PRMDs) and psychological distress. Observational studies based on self-reported data suggest an association between these two health proble…
  pubmed Tharin F, James CE, Bruyneel AV 2026 Aug 28 置信度 0.82
• Successful Therapeutic Plasma Exchange in Refractory Anti-MDA5-Positive Dermatomyositis and Rapidly Progressive-Interstitial Lung Disease: A Case Report.
  Anti-MDA5-positive clinically amyopathic dermatomyositis (CADM) is closely linked to rapidly progressive-interstitial lung disease (RP-ILD) and is associated with high mortality rates. This report discusses a 60-year-old female patient diagnosed with anti-MDA5…
  pubmed Balkan B, Kaya E 2026 Aug 28 置信度 0.82
• Social Media Use and Cardiovascular Health Among US High School Students.
  Cardiovascular health during adolescence can shape cardiovascular disease risk later in life. We examined the association between frequent social media use and cardiovascular health among US high school students.
  pubmed Saelee R, McKinnon II, Kiplagat SJ, Rumph JT 等 2026 Aug 28 置信度 0.82
• Beyond the Fracture Clinic: 3 Things a Surgeon Can Do to Help Older Patients Stay Out of the Hospital.
  Musculoskeletal conditions, particularly osteoarthritis, account for >40 million disability-adjusted life years worldwide among persons aged 60 years and above. Research has also demonstrated that up to half of older adults have multimorbidity, which requir…
  pubmed Ziebart C, Heckman G, Giangregorio LM, Jiwa F 等 2026 Aug 28 置信度 0.82
• Transglutaminase 2 regulates vimentin-dependent proteostasis during macrophage activation.
  Sepsis-associated liver dysfunction is a life-threatening condition with a high mortality rate and no mechanism-based therapy. In this study, we identify the cross-linking enzyme transglutaminase 2 (TG2) as a driver of liver inflammation by activating macropha…
  pubmed Xu Y, Su T, Mishra H, Dohmae N 等 2026 Aug 28 置信度 0.82
• SpotMAX: A generalist framework for multidimensional automatic spot detection and quantification.
  The analysis of spot-like structures is a widespread task in microscopy image analysis. Existing solutions are typically specific to single applications and do not use multidimensional information, often leaving manual annotation as the only option. Here, we p…
  pubmed Padovani F, Čavka I, Neves ARR, López CP 等 2026 Aug 28 置信度 0.82
• The structure of the dopamine D(3) receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.
  The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D 3 receptor (D 3 R). Here, we report the cryo-electron microscopy structure of cariprazine bound to D 3 R, establishing a framework for understanding ligand recog…
  pubmed Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K 等 2026 Aug 28 置信度 0.82
• O-Glycosylated expansin ThSWO condensates drive Trichoderma harzianum attachment to rice root during the colonization process.
  Expansins and lectins facilitate microbial colonization, but their collaborative mechanisms across different colonization stages remain unclear, and fungal root attachment via these proteins requires further exploration. This study proposes a fungal early colo…
  pubmed Chen C, Shi X, Zhu H, Wang T 等 2026 Aug 28 置信度 0.82
• scProtoTransformer: Scalable reference mapping across molecules, cells, and donors.
  The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current r…
  pubmed Tang Z, He H, Chen S, Zhu J 等 2026 Aug 28 置信度 0.82
• SHARPIN restrains IL-33 release by stromal cells to control ILC2 inflammation.
  Loss of SHARPIN, a component of the linear ubiquitin chain assembly complex (LUBAC), causes systemic inflammation including the accumulation of eosinophils across multiple tissues in mice. However, the mechanisms by which SHARPIN regulates type 2 inflammation …
  pubmed Zeng P, Mao X, Zhang W, Li J 等 2026 Aug 28 置信度 0.82
• Mental bootstrapping enables human-level concept learning in self-supervised deep models.
  How agents acquire abstract concepts from sparse, diverse examples-often without explicit supervision-remains a central problem in cognitive science and artificial intelligence. Human studies suggest that this ability depends on mental bootstrapping, the gradu…
  pubmed Yang L, Lyu M, Wang YJ, Xie X 等 2026 Aug 28 置信度 0.82
• Two bHLH transcription factors regulate PbGME1 expression to modulate ascorbate biosynthesis and salt tolerance in pear.
  Salt stress severely limits plant growth and productivity. GDP-mannose-3',5'-epimerase (GME), a key enzyme in ascorbic acid (AsA) biosynthesis, has been implicated in plant stress responses, but its role in pear salt tolerance remains unclear. Here, we identif…
  pubmed Dong H, Ma M, Liu C, Yu C 等 2026 Aug 4 置信度 0.82
• Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.
  Mitochondria catabolize nutrients by generating sequentially-ordered organic acid intermediates that are oxidized through the tricarboxylic acid cycle. Pathogenic accumulation of metabolic organic acids manifests as devastating organic acidemias/acidurias and …
  pubmed Zhang J, Shan Q, Wang X, Li M 等 2026 Aug 28 置信度 0.82
• Wild edible plants of Bhutan: Diversity, use patterns, and motivations for consumption.
  Wild edible plants (WEPs) have long supported rural livelihoods and cultural practices in Bhutan, yet their use and associated knowledge are increasingly challenged by agricultural change, modernization, and limited documentation. This study documented the div…
  pubmed Jamtsho T, Tobgay, Takchu U, Wangchuk P 2026 置信度 0.82
• Metal binding site alignment enables network-driven discovery of recurrent geometries across sequence-divergent proteins and drug off-targets.
  Metal-binding sites (MBSs) are critical determinants of protein stability and biological function, yet methods for comparing their local binding environments lag behind those for whole-structure alignment. Here, we represent MBSs as atomic point clouds surroun…
  pubmed Simensen V, Almaas E 2026 Aug 置信度 0.82
• Coming of Age With Generative Artificial Intelligence: The High Stakes of Automating Adolescent Development.
  Generative artificial intelligence (GenAI) is rapidly transforming the context in which adolescents develop, presenting both opportunities and risks. Adolescence is a sensitive life period during which the accomplishment of key psychosocial developmental tasks…
  pubmed Maheux AJ, Maes C 2026 Aug 28 置信度 0.82
• Cropland type shapes arbuscular mycorrhizal fungi (AMF) population density and species diversity in Northwest Ethiopia.
  AMF play critical function in soil fertility and plant nutrition, especially in absorption and translocation of immobile nutrients. Farm and soil fertility management activities enhance crop yield; however, they either positively or negatively impact the AMF p…
  pubmed Kassew D, Yimer J, Pagano MC, Assefa F 等 2026 置信度 0.82
• ASPIRE: Accurate alternative splicing prediction from limited RNA sequencing data and a minimal gene set.
  Alternative splicing is a fundamental biological mechanism that increases protein diversity and regulates critical cellular processes across eukaryotes. Dysregulation of splicing is implicated in a wide range of diseases, including cancer, neurological disorde…
  pubmed Eisenberg R, Rahamim E, Kopel E, Danan-Gotthold M 等 2026 Aug 28 置信度 0.82
• A cross‑sectional analysis of vitamin D status and associated factors in children recovering from severe acute malnutrition in Zambia and Zimbabwe.
  Mortality following severe acute malnutrition (SAM) remains high in Africa. Some children with SAM have altered immune responses and impaired neurodevelopment; however, whether vitamin D deficiency contributes to these poor outcomes remains unclear. We conduct…
  pubmed Phiri TN, Dumbura C, Mutasa K, Ngosa D 等 2026 置信度 0.82
• Ecological theory sheds light on plasmid diversity and dynamics.
  Bacterial genomes are remarkably dynamic, shaped by horizontal gene transfer. Plasmids are key actors in this process, fueling rapid bacterial adaptation to stresses such as antibiotics. Yet, plasmids follow evolutionary trajectories of their own, defying trad…
  pubmed Tuffet R, Acacia E, Coluzzi C, Charpentier X 等 2026 Aug 置信度 0.82
• Identification of novel peripherally restricted risperidone-like dopamine D2 receptor antagonists for prolactin-mediated neuroprotection through a multi-stage in silico screening.
  Prolactin, a hormone with emerging neuroprotective roles, has demonstrated potential in mitigating cognitive impairment under specific neurotoxic conditions, including environmental toxicity and excitotoxicity. While dopamine D2 receptor (D2R) antagonists, suc…
  pubmed Kim S, Jo WH, Cha JO, Kim MS 2026 置信度 0.82
• Exploration of acetylation-related biomarkers in osteoarthritis through bioinformatics analysis.
  Osteoarthritis (OA) is characterized as a chronic degenerative disorder affecting the joints. A growing body of evidence indicates that acetylation may play a role in the disease's pathogenesis. However, the underlying molecular mechanisms remain largely undef…
  pubmed Li S, Yin J, Huang J, Zheng X 等 2026 置信度 0.82
• Equine influenza virus at 70: What horses taught us about flu.
  pubmed Mojsiejczuk L, Chambers TM, Murcia PR 2026 Aug 置信度 0.82
• "One less thing to worry about": Barriers and facilitators of PrEP uptake among MSM in Karachi, Pakistan: A qualitative study.
  In Pakistan, MSM represent one of the key populations at risk of HIV, with rising rates of HIV compared to the general population and other key populations. Pre-exposure prophylaxis (PrEP) was rolled out in Pakistan in two of the most populated provinces, Sind…
  pubmed Fatima B, Soomar S, Katyara P, Batool S 等 2026 置信度 0.82
• Prevalence of mental health, mental well-being, and school connectedness in UK secondary school students in 2021/2022: Results from the South West - School Health Research Network pilot study.
  Young people are experiencing more mental health challenges, and connection to school can improve this. This study aimed to investigate adverse mental health, mental well-being, and school connectedness among secondary school students according to gender, acad…
  pubmed Albers PN, Widnall E, Hatch L, Hopkins G 等 2026 置信度 0.82
• Colorectal Centre of Excellence (COCOE) Registry: A protocol for a prospective longitudinal cohort of children with Hirschsprung's disease and anorectal malformations in Canada.
  Hirschsprung's disease (HD) and anorectal malformations (ARM) are congenital colorectal conditions requiring lifelong multidisciplinary care, yet no prospective, longitudinal registry exists for affected children in Canada. We describe the protocol for the COC…
  pubmed Hill L, St-Louis É, Dandavino M, Korah N 等 2026 置信度 0.82
• Machine learning-based classification model to distinguish tumor and tumor-free samples using synthetic plasma proteomic dataset.
  Tumor-Specific Peptides (TSPs) and Tumor-associated Overexpressed Proteins (TOPs) are promising biomarkers for cancer diagnosis and monitoring. TSPs arise from somatic mutations unique to tumor cells. Their detection in plasma through mass spectrometry-based p…
  pubmed Feizyab S, Bonetti G, Macchia A, Donato K 等 2026 Sep-Oct 置信度 0.82
• Trophic regulation constrains ecosystem carbon accumulation under global change.
  Global change is rapidly reshaping the ecosystem carbon cycle, yet how trophic regulation-a fundamental driver of ecosystem biogeochemical cycling-mediates these responses remains poorly understood. Here we present a global synthesis of interactions between tr…
  pubmed Xu C, Malhi Y, Li X, Ao G 等 2026 Sep 置信度 0.82
• Rethinking the origin of life at seafloor hydrothermal vents.
  Alkaline vents have dominated a class of hypotheses for the origins of life since their discovery a quarter of century ago, but advances in understanding the nature of these systems at the time of life's origins demand renewed scrutiny. Alkaline vent hypothese…
  pubmed Tutolo BM 2026 置信度 0.82
• Tuning Rectification and Gating in Biological Nanopores Through Lumen Charge Mutation.
  β-barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to antibiotic resistance in Gram-negative bacteria, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion…
  pubmed Mayer SF, Mitsioni MF, Marcaida MJ, Emmerich T 等 2026 置信度 0.82
• Biomechanics of Rugby Tackle Techniques in Youth and Adult Players: A Systematic Review of Age-Specific Injury Risk and Performance Implications.
  Tackling is a vital skill in rugby that greatly influences both performance outcomes, such as carry distance and possession gain, and injury risk, such as the frequency of concussions and cervical injuries. Approximately 72% of head impacts in rugby occur duri…
  pubmed Edgington HCA, Liew BXW, Hendricks S, Jones B 等 2026 Aug 28 置信度 0.82
• Influence of LGALS3 polymorphisms on chemotherapy-induced peripheral neuropathy in patients with metastatic pancreatic cancer treated with gemcitabine and nab-paclitaxel: an exploratory biomarker analysis of the GENESECT study.
  Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting factor and determinant of treatment continuation in patients receiving anticancer drugs. CIPN often persists even after treatment discontinuation and negatively impacts patients' quality of l…
  pubmed Hatori M, Tsuji D, Nagai K, Arafune R 等 2026 Aug 28 置信度 0.82
• Preventable maternal and neonatal factors of early and late neonatal mortality in rural city of Tshumbe, Sankuru Province, Democratic Republic of the Congo.
  The first 28 days of life, known as the neonatal period, is most vulnerable time for child's survival. Prematurity, infections, and respiratory distress are the most important causes of neonatal death.
  pubmed Mbelambela EPS, Mbutshu OMC, Villanueva AF, Tokoko OD 等 2026 Aug 28 置信度 0.82
• The outcomes of surrogate pregnancy using donor egg compared to surrogate's egg: a systematic review.
  Surrogacy is either gestational (GS) using donor egg or traditional (TS) using surrogate's own egg. GS is increasing, partly from assumptions over less difficulty in transferring the baby to intended parents. This systematic review investigates obstetric outco…
  pubmed Barry P, Choong E, Meads C, Bewley S 2026 Aug 28 置信度 0.82
• Real-World Effectiveness and Safety of Bimekizumab for Moderate-to-Severe Hidradenitis Suppurativa: A Multicenter Retrospective Study from the Italian Landscape HS (IL-HS).
  Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, draining tunnels and substantial impairment in quality of life. Bimekizumab, a monoclonal antibody that selectively inhibits interleukin-17A and i…
  pubmed Valenti M, Ingurgio RC, Ibba L, Cammarata E 等 2026 Aug 28 置信度 0.82
• Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood-Brain Barrier Integrity in a Rat Model of Iron Overload.
  Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that excessive iron during early postnatal life induces oxidative rea…
  pubmed Kowalski L, Colucci ACM, Dos Santos JB, Vuaden BW 等 2026 Aug 28 置信度 0.82
• The Arlington study of healthy aging: a multidisciplinary community cohort study of functional decline with age.
  The planet is experiencing an unprecedented growth in its human population aged 65 years and older, underscoring the urgent need for comprehensive aging-centered biobehavioral data to guide public health interventions. The Arlington Study of Healthy Aging…
  pubmed Davis DL, Shah R, Pixler L, Mai DM 等 2026 Aug 28 置信度 0.82
• Cognitive vergence and pupillary responses as functional oculomotor signatures to differentiate AT(N) biological profiles in older adults with mild cognitive impairment.
  The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer's disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alz…
  pubmed Martínez-Flores R, Martín-Sobrino I, Falgàs N, Grau-Rivera O 等 2026 Aug 28 置信度 0.82
• Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group.
  Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinical…
  pubmed Tašková I, Gittins R, Riesenhuber N, Stuhec M 等 2026 Aug 28 置信度 0.82
• Correction: Unveiling the role of CB2 receptor in beta-hydroxybutyrate mediated modulation of microglial anti-inflammatory phenotype.
  pubmed Iešmantaitė M, Usonis L, Čeika K, Šimoliūnas E 等 2026 置信度 0.82
• Potential of pongam oil and karanjin as natural nitrification inhibitors: mechanistic effects on nitrifying microorganisms and soil nitrogen transformation.
  Nitrification inhibitors delay the microbial oxidation of ammonium to nitrate, thereby improving nitrogen use efficiency and reducing nitrate losses and nitrous oxide emissions from fertilized soils. Although synthetic inhibitors such as dicyandiamide (DCD) ar…
  pubmed Chepyala S, Vemuri PK, Nasam MK, Bathula J 等 2026 Aug 28 置信度 0.82
• AMPKγ2-Myosin Interaction: A Glycogen-Independent Trigger for PRKAG2 Cardiomyopathy.
  pubmed Song J, Zhu Y, Lin Y, Bei Y 2026 置信度 0.82
• Complete telomere-to-telomere genome assembly of Guazuma ulmifolia uncovers evolutionary mechanisms, drought adaptation, and flavonoid biosynthesis.
  The first T2T reference genome of Guazuma ulmifolia is reported, which serves as a core genomic resource for stress adaptation research and stress-tolerant breeding in cacao wild relatives. Climate change, particularly increased incidence of drought, poses a m…
  pubmed Dorjee T, Cui Y, Liu B, Richardson JE 等 2026 Aug 28 置信度 0.82
• Xanthium strumarium L. extract attenuates TNF-α/IFN-γ- stimulated inflammation and promotes hyaluronan production on HaCaT keratinocytes.
  Xanthium strumarium L. has traditionally been used for inflammatory disorders; however, its molecular effects on keratinocyte inflammation and hyaluronan metabolism remain poorly understood. This study evaluated the modulatory trends of X.strumarium L. extract…
  pubmed Purevdorj J, Lee HJ, Justine EE, Lee JE 等 2026 Aug 28 置信度 0.82
• Delayed hatching as a life-history response to intraguild predation: interspecific variation in predatory mites.
  When and why embryos delay hatching in response to predation risk remains poorly understood, particularly across species experiencing different ecological contexts. Predator-induced hatching plasticity allows embryos to adjust hatching timing in response to pr…
  pubmed Furukawa T, Sato Y 2026 置信度 0.82
• Immersive head-mounted control of a robotic laparoscopic camera: a usability and accuracy evaluation.
  Robotic surgery has addressed limitations of minimally invasive surgery, namely: assistant hand tremors during camera holding and communication errors among team members. However, advanced systems require substantial investment and operating-room space. As a r…
  pubmed Pereira SG, Morais P, Rocha F, Osório NS 等 2026 Aug 28 置信度 0.82
• Dry bulb mite Aceria tulipae (Acariformes: Eriophyidae) on garden garlic (Allium sativum): new insights into distribution and control methods in Ukraine.
  The dry bulb mite Aceria tulipae is one of the most economically important pests of Allium crops worldwide, damaging plants during vegetation and bulb storage. Despite its increasing phytosanitary importance, information on the distribution and management of A…
  pubmed Bondareva LM 2026 Aug 28 置信度 0.82
• Genome characterization of two novel mitoviruses and a negative-sense single-stranded RNA mycovirus from the phytopathogenic fungus Clarireedia jacksonii.
  Clarireedia jacksonii is a phytopathogenic fungus responsible for dollar spot disease in turfgrass worldwide. In this study, we characterized the complete genome sequences of three novel mycoviruses isolated from C. jacksonii isolate MBCT-836 using next-genera…
  pubmed Sakuta K, Mabuchi T, Urayama SI, Netsu O 等 2026 Aug 28 置信度 0.82
• Occurrence, temporal variation, and meteorological drivers of airborne fungal spores in Laoag City, northern Philippines.
  Airborne fungal spores are major constituents of atmospheric bioaerosols that influence environmental exposure, ecosystem processes, and respiratory health. Despite their ecological and public health significance, long-term outdoor monitoring data describing t…
  pubmed Llorando AM, Bennett RM, Sabit MB 2026 Aug 28 置信度 0.82
• Effects of temperature on the development and reproduction of Macrocheles nataliae.
  Macrocheles nataliae (Acari: Macrochelidae) holds promise as a biological control of soil-inhabiting pests. Temperature is a critical abiotic factor influencing the population dynamics and biocontrol efficacy of predatory mites. However, its effects on the dev…
  pubmed Liu W, Zeng Z, Ji J, Ruan C 等 2026 Aug 28 置信度 0.82
• Identification and characterization of a Nervous Necrosis Virus (NNV) isolated from tilapia (Oreochromis niloticus) in China.
  Nervous necrosis virus (NNV) is a viral pathogen that infected variety of cultured and farmed fish around the world. In this study, we isolated a novel NNV from diseased cultured tilapia (Oreochromis niloticus). The typical vacuolates were discovered in the br…
  pubmed Yu D, Weng T, Xia H, Xia L 等 2026 Aug 28 置信度 0.82
• Study on the molecular mechanism of interaction between brominated flame retardants and human serum albumin by molecular docking.
  With the extensive application of brominated flame retardants (BFRs) in industry and daily life, their potential impact on human health has gradually drawn attention. This study utilized molecular docking, supplemented by molecular dynamics (MD) simulations, t…
  pubmed Ci C, Liao Z, Fu J, Luo Y 等 2026 Aug 28 置信度 0.82
• Unveiling the interactions between design optimization, modeling strategies, and spatial analysis in genomic selection.
  Partially-replicated designs are more efficient than fully-replicated ones. They can be further enhanced through optimization and present positive synergy with fully-efficient models and 2D P-splines. In plant breeding, traditional field trials rely on balance…
  pubmed Fernández-González J, Comadran Trabal J, Haquin B, Allard A 等 2026 Aug 28 置信度 0.82
• Social deprivation weakens sender-receiver coupling in mother-infant acoustic communication by altering pup vocal development in Mongolian gerbils (Meriones unguiculatus).
  In rodent pups, ultrasonic vocalizations (USVs) are thought to function as contact signals in mother-infant communication, but it remains unclear whether early disruption of the social environment alters their communicative effectiveness. Using the Mongolian g…
  pubmed Nishibori R, Kinoshita Y, Matsumoto N, Nakagawa H 等 2026 Aug 28 置信度 0.82
• Approximating prediction error variances and reliabilities in a multiple-trait genomic prediction model using Monte Carlo sampling.
  We evaluated four existing Monte Carlo-based methods for approximating prediction error variances and reliabilities in a multiple-trait genomic prediction model. All four methods yielded consistent approximations of the exact values. Genomic prediction models,…
  pubmed Heikkilä A, Strandén I, Lidauer MH, Nordhausen K 等 2026 Aug 28 置信度 0.82
• Methods for assessing core muscle co-activation in the lumbar region: a narrative review.
  Core muscle co-activation is a key neuromuscular mechanism for lumbar spine stability, and its quantitative assessment is important for understanding spinal control, identifying dysfunction, guiding rehabilitation, and informing injury prevention. This narrati…
  pubmed Ding L, Li M, Xu J, Weldon A 等 2026 Aug 28 置信度 0.82
• Brain activity alterations following lumbar discectomy in people with chronic low back pain.
  Chronic low back pain (CLBP) remains a major clinical and socioeconomic challenge, particularly among individuals who continue to experience pain following lumbar discectomy. Despite advances in imaging and treatment, the neural mechanisms underlying persisten…
  pubmed Salamat S, Abdollahzade Z, Talebian S, Bastani A 等 2026 Aug 28 置信度 0.82
• Nasal Nitric Oxide as a Novel Biomarker for Assessing Risk of Impaired Neurodevelopment in Infants and Newborns with Congenital Heart Disease.
  Nasal nitric oxide (nNO) is a non-invasive marker for predicting the risk of neurodevelopmental delays. We investigated whether nNO in infants with CHD undergoing congenital cardiac surgery could serve as a biomarker for assessing the risk of impaired neurodev…
  pubmed Powers E, Tien A, Lorenzi-Quigley L, Lo CW 等 2026 Aug 28 置信度 0.82
• Is the cervical bone a biological marker for bone age assessment?
  Age assessment is essential in forensic practice when the chronological age of living individuals is unknown, particularly in legal, civil, migration, and asylum contexts requiring the judicial determination of age-related rights and responsibilities. This stu…
  pubmed Pereira CP, Bonvini R, Santos R, Vanin S 等 2026 Aug 27 置信度 0.82
• Unequal Embodiment: Racial and Ethnic Heterogeneity in the Predictors and Age-Related Health Outcomes Associated with Accelerated Biological Aging.
  This study investigates whether life-course socioeconomic exposures are similarly associated with accelerated biological aging across racial and ethnic groups, and whether accelerated biological aging predicts health outcomes equivalently across groups.
  pubmed Villalba Madrid M, Ríos Casas F, Farina MP 2026 Aug 28 置信度 0.82
• Fall-related injuries in long-term oxygen therapy: Incidence and predictive factors.
  Fall-related injuries are a common cause of morbidity and impaired quality of life among patients with severe respiratory disease. Use of long-term oxygen therapy (LTOT) may be associated with a further increased risk.
  pubmed Björklund F, Palm A, Sundh J, Ekström M 2026 Aug 28 置信度 0.82
• A novel SUR1-TMD0 interaction region contributes to glucose-dependent inhibition of pancreatic K(ATP) channels by bupropion.
  Pancreatic β-cell ATP-sensitive potassium (K ATP ) channels play a central role in glucose homeostasis by coupling cellular metabolism to insulin secretion. Although conventional K ATP channel inhibitors are effective insulin secretagogues, their clinica…
  pubmed Matsuoka W, Suzuki M, Murao N, Hidema S 等 2026 Aug 28 置信度 0.82
• A feasibility study of a new version of self-practice/self-reflective (SP/SR) groupwork for cognitive behaviour therapy training.
  Clients receiving cognitive behaviour therapy (CBT) may disengage from therapy for different reasons, including limited self-awareness and interpersonal skills among the modifiable therapist factors. In this feasibility study, we evaluated recruitment, retenti…
  pubmed Walker N, Gibson B, Emerson J, de Geeter D 等 2026 Aug 28 置信度 0.82
• Health, social and economic impacts of the UK Treasury Soft Drinks Industry Levy: a synopsis of a systems-thinking informed multi-method evaluation.
  In March 2016, a tiered tax was announced on industries manufacturing or importing sugar-sweetened beverages in the United Kingdom. The Soft Drinks Industry Levy was implemented in April 2018 with two tiers: £0.18/l on drinks containing ≥ 5&…
  pubmed Jones CP, Adams J, Scarborough P, Smith R 等 2026 Aug 置信度 0.82
• Environmental microbial community signatures associated with Listeria spp. detection in German meat processing facilities.
  Listeria monocytogenes can persist in niches of meat processing environments despite routine cleaning and disinfection. Its persistence may depend not only on stress tolerance but also on interactions with resident microbial communities, which may promote or i…
  pubmed Braun J, Wildi N, Kovac J, Guldimann C 2026 Aug 28 置信度 0.82
• Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide.
  Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monoo…
  pubmed Zhang X, Li L, Lu Z, Duan C 等 2026 Aug 28 置信度 0.82
• Genomes of cressdnaviricots and phixviricots in a freshwater lake sample from Arizona, USA.
  A viral metagenomic analysis of a 40 ml water sample from a small freshwater lake near Flagstaff, Arizona, USA, resulted in the identification of 295 circular viral genome sequences. Of these, 126 are members of Cressdnaviricota and 169 of Phixviricota phyla.
  pubmed Custer JM, Kraberger S, Levi G, Schmidlin K 等 2026 Aug 28 置信度 0.82
• Light-induced carotenogenesis enhances growth and high hydrostatic pressure tolerance in a deep-sea bacterium by reducing intracellular ROS.
  Deep-sea hydrothermal vents emit geothermal light, yet its ecological role in shaping microbial adaptation remains largely unexplored. To investigate this, we designed a custom cultivation system that simultaneously applies high hydrostatic pressure (HHP) and …
  pubmed Lin J, Li X-G, Zhang W-J, Fang H-R 等 2026 Aug 28 置信度 0.82
• Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness.
  Polycystic ovary syndrome (PCOS), recently renamed as polyendocrine metabolic ovarian syndrome (PMOS), is a prevalent endocrine disorder in women, often accompanied by various symptoms, including significant pain, such as dysmenorrhea, abdominal, and pelvic pa…
  pubmed Cherlin T, Mohammed S, Strydesky S, Ottey S 等 2026 Aug 28 置信度 0.82
• MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts.
  Transcription factors of the MIT/TFE family-mitfa, mitfb, and tfec-play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundan…
  pubmed Lister J, Sugiwaka K, Kimura T, Tanaka R 等 2026 Aug 28 置信度 0.82
• Machine Learning-Driven Risk Prediction Model in Transthyretin Amyloid Cardiomyopathy.
  Transthyretin cardiac amyloidosis (ATTR-CM) is associated with poor prognosis and significant morbidity and mortality, yet existing staging systems have limited ability to accurately predict outcomes in contemporary patient populations.
  pubmed Baj G, Ciocca N, Mohammadi Kazaj P, Ma X 等 2026 Aug 28 置信度 0.82
• Effect of Sleep, Sleep Apnoea and Insomnia Symptoms on Depressive Symptoms in Combined harmonised Community-Based Cohorts-A Cross-Sectional Analysis.
  Sleep and sleep disturbances, such as sleep apnoea and insomnia, are linked to mental health, particularly, depressive symptoms. It remains unclear however, if sleep fragmentation or hypoxia is primarily linked to depressive symptoms and how insomnia symptoms …
  pubmed Theorell-Haglöw J, Wittert GA, Adams RJ, Appleton SL 等 2026 Aug 28 置信度 0.82
• Cognitive Function and Telemedicine-based, Village Doctor-led Care for Atrial Fibrillation.
  Cognitive impairment is common among older patients with atrial fibrillation (AF). We aimed to evaluate whether baseline cognitive function modifies the effectiveness of a telemedicine-based, village doctor-led integrated care in older patients with AF.
  pubmed Li M, Chen Y, Zhang S, Chu M 等 2026 Aug 28 置信度 0.82
• Oxygenaging: A Physiological Framework for Geroscience.
  The stepwise movement of oxygen from the atmosphere to the mitochondria, the "oxygen cascade", is one of the most tightly regulated systems in physiology. Despite decades of mechanistic study, it has remained quite unexplored in Geroscience. This oversight sho…
  pubmed Donega S, Fishbein KW, Dominelli P, Herman AB 等 2026 Sep 置信度 0.82
• Decompressive craniectomy versus craniotomy for patients undergoing surgical evacuation of an acute subdural hematoma: RESCUE-ASDH RCT and cost effectiveness.
  Traumatic acute subdural haematomas often require surgical evacuation via craniotomy or decompressive craniectomy. Decompressive craniectomy may prevent intracranial hypertension; however, it is unclear whether it is associated with better outcomes.
  pubmed Hutchinson P, Mee H, Adams H, Mohan M 等 2026 Aug 置信度 0.82
• Clinical impact of nociplastic symptom burden in individuals with fibromyalgia syndrome.
  The clinical impact of nociplastic pain symptoms has not yet been sufficiently investigated.
  pubmed Akin E, Saracoglu I, Calik BB, Cobankara V 2026 Aug 28 置信度 0.82
• Women's Causal Beliefs About Their Pelvic Pain: A Systematic Review and Meta-Ethnography.
  This study identified and synthesized the current qualitative literature on women's causal beliefs about their chronic pelvic pain.
  pubmed Ferencz GA, Mardon AK, Mitchell AM, Kumar S 等 2026 Sep 置信度 0.82
• A Media Analysis of Debates on Extended Alcohol Trading Hours Changes in Scotland.
  Between 2017 and 2019, different policy processes in two large Scottish cities led to local authorities granting licences for later on-premises alcohol trading hours. As a part of a wider mixed methods study, we examine news media reporting of these licencing …
  pubmed Cook M, O'Donnell R, Mitchell G, Maxwell KJ 等 2026 Sep 置信度 0.82
• Genetic Risk of Cardiovascular Disease Among People With No Standard Modifiable Risk Factors.
  pubmed Farah R, Sui Y, Jemma Cho SM, Natarajan P 等 2026 Aug 28 置信度 0.82
• Sex-Specific Differences in Patient-Centered Outcomes After Transcatheter Aortic Valve Replacement.
  Sex-specific disparities in patient-reported outcomes among patients undergoing transcatheter aortic valve replacement (TAVR) are not fully investigated.
  pubmed Tomii D, Lanz J, Heg D, Cozzi O 等 2026 Aug 13 置信度 0.82
• Genetically Mediated Differences in LDL Cholesterol and Risk of Venous Thromboembolism.
  Venous thromboembolism (VTE) is a common and clinically significant cardiovascular condition. Although low-density lipoprotein (LDL) cholesterol is causally linked to atherosclerotic disease, its role in VTE remains unclear. Meta-analyses of randomized trials …
  pubmed Sui Y, Kany S, Khurshid S, Supriami K 等 2026 Aug 4 置信度 0.82
• Reply to "Does disease ontogeny matter more than JAK2 mutation status in acute myeloid leukemia?".
  pubmed Albliwi M, Nurse DP, Zabor EC, Hanna J 等 2026 Sep 1 置信度 0.82
• SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells.
  Peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcriptional regulator of genes mediating adipogenesis (fat-cell differentiation), and lipid storage in several cell types like hepatocytes. As such, its regulation is crucial for cell …
  pubmed Nashnaz N, Goldberg D, Abramov M, Chopra A 等 2026 Aug 28 置信度 0.82
• Rheumatoid arthritis flares and de novo inflammatory arthritis after immune checkpoint inhibitor therapy: a single-center exploratory study of clinical phenotypes.
  Immune checkpoint inhibitors (ICIs) can cause de novo inflammatory arthritis and flares of pre-existing rheumatoid arthritis (RA). This study aimed to describe and explore the clinical characteristics and treatment outcomes of these arthritis groups in a singl…
  pubmed Kachi S, Shirakashi M, Nomura M, Nakayama Y 等 2026 Aug 28 置信度 0.82
• Individual Participant Data Meta-Analysis (IPDMA) of long-term COVID-19 outcomes in a systematic review-informed, international, multidisciplinary database.
  Identifying and addressing long-term health and societal challenges after COVID-19 is a research priority.
  pubmed Ali M, Brady MC, Campbell P, Rooney S 等 2026 Aug 置信度 0.82
• Adaptive Variation Amid High Gene Flow Across a Broad Latitudinal Gradient in the Reef-Building Honeycomb Worm, Sabellaria alveolata.
  Climate change is already altering, and will continue to reshape, the persistence and spatial structure of marine populations. Understanding metapopulation connectivity and local adaptation is therefore critical for identifying both vulnerable populations and …
  pubmed Wilson EJ, Knights AM, Firth LB, Corporeau C 等 2026 Sep 置信度 0.82
• Eplontersen for Transthyretin Amyloid Cardiomyopathy.
  Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease caused by deposition of misfolded transthyretin (TTR). Eplontersen, an antisense oligonucleotide, reduces the production of hepatic TTR. The effect of eplonterse…
  pubmed Fontana M, Masri A, Solomon SD, Cappelli F 等 2026 Aug 28 置信度 0.82
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