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pubmed
Zhang ZH, Wan W, Li LD, Dong F 等
2022 Feb 14
置信度 0.82
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Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from the midline structures of the thorax, head, and neck, and exhibits variable…
pubmed
Moreno V, Saluja K, Pina-Oviedo S
2022
置信度 0.82
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Cancer immunotherapy using monoclonal antibodies targeting immune checkpoints has undoubtedly revolutionized the cancer treatment landscape in the last decade. Immune checkpoint inhibitors can elicit long-lasting, previously unheard-of responses in a number of…
pubmed
Tschernia NP, Gulley JL
2022 Mar
置信度 0.82
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Thyroid adenoma-associated (THADA) fusions are being identified more frequently with increased preoperative molecular testing on indeterminate thyroid fine-needle aspirates (FNA). However, data on cytomorphologic features of THADA-fusion thyroid lesions are li…
pubmed
Roberts JW, Lubin DJ, Shi Q, Viswanathan K
2022 Jul
置信度 0.82
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Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare tumor that typically presents in the head, neck, and chest region. NMC is characterized by rearrangement of the NUTM1 gene. It mainly affects children and young adults and is rapidly progres…
pubmed
Saiki A, Sakamoto K, Bee Y, Izumo T
2022 May 31
置信度 0.82
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Here, we introduced the first case of acute myeloid leukemia (AML) with RARG-NUP98 in a pediatric patient. The young male presented with structural and functional abnormalities similar to hypergranular acute promyelocytic leukemia, but was resistant to all tra…
pubmed
Zhang J, Shen H, Song H, Shen D 等
2022 Apr 1
置信度 0.82
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The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55 benzodiazepines were …
pubmed
Yu J, Gou W, Shang H, Cui Y 等
2022 Dec
置信度 0.82
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Cellular reprogramming is the process during which epigenetic markers of nuclear genome are deleted and remodeled during sperm-egg binding or nuclear transplantation, thereby rendering differentiated cells totipotent. The main cellular reprogramming methods ar…
pubmed
Cui HL, Shi PH, Gao JC, Zhang XB 等
2022 Mar 20
置信度 0.82
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Degradation of material properties under neutron irradiation generates a requirement for studying effects on materials in a fusion environment and optimizing radiation-resistant materials for future applications. In the present work, the durability of stainles…
pubmed
Pandey J, Pandey B, Subhash PV, Kanth P 等
2022 Jun
置信度 0.82
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Epigenetics refers to alterations in gene expressions that are reversible and stable, but do not involve changes in DNA sequences. In recent years, an increasing number of studies have shown that epigenetics plays a critical role in autophagy, which can be sch…
pubmed
Ma T, Li A, Guo Y, Li S 等
2022 Apr
置信度 0.82
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Myoepithelial carcinoma (MEC) of soft tissue, also known as malignant myoepithelial tumor, is an uncommon malignancy. Cytologic diagnosis of this entity is challenging due to its rarity and heterogeneous morphology. We report a case of MEC in a 22-year-old man…
pubmed
Wang L, Yee-Chang M, Sun W, Melamed J 等
2022 Jul
置信度 0.82
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It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH -wild type (GBMs, IDH wt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of "chicken-wire" v…
pubmed
Broggi G, Piombino E, Altieri R, Romano C 等
2022
置信度 0.82
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Angiofibroma of soft tissue (AFST) is a new soft tissue tumor entity described in the 2020 World Health Organization Classification of Soft Tissue and Bone Tumors. It most often arises in the lower extremities of middle-aged adults and pursues a benign clinica…
pubmed
Nakayama S, Nishio J, Aoki M, Koga K 等
2022 Aug
置信度 0.82
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The debut of multimodal Single Photon Emission Computed Tomography/X-ray Computed Tomography (SPECT/CT) has signified an important advancement of Nuclear Medicine imaging by allowing for high-quality attenuation correction and co-registration/fusion of metabol…
pubmed
Ritt P
2022 May
置信度 0.82
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crossref
Guang-Hong Lu, Hong-Bo Zhou, Charlotte S. Becquart
2014-07-24T07:14:27Z
置信度 0.70
-
crossref
A. S. ROUSSETSKI
2007-11-28T07:41:36Z
置信度 0.70
-
crossref
R Vandenbosch
2002-07-27T07:45:50Z
置信度 0.70
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crossref
B.C. Odegard, B.A. Kalin
2002-07-25T18:18:56Z
置信度 0.70
-
crossref
Luis Roso
2008-08-27T12:06:31Z
置信度 0.70
-
crossref
Luis Roso
2008-08-04T04:54:46Z
置信度 0.70
-
crossref
2025-11-21T12:47:20Z
置信度 0.70
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crossref
2011-01-25T05:46:28Z
置信度 0.70
-
External constraints, such as development, disease, and environment, can induce changes in epigenomic patterns that may profoundly impact the health trajectory of fetuses and neonates into adulthood, influencing conditions like obesity. Epigenetic modification…
pubmed
Li RL, Kang S
2024 Oct 10
置信度 0.82
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Following on from the 2015 Lancet Oncology Commission on expanding global access to radiotherapy, Radiotherapy and theranostics: a Lancet Oncology Commission was created to assess the access and availability of radiotherapy to date and to address the important…
pubmed
Abdel-Wahab M, Giammarile F, Carrara M, Paez D 等
2024 Nov
置信度 0.82
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The World Health Organization Classification of Tumors of the Central Nervous System, 5th edition (WHO CNS5) significantly revised the terminology and diagnostic criteria of "mesenchymal nonmeningothelial" tumors of CNS to better align with the classification …
pubmed
Soni N, Ora M, Szekeres D, Bathla G 等
2025 May 2
置信度 0.82
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The protein menin is encoded by the MEN1 gene and primarily serves as a nuclear scaffold protein, regulating gene expression through its interaction with and regulation of chromatin modifiers and transcription factors. While the scope of menin's functions cont…
pubmed
Majer AD, Hua X, Katona BW
2024 Sep 21
置信度 0.82
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Primary secretory carcinoma (SC) of the thyroid gland is a rare neoplasm, characterized by the presence of oncogenic ETV6::NTRK3 fusions, which are amenable to tropomyosin receptor kinase (TRK) inhibitor therapy. Despite its morphologic, immunophenotypic, and …
pubmed
Chu YH, Kobrossy B, Schwartz D, Bruns AD 等
2024 Sep 22
置信度 0.82
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Nuclear protein in testis (NUT) carcinoma is a rare but highly aggressive tumor characterized by translocation of the NUTM1 gene. To date, only about 20 NUT carcinomas arising from the thyroid have been reported in the literature, with the majority showing imm…
pubmed
Suh YY, Hwang YJ, Bae JM, Koh J 等
2025 May
置信度 0.82
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With limitations of conventional imaging and biopsy, accurate, non-invasive techniques to detect clear-cell renal cell carcinoma in patients with renal masses remain an unmet need. 89 Zr-labelled monoclonal antibody ([ 89 Zr]Zr-girentuximab) has high affinity …
pubmed
Shuch B, Pantuck AJ, Bernhard JC, Morris MA 等
2024 Oct
置信度 0.82
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This study aims to analyse multiparametric MRI (mpMRI) characteristics of patients diagnosed with ISUP grade group (GG) 1 prostate cancer (PC) on initial target plus systematic MRI/TRUS fusion-guided biopsy and investigate histopathological progression during …
pubmed
Boschheidgen M, Schimmöller L, Radtke JP, Kastl R 等
2025 Apr
置信度 0.82
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Secretory carcinoma is a rare, low-grade, special histological type of invasive breast carcinoma. Although it is the most common primary breast cancer in the pediatric population, most cases are diagnosed in adults, with a median age of 48 years (range 3 to 91…
pubmed
Boustros P, Sanchez LM, Gaboury L, El Khoury M
2024 Sep 11
置信度 0.82
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In high-tech areas such as nuclear fusion, aerospace, and high-performance tools, tungsten and its alloys are indispensable due to their high melting point, low thermal expansion, and excellent mechanical properties. The rise of Additive Manufacturing (AM) tec…
pubmed
Li H, Shen Y, Wu X, Wang D 等
2024 Jul 28
置信度 0.82
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Background Lutetium 177 [ 177 Lu]Lu-PSMA-617 ( 177 Lu-PSMA-617) is a prostate-specific membrane antigen (PSMA)-targeted radioligand therapy for metastatic castration-resistant prostate cancer (mCRPC). Quantitative PSMA PET/CT analysis could provide information…
pubmed
Kuo PH, Morris MJ, Hesterman J, Kendi AT 等
2024 Aug
置信度 0.82
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Ewing sarcoma is a small round-cell sarcoma characterized by gene fusion involving EWSR1 (or another TET family protein like FUS) and an ETS family transcription factor. The estimated incidence of this rare bone tumor, which occurs most frequently in adolescen…
pubmed
Mata Fernández C, Sebio A, Orcajo Rincón J, Martín Broto J 等
2025 Mar
置信度 0.82
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Cytoplasmic male sterility (CMS) arises from the incompatibility between the nucleus and cytoplasm as typical representatives of the chimeric structures in the mitochondrial genome (mitogenome), which has been extensively applied for hybrid seed production in …
pubmed
Zhang X, Ding Z, Lou H, Han R 等
2024 Jul 31
置信度 0.82
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In patients with drug-resistant epilepsy, difficulties in identifying the epileptogenic zone are well known to correlate with poorer clinical outcomes post-surgery. The integration of PET and MRI in the presurgical assessment of pediatric patients likely impro…
pubmed
Ponisio MR, Zempel JM, Willie JT, Tomko SR 等
2024 Sep
置信度 0.82
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The endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of the cell,…
pubmed
La Torre M, Burla R, Saggio I
2024 Aug 5
置信度 0.82
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High power femtosecond laser pulses launched in air undergo nonlinear filamentary propagation, featuring a bright and thin plasma channel in air with its length much longer than the Rayleigh length of the laser beam. During this nonlinear propagation process, …
pubmed
Mei H, Jiang H, Houard A, Tikhonchuk V 等
2024 Sep 18
置信度 0.82
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The commoditization of nuclear power through the factory production of sealed micro-power units within a digitally enabled holistic assurance framework is described. This would revolutionize nuclear power-plant design, construction, operation and decommissioni…
pubmed
Patterson EA, Taylor RJ
2024
置信度 0.82
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In this report, a tumor exhibited EWSR1::RORß gene fusion, to our knowledge, is the first such reported case. The Ewing sarcoma breakpoint region 1 gene (EWSR1) is known to be associated with several soft tissue tumors although its specific role remains u…
pubmed
Park H, Banegas DW, Han SY, Kim HS 等
2024 Dec
置信度 0.82
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High-performance structural materials (HPSMs) are needed for the successful and safe design of fission and fusion reactors. Their operation is associated with unprecedented fluxes of high-energy neutrons and thermomechanical loadings. In fission reactors, HPSM…
pubmed
Luptáková N, Svoboda J, Bártková D, Weiser A 等
2024 Jul 10
置信度 0.82
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Skeletal muscle is a complex organ essential for locomotion, posture, and metabolic health. This review explores our current knowledge of Mustn1 , particularly in the development and function of skeletal muscle. Mustn1 expression originates from Pax7-positive …
pubmed
Kim CJ, Hadjiargyrou M
2024 Jun 23
置信度 0.82
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NUT carcinoma (nuclear protein in testis carcinoma) is a rare and highly invasive malignant tumor, which is most common in midline organs and lungs. The characteristic genetic change of NUT carcinoma is the rearrangement of NUT middle carcinoma family member 1…
pubmed
Du J, Zhang X
2024 Jun 20
置信度 0.82
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The nuclear pore complexes are essential for cellular and molecular processes such as trafficking between the cytoplasm and the nucleus, chromatin, transcriptional outputs, and DNA damage repair. Nucleoporins, components of nuclear pore complexes, have been li…
pubmed
Jahangiri L
2024 Aug
置信度 0.82
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The advancement of theranostics, which combines therapeutic and diagnostic capabilities in oncology, has significantly impacted cancer management. This review explores fibroblast activation protein (FAP) expression in the tumor microenvironment (TME) and its a…
pubmed
Baum RP, Novruzov E, Zhao T, Greifenstein L 等
2024 Jul
置信度 0.82
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The transformation of acute promyelocytic leukemia (APL) from the most fatal to the most curable subtype of acute myeloid leukemia (AML), with long-term survival exceeding 90%, has represented one of the most exciting successes in hematology and in oncology. A…
pubmed
Testa U, Pelosi E
2024
置信度 0.82
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Invertebrate and vertebrate species have many unusual cellular structures, such as long- or short-lived cell-in-cell structures and coenocytes. Coenocytes (often incorrectly described as syncytia) are multinuclear cells derived, unlike syncytia, not from the f…
pubmed
Kloc M
2024 Jul 9
置信度 0.82
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Nuclear protein in testis (NUT) carcinoma (NC) is a rare, highly aggressive neoplasm, usually accompanying with NUTM1 (NUT midline carcinoma family member 1) gene fusions. Primary thyroid NC is clinically rare and to date there is no established treatment guid…
pubmed
Cao J, Liu Y, Lu C
2024 Jun 30
置信度 0.82
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Exposure of metals to neutron irradiation results in an increase in the yield strength and a significant loss of ductility. Irradiation hardening is also closely related to the fracture toughness temperature shift or the ductile-to-brittle transition temperatu…
pubmed
Ma H, Fan P, Qian Q, Zhang Q 等
2024 Jul 3
置信度 0.82
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MiT family translocation renal cell carcinomas (tRCCs) primarily include Xp11.2/transcription factor E3 (TFE3) gene fusion-associated renal cell carcinoma (Xp11.2 tRCC) and t(6;11)/TFEB gene fusion-associated RCC. Clinical cases of these carcinomas are rare. F…
pubmed
Wang Y, Guo X, Meng Z, Cui Y 等
2024
置信度 0.82
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The 5th WHO classification of thoracic tumours includes thoracic SMARCA4-deficient undifferentiated tumour (SMARCA4-UT) among the "other epithelial tumours of the lung" chapter. Herein, we present a case of undifferentiated thoracic neoplasm with retention of …
pubmed
Zagni M, Marando A, Negrelli M, Lauricella C 等
2024 Jun
置信度 0.82
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Sclerosing epithelioid fibrosarcoma (SEF) and low-grade fibromyxoid sarcoma (LGFMS) constitute a morphological continuum with certain overlapping histopathological features and MUC 4 immunopositivity. SEF is characterized by EWSR1 gene rearrangement, is relati…
pubmed
Agarwal A, Rekhi B, Goel V, Bajpai J 等
2024 Oct 1
置信度 0.82
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This study aimed to analyze articles on the diagnosis and treatment of bone and soft tissue sarcoma using positron emission tomography (PET)/computed tomography (CT) published in the last 13 years. The objective was to conduct a bibliometric analysis and ident…
pubmed
Xiang F, Zhang Y, Tan X, Zhang J 等
2024
置信度 0.82
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Introduction: Prostate Specific Membrane Antigen Positron Emission Tomography (PSMA-PET) is routinely used for the staging of patients with prostate cancer, but data on response assessment are sparse and primarily stem from metastatic castration-resistant pros…
pubmed
Küper AT, Kersting D, Telli T, Herrmann K 等
2024
置信度 0.82
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Specialized chemicals are used for intensifying food production, including boosting meat and crop yields. Among the applied formulations, antibiotics and pesticides pose a severe threat to the natural balance of the ecosystem, as they either contribute to the …
pubmed
Cyganowski P, Terefinko D, Motyka-Pomagruk A, Babinska-Wensierska W 等
2024 Jun 19
置信度 0.82
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Sex-specific morphogenesis occurs in Caenorhabditis elegans in the vulva of the hermaphrodite and in the male tail during the last larval stage. Temporal progression of vulva morphogenesis has been described in fine detail. However, a similar precise descripti…
pubmed
Kiontke K, Fernandez P, Woronik A, Fitch DHA
2024 Dec
置信度 0.82
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Well-developed [Formula: see text] clusters are known to exist in light [Formula: see text] nuclei, and their properties are reasonably well described with modern nuclear structure theories. However, 'modestly' developed clusters in medium to heavy nuclei rema…
pubmed
Uesaka T, Itagaki N
2024 Jul 23
置信度 0.82
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To provide practice guideline/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor (SSTR) ligands.
pubmed
Albert NL, Preusser M, Traub-Weidinger T, Tolboom N 等
2024 Oct
置信度 0.82
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Chromosomal translocations of the nucleoporin 98 (NUP98) gene are found in acute myeloid leukemia (AML) patients leading to very poor outcomes. The oncogenic activity of NUP98 fusion proteins is dependent on the interaction between Mixed Lineage Leukemia 1 and…
pubmed
Miao H, Chen D, Ropa J, Purohit T 等
2024 Aug
置信度 0.82
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Open access to three-dimensional atomic-level biostructure information from the Protein Data Bank (PDB) facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019-2023. Anal…
pubmed
Burley SK, Wu-Wu A, Dutta S, Ganesan S 等
2024 Jul
置信度 0.82
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Tumors morphologically classified as pigmented epithelioid melanocytomas (PEMs) are genomically diverse, with the 2 most common genomic subtypes being PRKC fusions or PRKAR1A inactivating mutations. PRKC fusions activate the Gα q/11 pathway similar to bl…
pubmed
Patel P, Chen A, Sharma N, Zhang Y 等
2024 Nov 1
置信度 0.82
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NUT Carcinoma（NC） is a rare malignant tumor of unknown origin, which is highly aggressive. It is characterized by chromosome rearrangement accompanied by NUTM1 gene. The pathological manifestations were sudden and focal squamous in poorly differe…
pubmed
Wang Y, Zhao J, Zhou X, Liu J
2024 Jun
置信度 0.82
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CIC-rearranged sarcomas (CRS) represent a new entity of undifferentiated small round cell sarcoma belonging to the Ewing-like sarcomas family. CRS are the most common type. Fusion partners for the CIC gene include DUX4, FOXO4, and the recently recognizedNUTM1.…
pubmed
Zhao L, He H, Ren J, Huang Y 等
2024 Jun 8
置信度 0.82
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The 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS5), introduced significant changes, impacting tumors ranging from glial to ependymal neoplasms. Ependymal tumors were previously classified and graded based on histop…
pubmed
Soni N, Ora M, Bathla G, Desai A 等
2024 Nov 7
置信度 0.82
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Pleuropulmonary blastoma (PPB) is a very rare tumor of the chest seen predominantly in young children with great heterogeneity and clinical, biochemical, and biological complexity and recognized, described, and classified as distinct from the pulmonary blastom…
pubmed
Petrovic DJ, Pavicevic P
2024 Dec
置信度 0.82
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The VERIFY study aimed to determine the efficacy of vandetanib in patients with differentiated thyroid cancer (DTC) that is either locally advanced or metastatic and refractory to radioiodine (RAI) therapy. Specifically, VERIFY is a randomized, double-blind, m…
pubmed
Brose MS, Capdevila J, Elisei R, Bastholt L 等
2024 Aug 1
置信度 0.82
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Theranostics has become a major area of innovation and progress in cancer care over the last decade. In view of the introduction of approved therapeutics in neuroendocrine tumours and prostate cancer in the last 10 years, the ability to provide access to these…
pubmed
Giammarile F, Paez D, Zimmermann R, Cutler CS 等
2024 Jun
置信度 0.82
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Although the promise of radionuclides for the diagnosis and treatment of disease was recognised soon after the discovery of radioactivity in the late 19th century, the systematic use of radionuclides in medicine only gradually increased over the subsequent hun…
pubmed
Scott AM, Zeglis BM, Lapi SE, Scott PJH 等
2024 Jun
置信度 0.82
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This paper is the first of a Series on theranostics that summarises the current landscape of the radiopharmaceutical sciences as they pertain to oncology. In this Series paper, we describe exciting developments in radiochemistry and the production of radionucl…
pubmed
Lapi SE, Scott PJH, Scott AM, Windhorst AD 等
2024 Jun
置信度 0.82
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pubmed
Settelmeier S, Kessler L, Varasteh Z, Mahabadi AA 等
2024 Jul
置信度 0.82
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Fusion energy investigation has stepped to a new stage adopting deuterium and tritium as fuels from the previous stage concentrating hydrogen plasma physics. Special radiation safety issues would be introduced during this stage. In addition to industrial and m…
pubmed
Wang Y, Nie B, Zheng S, Wu H 等
2024 Jun
置信度 0.82
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Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed by normal prostatic tissue. Therefore, molecular imaging targeting PSMA (PSMA-PET) has gained particular interest and diffusion for PCa staging and restaging. Several factors may af…
pubmed
Droghetti M, Bianchi L, Presutti M, Vetrone L 等
2024
置信度 0.82
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Biomolecular condensates, the membraneless cellular compartments formed by liquid-liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these condensa…
pubmed
Kiang KM, Ahad L, Zhong X, Lu QR
2024 Jul
置信度 0.82
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Mammalian oocyte activation is a critical process occurring post-gamete fusion, marked by a sequence of cellular events initiated by an upsurge in intracellular Ca 2+ . This surge in calcium orchestrates the activation/deactivation of specific kinases, leading…
pubmed
Bellido-Quispe DK, Arcce IML, Pinzón-Osorio CA, Campos VF 等
2024 Jul
置信度 0.82
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Traditionally, tenderness has been assessed through shear force testing, which is inherently destructive, the accuracy is easily affected, and it results in considerable sample wastage. Although this technology has some drawbacks, it is still the most effectiv…
pubmed
Li Y, Wang H, Yang Z, Wang X 等
2024 May 13
置信度 0.82
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Management strategies for metastatic castration-resistant prostate cancer (mCRPC) have rapidly shifted in recent years. As novel imaging and therapeutic approaches have made their way to the clinic, providers are encountering increasingly challenging clinical …
pubmed
Bryce AH, Crawford ED, Agarwal N, Hussain MH 等
2024 Apr
置信度 0.82
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Castration-sensitive prostate cancer (CSPC) is a complex and heterogeneous condition encompassing a range of clinical presentations. As new approaches have expanded management options, clinicians are left with myriad questions and controversies regarding the o…
pubmed
Crawford ED, Bryce AH, Hussain MH, Agarwal N 等
2024 Apr
置信度 0.82
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The first line of defense against viral infection of the host cell is the cellular lipid membrane, which is also a crucial first site of contact for viruses. Lipids may sometimes be used as viral receptors by viruses. For effective infection, viruses significa…
pubmed
Muzammil K, Sabah Ghnim Z, Saeed Gataa I, Fawzi Al-Hussainy A 等
2024 Jun
置信度 0.82
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Ewing's sarcoma (ES) is an aggressive cancer of bone and soft tissue, most of which tend to occur in the bone. Extraosseous Ewing's sarcoma (EES) of the cervix is extremely rare.
pubmed
Xiao Y, Zhi Y, Cao G, Ma H 等
2024 May 21
置信度 0.82
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Horseshoe kidney is the most common renal fusion anomaly and is associated with various complications, ranging from infections to neoplasms. While renal cell carcinoma (RCC) is the most frequent renal neoplasm in adults, its occurrence in a horseshoe…
pubmed
Ratnaparkhi C, Dhok A, Kumar N, Pande S 等
2024 Apr
置信度 0.82
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We describe a case of a pleomorphic adenoma (PA) arising from the para-tracheal accessory salivary gland in a 44-year-old male harboring a novel WWTR1::NCOA2 gene fusion. To our knowledge, this novel gene fusion has not been described previously in salivary gl…
pubmed
Alsugair Z, Pissaloux D, Descotes F, Tirode F 等
2024 May
置信度 0.82
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WHO Classification of Skin Tumors, fifth edition (2023) has newly described primary cutaneous NUT carcinoma; however, information on this cancer type remains scarce. Herein, we performed clinicopathologic and genetic analyses of 4 cases. Four elderly women (me…
pubmed
Goto K, Kukita Y, Hishima T, Matsushita S 等
2024 Aug 1
置信度 0.82
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Ewing sarcoma is an uncommon neoplasm considered in the differential diagnosis of tumors with "small round cell" morphology, but its occurrence in the gynecologic tract has only been sporadically documented. Herein, we describe the largest cohort of Ewing sarc…
pubmed
Sharma AE, Wepy CB, Chapel DB, Maccio L 等
2024 Aug 1
置信度 0.82
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The three subfamilies of herpesviruses (alphaherpesviruses, betaherpesviruses, and gammaherpesviruses) appear to share a unique mechanism for the maturation and egress of virions, mediated by several budding and fusion processes of various organelle membranes …
pubmed
Nanbo A
2024 Apr 17
置信度 0.82
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NUT carcinoma (NC) is a highly aggressive, poorly differentiated carcinoma that harbors a t(15:19) translocation, leading to the fusion of the NUTM1 gene. While the upper aerodigestive tract along the midline (head, neck, thorax, and mediastinum) is commonly r…
pubmed
Li CY, Salihoglu S, Civantos FJ, Velez Torres JM
2024 Sep
置信度 0.82
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Human cells possess many different polymerase enzymes, which collaborate in conducting DNA replication and genome maintenance to ensure faithful duplication of genetic material. Each polymerase performs a specialized role, together providing a balance of accur…
pubmed
Bainbridge LJ, Daigaku Y
2024 Jul
置信度 0.82
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Alveolar soft part sarcoma is a rare tumour of soft tissues, mostly localized in muscles or deep soft tissues of the extremities. In rare occasions, this tumour develops in deep tissues of the abdomen or pelvis.
pubmed
Guérin R, Menard AL, Angot E, Piton N 等
2024 Apr 20
置信度 0.82
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, with proto-oncogene, receptor tyrosine kinase ( c-kit ), or PDGFRα mutations detected in around 85% of cases. GISTs without c-kit or platelet-de…
pubmed
Machado I, Claramunt-Alonso R, Lavernia J, Romero I 等
2024 Mar 26
置信度 0.82
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Both aging and neurodegenerative illnesses are thought to be influenced by mitochondrial malfunction and free radical formation. Deformities of the energy metabolism, mitochondrial genome polymorphisms, nuclear DNA genetic abnormalities associated with mitocho…
pubmed
Wal P, Wal A, Vig H, Mahmood D 等
2024 Mar
置信度 0.82
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Prostate cancer is the most common cancer in men in 112 countries, and accounts for 15% of cancers. In this Commission, we report projections of prostate cancer cases in 2040 on the basis of data for demographic changes worldwide and rising life expectancy. Ou…
pubmed
James ND, Tannock I, N'Dow J, Feng F 等
2024 Apr 27
置信度 0.82
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Gene fusions with translocations involving nuclear receptor coactivators (NCoAs) are relatively common among fusion-driven malignancies. NCoAs are essential mediators of environmental cues and can modulate the transcription of downstream target genes upon bind…
pubmed
Segovia D, Tepes PS
2024 May
置信度 0.82
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Mitochondria are essential cellular organelles; detecting mitochondrial damage is crucial in cellular biology and toxicology. Compared with existing chemical probe detection methods, genetically encoded fluorescent protein sensors can directly indicate cellula…
pubmed
Liu Q, Wang D, Cui M, Li M 等
2024 May 21
置信度 0.82
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Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated. The immune system regulates the functioning of cellular metabolis…
pubmed
Ferreira C, Vieira P, Sá H, Malva J 等
2024
置信度 0.82
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As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA damag…
pubmed
Lu Y, Zhao M, Chen L, Wang Y 等
2024
置信度 0.82
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A 50-year-old male presented with neck and shoulder pain. Chest CT and 18 F-FDG PET/CT revealed osteolytic bone destruction in the left first rib and thoracic vertebrae with increased FDG uptake. Rib biopsy pathology indicated desmoplastic small round cell tum…
pubmed
Zhang H, Dai S
2024 Dec
置信度 0.82
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Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)/retinoic acid receptor α (RARA) fusion oncoprotein. Over the years, it has emerged as a model system to understand how this simple (and sometimes sole) genetic alteration ca…
pubmed
Rérolle D, Wu HC, de Thé H
2024 Sep 3
置信度 0.82
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Molecularly defined neoplasms are increasingly recognized, given the broader application and performance of molecular studies. These studies allow us to better characterize these neoplasms and learn about their pathogenesis. In the thorax, molecularly defined …
pubmed
Roden AC
2024 Sep 1
置信度 0.82
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Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Myocardial fibrosis plays an important role in adverse outcomes such as heart failure and arrhythmias. As the pathological response and degree of scarring, and therefore clinical…
pubmed
Telli T, Hosseini A, Settelmeier S, Kersting D 等
2024 Sep
置信度 0.82
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Radiotheranostics, a combination of diagnostic and therapeutic approaches, was first utilized in cancer management using radiopharmaceuticals to both image and selectively treat specific cancer subtypes nearly a century ago. Radiotheranostic strategies rooted …
pubmed
Al-Ibraheem A, Zimmermann R, Abdlkadir AS, Herrmann K
2024 Jul
置信度 0.82
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Malignant giant cell tumor of bone (GCTB) is identified by the presence of multinucleated giant cells, with an aggressive behavior and a high risk of metastasis, which has not been genetically characterized in detail. H3 histone family member 3A ( H3F3A ) gene…
pubmed
Tsuda Y, Okajima K, Ishibashi Y, Zhang L 等
2024 Mar-Apr
置信度 0.82