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• Unveiling the aging-immune axis in irritable bowel syndrome: a multi-omics and machine learning approach to biomarker discovery and validation.
  Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with an elusive pathophysiology. Although immune dysregulation and mild mucosal inflammation are recognized as important factors in IBS, the specific contribution of immunosenes…
  pubmed Yao Y, Li J, Zhang B, Li T 等 2026 置信度 0.82
• Splenectomy revisited in Wiskott-Aldrich syndrome in the era of HSCT and gene therapy: a bridge, a rescue, or simply obsolete?
  Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by mutations in the WAS gene, classically presenting with microthrombocytopenia, eczema, and recurrent infections, with an incidence of approximately 1 per 100, 000 live births. …
  pubmed Khanafer Y, Al-Naemi A, Khayyat L, Cyprian F 2026 置信度 0.82
• Development of a proposed guide to identify, screen and appraise self-report and device-based measures of habitual physical activity in systematic reviews: a methodological protocol.
  Habitual physical activity (PA) is a fundamental determinant of health, yet its assessment and reporting vary substantially across research studies, creating persistent challenges for evidence synthesis. Systematic reviews that aim to synthesise habitual PA ou…
  pubmed Dall P, Skelton DA, Abaraogu U 2026 置信度 0.82
• Tumor fat composition predicts response to everolimus and supports low-dose therapy in TSC-associated renal angiomyolipomas: a multicenter prospective study.
  Renal angiomyolipomas associated with tuberous sclerosis complex (TSC-RAML) may lead to progressive renal damage and hemorrhage. Everolimus is recommended as first-line therapy, but predictors of treatment response and optimal dosing strategies remain unclear.…
  pubmed Gao K, Duan Y, Ren B, Guo B 等 2026 置信度 0.82
• Case Report: Zero-contrast multivessel PCI with left main bifurcation guided by dual IVUS strategies using a coronary CTA roadmap.
  Zero-contrast percutaneous coronary intervention (PCI) has emerged as an alternative strategy for patients with contraindications to iodinated contrast media. Nevertheless, the majority of reported cases depend on prior invasive coronary angiography for proced…
  pubmed Hu T, Huang M, Huang L 2026 置信度 0.82
• National guidelines and good practices on unmet needs in self-care, education, training, and digital tools in person-centered dementia care models across Europe-a cross-country comparative analysis.
  People with dementia and their caregivers regularly face unmet needs, not only in dementia care, but also in self-care, education, training, and the use of digital tools. National dementia policies, clinical guidelines, and best practices can improve dementia …
  pubmed Blecha N, Johannsen AH, Kuźma-Kozakiewicz M, Cwiek P 等 2026 置信度 0.82
• Profiles of sleep disturbances in Angelman, Prader-Willi, and Rett syndromes: analysis of standardized questionnaires.
  Individuals with neurodevelopmental disorders (NDDs) are at increased risk of having sleep difficulties. A variety of sleep problems have been reported in Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Rett syndrome (RTT). The present study intended …
  pubmed Oberman LM, Veatch OJ, Peters SU, Kaufmann WE 2026 置信度 0.82
• The Role of Virtual Reality in Chronic Pain and Loneliness: Narrative Review.
  Chronic pain and loneliness are significant public health challenges that often intersect, leading to a cyclical cycle of physical, emotional, and social distress. The COVID-19 pandemic has further exacerbated these issues, highlighting the need for innovative…
  pubmed Pan A, Moreau S, Rafeeh G, Ahsan N 等 2025 置信度 0.82
• Comparison of Social Frailty and Oral Health Literacy Among Older Adults in Urban and Rural Areas: A Cross-Sectional Study.
  Social frailty and oral health literacy (OHL) may be influenced by the residential environment; however, evidence regarding regional differences among older adults remains limited. This study aimed to examine differences in social frailty and OHL between older…
  pubmed Ichinomiya M, Shirayama Y, Fujiwara S, Kitamura M 等 2026 置信度 0.82
• Harnessing genomics for fast development and commercial introduction of high-resistant tomato varieties to Tomato Brown Rugose Fruit Virus.
  Tomato plants are susceptible to a wide range of viruses, including those belonging to the genus Tobamovirus , which pose enormous threats to tomato cultivation worldwide. This article reviews a genomics-based breeding strategy applied for the rapid discovery …
  pubmed Verweij W, de la Fuente van Bentem S, Ykema M, Perefarres F 等 2026 Mar 置信度 0.82
• Early-life phthalate mixture exposure and reproductive hormone levels during minipuberty.
  Phthalates (PAEs) are ubiquitous endocrine-disrupting chemicals (EDCs) with well-documented prenatal effects, while their impact during early postnatal life remains less understood. Minipuberty, a transient activation of the hypothalamic-pituitary-gonadal (HPG…
  pubmed Trevisani V, Lucaccioni L, Starace F, Passini E 等 2026 置信度 0.82
• Connexin50 hemichannels are opened by CO(2): implications for lens physiology.
  Connexin50 (Cx50) is expressed in lens fiber cells. As mutations in Cx50 cause cataracts, its physiological role in the lens must be important. We have used recent cryo-EM structures of Cx50 and the predictive power of Alphafold3 to identify the presence of a …
  pubmed Lovatt A, Bibra F, Wijayapala A, Mui M 等 2026 置信度 0.82
• Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury.
  Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide, yet the associations linking alcohol-induced gut microbial alterations to metabolic remodeling and hepatocyte dysfunction remain incompletely understood. H…
  pubmed Ding R, Qi F, Dai Q, Li K 等 2026 置信度 0.82
• Reporting Guideline for Therapeutic Immersive Virtual Reality Interventions: International eDelphi Study (INVIRTUE).
  With the rising adoption of virtual reality (VR) in health care, research publications on the topic are increasing rapidly. Guidance on reporting VR interventions is limited, which risks misinterpretation of findings, inappropriate data synthesis in reviews an…
  pubmed Slatman S, Harvie D, van der Heijden M, Bulle L 等 2025 置信度 0.82
• Recent progress in DNA marker-assisted selection for vegetable breeding in Japan.
  The development of new cultivars exhibiting high levels of disease resistance and superior quality is critical for vegetable production. Recent advances in genomics and DNA sequencing technologies have facilitated the identification of sequence variants associ…
  pubmed Nunome T, Kawasaki M, Kakizaki T, Miyatake K 等 2026 Mar 置信度 0.82
• An anaphylactic reaction without skin manifestations after general anesthesia induction: a case report.
  Anaphylaxis is a severe, potentially life-threatening hypersensitivity reaction. Although anaphylaxis rarely occurs during dental anesthesia, preparation for a prompt and appropriate response is crucial. Severe anaphylaxis may occur in the absence of typical s…
  pubmed Suyama M, Yoshida M, Imamura S, Oda A 等 2026 Aug 置信度 0.82
• Reporting on the Acceptance and Usability of a Virtual Reality Visual Rehabilitation Program in Pediatric Patients With Homonymous Hemianopia.
  Visual field defects are common in patients with brain tumors. In children, early vision loss can lead to delayed development of motor, language, and social skills, limiting their independence and increasing the risk of depression or anxiety later in life. The…
  pubmed Tchao D, Garcia-Giler E, Cheung K, Zhang B 等 2024 置信度 0.82
• An Open-Source, Reproducible MRI Data Acquisition and Reconstruction Workflow Using Pulseq: Multi-Site and Cross-Vendor Validation.
  Reproducibility in MRI is limited by variability in data acquisition, formatting, and reconstruction across sites and vendors. This work aimed to mitigate these challenges through an open-source, vendor-independent workflow originally developed for the 2023-24…
  pubmed Chen Q, Roos THM, Murguia A, Xie Y 等 2026 Aug 6 置信度 0.82
• Evaluating the presentation of fatigue and apathy, their predictors, and their association with quality of life (QoL), among stroke survivors: An Australian cross-sectional study.
  This cross-sectional study: (1) investigated the presentation (frequency and severity) of fatigue and apathy after stroke; (2) identified predictors of post-stroke fatigue and apathy; and (3) explored the association between the presentation of fatigue and apa…
  pubmed Bajorek B, Bivard A, Lim L, Lillicrap T 等 2026 Aug 6 置信度 0.82
• Blue light therapy delivered through light glasses improves sleep quality and daytime sleepiness in Parkinson's disease: A randomized trial.
  BackgroundSleep disturbances, including excessive daytime sleepiness (EDS) and fragmented nocturnal sleep, are common in Parkinson's disease (PD) and significantly reduce quality of life. This pilot study evaluated the efficacy of a novel approach using blue l…
  pubmed Śmiłowska K, de Vries NM, Bloem BR, van Wamelen DJ 2026 Aug 6 置信度 0.82
• An analysis of AI platforms: Can AI provide genetics education?
  With the introduction, free access, and proliferation of various artificial intelligence (AI) in unique platforms, patients have access to more summarized information than ever. Our study aimed to explore the use of AI chatbots to improve patients' understandi…
  pubmed Shin A, Shin R, Ramirez M, Bondre IL 等 2026 Aug 置信度 0.82
• Insights Into Divergent Mechanisms of Pyrite Oxidation by Indigenous Fungi From Mine Tailings.
  Fungi can oxidise pyrite, a process which has potential implications for metal bioleaching and acid mine drainage formation. However, this capacity has been demonstrated primarily using only a few model fungal strains. Diverse fungal communities are known to i…
  pubmed Li YX, Li YY, Luo XL, Wu GX 等 2026 Aug 置信度 0.82
• Developing an Educational Visual Tool to Support Families Considering Whole-Exome Sequencing in Japan.
  Whole-exome sequencing (WES) is increasingly used in pediatric diagnostics, yet families often struggle to understand its complexity and implications. Educational resources that facilitate informed decision-making are essential in genomic medicine. This study …
  pubmed Harada K, Kaneko M, Kosugi S, Kawame H 2026 Jan-Dec 置信度 0.82
• Genomic Benchmarking Reveals Reduced and Context-Dependent Transferability of AI-Engineered Bxb1 Recombinases for Large-Fragment Genome Writing.
  Programmable large-fragment genome integration using prime-editing-coupled serine integrases, such as PASTE and PASSIGE, remains constrained by the limited activity of wild-type Bxb1 (WT Bxb1) in mammalian cells. Recently, the AI-guided protein engineering fra…
  pubmed Sun YD, Song LJ, Liu B, Cheng CY 等 2026 Aug 6 置信度 0.82
• Sex specificity of resistance to caTAUstrophe.
  As amyloid beta (Aβ) accumulates, tau pathology spreads beyond medial temporal lobe (MTL) into neocortical (NEO) regions, though some older adults resist this progression, or what we call here "caTAUstrophe." Given previous evidence of higher tau levels …
  pubmed Carrigan M, Birkenbihl C, Klinger HM, Langford O 等 2026 Aug 置信度 0.82
• In-Vitro Evaluation of HIV/SARS-CoV-2 Co-Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders.
  Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood-brain barrier (BBB) disruptio…
  pubmed Acharya A, Thurman M, Sutar D, Olasunkanmi OI 等 2026 Aug 置信度 0.82
• Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice.
  Adipose tissue remodelling, encompassing white adipose tissue (WAT) browning alongside brown adipose tissue (BAT) activation, holds promise for combating obesity, yet the endogenous chemokine receptors that restrain this plasticity remain ill-defined. Here, we…
  pubmed Cai S, Ma M, Zhu Y, Shi M 等 2026 Aug 置信度 0.82
• Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption.
  Hyperuricemia (HUA) is a common metabolic disorder with limited safe and effective therapeutic options. This study integrated GEO dataset mining and network pharmacology to explore the anti-HUA efficacy and mechanism of pomegranate peel polyphenol extract (PPE…
  pubmed Yin Z, Liang S, Yang G, Guo P 等 2026 Aug 置信度 0.82
• Strain-Specific DSE Effects on Yam Rhizosphere Carbon Metabolism Are Modulated by Soil Factors.
  Rhizosphere microbes are vital for plant growth. Dark septate endophytes (DSE) can enhance host plant adaptability and regulate microbial communities, showing promise for yam soil remediation. This study examined how single and mixed inoculations of eight DSE …
  pubmed Guo J, Su Z, Zhou M, Zuo Y 等 2026 Aug 置信度 0.82
• Promoter-Level Regulation of Melatonin Biosynthesis in Plant Stress Responses: A Framework for Climate-Resilient Crop Improvement.
  Climate change increasingly exposes crops to overlapping abiotic and biotic stresses, creating a need for regulatory strategies that improve stress tolerance without imposing unnecessary fitness costs under favorable conditions. Melatonin has been widely assoc…
  pubmed Khan MHU, Muhammad A, Li L, Zhang D 等 2026 Sep 置信度 0.82
• From Familiar Faces to New Spaces: Perceived Social Network Change and Its Association With Loneliness During the Transition to University.
  Loneliness among young people is a growing concern, and life transitions can create significant upheaval in social networks. The scale of these changes and their association with loneliness remains underexplored.
  pubmed Slack HR, Byrom N, Bate C, Hościłowicz A 等 2026 Aug 6 置信度 0.82
• Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism.
  Visual processing undergoes rapid development in the first year of life, supporting the emergence of higher-order cognitive, language, and motor functions. Visual evoked potentials (VEPs) provide a noninvasive measure of visual system maturation that may shed …
  pubmed Dickinson A, Booth M, Huberty S, Ryan D 等 2026 Sep 置信度 0.82
• Integrative Bioinformatics Approaches in Environmental Biotechnology: A Review.
  Environmental biotechnology increasingly relies on bioinformatics to address global challenges in pollution control or degradation, biodiversity conservation, and sustainable resource management. By integrating genomics, computational tools, and artificial int…
  pubmed Teklay YT 2026 置信度 0.82
• scLncR: An Integrated and Flexible Pipeline for lncRNA Analysis in Single-Cell RNA Sequencing Data.
  Long non-coding RNAs (lncRNAs) are important regulators of cellular processes, but their analysis at single-cell resolution remains challenging because lncRNA prediction, quantification, cell-type-specific characterization and downstream functional interpretat…
  pubmed Yin S, Lu Y, Yan W, Zhu Z 等 2026 Aug 6 置信度 0.82
• Defining the underlying pathology of corticobasal syndrome using clinical features and biomarkers.
  Corticobasal degeneration (CBD) is a late onset progressive neurodegenerative condition of the 4-repeat-tauopathy-type, classically presenting with asymmetrical rigidity, dystonia and myoclonus. In the most recent diagnostic criteria, Armstrong and colleagues …
  pubmed Vaughan DP, Jensen MT, Real R, Fumi RG 等 2026 Aug 6 置信度 0.82
• Age-Specific Monte Carlo Simulation-Based Microbial Risk Assessment of Drinking Water Contamination in Islamabad: Integrating Hydrochemical Analysis.
  Microbial contamination of drinking water poses a significant public health concern, yet age-specific risks in Islamabad, Pakistan, remain poorly characterized. This study applied a Monte Carlo simulation-based quantitative microbial risk assessment to estimat…
  pubmed Haider Z, Ali W, Mahmood S, Khalid A 2026 Aug 置信度 0.82
• Distribution and Chemical Nature of Al(2)O(3) Residues Following the Sandblasting Process: An In Vitro Study Using SEM, EDS, and Cytotoxicity Analysis.
  Osseointegration is a fundamental requirement for the long-term success of dental implants. Several implant systems have demonstrated excellent clinical outcomes over time, confirming their high reliability in the treatment of edentulism, even in patients with…
  pubmed Scarano A, Gehrke SA, Falisi G, Tari SR 等 2026 置信度 0.82
• RNA cytidine acetylation in archaea.
  pubmed Wang JT, Zhou XL 2026 Jul 28 置信度 0.82
• Synthesis of Pollinator-Friendly Management in European Protected Areas.
  Pollinators are important to humans and nature due to their role in ecosystem functioning and services. Research on the effects of pollinator management in protected areas is insufficient compared with that on farmlands and urban areas, potentially hindering a…
  pubmed Süle G, Báldi A, Kleijn D, Steffan-Dewenter I 等 2026 Aug 5 置信度 0.82
• Comparison of Synchronous Telerehabilitation and Face-to-Face Methods on Upper Extremity Function in Children with Hemiparetic Cerebral Palsy.
  This study investigates whether synchronous telerehabilitation improves upper extremity function in children with hemiparetic cerebral palsy (CP).
  pubmed Altun GP, Zengin Alpözgen A 2026 Aug 5 置信度 0.82
• Northern Light Reviews - Rethinking Plant Stress Biology in a Multifactorial World.
  The accelerated pace of climate change, soil degradation, environmental pollution, and pathogen outbreaks subjects trees and crops growing in different parts of the world to multiple abiotic/biotic stress conditions, simultaneously or sequentially. Unfortunate…
  pubmed Pascual LS, Rivero RM, Zandalinas SI, Mittler R 2026 Jul-Aug 置信度 0.82
• Protective Effects of Donkey Milk-Derived Exosomes Against UVB-Induced Skin Photoaging via Regulation of DNA Damage and Aging-Related Pathways.
  Prolonged exposure to UVB radiation accelerates skin photoaging by inducing DNA damage, promoting collagen degradation, and triggering cellular senescence. There is a growing interest in identifying effective natural interventions to prevent or mitigate these …
  pubmed Yu J, Sun J, Cheng J, Liu G 等 2026 置信度 0.82
• Rapid phospholipid flipping protects rice plasma membrane from heat stress.
  pubmed Chen T, Han Y, Ding Y 2026 Aug 5 置信度 0.82
• Computed Tomography and Plasma Proteomics for Early Discrimination of Post-Pancreatitis Diabetes Mellitus.
  BACKGROUND There is a lack of effective predictive methods for post-pancreatitis diabetes mellitus (PPDM-A) in clinical practice. This exploratory study aimed to identify candidate computed tomography (CT) and plasma proteomic features associated with subseque…
  pubmed Hu R, Zeng X, Li G, Ma J 等 2026 Aug 6 置信度 0.82
• Can plant-soil feedbacks scale up from individual species to communities: tests of the richness and biomass-ratio hypotheses.
  Plant-soil feedbacks (PSFs) play an important role in maintaining biodiversity and ecosystem functioning. In nature, multiple plant species collectively shape soil biotic and abiotic properties, thereby influencing subsequent plants (hereafter: community-level…
  pubmed Li M, Sun Y, Siemann E, Kardol P 等 2026 Aug 5 置信度 0.82
• Predatory ladybirds avoid ant cuticular undecane, reducing predation and oviposition.
  The ladybird Harmonia axyridis is an important predatory natural enemy, and during both predation and oviposition it encounters interference from the black garden ant Lasius niger, as ants aggressively defend aphid colonies and thereby restrict ladybirds' acce…
  pubmed Duan Y, Li X, Zhang S, Jiao X 等 2026 Aug 5 置信度 0.82
• Conformational determinants of glucagon stability and aggregation kinetics in aqueous and commercial formulations.
  Glucagon is a well-established therapeutic peptide, widely used to treat hypoglycemia. Like many peptide drugs, it offers advantages such as specificity, biocompatibility, and high affinity for receptor targets, but suffers from limited physical and chemical s…
  pubmed Santoro A, Macis M, Buonocore M, Ricci A 等 2026 Sep 置信度 0.82
• Multicomponent Peptide-MXene-Hyaluronic Acid Hydrogel as a Conductive Scaffold for Enhanced Fibroblast Proliferation and Migration Under Electrical Stimulation.
  Chronic and acute skin wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, reduced cell proliferation and migration, and a high risk of infection. These pathological conditions highlight the need for advanced biomate…
  pubmed Loboda O, Cohen-Gerassi D, Goldstein DA, Messer O 等 2026 Aug 5 置信度 0.82
• Behavioral Phenotyping of the Pah(enu2) Mouse Model for Phenylketonuria-A Scoping Review and Future Perspectives.
  Phenylketonuria (PKU) is a rare metabolic disorder resulting from a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), resulting in very high phenylalanine (Phe) levels in blood and brain. A PKU mutant mouse model was developed via N-eth…
  pubmed Cao J, Kruizinga L, Hovens IB, van der Goot E 等 2026 Sep 置信度 0.82
• Vision, hearing, and dementia in older adults receiving home care services: implications for optometric practice.
  Vision and hearing impairments are common in older adults and are often comorbid with dementia. These conditions exacerbate the impact of dementia, and outcomes for those with dual sensory impairment are considerably worse than for people with single sensory i…
  pubmed Toomey M, Gurteen H, Franco B, Piano M 等 2026 Aug 5 置信度 0.82
• 'You know you're going to get through this': Volunteers and long-term disaster recovery.
  As nature-induced disasters intensify and reliance on volunteer support grows, volunteers are now increasingly critical to disaster response and recovery, particularly in countries like Australia. This paper advances our empirical understanding of volunteer co…
  pubmed Sharma N, Kuskoff E, Parsell C 2026 Oct 置信度 0.82
• Development of Membrane Transport-Inspired Biomimetic System to Degrade Plasticizers.
  Plasticizers added to plastics are toxic, endocrine-disrupting chemicals that may leach into the environment. Chemical and microbial degradation were reported to degrade the plasticizers. Most chemical methods operate at high temperature and pressure (energy-i…
  pubmed Mandal R, Sar S, Maiti T, Hazra B 等 2026 Aug 置信度 0.82
• Thyroid Hormone-Induced Metabolic Stress Unmasking Latent Wernicke Encephalopathy.
  pubmed Abdul-Aziz O, Lughmani M, Altorok I, Assaly A 等 2026 Aug 6 置信度 0.82
• A decoupled alignment kernel for peptide membrane permeability predictions.
  Cyclic peptides are promising modalities for targeting intracellular sites; however, cell-membrane permeability remains a key bottleneck, exacerbated by limited public data and the need for well-calibrated uncertainty. Instead of relying on data-eager complex …
  pubmed Amirahmadi A, Geylan G, De Maria L, Etminani F 等 2026 Aug 4 置信度 0.82
• Understanding zoonotic spillover interfaces for the design of a One Health education intervention: a qualitative baseline study from rural Thailand.
  Prevention of zoonotic spillover requires an understanding of how human, animal, and environmental interactions shape risk in everyday life. Efforts have focused largely on surveillance and response rather than on primary prevention informed by lived experienc…
  pubmed Bärnighausen K, Phongsiri M, Lilier K, Tomklang S 等 2026 Aug 4 置信度 0.82
• Clifti-GPT: privacy-preserving federated fine-tuning and transferable inference of foundation models on clinical single-cell data.
  Foundation models have demonstrated immense value for scRNA-seq analysis, but their fine-tuning or inference on heterogeneous, privacy-sensitive clinical cohorts is governed by strict data protection policies, which often prohibit centralization. We introduce …
  pubmed Bakhtiari M, Elkjaer ML, Can AO, Theis F 等 2026 Aug 5 置信度 0.82
• Mitochondrial Mechanisms in the Potential Male Reproductive Toxicity of E-Cigarette-Derived Metal-Containing Nanoparticles.
  E-cigarette devices emit ultrafine metal-containing particles from heating coils, solder joints, and other wetted components, but their reproductive toxicology remains poorly defined. This review integrates evidence from aerosol chemistry, nanoparticle toxicol…
  pubmed Sailis AB 2026 Aug 5 置信度 0.82
• Long-term associations between seasonal variability and malaria transmission in Bangladesh: a 16-year national time-series analysis.
  Malaria transmission is strongly influenced by climatic conditions that regulate Anopheles mosquito survival and parasite development. However, existing studies in Bangladesh are largely short-term or region-specific, limiting understanding of long-term climat…
  pubmed Akter S, Ahmed Z, Abid R, Asha MM 等 2026 Aug 4 置信度 0.82
• TOP 2025: An update to the Transparency and Openness Promotion Guidelines.
  Transparency and openness are core scientific values that enable independent verification of reported research results. The Transparency and Openness Promotion (TOP) Guidelines, first published in 2015 (TOP 2015), provided a flexible framework for journals to …
  pubmed Grant S, Corker KS, Mellor D, Stewart SLK 等 2026 Aug 5 置信度 0.82
• Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics.
  Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigatio…
  pubmed Zhang D, Ding Y, Kang W, Zhu X 等 2026 Aug 5 置信度 0.82
• Asthma-related mortality in Italian children and adolescents.
  Despite the progress made in the last few decades in diagnosis and therapy, children and adolescents still die of asthma worldwide. In this study, we collected all asthma-related death events in Italian children and adolescents (0-19 years old) from 2013 to 20…
  pubmed Saretta F, Giovannini M, Klain A, Pecoraro L 等 2026 Aug 5 置信度 0.82
• Nasogastric tube as an improvised chest drain for tension pneumothorax in a resource-limited rural clinic: bridging a 4-hour transfer time in the absence of a standard intercostal drain.
  Tension pneumothorax is a life-threatening emergency requiring immediate decompression followed by definitive pleural drainage to prevent rapid cardiopulmonary collapse. Management becomes particularly challenging in resource-limited settings where standard in…
  pubmed Rinzin U, Rinzin C, LeVine S 2026 Aug 5 置信度 0.82
• Genomic characteristics and geographical distribution of uncultivated soil prokaryotes.
  Most soil prokaryotic species remain uncultivated, limiting our understanding of the terrestrial microbiome. Metagenomic sequencing, and particularly the study of metagenome-assembled genomes (MAGs), represents an unprecedented opportunity to characterize the …
  pubmed Rodríguez Del Río Á, Cui Y, Mansour I, Rillig MC 2026 Aug 4 置信度 0.82
• Urban green roofs host intrinsic resistomes shaped by management but not dominated by pathogenic resistance.
  Urban green roofs are increasingly introduced to enhance urban biodiversity and ecosystem services, yet their role in shaping antimicrobial resistance in cities remains unclear. Using long-read metagenomic sequencing, we characterized antimicrobial resistance …
  pubmed Martínez-Cuesta R, Craighero A, Walch S, Helmreich B 等 2026 Aug 6 置信度 0.82
• Systematic prioritization of candidate genes in camptothecin biosynthesis using multi-omics and deep learning.
  Camptothecin (CPT), a plant-derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering …
  pubmed Wang S, Wu X, Moreno M, Oh J 等 2026 Sep 置信度 0.82
• FYN, a Novel Target of Fragile X Mental Retardation Protein, Potentially Underlies ERK1/2 Hyperactivation in Fragile X Syndrome.
  Fragile X syndrome (FXS), the most common inherited form of intellectual disability and the leading monogenic cause of autism, results from the loss of the fragile X mental retardation protein (FMRP). Dysregulated translation of FMRP target mRNAs is believed t…
  pubmed Huang W, Jiang L, Zhu Y, Duan R 等 2026 Aug 5 置信度 0.82
• A versatile, low-cost, and reusable hydroponic system for the cultivation of plants of various species.
  Hydroponic systems are important tools in plant research, as the roots of plants cultivated in hydroponic systems can be easily observed, treated, and sampled. However, the application of many hydroponic systems in research is constrained by species specificit…
  pubmed Zhang J, Zhang X, Qian M, Wu J 2026 Aug 6 置信度 0.82
• Synergistic SHH activation and BMP inhibition remodel progenitor niche for enhanced hair cell generation.
  Hair cell regeneration from supporting cells declines rapidly during early postnatal development, limiting therapeutic applications. We demonstrate that strategic microenvironmental remodeling can dramatically enhance inner ear progenitor cell (IEPC) function …
  pubmed Li C, He D, Tang W, Fu L 等 2026 Aug 3 置信度 0.82
• Ultrasound-targeted cavitation induced tumor vascular normalization and radiotherapy sensitization in breast cancer.
  The limited therapeutic efficacy of radiotherapy (RT) in breast cancer is closely linked to hypoxia, which is caused by structurally abnormal vascular networks in the tumor microenvironment (TME). Tumor vascular normalization has emerged as a promising strateg…
  pubmed Liu Z, Yang H, Zhang Z, Kuang C 等 2026 Aug 3 置信度 0.82
• Organelle-specific fluorescent probes for live imaging at the nanoscale.
  Intracellular organelles are structures within cells that compartmentalize biochemical reactions for advanced cellular functions. Historically, synthetic dyes that target various cellular targets have been the mainstay for modern cell biology, which are subseq…
  pubmed Liu T, Zhang Z, Chen Z 2026 Aug 3 置信度 0.82
• Vascular smooth muscle cell FTO deletion aggravates atherosclerotic plaque instability by promoting VSMC migration through the N(6)-methyladenosine modification of the COL3A1 mRNA.
  Vascular smooth muscle cell (VSMC) migration is the key event in the pathogenesis of atherosclerosis (AS) and plaque instability. Trimethylamine-N-oxide (TMAO) induces VSMC migration to promote the progression of AS. However, the effects of the N 6 -methyladen…
  pubmed Yang Z, Deng K, Wu J, Wu N 等 2026 Aug 3 置信度 0.82
• Norepinephrine and dopamine sensor crosstalk depends on local innervation density.
  G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual neurotransmitters, sensor specificity in the brai…
  pubmed López RC, Noble N, Özçete ÖD, Silenzi L 等 2026 Aug 5 置信度 0.82
• Damage recognition by intestinal stem cells via Draper promotes adult Drosophila midgut regeneration.
  Tissue regeneration after injury is crucial for restoring epithelial structure and function. Upon damage, a regenerative microenvironment forms that provides signalling cues that stimulate stem cell proliferation to replace lost cells. While this process is we…
  pubmed Legido M, Srotyr M, Wafer R, Patel PH 2026 Aug 5 置信度 0.82
• Author Correction: Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity.
  pubmed Wang S, Dai T, Qin Z, Pan T 等 2026 Aug 5 置信度 0.82
• Identifying marker-trait associations for wheat stem sawfly resistance.
  Two novel WSS resistance loci were identified on chromosomes 2B and 5A. Characterization of WSS resistance loci will improve breeders' ability to select to reduce yield loss due to WSS. Wheat stem sawfly (WSS) is a native grass feeding pest of winter wheat (Tr…
  pubmed Hammers M, Winn ZJ, Rice B, Nachappa P 等 2026 Aug 5 置信度 0.82
• Palmitoylation modulates neutrophil anti-tumour function in liver metastasis.
  pubmed Zhou L, Cui J 2026 Aug 5 置信度 0.82
• RanBP2 promotes ferroptosis resistance and compromises therapeutic response by stabilizing SLC7A1 through LRSAM1 SUMOylation and ubiquitination in lung adenocarcinoma.
  SUMOylation is characterized as a ubiquitin-like post-translational modification that exhibits mechanistic similarities with ubiquitination. Importantly, it modulates the ubiquitination levels of some target proteins, thereby influencing protein stability. Dys…
  pubmed Guo S, Zeng Y, Zhang Q, Zhao X 等 2026 Aug 5 置信度 0.82
• The beneficial relation between soil organic carbon and maize yield in field trials does not translate to real-world farms in Northeast China.
  Carbon sequestration in agricultural soils is an economically viable pathway to achieve climate and food co-benefits, but it remains unclear whether the positive soil organic carbon (SOC)-yield relationship observed in field trials applies to real-world farms.…
  pubmed Zhao S, Schmidt S, Quan Z, Li F 等 2026 Aug 5 置信度 0.82
• IL-1 family signalling drives mucosal defence against systemic Candida albicans infection.
  Candida albicans is a major opportunistic pathogen in humans that is capable of breaching mucosal barriers and causing severe systemic infections with high mortality. How the host controls mucosal infection and prevents dissemination remains unclear but is ess…
  pubmed Griffiths JS, Kempf A, Pickering RJ, Priest EL 等 2026 Aug 5 置信度 0.82
• Dual SGLT1/2 inhibition with sotagliflozin improves cardiac function and metabolism in type 2 diabetic mice.
  Sotagliflozin (SOTA), a dual sodium-glucose cotransporter (SGLT)1/2 inhibitor, improves cardiovascular outcomes in patients with diabetes and heart failure, yet the metabolic mechanisms underlying these benefits remain incompletely defined. As a model of type …
  pubmed Young M, Dambure S, Cullen F, Jarrah K 等 2026 Aug 5 置信度 0.82
• Extensive climate-induced range shifts in butterflies across the globe.
  Global changes are leading to widespread species redistribution. Comprehensive assessments of range shift dynamics and their drivers are difficult, partly due to the variation in range shift detection over space and taxa. Here we compile documented range shift…
  pubmed Chowdhury S, Aich U, Antão LH, Pinkert S 等 2026 Aug 5 置信度 0.82
• Editorial Expression of Concern: Tumour exosome integrins determine organotropic metastasis.
  pubmed Hoshino A, Costa-Silva B, Shen TL, Rodrigues G 等 2026 Aug 5 置信度 0.82
• An expanded codebook of human transcription factor DNA-binding specificity.
  Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs 1 . Furthermore, even for well-charact…
  pubmed Jolma A, Laverty KU, Fathi A, Yang AWH 等 2026 Aug 5 置信度 0.82
• The Virtual Tissues foundation model resolves spatial proteomics across scales.
  Spatial proteomics technologies have transformed our understanding of complex tissue architecture in cancer but present unique challenges for computational analysis 1 . Each study uses a different marker panel and protocol, and most methods are tailored to sin…
  pubmed Wenckstern J, Jain E, von Querfurth B, Cheng Y 等 2026 Aug 5 置信度 0.82
• Virus reactivation in acute and long COVID-19.
  Chronic viral infections are ubiquitous in humans, with individuals carrying multiple viruses that can reactivate during physiological stress, including severe illness 1 . Notably, SARS-CoV-2 infection has been shown to reactivate chronic viruses such as …
  pubmed Maguire C, Chen J, Rouphael N, Morse BA 等 2026 Aug 5 置信度 0.82
• Asymmetric distribution of mitochondrial Ca(2+) regulators specifies compartment-specific mitochondrial function and neuronal development.
  Neuronal polarization is essential for functional compartmentalization, enabling dendritic synaptic integration and axonal action potential generation. Although structural differences in mitochondria across compartments have been identified, their functional d…
  pubmed Jang DC, Kim SY, Kim WS, Choi IY 等 2026 Aug 5 置信度 0.82
• Dr. Juliet M. Daniel (1964-2026): Dancing to the Rhythm of Kaiso.
  pubmed Robinson SC, Longo J, Bassey-Archibong B, Lessey LR 等 2026 Aug 5 置信度 0.82
• Expanding the supply of human leukocytes for research by harvesting cell concentrates from Trima Accel tubing sets.
  Leukoreduction system (LRS) chambers from the Trima Accel apheresis platform are widely used as a convenient source of human peripheral blood mononuclear cells (PBMCs) for immunological research. However, increasing demand has prompted the search for alternati…
  pubmed Kronenberg K, Glehr G, Haehnel V, Dormann F 等 2026 Aug 5 置信度 0.82
• Closing the sepsis gap: from molecular mechanisms to scalable bedside care.
  Recent estimates point to roughly 49 million cases and 11-13 million deaths annually due to sepsis, with a disproportionate burden borne by low- and middle-income countries. Three decades of progress, summarised in the recently updated Surviving Sepsis Campaig…
  pubmed Reyes LF, Laudanski K 2026 Aug 5 置信度 0.82
• Integrated One-Health analysis of antimicrobial resistance, biofilm formation, and genetic relatedness of Enterococcus spp. at the human-food interface.
  Enterococcus species are opportunistic pathogens and reservoirs of antimicrobial resistance (AMR) that can be transmitted through food chain. This study investigated Enterococcus faecalis and Enterococcus faecium isolated from retail meat, workers and consumer…
  pubmed Ahmed HA, El Feky TM, Shalaby M, Elsotohy ME 等 2026 Aug 5 置信度 0.82
• Task geometry alignment enables parameter independent and accurate genomic search.
  Standard sequence alignment models biological homology through the metric space of edit distance. While effective for global orthology, this rigid geometric assumption struggles with discrete biological realities-such as insertions/deletions (indels) and fragm…
  pubmed Boone J 2026 Aug 5 置信度 0.82
• Multi-scale ecosystem service dataset for Southern Hilly Region of China (1990-2024).
  Ecosystem services are spatially heterogeneous and scale dependent, which makes long-term and cross-scale datasets essential for regional ecological assessment and environmental management. However, for the Southern Hilly Region of China (SHR), ecosystem servi…
  pubmed Tang Z, Wu Y, Ding C, Song H 等 2026 Jul 25 置信度 0.82
• Systems Biology Graphical Notation
  crossref 2013-07-03T21:04:23Z 置信度 0.70
• Systems Biology: Toward System-level Understanding of Biological Systems
  crossref Hiroaki Kitano 2018-12-14T02:28:05Z 置信度 0.70
• Guest Editorial
  crossref Luonan Chen 2013-09-25T14:22:10Z 置信度 0.70
• Systems Biology: A Perspective
  crossref 2023-11-02T06:48:45Z 置信度 0.70
• Scientific Challenges in Systems Biology
  crossref Hiroaki Kitano 2008-05-16T04:58:45Z 置信度 0.70
• Editorial: Part 1: Network biology in translational bioinformatics and systems biology
  crossref Xing‐Ming Zhao 2014-04-01T09:10:23Z 置信度 0.70
• Recombinant Genomes: Novel Resources for Systems Biology and Synthetic Biology
  crossref Mitsuhiro Itaya 2009-09-22T20:46:30Z 置信度 0.70
• Ontologies in Bioinformatics and Systems Biology
  crossref Patrick Lambrix 2007-09-28T18:57:40Z 置信度 0.70