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• Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia.
  Leukemias with NUP98 rearrangements exhibit heterogeneous phenotypes such as acute myeloid leukemia, T-cell acute lymphoblastic leukemia (T-ALL), or myelodysplastic syndrome/neoplasms associated with fusion partners, whereas the mechanism responsible for this …
  pubmed Umeda M, Hiltenbrand R, Michmerhuizen NL, Barajas JM 等 2025 Oct 23 置信度 0.82
• C-terminal tagging impairs AGO2 function.
  MicroRNA-mediated gene silencing is a conserved mechanism of post-transcriptional gene regulation across metazoans. It depends on base pairing between small RNAs and mRNAs, and on protein complexes including the RNA-induced silencing complex (RISC), where Argo…
  pubmed Shah KM, Crozier AFF, Assaraf A, Arya M 等 2025 Dec 置信度 0.82
• Npl3 is required for efficient autophagosome-vacuole fusion.
  Macroautophagy/autophagy is a highly conserved catabolic membrane trafficking process through which various intracellular constituents, from proteins to organelles, are targeted for vacuolar/lysosomal degradation. Autophagy is tightly regulated both temporally…
  pubmed Yin Z, Zhang Z, Liu X, Klionsky DJ 2026 Jan 置信度 0.82
• Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies.
  Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 85% of tumor cells, telomerase formed by TERT and TE…
  pubmed Wang C, Chen W, Li R, Yang Y 等 2025 Jul 22 置信度 0.82
• ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.
  Ferroptosis, a type of programmed cell death dependent on iron, is characterized by lipid peroxidation of cellular membranes. However, the roles and underlying mechanisms of RNA-binding proteins (RBPs) in modulating ferroptosis in colorectal cancer (CRC) have …
  pubmed Wang S, Zhu L, Wang Y, Han Y 等 2025 Jul 23 置信度 0.82
• Enhanced Encoding Module of AisNet with Charge Features: An Application to the S(N)2 Data Set.
  This research introduces a charge-enhanced encoding module within the AisNet multifeature fusion framework, demonstrating superior force error accuracy and cross-model transferability, and achieving in state-of-the-art performance on the S N 2 dataset. Compare…
  pubmed Hu Z, Guo Y, Liu Z, Gu B 等 2025 Aug 11 置信度 0.82
• EWSR1::NFATC2 Rearranged Sarcoma : Distinct Clinicopathological Features From a Series of 5 Rare Cases.
  Ewing sarcoma (ES) is an undifferentiated round cell sarcoma affecting children and young adults. It is characterized by gene fusions involving one of the gene members of FET family ( EWSR1 ) and ETS transcription family members. Recent studies have observed c…
  pubmed Thirunavukkarasu B, Shukla P, Pushpam D, Meena R 等 2025 Sep 1 置信度 0.82
• YAP1::MAML2, YAP1::NUTM1, and RNF13::PAK2 rearrangements in trichoblastomas and adnexal tumors with panfollicular differentiation: expanding the spectrum of YAP1/PAK-fused skin adnexal tumors.
  In 2019, YAP1::MAML2 and YAP1::NUTM1 rearrangements were demonstrated in the majority of poromas and in porocarcinomas. Recently, our group demonstrated recurrent fusions of PAK (p21 (RAC1) activated kinase) 1/2/3 genes in a subset of poromas and porocarcinoma…
  pubmed Kervarrec T, Macagno N, Houlier A, Pissaloux D 等 2025 Oct 置信度 0.82
• Multimodal defect analysis and application of virtual machining for solid-state manufactured aluminium structure.
  Additive friction stir deposition (AFSD) is an emerging solid-state non-fusion additive manufacturing (AM) technology, which produces parts with wrought-like material properties, high deposition rates, and low residual stresses. However, impact of process inte…
  pubmed Yakubov V, Ostergaard H, Bhagavath S, Leung CLA 等 2025 置信度 0.82
• Case Report: "DEK::AFF2 fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies".
  DEK::AFF2 fusion-associated carcinomas of the sinonasal tract are exceedingly rare, with fewer than 100 cases reported worldwide, but probably underrecognized. Recently classified by the WHO as a distinct provisional subtype of non-keratinizing squamous cell c…
  pubmed Knebel M, Agaimy A, Kühn JP, Körner S 等 2025 置信度 0.82
• UM-CPP: A Universal Model for Efficient Classification of Protein Particles in cryo-EM Micrographs with Feature Engineering.
  Cryo-electron microscopy (cryo-EM) is a powerful tool for high-resolution structural analysis of proteins and viruses. However, a major challenge in cryo-EM data processing is the presence of heterogeneous samples, IC contamination, and extraneous impurities, …
  pubmed Yao Z, Wang H, Luo W, Zhan Y 等 2025 Jul 15 置信度 0.82
• Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model.
  Non-union remains a significant complication following ankle fusion procedures, underscoring the need for effective osteogenic adjuvants to improve boney healing and fusion outcomes. This study investigates the osteogenic potential of FK506 (Tacrolimus), both …
  pubmed Huffman N, Magesh A, Solomon H, Dingler C 等 2025 Oct 置信度 0.82
• BN-Fused Polycyclic Heteroarenes Containing Thiopyran Moieties: Synthesis, Aromaticity, and Dual-Chromic Behavior.
  BN-fused polycyclic heteroarenes have attracted extensive attention due to their distinctive structures and optoelectronic properties. However, the fusion of an azaborine ring on a six-membered thiopyran ring remains unexplored, limiting the chemical diversity…
  pubmed Guo H, Chen W, Zhou G 2025 Aug 18 置信度 0.82
• Mortalin and PINK1/Parkin-Mediated Mitophagy Represent Ovarian Cancer-Selective Targets for Drug Development.
  Mortalin is an essential chaperone for the import of nuclear-encoded proteins into mitochondria and is elevated in ovarian cancer in association with poor patient prognosis. The investigational new drug, SHetA2, interacts with mortalin releasing its client pro…
  pubmed Chandra V, Garland J, Rai R, Zhao D 等 2025 Oct 置信度 0.82
• Digital light processing 3D printing: Harnessing micro- and nanocellulose for advanced biocomposites.
  The integration of sustainable materials into additive manufacturing is critical for advancing environmentally responsible technologies. In this study, we demonstrate a novel approach to enhancing digital light processing (DLP) 3D printing resins by incorporat…
  pubmed Abidnejad R, Mousapour M, Meinander K, Baniasadi H 等 2025 Sep 置信度 0.82
• Engineered B7-H3-targeted VHH-Fc fusion antibody demonstrates rapid tumor accumulation for infrared imaging in pancreatic cancer xenograft model.
  B7 homolog 3 protein (B7-H3) represents a promising target for cancer diagnosis and therapy. Conventional B7-H3-targeting agents predominantly use IgG antibodies, which accumulate in tumors slowly due to their large molecular size (160-180 kDa, comprising…
  pubmed Mo X, Xu Y, Han F, Wang Y 等 2025 Nov 1 置信度 0.82
• The Clinical Impact of FAPI PET Imaging: HCC, CCC, CUP & Peritoneal Carcinoma.
  In recent years, FAP-targeted imaging has emerged as a highly-promising modality as a pan-cancer agent. Until now, several studies and review articles have focused on efficacy of FAPI imaging in epithelial malignancies with a high global incidence and prevalen…
  pubmed Novruzov E, Mamlins E, Mori Y, Cardinale J 等 2025 Sep 置信度 0.82
• Cross-modality image-to-image translation from MR to synthetic (18)F-FDOPA PET/MR fusion images using conditional GAN in brain cancer.
  This study aims to identify the possibility of cross-modality image-to-image translation from magnetic resonance (MR) to synthetic positron emission tomography (PET)/MR fusion images using conditional generative adversarial networks (CGAN).
  pubmed Seo Y, Yang H, Kong E, Sanker V 等 2025 Oct 置信度 0.82
• Impact of x rays on the sensitivity of CR-39 detectors to 2.4-MeV protons.
  Solid-state nuclear track detectors, such as CR-39, lose sensitivity when subjected to doses of x rays on the order of 1 Gy in nuclear-fusion relevant experiments. As a result, the formed tracks have, in general, smaller maximum radii and shallower maximum dep…
  pubmed Kishimori R, Cufari M, Zhong-Johnson EZL, Buschmann BI 等 2025 Jul 1 置信度 0.82
• PTCH1::GLI1 Fusion Tumors of the Ovary: A Clinicopathologic Study of 3 Cases.
  GLI1 -altered tumors of the gynecologic tract are extremely rare. We report 3 cases of ovarian PTCH1::GLI1 fusion tumor in patients ranging from 54 to 58 yrs of age, who presented with unilateral FIGO stage I tumors. The tumors ranged from 12 to 20 c…
  pubmed Bakkar R, Afkhami M, Balzer B, Maluf H 等 2025 Nov 1 置信度 0.82
• Significantly Large Negative Ion Formation in Grazing Scattering of Neutral Deuterium and Tritium Atoms from a CsI(100) Surface.
  We present the theoretical evidence of the formation of significantly large fractions of negative ions during grazing scattering of deuterium (D) and tritium (T) atoms from a CsI(100) surface. The negative ion conversion efficiency increases to an impressive &…
  pubmed Wang Y, Zhou H, Wang H, Li Y 等 2025 Jul 31 置信度 0.82
• The Significance of Cytoplasmic STAT6 Positivity and High p53/p16 Expression as a Novel Predictor of Histological/Clinical Malignancy in NAB2::STAT6 Fusion-Positive Orbital Solitary Fibrous Tumors.
  Orbital solitary fibrous tumor (SFT) is an extremely rare variant of systemic SFTs. However, the relationship between the biological/clinical characteristics, histological malignancies, and known oncogenes of systemic SFTs has not yet been elucidated. Therefor…
  pubmed Adachi S, Kondo A, Ogino I, Suzuki M 等 2025 Oct 置信度 0.82
• Illuminating radiogenomic signatures in pediatric-type diffuse gliomas: insights into molecular, clinical, and imaging correlations. Part II: low-grade group.
  The fifth edition of the World Health Organization classification of central nervous system tumors represents a significant advancement in the molecular-genetic classification of pediatric-type diffuse gliomas. This article comprehensively summarizes the clini…
  pubmed Kurokawa R, Hagiwara A, Ito R, Ueda D 等 2025 Sep 置信度 0.82
• daf-16/FOXO promotes the activity of ligand-bound DAF-12/NHR to coordinate dauer exit and post-dauer seam cell fate.
  The mechanisms by which developmental pathways are modulated to accommodate periods of arrest are poorly understood. In Caenorhabditis elegans larvae that encounter adverse environments, dauer diapause can interrupt developmental progression after the second l…
  pubmed Wirick MJ, Smith IT, Olson BS, Alessi AF 等 2025 Aug 12 置信度 0.82
• Prospects and Challenges of Proton Conducting Cerates in Electrochemical Hydrogen Devices for Clean Energy Systems: A Review.
  The growing demand for green energy and global concern about environmental issues raise the demand for alternative, environmentally friendly energy sources. Electrochemical hydrogen devices are widely investigated as a potential solution for clean and renewabl…
  pubmed Hossain MK, Das RC, Hossain MI, Rahman MA 等 2025 Jul 置信度 0.82
• Predicting radionuclide behavior in deep geological repositories using graph convolutional long short-term memory.
  Deep geological repositories (DGRs) are designed for the permanent disposal of spent nuclear fuel, necessitating precise radionuclide transport predictions. Owing to the impracticality of large-scale physical experiments, computational simulations are a key al…
  pubmed Jeong DS, Lee J, Pyo J, Baek SS 等 2025 Sep 15 置信度 0.82
• CO(2) and UV Laser-Induced Graphene Based on Polymer Transformation: Advanced Characterizations by 2D Raman Mapping Combined with Microscopy Techniques.
  Since its discovery, laser-induced graphene (LIG) has attracted much interest because this technique, having all the advantages of a laser processing technology, is more convenient and cost-effective than other graphene production methods. This work offers a d…
  pubmed Botti S, Bonfigli F, Bruttomesso A, Micciulla F 等 2025 Jul 1 置信度 0.82
• Deep Learning-Enhanced Spectroscopic Technologies for Food Quality Assessment: Convergence and Emerging Frontiers.
  Nowadays, the development of the food industry and economic recovery have driven escalating consumer demands for high-quality, nutritious, and safe food products, and spectroscopic technologies are increasingly prominent as essential tools for food quality ins…
  pubmed Lun Z, Wu X, Dong J, Wu B 2025 Jul 2 置信度 0.82
• Mitochondrial Quality Control in Bovine Oocyte Maturation: Mechanisms, Challenges, and Prospects for Enhancing Reproductive Efficiency.
  Oocyte maturation represents a fundamental biological process in bovine reproduction, establishing the physiological basis for fertilization and early embryonic development while critically determining the propagation of improved varieties and breeding efficie…
  pubmed Zhang YR, Xu DJ 2025 Jul 7 置信度 0.82
• Regulation of Mitochondrial Metabolism by Mfn1 Gene Encoding Mitofusin Affects Cellular Proliferation and Histone Modification.
  Mitochondria maintain cellular homeostasis through the dynamic balance of fusion and fission, which relies on nuclear-encoded mitochondrial fusion proteins, mitofusins 1 and 2 (Mfn1, Mfn2). Changes in Mfn1 and Mfn2 expression significantly affect mitochondrial…
  pubmed Xu H, Zhao X, Yun Y, Gao Y 等 2025 Jul 2 置信度 0.82
• Roles of human SPATA3 in cell proliferation and expression pattern of Spata3 in mouse testis.
  Male infertility predominantly manifests as abnormal spermatogenesis and maturation, abnormal semen quality, chromosomal abnormalities, and endocrine dysfunction. The present study aimed to explore the role, expression pattern and localization of spermatogenes…
  pubmed Fu L, Zhou B, Jiang X, Cheng J 等 2025 Sep 置信度 0.82
• Efficient gene editing of BMP15, GDF9, and MSTN-but not the imprinted CLPG gene-in goat embryos via electrotransfection and handmade cloning.
  CRISPR/Cas9 technology represents a powerful tool for advancing livestock breeding by enabling precise, on-target gene edits without the genomic mixing associated with traditional introgression methods. In this study, we employed a dual gRNA-based CRISPR/Cas9 …
  pubmed Hajian M, Pirali A, Moghaddam SHH, Moradi-Hajidavaloo R 等 2025 Jul 10 置信度 0.82
• Papillary Thyroid Carcinoma With a Rare TFG-MET Fusion in a Chernobyl Survivor: A Case Report.
  Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, with several histologic subtypes, including the follicular subtype (follicular variant of papillary thyroid carcinoma (FVPTC)). While BRAF V600E mutations are frequently associated w…
  pubmed Jacob A, Patel HJ, Andani S, Jiang XS 2025 Jun 置信度 0.82
• Speciation of cesium in a radiocesium-bearing microparticle emitted from Unit 1 during the Fukushima nuclear accident by XANES spectroscopy using transition edge sensor.
  The chemical state of radiocesium (RCs) was determined using X-ray absorption near-edge structure (XANES) in fluorescence mode and microbeam X-ray fluorescence (μ-XRF) mapping for the cesium (Cs) incorporated in a radiocesium-bearing silica microparticle…
  pubmed Takahashi Y, Miura H, Yamada S, Sekizawa O 等 2025 Sep 5 置信度 0.82
• Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans.
  The UFD-1 (ubiquitin fusion degradation 1)-NPL-4 (nuclear protein localization homolog 4) heterodimer is involved in extracting ubiquitinated proteins from several plasma membrane locations, including the endoplasmic reticulum. This heterodimer complex helps i…
  pubmed Rao R, Aballay A, Singh J 2025 Jul 6 置信度 0.82
• Cellular Identification of Single-Base Mutations in KRAS Gene Fragments Based on Nonhomologous Spectroscopic Data Fusion Modeling.
  The sensitivity of KRAS gene mutation detection in colorectal cancer (CRC) can affect prognosis. This study established a nonhomologous spectroscopic data fusion method based on nuclear magnetic resonance (NMR) and laser tweezers Raman spectroscopy (LTRS), in …
  pubmed Wang C, Abudureyimu A, Zhang Q, You W 等 2025 Oct 置信度 0.82
• Deep fusion model integrating whole slide images and preoperative MRIs for survival prediction in IDH wild-type glioblastoma.
  Glioblastoma (GBM) is an aggressive and highly malignant brain tumor, with isocitrate dehydrogenase (IDH) wild-type GBM being particularly notable for its poor prognosis. We developed the IDH wild-type Glioblastoma Integrated Survival Model (iGISM), a multimod…
  pubmed Guo X, Lai M, Zhang J, Wang L 等 2025 Oct 置信度 0.82
• Transcriptional gene fusions via targeted integration at safe harbors for high transgene expression in Chlamydomonas reinhardtii.
  Conventional genetic engineering in green microalgae employs error-prone nonhomologous end joining to integrate recombinant DNA at double-strand breaks generated at random positions across the nuclear genome. This typically results in variable transcription st…
  pubmed Jacobebbinghaus N, Bigge F, Saudhof M, Hübner W 等 2025 Sep 置信度 0.82
• [A case of acute promyelocytic leukemia with NUP98::RARG::LINE-L2a tripartite fusion and the mechanism of resistance to all-trans retinoic acid].
  This study reports a novel case of acute promyelocytic leukemia (APL) characterized by a tripartite fusion gene, NUP98::RARG::LINE-L2a, formed by the rearrangement of nucleoporin 98 (NUP98), retinoic acid receptor gamma (RARG), and long interspersed nuclear el…
  pubmed Che YN, Zhou XS, Chen JQ, Wang ZE 等 2025 Jul 8 置信度 0.82
• Modulation of mitochondrial dysfunction: Mechanisms and strategies for the use of natural products to treat stroke.
  Modulations of mitochondrial dysfunction, which involve a series of dynamic processes such as mitochondrial biogenesis, mitochondrial fusion and fission, mitochondrial transport, mitochondrial autophagy, mitochondrial apoptosis, and oxidative stress, play an i…
  pubmed Qin N, Liu R, Deng R, Shi L 等 2026 Jun 1 置信度 0.82
• Lutetium-177 Theranostics and Dosimetry for Neuroendocrine Neoplasms and Prostate Cancer.
  pubmed Wong KK, Hu E, Akhavanallaf A, Dewaraja YK 等 2025 Jul 置信度 0.82
• First-in-human results of terbium-161 [(161)Tb]Tb-PSMA-I&T dual beta-Auger radioligand therapy in patients with metastatic castration-resistant prostate cancer (VIOLET): a single-centre, single-arm, phase 1/2 study.
  Terbium-161 ( 161 Tb) emits beta-radiation similar to lutetium-177 ( 177 Lu), with additional radiation over ultra-short path lengths from Auger electrons. 161 Tb has shown superior in-vitro and in-vivo efficacy compared with 177 Lu. We aimed to evaluate the s…
  pubmed Buteau JP, Kostos L, Jackson PA, Xie J 等 2025 Aug 置信度 0.82
• Pulmonary mesenchymal cystic hamartoma with EWSR1::CREM fusion: molecular redefinition and diagnostic implications.
  Pulmonary mesenchymal cystic hamartoma (MCH) is an exceptionally rare benign tumor characterized by cystic-solid architecture and biphasic epithelial-mesenchymal components. We report a 56-year-old woman with a 2.6-cm right lower lobe mass, histologically comp…
  pubmed Lei H, Li X, Zhang H, Hu J 等 2026 Jul 置信度 0.82
• Pediatric mesenchymal chondrosarcoma with archetypal histology in the absence of HEY1::NCOA2 gene fusion: a molecular-morphological paradox.
  Mesenchymal chondrosarcoma (MC) is a rare, aggressive malignancy characterized by a distinctive biphasic histological pattern and frequently associated with the HEY1::NCOA2 fusion gene. We report a case of a 17-year-old male presenting with a mandibular mass i…
  pubmed Trimukhe A, Mridha AR, Rastogi S, Surya V 等 2025 Aug 置信度 0.82
• SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
  During diabetic kidney disease (DKD), tubulointerstitial fibrosis persists, although several methods have been applied to reduce albuminuria levels. In this research, we found that bovine serum albumin (BSA)-induced renal tubular cell injury could also spread …
  pubmed Zheng Z, Chen J, Xue X, Ma X 等 2025 置信度 0.82
• A Novel Two-step Classification Approach for Differentiating Bone Metastases From Benign Bone Lesions in SPECT/CT Imaging.
  This study aims to develop and validate a novel two-step deep learning framework for the automated detection, segmentation, and classification of bone metastases in SPECT/CT imaging, accurately distinguishing malignant from benign lesions to improve early diag…
  pubmed Xie W, Wang X, Liu M, Mai L 等 2025 Sep 置信度 0.82
• Stepwise identification of an SQSTM1::NTRK3 fusion in papillary thyroid carcinoma: Diagnostic pitfalls and the value of integrative genomic profiling.
  A 70-year-old woman presented with bilateral cervical lymphadenopathy and multiple pulmonary nodules. She had undergone right thyroid lobectomy in childhood. Ultrasonography revealed a newly identified mass in the remnant left thyroid lobe and enlarged cervica…
  pubmed Okubo Y, Kadoya M, Toda S, Nasu R 等 2025 Aug 置信度 0.82
• Detection of a new heterozygous pathogenic NFIA variant in metopic craniosynostosis with preaxial polysyndactyly: A case report.
  Craniosynostosis is a congenital condition caused by the early fusion of one or more skull vault sutures during embryological development, resulting in an abnormal head shape. This condition has been linked to many gene variants. The authors report a case of a…
  pubmed Nhongo SS, Simpson E, Halsnad M, Sangra M 等 2025 Sep 置信度 0.82
• Non-contrast computed tomography radiomics model to predict benign and malignant thyroid nodules with lobe segmentation: A dual-center study.
  Accurate preoperative differentiation of benign and malignant thyroid nodules is critical for optimal patient management. However, conventional imaging modalities present inherent diagnostic limitations.
  pubmed Wang H, Wang X, Du YS, Wang Y 等 2025 Jun 28 置信度 0.82
• Pretargeted Anti-CD20 Radioimmunotherapy with scFv Fusion Protein Safely Combines with BEAM and ASCT in Patients with High-risk B-cell Lymphomas.
  Despite new therapies, many patients with non-Hodgkin lymphoma (NHL) relapse and need more effective salvage therapies. This study (NCT02483000) evaluated the safety of B9E9-FP, a tetrameric single-chain anti-CD20-streptavidin fusion protein used in pretargete…
  pubmed Orozco JJ, Matesan MC, Lundberg SJ, Haaf RL 等 2025 Dec 2 置信度 0.82
• Hydrogen Isotope ((1)H/(2)H/(3)H) Separation in Solution Using Graphene Transferred on PTFE-Reinforced Nafion.
  The separation and enrichment of tritium from radioactive wastewater remain critical challenges in the nuclear power and fusion industries. While hydrogen isotope separation from H 2 /D 2 gas mixtures has been demonstrated using electrochemical pumping systems…
  pubmed Kim H, Kim H, Singh BK, Park J 等 2025 Jul 16 置信度 0.82
• Dissection of the MeCP2 repressor protein enables CRISPR platform optimization via localization engineering.
  Clustered regularly interspaced short palindromic repeat interference (CRISPRi), the fusion of nuclease-inactive Cas9 with transcriptional repressor domains, is a powerful platform enabling site-specific gene knockdown across diverse biological contexts. Previ…
  pubmed Kristof A, Karunakaran K, Ferry Y, Briggs S 等 2025 Jan 10 置信度 0.82
• A methodological design and an empirical study for assessing the maturity of an UASR based on the AHP-EWM and the FSEM fusion model.
  A multi-model fusion evaluation method based on indexes construction is discussed in this paper for evaluating the maturity level of an Uncertainty Analysis System for Radiotherapy (UASR). First, a system for evaluating the capability maturity of the UASR is e…
  pubmed Guo C, Tang B 2025 Jul 1 置信度 0.82
• A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments.
  Homologous recombination (HR) is essential for the repair of DNA double-strand breaks and the restart of stalled replication forks. A critical step in HR is the formation of Rad51 nucleofilaments, which perform homology search and strand invasion of a homologo…
  pubmed Ma E, Lakhal F, Litsardaki E, Ruault M 等 2025 Jul 1 置信度 0.82
• Deficits in mitochondrial dynamics and iron balance result in templated insertions.
  Mitochondrial membrane dynamics control the shape, number, and distribution of mitochondria and regulate energy production and cell health. In a screen for yeast mutants with increased levels of templated insertions (~10-1000 bp) in the nuclear genome, …
  pubmed Fox J, Yu Y, Yu Y, Thakre P 等 2025 Jul 1 置信度 0.82
• Quantum phase transition in the Casten pyramid using entanglement entropy in the semi-classical approximation of IBM-2.
  In this research, the quantum phase transition (QPT) in the Casten pyramid has been investigated using entanglement entropy. Energy surfaces and the entanglement entropy have been obtained within the framework of semi-classical approximation interacting boson …
  pubmed Ghapanvari M, Sayedi M, Jafarizadeh MA, Amiri N 2025 Jul 1 置信度 0.82
• Radioactive geophysical processing and spatial anomalies analysis based on adaptive weighting fusion and multifractal SVM.
  To improve the limitation associated with a single data set and obtain more comprehensive anomaly information, this paper adopts the adaptive weighting fusion and multifractal SVM method for radioactive exploration data processing. Firstly, the adaptive weight…
  pubmed Lv W, Huang P, Yang Y, Ning J 等 2025 Jul 2 置信度 0.82
• Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer.
  Deciphering the structural variation across tumour genomes is crucial to determine the events driving tumour progression and better understand tumour adaptation and evolution. High grade serous ovarian cancer (HGSOC) is an exemplar tumour type showing extreme,…
  pubmed Ewing A, Meynert A, Silk R, Aitken S 等 2025 Jul 1 置信度 0.82
• A prior knowledge-supervised fusion network predicts survival after radiotherapy in patients with advanced gastric cancer.
  Predicting overall survival (OS) for advanced gastric cancer patients after radiotherapy is critical for developing an individualized treatment plan. However, existing studies have focused on gastric cancer CT images with a large amount of redundant informatio…
  pubmed Sun L, Lan Y, Sun J, Ji P 等 2025 Sep 置信度 0.82
• STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans.
  STRIPAK is an evolutionarily conserved signaling complex that coordinates diverse cellular processes across fungi and animals. In the human fungal pathogen Cryptococcus neoformans, STRIPAK was recently shown to play critical roles in maintaining genome stabili…
  pubmed Peterson PP, Croog S, Choi Y, Sun S 等 2025 Jun 置信度 0.82
• Substantial decrease in tumor dose over subsequent cyles of [(177)Lu]Lu-PSMA-radioligand treatment.
  pubmed Bogsrud TV, Durski JM, Engelsen O, Zhang J 等 2025 Dec 置信度 0.82
• Temperature-Dependent Modulation of ECS-Mediated Haploid Induction in Arabidopsis thaliana.
  pubmed Zhao Z, Ma H, Zhang X, Shi C 等 2025 Oct 置信度 0.82
• Research on Bearing Fault Diagnosis Method for Varying Operating Conditions Based on Spatiotemporal Feature Fusion.
  In real-world scenarios, the rotational speed of bearings is variable. Due to changes in operating conditions, the feature distribution of bearing vibration data becomes inconsistent, which leads to the inability to directly apply the training model built unde…
  pubmed Wang J, Wang Y, Yu J, Li Q 等 2025 Jun 17 置信度 0.82
• Phase Evolution and Synthesis of Be(12) Nb Intermetallic Compound in the 800-1300 °C Temperature Range.
  Beryllium-based intermetallic compounds, such as Be 12 Nb, are attracting growing interest for their high thermal stability and potential to replace pure beryllium as neutron reflectors and multipliers in both fission and future fusion reactors, with additiona…
  pubmed Udartsev S, Kenzhina IE, Kulsartov T, Samarkhanov K 等 2025 Jun 19 置信度 0.82
• Integrating NMR and MS for Improved Metabolomic Analysis: From Methodologies to Applications.
  Metabolomics, the comprehensive analysis of low-molecular-weight metabolites (typically below 1500 DA) in biological systems, relies heavily on mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Each technique has inherent strengths and …
  pubmed Homobono Brito de Moura P, Leleu G, Da Costa G, Marti G 等 2025 Jun 17 置信度 0.82
• Pioneering but overlooked 1938 fusion experiment is recreated at last.
  pubmed 2025 Jul 置信度 0.82
• (18)F-fluorodeoxyglucose PET/CT scans for thoracic tuberculosis: current evidence and future perspectives.
  The advent of positron emission tomography (PET) combined with computed tomography (CT) in the field of inflammatory/infectious diseases heralds an era of personalised disease management using these noninvasive technologies. This nuclear medicine technique can…
  pubmed Santos AP, Souza Rodrigues R, Aarntzen EHJG, Rosado de Castro PH 等 2025 May 置信度 0.82
• Biomimetic, Peptide-guided Silica Formation by Real-time NMR of Elastin-like and R5 Fusion Peptides - Bimodal Peptide Aggregation Drives Dual-pathway Silicification Mechanisms.
  Biomimetic silica particles are promising materials for applications in drug delivery, enzyme encapsulation, and environmental technologies due to their intrinsic biocompatibility and eco-friendly nature. Often, these composites are formed via peptide self-ass…
  pubmed Brandis D, Obrist D, Haßler MFT, Kurzbach D 2025 Dec 1 置信度 0.82
• Intratracheal Administration of Polystyrene Micro(nano)plastics with a Mixed Particle Size Promote Pulmonary Fibrosis in Rats by Activating TGF-β1 Signaling and Destabilizing Mitochondrial Dynamics and Mitophagy in a Dose- and Time-Dependent Manner.
  Microplastics (MPs) can be inhaled by people. However, the relationships between long-term exposure to inhaled MPs, pulmonary fibrosis, and mitochondrial dysfunction are not completely clear.
  pubmed Xia S, Yuan C, Long W, Wu Z 等 2025 Jun 9 置信度 0.82
• Experimental and evolutionary evidence for horizontal transfer of an envelope fusion protein gene between thogotoviruses and baculoviruses.
  Baculoviruses are insect-specific viruses with large, double-stranded DNA genomes classified into four genera. Alphabaculoviruses, which infect lepidoptera, are further divided into group I (G1-α) and group II (G2-α). The GP64 protein, essential fo…
  pubmed Milhomem Pilati Rodrigues B, Janssen L, da Silva LA, Acacio SSVG 等 2025 Jul 22 置信度 0.82
• Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition.
  Monoclonal antibodies (mAbs) are multidomain glycosylated proteins that mediate antigen binding, among other protein-protein interactions, which makes them successful therapeutics. However, in many cases, adverse physicochemical properties can affect their ant…
  pubmed Bhattacharya A, Sinha S, Dash R, Rathore A 等 2025 Jul 15 置信度 0.82
• Excellent response to trametinib and low dose chemotherapy in a patient with rare RAF1 mutated sarcoma in a tertiary care center in India.
  With the advent of next-generation sequencing, increasingly we can sub classify the soft tissue sarcomas into various subtypes with distinct prognostic and therapeutic implications. Sarcomas with RAF1 mutations are extremely rare and so far, the treatment stra…
  pubmed Govind A, Rastogi S, Pasricha S, Ahmed S 等 2025 置信度 0.82
• The effect of weberite arrangement on the mechanical, thermophysical, and electronic properties of actinide-doped Gd(2)Zr(2)O(7).
  This study employs density functional theory with Hubbard U correction (DFT+ U ) to investigate the influence of the weberite motif on the elastic moduli, Debye temperature, thermal conductivity, and electronic structures of actinides (Th, U, Np, Pu, and Am) i…
  pubmed Zhao F, Tian Y, Wang H, Teng Z 等 2025 Jul 10 置信度 0.82
• Antiosteoclastogenic Indole Alkaloids from the Mangrove Endophytic Fungus Penicillium brefeldianum GXIMD 02511.
  Eight new prenylated indole alkaloids, brefeldindoles A-F ( 1 - 6 ), G ( 8 ), and H ( 11 ), together with 17 known analogues, were obtained from the Beibu Gulf mangrove-derived fungal strain Penicillium brefeldianum GXIMD 02511. Their structures, including abs…
  pubmed Wang J, Li R, Lin M, Chen C 等 2025 Jul 25 置信度 0.82
• Space- and Time-Defined Monte Carlo Dosimetry Explains Ovarian Cancer Cell Viability in Targeted α-Particle Therapy With Astatine 211-ParaThanatrace.
  Radiopharmaceutical therapy (RPT) aims to irradiate tumors using antibodies or small molecules chelated with radioisotopes that target tumor cells. The biological response resulting from the complex interplay between radioisotope decay and cell binding process…
  pubmed Onecha VV, Suarez-García D, Bosque JJ, Lee H 等 2025 Nov 1 置信度 0.82
• The combination of FLI, ITS, pFF, and citrate improves the developmental potential of gilt oocytes during in vitro maturation.
  The intrinsic quality of porcine oocytes is a critical determinant of early embryonic development during in vitro production (IVP). This study investigated the effects of chemically defined in vitro maturation (IVM) systems supplemented with glutamine, GlutaMA…
  pubmed Chen Z, Zhang C, Yan C, Peng C 等 2025 Aug 置信度 0.82
• Investigating the metastability of amorphous calcium carbonate by droplet microfluidics experiments using machine learning.
  Amorphous calcium carbonate (ACC) plays an important role in the crystallization pathways of calcite and its polymorphs influencing many natural and anthropogenic processes, such as carbon sequestration. Characterizing the dissolution rate of ACC in presence o…
  pubmed Santoso R, Guignon L, Deissmann G, Poonoosamy J 2025 Jun 20 置信度 0.82
• T-cell dysregulation informs radiotherapy-immunotherapy response in B-cell lymphoma: results from a phase 1 trial.
  Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are highly radiosensitive with immune-driven abscopal responses reported. Programmed cell death 1/programmed cell death ligand 1 (PD-L1) inhibitors are relatively ineffective in DLBCL/FL; howev…
  pubmed Hawkes EA, Palmer JB, Khor R, Lee ST 等 2025 Oct 28 置信度 0.82
• Adrenal causes of endocrine hypertension in childhood or adolescence.
  Arterial hypertension is characterised by elevated blood pressure (BP) leading to cardiovascular morbidity and mortality, and organ damage. Its prevalence in childhood is around 5% and children should be screened from 3 years of age. Hypertension in childhood …
  pubmed Pellegrini B, Bonaventura I, Hasenmajer V, Simeoli C 等 2025 Nov 置信度 0.82
• TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division.
  TRAPPC2L is a core subunit of the Transport Protein Particle (TRAPP) complex, which is involved in vesicle transport and autophagy. Mutations in Trappc2l gene are associated with neurodevelopmental disorders, characterised by severe neurodevelopmental delays a…
  pubmed Wang M, Li J, Liu B, Shen Z 等 2025 Jun 置信度 0.82
• Combination of ultrasound-based radiomics and deep learning with clinical data to predict response in breast cancer patients treated with neoadjuvant chemotherapy.
  Accurate assessment of NAC efficacy is crucial for determining appropriate surgical strategies and guiding the extent of surgical resection in breast cancer. Therefore, this study aimed to design an integrated predictive model combining ultrasound imaging, dee…
  pubmed Tenghui W, Xinyi L, Ziyi S, Yanting Z 等 2025 置信度 0.82
• KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
  NUP98 fusion oncoproteins (FO) are a hallmark of childhood acute myeloid leukemia. NUP98 FOs drive leukemogenesis through phase-separated condensate formation and maintenance of an active chromatin landscape at stem cell-associated genes in cooperation with ep…
  pubmed Michmerhuizen NL, Heikamp EB, Iacobucci I, Umeda M 等 2025 Oct 6 置信度 0.82
• Circular saw blade wear status prediction based on generative adversarial network and CNN-LSTM model.
  Monitoring the status of circular saw blades is an effective measure to ensure the production efficiency and safety of spent fuel assembly cutting. However, the prediction of wear during the cutting of stainless steel shells of spent fuel assemblies by circula…
  pubmed Zeng C, Wang C, Xiong X, Wang X 等 2025 置信度 0.82
• [Solitary fibrous tumor of common bile duct: case report and literature review].
  Solitary fibrous tumor (SFT) is a rare mesenchymal tumor. SFT was first described by Klemperer and Rabin in 1931. They described a fibrous tumor of the pleura. Currently, isolated cases of SFT of the gallbladder and common bile duct have been described in the …
  pubmed Suraev DE, Moskalets MV, Sokolov SA, Chankina AA 等 2025 置信度 0.82
• Identification of intracranial solitary fibrous tumor and atypical meningioma by multi-parameter MRI-based radiomics model.
  The preoperative distinction between atypical meningioma (AM) and intracranial solitary fibrous tumor (SFT) holds significant importance in guiding surgical approach decisions and prognostic assessments.
  pubmed Fan Y, Liu P, Zhang J, Wang L 等 2025 Jun 17 置信度 0.82
• A large-dynamic-range high-time-resolved transmission grating spectrometer for the measurement of broadband x-ray spectrum.
  The temporal measurement of broadband x-ray spectrum is important for the study of x-ray sources and their applications in high-energy-density plasmas. A spectrometer with a large dynamic range is required for these measurements. In this paper, a large-dynamic…
  pubmed Zhu T, Song T, Huang C, He X 等 2025 Jun 1 置信度 0.82
• Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.
  Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenesis, detect…
  pubmed Shi B, Yang P, Qiao H, Yu D 等 2025 置信度 0.82
• Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells.
  Rationale: Radiopharmaceutical therapy (RPT) has become an effective treatment option for neuroendocrine tumors (NETs) and castration-resistant prostate cancer and is in clinical development for many indications. One of the major advantages of theranostic RPT …
  pubmed Nguyen N, Min Y, Rivière J, van der Garde M 等 2025 置信度 0.82
• Instrumented micro/macroindentation of porosity defects in laser powder bed fusion 316L stainless steel.
  Porosity defects and their effect on mechanical properties remain a concern in metals-based laser powder bed fusion, even for optimized process parameters. Instrumented micro/macroindentation with Berkovich and spherical tips to forces of 50 N and 150&#xa…
  pubmed Weaver JS, Yin H, Redford J, Lou X 2025 置信度 0.82
• Radiopharmaceuticals in Prostate Cancer: General Considerations and Utility in Combination With EBRT.
  The management of prostate cancer has posed challenges for clinicians in determining optimal treatment strategies. Over the years, various radiopharmaceuticals have been utilized for both the diagnosis and treatment of the prostate cancer. Recent advancements …
  pubmed Civan C, Guberina N, Krafft U, Fendler WP 等 2025 Jul 置信度 0.82
• Identification of Small Open Reading Frame-Encoded Peptides in Glioma by an Optimized Proteomics Strategy.
  Small open reading frame-encoded peptides (SEPs), translated from previously unannotated genomic regions, have emerged as important regulators in diverse physiological and pathological processes. While ribosome profiling and bioinformatics analysis can predict…
  pubmed Zhang T, Cheng J, Li J, Ye Z 等 2025 Jul 置信度 0.82
• Case Report: Extrarenal TFE3 fusion-related renal cell carcinoma.
  Transcription factor binding to IGHM enhancer 3 ( TFE3 ) fusion-related renal cell carcinoma ( TFE3 -RCC) is a rare subtype of RCC. Its pathogenesis is primarily associated with chromosomal translocations resulting in TFE3 fusions. TFE3 -RCC is most commonly o…
  pubmed Yang Z, Li T, Lv K, Zhang X 2025 置信度 0.82
• Enhancing Low Back Pain Management: The Diagnostic and Prognostic Role of Single Photon Emission Computed Tomography-Computerized Tomography (SPECT-CT) in Surgical Outcomes.
  How specific active areas on Single Photon Emission Computed Tomography-Computerized Tomography (SPECT-CT) inform management for chronic low back pain (CLBP) is limited. This study aimed to assess the relationship between SPECT-CT uptake locations with spinope…
  pubmed Futch BG, Venkatraman V, OCallaghan E, Albanese J 等 2025 May 置信度 0.82
• The Interface of Additive Manufactured Tungsten-Diamond Composites.
  Tungsten-diamond metal matrix composites (MMCs) fabricated via L-PBF show potential for applications in nuclear facility shielding, heat sinks, precision cutting/grinding tools, and aerospace hot-end components. In this paper, tungsten (W), diamond (D), and di…
  pubmed Gao X, Cheng D, Sun Z, Huang Y 等 2025 May 30 置信度 0.82
• Mitochondrial Dysfunction in the Development and Progression of Cardiometabolic Diseases: A Narrative Review.
  Mitochondria play a central role in energy metabolism and continuously adapt through dynamic processes such as fusion and fission. When the balance between these processes is disrupted, it can lead to mitochondrial dysfunction and increased oxidative stress, c…
  pubmed Pliouta L, Lampsas S, Kountouri A, Korakas E 等 2025 May 25 置信度 0.82
• ROS-responsive death receptor 5 fusion protein nano-delivery system enhances myocardial ischemia-reperfusion injury protection.
  The microenvironment characterized by inflammation and oxidative stress plays a crucial role in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury. The death receptor 5 fusion protein (sDR5-Fc) specifically targets and blocks the key protein-tumo…
  pubmed Liang X, Zhang Y, Wang C, Li H 等 2025 Jun 置信度 0.82
• Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy.
  Mitochondrial abundance and genome are crucial for cellular function, with disruptions often associated with disease. However, methods to modulate these parameters for direct functional dissection remain limited. Here, we eliminate mitochondria from pluripoten…
  pubmed Schmitz DA, Oura S, Li L, Ding Y 等 2025 Aug 21 置信度 0.82
• Fungal syncytia.
  Eukaryotes are distinguished from prokaryotes by the presence of a nucleus. However, at some or all stages in their life cycle many fungal cells constitutively contain at least two nuclei in the same cytoplasm, resulting in a multinucleate 'coenocyte' (from th…
  pubmed Jalihal AP, Gladfelter AS 2025 Jun 9 置信度 0.82
• Precision-targeting and dual silencing osteoclastogenesis and inflammatory pathways for the treatment of radiation-induced bone deterioration.
  Ironizing radiation (IR)-induced bone loss remains a significant clinical challenge, largely driven by elevated osteoclastogenesis. Targeting key regulators of osteoclast differentiation and function may offer a novel therapeutic approach for preserving bone i…
  pubmed Luo G, Ma Y, Huang W, SiMa J 等 2025 Dec 置信度 0.82
• Advances in RARα fusion genes in acute promyelocytic leukemia.
  Retinoic acid receptor α (RARα) is a ligand-dependent transcription factor that dimerizes with retinoid X receptor α (RXRα) to activate target gene promoters, playing a critical role in normal hematopoiesis and granulocyte differentiati…
  pubmed Zhang A, Qiu S 2025 Sep 置信度 0.82