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• Advancing lung cancer therapy - leveraging cell biology to improve immunotherapy and anti-angiogenic strategies.
  europepmc 2026 置信度 0.80
• Intravital Microscopy of Osteocytes: A New Era in Bone Cell Biology.
  europepmc 2025 置信度 0.80
• A comprehensive overview of yeast libraries and their role in advancing cell biology.
  europepmc 2026 置信度 0.80
• Ganodermanontriol and Lanostane Triterpenoid Derivatives in Cancer Cell Biology: Signaling Network Modulation, Cell-Cycle Control and Tumor Microenvironment Reprogramming.
  europepmc 2026 置信度 0.80
• Notebook-based alignment of human and agentic reasoning in single-cell biology
  Agentic AI is increasingly deployed on complex problems, often using chain-of-thought prompting to ground predictions in stepwise reasoning. In biomedical research, assistive agents could make this reasoning accessible to human scientists: for example, interme…
  europepmc 2025 置信度 0.80
• Adaptation of lentiviral vectors for viral gene therapy and their impact on host cell biology.
  europepmc 2026 置信度 0.80
• An Advanced Mobile Laboratory to enable field-based microbial ecology and cell biology across scales
  europepmc 2026 置信度 0.80
• Genetic ablation of TRPC6 facilitated age-dependent atherosclerosis progression in an ApoE-/- mouse model.
  TRPC6 channels are expressed in endothelial cells, smooth muscle cells, and macrophages within the atherosclerotic segments of conduit blood vessels. Genetic or pharmacological inactivation of TRPC6 was variably associated with the development of atheroscleros…
  pubmed Demaree IS, Munjuluri S, Boyapalli S, Beaty RE 等 2026 置信度 0.82
• S-layer architecture and glycosylation and their role in shaping virus-host specificity in prokaryotes.
  The crystalline surface layer (S-layer) of prokaryotes constitutes a critical macromolecular interface governing virus-host interactions. In this review, we synthesize recent findings regarding the role of S-layer glycoproteins as viral receptors, examine the …
  pubmed Schwarzer S, Atlason ÚÁ, Quax TEF 2026 置信度 0.82
• Functional heterogeneity of TP53 mutants in venetoclax-resistant AML: mechanisms, clinical implications, and therapeutic opportunities.
  TP53 mutations are strongly associated with resistance to venetoclax in acute myeloid leukemia (AML) and represent a major challenge in current treatment strategies. Importantly, different TP53 mutants exhibit substantial functional heterogeneity, leading to d…
  pubmed Maimaitituerhong M, Xiao J, Gao W, Zheng R 等 2026 置信度 0.82
• From biology to morphology and treatment: the current role of pathology in penile cancer - a narrative review.
  Penile carcinoma is a rare but psychosexually devastating malignancy associated with the worst prognosis among male-specific genitourinary malignancies (prostate, testicular, and penile cancer). In addition to loss of the organ itself, patients frequently suff…
  pubmed Hrudka J, Zavillová N, Hojný J, Waldauf P 等 2026 置信度 0.82
• Lipedema as a hormone-sensitive stromal disorder: a four-pathway translational framework.
  Lipedema is a chronic disorder of subcutaneous adipose tissue characterized by disproportionate fat accumulation, pain, and progressive functional impairment, predominantly affecting women. Research remains fragmented across vascular, hormonal, metabolic, and …
  pubmed Viana DPDC, Invitti AL, Schor E 2026 置信度 0.82
• Biological and clinical stability after switching from intravenous to subcutaneous natalizumab in RRMS under standard and extended dosing.
  Natalizumab (NTZ) is a high-efficacy therapy for relapsing-remitting multiple sclerosis (RRMS) that can be administered intravenously (IV) or subcutaneously (SC). While switching from IV to SC NTZ is increasingly common in clinical practice, evidence on pharma…
  pubmed Agundez-Moreno A, Presas-Rodríguez S, González-García AM, Teniente-Serra A 等 2026 置信度 0.82
• Integrative precision oncology in neuroblastoma: multi-omics biomarkers, molecular targets, and immunotherapeutic strategies.
  Neuroblastoma is the most frequent extracranial solid tumor of young children and demonstrates a wide range of biological behavior, from spontaneous regression to highly aggressive metastatic disease. Recent advances in genomics, epigenetics, tumor microenviro…
  pubmed Singh A, Goel N, Mehndiratta S, Chaudhry A 等 2026 置信度 0.82
• Nuclear IL-33 amplifies NF-κB signaling to drive neutrophil recruitment and activation in the endocervical epithelium during Mycoplasma genitalium infection.
  Mycoplasma genitalium has emerged as a clinically significant etiology of sexually transmitted infections that often establishes persistent infections within the female reproductive tract. Although the recruitment of neutrophils is a characteristic feature of …
  pubmed Tian Y, Li K, Xie N, Zhang C 等 2026 置信度 0.82
• Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice.
  Dysregulation of the PTEN-mTORC1 signaling pathway disrupts cellular metabolism and contributes to neurodevelopmental disorders, including autism spectrum disorder (ASD). In cerebellar Purkinje cells (PCs), PTEN deficiency leads to hyperactivation of mTORC1, i…
  pubmed Brazier SR, Ditrano KL, Betancourt-Trompa DS, Belt GA 等 2026 置信度 0.82
• Metabolic pathways fueling human spermatozoa capacitation and hyperactivation: a roadmap for spermatozoa bioenergetics.
  Human spermatozoa are highly specialized cells whose function depends on tightly regulated metabolic and signaling networks. Following spermatogenesis and epididymal maturation, ejaculated spermatozoa must undergo capacitation in the female reproductive tract,…
  pubmed Gonçalves EV, Carrageta DF, Guerra-Carvalho B, Sousa M 等 2026 置信度 0.82
• Redefining the concept of resectability in the landscape of perioperative treatments for lung cancer.
  Resectability in non-small cell lung cancer (NSCLC) is shifting from a purely anatomic and surgical concept, based on technical feasibility of an R0 resection, to an integrated, multidisciplinary determination that incorporates tumor biology, expected benefit …
  pubmed Petrella F, Cara A, Cassina EM, Dell'Agosto J 等 2026 置信度 0.82
• Antigen processing machinery deficits in head and neck cancers: mechanisms of immune evasion and strategies for therapeutic restoration.
  The efficacy of T-cell based immunotherapies relies on the presentation of tumor-specific antigens via the major histocompatibility complex (MHC) class I pathway. In head and neck squamous cell carcinoma (HNSCC), most patients display primary or acquired resis…
  pubmed Iyer P, Kinney BLC, Brammer B, Lee MY 等 2026 置信度 0.82
• Dual Lineage Tracing Identifies Cellular Mechanisms Underlying Radiation-Associated Changes in Atherosclerotic Lesion Composition.
  Phenotypic plasticity of smooth muscle cells (SMCs) and endothelial cells (ECs) contributes to atherosclerotic plaque composition and stability, yet how shifts in one population influence the contribution and function of the other under conditions of vascular …
  pubmed Deaton RA, Raihan T, Milosek VM, Allaham F 等 2026 Aug 6 置信度 0.82
• Identifying Pulmonary Endothelial Cell Zonation From Single-Cell Transcriptomics.
  The lung vasculature is comprised of a series of branching vessels extending from the main pulmonary artery to the alveolar capillaries, then back to the pulmonary veins. Lung endothelial cells (EC) exist along this continuum, exposed to gradients of shear str…
  pubmed Sveiven SN, Knutsen C, Zanini F, Cornfield DN 等 2026 Aug 6 置信度 0.82
• Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?
  Epilepsy is one of the most common neurological disorders worldwide, affecting around 1% of the population. The epilepsies represent a diverse group of conditions, ranging from acquired forms resulting from neurological insults to common multifactorial epileps…
  pubmed Lange J, Zhao E, O'Connell E, Gillham O 等 2026 Aug 置信度 0.82
• Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells in vitro.
  T cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. While transcriptional, epigenetic, and metabolic rewiring have been well…
  pubmed Pledger ES, Ambavaram N, Ferguson L, Cate JHD 2026 Aug 6 置信度 0.82
• Darunavir and Fosamprenavir Inhibit Zika Virus Replication via Dual Targeting of the Envelope Protein and NS2B-NS3 Protease.
  Zika virus (ZIKV) remains a significant global health concern, underscoring the need for effective antiviral agents. In this study, we evaluated the antiviral activity and mechanisms of the HIV protease inhibitors darunavir (DRV), fosamprenavir (FPV), and ampr…
  pubmed Kan JY, Su HC, Lai HC, Lin YF 等 2026 Aug 置信度 0.82
• Diabetes-Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype.
  To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high-fat, high-sucrose diet (HFHSD), conceivably leading to bladder underactivity…
  pubmed Borhani Peikani M, Perrino BA, Mutafova-Yambolieva VN 2026 Aug 6 置信度 0.82
• Mohs Margins in Stage-1-Positive Basal Cell Carcinoma Are Often Histologically Shallow Irrespective of Biopsy Subtype: A Retrospective Analysis Using Histologic Depth as a Surrogate for In Vivo Imaging Detectability.
  Presurgical biopsy subtype guides basal cell carcinoma (BCC) risk stratification, but how well it predicts histopathology at the Mohs margin is unclear. Noninvasive imaging with reflectance confocal microscopy (RCM), line-field confocal optical coherence tomog…
  pubmed Boostani M, Goorman EJ, Bax MJ, Brady KL 等 2026 Aug 5 置信度 0.82
• Technology acceptance of machine learning in life sciences: the role of hype perception and journal impact factor
  europepmc 2026 置信度 0.80
• Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences.
  europepmc 2026 置信度 0.80
• Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.
  europepmc 2026 置信度 0.80
• Credit, recognition, and reward for non-traditional research artefacts in the Life Sciences
  europepmc 2026 置信度 0.80
• Good Data Governance Practice and a Grading Initiative for Life Sciences Data.
  europepmc 2026 置信度 0.80
• Life sciences and anxiety - Between enlightenment and uncertainty.
  europepmc 2025-11-19T22:15:33Z 置信度 0.80
• Life sciences and artificial intelligence.
  europepmc 2025 置信度 0.80
• Super-resolution microscopy: revolutionizing life sciences through advanced resolution.
  With the rapid revolution in super-resolution microscopy, the resolution of far-field optical microscopy has entered the sub-nanometer era, providing new insights into macromolecules in vitro and in situ .
  europepmc 2026 置信度 0.80
• The missing link in FAIR data policy: biodata resources in life sciences.
  europepmc 2026 置信度 0.80
• Spatial Detection of Pb in Life Sciences: Advances and Limitations.
  europepmc 2025 置信度 0.80
• Life sciences and society - an alphabetical journey.
  europepmc 2025 置信度 0.80
• Integrity of Data in Life Sciences: Essential for Sustaining Research Progress
  The progress, reproducibility, and validity of life sciences research depend on maintaining robust data integrity. The complete need for truthful and transparent data practices highlights the severe implications of data fabrication and falsification, including…
  europepmc Mahmoudnm K. Singer 2025 置信度 0.80
• Codes across (life)sciences.
  europepmc 2025 置信度 0.80
• The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence.
  A group of researchers from the humanities, economics, social sciences, natural and life science developed a definition of the topics complexity and emergence that can be applied across disciplines. Here, concepts of complexity and emergence in chemistry and b…
  europepmc 2026 置信度 0.80
• An ELIXIR scoping review on domain-specific evaluation metrics for synthetic data in life sciences.
  europepmc 2026 置信度 0.80
• MAL Unified General Dynamics Theory: The Median Principle for Algorithmic Digital R&D in Life Sciences and Cross-Disciplinary Informatics
  The Universe has two domains: Life and Non-Life, which manifest the dimensionless relativity ratio with basic codes. For life is a/b = a/(1-a) = (1-b)/b (Floating Ratio), and for Non-Life is a/b = (a + b)/a = 1 + b/a, or (Golden Ratio). Life and Non-Life can b…
  europepmc Ting-Chao Chou 2026 置信度 0.80
• Parameter-wise predictions and sensitivity analysis for random walk models in the life sciences.
  europepmc 2026 置信度 0.80
• Mapping the AI Landscape in Life Sciences: A Framework for Evaluation and Adoption.
  europepmc 2025 置信度 0.80
• RDMkit: A research data management toolkit for life sciences.
  europepmc 2025 置信度 0.80
• Highlighting the contribution of women in life sciences - Latin America.
  europepmc 2025 置信度 0.80
• Beyond the lab coat: methodological challenges in space life sciences.
  europepmc 2025 置信度 0.80
• Magnetic Nanoparticles: Synthesis and Applications in Life Sciences.
  europepmc 2025 置信度 0.80
• The Story behind the Science: Preprints of pandemic potential-how bioRxiv and medRxiv brought preprints to the life sciences.
  europepmc 2026 置信度 0.80
• A possible turning point for research governance in the life sciences.
  europepmc 2025 置信度 0.80
• Incorporation of the Trifluoromethylthio Group (CF<sub>3</sub>S-) into Biomolecules: A Versatile Tool for Advancing Life Sciences.
  europepmc 2026 置信度 0.80
• Two breakthroughs recommended by BSC recognized as Top 10 Scientific Advances in Life Sciences of China 2025.
  europepmc 2026 置信度 0.80
• Literature highlights column: From the literature: Life Sciences Discovery and Technology Highlights.
  europepmc 2026 置信度 0.80
• On the Effectiveness of Sparse Identification Methods to Detect Nonlinear Models of Oscillatory Dynamics in Psychology and the Life Sciences.
  europepmc 2026 置信度 0.80
• Python-Based Interactive Notebooks for Teaching AI and Data Science to Undergraduate Students in the Life Sciences.
  europepmc 2026 置信度 0.80
• Career development awards support early-stage researchers in life sciences entrepreneurship.
  europepmc 2025 置信度 0.80
• Multiplicity corrections in life sciences: challenges and consequences.
  europepmc 2025 置信度 0.80
• Towards AI-Ready Datasets for the Life Sciences
  europepmc 2025 置信度 0.80
• Enabling global image data sharing in the life sciences.
  europepmc 2025 置信度 0.80
• Converge2Xcelerate (ConV2X) Driving Platforms and Decentralized Technology in Healthcare and Life Sciences: Keynote Address: Existential Times.
  europepmc 2025 置信度 0.80
• BioBricks.ai: a versioned data registry for life sciences data assets.
  europepmc 2025 置信度 0.80
• Helping Students See and Identify Purpose and Relevance in Life Sciences Courses.
  europepmc 2025 置信度 0.80
• Nanopipettes for Chemical Analysis in Life Sciences.
  europepmc 2025 置信度 0.80
• Advancing Life Sciences and Biotechnology in Saudi Arabia: A Comprehensive Overview of the Saudi Biobank Project Study Design and Aspirations.
  europepmc 2026 置信度 0.80
• From Data to Knowledge. Advancing Life Sciences: Editorial for the CEN2023 Special Issue.
  europepmc 2025 置信度 0.80
• Molecular life sciences in the era of the Fourth Industrial Revolution: sequencing, multi-omics and artificial intelligence.
  europepmc 2025 置信度 0.80
• Mapping the AI Life Sciences Landscape in Greece: A National Survey and Bibliometric Comparison with Global Trends
  ABSTRACT Artificial intelligence is increasingly used in Life Sciences, though the pace and direction of adoption varies widely across countries. To map the Greek landscape, we combined two complementary approaches, a data-driven analysis of 916,824 AI-related…
  europepmc 2025 置信度 0.80
• Transforming Molecular Life Sciences Education: Past, Current, and Future Insights and Practices.
  europepmc 2025 置信度 0.80
• Attitudes of medical and life sciences university students and postdoctoral fellows toward AI chatbots in education: an international cross-sectional survey.
  europepmc 2026 置信度 0.80
• Examining funding policies for postdoctoral researchers in life sciences: a case study of Shandong University.
  europepmc 2025 置信度 0.80
• The Age of AI in the Life Sciences: Benefits and Biosecurity Considerations
  europepmc 2025 置信度 0.80
• Corrigendum to "Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: Insight into NLRP3 inflammasome and SPHK1/S1P/hippo signaling modulation" [life sciences 336 (2024) 122272].
  europepmc Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy 2026 置信度 0.80
• Using <i>Elicit</i> AI research assistant for data extraction in systematic reviews: A feasibility study across environmental and life sciences.
  europepmc 2026 置信度 0.80
• Biomimetic separations in chemistry and life sciences.
  europepmc 2025 置信度 0.80
• The potential of an Innovative Licensing and Access Pathway metapolicy on the United Kingdom's life sciences strategy.
  europepmc 2025 置信度 0.80
• Sources and Applications of Tyrosinase in Life Sciences.
  europepmc 2025 置信度 0.80
• Report on the 4th FEBS-IUBMB-ENABLE International Molecular Biosciences PhD and Postdoc Conference 2025: "Bridging minds - Interdisciplinary research for the future of life sciences".
  europepmc 2026 置信度 0.80
• Organ medicine: New concept of life sciences.
  europepmc 2025 置信度 0.80
• BioHackSWAT4HCLS25 report: Towards AI-Ready Datasets for the Life Sciences
  europepmc 2025 置信度 0.80
• Editorial and Call for Papers for Transforming Molecular Life Sciences Education: Past, Current, and Future Insights and Practices.
  europepmc 2025 置信度 0.80
• Citation Contamination by Paper Mill Articles in Systematic Reviews of the Life Sciences.
  europepmc 2025 置信度 0.80
• A comprehensive evaluation of life sciences data resources reveals significant accessibility barriers.
  europepmc 2025 置信度 0.80
• An exploration of the impact of educational background on basic science and life sciences librarians.
  europepmc 2025 置信度 0.80
• Retraction notice to "In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma" [Life Sciences 285 (2021) 119961].
  europepmc Ahmed M. Mamdouh, Dina M. Khodeer, Mohamed A. Tantawy, Yasser M. Moustafa 2026 置信度 0.80
• Innovation to investment: how to build your first life sciences pitch deck.
  europepmc 2025 置信度 0.80
• A year in the molecular life sciences: 2024 highlights.
  europepmc 2025 置信度 0.80
• An open source for multiplexed, stable and transient flows to advance life sciences using microfluidic control automation.
  europepmc 2025 置信度 0.80
• Bridging BioSciences and technology: The impact of AI & GenAI in life sciences and agribusiness.
  europepmc 2025 置信度 0.80
• Trust, but Verify: A "Just Culture" Model for Oversight of Potentially High-Risk Life Sciences Research.
  europepmc 2025 置信度 0.80
• AI reshaping life sciences: intelligent transformation, application challenges, and future convergence in neuroscience, biology, and medicine.
  europepmc 2025 置信度 0.80
• Enabling research and development innovation in the life sciences: A case study.
  europepmc 2025 置信度 0.80
• Nonlocal models in biology and life sciences: Sources, developments, and applications.
  europepmc 2025 置信度 0.80
• Recombinant Bacillus subtilis spores expressing cholera toxin B and ovalbumin prevent ovalbumin-specific food allergy in mice by upregulating regulatory T cells and modulating gut microbiome flora.
  Although oral immunotherapy has shown clinical efficacy in treating food allergies, its broader implementation is constrained by the occurrence of adverse effects. Consequently, inducing allergen-specific immune tolerance during early life can be a preventive …
  pubmed Xiong Z, Liu X, Deng X, Zhang C 等 2026 置信度 0.82
• Real-world quality of life and sleep outcomes in patients treated with THC- and CBD-rich Cannabis oil: a cross-sectional study.
  The endocannabinoid system plays an important role in the modulation of pain, mood, sleep, and subjective wellbeing. Despite the growing clinical use of medicinal Cannabis , real-world data simultaneously evaluating quality of life and sleep-related outcomes i…
  pubmed Figueiredo JFLM, de Almeida Soares C, de Oliveira DA, Cassiano FR 等 2026 置信度 0.82
• Pan-cancer multi-omics analysis of pharmacogenomic alterations.
  Pharmacogenomic (PGx) variation is an important determinant of inter-individual variability in drug response. While germline pharmacogenomics has been extensively studied, somatic alterations affecting these pharmacogenes in tumors remain less systematically c…
  pubmed AlMulla A, Kaur S, Balyan P, Al-Saafin S 等 2026 置信度 0.82
• Associations of health and lifestyle factors with multidimensional quality of life among women with endometriosis: a cross-sectional study.
  Endometriosis is a chronic disease associated with pain, fertility difficulties, and reduced quality of life (QoL). Beyond clinical symptoms, health-related and lifestyle behaviors may influence the long-term impact of the disease. This study aimed to assess m…
  pubmed Matek Sarić M, Ljubičić M, Sorić T, Sarić A 等 2026 置信度 0.82
• Towards a personalized perspective on gliomas: an epigenetic-immuno-inflammatory aging framework.
  High-grade gliomas cannot be fully understood without considering the biology of aging. In this study, we demonstrate that a set of genes previously established as predictors of tumor subtype and patient survival in gliomas can also be independently characteri…
  pubmed Vershinina O, Turubanova V, Franceschi C, Ivanchenko M 2026 置信度 0.82
• Soil and genotype-driven resource allocation trade-offs shape root exudation across crop species.
  Root exudates play a central role in rhizosphere processes, many of which support plant growth. While increased exudation under abiotic stresses has been frequently linked to enhanced plant resilience, crop- and genotype- and soil-specific exudation patterns u…
  pubmed Schwalm H, Escudero-Martinez C, Brown M, Brown L 等 2026 置信度 0.82
• Thoracic aortic disease in young patients: from genetics to management.
  Thoracic aortic disease in young patients is often driven by congenital, syndromic, or heritable disorders. Risk for adverse events in these patients is not fully captured by aortic diameter alone. This mini-review describes the shift in management beyond a di…
  pubmed Fatehi Hassanabad A, McKenzie MP, Keir M, Fedak PWM 2026 置信度 0.82
• Move in nature, get strong with smart sports: physical activity habits and health-related psychological factors among adults exercising in green and smart sports environments.
  Sedentary lifestyles threaten physical and psychological well-being. Nature-integrated green sports environments and digitally supported smart sports environments may promote physical activity and sustainable health. This study examined the direct and indirect…
  pubmed Ulukan M, Bingölbalı N, Tuncer M, Karakulak İ 等 2026 置信度 0.82