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Recent studies have suggested that several oncogenic and tumor-suppressive proteins carry out their functions in the context of specific membrane-less cellular compartments. As these compartments, generally referred to as onco-condensates, are specific to tumo…
pubmed
Jevtic Z, Allram M, Grebien F, Schwaller J
2023 Jul
置信度 0.82
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Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode switch in serum-starving or ischemic/reperfusion models in vitro …
pubmed
Ueda H
2023 Jun 6
置信度 0.82
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There is a growing use of radionuclide therapy for the medical care of oncology patients, where radioactive pharmaceuticals are used to target and treat various cancer types. This paper provides a brief overview illustrating the spectrum of ongoing and recentl…
pubmed
Healy A, Ho E, Kuo P, Zukotynski K
2023
置信度 0.82
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In a study of Merkel cell carcinoma (MCC), a fusion transcript between MLH1 and SPATA4 was identified. This fusion has the potential to generate the inactive or dominant-negative form of the protein. Therefore, we aimed to investigate whether mismatch repair p…
pubmed
Kestel S, Ogut B, Inan MA, Erdem O
2023
置信度 0.82
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GLI1 -altered mesenchymal tumors are an emerging entity in soft tissue pathology. In the head and neck region, they are most commonly in the tongue. Limited published data indicate a propensity for local recurrence, regional spread, and distant metastasis in b…
pubmed
Godse NR, Alsulaimani S, Singh AD, Fletcher CD 等
2024 Oct
置信度 0.82
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Epithelioid and spindle cell sarcomas with NR1D1::MAML1/2 gene fusions are rare and emerging entities. Only six cases of NR1D1-rearranged mesenchymal tumors have previously been reported in the literature; they are often characterized by an epithelioid morphol…
pubmed
Warmke LM, Collier CD, Davis JL
2023 Nov
置信度 0.82
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Zinc finger protein 384 ( ZNF384 ) encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have be…
pubmed
Zhu L, Bai W, Cheng Q, Fang J
2023 Jan-Dec
置信度 0.82
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The pathology of poorly differentiated sinonasal malignancies has undergone a dynamic evolution during the last decade, resulting in a refined, mostly genetically or etiologically oriented classification of neoplasms in the historical spectrum of sin…
pubmed
Agaimy A
2023 Jul
置信度 0.82
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Spinal surgical procedures are becoming more common over the years, and imaging studies can be requested in the postoperative setting, such as a baseline study when implants are used, or when there is a new postoperative issue reported by the patient or even a…
pubmed
Girão MMV, Miyahara LK, Dwan VSY, Baptista E 等
2023 Jun 6
置信度 0.82
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Alveolar soft part sarcoma (ASPS) is characterized by distinctive histomorphology of variably discohesive epithelioid cells arranged in nests and translocation of t(x;17) (p11.2;q25) resulting in ASPSCR1-TFE3 fusion. The aim of the present study is to review t…
pubmed
Kaur K, Gami A, Shah A, Gandhi J 等
2024
置信度 0.82
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The incidence of thyroid cancer is increasing worldwide with the disease burden in Europe second only to that in Asia. In the last several decades, molecular pathways central to the pathogenesis of thyroid cancer have revealed a spectrum of targetable kinases/…
pubmed
Elisei R, Grande E, Kreissl MC, Leboulleux S 等
2023
置信度 0.82
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Positron emission tomography (PET)/computed tomography (CT) has become a critical tool in clinical oncology with an expanding role in guiding radiation treatment planning. As its application and availability grows, it is increasingly important for practicing r…
pubmed
Trotter J, Pantel AR, Teo BK, Escorcia FE 等
2023 Sep-Oct
置信度 0.82
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A growing emphasis has been paid to the function of mitochondria in tumors, neurodegenerative disorders (NDs), and cardiovascular diseases. Mitochondria are oxygen-sensitive organelles whose function depends on their structural basis. Mitochondrial dynamics ar…
pubmed
Xin Y, Zhao L, Peng R
2023 Aug
置信度 0.82
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Although pediatric thyroid tumors have many similarities to those occurring in adults, significant differences are also recognized. For example, although thyroid nodules in children are much less common than in adults, a higher percentage is malignant. Moreove…
pubmed
Slack JC, Hollowell M, Barletta JA
2023 Jun
置信度 0.82
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Acute myeloid leukaemias harbouring a rearrangement of the mixed lineage leukaemia gene (MLL) are aggressive haematopoietic malignancies that relapse early and have a poor prognosis (event-free survival less than 50%). Menin is a tumour suppressor, however, in…
pubmed
Dempke WCM, Desole M, Chiusolo P, Sica S 等
2023 Sep
置信度 0.82
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NUT midline carcinoma family member 1 (NUTM1) fusions were originally identified in poorly differentiated and clinically aggressive carcinomas typically located in the midline structures of children and young adults, and collectively known as NUT (midline) car…
pubmed
Charlab R, Racz R
2023 Aug
置信度 0.82
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Solitary fibrous tumor is a mesenchymal tumor of intermediate malignant potential characterized by a recurrent NAB2::STAT6 fusion and STAT6 nuclear expression. Primary thyroid solitary fibrous tumor is relatively uncommon, with 45 cases described in the Englis…
pubmed
Santoro F, Linari A, Maletta F, Parente R 等
2023 Aug
置信度 0.82
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Infantile fibrosarcoma is a rare non-rhabdomyosarcomatous soft tissue tumor (0.0005%) of which only 10% occur in the abdomen where they rarely affect the gastrointestinal tract. The median age at diagnosis is 3 months although 40% of them are present at birth.
pubmed
Soler PM, Duque MSR, Juan GM, Terán AKC 等
2023 Apr-Jun
置信度 0.82
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MEIS1::NCOA1/2 fusion sarcomas are a recently described novel entity arising in a variety of locations with a predilection for the genitourinary tract and gynecologic organs. Despite multiple locoregional recurrences, these tumors are thought to behave in a lo…
pubmed
Xing D, Meyer CF, Gross JM, Argani P 等
2024 Jan 1
置信度 0.82
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Nuclear egress of herpesvirus capsids across the intact nuclear envelope is an exceptional vesicle-mediated nucleocytoplasmic translocation resulting in the delivery of herpesvirus capsids into the cytosol. Budding of the (nucleo)capsid at and scission from th…
pubmed
Klupp BG, Mettenleiter TC
2023 Sep 29
置信度 0.82
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Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are associated with many aggressive cancers with poor patient outcomes. Several FOs are now understood to perform their oncogenic functions within biomolecular condensates formed thro…
pubmed
Shirnekhi HK, Chandra B, Kriwacki RW
2023 Apr
置信度 0.82
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Stabilization of bone structure and function involves multiple cell-to-cell and molecular interactions, in which the regulatory functions of post-translational modifications such as ubiquitination and deubiquitination shouldn't be underestimated. As the larges…
pubmed
Luo W, Zhang G, Wang Z, Wu Y 等
2023 May
置信度 0.82
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Radiotheranostics is a field of rapid growth with some approved treatments including 131 I for thyroid cancer, 223 Ra for osseous metastases, 177 Lu-DOTATATE for neuroendocrine tumors, and 177 Lu-PSMA (prostate-specific membrane antigen) for prostate cancer, a…
pubmed
Pomykala KL, Hadaschik BA, Sartor O, Gillessen S 等
2023 Jun
置信度 0.82
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As a form of clean energy, nuclear energy has unique advantages compared to other energy sources in the present era, where low-carbon policies are being widely advocated. The exponential growth of artificial intelligence (AI) technology in recent decades has r…
pubmed
Huang Q, Peng S, Deng J, Zeng H 等
2023 Mar
置信度 0.82
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As the immuno-oncology field continues the rapid growth witnessed over the past decade, optimising patient outcomes requires an evolution in the current response-assessment guidelines for phase 2 and 3 immunotherapy clinical trials and clinical care. Additiona…
pubmed
Shankar LK, Schöder H, Sharon E, Wolchok J 等
2023 Mar
置信度 0.82
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Since December 2019, the Coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly around the world, overburdening healthcare systems and creating significant global health concerns. …
pubmed
Tang WF, Tran AT, Wang LY, Horng JT
2023 Apr
置信度 0.82
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Mitochondria are essential for the health and viability of both motor and sensory neurons and their axons. Processes that disrupt their normal distribution and transport along axons will likely cause peripheral neuropathies. Similarly, mutations in mtDNA or nu…
pubmed
Horvath R, Medina J, Reilly MM, Shy ME 等
2023
置信度 0.82
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Mitochondrial optic neuropathies have a leading role in the field of mitochondrial medicine ever since 1988, when the first mutation in mitochondrial DNA was associated with Leber's hereditary optic neuropathy (LHON). Autosomal dominant optic atrophy (DOA) was…
pubmed
Carelli V, La Morgia C, Yu-Wai-Man P
2023
置信度 0.82
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Chronic neck or back pain is a common clinical problem. The most likely cause is degenerative change, whereas other causes are relatively rare. There is increasing evidence on using hybrid single-photon emission computed tomography (SPECT) to identify the pain…
pubmed
Varga M, Kantorová L, Langaufová A, Štulík J 等
2023 May
置信度 0.82
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Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is B…
pubmed
Chen J, Li M, Lu H
2023 Apr
置信度 0.82
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During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of these …
pubmed
Larkin R, Hermsen MA, London NR Jr
2023 Apr
置信度 0.82
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Myocardial perfusion single photon emission computed tomography (SPECT) is widely used in assessing coronary artery disease (CAD) owing to its proven efficacy in extensive clinical experience. Like other functional tests, myocardial SPECT is recommended for th…
pubmed
Maffeis C, Dondi F, Ribichini FL, Giubbini R 等
2023 Feb
置信度 0.82
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This prospective single-arm study is designed to compare in parallel 68Ga-PSMA PET/TRUS (transrectal or transperineal) fusion biopsy ("experimental test") with multiparametric MRI (mpMRI)/TRUS fusion prostate biopsy ("standard test") in men with a high suspici…
pubmed
Lopci E, Lazzeri M, Colombo P, Casale P 等
2023
置信度 0.82
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Technetium-101 ( 101 Tc) has been poorly studied in comparison with other Tc isotopes, although it was first identified over ~80 years ago shortly after the discovery of the element Tc itself. Its workable half-life and array of production modes, i.e., light/h…
pubmed
Johnstone EV, Mayordomo N, Mausolf EJ
2022 Oct 20
置信度 0.82
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Poorly differentiated thyroid carcinoma (PDTC) and high-grade differentiated thyroid carcinoma (HGDTC) are considered high-grade follicular-derived thyroid carcinomas, with prognoses intermediate between well-differentiated and anaplastic thyroid carcinoma. Bo…
pubmed
Cracolici V, Cipriani NA
2023 Mar
置信度 0.82
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By their unique compositions and microstructures, recently developed high-entropy materials (HEMs) exhibit outstanding properties and performance above the threshold of traditional materials. Wear- and erosion-resistant materials are of significant interest fo…
pubmed
Feltrin AC, Xing Q, Akinwekomi AD, Waseem OA 等
2022 Dec 30
置信度 0.82
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Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mut…
pubmed
Sharma D, Sharma N, Manchanda N, Prasad SK 等
2022 Dec 21
置信度 0.82
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Perivascular epithelioid cell neoplasms (PEComas) are a family of mesenchymal tumors with features of both smooth muscle and melanocytic differentiation. A subset of PEComas demonstrate rearrangements involving the TFE3 (Xp11) locus. Xp11 translocation PEComa …
pubmed
Zhang H, Wang S, Meng L
2023 Jan 16
置信度 0.82
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Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biologic potential, which occurs mostly in the lung and abdomen cavity of children and young adults. Uterine IMTs are rare. Herein, we presented clinicopathologic features of 4 …
pubmed
Zhang L, Luan L, Shen L, Xue R 等
2023 Mar
置信度 0.82
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The dynamics of energetic particles and tearing modes and the interactions between them are of great significance for magnetically confined fusion plasmas. In this review, we focus on these issues in the context of tokamak plasmas. The interaction between ener…
pubmed
Cai H, Li D
2022 Nov
置信度 0.82
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Warburg effect is characterized by excessive consumption of glucose by the tumor cells under both aerobic and hypoxic conditions. This metabolic reprogramming allows the tumor cells to adapt to the unique microenvironment and proliferate rapidly, and also prom…
pubmed
Yang H, Wang J, Huang G
2022
置信度 0.82
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Akhil Kapoor Introduction  The prognosis of anaplastic lymphoma kinase (ALK) fusion-positive metastatic non-small cell lung cancer (mNSCLC) patients has improved drastically since the introduction of targeted therapies. Apart from age, performance statu…
pubmed
Khaddar S, Kapoor A, Noronha V, Patil VM 等
2022 Jul
置信度 0.82
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The association of airborne particulate matter exposure with the deteriorating function of the cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear crosstalk orchestrated by aberrant redox signaling. The loss of delicate bal…
pubmed
Rehman A, Kumari R, Kamthan A, Tiwari R 等
2023 Feb 1
置信度 0.82
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Molecular mutations and alterations play a role in thyroid tumorigenesis. Different alterations are associated with different clinical and pathological characteristics. Copy number alterations (CNAs) are known to be present in some thyroid tumors; however, the…
pubmed
Rajab M, Bandargal S, Pusztaszeri MP, Forest VI 等
2022 Dec 13
置信度 0.82
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The objective of the present study is to evaluate the anatomy of the inferior hypogastric plexus, correlating it with urological pathologies, imaging exams and surgeries of the female pelvis, especially for treatment of endometriosis.
pubmed
Ribeiro-Julio GS, Pereira JA, Ribeiro E, Gallo CM 等
2023 May-Jun
置信度 0.82
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Few analytical or research works claim that the negative impact of improper use of ASEs may be comparable with that of hydrocarbons and sometimes even greater. It has become a common view that "green" energy (ASE) is clean, safe and environmentally friendly (e…
pubmed
Boguslavsky DV, Sharov KS, Sharova NP
2022 Dec 5
置信度 0.82
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Porocarcinomas are rare tumors derived from the acrosyringium and eccrine ducts, which most commonly occur on the lower extremities or head and neck region in older adults. Microscopically, they invariably demonstrate continuity with the epithelium, showing do…
pubmed
Hartsough EM, Moran J, Devins K, Wszolek M 等
2023 Jan 1
置信度 0.82
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We present a patient with acute megakaryoblastic leukemia (AMKL) harboring KMT2A-MLLT3 that converted to T cell acute lymphoblastic leukemia (T-ALL) at her fourth relapse. A 4-year-old girl developed AMKL with multiple swollen lymph nodes. She exhibited severa…
pubmed
Gao L, Lu J, Li J, Hu Y 等
2023 May
置信度 0.82
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Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which we dub tran…
pubmed
Overduin M, Tran A, Eekels DM, Overduin F 等
2022 Nov 17
置信度 0.82
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Gastroblastoma is an extremely rare stomach tumor that primarily presents in adolescent and early adulthood, with a biphasic cell morphology of epithelioid and spindle cells. In light of its similarity to other childhood blastomas, it has been named gastroblas…
pubmed
Liu Y, Wu H, Wu X, Feng Y 等
2022 Nov 17
置信度 0.82
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Aneurysmal bone cyst (ABC) of the orbit is a very rare tumor, occurring mostly in the pediatric population, and can result in sight threatening complications and disfigurement. This review discusses previously reported cases with a focus on evolving treatment …
pubmed
Phan T, Tong J, Krivanek M, Graf N 等
2023 May-Jun 01
置信度 0.82
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We describe a case of a myoepithelial carcinoma of the superficial parotid gland in a 46-year-old male harboring a novel CTCF::NCOA2 gene fusion. To our knowledge, this novel gene fusion has not been described previously in myoepithelial carcinoma. A 46-year-o…
pubmed
Gandhi J, Mantilla JG, Ricciotti RW, Chen EY 等
2023 Mar
置信度 0.82
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With the growing availability of RNA sequencing technology in the pathology laboratory, new gene fusion-associated malignancies are increasingly being characterized. In this article, we describe the second ever reported case of a uterine sarcoma harboring a FG…
pubmed
Zyla RE, Goebel EA, Jang JH, Turashvili G
2022 Nov 1
置信度 0.82
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Secretory carcinoma (SC) is a recently recognized type of salivary gland tumor characterized by t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion. Most SCs are located in a main salivary gland, and primary sinonasal secretary carcinoma is…
pubmed
Yue C, Zhao X, Ma D, Piao Y
2022 Dec
置信度 0.82
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The hydrogen infrastructure involves hydrogen production, storage and delivery for utilization with clean energy applications. Hydrogen ingress into structural materials can be detrimental due to corrosion and embrittlement. To enable safe operation in applica…
pubmed
Rönnebro ECE, Oelrich RL, Gates RO
2022 Oct 2
置信度 0.82
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A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. The tumors occurred at multiple sites in the head and neck including in the sinonasal tract, mi…
pubmed
Ruangritchankul K, Sandison A
2023 Mar 1
置信度 0.82
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Secretory carcinoma (SC) is a well-established salivary gland malignancy that has earned its popularity for its unique clinicopathological behavior. Although it is an indolent malignancy, few of them have been reported with high grade transformation making it …
pubmed
Sharma P, Sivakumar N, Pandiar D
2023 Mar
置信度 0.82
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Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a number of conditions including osteoporosis where suppression of bone resorption is desired. However, denosumab discontinuation is associate…
pubmed
Kim AS, Girgis CM, McDonald MM
2022 Dec
置信度 0.82
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Adamantinoma-like Ewing sarcoma (ALES) is a histological subtype of Ewing sarcoma that demonstrates the morphological and immunohistochemical features of the latter, harbors the EWSR1::FLI1 gene fusion, and additionally demonstrates complex epithelial differen…
pubmed
Kakkar A, Bharati V, Pulimala S, Kumar R 等
2023 Jan
置信度 0.82
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Mitochondria are dynamic organelles that undergo fusion and fission. These active processes occur continuously and simultaneously and are mediated by nuclear-DNA-encoded proteins that act on mitochondrial membranes. The balance between fusion and fission deter…
pubmed
Al Ojaimi M, Salah A, El-Hattab AW
2022 Sep 16
置信度 0.82
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Well differentiated and dedifferentiated liposarcomas (WDLPS and DDLPS) are tumors of the adipose tissue poorly responsive to conventional cytotoxic chemotherapy which currently remains the standard-of-care. The dismal prognosis of the DDLPS subtype indicates …
pubmed
Cassinelli G, Pasquali S, Lanzi C
2022
置信度 0.82
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The landscape of uterine sarcomas is becoming increasingly complex with the description of new entities associated with recurrent molecular alterations. Uterine sarcomas, as well as soft tissue sarcomas, can be distinguished into complex genomic sarcomas and s…
pubmed
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I 等
2022 Nov
置信度 0.82
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Acute promyelocytic leukemia (APL) is associated with severe coagulopathy leading to rapid morbidity and mortality if left untreated. The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This…
pubmed
Korsos V, Miller WH Jr
2022 Nov 1
置信度 0.82
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Selpercatinib, a highly selective and potent REarranged during Transfection (RET) kinase inhibitor, is effective in advanced RET -altered thyroid cancer (TC). However, the efficacy and safety in Chinese patients are unknown.
pubmed
Zheng X, Ji Q, Sun Y, Ge M 等
2022
置信度 0.82
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NUT carcinoma (NC) is a rare subtype of squamous cell carcinoma defined by NUTM1 rearrangements encoding NUT fusion oncoproteins (the most frequent fusion partner being BRD4 ) that carries a very poor prognosis, with most patients dying in under 1 year. Only r…
pubmed
Barletta JA, Gilday SD, Afkhami M, Bell D 等
2022 Dec 1
置信度 0.82
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Tamoxifen (TAM) is the most prescribed selective estrogen receptor modulator (SERM) to treat hormone-receptor-positive breast cancer patients and has been used for more than 20 years. Its role as a hormone therapy is well established; however, the potential ro…
pubmed
Mohd Idris RA, Mussa A, Ahmad S, Al-Hatamleh MAI 等
2022 Aug 17
置信度 0.82
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During sexual reproduction in the unicellular green alga Chlamydomonas, gametes undergo the conserved cellular events that define fertilization across the tree of life. After initial ciliary adhesion, plus and minus gametes attach to each other at plasma membr…
pubmed
Snell WJ
2022 Oct
置信度 0.82
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Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 males and 61 females with median age 68 years. Most tumors involved the nasal cavity …
pubmed
Chłopek M, Lasota J, Thompson LDR, Szczepaniak M 等
2022 Nov
置信度 0.82
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Secretory carcinoma (SC) is a rare form of salivary carcinoma that was first described in 2010 and is characterized by ETV6::NTRK3 fusion in most cases. In this large retrospective study, we aimed to identify adverse clinicopathologic factors and propose a pro…
pubmed
Xu B, Viswanathan K, Umrau K, Al-Ameri TAD 等
2022 Nov
置信度 0.82
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Since the approval of neurotrophic tropomyosin receptor kinase (NTRK) tyrosine kinase inhibitors for fist-line advanced stage pan-cancer therapy, pathologists and molecular biologists have been facing a complex question: how should the large volume of specimen…
pubmed
Hondelink LM, Schrader AMR, Asri Aghmuni G, Solleveld-Westerink N 等
2022 Sep
置信度 0.82
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The SET-CAN/NUP214 fusion gene resulting from chromosomal del(9)(q34.11q34.13) or t(9;9) (q34;q34) has been found in T-cell acute lymphoblastic leukemia (T-ALL), B-cell acute lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML) and myeloid sarcoma (MS)…
pubmed
Wang J, Zhan QR, Lu XX, Zhang LJ 等
2022 Jul 29
置信度 0.82
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Background: Noninvasive encapsulated follicular variant papillary thyroid carcinoma (EFVPTC) was reclassified as "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) in 2016. Most existing studies that examined outcomes includ…
pubmed
Taneja C, Yip L, Morariu EM, Seethala R 等
2022 Nov
置信度 0.82
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Genome editing continues to revolutionize biological research. Due to its simplicity and flexibility, CRISPR/Cas-based editing has become the preferred technology in most systems. Cas nucleases tolerate fusion to large protein domains, thus allowing combinatio…
pubmed
Tan J, Forner J, Karcher D, Bock R
2022 Nov
置信度 0.82
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Nystagmus has been reported in up to 30% of people with Down Syndrome (DS), and yet is still not well understood. Our study aims to characterise the clinical features of patients with DS and nystagmus.
pubmed
Oladiwura D, Shweikh Y, Roberts C, Theodorou M
2022
置信度 0.82
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Primary extraskeletal myxoid chondrosarcoma (pEMC) of the breast is rare and only a few cases have been reported to date. Herein, we report a case of primary EMC of the breast in a 45-year-old female. The patient presented with a left breast mass for 1 month. …
pubmed
Sharma S, Lobo A, Sharma A, Sampat NY 等
2022 Jun
置信度 0.82
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Influenza A virus (IAV) has caused recurrent epidemics and severe pandemics. In this study, we adapted an MS2-MCP live-cell imaging system to visualize IAV replication. A reporter plasmid, pHH-PB2-vMSL, was constructed by replacing a part of the PB2-coding seq…
pubmed
Chiu YF, Huang YW, Chen CY, Chen YC 等
2022
置信度 0.82
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Structural imaging remains an essential component of diagnosis, staging and response assessment in patients with cancer; however, as clinicians increasingly seek to noninvasively investigate tumour phenotypes and evaluate functional and molecular responses to …
pubmed
Bodei L, Herrmann K, Schöder H, Scott AM 等
2022 Aug
置信度 0.82
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A solitary fibrous tumor (SFT) is a ubiquitous tumor that occurs across all ages. It is rarely reported in pediatric patients, especially as a congenital mass. A 1 year 7-month old male child presented with a slow-growing gluteal mass since birth along with a …
pubmed
Rao V, Rekhi B, Abraham LK, Bapat P
2023 May
置信度 0.82
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The effects of androgens have been extensively studied in a variety of organs and cell types with an increasing focus on the sexually dimorphic role androgens play not only with respect to cellular functions but also in metabolism. Although the classical mecha…
pubmed
Ahmad I, Newell-Fugate AE
2022 Sep 1
置信度 0.82
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236 U is an anthropogenic radionuclide that is produced from nuclear reactions of 235 U(n, γ) and 238 U(n, 3n). It has gained extensive attention in the field of environment, geology, nuclear emergency, and nuclear forensics. Due to the unique physical a…
pubmed
Shao Y, Zhang J, Luo M, Xu D 等
2022 Oct
置信度 0.82
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Acute promyelocytic leukemia (APL) constitutes a serious hematological emergency necessitating rapid diagnosis and therapy to prevent lethal bleedings resulting from APL-induced thrombocytopenia and coagulopathy. Atypical manifestations of APL, such as extrame…
pubmed
Harrer DC, Lüke F, Einspieler I, Menhart K 等
2022
置信度 0.82
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Poromas, and their malignant counterparts, porocarcinomas, harbor recurrent translocations involving YAP1-MAML2, YAP1-NUTM1, and infrequently WWTR1-NUTM1; YAP1-NUTM1 being the most common in porocarcinomas. NUT immunohistochemistry (IHC) can be used to identif…
pubmed
Snow JT, Georgantzoglou N, Green DC, Parra O 等
2022 Oct
置信度 0.82
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The landscape of somatic mutations in prostate cancer (PCa) has quickly evolved over the past years.
pubmed
Cotter K, Rubin MA
2022 Aug
置信度 0.82
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Failure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerate or repla…
pubmed
Carotenuto F, Politi S, Ul Haq A, De Matteis F 等
2022 May 16
置信度 0.82
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Aberrant mitochondrial phenotypes are common to many central nervous system (CNS) disorders, including neurodegenerative and neurodevelopmental diseases. Mitochondrial function and homeostasis depend on proper control of several biological processes such as ch…
pubmed
Gasparotto M, Lee YS, Palazzi A, Vacca M 等
2022 Apr 23
置信度 0.82
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Triplication of genes encoded in human chromosome 21 (HSA21) is responsible for the phenotypes of Down syndrome (DS). The dosage-imbalance of the nuclear genes and the extra-nuclear mitochondrial DNA (mtDNA) jointly contributes to patho-mechanisms in DS. The m…
pubmed
Ganguly BB, Kadam NN
2022 Jul
置信度 0.82
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Low-dose radiotherapy (LD-RT) is a local treatment option for patients with chronic degenerative and inflammatory diseases, in particular musculoskeletal diseases. Despite reported analgesic and anti-inflammatory effects, cellular and molecular mechanisms rela…
pubmed
Eckert D, Rapp F, Tsedeke AT, Kraft D 等
2022
置信度 0.82
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Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500-1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells. Thanks to advances in structural anal…
pubmed
Dultz E, Wojtynek M, Medalia O, Onischenko E
2022 Apr 25
置信度 0.82
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The ETS-related gene ( ERG ) is proto-oncogene that is classified as a member of the ETS transcription factor family, which has been found to be consistently overexpressed in about half of the patients with clinically significant prostate cancer (PCa). The ove…
pubmed
Khosh Kish E, Choudhry M, Gamallat Y, Buharideen SM 等
2022 Apr 26
置信度 0.82
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Spindle cell rhabdomyosarcoma represents a rare neoplasm characterized by monomorphic spindle cells with a fascicular architecture and variable skeletal muscle differentiation. Following incidental identification of a ZFP64::NCOA3 gene fusion in an unclassifie…
pubmed
Han R, Dermawan JK, Demicco EG, Ferguson PC 等
2022 Nov
置信度 0.82
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pubmed
Vaupel P, Müller W, Piazena H, Vaupel P
2022
置信度 0.82
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Background After severe traumatic brain injury (sTBI), physicians use long-term prognostication to guide acute clinical care yet struggle to predict outcomes in comatose patients. Purpose To develop and evaluate a prognostic model combining deep learning of he…
pubmed
Pease M, Arefan D, Barber J, Yuh E 等
2022 Aug
置信度 0.82
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After the coronavirus disease-19 (COVID-19) pandemic, the definition of health continuity, well-being, and well-dying is also evolving.
pubmed
Lee J, Kwon KH
2022 Jun
置信度 0.82
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The invasiveness and high proliferation rate of growth hormone-secreting pituitary adenomas (GHPAs) are closely related to poor prognosis in patients. We previously reported that abnormal glycolysis participates in this process; however, the role of mitochondr…
pubmed
Zhang Y, Zhang L, Fan K, Gou Y 等
2022
置信度 0.82
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Refractory high entropy alloys have broad application prospects due to their excellent comprehensive properties in high temperature environments, and they have been widely implemented in many complex working conditions. According to the latest research reports…
pubmed
Ren X, Li Y, Qi Y, Wang B
2022 Apr 17
置信度 0.82
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This paper reviews recent applications of Generative Adversarial Networks (GANs) in Positron Emission Tomography (PET) imaging. Recent advances in Deep Learning (DL) and GANs catalysed the research of their applications in medical imaging modalities. As a resu…
pubmed
Apostolopoulos ID, Papathanasiou ND, Apostolopoulos DJ, Panayiotakis GS
2022 Sep
置信度 0.82
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Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy. Acetylation regulates autophagy initiation…
pubmed
Xu Y, Wan W
2023 Feb
置信度 0.82
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Differentiated thyroid cancers (DTCs) in the paediatric population differ from that of their adult counterparts in terms of clinicopathological characteristics and treatment outcomes. This systematic review and meta-analysis was conducted to comprehensively ev…
pubmed
Satapathy S, Bal C
2022 Jun 27
置信度 0.82
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pubmed
Costa BA, Maraveyas A, Wilkoff MH, Correia GSC 等
2022 Jun
置信度 0.82
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Originally described in a rare subset of poorly differentiated squamous cell carcinomas termed NUT carcinomas, NUTM1 rearrangements are now known to characterize a wide spectrum of neoplasms including sarcomas, poromas/porocarcinomas, unclassified adnexal carc…
pubmed
Georgantzoglou N, Aghighi M, Cote G, Hung YP 等
2022 Dec
置信度 0.82