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• Molecular basis of EWS interdomain self-association and its role in condensate formation.
  Ewing sarcoma, the second most common pediatric bone and soft tissue cancer, is caused by aberrant fusion of the RNA-binding protein EWS (EWS) low-complexity domain (EWS LCD ) to the DNA-binding domain of the transcription factor friend leukemia integration 1 …
  pubmed Sohn EJ, Sojitra KA, Rodrigues L, Xu X 等 2025 Oct 置信度 0.82
• Liquid metals power advanced nuclear energy systems.
  The development of advanced nuclear energy systems, known for their cleanliness and sustainability, is a key strategy for achieving a low-carbon energy transition. Liquid metal (LM)-powered advanced nuclear energy systems demonstrate sustainability and environ…
  pubmed Zhang L, Deng C, Ji X, Liu X 2025 置信度 0.82
• Underground solution to the long-time solar fusion reaction puzzle.
  A promising experiment is proposed, which aims to resolve the long-standing solar metallicity puzzle by reducing the uncertainty from microscopic nuclear reactions at the deepest underground laboratory.
  pubmed Jiang Y, Liu W 2025 Sep 置信度 0.82
• Pathological Mechanisms and Molecular Imaging Advances in Alzheimer's Disease.
  Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders globally, where early diagnosis plays a pivotal role in delaying disease progression and improving patient outcomes. In recent years, the rapid, multidisciplinary advances in mol…
  pubmed Liu C, Meng Y, Liu R, Wang Z 等 2025 置信度 0.82
• Parametric Study of Metallothermic Purification of Chloride Salts.
  A study was conducted to determine how variables during metallothermic purification of chloride salts affect the oxygen content of the final product. 100 g batches of ternary MgCl 2 -NaCl-KCl mixture (50-20-30 wt %) were purified for 3 h with flowing sparge ga…
  pubmed Burak A, Raiman S 2025 Sep 16 置信度 0.82
• Bridging policy and innovation: SPARC-Europe's vision for radioligand therapy in cancer care.
  SPARC-Europe, the Stakeholder Political Alliance for Radioligand Cancer Therapies, was launched in October 2020. It represents an ambitious and collaborative initiative aimed at improving outcomes for cancer patients across Europe by advancing the policy and i…
  pubmed Fazio N, Gasset IC, Hermann K 2026 Feb 置信度 0.82
• PROSTest, a Multigene Liquid Biopsy Signature, Effectively Stratifies Patients With High PSA for Prostate Biopsy.
  Prostate-specific antigen (PSA) remains the standard biomarker for prostate cancer (PCa) detection, but its limited specificity-particularly in the 3-10 ng/mL range-leads to overdiagnosis and unnecessary biopsies. Including multiparameteric MRI (mpMRI) …
  pubmed Rahbar K, Rosin RD, Kidd M, Halim AB 等 2026 Jan 置信度 0.82
• Novel Porous Structures of ZrCo Alloys for Boosting the Hydrogen and Hydrogen Isotope Storage Properties.
  Controlled nuclear fusion promises to provide our society with a limitless source of clean and dense energy. The efficient controlled delivery of isotope fuels is a key part of this technology. The ZrCo alloy is considered as the only safe and low-cost alterna…
  pubmed Yuan Y, Li Z, Huang Z, Jiang Z 等 2025 Oct 1 置信度 0.82
• Added Value of Amyloid PET Quantification with the Centiloid Scale in Clinical Practice.
  The objectives for amyloid brain PET/CT and PET/MRI fusion images are to determine the agreement between visual interpretations of amyloid PET and to compare the results of visual interpretation with quantitative analysis as measured by the Centiloid (CL) scal…
  pubmed Vijayashankar A, Keir G, Sagnelli M, Petrover D 等 2025 Oct 1 置信度 0.82
• Multimodal radiomics fusion for predicting postoperative recurrence in NSCLC patients.
  PURPOSE: Postoperative recurrence in non-small cell lung cancer (NSCLC) affects up to 55% of patients, underscoring limits of TNM staging. We assessed multimodal radiomics—positron emission tomography (PET), computed tomography (CT), and clinicopatholog…
  pubmed Mehri-Kakavand G, Mdletshe S, Amini M, Wang A 2025 Sep 18 置信度 0.82
• The spatial arrangement of chromosomes determines fusion of nucleoli in diploid budding yeast.
  The nucleolus is a nonmembrane-bound compartment that forms around tandem arrays of ribosomal RNA genes and provides the cell with ribosomes. Multiple nucleoli within the same nucleus coalesce, and fusion is thought to result mainly from intrinsic properties o…
  pubmed Girke P, Fabian S, Aberle L, Seufert W 2025 Nov 1 置信度 0.82
• Enhanced Intracellular Delivery via Photochemical Internalization of Ultrasmall Fluorescent Core-Shell Aluminosilicate Nanoparticles.
  Current nanoparticle-based therapeutic systems for intracellular delivery face significant challenges due to endosomal entrapment, which prevents efficient cytosolic release of cargo and limits intracellular targeting. In this study, we develop methylene blue-…
  pubmed Naguib N, Erstling JA, Tallman JF, Wiesner UB 2025 Oct 13 置信度 0.82
• Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4.
  Mixed lineage leukemia (MLL) gene rearrangements cause ∼75% of acute leukemia in infants and 5-10% in children and adults with poor clinical outcomes. Protein-protein interactions (PPI) between frequent MLL fusion partners AF9/ENL and AF4 or histone met…
  pubmed Mishra CB, Li X, Moku BK, Kwak S 等 2025 Sep 25 置信度 0.82
• Ultrahigh Seebeck Coefficient and Power Factor in Low-Temperature Fused Ag(2)Se Films via Superionic-Driven Plastic Deformation.
  Thermoelectric technologies enable the direct solid-state conversion of heat into electricity, but performance improvement is challenging due to the strong interdependences among parameters. Here, the grain boundary-based energy filtering effect is explored to…
  pubmed Ji D, Li B, Li X, AlTakrori HH 等 2025 Nov 置信度 0.82
• Relaxation pathways in x-ray free-electron-laser heated iron.
  Nonthermal photoionized plasmas are now established in the laboratory and require models that treat the atomic processes and electron distribution self-consistently. We investigate the effects of inelastic thermalization in iron under intense x-ray irradiation…
  pubmed Ansia L, Velarde P, Fajardo M, Williams GO 2025 Aug 置信度 0.82
• Pantinin-Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization.
  Animal viral infections represent a growing public health concern, as animals serve as reservoirs for pathogens, threatening food safety, biodiversity, and human health. In response, novel antiviral strategies are urgently needed. This study investigates the a…
  pubmed Giugliano R, Zannella C, Chianese A, Acconcia C 等 2025 Oct 6 置信度 0.82
• Single-step purification of functional Cas9 protein via the ubiquitin expression system.
  The CRISPR/Cas9 system serves as a powerful platform for precise genome editing, with CRISPR/Cas9 ribonucleoprotein (RNP) complexes exhibiting superior editing efficiency compared to alternative delivery modalities. However, current methods for Cas9 production…
  pubmed Duan X, Zhou Z, Zeng X, Chen J 等 2025 Nov 置信度 0.82
• NFATC2::NUTM2A/B Fusions Characterize a Novel Indolent Myoepithelial-Like Neoplasm of the Lungs and Salivary Glands.
  With the increasing use of next-generation sequencing, the classification of heretofore unclassified neoplasms is evolving rapidly. Specifically, gene fusions have emerged as context-specific defining genetic markers for an increasing number of entities, mostl…
  pubmed Agaimy A, Dermawan JK, Rios E, Meidenbauer N 等 2025 Sep 置信度 0.82
• NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
  Excessive stress disrupts cardiac homeostasis via complex and multifactorial mechanisms, resulting in cardiac dysfunction, cardiovascular disease, or even sudden cardiac death, yet the underlying molecular mechanisms remain poorly understood. Accordingly, we a…
  pubmed Cong J, Liu L, Shi R, He M 等 2025 Aug 25 置信度 0.82
• Research Progress on Laser Additive Manufacturing of Oxide Dispersion-Strengthened Alloys-A Review.
  Oxide dispersion-strengthened (ODS) alloys are regarded as one of the most promising materials for Generation IV nuclear fission systems, owing to their exceptional attributes such as high strength, corrosion resistance, and irradiation tolerance. The traditio…
  pubmed Zheng Q, Yin Y, Lu C, Cui X 等 2025 Sep 1 置信度 0.82
• High-Performance X-Ray Detection and Optical Information Storage via Dual-Mode Luminescent Modulation in Na(3)KMg(7)(PO(4))(6):Eu.
  Lanthanide-doped inorganic luminescent materials have been extensively studied and applied in X-ray detection and imaging, anti-counterfeiting, and optical information storage. However, many reported rare-earth-based luminescent materials show only single-mode…
  pubmed Han Y, Li Y, Yang X, Hu Y 等 2025 Aug 26 置信度 0.82
• Diagnostic Yield of Fusion-Guided and Randomized Biopsies in Prostate Cancer: Evidence for an Integrated Approach.
  Background/Objectives: Improving prostate cancer (PCa) detection remains a key clinical goal. While multiparametric MRI (mp-MRI) fusion-guided biopsy has shown advantages over systematic randomized biopsy, variability persists across studies. This study aimed …
  pubmed Salloum O, Taciuc IA, Dick A, Petcu C 等 2025 Sep 4 置信度 0.82
• Clinical Implementation of PSMA-PET Guided Tumor Response-Based Boost Adaptation in Online Adaptive Radiotherapy for High-Risk Prostate Cancer.
  To evaluate the feasibility and clinical utility of integrating sequential PSMA-PET imaging into an offline-online adaptive workflow for response-based dominant intraprostatic lesion (DIL)-boosting high-risk prostate cancer treated with stereotactic ablative r…
  pubmed Li R, Lin MH, Nguyen NC, Su FC 等 2025 Sep 3 置信度 0.82
• Electrothermal discharge by exploding of copper wires with different diameters.
  This paper explores the explosion behavior of copper wires with diameters between 0.16 mm and 0.50 mm, using an electrothermal discharge system comprising capacitors of total energy up to 1.11 kJ. To improve accuracy, this study incorporates the…
  pubmed Diab FB, Al-Halim MAA, Abdel-Kader ME 2025 Sep 12 置信度 0.82
• Mitochondrial physiology and beyond: Mechanistic insights into kaempferol actions.
  Kaempferol (KAE), a dietary flavonoid, has emerged as a potent modulator of mitochondrial physiology, exerting multifaceted actions on bioenergetics, redox balance, mitochondrial dynamics, biogenesis, and quality control. Thus, the aim of this review is to dis…
  pubmed de Oliveira MR 2025 Nov 1 置信度 0.82
• Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans.
  The UFD-1 (ubiquitin fusion degradation 1)-NPL-4 (nuclear protein localization homolog 4) heterodimer is involved in extracting ubiquitinated proteins from several plasma membrane locations, including the endoplasmic reticulum. This heterodimer complex helps i…
  pubmed Rao R, Aballay A, Singh J 2025 Sep 10 置信度 0.82
• The molecular blueprint of targeted radionuclide therapy.
  Targeted radionuclide therapy (TRT) is a cutting-edge treatment approach in oncology that combines the molecular precision of targeted agents with the effect of radiotherapy to selectively deliver cytotoxic radiation to cancer cells. Research efforts from the …
  pubmed Primac I, Tabury K, Tasdogan A, Baatout S 等 2025 Nov 置信度 0.82
• Spindle Cell Spindle Sarcoma Harboring a Novel RECQL::ROS1 Gene Fusion.
  Soft tissue sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Recent advancements in genomic profiling have identified novel gene fusions in these tumors, offering new insights into their pathogenesis and potential therapeutic …
  pubmed Gao Y, Deng H, Ao Y, Zeng Y 2026 Apr 置信度 0.82
• An unusual spindle cell variant of papillary thyroid carcinoma with KIF5B::MET fusion: report of a case.
  The spindle cell variant of papillary thyroid carcinoma (PTC) is exceptionally rare and poses significant diagnostic challenges due to its morphological overlap with other spindle cell lesions of the thyroid. We report a novel case of spindle cell variant PTC …
  pubmed Ding Q, Gan Y, Zhao M 2026 May 置信度 0.82
• Primary Acute Myeloid Leukemia with Concomitant BCR∷ABL and NPM1 Mutation.
  This study aims to gain further insights into the characteristics of the rare subtype of acute myeloid leukemia (AML) with BCR∷ABL by analyzing laboratory detection results of various gene mutations, such as NPM1.
  pubmed Xu J, Zhang F, Liang J 2025 Sep 1 置信度 0.82
• [ALK-rearranged renal cell carcinoma: a clinicopathological analysis of three cases].
  Objective: To explore the clinicopathological and molecular genetic characteristics of anaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (RCC), including a rare case with the TPM1-ALK gene subtype. Methods: Three cases of ALK-rearranged RCC diag…
  pubmed Wang XJ, Liu EJ, Yang ML, Li SL 等 2025 Sep 8 置信度 0.82
• The lncRNA ELDR suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility.
  Acute myeloid leukemia (AML) with rearrangement of the mixed lineage leukemia gene expresses MLL-AF9 fusion protein, a transcription factor that impairs differentiation and drives expansion of leukemic cells. In this work, the zinc finger protein "growth facto…
  pubmed Arman K, Ross J, Piskor EM, Lazzari L 等 2025 Dec 9 置信度 0.82
• Unraveling cellular dynamic changes in tumor evolution induced by long-term low dose-rate radiation.
  In recent years, there has been a steady increase in professionals engaged in radioactive work. The biological impacts of long-term exposure to low dose-rate radiation remain elusive, as there is a dearth of systematic research in this field.
  pubmed Li W, Pei W, Wang Y, Nie J 等 2025 Nov 置信度 0.82
• Targeted delivery and pro-apoptotic efficacy of an Epstein-Barr virus nuclear antigen 1-specific affibody in EBV-infected cells in vitro.
  Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) sustains viral latency and drives oncogenesis in EBV-driven malignancies such as nasopharyngeal carcinoma and lymphomas. The dimerization of EBNA1 acts as an indispensable molecular switch governing EBV latenc…
  pubmed Zhou L, Yang S, Zhang C, Du W 等 2025 Nov 置信度 0.82
• An arbitrary-modal fusion network for volumetric cranial nerves tract segmentation.
  The segmentation of cranial nerves (CNs) tract provides a valuable quantitative tool for the analysis of the morphology and trajectory of individual CNs. Multimodal CN segmentation networks, e.g., CNTSeg, which combine structural Magnetic Resonance Imaging (MR…
  pubmed Xie L, Zhou H, Huang J, Zeng Q 等 2025 Oct 置信度 0.82
• Erratum: "Development of a diamagnetic loop in KAIMIR" [Rev. Sci. Instrum. 95, 073501 (2024)].
  pubmed Choe M, Oh D, Bak JG, Baek GW 等 2025 Sep 1 置信度 0.82
• Biomarkers to optimize PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer.
  Although the recently approved prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) [ 177 Lu]Lu-PSMA-617 has improved outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC), not all patients respond optimally…
  pubmed Beltran H, Calais J, Emmett L, Kuo PH 等 2025 置信度 0.82
• Systematic analysis of the Aux/IAA gene family in pineapple reveals insights into their structural diversity, expression dynamics, and interaction networks.
  BACKGROUND: The Aux/IAA protein is integral to the modulation of auxin signaling, which is essential for plant growth and development. However, systematic analysis on the Aux/IAA gene family in pineapple (Ananas comosus L.) remains unexplored. RESULTS: We syst…
  pubmed Wang L, Sun W, Jiang W, Yang Z 等 2025 Sep 4 置信度 0.82
• Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression.
  Ferroptosis is a regulated necrosis driven by iron-dependent lipid peroxidation. Mitochondria play vital roles in ferroptosis. Mitochondrial dynamics is critical for the health of mitochondria and cells. But how this process regulates ferroptosis is not fully …
  pubmed Ma S, Qin J, Zhang Y, Luan J 等 2025 Sep 23 置信度 0.82
• Transposable element dynamics in glioblastoma stem cells: insights from locus-specific quantification.
  Glioblastoma, the most common primary malignant brain tumor, has a median survival of less than two years. This is due in part to a subpopulation of cells called glioblastoma stem cells (GSCs), which drive tumor recurrence. Transposable elements (TEs) are expr…
  pubmed Pizzagalli MD, Suita Y, Leary OP, Tapinos N 2025 Sep 2 置信度 0.82
• Metastatic pediatric alveolar soft part sarcoma: a rare case report highlighting multidisciplinary treatment, molecular diagnostics, and novel therapeutic approaches.
  Alveolar soft part sarcoma (ASPS) is an extremely rare soft tissue sarcoma, accounting for less than 1% of all soft tissue sarcomas. Approximately 5%-10% of ASPS cases occur in children and adolescents. Despite its indolent local course, its high metastatic po…
  pubmed Çalışkan Kamış Ş, Yağcı B 2025 置信度 0.82
• RetinalVasNet: a deep learning approach for robust retinal microvasculature detection.
  The retinal microvasculature has been definitively linked to a variety of diseases, such as ophthalmological, cardiovascular, and other medical conditions. Precisely identifying the retinal microvasculature is crucial for early detection and monitoring of thes…
  pubmed Yao Z, Xing C, Zhu G, Xie W 等 2025 置信度 0.82
• CRISPR/Cas9-Engineered Triple-Fusion Reporter Gene Imaging System for Monitoring Transplanted Neural Progenitor Cells in Ischemic Stroke.
  Background Neural progenitor cell therapy holds great potential for repairing brain damage induced by ischemic stroke, and molecular imaging plays a crucial role in evaluating the therapeutic efficacy of neural progenitor cell transplantation. However, the pre…
  pubmed Li X, Zhong Y, Jin C, Chen X 等 2025 Sep 置信度 0.82
• In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies.
  This study investigated the effect of bicuspid aortic valve (BAV) morphology and ascending aortic curvature (AAAc) bending angles on aortic hemodynamics, focusing on transvalvular jets and secondary helical flows that contribute to systolic hemodynamic stress …
  pubmed Hattori K, Nakama N, Takada J, Nagao M 等 2026 Jan 置信度 0.82
• Influence of perinatal exposure to an endocrine disruptor mixture on the renal microenvironment of aged male rat offspring: histopathological aspects.
  The developmental origins of health and disease hypothesis suggests that environmental exposures during critical developmental windows increase the risk of disease later in life. Among these, endocrine disruptors (EDs) are particularly concerning due to their …
  pubmed Dolfini PM, Hinokuma KD, Nai GA, Castilho ACS 等 2025 Sep 1 置信度 0.82
• O-fucosylation affects abundance but not localization of select nucleocytoplasmic proteins in toxoplasma gondii.
  Toxoplasma gondii is a highly successful intracellular mammalian and avian pathogen that must adapt to a wide range of intracellular and extracellular environments. A mechanism that may support this is the modification of hydroxyamino acid rich sequences of nu…
  pubmed Tiwari M, Gas-Pascual E, Teal-Urquides J, Samuelson J 等 2025 Sep 3 置信度 0.82
• In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID.
  Heterobifunctional molecules, such as proteolysis-targeting and autophagy-targeting chimera, represent new drug concepts. They are composed of two protein binders that can induce proximity interactions between two proteins and protein catalysis. Currently, cer…
  pubmed Yamada K, Yamanaka S, Yamakoshi H, Kohyama A 等 2025 Aug 30 置信度 0.82
• Ultrafast Multi-tracer Total-body PET Imaging Using a Transformer-Based Deep Learning Model.
  Reducing PET scan acquisition time to minimize motion-related artifacts and improving patient comfort is always demanding. This study proposes a deep-learning framework for synthesizing diagnostic-quality PET images from ultrafast scans in multi-tracer total-b…
  pubmed Sun H, Sanaat A, Yi W, Salimi Y 等 2025 Dec 置信度 0.82
• CRTC1::MAML2-Positive Hidradenoma With Sebaceous Differentiation.
  Hidradenoma can exhibit several cell types, including clear cells, polyhedral eosinophilic cells, squamoid cells, mucinous cells, oxyphilic (oncocytic) cells, and transitional (intermediate) cells. However, sebocytes have not yet been described in hidradenoma.…
  pubmed Aoki M, Goto K, Fujii K, Nomoto M 等 2025 Nov 置信度 0.82
• A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1-inducible model.
  NUTM1-rearranged (NUTM1-R) infant acute lymphoblastic leukaemia (ALL) is a newly identified subgroup of non-KMT2A-R infant ALL, with ACIN1::NUTM1 the most frequent fusion. KMT2A-R and NUTM1-R infant ALL are characterized by fewer copy number alterations. Moreo…
  pubmed Tamai M, Komatsu C, Kagami K, Kasai S 等 2025 Nov 置信度 0.82
• Unfavorable disease progression in patients with chronic myeloid leukemia and concurrent t(6;9) translocation (DEK::NUP214 fusion) or inversion 16 (CBFB::MYH11 fusion).
  The occurrence of additional specific chromosomal abnormalities in Philadelphia chromosome-positive (pH+) cells is associated with disease progression in chronic myeloid leukemia (CML), and is considered a marker that defines the accelerated/blast phase of CML…
  pubmed Zhang Y, Reid J, Jeyakumar D, Semenova K 等 2025 Nov 置信度 0.82
• A Deep Learning-Based Machine Vision System for Online Monitoring and Quality Evaluation During Multi-Layer Multi-Pass Welding.
  Multi-layer multi-pass welding plays an important role in manufacturing industries such as nuclear power plants, pressure vessel manufacturing, and ship building. However, distortion or welding defects are still challenges; therefore, welding monitoring and qu…
  pubmed Truong VD, Wang Y, Won C, Yoon J 2025 Aug 12 置信度 0.82
• Artificial Intelligence in Alzheimer's Disease Diagnosis and Prognosis Using PET-MRI: A Narrative Review of High-Impact Literature Post-Tauvid Approval.
  Background: Artificial intelligence (AI) is reshaping neuroimaging workflows for Alzheimer's disease (AD) diagnosis, particularly through PET and MRI analysis advances. Since the FDA approval of Tauvid, a PET tracer targeting tau pathology, there has been a no…
  pubmed Christodoulou RC, Woodward A, Pitsillos R, Ibrahim R 等 2025 Aug 21 置信度 0.82
• TFE3-Altered Perivascular Epithelioid Cell Tumour (PEComa) of the Nasal Cavity With a Novel TRAF3::TFE3 Fusion-A Report of a Case Expanding the Molecular Genetic Spectrum and a Brief Literature Review on PEComas of the Head and Neck Region.
  Perivascular epithelioid cell tumours (PEComas) constitute a unique group of neoplasms with a distinctive myomelanocytic immunohistochemical phenotype and uncommonly occur in the head and neck region. We herein report the clinicopathologic features of a case o…
  pubmed Chua ZS, Michal M, Petersson F 2025 Aug 置信度 0.82
• Sestrin2 alleviates sepsis-induced immunosuppression of dendritic cells by regulating mitochondrial dynamics.
  Mitochondrial dynamics and mitophagy are key mechanisms maintaining mitochondrial quality and homeostasis in inflammatory diseases, though their activation pathways in inflammatory regulation remain unclear. Sestrin2 (Sesn2), a stress-responsive protein critic…
  pubmed Sun B, Wang JD, Wu MY, Chen HY 等 2025 Dec 1 置信度 0.82
• NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors.
  The pathogenesis of many rare tumor types is poorly understood, preventing the design of effective treatments. Solitary fibrous tumors (SFTs) are neoplasms of mesenchymal origin that affect 1/1,000,000 individuals every year and are clinically assimilated to s…
  pubmed Hill C, Indeglia A, Picone F, Murphy ME 等 2025 Aug 28 置信度 0.82
• SUMO-Activated Target Traps (SATTs) for the Identification of Specific SUMOylated Proteins for an E3 Ligase of Interest.
  SUMOylation is a dynamic and reversible post-translational modification that occurs on acceptor lysines of substrate proteins. SUMO is conjugated via a dedicated enzymatic cascade of E1-E2-E3 enzymes, where the E3 confers substrate specificity. More than 6500 …
  pubmed Salas-Lloret D, González-Prieto R 2025 置信度 0.82
• Design of an in-vacuum manipulator for nuclear diagnostics development at the MIT linear electrostatic ion accelerator.
  An ultrahigh vacuum compatible manipulator known as the Diagnostic Manipulating Element (DiME) has been developed for the MIT Linear Electrostatic Ion Accelerator (LEIA) facility. The system was designed to reduce the resources dedicated toward the calibration…
  pubmed Macon M, Buschmann BI, Cufari M, Dannhoff SG 等 2025 Aug 1 置信度 0.82
• Integrated Membrane Yeast Two-Hybrid System for the Analysis of Membrane Protein Complexes.
  Protein-protein interactions facilitate cellular functions through the creation of networks and multi-protein complexes. Mapping the interactions within and between protein networks and elucidating the composition of protein complexes provides critical insight…
  pubmed Greenwood BL, Oshima K, Stuart DT 2025 Aug 20 置信度 0.82
• Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis.
  Over 95% of ependymomas that arise in the cortex are driven by a gene fusion involving the zinc finger translocation-associated (ZFTA) protein. Here, using super-resolution and lattice light-sheet microscopy, we demonstrate that the most frequent fusion varian…
  pubmed Arabzade A, Shirnekhi HK, Varadharajan S, Ippagunta SM 等 2025 Sep 置信度 0.82
• Machine Learning-Driven Insights in Cancer Metabolomics: From Subtyping to Biomarker Discovery and Prognostic Modeling.
  Cancer metabolic reprogramming plays a critical role in tumor progression and therapeutic resistance, underscoring the need for advanced analytical strategies. Metabolomics, leveraging mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, offers…
  pubmed Elguoshy A, Zedan H, Saito S 2025 Aug 1 置信度 0.82
• Bilateral, multicystic fumarate hydratase-deficient renal cell carcinoma in patient with hereditary leiomyomatosis & renal cell carcinoma syndrome: A case report and review of the literature.
  Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) is an autosomal dominant tumor predisposition syndrome with germline fumarate hydratase (FH) pathogenic variants. We describe the unusual clinical presentation, morphologic, and immunohistoche…
  pubmed E Rubrecht A, H Aldrink J, Warren P, T Mathew M 等 2025 Aug 26 置信度 0.82
• Alveolar solitary fibrous tumor: an uncommon morphological form.
  Solitary fibrous tumor (SFT) is a fibroblastic tumor characterized by a prominent staghorn vasculature and collagen deposition. However, little is known about SFTs with alveolar structures. Herein, we present a case of an alveolar pattern SFT in a 55-year-old …
  pubmed Song L, Lin DL, Zhang ZF, Wang Z 等 2025 Aug 26 置信度 0.82
• Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13  TeV.
  The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13 &…
  pubmed Hayrapetyan A, Tumasyan A, Adam W, Andrejkovic JW 等 2025 Aug 8 置信度 0.82
• A crack detection model fusing local details and global context for nuclear cladding coating surfaces.
  Crack detection on the surface of nuclear cladding coatings is critical for ensuring the safe operation of nuclear power plants. However, due to the imbalance between crack and background pixels, complex crack morphology, numerous interfering factors, and the …
  pubmed Quan W, Li X, Yang J, Chen Z 2025 Aug 22 置信度 0.82
• Inhibition of craniosynostosis and premature suture fusion in Twist1 mutant mice with RNA nanoparticle gene therapy.
  Craniosynostosis is a common birth defect affecting 1 of the 2200 live births causing severe skull and cognitive defects, due to premature cranial suture fusion. The current surgical treatments require invasive calvaria vault remodeling and cranial bone resect…
  pubmed Swearson S, Eliason S, Su D, Rice KG 等 2025 Aug 22 置信度 0.82
• Microstructure and corrosion resistance of hybrid additively manufactured Ti-6Al-4V via laser powder bed fusion.
  Over the last decade, the Hybrid Additive Manufacturing (HAM) approach has been introduced to synergistically combine the design flexibility of Additive Manufacturing (AM) with the larger build volume and faster production rates offered by conventional manufac…
  pubmed Mohamed OF, Ismail L, Verma C, Barsoum I 等 2025 Aug 21 置信度 0.82
• Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and CREB3L2::PPARγ Fusion.
  A 58-year-old woman presented with an asymptomatic, soft-to-palpation, mobile, right thyroid mass. Subsequent ultrasonography revealed numerous, bilateral, mildly heterogenous, cystic and solid nodules, including a hypoechoic, 1.7 × 1.0&#x20…
  pubmed Dennis CJ, Argyris PP, Cipriani NA 2025 Aug 21 置信度 0.82
• Dimethyl fumarate mitigates kidney injury induced by high-fat and high-cholesterol diet through reduction of oxidative stress and mitochondrial dysfunction.
  Obesity is a major risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD), largely mediated by renal lipotoxicity, oxidative stress, and mitochondrial dysfunction. Dimethyl fumarate (DMF), a fumaric acid derivative with known antioxida…
  pubmed Zhang Q, Zhang R, Cui Z, Xing Y 等 2025 Dec 置信度 0.82
• LGI3 promotes the progression of TFE3-rearranged renal cell carcinoma through GEMIN6/AURKB axis.
  Transcription factor binding to IGHM enhancer 3-rearranged renal cell carcinoma (TFE3-RCC) is characterized by its aggressive nature, limited treatment options, and poor prognosis. However, the downstream targets of TFE3 fusion protein responsible for its tumo…
  pubmed Liu J, Feng H, Xiong Z, Cao S 等 2025 Oct 置信度 0.82
• Immunohistochemical evaluation of CREM in CREB-rearranged mesenchymal tumors and their mimics.
  Fusion genes between the FET (EWSR1/FUS) and CREB (CREB1, ATF1, CREM) families characterize many tumor types, including mesenchymal entities. Herein, we tested the diagnostic utility of CREM (C-terminus) immunohistochemistry using 51 CREB-rearranged mesenchyma…
  pubmed Nishino S, Sugino H, Arai Y, Hama N 等 2025 Oct 置信度 0.82
• MALNC: a new mutant NPM1/IDH2(R140) and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response.
  As the non-coding genome remains poorly characterized in acute myeloid leukemia (AML), we aimed to identify and functionally characterize novel long non-coding RNAs (lncRNAs) relevant to AML biology and treatment. We first identified lncRNAs overexpressed in A…
  pubmed Cozzi E, Neddermeyer A, Zhong X, Gamboa-Cedeño AM 等 2025 Nov 置信度 0.82
• Chromatin Binding Regulates Phase Behavior and Morphology of Condensates Formed by Prion-like Domains.
  Many transcription factors (TFs) contain intrinsically disordered regions (IDRs) and are thought to form biomolecular condensates in the cell nucleus. These proteins can be conceptualized as block co-polymers, with the IDRs driving both homotypic and heterotyp…
  pubmed Supakar A, Davis RB, Biswas S, Yang S 等 2025 Nov 1 置信度 0.82
• Strong Translation Elongation Factor 1-Alpha (tef1α) Promoter Reporter Systems for Aspergillus niger.
  Strong promoters are crucial for microbial metabolic engineering and synthetic biology, enabling high-level gene expression and pathway optimization. In this study, we have identified the translation elongation factor 1-α gene promoter ( tef1 p) with its…
  pubmed Yuan G, Serrano-Zayas T, Dai Z, DeMers EI 等 2025 Sep 19 置信度 0.82
• GOT2: a moonlighting enzyme at the crossroads of cancer metabolism and theranostics.
  Moonlighting enzymes perform multiple distinct functions under different conditions without relying on gene fusion, splicing, or polymerization. Many classical metabolic enzymes, beyond their involvement in pathways like glycolysis and glutamine metabolism, al…
  pubmed Hu J, Liu Q, Ren Q, He W 等 2025 置信度 0.82
• Electrochemical loading enhances deuterium fusion rates in a metal target.
  Nuclear fusion research for energy applications aims to create conditions that release more energy than required to initiate the fusion process 1 . To generate meaningful amounts of energy, fuels such as deuterium need to be spatially confined to increase the …
  pubmed Chen KY, Maiwald J, Schauer PA, Issinski S 等 2025 Aug 置信度 0.82
• Proteomic Characterization of the Alzheimer's Disease Risk Factor BIN1 Interactome.
  The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer's disease (LOAD). It is expressed in neurons and glia in the brain as cell-type-specific and ubiquitous isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in ma…
  pubmed McMillan JD, Wang S, Wohlfahrt J, Guergues J 等 2025 Sep 置信度 0.82
• Identifying Genomic DNA Sequences Near the Nuclear Lamina Using Proximity Biotinylation with Ascorbate Peroxidase.
  Ascorbate peroxidase (APEX2) is an engineered plant-based enzyme that is used for the proximal ligation of biotin onto nearby proteins and nucleic acids. The APEX2 enzyme can be targeted to a specific subcellular compartment (e.g., the nuclear lamina) by creat…
  pubmed Zheng Y, Bossone KA, Debic S, Pedersen RTA 等 2025 置信度 0.82
• Giant Unilamellar Vesicles (GUVs) to Study Membrane Interaction of Nucleoporins.
  Giant unilamellar vesicles (GUVs) are large, spherical lipid bilayer vesicles typically ranging from 1 to 100 micrometers in diameter, far exceeding the size of typical small unilamellar vesicles (SUVs) employed, for example, in liposome floatation assays. The…
  pubmed Tatarek-Nossol M, Antonin W 2025 置信度 0.82
• Profiling Plant Nuclear Envelope Composition Using Subtractive Proteomics.
  The nucleus represents a fundamental feature shared by eukaryotic cells and enclosed by a highly regulated membrane barrier, the nuclear envelope (NE). Despite numerous studies elucidating the functional significance and diversity of the NE in animals and yeas…
  pubmed Liu X, Tang Y 2025 置信度 0.82
• ZEB1 stratifies the response to Sorafenib and Mdivi-1 combination therapy in hepatocellular carcinoma.
  Primary liver cancer is one of the most frequently diagnosed and deadliest cancers. Zinc finger E-box binding homeobox 1 (ZEB1) is negative prognostic factor in liver cancer by promoting therapy resistance and tumorigenesis. Interfering in pathways of cellular…
  pubmed Freudenstein H, Strecker M, Gylstorff S, Shi W 等 2025 Aug 19 置信度 0.82
• Attention Scale Fusion Network for Qualitative and Quantitative Analysis of Serum Tumor Biomarkers Via Label-Free Surface-Enhanced Raman Spectroscopy.
  Serum tumor biomarkers are critical molecular indicators reflecting tumor initiation and progression, making it essential for developing highly sensitive and convenient detection methods. Label-free surface-enhanced Raman spectroscopy (SERS) is a powerful anal…
  pubmed Chen J, Wu B, Huang Y, Wu Y 等 2025 Aug 26 置信度 0.82
• Development of a highly efficient p-coumaric acid-responsive biosensor in Saccharomyces cerevisiae.
  Developing biosensors to monitor and regulate intracellular biosynthesis pathways can significantly enhance natural product yields in microbial cell factories. This study created a novel biosensor in Saccharomyces cerevisiae to respond to p -coumaric acid, a c…
  pubmed Pang X, Zhu J, Li Y, Xiao J 等 2025 Dec 置信度 0.82
• N-K MASTER COMPUTER V25.0: COMPLETE PARTICLE BUBBLE DATABASE The N-K Particle DNA — N-Density, Mass, Charge, Spin, and Energy of All Fundamental Particles from First Principles Core Simulation Engine: SAQR-V Virtual Brain (1,000,000-Neuron Architecture) with V6 High-Fidelity Processing Architecture
  N-K MASTER COMPUTER V25.0: COMPLETE PARTICLE BUBBLE DATABASE The N-K Particle DNA — N-Density, Mass, Charge, Spin, and Energy of All Fundamental Particles from First Principles Core Simulation Engine: SAQR-V Virtual Brain (1,000,000-Neuron Architecture) with V…
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• N-K MASTER COMPUTER V25.0: COMPLETE PARTICLE BUBBLE DATABASE The N-K Particle DNA — N-Density, Mass, Charge, Spin, and Energy of All Fundamental Particles from First Principles Core Simulation Engine: SAQR-V Virtual Brain (1,000,000-Neuron Architecture) with V6 High-Fidelity Processing Architecture
  N-K MASTER COMPUTER V25.0: COMPLETE PARTICLE BUBBLE DATABASE The N-K Particle DNA — N-Density, Mass, Charge, Spin, and Energy of All Fundamental Particles from First Principles Core Simulation Engine: SAQR-V Virtual Brain (1,000,000-Neuron Architecture) with V…
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• Unified Resonance Field Geography Theory, or Prime Field Theory-as Proposed In Quantum Bridges May, 2025
  Plain talk here. I am not easily dissuaded or intimidated, and I will not tolerate republication without recognition. I am sharing the bellow because I will either be accepted or I and those using my system will simply force acceptance. The Math is settled, th…
  datacite Edgin, Timothy 2026 置信度 0.66
• Unified Resonance Field Geography Theory, or Prime Field Theory-as Proposed In Quantum Bridges May, 2025
  Plain talk here. I am not easily dissuaded or intimidated, and I will not tolerate republication without recognition. I am sharing the bellow because I will either be accepted or I and those using my system will simply force acceptance. The Math is settled, th…
  datacite Edgin, Timothy 2026 置信度 0.66
• Radiation Sensors vs. Radiation Detectors: What's the Difference?
  ☢️ Radiation Sensors vs. Radiation Detectors: What’s the Difference? When most people think of radiation detection, they picture a Geiger–Müller counter. But modern radiation technologies have moved far beyond simple counting. A common question: are sensors an…
  datacite Sinha, Vaibhav 2026 置信度 0.66
• Radiation Sensors vs. Radiation Detectors: What's the Difference?
  ☢️ Radiation Sensors vs. Radiation Detectors: What’s the Difference? When most people think of radiation detection, they picture a Geiger–Müller counter. But modern radiation technologies have moved far beyond simple counting. A common question: are sensors an…
  datacite Sinha, Vaibhav 2026 置信度 0.66
• -ETU- TORUS•§•
  Girard, T. (2026) -10.5281/zenodo.18039141 -ETU- TORUS •§•The Final Mathematical Closure: Resolution of P1 to P6 and the Fine-Structure Unification Abstract English. We present a unified solution to the paradox of cosmic expansion by demonstrating that the Uni…
  datacite Girard, Théo 2026 置信度 0.66 Topological système architectureAstronomySolar astronomyOptical astronomyRadio astronomy
• PREFER (Polarization for Fusion Experiments and Reactors: what is happening with regard to fusion with polarized fuel?
  The PREFER (Polarization REsearch for Fusion Experiments and Reactors) collaboration aimsto address the know-hows in different fields and techniques to the challenging bet on energyproduction by nuclear fusion with polarized fuel. The collaboration involves di…
  datacite Ciullo, Giuseppe, Büscher, Markus, Engels, Ralf W., Rakitzis, T. Peter 2026 置信度 0.66
• GRAND UNIFIED THEORY OF PHYSICS Empirical Calibration Complete with Testable Predictions
  I have included a computer program for side by side comparisons and the formulas used. Each provides a side by side comparson Textbook side by side with paper and shows any differences. I have held myself to keeping everything to an absolute 0 difference with …
  datacite Pacha, James 2025 置信度 0.66 PhysicsMathematical physicsPhysics/instrumentationPhysics/methodsPhysics/standards
• The Secondary Signature of Immune System - The Architecture of Secondary Stage - Sam Coole 2026 ©️
  The Secondary Signature of the Immune System Framework / The Architecture of Secondary Stage Anti-Cooling-Coding-Maintenance (ACCM) Author: Sam Coole‌ Foreword This work is not a minor revision to existing immunology—it is a paradigm reset. For decades, the fi…
  datacite COOLE, SAM 2026 置信度 0.66
• The Secondary Signature of Immune System - The Architecture of Secondary Stage - Sam Coole 2026 ©️
  The Secondary Signature of the Immune System Framework / The Architecture of Secondary Stage Anti-Cooling-Coding-Maintenance (ACCM) Author: Sam Coole‌ Foreword This work is not a minor revision to existing immunology—it is a paradigm reset. For decades, the fi…
  datacite COOLE, SAM 2026 置信度 0.66
• Particle fluxes and gross erosion at limiters in JET low-confinement mode plasmas measured with visible cameras
  Nuclear fusion 65(4), 046021 - (2025). doi:10.1088/1741-4326/adbe8d
  datacite de la Cal, E., Solano, E. R., Balboa, I., Silburn, S. 等 2025 置信度 0.66 620
• 第一性原理:从自发对称破缺到万物理论-V4
  欢迎您加入SSB万物理论的推导和证明 1、目前已经严格证明本理论在宏观弱场稳态极限条件下和GR完全等价, 2、从朱山林方程还可以推导量子理论等,目前正在推导中,工作量巨大,期待您的加入。 长期以来,自发对称破缺(Spontaneous Symmetry Breaking, SSB)被局限于宇宙演化框架内,其普遍性与底层性被严重低估。目前Kurchan 等人已从数学上严格证明,自发对称破缺是热力学第二定律与时间箭头的起源[20],但仍将其视为宇宙内的动力学现象。本文突破 “宇宙内视角” 桎梏,通过哲学思辨与物理学理论…
  datacite 朱, 山林, 王, 倩 2026 置信度 0.66 自发对称破缺;多层次多维度;统一场方程;朱山林方程(ZSLE);第五种力;破缺本源梯度力;创世;第六种力;回归斥力;宇宙膨胀;回归;本源场;质量非内禀属性;所有力同源
• 第一性原理:从自发对称破缺到万物理论-V4
  欢迎您加入SSB万物理论的推导和证明 1、目前已经严格证明本理论在宏观弱场稳态极限条件下和GR完全等价, 2、从朱山林方程还可以推导量子理论等,目前正在推导中,工作量巨大,期待您的加入。 长期以来,自发对称破缺(Spontaneous Symmetry Breaking, SSB)被局限于宇宙演化框架内,其普遍性与底层性被严重低估。目前Kurchan 等人已从数学上严格证明,自发对称破缺是热力学第二定律与时间箭头的起源[20],但仍将其视为宇宙内的动力学现象。本文突破 “宇宙内视角” 桎梏,通过哲学思辨与物理学理论…
  datacite 朱, 山林, 王, 倩 2026 置信度 0.66 自发对称破缺;多层次多维度;统一场方程;朱山林方程(ZSLE);第五种力;破缺本源梯度力;创世;第六种力;回归斥力;宇宙膨胀;回归;本源场;质量非内禀属性;所有力同源
• Architecture of Crystalline Decompaction (MSO V'GER B4)
  MSO Protocol: Unified Field Theory -The Geometry of Suture and Residual Mass MSO Protocol: Unified Field Theory - The Geometry of Suture and Residual Mass Author: Fouconnier Yannick | Date: December 2025 | Protocol: ICN 1.0418 | © bb4you | Status: Architecture…
  datacite FOUCONNIER, Yannick 2026 置信度 0.66
• Architecture of Crystalline Decompaction (MSO V'GER B4)
  MSO Protocol: Unified Field Theory -The Geometry of Suture and Residual Mass MSO Protocol: Unified Field Theory - The Geometry of Suture and Residual Mass Author: Fouconnier Yannick | Date: December 2025 | Protocol: ICN 1.0418 | © bb4you | Status: Architecture…
  datacite FOUCONNIER, Yannick 2026 置信度 0.66
• Complex Frame Unified Theory (CFUT) / Topological Physics
  We introduce a new paradigm that unifies geometry, physics, and computation by promoting coordinate systems to primary algebraic objects (coord). This framework replaces traditional tensor calculus with intuitive operations like multiplication (*) for composit…
  datacite Pan, Guojun 2026 置信度 0.66 Coordinate SystemComputable Coordinate SystemsLie GroupsBerry ConnectionRiemann Curvature