生命科学 · 全部实体（第 89 / 100 页）

本页收录第 8801–8900 条，共 10000 条 · 返回 生命科学 首页

• The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
  europepmc 2026 置信度 0.80
• Proteomics at scale: Bottlenecks and opportunities for early-career researchers in a fast developing field.
  europepmc 2026 置信度 0.80
• Spatium: A Protein Language Foundation Model for Spatial Proteomics
  europepmc 2026 置信度 0.80
• Anti-NSCLC mechanism of Inonotus obliquus polysaccharides revealed by combined metabolomics and proteomics.
  europepmc 2026 置信度 0.80
• Genome-guided stage- and tissue-resolved transcriptome analysis of Serrodes campana identifies sex-biased antennal expression and candidate chemosensory-related genes.
  europepmc 2026 置信度 0.80
• Morphological changes and transcriptomic insights into skeletal development of embryos and larvae of the sea urchin Strongylocentrotus intermedius.
  europepmc 2026 置信度 0.80
• Integrated proteomics and metabolomics reveal mechanisms of blood pressure reduction in spontaneously hypertensive rats under hypoxic conditions.
  europepmc 2026 置信度 0.80
• [Construction and analysis of a deep-coverage proteomic map of <i>Mycobacterium avium</i> based on high-resolution mass spectrometry].
  europepmc 2026 置信度 0.80
• Transcriptomic analysis provides molecular insights into the innate immune defense of Mactra veneriformis against Vibrio alginolyticus infection.
  europepmc 2026 置信度 0.80
• Beyond the Static Caliper: Dynamical Translocases and the Mathematical Imperative for Single-Molecule Proteomics
  europepmc 2026 置信度 0.80
• Plasma proteomics reveals continuous molecular heterogeneity rather than discrete subtypes in Alzheimer’s disease
  europepmc 2026 置信度 0.80
• Methionine Regulates Antitumour Function of CD8<sup>+</sup> T Cells Through Polyamine Synthesis.
  europepmc 2026 置信度 0.80
• Long-Chain S-Acylation Is a Key Modulator During the Macrophage Inflammatory Response.
  europepmc 2026 置信度 0.80
• SPgen: Proteome-wide Spatial Proteomics generation using multi-modality foundation models
  europepmc 2026 置信度 0.80
• Genome-wide identification and expression profiling of HSD3B and SDR42E1 genes in the Pacific oyster (Crassostrea gigas): potential associations with gonadal development.
  europepmc 2026 置信度 0.80
• A One Health Framework for Proteomics Across the Tree of Life to Advance Food Security, Animal Health, and Ecosystem Resilience.
  europepmc 2026 置信度 0.80
• Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy.
  europepmc 2026 置信度 0.80
• Proteome Profiling Reveals NQO2 Activity Contributing to Proteasome Inhibitor Resistance in Multiple Myeloma Cell Lines.
  europepmc 2026 置信度 0.80
• Instrument-Software Synergy in Proteomics: Systematic Evaluation across Mass Spectrometry Platforms, Search Engines, and Rescoring Methods.
  europepmc 2026 置信度 0.80
• Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Adverse Cardiovascular Outcomes in the General Population: Insights From the UK Biobank.
  europepmc 2026 置信度 0.80
• Proteomic analysis of malignant ascites and its impact on ovarian cancer spheroids.
  europepmc 2026 置信度 0.80
• Transcriptome analysis of the pectoral fin degeneration in half-smooth tongue sole (Cynoglossus semilaevis).
  europepmc 2026 置信度 0.80
• Toward simple, rapid, and deep plant proteome analysis with an in-cell proteomics strategy.
  europepmc 2026 置信度 0.80
• Alliin Regulates Intracellular Cholesterol Metabolism Through the PCSK9/LDLR Axis in Ox-LDL-Induced HepG2 Cells: A Proteomics Study.
  europepmc 2026 置信度 0.80
• The clinical promise of mass spectrometry-based single-cell proteomics: from bedside to bench.
  europepmc 2026 置信度 0.80
• Immuno-oncology: Decoding Tumor-immune Ecosystems with Multi-omics and Artificial Intelligence for Precision Therapeutics.
  europepmc 2026 置信度 0.80
• Integrated network analysis, proteomics, and experimental validation reveal the mechanisms underlying the renoprotective effects of salvianolic acid A against diabetic nephropathy.
  europepmc 2026 置信度 0.80
• Genomic identification and functional characterization of the nuclear receptor gene family in relation to sex determination and gonad development in the Pacific oyster (Crassostrea gigas).
  europepmc 2026 置信度 0.80
• Native Multidimensional Protein Complex Identification and Topology Characterization (Native MudPIT).
  europepmc 2026 置信度 0.80
• Proteome-wide Ubiquitinome Profiling Reveals Substrate-specific Dynamics Within the USP7 Network.
  europepmc 2026 置信度 0.80
• Proteomics in bone malignancies: from bulk profiling to single-cell and ultra-low-input technologies.
  europepmc 2026 置信度 0.80
• Integrative machine learning and transcriptomic analysis reveals molecular mechanisms underlying low survival rate in larval Chinese Bahaba (Bahaba taipingensis).
  europepmc 2026 置信度 0.80
• Optimizing NGN2 Dosage Enhances the Neuronal Enrichment of iPSC-Derived Neuronal Cultures.
  europepmc 2026 置信度 0.80
• Comparative transcriptome analysis reveals ncRNA-mediated regulatory networks associated with muscle crispiness in grass carp.
  europepmc 2026 置信度 0.80
• Patient-derived organoids in functional precision oncology: from experimental models to clinical decision-making.
  Despite major advances in high-throughput genomics, proteomics, and multimodal imaging, a substantial gap persists between molecular tumor characterization and clinically actionable therapeutic decision-making, partly due to the limitations of conventional pre…
  pubmed Caruso A, Delvecchio A, Memeo R, Lanzino M 等 2026 置信度 0.82
• Comparative Evaluation of Adaptive Focused Acoustics- and SP3-Based Workflows for Deep Proteomic Profiling of 30-Year-Old Formalin-Fixed Paraffin-Embedded Tissues.
  Formalin-fixed paraffin-embedded (FFPE) tissues represent a vast archive for translational research that offers access to specimens with clinical outcomes. However, formalin-induced crosslinking hinders efficient protein extraction and limits proteomic applica…
  pubmed Noguchi R, Ishii M, Adachi Y, Yoshimatsu Y 等 2026 Aug 6 置信度 0.82
• HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1-Mediated Mitochondrial Metabolism.
  Mitochondrial dysfunction and abnormal energy metabolism are important pathological features of Alzheimer's disease (AD). This study investigates how mitochondrial protease YME1L1 affects mitochondrial function and its upstream regulation in the pathogenesis o…
  pubmed Li X, Yang F, Jiang Y, Zhao F 等 2026 Aug 置信度 0.82
• Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin-based antivenom treatment on murine plasma proteome and peptidome.
  Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms…
  pubmed de Barros BCSC, Chaves AFA, Morone MSLC, Sachetto ATA 等 2026 Sep 置信度 0.82
• Platelet-released growth factors promote pro-angiogenic effects in endothelial cells: a translational perspective on wound healing and regenerative medicine.
  Platelet-Released Growth Factors (PRGF) are a standardized, cell- and fibrin-free platelet lysate with translational potential for tissue repair. PRGF enhance tissue regeneration, particularly in contexts where angiogenesis is critical for restoring perfusion …
  pubmed Singh M, Zitta K, Wedel T, Lucius R 等 2026 Aug 5 置信度 0.82
• Supplementation of αKG along with TGFβ/HIF1α antagonist rescues lung fibrosis in mice with severe SARS-CoV-2 infection.
  Pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are the clinical challenges among patients with post-acute sequelae of COVID-19 (PASC), affecting ~ 10% of the survivors worldwide. PASC manifestations include pulmonary fibrosis, …
  pubmed Joshi G, Parveen G, Kaur S, Asuru TR 等 2026 Aug 5 置信度 0.82
• The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.
  The cGAS-STING pathway is an evolutionarily conserved DNA-sensing mechanism that triggers innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, …
  pubmed Jardine J, Tarrillon M, André-Grégoire G, Trillet K 等 2026 Aug 5 置信度 0.82
• A covalent PFKL activator suppresses tumor growth.
  Glycolysis fuels vital cellular functions, and its dysregulation has been implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, represents a key vulnerability for developm…
  pubmed Jiang X, Lynch EM, Lyu C, Wilson CN 等 2026 Aug 5 置信度 0.82
• Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8.
  Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour-stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, th…
  pubmed Qian J, Tan Z, Wang J, Wei T 等 2026 Aug 5 置信度 0.82
• Plasma apolipoprotein A-IV deficiency as a proteomics-identified diagnostic biomarker for heat stroke: A prospective 2-center study.
  To explore proteomic changes from heat exhaustion (HE) to heat stroke (HS) and identify biomarkers for HS diagnosis.
  pubmed Zhou Y, Lin Q, He L, Zeng Q 等 2026 Jul 21 置信度 0.82
• Epigenetics, inflammation and postoperative complications: a scoping review.
  Excessive postoperative inflammation is associated with multisystem complications after surgery, culminating in morbidity, mortality and increased healthcare costs. Epigenetic modifications regulate gene transcription without altering DNA sequences and can aug…
  pubmed Wilson R, Fern C, Woolcock K, Goodyear C 等 2026 Aug 5 置信度 0.82
• Systematic Optimization of an SLE-DAPTAD LC-MS/MS Workflow for Simultaneous Quantification of Low-Abundance Vitamin D(3) Metabolites in Plasma.
  Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of vitamin D 3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix-associated, and have poor ionization efficiency. These limitations are p…
  pubmed Amirmostofian M, Wiese MD, Anderson PH, Hoffmann P 2026 Oct 30 置信度 0.82
• Loss of NCCRP1 overcomes immune evasion in lung adenocarcinoma.
  The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying mechanisms remain elusive. Here we identify non-spe…
  pubmed Liu L, Qi S, Shao L, Cai J 等 2026 Aug 5 置信度 0.82
• AP-3 complex sorts preferential cargo to govern dense core vesicle function in neuroendocrine cells.
  This study reveals the multifaceted role of the adaptor protein (AP-3) complex in the function of dense-core vesicles (DCVs). Despite numerous studies, an existing lack of knowledge concerning the role of AP-3 in DCV function prompted us to delve deeper. Bioch…
  pubmed Saxena S, Mukherjee C, Ghosh V, Chauhan BS 等 2026 Aug 5 置信度 0.82
• Surface shaving proteomics reveals a parasite-encoded protein embedded in the spore filaments of Ameson portunus.
  The surfaces of microsporidian spores are frequently adorned with filamentous appendages of unknown origin and function. Although some studies suggest that these structures may be host-acquired, the absence of identified parasite-encoded components has hindere…
  pubmed Fu M, Zhu H, Wang L, Wang Y 等 2026 Aug 5 置信度 0.82
• Adipocyte caspase-1 deficiency promotes white fat beiging via COX7A2L-dependent mitochondrial respiration.
  Beiging of white adipose tissue (WAT) is a promising strategy to enhance energy expenditure and combat obesity, a growing global health burden. Here, we identify a non-canonical role of caspase-1, a cysteine protease, in regulating adipocyte thermogenesis. Cas…
  pubmed Wang Y, Li J, He W, Zhao F 等 2026 Aug 5 置信度 0.82
• Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.
  Type 2 diabetes mellitus (T2DM) and major depressive disorder (MDD) are reciprocal risk factors, and both elevate dementia risk. Dysregulation of programmed cell death is implicated in T2DM, MDD, and neurodegeneration, but proteomic markers of apoptosis have y…
  pubmed Perfetto SE, Ruthirakuhan M, Wong YY, Ryoo SW 等 2026 Aug 5 置信度 0.82
• Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in sepsis.
  Sepsis is a life-threatening condition resulting from organ dysfunction due to a dysregulated immune response to infection. Immunoglobulin G (IgG) play a role in modulating immune responses. However, the precise IgG subclass-specific N-glycosylation profiles i…
  pubmed Li L, Long T, Liu Y, Lai S 等 2026 Aug 5 置信度 0.82
• Integrated DIA proteomics of tissue and exudate reveals screening markers for early detection of ulcerative colitis and colorectal cancer.
  Early detection biomarkers are needed to support the timely detection and monitoring of ulcerative colitis (UC) and its potential association with colorectal cancer (CRC). We used Data-Independent Acquisition (DIA) proteomics on paired colorectal tissue and ex…
  pubmed Gong Q, Wang J, Ke Q, Du S 等 2026 Aug 5 置信度 0.82
• Propranolol attenuates systemic inflammatory response in aged traumatic brain injury patients.
  Aged traumatic brain injury (TBI) patients typically have a worse prognosis than younger individuals, though the underlying mechanisms remain incompletely understood. Secondary neuroinflammation is a key determinant of outcomes following TBI, but how aging res…
  pubmed Zhu Y, Lu Z, Wang C, Zhu X 等 2026 Aug 5 置信度 0.82
• Pro-developmental role of AMPK-PINK1/Parkin-mediated mitophagy in the morula-to-blastocyst transition during early embryonic development: Dual-omics evidence for the beneficial effects of GSH.
  Early embryonic development depends on precise redox homeostasis and mitochondrial quality control; however, how AMPK regulates embryonic fate through mitophagy remains unclear. In this study, integrated transcriptomic and proteomic analyses of Tibetan sheep e…
  pubmed Li T, Bai X, Liao Y, Zuo Q 等 2026 Aug 3 置信度 0.82
• Pan-cancer multi-omics machine learning defines a lactylation-associated immune-excluded tumor state with proteomic and experimental corroboration.
  Histone lactylation links lactate metabolism to chromatin regulation, but whether lactylation-program-associated transcriptional patterns delineate recurrent pan-cancer tumor states remains unclear.
  pubmed Bo Z, Zhang S, Zheng Z, Ma J 等 2026 Jul 31 置信度 0.82
• Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via promoting bile acid reabsorption and decreasing focal adhesion kinase signaling revealed by metabolomics and proteomics.
  Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate chemotherapy-induced diarrhea, but its underlying mechanisms remain u…
  pubmed He Z, Chen Y, Qiu H, Zhou R 等 2026 Jul 30 置信度 0.82
• Paris saponin VII promotes TRIP12-mediated SOD1 degradation to synergize with idarubicin in ROS-dependent acute myeloid leukemia cell death.
  Acute myeloid leukemia (AML) cells evade apoptosis through antioxidant mechanisms. Paris saponin VII (PS VII), a steroidal saponin, exhibits antitumor activity in solid malignancies, but its role in AML remains unclear.
  pubmed Ni R, Ding N, Shi Y, Liu M 等 2026 Jul 29 置信度 0.82
• A clinical and experimental investigation of liraglutide effects on the brain-kidney axis.
  Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before…
  pubmed Greenwood MP, Alotaibi MI, Bárez-López S, Cantley NWP 等 2026 Aug 7 置信度 0.82
• Systematic profiling of nudivirus-like genes reveals conserved and differentiated roles in a domesticated endogenous virus.
  Cotesia vestalis bracovirus (CvBV) is a type of domesticated endogenous virus (DEV) derived from ancestral nudiviruses that is integrated into the genome of the parasitoid wasp Cotesia vestalis. The CvBV proviral genome is composed of two distinct components: …
  pubmed Zhou Y, Ding K, Zhang S, Yang X 等 2026 Aug 5 置信度 0.82
• The role of transglutaminase 2 in stabilizing fibrin clots and supporting hemostasis.
  Transglutaminases are enzymes with pleiotropic functions in the human body, among them are the A-subunit of coagulation factor XIII (FXIII; FXIII-A) and tissue transglutaminase (TG2). FXIII has a crucial function in clot formation and stabilization. FXIII also…
  pubmed Stoklosa P, Suzuki R, Golomingi M, Li B 等 2026 置信度 0.82
• Characterization of Matrix-Adapted PEG Isolation of Exosome-Like Nanovesicles from Pandanus conoideus.
  Plant-derived exosome-like nanovesicles (PDENs) have recently gained prominence as biocompatible, renewable nanocarriers, but lipid-dense tropical plants remain an underutilized vesicle reservoir and present substantial hurdles for efficient isolation. Here, w…
  pubmed Rahmawaty L, Az Zahra AN, Wungu TDK, Barlian A 等 2026 Jul 28 置信度 0.82
• Harnessing the gut microbiome to combat tuberculosis: a technological and clinical review.
  Tuberculosis (TB), especially multidrug-resistant and extensively drug-resistant strains, remains a severe global health threat. Advances in high-throughput sequencing, omics technologies and artificial intelligence have revealed the critical involvement of th…
  pubmed Sun W, Xiao M, Ali SL, Jin C 等 2026 置信度 0.82
• Circulating cochlin LCCL domain binds to dying cells and enhances efferocytosis.
  Clearance of dead cells by efferocytosis is a critical process for homeostasis, notably by limiting inflammation. Defective efferocytosis has been associated with autoimmune, neurodegenerative, and cardiovascular diseases, as well as chronic infections, making…
  pubmed Courcol L, Hassan A, Haftek-Terreau Z, Vigneron C 等 2026 Aug 4 置信度 0.82
• Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach.
  Here, we provide a protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach. We describe steps for fusing amino- and carboxyl-terminal fragments of the biotin ligase TurboID to proteins…
  pubmed Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Trinkle-Mulcahy L 2026 Aug 4 置信度 0.82
• Dynamic protein expression in golden hamster oocytes and embryos reveals extensive post-translational regulation of PIWIL1 during the oocyte-to-embryo transition.
  The golden hamster, renowned for its representative PIWI-piRNA pathway profile among mammals, has emerged as a promising animal model for investigating female mammalian fertility. Prior research uncovered that the disruption of Piwil1 leads to complete inferti…
  pubmed Liang S, Lu J, Qin R, Zhang J 等 2026 Aug 5 置信度 0.82
• Rapid Serum Proteome Profiling of Glycation and N-Glycosylation in Women with a History of Gestational Diabetes.
  Here, we developed and validated a high throughput proteomics workflow that enables combined profiling of global proteomes and post-translational modifications (PTMs) without conventional enrichment or fractionation. Using mass spectrometry-based methods, we i…
  pubmed Philip T, Kale S, Partlow S, Wallenius K 等 2026 Aug 5 置信度 0.82
• TREM2 Deficiency Attenuates Endometriosis Progression by Inhibiting M2 Polarization of SpMs and Suppressing SIRPα to Enhance Phagocytosis.
  Endometriosis (EMS) is characterised by a disrupted peritoneal immune microenvironment where M2 macrophage polarization and impaired phagocytosis promote lesion survival. Single-cell RNA-seq (ScRNAseq) of the peritoneal macrophages from EMS patient revealed el…
  pubmed Mo Q, Lin Y, Hao L, Zhang L 等 2026 Aug 5 置信度 0.82
• Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis.
  Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progres…
  pubmed Lv S, Shen Z, Gu Y, Wang Y 等 2026 Aug 5 置信度 0.82
• Integrating multi-omics with regular analyses to elucidate the effects of ZnO nanomaterials on improving soybean quality.
  With rising global demand for high-quality food crops, soybean production is constrained by an inherent yield-quality trade-off that conventional practices cannot easily overcome. Zinc oxide nanomaterials (ZnO NMs) show great potential for crop improvement, bu…
  pubmed Hu X, Zhao Y, Cai S, Zhang Y 等 2026 Aug 5 置信度 0.82
• Angiosarcoma: adaptive designs leveraging vascular biology and antiangiogenic repurposing.
  Angiosarcoma is a rare and aggressive vascular malignancy characterized by substantial clinical and molecular heterogeneity. Grouping UV-associated cutaneous, radiation-associated, and visceral tumors within unselected clinical trials may obscure treatment eff…
  pubmed Iich E, Kannan B, Law YC, Chan JY 2026 Aug 5 置信度 0.82
• Single-Cell Proteomics Reveals Proteome Remodeling and Cellular Heterogeneity During NGF-Induced PC12 Neuronal Differentiation.
  Single-cell proteomics enables direct measurement of cellular heterogeneity during dynamic biological processes, but its application to fragile and highly adherent neuronal models remains challenging. Here, we developed and applied an optimized single-cell pro…
  pubmed Ebrahimi A, Chi S, Yang J, Lee PY 等 2026 Aug 5 置信度 0.82
• Micropharmacology Beyond Target Expression: Mapping Barriers to Intra-Tumoral Drug Delivery.
  High dimension spatial technologies are broadly being used to map the cellular and molecular organization of human cancers including tumor antigens and drug targets. This has revealed extensive spatial heterogeneity of target proteins, but does not quantify dr…
  pubmed Jackson H 2026 Aug 5 置信度 0.82
• The FleQ-FleN circuit balances flagellar number against fitness in Pseudomonas aeruginosa.
  Evolutionary constraints governing flagellar number in bacterial pathogens remain poorly understood. While related Pseudomonas species are hyperflagellated, Pseudomonas aeruginosa maintains strict monoflagellation through the FleQ-FleN regulatory circuit. Here…
  pubmed Migueles-Lozano A, Asp M, Rocha ST, Li J 等 2026 Aug 5 置信度 0.82
• Epigenetic aging in Alzheimer's disease: Relation to proteome.
  Alzheimer's disease (AD) arises from heterogeneous biological processes, and long-term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.
  pubmed Kim BH, Lee H, Kim J, Seo SW 等 2026 Aug 置信度 0.82
• The association of cardiovascular health with new-onset pulmonary hypertension and the mediating role of proteomic signatures.
  The cardiovascular health (CVH) metrics have been reported to play an important role in the development of noncommunicable chronic diseases, yet its link to pulmonary hypertension (PH) risk and the underlying biological mechanisms remain unclear. This study ai…
  pubmed Zhang MJ, Bo YC, Shi JZ, Xu MD 等 2026 Jul 28 置信度 0.82
• MODY Mutations in Transcription Factors HNF1A and HNF1B Affect the Production of Interferon Signaling Proteins: Evidence at the Proteome Level.
  This discovery study investigated the impact of MODY-associated mutations in hepatocyte nuclear factors HNF1A and HNF1B on the cellular proteome, aiming to identify affected pathways and advance understanding of diabetes pathogenesis. Human induced pluripotent…
  pubmed Kuznetsova KG, Vašíček J, Skiadopoulou D, Unger L 等 2026 Aug 5 置信度 0.82
• Advances in Nucleic Acid-Based Amplification Strategies for Dual-Mode Biosensing of Pathogenic Bacteria: From Molecular Mechanisms to Integrated Analytical Systems.
  Rapid, accurate, and reliable detection of pathogenic bacteria remains a critical need in clinical, food, and environmental monitoring. In today's context, nucleic acid amplification-mediated biosensing have emerged as a prominent approach to improve detection…
  pubmed Jalal Balaky ST, Alwash BH, Sadiq Zamzamokey FF, Ali Khaleel A 等 2026 Aug 5 置信度 0.82
• Bayesian joint additive factor models for multiview learning.
  It is increasingly common to collect data of multiple different types on the same set of samples. Our focus is on studying relationships between such multiview features and responses. A motivating application arises in the context of precision medicine where m…
  pubmed Anceschi N, Ferrari F, Dunson DB, Mallick H 2026 Jul 1 置信度 0.82
• Mast Cell St8sia1 Is a Glyco-Epigenetic Checkpoint Driving Cardiac Remodeling.
  Pathogenic immune-cardiac crosstalk underlies maladaptive remodeling in chronic heart failure, yet therapies directly targeting this axis are lacking. Glycoconjugates, which are crucial for signal transduction and extracellular matrix integrity, represent an u…
  pubmed Zhou C, Fu L, Yuan T, Li F 等 2026 Aug 5 置信度 0.82
• Pleiotropic roles of the MATE transporter CD20030 in Clostridioides difficile: linking multidrug resistance to oxidative stress defense and virulence regulation.
  The multidrug-resistant pathogen Clostridioides difficile ( C. difficile ) presents a persistent clinical threat. While Multidrug and Toxic Compound Extrusion (MATE) transporters are recognized as xenobiotic efflux pumps, their pleiotropic roles in pathogen ph…
  pubmed Deng J, Chen FH, Wu WJ, Huang TY 等 2026 置信度 0.82
• Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases.
  Blood can clot into anomalous, fibrinolysis-resistant forms that arise from prothrombotic seeding areas, including damaged cellular debris and membrane-derived surfaces, giving rise to what we have termed fibrinaloid microclot complexes (colloquially: microclo…
  pubmed Grixti J, Pretorius E, Kell DB 2026 置信度 0.82
• Assessment of Allergenic Potential for Cross-Reactivity of Olive (Olea europaea) Pit Xylo-Oligosaccharide-Rich Extract With Legislated Allergens in the European Union.
  Novel food sources must undergo allergenicity assessments to ensure consumer safety and regulatory compliance. Xylo-oligosaccharide-rich extract (XOS) derived from the valorization of olive ( Olea europaea ) pit is categorized as a novel food in the context of…
  pubmed Manful ME, O'Shea J, Torres A, Otero P 等 2026 Aug 置信度 0.82
• Potential Drug Targets and Causal Plasma Proteins Related to Preeclampsia Identified by Mendelian Randomization.
  Preeclampsia (PE) is a complication of pregnancy characterized by hypertension, with limited therapeutic options and variable treatment response. Identifying novel drug targets is urgently needed.
  pubmed Zhou W, Huang T, Li L, Shen Y 等 2026 Jan-Dec 置信度 0.82
• Unraveling the Molecular Landscape of Follicular Fluid: A Comparative Proteomic Study Between Bali and Brahman Cattle.
  Protein biomarkers are increasingly recognized as indicators of metabolic status, immune response, and reproductive performance in cattle. However, comparative data among different breeds commonly raised in Indonesia remain limited.
  pubmed Gustina S, Hasbi H, Azis IU, Maulana T 等 2026 置信度 0.82
• HO-1 Up-regulation and PINK1/Parkin-Mediated Mitophagy Contribute to the Anti-tumor Effects of Metochalcone in Colorectal Cancer.
  Colorectal cancer (CRC) remains a global health challenge with rising incidence in younger populations and limited efficacy of current chemotherapies. In this study, we investigated the anti-tumor mechanisms of metochalcone (MET), a natural chalcone derivative…
  pubmed Chen P, An J, Han M, Wang Y 等 2026 置信度 0.82
• Fractal and Machine Learning Analyses of MALDI-TOF Mass Spectrometry Data in Glioblastoma.
  Data preprocessing is a critical step in the analysis of matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) spectra for machine learning applications, typically involving steps such as spectra trimming, baseline correct…
  pubmed Lazari LC, Azemi G, Russo C, Rosa-Fernandes L 等 2026 置信度 0.82
• Curcumin Attenuates Decidual Stromal Cell Ferroptosis and Restores Impaired Decidualization in Recurrent Spontaneous Abortion by Targeting BRD4.
  Recurrent spontaneous abortion (RSA) is a major reproductive health challenge with limited clinical options. Curcumin, a natural polyphenol widely consumed as a dietary supplement, has shown promise in improving pregnancy outcomes; however, its specific molecu…
  pubmed Ma Y, Chen W, Xie T, Wu Y 等 2026 Aug 置信度 0.82
• Beta-casein in human milk is associated with infant stool frequency: A pilot proteomics study.
  Breast milk proteins may regulate gut function and defecation frequency; however, their specific roles in these processes remain poorly understood. We hypothesized that variations in specific human milk proteins are associated with differences in stool frequen…
  pubmed Li ZH, Xie ZR, Li M, Xiong JJ 等 2026 Aug 置信度 0.82
• Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation.
  Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed pl…
  pubmed He J, Liu X, Tang J, Tang C 等 2026 Aug 4 置信度 0.82
• Multidimensional Protein Corona Analysis Toward Predictive Nano-Bio Interface Design.
  Nanoparticles entering biological fluids are rapidly coated by proteins and other biomolecules, converting their synthetic surfaces into biologically active nano-bio interfaces. These coronas regulate colloidal stability, immune recognition, cellular uptake, b…
  pubmed Hou M, Chen M, Liu S 2026 Aug 4 置信度 0.82
• Evidence that S-phase kinase associated protein 2 (SKP2) is ubiquitinated and degraded via a Rho-related BTB domain containing 1 (RhoBTB1) and Cullin-3 mechanism in placenta.
  Rho related BTB domain containing 1 (RhoBTB1) is highly expressed in placenta and functions to deliver protein targets to the Cullin-3 (CUL3) E3 ubiquitin ligase where they are targeted for ubiquitination and degradation. The targets of RhoBTB1 in placenta hav…
  pubmed Tvina AL, Livergood MC, Kumar G, Hole VW 等 2026 Aug 置信度 0.82
• Yiqi Huoxue Jiedu formula protects against sepsis-associated lung injury by modulating macrophage mitophagy and mtDNA-STING signaling.
  Yiqi Huoxue Jiedu Formula (YHJF) is a traditional Chinese medicine formula that has been used as an adjunctive therapy for sepsis for nearly two decades. Previous clinical studies showed that YHJF improves Sequential Organ Failure Assessment (SOFA) scores and …
  pubmed Ma S, Pan Q, Lin J, Zeng R 等 2026 Aug 4 置信度 0.82
• IFI6 is associated with interferon activation and complement-associated immune responses in primary Sjögren's disease.
  Primary Sjögren's disease (pSjD) is a systemic autoimmune disease characterized by chronic immune-mediated inflammation of exocrine glands and a prominent type I interferon (IFN-I) signature. However, the molecular mechanisms linking interferon signaling …
  pubmed Han Y, Mei Y, Meng X, Zhang M 等 2026 Aug 5 置信度 0.82
• CDK2-mediated phosphorylation of TRF1 S11 facilitates DNA damage repair by remodeling telomeric chromatin.
  Telomeres, coated by the shelterin complex, prevent end-to-end fusions and aberrant DNA repair, yet how telomere-binding proteins coordinate chromatin remodeling during the DNA damage response remains unclear. Here we show that the telomeric protein TRF1 is ph…
  pubmed Zhou X, Wang M, Hu W, Chen Z 等 2026 Aug 4 置信度 0.82
• A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.
  Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions, but limitations in reproducibility, maturation and cell-type diversity persist. Especially, prolonged incorporation of mature microglia and stud…
  pubmed Klimmt J, Cardoso Gonçalves C, Montgomery JV, Müller SA 等 2026 Aug 4 置信度 0.82
• Proteomics in cardiology: research and practice.
  Despite recent advances in prevention and treatment, cardiovascular disease (CVD) remains a leading cause of premature death and disability globally, with a rising burden in many low- and middle-income countries. Several modifiable determinants of CVD are well…
  pubmed Fry H, Im PK, Yao P, Wang B 等 2026 Aug 4 置信度 0.82
• Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS.
  Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknow…
  pubmed Ridžal L, Frieling T, Róka R, Inczefi O 等 2026 Aug 4 置信度 0.82
• Tumor-derived CDHR2-enriched extracellular vesicles engage ANPEP on liver sinusoidal endothelial cells to facilitate transendothelial migration in PDAC.
  Liver metastasis is the leading cause of death in pancreatic ductal adenocarcinoma (PDAC), yet its molecular drivers remain poorly defined. Through integrated transcriptomic and proteomic screening of clinical specimens, we identify the membrane protein Cadher…
  pubmed Wang R, Wang Y, Xiao S, Liao S 等 2026 Aug 4 置信度 0.82
• Serum-Free Expanded Hair Follicle Mesenchymal Stem Cells Promote Cartilage Repair in a Murine Full-Thickness Defect Model.
  ▒: Serum-free expanded hair follicle mesenchymal stem cells (hfMSCs) maintained mesenchymal phenotype and multipotency during static and stirred suspension bioreactor (SSB) expansion and promoted histological cartilage repair in a murine full-thickness …
  pubmed Sun H, Gysel E, Larijani L, Young D 等 2026 Aug 4 置信度 0.82