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• A streamlined workflow for high throughput metaproteomic analysis of the rumen microbiome.
  Metaproteomics can provide direct functional insights into complex microbial communities, yet its application in rumen research remains limited due to labor-intensive and low-throughput sample preparation workflows before the MS analysis. This work aimed to de…
  pubmed Pedersen AL, Dayon L, Affolter M, Seifert J 2026 Aug 4 置信度 0.82
• Species- and heat-dependent variability in shrimp allergens revealed by quantitative proteomics: Implications for risk assessment.
  Shellfish allergy is a major cause of food-induced severe adverse reactions worldwide, with shrimp representing one of the most implicated triggers. Detection and monitoring of allergenic proteins in shrimp-containing foods rely largely on immunoassay-based de…
  pubmed Karnaneedi S, Poly T, Heidari S, Jerry E 等 2026 Aug 4 置信度 0.82
• Coixol attenuates Ulcerative Colitis by modulating the ILC3 response via the Wnt/β-catenin pathway.
  Coicis Semen is a classic example of a resource used both as food and medicine. In traditional Chinese medicine, it is known for several functions: promoting diuresis, resolving dampness, strengthening the spleen, stopping diarrhea, draining pus, and removing …
  pubmed Ma J, Yin Q, Zhou Y, Chen W 等 2026 Aug 4 置信度 0.82
• Sugar-coded signals: Glycan-based biomarkers in rheumatoid arthritis.
  This review paper summarises the pathophysiology of rheumatoid arthritis (RA), its incidence and aetiology, and conventional RA protein-based biomarkers. A brief overview of novel protein-based biomarkers and biomarkers with potential to be used in the diagnos…
  pubmed Hires M, Hroncekova S, Dujnič V, Vrablova V 等 2026 Aug 4 置信度 0.82
• Systematic Workflow Optimization for Ultra-Sensitive Targeted Immunopeptidomics.
  Epitope detection sensitivity remains a primary bottleneck in mass spectrometry (MS)-based immunopeptidomics, as conventional discovery-based workflows such as data-dependent (DDA) and data-independent acquisition (DIA) frequently lack the sensitivity required…
  pubmed Förster JD, Becker JP, Vučković N, Riemer AB 2026 Aug 4 置信度 0.82
• Proteomic insights of peripheral artery disease across the glycemic spectrum: a prospective cohort study.
  Peripheral artery disease (PAD) risk varies substantially across glycemic states, but glycemic status-specific proteomic features of PAD remain poorly characterized. This study aimed to provide comprehensive proteomic insights into PAD risk across the glycemic…
  pubmed Yu H, Zhang J, Qian F, Zhu K 等 2026 Aug 4 置信度 0.82
• Brain metastasis-associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion.
  Brain metastases (BrM) are a frequent and life-threatening complication of solid tumours, with lung cancer representing their most common source. While cancer-associated fibroblasts (CAFs) are well-established contributors to tumour progression in many extracr…
  pubmed Výmolová B, Pfeiferová L, Smetana TK, Výmola P 等 2026 Aug 4 置信度 0.82
• Plasma proteomics linking primary and secondary diseases: Insights into molecular mediation from UK Biobank data.
  Diabetes, hypertension, and dyslipidemia are major risk factors for cardiovascular, neurological, renal, and pulmonary diseases, yet clinically accessible molecular mediators linking these cardiometabolic conditions to downstream complications remain unclear.
  pubmed Qian H, Wu C, Li B, Rosenzweig A 等 2026 Aug 4 置信度 0.82
• Cr(VI) stress induces carbon-nitrogen metabolic reprogramming in Penicillium oxalicum SL2.
  Hexavalent chromium [Cr(VI)] detoxification by fungi is environmentally important, yet the metabolic basis that sustains extracellular non-enzymatic Cr(VI) reduction remains elusive. This study investigated extracellular Cr(VI) reduction and metabolic reprogra…
  pubmed Luo Y, Yang Y, Fang Y, Xu X 等 2026 Jul 29 置信度 0.82
• Enrichment of Akkermansia muciniphila by red ginseng promotes GDF15 secretion and suppresses obesity in mice.
  Obesity is a growing global health burden with rising incidence. Red ginseng (RGS), a traditional processed ginseng product, shows potential for improving metabolic parameters, though its anti-obesity mechanism remains incompletely understood.
  pubmed Zhuang T, Wang X, Zheng W, Lu W 等 2026 Jul 15 置信度 0.82
• Celastrol Ameliorates Systemic Lupus Erythematosus via Restoring Nt5e/ adenosine-dependent Th17/Treg Balance.
  Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the breakdown of immune tolerance, systemic inflammation, and multi-organ damage. The imbalance between T helper 17 (Th17) cells and regulatory T (Treg) cells is a key driver i…
  pubmed Jiang Z, Li S, Li Y, Wang C 等 2026 Jul 15 置信度 0.82
• Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance.
  Platinum resistance remains a major therapeutic challenge in ovarian cancer (OC) and is one of the main causes leading to disease relapse and mortality. Although PARP inhibitors have improved outcomes for a subset of patients, most women continue to rely on pl…
  pubmed Gudoityte G, Berkovska O, Orre LM, Moussaud-Lamodière E 等 2026 Aug 4 置信度 0.82
• Multi-omics integration unravels four molecular subgroups of corticotroph pituitary neuroendocrine tumours with distinct clinicopathological features.
  Corticotroph pituitary neuroendocrine tumours (PitNETs)/adenomas are heterogeneous sellar neoplasms. Currently established histopathological classification approaches are often considered limited in fully capturing the clinical and biological complexity of the…
  pubmed Dottermusch M, Ryba A, Gocke A, Rafiq T 等 2026 Aug 4 置信度 0.82
• Parity and dietary energy regulate IgG and non-IgG bioactive proteins in colostrum of beef cattle.
  Bovine colostrum provides crucial immune and developmental support to newborn calves, yet the roles of non-immunoglobulin bioactive proteins remain underexplored. The objective of this study was to characterize the colostrum proteome and evaluate the effects o…
  pubmed Cirone K, Hare K, Wood KM, Young D 等 2026 Jul 14 置信度 0.82
• Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments.
  Across cancer, one of the most frequent examples of histologic transformation is the evolution of follicular lymphoma (FL) to an aggressive large cell lymphoma. Despite recent progress, understanding of the molecular and cellular underpinnings of transformatio…
  pubmed Haradhvala NJ, Yiu SPT, Beckmann L, Sadigh S 等 2026 Aug 4 置信度 0.82
• A reference protein atlas of the adult mouse brain vasculature.
  Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-cell RNA sequencing (scRNA-seq) data, which can be misleading due to the poor cross-gene correlation (different gen…
  pubmed He L, Johansson HJ, Vazquez-Liebanas E, Liu J 等 2026 Aug 11 置信度 0.82
• A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.
  The replacement of a single codon in the human prion gene, causing the substitution of glycine with valine at position 127 (G127V) of the prion protein (PrP), prevents development of prion disease. We set out to explore if prion disease survival extension mani…
  pubmed Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S 等 2026 Aug 4 置信度 0.82
• In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila.
  Much focus has shifted towards understanding how glial dysfunction contributes to age-related neurodegeneration due to the critical roles glial cells play in maintaining brain health. Cell-cell interactions, which are largely mediated by cell-surface proteins,…
  pubmed Marques MP, Sun B, Park YJ, Jackson T 等 2026 Aug 18 置信度 0.82
• Bepirovirsen induces innate immune proteins independent of HBV.
  Bepirovirsen, an antisense oligonucleotide that targets all hepatitis B virus (HBV) mRNAs, is in development for the treatment of chronic HBV infection. Clinical studies have demonstrated that bepirovirsen has multiple mechanisms of action, including lowering …
  pubmed Delahaye JL, You S, Fu K, Van Buren S 等 2026 Aug 4 置信度 0.82
• The maternal gut microbiota influences myocardial maturation and diastolic function of offspring in mice.
  Although the maternal microbiome is recognized as a critical regulator of offspring physiology, its role in heart development and the pathogenesis of heart failure remains largely unclear. Using a germ-free (GF) mouse model, we demonstrated that maternal micro…
  pubmed Li S, Zhang Y, Li Y, Lei Y 等 2026 Jul 31 置信度 0.82
• METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress.
  Chronic stress contributes to hippocampal neuronal apoptosis and neural circuit dysfunction in major depressive disorder (MDD), but the epitranscriptomic mechanisms regulating stress-responsive microRNAs remain unclear. This study investigated whether methyltr…
  pubmed Zhang Y, Du X, Fu M, Hu H 等 2026 Aug 4 置信度 0.82
• Integrated DIA-PRM proteomics Deciphers the molecular mechanisms and identifies core biomarkers of relative resistance to decapod iridescent Virus 1 (DIV1) in Macrobrachium rosenbergii.
  Macrobrachium rosenbergii is a pillar species in global freshwater crustacean aquaculture. Decapod iridescent virus 1 (DIV1) causes 60%-90% cumulative mortality in cultured ponds, leading to massive economic losses with no effective control measures. This stud…
  pubmed Xu Y, Wu C, Fan Y, Yu C 等 2026 Aug 4 置信度 0.82
• Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation.
  In multiple sclerosis (MS), the chronic, unresolved nature of neuroinflammation within the central nervous system (CNS) remains a major obstacle for effective therapeutic intervention. This challenge arises primarily due to an incomplete understanding of the d…
  pubmed Konings J, Mingneau F, Chornyi S, Hansen CE 等 2026 Aug 4 置信度 0.82
• Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation.
  During myogenic differentiation, the cellular architecture and proteome of muscle stem cells and myoblasts undergo extensive remodeling. These processes are partially understood and display alterations in disease and aging, resulting in impaired regeneration. …
  pubmed Späth E, Schüler SC, Heinze I, Dau T 等 2026 Aug 4 置信度 0.82
• An integrated proteomics and transcriptomics analysis highlights concordance between protein turnover and carbohydrate transport and metabolism as key functional categories during the growth of Trichophyton rubrum.
  Dermatophytes are a class of keratinophilic skin fungi that invade host skin, hair, and nails to acquire nutrients. An integrated multi-omics approach utilizing liquid chromatography-tandem mass spectrometry and RNA-seq after growth in a protein-rich soy mediu…
  pubmed Singh H, Latka C, Chakraborty R, Dhingra L 等 2026 Aug 4 置信度 0.82
• SpxA1 and SpxA2 function as a stoichiometry-dependent regulatory rheostat governing virulence gene expression in group A Streptococcus.
  Group A Streptococcus (GAS) is a human-restricted pathogen whose global incidence has surged in the post-COVID era. The ability of GAS to shift from a colonizing to invasive phenotype depends on coordinated virulence gene regulation in response to host-derived…
  pubmed Morrison GA, Vega LA, Sanson Iglesias M, Holly K Jr 等 2026 Aug 4 置信度 0.82
• Immuno-oncology: Decoding Tumor-immune Ecosystems with Multi-omics and Artificial Intelligence for Precision Therapeutics.
  pubmed Ye Y, Guo AY, Liu S, Xing Y 2026 Aug 4 置信度 0.82
• Alternative splicing: increasing diversity in the proteomic world
  openalex Brenton R. Graveley 2001-02-01 置信度 0.72 BiologyProteomeAlternative splicingCaenorhabditis elegansGene
• ProteomeXchange provides globally coordinated proteomics data submission and dissemination
  openalex Juan Antonio Vizcaíno, Eric W. Deutsch, Rui Wang, Attila Csordás 等 2014-03-01 置信度 0.72 ProteomicsComputational biologyData scienceComputer scienceBiology
• Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data
  Protein networks have become a popular tool for analyzing and visualizing the often long lists of proteins or genes obtained from proteomics and other high-throughput technologies. One of the most popular sources of such networks is the STRING database, which …
  openalex Nadezhda T. Doncheva, John H. Morris, Jan Gorodkin, Lars Juhl Jensen 2018-11-19 置信度 0.72 ProteomicsVisualizationComputer scienceComputational biologyData visualization
• MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics
  openalex Andy T. Kong, Felipe da Veiga Leprevost, Dmitry M. Avtonomov, Dattatreya Mellacheruvu 等 2017-04-10 置信度 0.72 Database search engineProteomicsProteomeMass spectrometryComputational biology
• Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
  Extracellular vesicles (EVs) have become the focus of rising interest because of their numerous functions in physiology and pathology. Cells release heterogeneous vesicles of different sizes and intracellular origins, including small EVs formed inside endosoma…
  openalex Joanna Kowal, Guillaume Arras, Marina Colombo, Mabel Jouve 等 2016-02-08 置信度 0.72 Extracellular vesiclesExtracellular vesicleExtracellularBiologyComputational biology
• Identification and proteomic profiling of exosomes in human urine
  Urine provides an alternative to blood plasma as a potential source of disease biomarkers. One urinary biomarker already exploited in clinical studies is aquaporin-2. However, it remains a mystery how aquaporin-2 (an integral membrane protein) and other apical…
  openalex Trairak Pisitkun, Rong‐Fong Shen, Mark A. Knepper 2004-08-23 置信度 0.72 MicrovesiclesPKD1VesicleBiologyExosome
• Semi-supervised learning for peptide identification from shotgun proteomics datasets
  openalex Lukas Käll, Jesse D. Canterbury, Jason Weston, William Stafford Noble 等 2007-10-21 置信度 0.72 Shotgun proteomicsShotgunProteomicsTandem mass spectrometryIdentification (biology)
• The Proteomics Identifications (PRIDE) database and associated tools: status in 2013
  The PRoteomics IDEntifications (PRIDE, http://www.ebi.ac.uk/pride) database at the European Bioinformatics Institute is one of the most prominent data repositories of mass spectrometry (MS)-based proteomics data. Here, we summarize recent developments in the P…
  openalex Juan Antonio Vizcaíno, Richard G. Côté, Attila Csordás, José A. Dianes 等 2012-11-29 置信度 0.72 PrideProteomicsContext (archaeology)BiologyPipeline (software)
• Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
  Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-spec…
  openalex Linn Fagerberg, Björn M. Hallström, Per Oksvold, Caroline Kampf 等 2013-12-05 置信度 0.72 Human Protein AtlasTranscriptomeProteomicsComputational biologyBiology
• ProteoWizard: open source software for rapid proteomics tools development
  SUMMARY: The ProteoWizard software project provides a modular and extensible set of open-source, cross-platform tools and libraries. The tools perform proteomics data analyses; the libraries enable rapid tool creation by providing a robust, pluggable developme…
  openalex Darren Kessner, Matt Chambers, Robert Burke, David B. Agus 等 2008-07-07 置信度 0.72 Computer scienceDocumentationModular designSoftwareSource code
• Proteomic analysis of post-translational modifications
  openalex Matthias Mann, Ole N. Jensen 2003-02-28 置信度 0.72 Posttranslational modificationComputational biologyMass spectrometryEukaryoteProteomics
• A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
  Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid chromatography in combination with tandem mass spectrometry is a standard approach in biological studies. Data-dependent acquisition is used to automatically acquire tandem m…
  openalex Hongbin Liu, Rovshan G. Sadygov, John R. Yates 2004-06-02 置信度 0.72 ChemistryShotgun proteomicsShotgunMass spectrometrySampling (signal processing)
• Quantitative mass spectrometry in proteomics: a critical review
  The quantification of differences between two or more physiological states of a biological system is among the most important but also most challenging technical tasks in proteomics. In addition to the classical methods of differential protein gel or blot stai…
  openalex Marcus Bantscheff, Markus Schirle, Gavain M.A. Sweetman, Jens M. Rick 等 2007-07-31 置信度 0.72 Mass spectrometryProteomicsQuantitative proteomicsChemistryLabel-free quantification
• Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
  BACKGROUND: The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine. METHODOLOGY/PRINCIPAL FINDINGS: We present a new aptamer-based proteomic technology for bioma…
  openalex Larry Gold, Deborah Ayers, Jennifer Bertino, C. Bock 等 2010-12-07 置信度 0.72 AptamerBiomarker discoveryProteomeProteomicsComputational biology
• A proteomics approach to understanding protein ubiquitination
  openalex Junmin Peng, Daniel Schwartz, Joshua E. Elias, Carson C. Thoreen 等 2003-07-18 置信度 0.72 UbiquitinTandem affinity purificationProteomicsUbiquitin-conjugating enzymeLysine
• Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
  openalex Joseph D. Mancias, Xiaoxu Wang, Steven P. Gygi, J. Wade Harper 等 2014-03-28 置信度 0.72 AutophagyATG8Cell biologyFerritinBiology
• Single-pot, solid-phase-enhanced sample preparation for proteomics experiments
  openalex Christopher S. Hughes, Sophie Moggridge, Torsten Müller, Poul H. Sorensen 等 2018-11-16 置信度 0.72 Chaotropic agentSample preparationChromatographyProteomicsLysis
• Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network
  We demonstrate an integrated approach to build, test, and refine a model of a cellular pathway, in which perturbations to critical pathway components are analyzed using DNA microarrays, quantitative proteomics, and databases of known physical interactions. Usi…
  openalex Trey Ideker, Vésteinn Thórsson, Jeffrey A. Ranish, Rowan H. Christmas 等 2001-05-04 置信度 0.72 Computational biologyProteomicsYeastDNA microarrayBiology
• Plasma proteomic associations with genetics and health in the UK Biobank
  Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological va…
  openalex Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner 等 2023-10-04 置信度 0.72 BiobankGeneticsBiologyMedicineComputational biology
• Current two‐dimensional electrophoresis technology for proteomics
  Two-dimensional gel electrophoresis (2-DE) with immobilized pH gradients (IPGs) combined with protein identification by mass spectrometry (MS) is currently the workhorse for proteomics. In spite of promising alternative or complementary technologies (e.g. mult…
  openalex Angelika Görg, Walter Weiss, Michael J. Dünn 2004-11-15 置信度 0.72 ProteomicsChemistryChromatographyMass spectrometryIsoelectric point
• Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
  openalex Bo Shen, Xiao Yi, Yaoting Sun, Xiaojie Bi 等 2020-05-27 置信度 0.72 MetabolomicsBiologyProteomicsCoronavirus disease 2019 (COVID-19)Metabolite
• Mass spectrometry–based proteomics turns quantitative
  openalex Shao‐En Ong, Matthias Mann 2005-09-20 置信度 0.72 ProteomeMass spectrometryProteomicsQuantitative proteomicsStable isotope labeling by amino acids in cell culture
• An Automated Multidimensional Protein Identification Technology for Shotgun Proteomics
  We describe an automated method for shotgun proteomics named multidimensional protein identification technology (MudPIT), which combines multidimensional liquid chromatography with electrospray ionization tandem mass spectrometry. The multidimensional liquid c…
  openalex Dirk Wolters, Michael P. Washburn, John R. Yates 2001-10-25 置信度 0.72 ChemistryShotgun proteomicsChromatographyTandem mass spectrometryElution
• Proteomic Analysis of the Mode of Antibacterial Action of Silver Nanoparticles
  Silver nanoparticles (nano-Ag) are potent and broad-spectrum antimicrobial agents. In this study, spherical nano-Ag (average diameter = 9.3 nm) particles were synthesized using a borohydride reduction method and the mode of their antibacterial action against E…
  openalex Chun‐Nam Lok, Chi‐Ming Ho, Rong Chen, Qing‐Yu He 等 2006-03-16 置信度 0.72 Mode of actionSilver nanoparticleChemistryAntimicrobialBiophysics
• From genomics to proteomics
  openalex Mike Tyers, Matthias Mann 2003-03-01 置信度 0.72 ProteomicsGenomicsComputational biologyFunction (biology)Structural genomics
• Selected reaction monitoring for quantitative proteomics: a tutorial
  Systems biology relies on data sets in which the same group of proteins is consistently identified and precisely quantified across multiple samples, a requirement that is only partially achieved by current proteomics approaches. Selected reaction monitoring (S…
  openalex Vinzenz Lange, Paola Picotti, Bruno Domon, Ruedi Aebersold 2008-10-14 置信度 0.72 ProteomicsSelected reaction monitoringQuantitative proteomicsAnalyteNormalization (sociology)
• Proteomics: Technologies and Their Applications
  Proteomics involves the applications of technologies for the identification and quantification of overall proteins present content of a cell, tissue or an organism. It supplements the other "omics" technologies such as genomic and transcriptomics to expound the …
  openalex Bilal Aslam, Madiha Basit, Muhammad Atif Nisar, Mohsin Khurshid 等 2016-10-18 置信度 0.72 ProteomicsProteomeOrganismComputational biologyProtein expression
• Disease proteomics
  openalex Samir Hanash 2003-03-01 置信度 0.72 ProteomicsProteomeDiseaseComputational biologyComputer science
• Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics
  Proteomics is critically dependent on optimal sample preparation. Particularly, the interface between protein digestion and mass spectrometric analysis has a large influence on the overall quality and sensitivity of the analysis. We here describe a novel proce…
  openalex Juri Rappsilber, Yasushi Ishihama, Matthias Mann 2002-12-24 置信度 0.72 ChemistryChromatographySample preparationPipetteElution
• A proteomic view of the Plasmodium falciparum life cycle
  openalex Laurence Florens, Michael P. Washburn, Joshua Raine, Robert M. Anthony 等 2002-10-03 置信度 0.72 BiologyPlasmodium falciparumProteomicsGametocyteParasite hosting
• Interpretation of Shotgun Proteomic Data
  The shotgun proteomic strategy based on digesting proteins into peptides and sequencing them using tandem mass spectrometry and automated database searching has become the method of choice for identifying proteins in most large scale studies. However, the pept…
  openalex Alexey I. Nesvizhskii, Ruedi Aebersold 2005-07-11 置信度 0.72 ShotgunShotgun proteomicsComputational biologyProteomicsShotgun sequencing
• Mass Spectrometry in Proteomics
  ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass Spectrometry in ProteomicsRuedi Aebersold and David R. GoodlettView Author Information The Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, Washington 98105 Cite this: Chem. Rev. 2001, 101, 2, 269–…
  openalex Ruedi Aebersold, David R. Goodlett 2001-01-23 置信度 0.72 CitationComputer scienceInformation retrievalIdentification (biology)Icon
• Gateway‐compatible vectors for plant functional genomics and proteomics
  Gateway cloning technology facilitates high-throughput cloning of target sequences by making use of the bacteriophage lambda site-specific recombination system. Target sequences are first captured in a commercially available "entry vector" and are then recombi…
  openalex Keith Earley, Jeremy R. Haag, Olga Pontes, Kristen Opper 等 2006-01-26 置信度 0.72 BiologyComputational biologyEpitopeExpression vectorCloning (programming)
• Protter: interactive protein feature visualization and integration with experimental proteomic data
  SUMMARY: The ability to integrate and visualize experimental proteomic evidence in the context of rich protein feature annotations represents an unmet need of the proteomics community. Here we present Protter, a web-based tool that supports interactive protein…
  openalex Ulrich Omasits, Christian H. Ahrens, S. Müller, Bernd Wollscheid 2013-10-24 置信度 0.72 Computer scienceContext (archaeology)AnnotationVisualizationProteomics
• Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics
  openalex Paul J. Boersema, Reinout Raijmakers, Simone Lemeer, Shabaz Mohammed 等 2009-03-19 置信度 0.72 Stable isotope labeling by amino acids in cell cultureQuantitative proteomicsProteomicsIsobaric labelingStable isotope ratio
• Exosomes: proteomic insights and diagnostic potential
  Exosomes are 40-100-nm diameter membrane vesicles of endocytic origin that are released by most cell types upon fusion of multivesicular bodies with the plasma membrane, presumably as a vehicle for cell-free intercellular communication. While early studies foc…
  openalex Richard J. Simpson, Justin WE Lim, Robert L. Moritz, Suresh Mathivanan 2009-06-01 置信度 0.72 MicrovesiclesEndocytic cycleBiologyCell biologyProteome
• A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics
  Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas fo…
  openalex Mathias Uhlén, Erik Björling, Charlotta Agaton, Cristina Al‐Khalili Szigyarto 等 2005-08-27 置信度 0.72 Human Protein AtlasHuman proteome projectProteomicsProteomeComputational biology
• Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
  openalex Sung Chan Kim, Robert W. Sprung, Yue Chen, Yingda Xu 等 2006-08-01 置信度 0.72 BiologyAcetylationLysineProteomicsChromatin
• Protein microarrays and proteomics
  openalex Gavin MacBeath 2002-11-26 置信度 0.72 BiologyProteomicsComputational biologyDNA microarrayProtein microarray
• Protein Analysis by Shotgun/Bottom-up Proteomics
  ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTProtein Analysis by Shotgun/Bottom-up ProteomicsYaoyang Zhang†, Bryan R. Fonslow†, Bing Shan†, Moon-Chang Baek†‡, and John R. Yates, III*†View Author Information† Department of Chemical Physiology, The Scripps Researc…
  openalex Yaoyang Zhang, Bryan R. Fonslow, Bing Shan, Moon‐Chang Baek 等 2013-02-26 置信度 0.72 CitationLibrary sciencePhoneShotgun proteomicsComputer science
• ViPTree: the viral proteomic tree server
  SUMMARY: ViPTree is a web server provided through GenomeNet to generate viral proteomic trees for classification of viruses based on genome-wide similarities. Users can upload viral genomes sequenced either by genomics or metagenomics. ViPTree generates proteo…
  openalex Yosuke Nishimura, Takashi Yoshida, Megumi Kuronishi, Hideya Uehara 等 2017-03-21 置信度 0.72 GenomeUploadComputational biologyMetagenomicsBiology
• Proteomic characterization of the human centrosome by protein correlation profiling
  openalex Jens Andersen, Christopher J. Wilkinson, Thibault Mayor, Peter Mortensen 等 2003-12-01 置信度 0.72 CentrosomeCell biologyMicrotubuleBiologyMitosis
• Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells
  openalex Nils A. Kulak, Garwin Pichler, Igor Paron, Nagarjuna Nagaraj 等 2014-02-02 置信度 0.72 ProteomeLysisProteomicsSample preparationElution
• Directed Proteomic Analysis of the Human Nucleolus
  openalex Jens Andersen, Carol E. Lyon, Archa H. Fox, Anthony K. L. Leung 等 2002-01-01 置信度 0.72 BiologyNucleolusComputational biologyProteomicsCell biology
• Proteomics by Mass Spectrometry: Approaches, Advances, and Applications
  Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale proteomics. In this review, we dissect the overall framework of the MS experiment into its key components. We discuss the fundamentals of proteomic analyses as well as recent de…
  openalex John R. Yates, Cristian Ruse, Aleksey Nakorchevsky 2009-07-10 置信度 0.72 OrbitrapPhosphoproteomicsMass spectrometryProteomicsPhosphopeptide
• Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging
  Microscopy and mass spectrometry (MS) are complementary techniques: The former provides spatiotemporal information in living cells, but only for a handful of recombinant proteins at a time, whereas the latter can detect thousands of endogenous proteins simulta…
  openalex Jeffrey D. Martell, Alice Y. Ting, Hyun‐Woo Rhee, Peng Zou 等 2012-09-01 置信度 0.72 OrganelleMitochondrionProteomicsComputational biologyBiology
• A proteomic atlas of senescence-associated secretomes for aging biomarker development
  The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few doz…
  openalex Nathan Basisty, Abhijit Kale, Ok Hee Jeon, Chisaka Kuehnemann 等 2020-01-16 置信度 0.72 BiologySenescencePhenotypeNeurodegenerationBiomarker
• Functional and quantitative proteomics using SILAC
  openalex Matthias Mann 2006-12-01 置信度 0.72 Stable isotope labeling by amino acids in cell culturePhosphoproteomicsQuantitative proteomicsProteomicsProteome
• Mass spectrometry for proteomics
  openalex Xuemei Han, Aaron Aslanian, John R. Yates 2008-08-20 置信度 0.72 Mass spectrometryProteomicsOrbitrapElectron-transfer dissociationProteome
• DTASelect and Contrast:  Tools for Assembling and Comparing Protein Identifications from Shotgun Proteomics
  The components of complex peptide mixtures can be separated by liquid chromatography, fragmented by tandem mass spectrometry, and identified by the SEQUEST algorithm. Inferring a mixture's source proteins requires that the identified peptides be reassociated. …
  openalex David L. Tabb, W. Hayes McDonald, John R. Yates 2002-01-07 置信度 0.72 Shotgun proteomicsProteomicsTandem mass spectrometryComputer scienceShotgun
• Revisiting biomarker discovery by plasma proteomics
  Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and …
  openalex Philipp E. Geyer, Lesca M. Holdt, Daniel Teupser, Matthias Mann 2017-09-01 置信度 0.72 ProteomeProteomicsBiomarker discoveryComputational biologyBiomarker
• Proteomic applications for the early detection of cancer
  openalex Julia Wulfkuhle, Lance A. Liotta, Emanuel F. Petricoin 2003-04-01 置信度 0.72 CancerCarcinogenesisDiseaseStage (stratigraphy)Cancer biomarkers
• Heavy Metal Tolerance in Plants: Role of Transcriptomics, Proteomics, Metabolomics, and Ionomics
  Heavy metal contamination of soil and water causing toxicity/stress has become one important constraint to crop productivity and quality. This situation has further worsened by the increasing population growth and inherent food demand. It has been reported in …
  openalex Samiksha Singh, Parul Parihar, Rachana Singh, Vijay Pratap Singh 等 2016-02-08 置信度 0.72 MetabolomicsProteomicsCrop productivityBiologyMetal toxicity
• Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
  Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of pro…
  openalex Benjamin F. Cravatt, Aaron Wright, John W. Kozarich 2008-03-26 置信度 0.72 ProteomicsComputational biologyChemistryProfiling (computer programming)Protein chemistry
• Exponentially Modified Protein Abundance Index (emPAI) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides per Protein
  To estimate absolute protein contents in complex mixtures, we previously defined a protein abundance index (PAI) as the number of observed peptides divided by the number of observable peptides per protein (Rappsilber, J., Ryder, U., Lamond, A. I., and Mann, M.…
  openalex Yasushi Ishihama, Yoshiya Oda, Tsuyoshi Tabata, Toshitaka Sato 等 2005-06-15 置信度 0.72 ProteomicsLysisChemistryQuantitative proteomicsMolecular biology
• Proteomic analysis of a eukaryotic cilium
  Cilia and flagella are widespread cell organelles that have been highly conserved throughout evolution and play important roles in motility, sensory perception, and the life cycles of eukaryotes ranging from protists to humans. Despite the ubiquity and importa…
  openalex Gregory J. Pazour, Nathan S. Agrin, John Leszyk, George B. Witman 2005-07-04 置信度 0.72 FlagellumBiologyCiliumChlamydomonas reinhardtiiProteome
• Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics
  Selected reaction monitoring on a triple quadrupole mass spectrometer is currently experiencing a renaissance within the proteomics community for its, as yet, unparalleled ability to characterize and quantify a set of proteins reproducibly, completely, and wit…
  openalex Amelia C. Peterson, Jason D. Russell, Derek J. Bailey, Michael S. Westphall 等 2012-08-03 置信度 0.72 ProteomicsHigh resolutionSelected reaction monitoringQuantitative proteomicsComputational biology
• iProX in 2021: connecting proteomics data sharing with big data
  The rapid development of proteomics studies has resulted in large volumes of experimental data. The emergence of big data platform provides the opportunity to handle these large amounts of data. The integrated proteome resource, iProX (https://www.iprox.cn), w…
  openalex Tao Chen, Jie Ma, Yi Liu, Zhiguang Chen 等 2021-10-22 置信度 0.72 ScalabilityComputer scienceProteomicsBig dataProteome
• Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions
  openalex Paola Picotti, Ruedi Aebersold 2012-05-30 置信度 0.72 ProteomicsWorkflowShotgun proteomicsComputer scienceComputational biology
• Proteomics: quantitative and physical mapping of cellular proteins
  openalex Walter Blackstock, Malcolm Weir 1999-03-01 置信度 0.72 ProteomicsProteomeBiologyComputational biologyGenome
• Proteomic analysis of NMDA receptor–adhesion protein signaling complexes
  openalex Holger Husi, Malcolm Ward, Jyoti S. Choudhary, Walter Blackstock 等 2000-07-01 置信度 0.72 NMDA receptorNeuroscienceNeuroscientistReceptorSignal transduction
• A guided tour of the Trans‐Proteomic Pipeline
  The Trans-Proteomic Pipeline (TPP) is a suite of software tools for the analysis of MS/MS data sets. The tools encompass most of the steps in a proteomic data analysis workflow in a single, integrated software system. Specifically, the TPP supports all steps f…
  openalex Eric W. Deutsch, Luis Mendoza, David Shteynberg, Terry Farrah 等 2010-01-25 置信度 0.72 Pipeline (software)WorkflowComputer scienceSuiteSoftware
• The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices
  The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing both biophysical and biochemical cues that are important regulators of cell proliferation, survival, differentiation, and migration. We present here a proteomic strategy de…
  openalex Alexandra Naba, Karl R. Clauser, Sebastian Hoersch, Hui Liu 等 2011-12-09 置信度 0.72 In silicoProteomicsIn vivoComputational biologyBiology
• Proteomics: the first decade and beyond
  openalex Scott D. Patterson, Ruedi H. Aebersold 2003-02-27 置信度 0.72 ProteomicsBiologyComputational biologyScope (computer science)Proteome
• Large-Scale Proteomic Analysis of the Human Spliceosome
  In a previous proteomic study of the human spliceosome, we identified 42 spliceosome-associated factors, including 19 novel ones. Using enhanced mass spectrometric tools and improved databases, we now report identification of 311 proteins that copurify with sp…
  openalex Juri Rappsilber, Ursula Ryder, Angus I. Lamond, Matthias Mann 2002-07-19 置信度 0.72 SpliceosomeRNA splicingBiologyAlternative splicingComputational biology
• Intrinsic Disorder and Functional Proteomics
  openalex Predrag Radivojac, Lilia M. Iakoucheva, Christopher J. Oldfield, Zoran Obradović 等 2006-12-08 置信度 0.72 ProteomicsComputational biologyIntrinsically disordered proteinsProtein functionFunction (biology)
• MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics
  openalex Lily Ting, Ramin Rad, Steven P. Gygi, Wilhelm Haas 2011-10-02 置信度 0.72 Isobaric processIsobaric labelingMass spectrometryProteomeQuantitative proteomics
• Molecular Biologist's Guide to Proteomics
  The emergence of proteomics, the large-scale analysis of proteins, has been inspired by the realization that the final product of a gene is inherently more complex and closer to function than the gene itself. Shortfalls in the ability of bioinformatics to pred…
  openalex Paul R. Graves, Timothy Haystead 2002-03-01 置信度 0.72 ProteomicsProteomeBiologyComputational biologyFunction (biology)
• Proteomic analysis of the mammalian nuclear pore complex
  As the sole site of nucleocytoplasmic transport, the nuclear pore complex (NPC) has a vital cellular role. Nonetheless, much remains to be learned about many fundamental aspects of NPC function. To further understand the structure and function of the mammalian…
  openalex Janet M. Cronshaw, Andrew N. Krutchinsky, Wenzhu Zhang, Brian T. Chait 等 2002-08-26 置信度 0.72 NucleoporinNuclear poreBiologyProteomeHuman proteome project
• Proteomic profiling of exosomes: Current perspectives
  Exosomes are 40-100 nm membrane vesicles of endocytic origin secreted by most cell types in vitro. Recent studies have shown that exosomes are also found in vivo in body fluids such as blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage flu…
  openalex Richard J. Simpson, Søren Skov Jensen, Justin Lim 2008-09-05 置信度 0.72 MicrovesiclesEndocytic cycleCell biologyExosomeBiology
• GoMiner: a resource for biological interpretation of genomic and proteomic data
  We have developed GoMiner, a program package that organizes lists of 'interesting' genes (for example, under- and overexpressed genes from a microarray experiment) for biological interpretation in the context of the Gene Ontology. GoMiner provides quantitative…
  openalex Barry R. Zeebèrg, Weimin Feng, Geoffrey Wang, May D. Wang 等 2003-04-01 置信度 0.72 BiologyDirected acyclic graphComputational biologyGene ontologyInterpretation (philosophy)
• The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics
  Skyline is a freely available, open-source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors. This review covers the informatics enco…
  openalex Lindsay K. Pino, Brian C. Searle, James G. Bollinger, Brook L. Nunn 等 2017-07-09 置信度 0.72 SkylineProteomicsChemistryMass spectrometryHealth informatics tools
• Proteomics: the move to mixtures
  Proteomics can be defined as the systematic analysis of proteins for their identity, quantity and function. In contrast to a cell's static genome, the proteome is both complex and dynamic. Proteome analysis is most commonly accomplished by the combination of t…
  openalex Junmin Peng, Steven P. Gygi 2001-10-01 置信度 0.72 ChemistryProteomeProteomicsTandem mass spectrometryMass spectrometry