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• Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains
  preprints 2025 置信度 0.74
• Kandinsky: enabling neighbourhood analysis of spatial omics data for functional insights on cell ecosystems
  preprints 2025 置信度 0.74
• Dimerization of the <i>S. cerevisiae</i> Spo11 core complex
  preprints 2026 置信度 0.74
• Genomic Analyses of Antibiotic-Resistant <i>Escherichia coli</i> From Extensive Beef Cattle and Sheep Farms Identifies Inter-Species and Farm-Farm Sharing as Clonal Dissemination Pathways
  preprints 2025 置信度 0.74
• Grounding Health AI: Architecture and Evaluation of a Domain-Expert Metabolic Health Agent
  General-purpose language models generate fluent health reports that can fabricate derived clinical met-rics. In an illustrative comparison on identical two-week CGM and meal data, leading foundation models produced reports with invented MAGE values, inflated m…
  preprints 2026 置信度 0.74
• WormTagDB: A Systematic Survey of Endogenously Tagged Proteins in C. elegans and Roadmap Towards the Tagged Proteome
  preprints 2025 置信度 0.74
• CoMR: an integrative scoring pipeline for Comprehensive Mitochondrial proteome Reconstruction across eukaryotes
  preprints 2026 置信度 0.74
• TEDLH: Domain HMMs for sensitive detection of remote homologues
  preprints 2026 置信度 0.74
• Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death
  preprints 2025 置信度 0.74
• Innovative PLM Methodology Framework for Bionics with Built-in Reverse Biomimetics for Innovative Product Development: From Inception to Proof-of-Concept and Clinical Validation of Large-Scale, Human Skeletal Systems
  preprints 2024 置信度 0.74
• Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
  Biomolecular condensates are membraneless compartments, crucial for organising and regulating diverse cellular processes. Current approaches to study condensate biology either use simplified recombinant protein systems with limited physiological relevance, or …
  preprints 2025 置信度 0.74
• Fast, flexible gene cluster family delineation with IGUA
  ABSTRACT Prokaryotic genomes harbor a variety of functional elements encoded as contiguous multi-gene clusters, with biosynthetic gene clusters (BGCs, genetic determinants of secondary metabolite biosynthesis) serving as a notable example. In a typical workflo…
  preprints 2025 置信度 0.74
• Genetic and Causal Associations Between Tobacco Smoking and Mental Health After Accounting for General Substance Use and Socioeconomic Factors
  preprints 2026 置信度 0.74
• Identification of brain-like complex information architectures in embryonic tissue of Xenopus laevis organoids
  preprints 2024 置信度 0.74
• Neural Ordinary Differential Equations Inspired Parameterization of Kinetic Models
  preprints 2024 置信度 0.74
• Distinct molecular profiles characterize the spontaneous growth rate of IDHmt low-grade astrocytoma and oligodendroglioma, WHO grade 2
  preprints 2025 置信度 0.74
• A Capsid Tyrosine Residue Governs the Proteolytic Inactivation of Echovirus 11 in Lakewater
  preprints 2026 置信度 0.74
• usiGrabber: Automating the curation of proteomics spectra data at scale, making large datasets ready for use in machine learning systems
  preprints 2026 置信度 0.74
• Stepwise and lineage-specific divergence of a major immune co-chaperone complex in leptosporangiate ferns
  preprints 2025 置信度 0.74
• Recapitulating whipworm development <i>in vitro</i> using caecaloids
  preprints 2026 置信度 0.74
• Hybrid Quorum Sensing and Machine Learning Systems for Adaptive Synthetic Biology: Toward Autonomous Gene Regulation and Precision Therapies
  preprints 2024 置信度 0.74
• Resource supplementation alters host exposure, susceptibility, and infection dynamics across a diverse parasite community
  preprints 2025 置信度 0.74
• Biotic-response networks are an important organizer of the transcriptome in wild <i>Arabidopsis thaliana</i> populations
  preprints 2026 置信度 0.74
• A natural history of AMR in <i>Klebsiella pneumoniae</i> : Global diversity, predictors, and predictions of evolutionary pathways
  preprints 2025 置信度 0.74
• A tRNA-gRNA multiplexing system for CRISPR genome editing in <i>Marchantia polymorpha</i>
  preprints 2025 置信度 0.74
• Functional Lipid Analysis via Index-Based Lipidomics Profile: A New Computational Module in LipidOne
  preprints 2025 置信度 0.74
• Comparison of multiple cefiderocol susceptibility testing methods against genomic determinants of resistance in <i>bla</i> _NDM carbapenemase producing Enterobacterales
  preprints 2026 置信度 0.74
• ssDNA phage FLiP resides in dsDNA form in resistant <i>Flavobacterium</i> host
  preprints 2025 置信度 0.74
• Escalating human exposure to tropical mosquito-borne viruses in Europe
  preprints 2025 置信度 0.74
• ‘Truthsets’ for clinical validation of large-scale functional assays: Practice recommendations from Cancer Variant Interpretation Group UK (CanVIG-UK)
  preprints 2026 置信度 0.74
• Tmn blocks phage spread via plasmolysis and triggers synergistic defence responses
  Membrane-associated phage defences remain poorly understood. Here we characterise Tmn, a YobI-family transmembrane P-loop NTPase that protects bacteria from phage infection by establishing a plasmolysis-associated antiviral state. Upon recognising phage T2 RII…
  preprints 2026 置信度 0.74
• Getting over ANOVA: Estimation graphics for multi-group comparisons
  Data analysis in experimental science mainly relies on null-hypothesis significance testing, despite its well-known limitations. A powerful alternative is estimation statistics, which focuses on effect-size quantification. However, current estimation tools str…
  preprints 2026 置信度 0.74
• Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition
  In this report, we summarize and analyze the 2024 Adaptyv protein design competition. Participants used computational and Machine Learning (ML) methods of their choice to design proteins that bind the Epidermal Growth Factor Receptor (EGFR), a key drug target …
  preprints 2025 置信度 0.74
• Designing spatial adaptive surveillance for the emerging malaria vector <i>Anopheles stephensi</i> in Eastern and Horn of Africa
  preprints 2026 置信度 0.74
• Damselflies Overcome Color Saturation Barriers of Photonic Glasses <i>via</i> Structural Dispersion and Pigment Loading
  preprints 2025 置信度 0.74
• <i>In-cell</i> structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells
  preprints 2025 置信度 0.74
• Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility
  preprints 2026 置信度 0.74
• Microgravity affects the nervous system and aging in <i>C. elegans</i> through reduced tactile stimulation
  preprints 2026 置信度 0.74
• Stable transformation of <i>Micractinium conductrix</i> SAG 241.80: New tools for exploring photosymbiotic interactions
  preprints 2026 置信度 0.74
• Inferential planning in the frontal cortex
  How the brain plans and maintains sequences of future actions remains a central question in systems neuroscience. Recent studies in the frontal cortex have revealed that multiple elements of a sequence are represented simultaneously in separable neural subspac…
  preprints 2025 置信度 0.74
• Towards foundation models that learn across biological scales
  We have reached a point where many bio foundation models exist across 4 different scales, from molecules to molecular chains, cells, and tissues. However, while related in many ways, these models do not yet bridge these scales. We present a framework and archi…
  preprints 2025 置信度 0.74
• Integrative analysis of angiogenic signaling in obesity: capillary features and VEGF binding kinetics
  preprints 2024 置信度 0.74
• Coinfections dampen the effects of temperature on host-parasite interactions
  preprints 2025 置信度 0.74
• Fasting reverses PLN R14del-mediated cardiomyopathy through lysosomal reactivation
  preprints 2026 置信度 0.74
• Self-Organizing Systems: What, How, and Why?
  preprints 2024 置信度 0.74
• Gene flow between environmental and enteric bacteria with environmental coselection for metal and antibiotic resistance genes: A case study
  preprints 2025 置信度 0.74
• Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank
  preprints 2026 置信度 0.74
• Carbon burial outweighs the climate impact of methane emissions across global aquatic ecosystems
  preprints 2026 置信度 0.74
• Redox-constrained microbial ecology dictates nitrogen loss versus retention
  preprints 2025 置信度 0.74
• Enhanced RNA Formation Under Amine-Rich Local Atmospheres from 2’,3’-Cyclic Nucleotides
  preprints 2026 置信度 0.74
• Making Neurobots and Chimerical Ctenophores
  preprints 2024 置信度 0.74
• Intracellular compartmentalization shapes lipid access and metabolic fitness of mycobacteria
  Intracellular mycobacteria encounter distinct metabolic environments as they transition between vacuolar and cytosolic compartments within host cells, yet how nutrient access is shaped by this compartmentalization remains poorly understood. Here, we use Mycoba…
  preprints 2026 置信度 0.74
• An evolutionary systems approach to language and music: measuring predictive dynamics with viewpoint graph networks
  preprints 2025 置信度 0.74
• Evolutionary Biology, Social Entrepreneurship, and Innovationology: Cultivating Resilient, Adaptive Solutions
  preprints 2024 置信度 0.74
• Strong promoters are mutationally robust
  preprints 2025 置信度 0.74
• Reduced Pupil-Linked Arousal Marks Implicit Memory for Complex Auditory Sequences
  preprints 2026 置信度 0.74
• Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions
  preprints 2025 置信度 0.74
• Native Mass Spectrometry Analysis of Cullin RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation
  preprints 2025 置信度 0.74
• Five years of national airborne pollen monitoring in South Africa: Biome-specific calendars to inform allergy diagnosis and prevention
  preprints 2025 置信度 0.74
• Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis
  Brain-age prediction from neuroimaging data provides a proxy of biological aging, yet most models rely on structural magnetic resonance imaging (MRI), a modality that captures macroanatomy but offers limited biological specificity. We tested whether integratin…
  preprints 2025 置信度 0.74
• Modular pathway engineering for enhancing terpenoid production in plants.
  europepmc 2026 置信度 0.80
• Effects of black soldier fly (Hermetia illucens L.) larvae zoocompost on the mineral element content of blue honeysuckle berries.
  europepmc 2026 置信度 0.80
• Genomic evidence of ecological flexibility and cross-niche CRISPR spacerome targeting phage-plasmid hybrids in Latilactobacillus curvatus.
  europepmc 2026 置信度 0.80
• Plant microbiome engineering: from inoculation to genome editing.
  Plant-associated microbiomes are central to crop productivity, nutrient efficiency, and stress resilience, yet conventional microbiome manipulation strategies, largely based on microbial inoculation and agronomic management, often suffer from inconsistent fiel…
  europepmc 2026 置信度 0.80
• Foundational issues of network models in biology.
  europepmc 2026 置信度 0.80
• Bacteriophage therapy against multidrug resistant bacterial infections demonstrates clinical advances and engineering innovations between 2020-2026.
  europepmc 2026 置信度 0.80
• Systemic Molecular Network Alterations Associated with FoxA2 in Gastric Cancer.
  europepmc 2026 置信度 0.80
• The evolving landscape of molecular visualization.
  europepmc 2026 置信度 0.80
• Electrical Stimulation-Induced Modulation of Small Extracellular Vesicles in Regenerative Therapy.
  europepmc 2026 置信度 0.80
• Sovereign AI supercomputers: a global landscape review of unprecedented biomedical research infrastructure.
  Artificial intelligence (AI) has rapidly become the focal point of global governmental attention and investment. Nations are launching AI for science strategies on a scale comparable to historic endeavors such as Apollo and the Manhattan Project. These coordin…
  europepmc 2026 置信度 0.80
• Multi-applications and Aquaculture of Seaweeds: Environmental Improvement, Health Benefit, and Sustainable Valorization with Integrated Artificial Intelligence.
  Environmental and human health applications of seaweeds (SWs) have received attention in recent years. However, previous reviews lack of covering SWs from cultivation to their various applications, along with the integration of artificial intelligence (AI). Th…
  europepmc 2026 置信度 0.80
• Rationales for the Choice of Metals for Super-Reduced Biological Metal Centers: Cobalt in Cobalamin Versus Nickel in F&lt;sub&gt;430&lt;/sub&gt;.
  europepmc 2026 置信度 0.80
• Bacterial conjugation and its deployment for diverse biotechnology applications.
  Conjugation has emerged as an attractive tool in synthetic biology by delivering designed genetic circuits to diverse microbes simultaneously without isolation. Insights into conjugative machinery have enabled the repurposing of these systems to deliver geneti…
  europepmc 2026 置信度 0.80
• Systems-Level Insights Into Microbial Naphthalene Biodegradation: An Integrated In Silico and Omics Perspective.
  europepmc 2026 置信度 0.80
• Engineered Bacteria as Living Materials for Oral Delivery of Peptide Drugs.
  europepmc 2026 置信度 0.80
• Lung organoids for respiratory diseases: overcoming translational hurdles in drug discovery and safety assessment.
  europepmc 2026 置信度 0.80
• A Swivel Microwell platform for rotational assembly and co-culture of multiple spheroids.
  europepmc 2026 置信度 0.80
• Two years at the editor's desk: reflections on community, diversity and impact.
  europepmc 2026 置信度 0.80
• Advances in anthocyanins: Chemical foundations, synthetic biology, molecular mechanisms, physicochemical properties, and applications in the food industry.
  europepmc 2026 置信度 0.80
• Unveiling toxicological adverse outcomes: toward construction and simulation of large-scale networks.
  europepmc 2026 置信度 0.80
• Editorial: Insights in biosafety and biosecurity 2024/2025: novel developments, current challenges, and future perspectives.
  europepmc 2026 置信度 0.80
• Wine chemistry and language bottleneck hypothesis: insights from large language models.
  europepmc 2026 置信度 0.80
• Nonlinear Redox-Immune Coupling Under Low-Dose-Rate Radiation: A Compartment-Specific Framework for Biological Responses-A Narrative Review.
  europepmc 2026 置信度 0.80
• Development of Nanosystems Delivering with Eco-Friendly Antibacterial Agents Composed of &lt;i&gt;Zingiber officinale/Alpinia galanga&lt;/i&gt; and Gold, as Sustainable Antibiotics.
  europepmc 2026 置信度 0.80
• Protein-directed nucleotide selection in the DRT3 defense system: mechanism, biological context, and constraints on programmability.
  europepmc 2026 置信度 0.80
• The SVP-FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis.
  europepmc 2026 置信度 0.80
• Metabolic engineering of microorganisms for the production of fatty acid-derived biofuels.
  europepmc 2026 置信度 0.80
• Dose-dependent effects of zinc oxide nanoparticles on pre-osteoblast cellular response.
  europepmc 2026 置信度 0.80
• Faunistic updates on Greek ants: First record of &lt;i&gt;Strumigenys membranifera&lt;/i&gt; (Emery, 1869) from Crete and &lt;i&gt;Strumigenys baudueri&lt;/i&gt; (Emery, 1875) from Andros.
  europepmc 2026 置信度 0.80
• Engineered Probiotics Protect against &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Post Antibiotic Exposure.
  europepmc 2026 置信度 0.80
• Engineering glowing plants: recent progress and future directions for application-oriented design.
  europepmc 2026 置信度 0.80
• Next-generation fermented foods: engineering the future of functional nutrition and emerging food safety challenges.
  Fermented foods have long been recognized for their significant contributions to human health, particularly in enhancing gastrointestinal functionality, increasing microbial diversity, and improving nutrient bioavailability. In recent years, the intersection o…
  europepmc 2026 置信度 0.80
• Polymer-stabilized amorphous CuO-ZnO hybrid nanocomplex as a promising candidate for antimicrobial therapy and controlled drug delivery with molecular docking insights.
  europepmc 2026 置信度 0.80
• microntology: a lightweight, data-driven controlled vocabulary to describe earth's microbial habitats.
  europepmc 2026 置信度 0.80
• Five-layer systems analysis of &lt;i&gt;Leishmania&lt;/i&gt; stage differentiation reveals an essential role for protein degradation in parasite development.
  europepmc 2026 置信度 0.80
• The insects as food and feed industry needs integrative solutions.
  The edible insect industry is inherently multidisciplinary. The increasing interest in edible insect production for food and feed has driven an increasing number of research outputs covering biology, engineering, economics, and more. However, research spanning…
  europepmc 2026 置信度 0.80
• Improving meat quality of the broiler chicken: integrated mechanistic frameworks linking pre-slaughter determinants, postmortem transformations, and multi-omics technology.
  europepmc 2026 置信度 0.80
• Probiotic-Plant Bioactive Synergy in Gut Health: Mechanisms, Antimicrobial Activity, and Translational Challenges.
  europepmc 2026 置信度 0.80
• Tunable Transcription-Level CRISPR Interference in &lt;i&gt;Vibrio natriegens&lt;/i&gt; Using Engineered Single Guide RNAs.
  europepmc 2026 置信度 0.80
• NSFC-funded Chinese materia medica research (2015-2024): achievements output, research characteristics, and evolution.
  europepmc 2026 置信度 0.80