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Abstract In this work, we utilize new coil objectives for stellarator optimization with autodifferentiation, including pointwise and net coil–coil forces and torques. We use these methods to perform the first large-scale optimization of planar dipole coil arra…
crossref
Alan A. Kaptanoglu, Alexander Wiedman, Jacob Halpern, Siena Hurwitz 等
2025-03-20T19:02:11Z
置信度 0.70
-
Abstract In plasma edge simulation of a nuclear fusion reactor, a coupled partial differential equation/kinetic description is required, which is usually solved with a coupled finite-volume/Monte Carlo method. Different procedures have been proposed to estimat…
crossref
Bert Mortier, Martine Baelmans, Giovanni Samaey
2025-08-22T22:50:00Z
置信度 0.70
-
Abstract This paper presents a first detailed gyrokinetic analysis with the goal of understanding the dominant turbulent transport mechanisms and identifying the micro-instabilities present in small-aspect-ratio plasmas in the PI3 device, developed as magnetiz…
crossref
N. Kumar, G. Avdeeva, J. Candy, M. Reynolds 等
2025-07-15T22:49:03Z
置信度 0.70
-
Abstract As the magnetic confinement fusion community prepares for the next generation of fusion devices and burning plasmas, there is still a question of whether fast ions (FIs) will drive MHD instabilities, causing significant redistribution or even loss of …
crossref
R.A. Tinguely, J. Gonzalez-Martin, Y. Todo
2025-01-28T22:51:37Z
置信度 0.70
-
crossref
Pavel O. Savelev, Andrei I. Shumeiko
2025-09-08T19:49:28Z
置信度 0.70
-
crossref
Matteo Lo Verso, Stefano Riva, Carolina Introini, Eric Cervi 等
2025-04-26T11:34:17Z
置信度 0.70
-
Abstract Determining stress and strain in a component of a fusion power plant involves defining boundary conditions for the mechanical equilibrium equations, which implies the availability of a full reactor model for defining those conditions. To address this …
crossref
W.M.E. Ellis, L. Reali, A. Davis, H.M. Brooks 等
2025-02-10T22:50:02Z
置信度 0.70
-
Abstract Runaway electrons (REs) during the Current Quench can significantly impact the operational limits and component lifetime of future high-performance tokamaks such as ITER. Localized, uncontrolled REs deposition can result in serious damage to first wal…
crossref
Yuxiang Sun, Bo Li, Feng Wang, Di Hu 等
2025-07-24T22:48:58Z
置信度 0.70
-
Abstract The fast deconfinement of a vertically unstable runaway beam is investigated using a 0-D model which includes self-consistently the vertical plasma motion and the generation of runaway electrons Kiramov and Breizman (2017 Physics of Plasmas 24 100702)…
crossref
J.R. Martín-Solís, J.A. Mier, F.J. Artola, A. Loarte
2025-05-21T22:48:17Z
置信度 0.70
-
Abstract We present NeuralBranch, an interpretable neural network framework. In this work, we use it specifically to predict the pedestal from key engineering parameters in tokamak fusion experiments. The main goal is to uncover intricate relationships that tr…
crossref
A. Gillgren, A. Ludvig-Osipov, D. Yadykin, P. Strand
2025-04-11T22:49:41Z
置信度 0.70
-
crossref
Sangaralingam Ramesh
2025-03-23T01:26:30Z
置信度 0.70
-
Abstract The maximum likelihood expectation maximization (MLEM) algorithm has been introduced as a robust solution to address the challenges associated with the high condition number of response matrix encountered in the beta ray induced x-ray spectra (BIXS) t…
crossref
Minxiang Shu, Zhilin Chen, Yang Yang, Po Huang 等
2025-05-20T22:49:12Z
置信度 0.70
-
Abstract Linear growth of internal kink mode is investigated using a kinetic-MHD hybrid simulation model under realistic tokamak conditions. By comparing purely fluid (single-fluid MHD) simulations with kinetic thermal ion simulations using various coupling sc…
crossref
Jiangyue Han, Yasushi Todo, Hao Wang, Masahiko Sato 等
2025-07-21T22:49:01Z
置信度 0.70
-
Abstract The Imaging Neutral Particle Analyzer (INPA) at DIII-D is a diagnostic system used to accurately resolve the energy and spatial distributions of fast ions in fusion plasmas. A novel artificial intelligence (AI) technique named INPA-net is based on Res…
crossref
Alvin Garcia, Sydney Liu, Xiaodi Du, Max Curie 等
2025-03-26T22:49:49Z
置信度 0.70
-
crossref
2025-04-11T01:35:51Z
置信度 0.70
-
This research note evaluates the validity and temporal dynamics of the transition from chemical exothermic reaction paths to nuclear fusion in condensed matter systems. Evidence suggests that intense mechanical compression of fuel mixtures can trigger internal…
crossref
Ahmed Hala
2026-03-12T12:42:08Z
置信度 0.70
-
Abstract Using a single toroidal array of coils to reduce the m , n = 2 , 1 resonant error field (EF) produced by the misalignment of the axisymmetric coils in SPARC can result in the enhancement of the local divertor heat fluxes. Managing high divertor heat f…
crossref
S. Munaretto, A. Kleiner, R.M. Churchill, D. Corona 等
2025-02-24T22:47:51Z
置信度 0.70
-
crossref
2026-04-26T07:15:33Z
置信度 0.70
-
Abstract A simple model of the ramp-up and ramp-down of the toroidal current in a tokamak plasma is developed. Faraday’s law of electric induction is found to limit how rapidly the current can be safety ramped up or down. It is estimated that the minimum compl…
crossref
Richard Fitzpatrick
2025-10-14T22:49:02Z
置信度 0.70
-
Abstract To accelerate the development of a radio frequency negative ion source (RF-NIS), a fusion neural network model has been developed to simulate and predict the performance of RF-NIS under set working parameters. The model leverages the setting parameter…
crossref
Yu Gu, Chundong Hu, Yang Li, Yuwen Yang 等
2025-07-31T22:48:31Z
置信度 0.70
-
Abstract We present a tearing stable, stationary and reproducible operating solution for DIII-D plasmas characterized by the ITER baseline scenario normalized parameter set and shape. In these plasmas low differential rotation ( Δ f 1 , 2 ) between the core an…
crossref
L. Bardóczi, A. Dudkovskaia, N.C. Logan, N.J. Richner 等
2024-12-13T22:49:01Z
置信度 0.70
-
Abstract The TJ toroidal tearing mode code is used to make realistic predictions of the electron cyclotron emission (ECE) signals generated by neoclassical tearing modes (NTMs) in an ITER-like tokamak plasma equilibrium. In the so-called ‘outer region’, which …
crossref
Richard Fitzpatrick
2025-11-13T22:48:31Z
置信度 0.70
-
Abstract Coupling a high-performance burning plasma core to a detached boundary solution is critical for realizing magnetic confinement fusion power. Predictive simulations of the edge and scrape-off layer are therefore essential and must self-consistently acc…
crossref
K. Eder, W. Zholobenko, A. Stegmeir, M. Bernert 等
2025-08-07T22:49:28Z
置信度 0.70
-
crossref
M.A. Miller, J.W. Hughes, S. Mordijck, M. Wigram 等
2024-12-27T16:58:53Z
置信度 0.70
-
Abstract Multi-modal, active 3D MHD spectroscopy is applied in high-performance advanced tokamak scenarios to study their stability time evolution, revealing an intriguing dependence on both q min and β N . A tailored applied 3D field provides a 3D plasma resp…
crossref
S.M. Yang, S. Munaretto, T. Liu, Q. Hu 等
2025-08-01T22:48:47Z
置信度 0.70
-
On December 20, 1951, Experimental Breeder Reactor No. 1 (EBR-I), located at Argonne National Laboratory, produced enough electricity to power four light bulbs. From these modest beginnings, the civilian application of nuclear energy became a reality. The firs…
crossref
Amir Zacarias Mesquita
2025-05-21T18:41:37Z
置信度 0.70
-
Abstract The dynamical mechanism by which zonal flows (ZFs) regulate turbulent transport is experimentally investigated on the basis of the density-potential coupling and energy transfer functions. It is shown that the occurrence of intermittent ZF events dete…
crossref
R. Sarkis, G.E.M. Tovar, M. Ramisch
2025-11-27T22:49:58Z
置信度 0.70
-
crossref
Ayan Kumar Makar
2025-09-16T13:07:36Z
置信度 0.70
-
Abstract A computational fluid dynamics model of ELM-induced tungsten melt flow across a gap between misaligned plasma-facing components is validated against data from dedicated leading-edge exposures in the ASDEX Upgrade tokamak. The macroscopic behavior of t…
crossref
L. Vignitchouk, S. Ratynskaia
2025-03-25T22:58:41Z
置信度 0.70
-
Abstract In this paper, we use hybrid simulation to elucidate the plasma heating mechanism due to waves excited in Field-Reversed Configuration (FRC) plasma. The plasma parameters are a separatrix radius of 0.16 m and a separatrix length of 1.16 m ( x -point p…
crossref
Takahiro Urano, Toshiki Takahashi, Naoki Mizuguchi, Tomohiko Asai 等
2025-02-05T22:51:21Z
置信度 0.70
-
crossref
Mauricio Comas-Garcia
2025-10-16T14:31:50Z
置信度 0.70
-
Abstract Through SOLPS-ITER simulations, we have investigated the ability of seeded argon and neon impurities to effectively control divertor power loading in a power-plant-class spherical tokamak geometry. We consider a connected double null equilibrium, with…
crossref
S.L. Newton, R.T. Osawa, S.S. Henderson, D.J. Moulton 等
2025-08-05T22:48:42Z
置信度 0.70
-
Laser-induced nuclear fusion offers the tantalizing prospect of a clean, virtually limitless energy source. Traditional inertial confinement fusion (ICF) approaches struggle with challenges in laser efficiency, beam uniformity, and target design. The present r…
crossref
Ayan Kumar Makar
2025-09-16T13:07:36Z
置信度 0.70
-
crossref
A. Houben, E. Warkentin, M. Rasiński, T. Dittmar 等
2025-11-20T03:57:57Z
置信度 0.70
-
Abstract The timely and accurate quench detection system is an important guarantee for the safe operation of fusion devices. For the superconducting magnets with rapidly changing current in the fusion device, the core challenge is to compensate for the complex…
crossref
Qing Yan, Yanlan Hu
2025-01-31T22:49:41Z
置信度 0.70
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While a variety of laboratory-based fusion schemes have been studied for decades, the only fusion scheme yet to demonstrate fusion ignition and significant energy gain has been X-ray-driven inertially confined fusion. Ignition was demonstrated to occur at the …
crossref
Omar A. Hurricane
2025-06-06T14:01:48Z
置信度 0.70
-
crossref
Sharon Robinson, K. Fessler, Bradley Patton
2025-11-17T13:40:32Z
置信度 0.70
-
crossref
Michael Loughlin
2026-05-22T23:08:47Z
置信度 0.70
-
crossref
2026-04-26T07:15:33Z
置信度 0.70
-
crossref
Joseph Sorroche
2026-05-09T08:18:41Z
置信度 0.70
-
Diabetes mellitus (DM) disrupts cellular homeostasis and is characterized by mitochondrial structural and functional impairments similar to those found in other metabolic disorders. Mitochondrial dysfunction (MD) leads to the excessive production of reactive o…
pubmed
Manojlovic M, Zafirovic S, Tomic Naglic D, Stokic E 等
2025 Oct 23
置信度 0.82
-
DNA polymerase θ (Polθ) is a polymerase-helicase fusion protein that is synthetically lethal with homologous recombination (HR) factors, such as BRCA1/2, and confers resistance to PARP inhibitors (PARPi) and other genotoxic cancer therapies. Previo…
pubmed
Chandramouly G, Fried W, Gordon J, Ralph D 等
2025 Nov 13
置信度 0.82
-
MED15-TFE3 rearranged renal cell carcinoma (MED15-TFE3 rRCC) is a rare subtype of TFE3-rearranged renal cell carcinoma (TFE3 rRCC). To date, only 47 cases of MED15-TFE3 rRCC (including 2 cases from our institution) have been reported worldwide.
pubmed
Deng Z, Xu Y, Duan E, Zhang X 等
2025 Oct 21
置信度 0.82
-
Clear cell renal cell carcinoma is the predominant pathological subtype of renal cell carcinoma, characterized by abnormal lipid metabolism. This study aimed to investigate the role of nuclear receptor co-activator 7 (NCOA7)-mediated autophagy in lipid metabol…
pubmed
Wang J, Luo H, He Q, Shao H 等
2025 Oct 21
置信度 0.82
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Human trophoblast stem (TS) cells differentiate into syncytiotrophoblasts (STBs) through cell-cell fusion, forming the outermost layer of the placental villus to enable nutrient and gas exchange between the mother and fetus. GCM1 (glial cells missing 1) is a p…
pubmed
Wang LJ, Pao YH, Tseng YJ, Ng PS 等
2025 Oct 31
置信度 0.82
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In the field of medical imaging, gamma cameras, single photon emission computed tomography (SPECT), and SPECT/CT are critical diagnostic tools. Quality control is essential for these devices because equipment malfunctions may lead to degraded image quality, th…
pubmed
Zhang S, Han Y, Wang G, Liu N 等
2025 Sep 30
置信度 0.82
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Mammalian spermatogenesis is a highly dynamic process involving male germ cell self-renewal and terminal differentiation into progenitor cells that produce testicular sperm in coordination with testicular somatic support cells. Multinuclear giant cells identif…
pubmed
Simerly C, Hartnett C, Zyhowski A, Robertson E 等
2025 Oct 17
置信度 0.82
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Metabolic dysfunction-associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6-methyladenosine (m 6 A)-modified circular RNAs (circRNAs) play key roles in tumor mali…
pubmed
Fu J, Wei Y, Yang Y, Yang X 等
2025 Nov
置信度 0.82
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Intensive care unit-acquired weakness (ICU-AW) represents a prevalent and debilitating complication among critically ill patients, distinguished by profound skeletal muscle atrophy and functional deterioration. Leptin, a hormone predominantly released by adipo…
pubmed
Li M, Yang L, Li T, Miao Y 等
2025 Oct 16
置信度 0.82
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This case report describes a 71-year-old male patient in whom a solitary fibrous tumor (SFT) of the pancreatic tail was incidentally discovered during staging of chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL). The patient also had a histor…
pubmed
Hrudka J, Eis V, Matěj R
2025
置信度 0.82
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Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young people. Despite the advances in multimodality treatment over recent decades through successive prospective clinical trials, improved rates of survival for patients are mainly l…
pubmed
Wasti AT, Bisogno G, Hladun R, Defachelles AS 等
2025 Sep 23
置信度 0.82
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During T cell activation, mitochondrial biogenesis and cellular metabolism are altered to meet the elevated energy demands of protein synthesis, rapid proliferation, and effector T cell function. The mechanisms coupling mitochondrial dynamics to T cell status …
pubmed
Galloway A, Knop K, Gomez-Moreira C, Xavier V 等
2025 Oct 28
置信度 0.82
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Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. In particular, patients with chronic myeloid leukemia (CML) often require lifelong therapy with ABL1 tyrosine kinase inhibitors (TKIs), partly due to a …
pubmed
Turner KA, Chen M, Rothe K, Forrest DL 等
2025 Oct 9
置信度 0.82
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By means of path integral Monte Carlo simulations based on a coarse-grained model parameterized by first-principles calculations, we reproduce the large isotope effect observed in H-bonded KH2PO4 (KDP) and deuterated DKDP, showing that the dramatic shift in th…
pubmed
Torresi F, Lasave J, Tosatti E, Kohanoff J 等
2025 Oct 21
置信度 0.82
-
The global incidence of thyroid cancer has significantly increased, while traditional pathological diagnosis remains time-consuming and expert-dependent. This study develops an auxiliary diagnostic tool designed to reduce the workload of pathologists and impro…
pubmed
Li X, Liu G, Sun M, Wang L 等
2025 Oct 14
置信度 0.82
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This study investigates the surface modification of Fluorinated Polytetrafluoroethylene PTFE and Non-Fluorinated polyethylene PE, two widely used polymers with inherent hydrophobicity and poor adhesion, using atmospheric air plasma generated by Surface Dielect…
pubmed
Jamali S, Kargarian A
2025 Oct 14
置信度 0.82
-
The fusion process of myoblasts constitutes a critical phase in skeletal muscle myogenesis. The recently identified transmembrane protein Myomaker, which is muscle-specific, plays an indispensable role in myoblast fusion. However, the regulatory mechanisms of …
pubmed
Weng S, Hu M, Ji W, Zeng Y 等
2026 Jan
置信度 0.82
-
Adoptive cell therapy (ACT) with tumour-infiltrating lymphocytes (TIL) is an effective personalised immunotherapy for patients with advanced pretreated melanoma. For TIL-ACT, tumour-specific T cells are expanded from excised tumour samples and stimulated in ce…
pubmed
Canini E, Pacchin L, Blackham AK, Lorscheider J 等
2025 Aug 21
置信度 0.82
-
Ewing sarcoma is a highly aggressive tumor arising in bones and soft tissues, driven by the fusion oncoprotein EWSR1::FLI1. This aberrant transcription factor binds to GGAA microsatellites, causing epigenetic reprogramming through the formation of active neoen…
pubmed
Figuerola-Bou E, Ríos-Astorch C, Blanco E, Sánchez-Jiménez M 等
2025 Nov 14
置信度 0.82
-
The thinprep cytologic test is widely used for cervical cancer diagnosis, with results reliant on cytotechnicians screening specific cell categories on slides, lacking robustness. This paper introduces a two-stage quantitative detection framework for whole sli…
pubmed
Zhang C, Jia D, Wang Z
2025 Oct 13
置信度 0.82
-
Colorectal cancer (CRC) onset is closely linked to dysregulated Notch signaling, particularly involving receptors like Notch1 and Notch3, and ligands such as Jagged1 (Jag1), which are overexpressed in aggressive subtypes. To address the need for a quantitative…
pubmed
Punzo A, Silla A, Pannuti A, Gozzi G 等
2025 Sep-Oct
置信度 0.82
-
Spindle cell rhabdomyosarcomas (SCRMS), recognized by the 2020 World Health Organization Classification of Tumors of Soft Tissue and Bone as a distinct entity, comprise a family of malignant skeletal muscle tumors sharing spindle cell morphology. To date, memb…
pubmed
Dehner CA, Ameline B, Amary F, Gross JM 等
2025 Dec
置信度 0.82
-
Mitochondrial diseases are a group of serious inherited multisystem disorders caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA and still have faced a significant challenge to therapy due to their complicated genotype-phenotype relationships and …
pubmed
Pu Z, Wang P, Wang M, Chen Y 等
2025 Oct 10
置信度 0.82
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Objective: To investigate the clinicopathological features, immunophenotype and molecule characteristics of EWSR1::CREM fusion malignant epithelioid neoplasm in soft tissue. Methods: The clinical and pathological data of 2 cases of EWSR1::CREM fusion malignant…
pubmed
Dong RF, Ding Y, Li ZQ, Li L 等
2025 Oct 8
置信度 0.82
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Objective: To analyze the cytological, histological, immunohistochemical, and molecular pathological features of hyalinizing trabecular tumor (HTT). Methods: Clinical and pathological data of the HTT cases diagnosed at Shanghai Sixth People's Hospital affiliat…
pubmed
Hu DJ, Luo YL, Zhao YW, Xie YX 等
2025 Oct 8
置信度 0.82
-
NMR-guided investigation of Nigella glandulifera Freyn et Sint seeds led to the isolation and characterization of 11 previously undescribed alkaloids, designated nigelladine D-N (1-11). These include three skeletons: (+)/(-)-nigelladine D (1a/1b), and nigellad…
pubmed
Tudi T, Rouzimaimaiti R, Zang D, Zhao J 等
2026 Feb
置信度 0.82
-
pubmed
Gao X, Xu Y
2025 Dec
置信度 0.82
-
Osteosarcoma is a highly malignant bone tumor that occurs primarily in children and adolescents. Ki67 protein expression level (detected through immunohistochemistry) is an important indicator for assessing tumor proliferative activity. This study aims to deve…
pubmed
Wang Q, Ma Q, Li X, Ben S 等
2026 Jan
置信度 0.82
-
SMARCA4 -deficient non-small cell lung cancers are usually of poor prognosis and associated with smoking-related mutations. Here, we report the case of a SMARCA4 -deficient non-small cell lung cancer (NSCLC) occurring in a non-smoker female and harboring ALK f…
pubmed
Désage AL, Pointel S, Ezingeard E, Bayle-Bleuez S 等
2026 Jan 1
置信度 0.82
-
W and W-based high-entropy alloys are promising candidates for plasma-facing materials in fusion reactors. While irradiation studies on W have revealed a tendency for helium (He) bubble formation and radiation-induced defects, investigations of WTaCrV high-ent…
pubmed
Esfandiarpour A, Kalita D, Kozioł Z, Alava M
2025 Oct 5
置信度 0.82
-
Epstein‒Barr virus (EBV) is a ubiquitous gammaherpesvirus linked to a broad spectrum of malignancies and autoimmune diseases with no approved therapeutic drugs or vaccines. EBV infection relies on the viral glycoproteins gB and gHgL, which, together, fu…
pubmed
Sun C, Xie C, Fang XY, Hong DC 等
2026 Feb
置信度 0.82
-
We report a rare TFE3-rearranged perivascular epithelioid cell tumor (PEComa) of the parasternal chest wall diagnosed preoperatively by fine-needle aspiration (FNA) cytology. The smears and cell block showed epithelioid cells with clear to granular cytoplasm a…
pubmed
Dev S, Miller M, Hu T, McGrath C 等
2026 Jan
置信度 0.82
-
Epithermal neutron resonance spectroscopy is a key nondestructive approach for discerning material properties. However, the existing spallation and accelerator-based photonuclear neutron sources employed in this spectroscopy are huge and immobile, restricting …
pubmed
Feng J, Ren J, Xu H, Zhu M 等
2025 Oct 7
置信度 0.82
-
Rationale: The mode of action of [ 177 Lu]Lu-PSMA-617 (LuPSMA) therapy is not fully understood and a relevant fraction of patients show treatment failure. Therefore, this study aimed to investigate the prognostic significance of immune suppression in the tumor…
pubmed
Handke A, Lopes L, Kesch C, Darr C 等
2025
置信度 0.82
-
Drugs that reprogram the cellular ubiquitin-proteasome system for removal of disease-causing proteins hold great promise as a new type of pharmacology. Small ubiquitin-related modifier (SUMO)-targeted ubiquitin ligases (StUbLs) are E3 ubiquitin ligases that me…
pubmed
Gotthardt G, Keiten-Schmitz J, Müller S
2025 Nov
置信度 0.82
-
Countries across Africa are experiencing the dual challenge of rising cancer burden and severe health-care workforce shortages, which threaten to overwhelm its already strained health systems. Simultaneously, advancements in digital health technologies, includ…
pubmed
Dako F, Moraes FY, Doo F, Abed M 等
2025 Oct
置信度 0.82
-
With the first series of PRRX1 -rearranged tumors published in 2019, the spectrum of these so-called fibroblastic tumors has been expanded. Since then, several smaller case series have been published; however, our understanding of them continues to be quite li…
pubmed
Dehner CA, Torres-Mora J, Thangaiah JJ, Oliveira A 等
2026 Jan 1
置信度 0.82
-
Astatine ( 211 At) is an alpha-emitting nuclide with a 7.2-hour half-life that can be produced using a 30-MeV cyclotron. In recent years, the number of production sites worldwide has been increasing, attracting growing attention to 211 At. We have developed a …
pubmed
Watabe T, Naka S, Shirakami Y, Kaneda K 等
2025 Sep 30
置信度 0.82
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Herpesvirus egress begins with primary envelopment of newly assembled capsids at the inner nuclear membrane (INM). Primary envelopment has been observed at the peripheral INM as well as nuclear infoldings. Nuclear infoldings from invaginations of the INM are T…
pubmed
Wilson A, Ridgway ND, McCormick C
2025 Oct 23
置信度 0.82
-
The energy spectra of primary deuterium-tritium (DT) neutrons provide essential information about the implosion performance in inertial confinement fusion (ICF) experiments. Recoil proton track imaging is a recently developed technique for measuring neutron en…
pubmed
Sang Y, Zhang Q, Liu J, Guo H 等
2025 Sep 1
置信度 0.82
-
This study aimed to elucidate the spectrum of clinical manifestations, cytomorphology, immunophenotype, and the molecular genetic features of lymphoblastic lymphoma/acute lymphoblastic leukemia (LBL/ALL) in the context of serous effusions (SE).
pubmed
Cui W, Ding X, Liu J, Hu P 等
2026
置信度 0.82
-
To develop and evaluate deep learning (DL) models for detecting multiple retinal diseases using bimodal imaging of color fundus photography (CFP) and optical coherence tomography (OCT), assessing diagnostic performance and generalizability.
pubmed
Gu X, Zhou Y, Zhao J, Zhang H 等
2025
置信度 0.82
-
To construct a pathomics-based machine learning model to enhance the diagnostic efficacy of LungPro navigational bronchoscopy for peripheral pulmonary lesions and to optimize the management strategy for LungPro-diagnosed negative lesions.
pubmed
Ying F, Bao Y, Ma X, Tan Y 等
2025 Sep 26
置信度 0.82
-
To address the issue of decreased positioning accuracy caused by interference or blockage of GNSS signals in vehicle navigation systems, this paper proposes a GNSS/MEMS IMU array fusion localization method based on an improved grey prediction model. First, a m…
pubmed
Chen Y, Liu J, Qin W, Li C
2025 Sep 11
置信度 0.82
-
Cellular senescence is a major barrier to the therapeutic application of human mesenchymal stem cells (hMSCs), as it compromises their proliferative capacity, differentiation potential, and regenerative efficacy. In this study, we investigated whether FN9-10EL…
pubmed
Jang SH, Jang JH
2025 Sep 21
置信度 0.82
-
CRISPR interference (CRISPRi), the fusion of transcriptional repressor domains to nuclease-inactive Cas9, is a powerful genetic tool enabling site-specific suppression of gene expression. However, its performance remains inconsistent across cell lines, gene ta…
pubmed
Kristof A, Karunakaran K, Ferry Y, Mizote P 等
2025 Dec
置信度 0.82
-
The clinical application of CRISPR-Cas9 remains limited by delivery challenges, particularly for oral administration. Lysine-specific demethylase 1 ( Lsd1 ) plays a key role in colonic inflammation and tumorigenesis. Here, we developed an oral genome-editing p…
pubmed
Gao Q, Gao Y, Cao Y, Xu H 等
2025 Sep 26
置信度 0.82
-
Nucleoporin 214 (NUP214) is a component of the nucleopore molecular complex, but in addition to this role in nucleocytoplasmic transport it is also involved in the regulation of gene transcription/translation, intracellular signaling, cell cycle progression an…
pubmed
Bruserud Ø, Reikvam H
2025 Sep 18
置信度 0.82
-
NUT carcinoma (NC) is a rare epithelial malignancy caused by a rearrangement of the nuclear protein in testis gene (NUTM1), with fewer than 200 cases reported worldwide to date. The majority of cases have occurred in young patients (ie, ≤25 years of age…
pubmed
Stock A, Fan C, Lewis S, Schwartz M 等
2025 Nov 19
置信度 0.82
-
The low computation efficiency impeded the broad application of Monte Carlo (MC) simulation to particle therapy. The existing deep learning (DL) methods for fast dose calculation lacked physics-based interpretability, hence, may introduce additional risks, esp…
pubmed
Zhang J, Lai Y, Feng H, Luo X 等
2025 Oct
置信度 0.82
-
Alzheimer's disease (AD) is characterized by accumulation of amyloid-β (Aβ) plaques, tau neurofibrillary Tangles and synaptic dysfunction. The aim of this study was to map the distributions of synaptic vesicle protein 2A (SV2A) and other synaptic p…
pubmed
Nussbaumer J, Barve A, Zufferey V, Espourteille J 等
2025 Sep 24
置信度 0.82
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Claudin 18.2 (CLDN18.2) is predominantly expressed in the gastric mucosa and becomes exposed and accessible during malignant transformation. Its highly restricted expression pattern and function in gastric cancer (GC) make CLDN18.2 a promising target for the t…
pubmed
Wang J, Lou K, Chen L, Zhang Y 等
2026 Feb 1
置信度 0.82
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Objective . Integrated positron emission tomography (PET)/computed tomography (CT) imaging plays a vital role in tumor diagnosis by offering both anatomical and functional information. However, the high cost, limited accessibility of PET imaging and concerns a…
pubmed
Wang H, Zou W, Wang J, Li J 等
2025 Oct 9
置信度 0.82
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Protein glycosylation is a widely occurring post-translational modification catalyzed by glycosyltransferases and is involved in various biological functions. O- N-acetylgalactosamine (O-GalNAc) modification is catalyzed by the N-acetylgalactosaminyltransferas…
pubmed
Xu B, Zhang M, Yu Y, Yang M 等
2025 Dec
置信度 0.82
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Aloperine (ALO), a quinolizidine-type alkaloid isolated from a natural Chinese herb, exhibits anticancer activity in several malignancies, but its efficacy and mechanisms in gallbladder cancer (GBC) remain undefined.
pubmed
Chang Y, Lin J, Yang B, Shen Y 等
2025 Dec 3
置信度 0.82
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The intestine is an important organ in radiotherapy of the abdominal region, and radiation-induced intestinal injury (RIII) is an undesirable biological response to radiotherapy. Radiotherapy is known to induce oxidative stress associated with the generation o…
pubmed
Adachi K, Hyodo F, Elhelaly AE, Ichihashi K 等
2025 Sep 24
置信度 0.82
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Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of the XPO1 transportat…
pubmed
Benetatos L, Hatzimichael E, Kapsali E
2025 Sep 24
置信度 0.82
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Mesenchymal tumors of the gastrointestinal (GI) tract include a range of entities such as gastrointestinal stromal tumor (GIST), schwannoma, and leiomyoma; however, the genetic background of GI leiomyomas has not been elucidated. Herein, we report a case of re…
pubmed
Kunieda J, Yamashita K, Dobashi A, Togashi Y 等
2026 Jun
置信度 0.82
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The development of radiochemical measurement techniques as a diagnostic for fusion experiments at the National Ignition Facility enables a new method for assessing fuel-ablator mix and the impact of this mix on capsule performance. Diagnosing capsule mix in in…
pubmed
Kmak KN, Despotopulos JD, Huynh TL, Sammis BN 等
2025
置信度 0.82
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Silica optical fiber sensors offer a fast, distributed measurement solution in various cryogenic and radiation environments, such as magnets for fusion power. Under these conditions, light-absorbing point defects limit lifetime via radiation-induced attenuatio…
pubmed
Legoupil AYM, Kirby R, Lamere E, Christianson R 等
2025 Sep 1
置信度 0.82