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• Edge Localized Mode control by Resonant Magnetic Perturbations in tokamak plasmas
  Dans les tokamaks, les instabilités nommées ELMs (pour ``Edge Localized Modes'') génèrent des relaxations quasi-périodiques du plasma, potentiellement néfastes pour le divertor d'ITER. Une méthode de contrôle des ELMs prévue pour ITER est l'application de Pert…
  crossref Francois Orain 2026-03-31T17:46:42Z 置信度 0.70
• System studies for quasi-steady-state advanced physics tokamak
  crossref R.L. Reid, Y.K.M. Peng 2009-12-12T06:00:13Z 置信度 0.70
• MHD stability of vertically asymmetric tokamak equilibria
  crossref H.E. Dalhed, R.C. Grimm, J.L. Johnson 2011-02-23T13:56:53Z 置信度 0.70
• Simulation of a compact ignition tokamak discharge (CIT-2L)
  crossref D.P. Stotler, G. Bateman 2011-02-23T19:08:08Z 置信度 0.70
• STARFIRE: a commercial tokamak fusion power plant study
  crossref 2014-05-27T22:32:55Z 置信度 0.70
• PLASMA-WALL INTERACTIONS
  crossref Rainer Behrisch 2013-11-20T10:17:12Z 置信度 0.70
• Two-dimensional transport of tokamak plasmas. [Neoclassical transport theory]
  crossref S.P. Hirshman, S.C. Jardin 2011-02-23T19:00:59Z 置信度 0.70
• Time evolution of mass flows in a collisional tokamak
  crossref A.B. Hassam, R.M. Kulsrud 2011-02-23T19:21:45Z 置信度 0.70
• UWMAK-III, a noncircular tokamak power reactor design
  crossref R. Conn, G. Kulcinski 2020-09-26T06:38:50Z 置信度 0.70
• Linear Ideal Modes
  crossref R.B. White 2013-11-18T09:52:56Z 置信度 0.70
• Steady-State Superconducting Advanced Spherical Tokamak Reactor (Sastr)
  crossref Yoshio Nagayama, Takaaki Fujita 2024-11-16T18:37:42Z 置信度 0.70
• Global properties of high pressure flux conserving tokamak equilibria
  crossref J.F. Clarke, D.J. Sigmar 2013-08-01T03:36:05Z 置信度 0.70
• Tokamak experimental power reactor conceptual design. Volume II
  crossref 2013-12-09T22:33:52Z 置信度 0.70
• Tokamak poloidal field systems. Progress report, January 1-December 31, 1979
  crossref J.D. Rogers 2008-09-04T04:11:04Z 置信度 0.70
• Diagnostic applications of transient synchrotron radiation in tokamak plasmas
  crossref N.J. Fisch, A.H. Kritz 2011-02-23T14:30:38Z 置信度 0.70
• Tokamak currents driven by weak electrostatic waves
  crossref D A Hitchcock, S M Mahajan 2014-06-16T22:58:34Z 置信度 0.70
• Tokamak experimental power reactor conceptual design. Volume I
  crossref 2009-04-08T08:49:34Z 置信度 0.70
• UWMAK-III, a noncircular tokamak power reactor design
  crossref R. Conn, G. Kulcinski 2020-09-26T06:38:51Z 置信度 0.70
• Evaluation of potential runaway generation in large-tokamak disruptions
  crossref H.H. Fleischmann, S.J. Zweben 2008-02-06T04:36:41Z 置信度 0.70
• Nuclear aspects of tokamak fusion test reactor (TFTR) diagnostics and instrumentation
  crossref K.M. Young 2011-02-23T18:08:57Z 置信度 0.70
• Plasma transport in a compact ignition tokamak
  crossref C.E. Singer, L.P Ku, G. Bateman 2011-02-23T19:10:29Z 置信度 0.70
• Tokamak reactor systems studies
  crossref 2008-02-06T05:29:25Z 置信度 0.70
• Development of a free-boundary tokamak equilibrium solver for advanced study of tokamak equilibria
  crossref Young Mu Jeon 2015-09-18T06:17:00Z 置信度 0.70
• Guiding Center Motion
  crossref R.B. White 2013-11-18T09:52:56Z 置信度 0.70
• Linear optimal control of tokamak fusion devices
  crossref C.E. Kessel, M.A. Firestone, R.W. Conn 2011-02-23T18:41:17Z 置信度 0.70
• Phase Integral Methods
  crossref R.B. White 2013-11-18T09:53:41Z 置信度 0.70
• Tokamak poloidal-field systems. Progress report, January 1-December 31, 1981
  crossref J.D. Rogers 2008-09-04T01:03:44Z 置信度 0.70
• A method for determining poloidal coil configurations for tokamak devices
  crossref K. Jr. Evans 2008-08-16T04:55:27Z 置信度 0.70
• How Zonal Fields Suppress Reversed Shear Alfvén Eigenmode in Tokamak Plasmas.
  europepmc 2026 置信度 0.80
• Impact of ECRH on Runaway Electron Generation during Plasma Disruptions in the HL-3 Tokamak
  Abstract This work investigates the impact of Electron Cyclotron Resonance Heating (ECRH) on runaway electron (RE) generation during MGI-triggered disruptions on the HL-3 tokamak. During these disruptions, a large RE current is formed, primarily through the ho…
  europepmc Apiwat Wisitsorasak, Kitti Rongpuit, Siriyaporn Sangaroon, Yipo Zhang 等 2026 置信度 0.80
• Tokamak level performance in the optimized stellarator Wendelstein 7-X with stable peaked density profiles.
  europepmc 2026 置信度 0.80
• Strategies for identifying NUP98 rearrangements in adult myeloid neoplasms.
  Nucleoporin 98 rearrangements (NUP98r) are recurrent in myeloid neoplasms and are subtype-defining for acute myeloid leukemia (AML) in the World Health Organization Classification 5th edition (WHO5) and the International Consensus Classification (ICC). Identif…
  pubmed Yuen LD, Hasserjian RP, Fathi AT, Luskin MR 等 2026 Feb 1 置信度 0.82
• Reasonable Design of Near-Infrared Boron Dipyrromethene with Cationic Pyridinium for Super-Resolution Imaging of Dynamic Voltages of Mitochondria in Living Cells.
  Mitochondrial membrane potential (ΔΨ m ) is a critical regulator of cellular homeostasis and an established biomarker in mitochondrial dysfunction. While super-resolution fluorescence imaging reveals intrinsic links between mitochondrial ultrastruc…
  pubmed Wang JL, Zhang L, He H, Zhang P 等 2025 Sep 26 置信度 0.82
• Transcriptionally up-regulation of CDKN1A/p21 by TFE3 fusion proteins worsened TFE3-rearranged renal cell carcinoma.
  The TFE3-rearranged renal cell carcinoma (TFE3-rRCC), which is an uncommon and aggressive form of kidney cancer, has an unfavorable prognosis. It has been shown that CDKN1A/p21 is high-expressed in TFE3-rRCC, however, the exact mechanism and the role of CDKN1A…
  pubmed Lu Y, Ma W, Chen Y, Dong X 等 2025 Aug 17 置信度 0.82
• Primary pulmonary spindle cell sarcoma with novel MBNL2::NUTM1 fusion and associated langerhans cell hyperplasia.
  NUTM1-rearranged sarcomas are rare, genetically diverse tumors with variable histologic features and fusion partners. Their diagnosis remains challenging, especially in low-grade or unusual presentations. We describe the first reported case of a pulmonary spin…
  pubmed Wu J, Li M, Zhao D, Liu Y 等 2025 Oct 置信度 0.82
• Tumor-specific PET tracer imaging and contrast-enhanced Mri based tumor volume differences inspection of glioblastoma patients.
  Despite advancements in treatment strategies, glioblastoma, also known as GBM, remains an exceptionally aggressive primary brain tumor with a grim prognosis. Despite innovations in treatment strategies, GBM continues to pose significant challenges. The assessm…
  pubmed Abbasi IA, Alshehri M, AlQahtani Y 2025 Aug 16 置信度 0.82
• Preoperative ternary classification using DCE-MRI radiomics and machine learning for HCC, ICC, and HIPT.
  This study develops a machine learning model using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics and clinical data to preoperatively differentiate hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and hepatic inf…
  pubmed Xie P, Liao ZJ, Xie L, Zhong J 等 2025 Aug 14 置信度 0.82
• GLI1/2-altered mesenchymal tumors: a study of 8 cases expanding the clinicopathological and molecular spectrum including an upstream PTCH1-inactivating mutation.
  GLI1/2 alterations drive mesenchymal tumors harboring rearrangements and amplifications. Affected patients show a broad age range and tumor distribution, and histology varies. We describe the clinicopathologic and molecular characteristics of eight cases (7 fe…
  pubmed Hiemcke-Jiwa LS, van Ewijk R, van Noesel MM, Tops BBJ 等 2025 Oct 置信度 0.82
• Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease.
  Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are two common liver disorders characterized by abnormal lipid accumulation. Our study found reduced levels of GTPase-activating protei…
  pubmed Ouyang Q, Su J, Li Y, Liao H 等 2025 Aug 14 置信度 0.82
• Predicting microRNA-Disease Associations Through Multi-View Feature Fusion and Matrix Completion on Graph Convolutional Networks.
  Since the regulatory roles of microRNAs in complex human diseases have been gradually demonstrated, more and more enlightening models were developed for predicting microRNA-disease associations. These models can inform bio-logical studies on the differential e…
  pubmed Ding S, Cao C, Sun F, Li X 等 2025 Jan-Feb 置信度 0.82
• Alpha-Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models.
  Cancer-associated cachexia (CAC) is a multifactorial syndrome characterised by progressive loss of muscle mass with limited Food and Drug Administration treatments. Although emerging evidence suggests that l-leucine and β-hydroxy-β-methyl butyrate …
  pubmed Lim P, Woo SW, Han J, Lee YL 等 2025 Aug 置信度 0.82
• Toti-N-glycan Recognition Enables Universal Multiplexed Single-Nucleus RNA Sequencing.
  Sample barcoding-based multiplex single-cell and single-nucleus sequencing (sc/sn-seq) offers substantial advantages by reducing costs, minimizing batch effects, and identifying artifacts, thereby advancing biological and biomedical research. Despite these ben…
  pubmed Guo Y, Zhang L, Zhao X, Xu C 等 2025 置信度 0.82
• Replication program of a single-chromosome budding yeast strain.
  Nuclear architecture and chromosome folding are often speculated to influence genome replication. In yeasts, centromeres cluster close to the spindle pole body and telomeres position at the nuclear periphery. This 'Rabl configuration' spatially segregates the …
  pubmed Pellet J, Lacroix L, Theulot B, Simonin Chavignier E 等 2025 Aug 11 置信度 0.82
• The Influence of Print Orientation and Discontinuous Carbon Fiber Content on the Tensile Properties of Selective Laser-Sintered Polyamide 12.
  Discontinuous fibers are commonly added to matrix materials in additive manufacturing to enhance properties, but such benefits may be constrained by print and fiber orientation. The additive processes of forming rasters and layers in powder bed fusion inherent…
  pubmed Slager JJ, Green JT, Levine SD, Gonzalez RV 2025 Jul 25 置信度 0.82
• Attention-Guided Residual Spatiotemporal Network with Label Regularization for Fault Diagnosis with Small Samples.
  Fault diagnosis is of great significance for the maintenance of rotating machinery. Deep learning is an intelligent diagnostic technique that is receiving increasing attention. To address the issues of industrial data with small samples and varying working con…
  pubmed Xu Y, Zhang L, Chen L, Tan T 等 2025 Aug 3 置信度 0.82
• Geographical Origin Authentication of Leaves and Drupes from Olea europaea via (1)H NMR and Excitation-Emission Fluorescence Spectroscopy: A Data Fusion Approach.
  Geographical origin authentication of agrifood products is essential for ensuring their quality, preventing fraud, and maintaining consumers' trust. In this study, we used proton nuclear magnetic resonance ( 1 H NMR) and excitation-emission matrix (EEM) fluore…
  pubmed Tatini D, Bisozzi F, Costantini S, Fattori G 等 2025 Jul 30 置信度 0.82
• GNR: Genetic-Embedded Nuclear Reaction Optimization with F-Score Filter for Gene Selection in Cancer Classification.
  The classification of cancer based on gene expression profiles is a central challenge in precision oncology due to the high dimensionality and low sample size inherent in microarray datasets. Effective gene selection is crucial for improving classification acc…
  pubmed Alkamli S, Alshamlan H 2025 Aug 6 置信度 0.82
• Chromosomal Deletion Involving ANKRD26 Leads to Expression of a Fusion Protein Responsible for ANKRD26-Related Thrombocytopenia.
  ANKRD26-related thrombocytopenia (ANKRD26-RT) is characterized by lifelong mild to moderate thrombocytopenia. Patients suffer from an increased susceptibility to acute or chronic myeloid leukemia, myelodysplastic syndrome, or chronic lymphocytic leukemia. We d…
  pubmed Dell'Orso G, Passarella T, Cappato S, Cappelli E 等 2025 Jul 29 置信度 0.82
• X-UNet:A novel global context-aware collaborative fusion U-shaped network with progressive feature fusion of codec for medical image segmentation.
  Due to the inductive bias of convolutions, CNNs perform hierarchical feature extraction efficiently in the field of medical image segmentation. However, the local correlation assumption of inductive bias limits the ability of convolutions to focus on global in…
  pubmed Xu S, Chen Y, Zhang X, Sun F 等 2025 Dec 置信度 0.82
• Diagnostic Pitfalls of TFE3-Rearranged Perivascular Epithelioid Cell Tumor of the Kidney.
  TFE3 -rearranged perivascular epithelioid cell tumors (PEComas) of the kidney are rare, with fewer than 50 examples reported in the literature. A 32-year-old man presented with an 8.2 cm right renal mass and bulky retroperitoneal lymphadenopathy, raising conce…
  pubmed Zhao T, Devins KM, Hung YP, Wu CL 2026 Feb 置信度 0.82
• Multimodal radiomics in glioma: predicting recurrence in the peritumoural brain zone using integrated MRI.
  Gliomas exhibit a high recurrence rate, particularly in the peritumoural brain zone after surgery. This study aims to develop and validate a radiomics-based model using preoperative fluid-attenuated inversion recovery (FLAIR) and T1-weighted contrast-enhanced …
  pubmed Li Q, Xiang C, Zeng X, Liao A 等 2025 Aug 11 置信度 0.82
• Long Used but Hardly Known: Synthesis and Crystal Structure of Tritium Breeding Li(2)Be(2)O(3).
  A main challenge for the operation of a nuclear fusion reactor is the consumption of tritium during the fusion process and the limited availability of tritium in natural resources or its production in nuclear power plants. The most promising approach is breedi…
  pubmed Krach G, Steinadler J, Calaminus R, Lotsch BV 等 2025 Aug 21 置信度 0.82
• Late-onset temporal lobe epilepsy: Enlarged amygdala-hippocampus indicates interictal epileptic activity at electroencephalography and memory impairment.
  Late-onset temporal lobe epilepsy (TLE) sometimes manifests with enlargement of the amygdala or hippocampus. This study aimed to clarify the yet unknown clinical significance of amygdala-hippocampal enlargement in late-onset TLE.
  pubmed Takeyama H, Matsumoto R, Usami K, Tojima M 等 2025 Oct 置信度 0.82
• The myeloid transcription factor Elf1 regulates genes with function in innate immunity.
  Transcription factor networks are critical hubs for organ development. Here, we investigated the hematopoietic function of the E-twenty six (Ets)-family transcription factor E74-like factor 1 (Elf1) that is normally predominantly expressed in monocytes. Striki…
  pubmed Varghese P, Garcia-Cuellar MP, Slany RK 2025 Nov 置信度 0.82
• A methodological study on measuring the activity of Ac-225 in targeted therapeutic radiopharmaceuticals using CdZnTe.
  Ac-225 is a promising radionuclide for clinical α-particle targeted cancer therapy. Accurate measurement of its activity is prerequisite for clinical applications. To explore viable methods for Ac-225 activity measurement in clinical settings, this study…
  pubmed Gu XB, Yu GB, Liu B, Xiang YX 等 2025 Nov 置信度 0.82
• Design and Construction Progress of a Cryogen-Free, Shielded 23.5-T REBCO Magnet for Benchtop 1-GHz NMR Spectroscopy.
  We present the detailed design and construction progress of a cryogen-free, shielded 23.5-T, 30-mm warm-bore REBCO magnet for use in benchtop 1-GHz microcoil nuclear magnetic resonance (NMR) spectroscopy. The magnet design, initially based on constant current …
  pubmed Park D, Dong F, Kim J, Bascuñán J 等 2025 Aug 置信度 0.82
• Photopharmacology reveals high-specificity linkage of Ca(2+) entry at TRPC6 nanodomains to NFAT activation in mast cells.
  Photopharmacology has recently emerged as a strategy for high-precision modulation of immune functions. Here we explored efficiency and specificity of interventions based on light-induced TRPC6 activation in the RBL-2H3 mast cell model.
  pubmed Krivić D, Panasiuk O, Pilic J, Malli R 等 2025 置信度 0.82
• Multi-module UNet++ for colon cancer histopathological image segmentation.
  In the pathological diagnosis of colorectal cancer, the precise segmentation of glandular and cellular contours serves as the fundamental basis for achieving accurate clinical diagnosis. However, this task presents significant challenges due to complex phenome…
  pubmed Liu Q, Zhao Z, Wu Y, Wu S 等 2025 Aug 7 置信度 0.82
• Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression.
  Mutations that initiate acute myeloid leukemia (AML) can cause clonal expansion without transformation (clonal hematopoiesis). Cooperating mutations, usually in signaling genes, are needed to cause overt disease, but these may require a specific fitness state …
  pubmed Kramer MH, Richardson SN, Li Y, Yin T 等 2025 Nov 3 置信度 0.82
• Depth Dose Profile and Exposure Time Calculation in an 60 Co Irradiation Processing Facility: MCNP and GEANT4 Calculation.
  The present research is proposing a mathematical method to calculate the dose absorbed by a moving object in a non-uniform radiation field. In such conditions, the dose is the function of time and position of the object relative to the radiation source. In thi…
  pubmed Tabbakh F, Chakoli AN, Tajudin SM, Tabbakh F 等 2026 May 1 置信度 0.82
• Ultrastructural insights into early myoblast differentiation induced by shockwave stimulation.
  Extracorporeal shockwave therapy (ESWT) is a non-invasive therapeutic modality that uses high-energy acoustic waves (shockwaves, SW) to restore local homeostasis and stimulate tissue healing and regeneration through mechanotransduction. ESWT has gained popular…
  pubmed Ryskalin L, Fulceri F, Soldani P, D'Agostino MC 等 2025 置信度 0.82
• Typical and atypical cell division versus potential meiosis and sex in euglenids.
  Euglenids typically reproduce asexually by closed intranuclear orthomitosis and longitudinal cell division. The nucleus divides without the dissolution of the nuclear envelope, and the spindle is radially symmetric. Typical longitudinal cell division begins in…
  pubmed Jedlička A, Barth O, Lihanová Bugajdová D, Beck T 等 2025 Aug 置信度 0.82
• TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
  Psoriasis (PS) is a chronic autoimmune skin disease that poses a serious threat to over 100 million patients worldwide. An increasing number of studies have indicated that keratinocytes (KCs) play an essential role in the inflammatory progression of PS. The pr…
  pubmed Long SJ, Zheng QY, Xu F, Li GQ 等 2025 Aug 置信度 0.82
• Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast.
  Genetic information is stored on multiple chromosomes in eukaryotic organisms and is passed on to offspring through cell division. How chromosome number influences cell division and chromosome segregation is not yet understood.
  pubmed Jiang Y, Jian Y, Nie L, Gu X 等 2025 Aug 4 置信度 0.82
• Segmentation of the Left Atrium in Cardiovascular Magnetic Resonance Images of Patients with Myocarditis.
  Cardiovascular magnetic resonance (CMR) cine sequences serve as the cornerstone imaging technique for evaluating dynamic left atrial (LA) function in myocarditis patients. By capturing three-dimensional motion characteristics throughout the cardiac cycle with …
  pubmed Wang W, Pan Z, Zhao Y, Wang S 等 2025 Jul 18 置信度 0.82
• Microfluidics for geosciences: metrological developments and future challenges.
  This review addresses the main metrological developments over the past decade for microfluidics applied to geosciences. Microfluidic experiments for geosciences seek to decipher the complex interplay between coupled, multiphase, and reactive processes in geolo…
  pubmed Roman S, Rembert F, Kovscek AR, Poonoosamy J 2025 Aug 19 置信度 0.82
• First Demonstration of Improved Fusion Yield with Increased Compression through Reduced Adiabat in Inertial Confinement Fusion Experiments at the National Ignition Facility.
  Recent advancements in indirect-drive inertial confinement fusion (ICF) experiments at the National Ignition Facility (NIF) have achieved a significant milestone by demonstrating target gains greater than one, yet future applications necessitate much higher ta…
  pubmed Hohenberger M, Clark DS, Humbird KD, Pak A 等 2025 Jul 18 置信度 0.82
• NUP98 Rearrangement Dynamics Predict Outcomes in Adult Patients With Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter Real-World Study.
  Acute myeloid leukemia with NUP98 rearrangements (NUP98r) is associated with poor prognosis, and while allo-HSCT remains the primary curative approach, its efficacy in NUP98r patients is still uncertain. The prognostic impact of NUP98 fusion partners, accompan…
  pubmed Yuan X, Ni L, Chen T, Wu Y 等 2025 Nov 置信度 0.82
• Extracellular metallothionein: An alarmin regulating lymphocyte gene expression, cell signaling, and immune function.
  Metallothionein (MT) is a highly conserved, low-molecular-weight (∼7 kDa), cysteine-thiol-rich, stress response protein essential to cellular homeostasis. Elevated MT levels can be induced in cells during response to oxidative stress, glucocorticoi…
  pubmed Maltz-Matyschsyk M, Melchiorre CK, Dostie-Laprise K, Lynes MA 2025 Sep 置信度 0.82
• Exploring the zinc-binding proteins in the mutational hotspots of human cancer.
  Mutations and zinc (Zn) ions are crucial in cancer biology. This study examines the tripartite relationship between mutations, zinc-binding proteins (ZBPs), and cancer. A total of 75 ZBPs were identified that may contribute to cancer after undergoing mutations…
  pubmed Chauhan S, Kulharia M, Verma SK 2025 Oct 置信度 0.82
• Enhanced Detection of Age-Related and Cognitive Declines Using Automated Hippocampal-To-Ventricle Ratio in Alzheimer's Patients.
  The hippocampal-to-ventricle ratio (HVR) is a biomarker of medial temporal atrophy, particularly useful in the assessment of neurodegeneration in diseases such as Alzheimer's disease (AD). To minimize subjectivity and inter-rater variability, an automated, acc…
  pubmed Fernandez-Lozano S, Fonov V, Schoemaker D, Pruessner J 等 2025 Aug 1 置信度 0.82
• Optimization of passive superconductors for shaping stellarator magnetic fields.
  We consider the problem of optimizing a set of passive superconducting coils (PSCs) with currents induced by a background magnetic field rather than power supplies. In the nuclear fusion literature, such coils have been proposed to partially produce the 3D mag…
  pubmed Kaptanoglu AA, Landreman M, Zarnstorff MC 2025 Jun 置信度 0.82
• Exploratory study of liquid-metal response to rapid variation of applied magnetic field.
  Transient plasma events, such as plasma disruptions, are anticipated in the future magnetic-confinement nuclear fusion reactors. The events are accompanied by a rapid change in the magnetic field generated by the plasma current and, accordingly, induction of s…
  pubmed Smolyanov I, Zikanov O 2025 Jun 置信度 0.82
• Nano polystyrene accelerated the reproductive toxicity induced by the Tris(1,3-dichloro-2-propyl) phosphate via Nhr-69-PISD-Drp-1-mediated mitochondrial fragmentation in Caenorhabditis elegans.
  Plastic products can degrade into micro/nano plastics (MNPs), which have the potential to adsorb Tris (1,3-dichloro-2-propyl) phosphate (TDCPP) from the environment, thereby creating biological co-exposure risks. Current researches indicate that TDCPP has endo…
  pubmed Wang J, Shi Y, Meng K, Sun M 等 2025 Nov 1 置信度 0.82
• Few-Electron Highly Charged Muonic Ar Atoms Verified by Electronic K X Rays.
  A highly charged muonic ion is a unique few-body atomic system where a negatively charged muon and a few electrons are simultaneously bound to a single nucleus. We report the first state-selective observation of highly charged muonic Ar (μAr) by electron…
  pubmed Okumura T, Azuma T, Bennett DA, Doriese WB 等 2025 Jun 20 置信度 0.82
• Timosaponin AIII inhibits gastric cancer by causing oxidative stress and blocking autophagic flux.
  Gastric cancer (GC) is a prevalent malignant tumor worldwide, with limited treatment targets. Timosaponin AIII (Tim AIII) is the naturally steroid saponin isolated from Anemarrhena, while this study initially confirms the anti-GC effect of Tim AIII.
  pubmed Zhu C, Chen S, Lu Y, Song J 等 2025 Oct 置信度 0.82
• Semantic consistency-guided patch-wise relation graph reasoning scheme for lung cancer organoid segmentation in brightfield microscopy.
  Patient-derived organoids (PDOs) have recently opened new possibilities for personalized precision medicine. Specifically, the segmentation of live PDOs in brightfield microscopy is essential for organoid morphological evaluation, cell viability assays, and dr…
  pubmed Lv T, Fan J, Chen Z, Liu Y 等 2025 Nov 置信度 0.82
• ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis.
  The acrosome is a crucial organelle essential for sperm function and male fertility. During acrosome biogenesis, numerous proacrosomal vesicles (PAVs) are transported to the concave region of the nuclear membrane and fuse to form the acrosome. However, the mec…
  pubmed Shao T, Ma J, Tan X, Shan H 等 2025 Aug 5 置信度 0.82
• ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections.
  Infections caused by nontuberculous mycobacteria, such as Mycobacterium avium and Mycobacteroides abscessus, are becoming increasingly prevalent, and rising antibiotic resistance poses a significant clinical challenge. However, the mechanisms by which the host…
  pubmed Jeon SM, Lee YJ, Lee SH, Kim SI 等 2025 Jul 29 置信度 0.82
• Metastatic Supratentorial Ependymoma: A Case Presentation and Systematic Review of the Literature.
  Ependymomas are categorized based on anatomical location and specific genetic alterations, with extra-axial metastasis being a rare event, occurring in less than 1% of cases and documented sparsely in the literature. This case study details a 27-year-old male …
  pubmed Tran KT, Virga J, Kurdi N, Chalupa KA 等 2025 Aug 置信度 0.82
• Characterization of Factors Associated with Tissue Immunity, Cellular Activity and Angiogenesis in Children with Unilateral Cleft Lip and Palate Before and During Primary Dentition: A Comparative Cross-Sectional Study.
  Introduction : Unilateral cleft lip and palate (CLP) is a severe orofacial birth defect characterized by improper fusion of facial parts and disturbed orofacial functions. The defect manifests as a gap in the orofacial tissues that is accompanied by defective …
  pubmed Ozola L, Pilmane M 2025 Jul 12 置信度 0.82
• The Coiled Coil and C2 Domains Modulate BCR Localization and BCR-ABL1 Compartmentalization, Transforming Activity and TKI Responsiveness.
  The BCR-ABL1 chimeric oncoprotein plays a pivotal role in the pathogenesis of Chronic Myeloid Leukemia (CML) as its constitutive kinase activity transforms the hematopoietic stem cell, promoting pro-survival signaling. We and others have previously shown that …
  pubmed Massimino M, Stella S, Romano C, Buffa P 等 2025 Jul 9 置信度 0.82
• The V5-Epitope Tag for Cell Engineering and Its Use in Immunohistochemistry and Quantitative Flow Cytometry.
  Synthetic biology has fundamentally advanced cell engineering and helped to develop effective therapeutics such as chimeric antigen receptor (CAR)-T cells. For these applications, the detection, localization, and quantification of heterologous fusion proteins …
  pubmed Fritschle K, Mielke M, Seelbach OJ, Mühlthaler U 等 2025 Jul 20 置信度 0.82
• Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
  Cisplatin (Cis) is a widely used chemotherapy drug, but its nephrotoxicity limits its clinical application. Acute kidney injury (AKI) is a common complication, restricting long-term use. This study investigates the mechanisms of cisplatin-induced AKI and explo…
  pubmed Liu J, Wang Y, Qiao P, Ying Y 等 2025 Jun 24 置信度 0.82
• NMR Insights Into the Structural Dynamics of p47, A Key Adaptor Protein of p97 in Golgi Reassembly.
  The Golgi apparatus undergoes systematic disassembly and reassembly during the cell cycle, a process requiring membrane fusion mediated by the AAA+ ATPase p97/VCP and its adaptor p47. While the p97-p47 complex plays a pivotal role in post-mitotic Golgi reassem…
  pubmed Black MK, Raseekan R, Kanters P, Kim P 等 2025 Dec 1 置信度 0.82
• A designer polyQ fusion protein modulates NF-κB signaling by sequestering P65/RelA into aggregates.
  The transcription factor P65 is a subunit of the NF-κB complex that regulates expression of pro-inflammatory cytokines, thereby controlling the innate immune response. Excessive activation of NF-κB is commonly associated with various chronic inflam…
  pubmed Zhang XL, Jiang LL, Duan HT, Hu HY 2025 Jul 27 置信度 0.82
• Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckle-paraspeckle crosstalk during cellular stress.
  Nuclear speckles (NS) and paraspeckles (PS) are adjacent yet distinct nuclear condensates that undergo stress-induced reorganization. Here, we identify a dual role for the splicing factor SRSF5 in coordinating the crosstalk between both condensates. Super-reso…
  pubmed Okuda EK, Kessler LF, Arnold B, Riegger RJ 等 2025 Jul 19 置信度 0.82
• Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients.
  The tumor ecosystem heterogeneity of papillary thyroid carcinoma (PTC) is poorly characterized in children and young adult patients (CAYA-PTC). In this study, single-cell RNA sequencing is used to profile transcriptomes from the paratumor and tumor tissues of …
  pubmed Guo K, Yang L, Huang Z, Qian K 等 2025 Oct 置信度 0.82
• Comprehensive Discrimination of Amomi Fructus From Different Origins Using UHPLC-Q-Orbitrap MS, HS-GC-MS/MS, NMR and MIR Technologies Based On Data Fusion Strategies.
  Amomi Fructus (SR) is an important edible herb widely used as a spice and traditional Chinese medicine. To comprehensively solve the serious practical problems of origins and species confusion in SR, the systematic characterization methods were established by …
  pubmed Zhang Y, Li Y, Li Z, Zhang Z 等 2025 Dec 置信度 0.82
• Unveiling microsecond diffusion bonding phenomena enabled by air plasma spraying zirconia thermal barrier ceramics onto rare earth environmental barrier silicates.
  While global propulsion and energy technology slowly progresses toward cleaner and renewable sources, gas turbine engines are still a workhorse infrastructure in these domains - for which achieving increased operating efficiency and reduced emissions is of sig…
  pubmed Gildersleeve V EJ, Bakan E, Rasinski M, Kindelmann M 等 2025 Jul 25 置信度 0.82
• Reduced dimensionality, elevated tolerance? A perspective on 2D materials for fusion diagnostics.
  Whether in the distant reaches of outer space or deep within magnetic confinement fusion reactors, our exploration of high-energy particle radiation environments continues to evolve-driving an urgent need for diagnostic technologies capable of withstanding ext…
  pubmed Szary MJ, El-Ahmar S, Prokopowicz R, Ciuk T 2025 Aug 6 置信度 0.82
• Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription.
  Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that controls tissue growth and human cancer. Despite these advances, our understanding of how Hippo signaling regulates transcription is …
  pubmed Kroeger B, Manning SA, Mohan V, Lou J 等 2025 Jul 25 置信度 0.82
• Dulaglutide markedly prevents peritoneal fibrosis in a rodent model of chronic kidney disease: Insights into the pathogenesis.
  Peritoneal fibrosis (PF) is a major complication of long-term peritoneal dialysis, leading to ultrafiltration failure and technique dropout, highlighting the urgent need for therapies that can preserve peritoneal membrane function and longevity. The present st…
  pubmed Yang CC, Yue Y, Wang YT, Chiang JY 等 2025 Oct 置信度 0.82
• Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study.
  Olfactory impairment is common in glioblastoma and has been associated with unfavorable overall survival. However, prior studies were limited by imbalances in key prognostic factors and the absence of longitudinal olfactory assessments to evaluate treatment-re…
  pubmed Oster C, Matyar A, Schmidt T, Hummel T 等 2025 Jul 24 置信度 0.82
• Loss of DAXX/ATRX Protein Expression Results in Ischemia Resistance and Radiation Sensitivity in Pancreatic Neuroendocrine Tumor Cells and Is Associated with Improved Response to Trans-Arterial Radioembolization.
  Metastatic liver pancreatic neuroendocrine tumors (PNETs) can be treated with ischemia-based trans-arterial embolization/trans-arterial chemo-embolization or radiation-based trans-arterial radioembolization (TARE). Guidelines for treatment selection are limite…
  pubmed Puzzuoli, Solivio C, Yuan G, Rizzo AJ 等 2025 置信度 0.82
• Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry.
  NUT carcinoma (NC) is an underdiagnosed, poorly differentiated squamous cell cancer with a median survival of 6.7 months. Defined by NUTM1 fusions, NC enhances oncogene transcription, including MYC. We investigated the ability of standard next-generation seque…
  pubmed Kim JJ, Walton SA, Mahadevan NR, Haradon J 等 2025 Sep 15 置信度 0.82
• APE1 Attenuates ALK Tyrosine Kinase Inhibitors Sensitivity in NPM1-ALK Positive Anaplastic Large Cell Lymphoma.
  Anaplastic lymphoma kinase (ALK), a tyrosine kinase receptor of the RTK insulin superfamily, was named after its initial identification in anaplastic large cell lymphoma (ALCL). Following a reciprocal chromosomal translocation with nucleophosmin 1 (NPM1), ALK …
  pubmed Liu Z, Jing X, Li D, Bao L 等 2025 Oct 置信度 0.82
• Integrative genomic and transcriptomic profiling reveals dysregulation of FOXA1-AGR2 axis in penoscrotal extramammary Paget's disease.
  Extramammary Paget's disease (EMPD) is a rare cutaneous mucinous adenocarcinoma primarily affect the penoscrotal skin, characterized by the presence of Paget cells scattered within the epidermis. The molecular features of Paget cells remain poorly understood.
  pubmed Zhang D, Gao S, Zhao C, Cai X 等 2025 Sep 置信度 0.82
• Detection of initial intra-cellular functional, structural and ultra-structural changes in virus-inoculated cells: A pilot study.
  Mammalian cells from embryonic mouse 3 T3 and bovine trachea (EBTr) lines were incubated in in vitro-conditions. A sub-population of from the EBTr cells was inoculated with low initial infectious titers of the vaccine avipoxviral strains FK (fowl), and an…
  pubmed Sainova I, Hadjiolova R, Petrov A, Dimitrova-Dikanarova D 等 2025 Oct 置信度 0.82
• Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model.
  Despite much-improved protocols that broadly suppress the adaptive immune cells, most allografts are still lost to chronic rejection, in which macrophages have been prominently featured in the graft. In both clinical and preclinical studies, the graft-infiltra…
  pubmed Su X, Deng G, Sun S, Wang G 等 2025 Oct 置信度 0.82