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• Tricho-Hepato-Enteric Syndromic Immunodeficiency: Clinical Spectrum, Pathobiology, and Emerging Therapies.
  pubmed Mandola AB, Frizinsky S, Somekh I, Naor S 等 2026 Aug 置信度 0.82
• Extended-Spectrum Beta-Lactamase (ESBL)-Producing E. coli in Livestock and Free-Roaming Wildlife: A Combined Phenotyping-Whole-Genome Sequencing One Health Approach.
  pubmed Conforti S, Kapopoulou A, Bank C, Köchle B 等 2026 置信度 0.82
• Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).
  pubmed Xiong J, Shang M, Bao J, Liu T 等 2026 Aug 6 置信度 0.82
• A comparative mutation-selection reanalysis of colon and rectal adenocarcinoma highlights PIK3CA variants and BRAF V600E.
  pubmed Ke L, Cecchini M, Townsend JP 2026 Aug 5 置信度 0.82
• Retraction Note: Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma.
  pubmed Zhang Y, Zhang T, Yin Q, Luo H 2026 Aug 5 置信度 0.82
• Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.
  pubmed Ran C, Deborgies Sanches C, Swedblom J, Wellfelt K 等 2026 Aug 4 置信度 0.82
• Protective or Therapeutic Effect of Exosomes Isolated From Mesenchymal Stem Cells on Cisplatin-Induced Ovarian Damage.
  pubmed Yay A, Gonen ZB, Kalkan KT, Yalcın B 等 2026 Aug 5 置信度 0.82
• Neanderthal gene makes some modern humans taller and more muscular.
  pubmed Basu M 2026 Aug 5 置信度 0.82
• Maps of chromosomal regions crucial for cell division reveal high diversity.
  pubmed 2026 Aug 5 置信度 0.82
• Discovery and mapping of a new gene in wheat for race-specific adult plant resistance to Puccinia striiformis f. sp. tritici.
  pubmed Park RF, Chhetri M, Sandhu KS, Ziems L 等 2026 Aug 5 置信度 0.82
• Integrating clinically actionable biomarkers into bladder cancer care - recommendations from the International Bladder Cancer Group.
  pubmed Hensley PJ, Teoh JYC, Li R, Gupta S 等 2026 Aug 5 置信度 0.82
• The role of genetic variation in apolipoprotein response to diet among Brazilians with cardiovascular disease.
  pubmed Bersch-Ferreira AC, Santos RHN, Rogero MM, Machado RHV 等 2026 Aug 5 置信度 0.82
• Clinical and genomic determinants of extraordinary response and resistance to androgen receptor pathway inhibitors in men with metastatic androgen pathway modulator sensitive (APMS) prostate cancer.
  pubmed McKenzie J, Howard L, Park JJ, Ashraf B 等 2026 Aug 5 置信度 0.82
• Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice.
  pubmed Kim JS, Uppalapati S, Margolis A, McClelland M 等 2026 Aug 5 置信度 0.82
• Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia.
  pubmed Letebo A, Vanheer LN, Engdaw M, Ejigu LA 等 2026 Aug 5 置信度 0.82
• Detecting pathogenic structural variation in families with undiagnosed rare disease in a national genome project.
  pubmed Dutta P, Pagnamenta AT, Robert C, McGuigan AEF 等 2026 Aug 5 置信度 0.82
• Patients' and parents' views on how digital tools enable personalized and partnered care in genetics: a qualitative study.
  pubmed Assamad D, Saeedi S, Grewal S, Jha V 等 2026 Aug 5 置信度 0.82
• Uncovering the mechanism of female restitution in sugarcane hybrids.
  pubmed Zhu S, Tang H, Jones T, Fumia N 等 2026 Aug 5 置信度 0.82
• Stimulation modulates gene-linked cell assemblies in the human brain.
  pubmed Moore H, Dehnad M, Freelin A, Granger B 等 2026 Aug 5 置信度 0.82
• Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations.
  pubmed Poh AR, Sexton A, Pietrzak H, De Losa R 等 2026 Aug 3 置信度 0.82
• Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis.
  pubmed Vasileva DP, Chhetri HB, Hochanadel LH, Streich JC 等 2026 Aug 5 置信度 0.82
• The Novel HLA-A Allele, HLA-A*26:269Q, Was Identified in a Bone Marrow Donor.
  pubmed Loginova M, Morozova N, Paramonov I 2026 Aug 置信度 0.82
• Parent-child connectedness and its associations with sexual risk behavior and outcomes among young people: a systematic review and meta-analysis.
  pubmed RenChen X, Wu B, Dang Z 2026 Aug 17 置信度 0.82
• Emerging imipenem resistance in Nocardia infections in Taiwan: a retrospective cohort study at a tertiary teaching hospital.
  pubmed Jhou DW, Yang CY, Lao CK, Chen NY 等 2026 Aug 4 置信度 0.82
• Air pollution and rheumatoid arthritis disease activity: linking pathogenesis and progression.
  pubmed Sparks JA 2026 Aug 5 置信度 0.82
• Antibacterial and antibiofilm activities of Zn(2+) against Staphylococcus aureus and Streptococcus mutans.
  pubmed Shu F, Wang Z, Chen W, Liu M 2026 Aug 5 置信度 0.82
• Medication Use in Pregnancy/Lactation and Neonates: Threading the Needle.
  pubmed Davis JM, Norwitz ER 2026 Sep 置信度 0.82
• Omission of Axillary Surgery for Low-Risk Breast Cancer.
  pubmed Pawloski KR, Barrio AV 2026 Sep 置信度 0.82
• OrthoFinder: phylogenetic orthology inference for comparative genomics
  Here, we present a major advance of the OrthoFinder method. This extends OrthoFinder's high accuracy orthogroup inference to provide phylogenetic inference of orthologs, rooted gene trees, gene duplication events, the rooted species tree, and comparative genom…
  openalex David Emms, Steven Kelly 2019-11-14 置信度 0.72 InferencePhylogenetic treeBiologyGenomicsComputational biology
• Integrated genomic analyses of ovarian carcinoma
  A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylatio…
  openalex Debra Bell, Andrew Berchuck, Michael J. Birrer, Marcin Imieliński 等 2011-06-28 置信度 0.72 Ovarian cancerBiologymicroRNADNA methylationExon
• Efficient Methods to Compute Genomic Predictions
  Efficient methods for processing genomic data were developed to increase reliability of estimated breeding values and to estimate thousands of marker effects simultaneously. Algorithms were derived and computer programs tested with simulated data for 2,967 bul…
  openalex P.M. VanRaden 2008-10-22 置信度 0.72 Linkage disequilibriumGenomic selectionStatisticsLinkage (software)Selection (genetic algorithm)
• The UK Biobank resource with deep phenotyping and genomic data
  The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size and scope. …
  openalex Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band 等 2018-10-02 置信度 0.72 BiobankImputation (statistics)GenotypeBiologyPopulation
• Integrated genomic characterization of endometrial carcinoma
  We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterat…
  openalex Douglas A. Levine 2013-04-30 置信度 0.72 PTENCancer researchSerous fluidBiologyEndometrial cancer
• The Somatic Genomic Landscape of Glioblastoma
  openalex Cameron Brennan, Roel G.W. Verhaak, Aaron McKenna, Benito Campos 等 2013-10-01 置信度 0.72 BiologySomatic cellGlioblastomaGeneticsComputational biology
• Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
  openalex Roujian Lu, Xiang Zhao, Juan Li, Peihua Niu 等 2020-01-30 置信度 0.72 Phylogenetic treeBiologyCoronavirusVirologySanger sequencing
• Phytozome: a comparative platform for green plant genomics
  The number of sequenced plant genomes and associated genomic resources is growing rapidly with the advent of both an increased focus on plant genomics from funding agencies, and the application of inexpensive next generation sequencing. To interact with this i…
  openalex David Goodstein, Shengqiang Shu, Russell W. Howson, Rochak Neupane 等 2011-11-22 置信度 0.72 BiologyGenomeGenomicsComparative genomicsFunctional genomics
• Shifting the genomic gold standard for the prokaryotic species definition
  DNA-DNA hybridization (DDH) has been used for nearly 50 years as the gold standard for prokaryotic species circumscriptions at the genomic level. It has been the only taxonomic method that offered a numerical and relatively stable species boundary, and its use…
  openalex Michael Richter, Ramon Rosselló‐Móra 2009-10-23 置信度 0.72 Pairwise comparisonGenomeComputational biologyGenomicsBiology
• tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence
  We describe a program, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases. Two previously described tRNA detection programs are used as fast, first-pass prefilters to identify …
  openalex Todd M. Lowe, Sean R. Eddy 1997-03-01 置信度 0.72 Transfer RNABiologyGeneticsGeneRNA
• Software for Computing and Annotating Genomic Ranges
  We describe Bioconductor infrastructure for representing and computing on annotated genomic ranges and integrating genomic data with the statistical computing features of R and its extensions. At the core of the infrastructure are three packages: IRanges, Geno…
  openalex Michael Lawrence, Wolfgang Huber, Hervé Pagès, Patrick Aboyoun 等 2013-08-08 置信度 0.72 BioconductorComputer scienceScalabilitySoftwareVisualization
• miRBase: tools for microRNA genomics
  miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over …
  openalex Sam Griffiths‐Jones, Harpreet K. Saini, Stijn van Dongen, Anton J. Enright 2007-11-08 置信度 0.72 MiRBaseBiologymicroRNAComputational biologyGenomics
• An Integrated Genomic Analysis of Human Glioblastoma Multiforme
  Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide …
  openalex D. Williams Parsons, Siân Jones, Xiaosong Zhang, Jimmy Lin 等 2008-09-04 置信度 0.72 IDH1Isocitrate dehydrogenaseGlioblastomaGeneBiology
• Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
  Two new methods were used to establish a rapid and highly sensitive prenatal diagnostic test for sickle cell anemia. The first involves the primer-mediated enzymatic amplification of specific beta-globin target sequences in genomic DNA, resulting in the expone…
  openalex Randall K. Saiki, Stephen J. Scharf, Fred Faloona, Kary B. Mullis 等 1985-12-20 置信度 0.72 Restriction enzymeMolecular biologygenomic DNAEndonucleaseBiology
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways
  Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensi…
  openalex Roger E. McLendon, D D Bigner, Allan H. Friedman, Erwin G. Van Meir 等 2008-09-04 置信度 0.72 DNA methylationBiologyGeneEpigeneticsCancer
• From genomics to chemical genomics: new developments in KEGG
  The increasing amount of genomic and molecular information is the basis for understanding higher-order biological systems, such as the cell and the organism, and their interactions with the environment, as well as for medical, industrial and other practical ap…
  openalex Minoru Kanehisa 2005-12-28 置信度 0.72 KEGGChemical spaceGenomicsBiologyFunctional genomics
• Mauve: Multiple Alignment of Conserved Genomic Sequence With Rearrangements
  As genomes evolve, they undergo large-scale evolutionary processes that present a challenge to sequence comparison not posed by short sequences. Recombination causes frequent genome rearrangements, horizontal transfer introduces new sequences into bacterial ch…
  openalex Aaron E. Darling, Bob Mau, Frederick R. Blattner, Nicole T. Perna 2004-07-01 置信度 0.72 GenomeBiologyComputational biologyLineage (genetic)Genetics
• Genomic Classification and Prognosis in Acute Myeloid Leukemia
  BACKGROUND: Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice. METHODS: We e…
  openalex Elli Papaemmanuil, Moritz Gerstung, Lars Bullinger, Verena I. Gaidzik 等 2016-06-08 置信度 0.72 NPM1Myeloid leukemiaMedicineMutationGenetics
• Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
  openalex Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom, Victoria Wang 等 2010-01-01 置信度 0.72 PDGFRABiologyIDH1TranscriptomeGene
• Stacks: an analysis tool set for population genomics
  Massively parallel short-read sequencing technologies, coupled with powerful software platforms, are enabling investigators to analyse tens of thousands of genetic markers. This wealth of data is rapidly expanding and allowing biological questions to be addres…
  openalex Julian Catchen, Paul A. Hohenlohe, Susan Bassham, Angel Amores 等 2013-05-24 置信度 0.72 Population genomicsGenomicsBiologyMassively parallelSoftware
• Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
  We explored genomic expression patterns in the yeast Saccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels over time for almost every yeast gene, as cells responded to temper…
  openalex Audrey P. Gasch, Paul T. Spellman, Camilla M. Kao, Orna Carmel‐Harel 等 2000-12-01 置信度 0.72 BiologySaccharomyces cerevisiaeYeastGeneGenetics
• Visualizing and interpreting cancer genomics data via the Xena platform
  openalex Mary J. Goldman, Brian Craft, Mim Hastie, Kristupas Repečka 等 2020-05-22 置信度 0.72 GenomicsComputational biologyBiologyData scienceGenome
• Genomic Classification of Cutaneous Melanoma
  We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes bas…
  openalex Rehan Akbani, Kadir C. Akdemir, Bülent Arman Aksoy, Monique Albert 等 2015-06-01 置信度 0.72 BiologyMelanomaMutantCancer researchGene
• Orchestrating high-throughput genomic analysis with Bioconductor
  openalex Wolfgang Huber, Vincent J. Carey, Robert Gentleman, Simon Anders 等 2015-01-29 置信度 0.72 BioconductorInteroperabilityComputer scienceSoftwareData science
• Comprehensive genomic characterization of squamous cell lung cancers
  Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been s…
  openalex Peter S. Hammerman, Michael S. Lawrence, Douglas Voet, Rui Jing 等 2012-09-07 置信度 0.72 CDKN2ACancer researchBiologyLung cancerPTEN
• Prediction of complete gene structures in human genomic DNA
  openalex Chris Burge, Samuel Karlin 1997-04-01 置信度 0.72 ExonIntronGeneGeneticsBiology
• Genomic Control for Association Studies
  A dense set of single nucleotide polymorphisms (SNP) covering the genome and an efficient method to assess SNP genotypes are expected to be available in the near future. An outstanding question is how to use these technologies efficiently to identify genes aff…
  openalex Bernie Devlin, Kathryn Roeder 1999-12-01 置信度 0.72 Bonferroni correctionOutlierFalse positive paradoxSingle-nucleotide polymorphismSNP
• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
  openalex METABRIC Group, Christina Curtis, Sohrab P. Shah, Suet‐Feung Chin 等 2012-04-17 置信度 0.72 BiologyTranscriptomeBreast cancerGeneCopy-number variation
• Integrative Genomic Profiling of Human Prostate Cancer
  openalex Barry S. Taylor, Nikolaus Schultz, Haley Hieronymus, Anuradha Gopalan 等 2010-06-25 置信度 0.72 Prostate cancerChromoplexyBiologyTMPRSS2Prostate
• A Genomic Perspective on Protein Families
  In order to extract the maximum amount of information from the rapidly accumulating genome sequences, all conserved genes need to be classified according to their homologous relationships. Comparison of proteins encoded in seven complete genomes from five majo…
  openalex Roman L. Tatusov, Eugene V. Koonin, David J. Lipman 1997-10-24 置信度 0.72 GenomeBiologyPhylogenetic treeGeneticsComputational biology
• VISTA: computational tools for comparative genomics
  Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here, we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-…
  openalex Kelly A. Frazer, Lior Pachter, Alexandre Poliakov, Edward M. Rubin 等 2004-07-01 置信度 0.72 BiologyGenomeComparative genomicsGenomicsComputational biology
• Genomic analyses identify molecular subtypes of pancreatic cancer
  openalex Peter J. Bailey, David K. Chang, Kátia Nones, Amber L. Johns 等 2016-02-23 置信度 0.72 BiologyPDX1Pancreatic cancerCancer researchKRAS
• Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
  openalex Steffen Durinck, Paul T. Spellman, Ewan Birney, Wolfgang Huber 2009-07-22 置信度 0.72 EnsemblBioconductorComputer scienceIdentifierComputational biology
• Integrative Clinical Genomics of Advanced Prostate Cancer
  openalex Dan R. Robinson, Eliezer M. Van Allen, Yi-Mi Wu, Nikolaus Schultz 等 2015-05-01 置信度 0.72 Prostate cancerBiologyPTENExome sequencingCancer
• lincRNAs: Genomics, Evolution, and Mechanisms
  openalex Igor Ulitsky, David P. Bartel 2013-07-01 置信度 0.72 BiologyGenomicsGenomeComputational biologyVertebrate
• Using RepeatMasker to Identify Repetitive Elements in Genomic Sequences
  RepeatMasker is a popular software tool widely used in computational genomics to identify, classify, and mask repetitive elements, including low-complexity sequences and interspersed repeats. RepeatMasker searches for repetitive sequence by aligning the input …
  openalex Maja Tarailo‐Graovac, Nansheng Chen 2009-03-01 置信度 0.72 UnixComputer scienceSequence (biology)SoftwareSequence alignment
• Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia
  BACKGROUND: Fluorescence in situ hybridization has improved the detection of genomic aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal abnormalities in patients with chronic lymphocytic leukemia and assessed their prognos…
  openalex Hartmut Döhner, Stephan Stilgenbauer, Axel Benner, Elke Leupolt 等 2000-12-28 置信度 0.72 Chronic lymphocytic leukemiaTrisomyFluorescence in situ hybridizationComparative genomic hybridizationCytogenetics
• Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
  BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS: We analyzed the genomes of 200 clinically annota…
  openalex The Cancer Genome Atlas Research Network 2013-05-02 置信度 0.72 EpigenomicsMedicineMyeloid leukemiaMyeloidLeukemia
• Comprehensive genomic characterization of head and neck squamous cell carcinomas
  The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the…
  openalex The Cancer Genome Atlas Network 2015-01-27 置信度 0.72 HRASCDKN2ACancer researchBiologyHead and neck squamous-cell carcinoma
• Integrated Genomic Characterization of Papillary Thyroid Carcinoma
  Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterat…
  openalex Nishant Agrawal, Rehan Akbani, Bülent Arman Aksoy, Adrian Ally 等 2014-10-01 置信度 0.72 BiologyThyroid carcinomaCancer researchThyroid cancerGene
• Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
  Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource…
  openalex Wanjuan Yang, Jorge Soares, Patricia Greninger, Elena J. Edelman 等 2012-11-22 置信度 0.72 BiologyDrug discoveryGenomicsComputational biologyCancer
• The Genomic Landscapes of Human Breast and Colorectal Cancers
  Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes i…
  openalex Laura D. Wood, D. Williams Parsons, Siân Jones, Jimmy Lin 等 2007-10-11 置信度 0.72 CarcinogenesisGeneBiologyExonGenomics
• RepeatModeler2 for automated genomic discovery of transposable element families
  The accelerating pace of genome sequencing throughout the tree of life is driving the need for improved unsupervised annotation of genome components such as transposable elements (TEs). Because the types and sequences of TEs are highly variable across species,…
  openalex Jullien M. Flynn, Robert Hubley, Clément Goubert, Jeb Rosen 等 2020-04-16 置信度 0.72 AnnotationGenomeTransposable elementComputational biologyBiology
• Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
  DNA microarrays containing virtually every gene of Saccharomyces cerevisiae were used to carry out a comprehensive investigation of the temporal program of gene expression accompanying the metabolic shift from fermentation to respiration. The expression profil…
  openalex Joseph L. DeRisi, Vishwanath R. Iyer, Patrick O. Brown 1997-10-24 置信度 0.72 DNA microarrayYAP1BiologyGeneGene expression
• Genomic instability — an evolving hallmark of cancer
  openalex Simona Negrini, Vassilis G. Gorgoulis, Thanos D. Halazonetis 2010-02-23 置信度 0.72 Genome instabilityBiologyCDKN2AGeneticsDNA repair
• REPuter: the manifold applications of repeat analysis on a genomic scale
  The repetitive structure of genomic DNA holds many secrets to be discovered. A systematic study of repetitive DNA on a genomic or inter-genomic scale requires extensive algorithmic support. The REPuter program described herein was designed to serve as a fundam…
  openalex Stefan Kurtz 2001-11-15 置信度 0.72 BiologyComputational biologyScope (computer science)genomic DNARepeated sequence
• Metagenomics: Application of Genomics to Uncultured Microorganisms
  Metagenomics (also referred to as environmental and community genomics) is the genomic analysis of microorganisms by direct extraction and cloning of DNA from an assemblage of microorganisms. The development of metagenomics stemmed from the ineluctable evidenc…
  openalex Jo Handelsman 2004-12-01 置信度 0.72 MetagenomicsBiologyEnvironmental DNAGenomeHorizontal gene transfer
• The DisGeNET knowledge platform for disease genomics: 2019 update
  One of the most pressing challenges in genomic medicine is to understand the role played by genetic variation in health and disease. Thanks to the exploration of genomic variants at large scale, hundreds of thousands of disease-associated loci have been uncove…
  openalex Janet Piñero, Juan Manuel Ramírez‐Anguita, Josep Saüch-Pitarch, Francesco Ronzano 等 2019-10-18 置信度 0.72 GenomicsInteroperabilityBiologySuiteStandardization
• Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors
  Comparative genomic hybridization produces a map of DNA sequence copy number as a function of chromosomal location throughout the entire genome. Differentially labeled test DNA and normal reference DNA are hybridized simultaneously to normal chromosome spreads…
  openalex Anne Kallioniemi, Olli Kallioniemi, Damir Sudar, Denis Rutovitz 等 1992-10-30 置信度 0.72 Comparative genomic hybridizationBiologyChromosomeMolecular biologyDNA
• Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
  openalex Alexis C. Komor, Y. Bill Kim, Michael S. Packer, John A. Zuris 等 2016-04-19 置信度 0.72 Genome editingIndelCRISPRCytidine deaminaseCas9
• Python Materials Genomics (pymatgen): A robust, open-source python library for materials analysis
  openalex Shyue Ping Ong, William D. Richards, Anubhav Jain, Geoffroy Hautier 等 2012-12-08 置信度 0.72 Python (programming language)Computer scienceComputational scienceSoftwareApplication programming interface
• Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
  openalex Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer 等 2017-10-24 置信度 0.72 DeaminationPoint mutationDNACRISPRCytosine
• Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
  A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs). Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently deleted and/or down-regulated in patients with B cell chronic lymphocytic leukemia, a disor…
  openalex George A. Calin, Cinzia Sevignani, Calin Dan Dumitru, Terry Hyslop 等 2004-02-18 置信度 0.72 Chromosomal fragile siteBiologymicroRNABreakpointGene
• Genomic Analysis of Reactive Astrogliosis
  Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in response to all CNS injuries and diseases. To better understand the reactive astrocyte state, we used Affymetrix GeneChip arrays to profile gene expression in populations of …
  openalex Jennifer Zamanian, Lijun Xu, Lynette C. Foo, Navid Nouri 等 2012-05-02 置信度 0.72 AstrogliosisAstrocyteGliosisTranscriptomeBiology
• Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
  BACKGROUND: Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class.…
  openalex The Cancer Genome Atlas Research Network 2015-06-11 置信度 0.72 ATRXGliomaMedicineDNA methylationExome
• Mapping genomic loci implicates genes and synaptic biology in schizophrenia
  openalex Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi, Georgia Panagiotaropoulou 等 2022-04-08 置信度 0.72 BiologySchizophrenia (object-oriented programming)GeneComputational biologyGenetics
• Genomic imprinting: parental influence on the genome
  openalex Wolf Reik, Jörn Walter 2001-01-01 置信度 0.72 Genomic imprintingImprinting (psychology)EpigeneticsBiologyGenetics
• Machine learning applications in genetics and genomics
  openalex Maxwell W. Libbrecht, William Stafford Noble 2015-05-07 置信度 0.72 Machine learningArtificial intelligenceComputer scienceGenomicsUnsupervised learning
• Genomics, gene expression and DNA arrays
  openalex David J. Lockhart, Elizabeth A. Winzeler 2000-06-01 置信度 0.72 GenomicsFunctional genomicsComputational biologyDNAGene
• Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications
  The PubMLST.org website hosts a collection of open-access, curated databases that integrate population sequence data with provenance and phenotype information for over 100 different microbial species and genera. Although the PubMLST website was conceived as pa…
  openalex Keith A. Jolley, James E. Bray, Martin Maiden 2018-09-24 置信度 0.72 Multilocus sequence typingGenomicsGenomePopulationBiology
• Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
  openalex Willy Hugo, Jesse M. Zaretsky, Lu Sun, Chunying Song 等 2016-03-01 置信度 0.72 BiologyMelanomaCancer researchTranscriptomeMAPK/ERK pathway
• Metabolite profiling for plant functional genomics
  openalex Oliver Fiehn, Joachim Kopka, Peter Dörmann, Thomas Altmann 等 2000-11-01 置信度 0.72 EcotypeMetabolomicsMetabolite profilingFunctional genomicsArabidopsis
• Comprehensive genomic profiles of small cell lung cancer
  openalex Julie George, Jing Lim, Se Jin Jang, Yupeng Cun 等 2015-07-10 置信度 0.72 BiologyCancer researchSomatic cellGeneChromothripsis
• A vision for the future of genomics research
  openalex Francis S. Collins, Eric D. Green, Alan E. Guttmacher, Mark S. Guyer 2003-04-14 置信度 0.72 BlueprintGenomicsComputational biologyData scienceBiology
• Genomics is failing on diversity
  openalex Alice B. Popejoy, Stephanie M. Fullerton 2016-10-10 置信度 0.72 Diversity (politics)Precision medicineGenomicsComputational biologyBiology
• Heritability in the genomics era — concepts and misconceptions
  openalex Peter M. Visscher, William G. Hill, Naomi R. Wray 2008-03-04 置信度 0.72 HeritabilityBiologyMissing heritability problemGenomicsPopulation
• Role for DNA methylation in genomic imprinting
  openalex En Li, Caroline Beard, Rudolf Jaenisch 1993-12-01 置信度 0.72 Genomic imprintingDNA methylationBiologyImprinting (psychology)Genetics
• Genomic atlas of the human plasma proteome
  openalex Benjamin B. Sun, Joseph Maranville, James E. Peters, David Stacey 等 2018-05-29 置信度 0.72 Mendelian randomizationProteomeBiologyExpression quantitative trait lociComputational biology
• Genomic responses in mouse models poorly mimic human inflammatory diseases
  A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic stu…
  openalex Junhee Seok, H. Shaw Warren, Alex G. Cuenca, Michael Mindrinos 等 2013-02-11 置信度 0.72 Computational biologyHuman studiesTranslational medicineTranslational researchAnimal model
• Blast2GO: A Comprehensive Suite for Functional Analysis in Plant Genomics
  Functional annotation of novel sequence data is a primary requirement for the utilization of functional genomics approaches in plant research. In this paper, we describe the Blast2GO suite as a comprehensive bioinformatics tool for functional annotation of seq…
  openalex Ana Conesa, Stefan Götz 2008-04-30 置信度 0.72 AnnotationComputer scienceSuiteFunctional genomicsGenomics
• Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
  There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we performed a comprehensive genetic analysis of 24 pancreatic cancers. We firs…
  openalex Siân Jones, Xiaosong Zhang, D. Williams Parsons, Jimmy Lin 等 2008-09-04 置信度 0.72 BiologyCarcinogenesisPancreatic cancerTranscriptomeGene
• Inferring Correlation Networks from Genomic Survey Data
  High-throughput sequencing based techniques, such as 16S rRNA gene profiling, have the potential to elucidate the complex inner workings of natural microbial communities - be they from the world's oceans or the human gut. A key step in exploring such data is t…
  openalex Jonathan Friedman, Eric J. Alm 2012-09-20 置信度 0.72 Spurious relationshipCompositional dataHuman Microbiome ProjectMicrobiomeProfiling (computer programming)