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Single-cell RNA sequencing (scRNA-seq) has emerged as a critical tool in oncology research, revealing key aspects of immune infiltration, tumor heterogeneity, and the tumor microenvironment. However, most scRNA-seq experiments capture only a portion of the 5'-…
pubmed
Byrne A, Felton C, Stephenson W
2026
置信度 0.82
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Ventricular fibrillation (VF) is a malignant tachyarrhythmia underlying cardiac arrest, yet the mechanisms maintaining VF remain incompletely understood. Ethical constraints and technical limitations have largely precluded systematic investigation of sustained…
pubmed
Tonko JB, Kappadan V, El-Medany A, Aggour H 等
2026
置信度 0.82
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The clinical management of neurological disorders remains a major challenge worldwide, constrained by fundamental limitations in both diagnosis and therapy. Electroencephalography (EEG), the cornerstone of neurological assessment, is limited by low spatial res…
pubmed
Wang NN, Cao F, Xu D
2026
置信度 0.82
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A predictive coding (PC) framework assumes that the visual cortex generates and tests hypotheses about the likely causes of retinal stimulation. In doing so, it requires computation of the error between the predicted model and the sensory data. By contrast, a …
pubmed
Domijan D
2026
置信度 0.82
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Coronary atherosclerotic plaque vulnerability is determined not only by luminal stenosis but also by plaque composition, calcification pattern, inflammatory activity, and local microenvironmental changes. Conventional coronary computed tomography angiography (…
pubmed
Liu Y, Peng Y, Wu H, Li Y
2026
置信度 0.82
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Non-small cell lung cancer (NSCLC) remains one of the leading causes of global cancer mortality despite advances in immunotherapy. While immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have transformed clinical outcomes for selected patients,…
pubmed
Abuhassan Q, Al-Ameer HJ, Balogh Z, Rekha MM 等
2026
置信度 0.82
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Sentinel lymph node (SLN) mapping is essential for cancer staging and image-guided surgical management, but conventional blue dyes, radiocolloids, and fluorescence tracers remain limited by spatial resolution, penetration depth, and single-modality readouts. G…
pubmed
Lee SB
2026 Jul
置信度 0.82
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Whether consciousness serves a biological and psychological function is a topic of intense interest. We reexamine this issue by first focussing on an objection against consciousness having a function raised amongst others by Jaegwon Kim. His argument targets a…
pubmed
Pennartz CMA, Engeser M
2026 Aug
置信度 0.82
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Single-cell genetic perturbation screens are increasingly used to study gene function at single-cell resolution. However, their analysis remains difficult because available computational methods differ in assumptions, input requirements, and output definitions…
pubmed
Zhang Y, Huang J, Li Y, Liu T 等
2026 Jun 13
置信度 0.82
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Three-dimensional (3D) bioprinting has rapidly evolved into a controlling platform for the fabrication of patient-specific biomedical implants, with growing importance in advanced drug delivery systems. Beyond structural tissue engineering, bioprinted construc…
pubmed
Phan TNL, Truong TT, Vo TH, Pham VH 等
2026 May 22
置信度 0.82
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Introduction : Schizophrenia is characterised by distributed abnormalities in electrophysiological dynamics and large-scale brain networks, yet unimodal EEG or MRI alone cannot fully explain how fast neural computations relate to spatially organised circuit dy…
pubmed
Chmiel J, Kopańska M
2026 Jun 2
置信度 0.82
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Hemodynamic failure remains a major determinant of mortality in critical illness, yet its detection is often delayed because conventional monitoring relies predominantly on Eulerian measurements that quantify pressure and flow magnitude without resolving the s…
pubmed
Chalkias A, Katsifa K, Amanetopoulou S, Karapiperis G 等
2026 Jun 1
置信度 0.82
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Drought stress is the most pervasive abiotic constraint on global crop productivity, with projected intensification under climate change threatening the yields of staple crops including wheat, rice, maize, and legumes. Conventional breeding approaches have del…
pubmed
Ali B, Khan Z, Imin N, Janda T 等
2026 Jun 1
置信度 0.82
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Glioblastoma multiforme (GBM) remains a devastating disease with a poor prognosis. GBM progression generates mechanical forces that compromise blood vessels' functionality, impair perfusion, and create hypoxic regions, which in turn reduce radiosensitivity. Wh…
pubmed
Harkos C, Dimou K, Koutsi M, Roussakis Y 等
2026 Jun 11
置信度 0.82
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Accurate International Society of Urological Pathology (ISUP)-grade classification of renal cell carcinoma (RCC) is challenging due to subtle histopathological variations and the limitations of manual review. Existing deep learning models often rely on complex…
pubmed
Alwateer M
2026 Jun 11
置信度 0.82
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Environmental proteomics has emerged as a powerful approach for elucidating the molecular mechanisms underlying pollutant-induced biological effects. Although this field has developed rapidly, the systematic review of recent proteomics applications in environm…
pubmed
Wei C, Zeng B, Zhou X, Qing B 等
2026 Jun 11
置信度 0.82
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Understanding how tumor cells navigate crowded spatial environments to drive progression and how to deter them is challenging. Intracellularly, dynamic protein ensembles link genotype to phenotype. Dysregulation of these ensembles-driven by overexpression and …
pubmed
Nussinov R, Jang H
2026 Aug
置信度 0.82
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Multimodal single-cell profiling technologies generate heterogeneous and high-dimensional molecular measurements across multiple cellular modalities. Although several reviews have discussed multimodal single-cell integration broadly, technical noise modelling …
pubmed
Mallampalli SS, Madan A, Jain CK
2026 Oct
置信度 0.82
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Traditional radiomic studies build texture matrices using single-voxel increments. However, useful information may emerge when radiomic features are instead evaluated across multiple spatial scales. Moreover, basing these scales on physical units may produce r…
pubmed
Lefcourt S, Kim A, Huang P, Weiss C 等
2026 Jun 11
置信度 0.82
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Object-location memory (OLM) is the ability to encode and retrieve spatial relationships between objects by using egocentric or allocentric reference frames. Critically, OLM is modulated by emotional memory systems that engage amygdala-hippocampal and arousal-…
pubmed
Solares L, García-Navarra S, Mendez M, Mendez-Lopez M
2026 Jun 10
置信度 0.82
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Cardiac computed tomography (cCT) has emerged as a valuable imaging modality in veterinary cardiology and can be used to visualize and understand diseases that affect the mitral and tricuspid valves of dogs. While echocardiography remains the primary diagnosti…
pubmed
Scansen BA
2026 May 20
置信度 0.82
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The heart is a structurally complex organ where function is intimately tied to the precise spatial organization of diverse cell types. While single-cell RNA sequencing (scRNA-seq) has revolutionized cardiovascular research by providing a high-resolution "parts…
pubmed
Hanna A
2026
置信度 0.82
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Autoimmune diseases are systemic disorders in which barrier-site immune activation, especially in the gut, can reshape inflammatory programs in distant organs. This review advances a metabolite-centered, cross-organ framework for understanding how gut microbia…
pubmed
Rao X, Zou L, Cai X, Yao Y 等
2026
置信度 0.82
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Noncoding RNAs (ncRNAs) are increasingly recognized as important therapeutic targets across human diseases, driving advances in RNA-targeting modalities. However, successful therapeutic engagement depends on key biochemical properties of the target ncRNA, incl…
pubmed
Chan JW, Daly CWP, Vargas-Velazquez AM, Chow PKH 等
2026 Jul
置信度 0.82
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Accurate cross-sectional imaging is essential for diagnosis, procedural planning, and postintervention surveillance in patients with peripheral artery disease (PAD). Conventional computed tomography angiography (CTA) is limited by calcium blooming, beam harden…
pubmed
Zivkovic M, Raskin D, Ghibes P, Beck E 等
2026 Aug
置信度 0.82
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The immune system operates within organized tissue landscapes, where spatial relationships between cells shape the nature and outcome of immune responses. Over the past decade, protein imaging-based spatial technologies have transformed how immune responses ar…
pubmed
Cárdenas-Piedra L, Samuel SG, Mungenast F, Yasothkumar D 等
2026 Jun
置信度 0.82
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Gastric cancer (GC) remains a formidable global health challenge, characterized by pronounced molecular heterogeneity, late-stage diagnosis, and limited durable responses to existing therapies. This review synthesizes recent advances in GC research through an …
pubmed
Yu R, Zhang M, Meng Y, Zhu C 等
2026 Jun
置信度 0.82
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High-dose-rate brachytherapy (HDR-BT) is a critical modality in the treatment of cervical cancer, requiring accurate and efficient treatment planning. Unlike external beam radiation therapy, HDR-BT demands specialized skills and training. However, accessible a…
pubmed
Iijima K, Okamoto H, Ushijima T, Ueda Y 等
2026 Jun
置信度 0.82
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High biocompatibility and three-dimensional printability of gels make them highly promising for the food industries. Appropriateness of gels for the food industry depends heavily on their mechanical characteristics and molecular dynamics. For identifying dynam…
pubmed
Hashemi B, Assadpour E, Tan C, Jafari SM
2026 Aug 30
置信度 0.82
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Manual segmentation of the whole anterior visual pathway (aVP) from high-resolution magnetic resonance imaging (MRI) is time-consuming and prone to inter-rater variability. We developed and validated a fully automated deep learning framework, "aVP-seg," to per…
pubmed
Diociasi A, Pravatà E, Carmisciano L, Kiersnowski OC 等
2026 Jun 5
置信度 0.82
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Hyperspectral imaging (HSI), characterized by integrated spatial-spectral acquisition, offers a powerful platform for nondestructive and fine-grained forensic evidence analysis. However, high data dimensionality, spectral mixing complexity, and limited forensi…
pubmed
Duan L, Gao S
2026 Jun 5
置信度 0.82
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Modern biology increasingly relies on mathematical and computational modeling to describe complex hierarchically organized biological systems. This review considers models that cover the main levels of biological organization, from the molecular-genetic and ce…
pubmed
Lashin SA, Ivanov RA, Matushkin YG
2026 May
置信度 0.82
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Spatially fractionated radiation therapy (SFRT)-mainly including GRID, LATTICE, minibeam, and microbeam-widens the therapeutic window for bulky or radioresistant tumors. Yet clinical translation faces two persistent hurdles: technical heterogeneity across moda…
pubmed
Bi S, Zhong C, Long Y, Huang Z 等
2026 Jun 4
置信度 0.82
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Object recognition is the ability to discriminate previously encountered objects from novel ones, typically inferred from exploratory preferences. It is usually treated as a form of recognition memory. A central idea is that both nonassociative and associative…
pubmed
Galarce SN, Vogel EH, Keep B, Robinson J 等
2026 Jun 4
置信度 0.82
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Computed tomography remains essential in musculoskeletal imaging, offering superior spatial resolution and contrast for detailed assessment of bone anatomy and fractures, as well as for evaluation in the pre- and postoperative settings. Decades of technologica…
pubmed
Omoumi P, Pastor M, Demehri S, Jarraya M 等
2026 Aug
置信度 0.82
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Recent computational pathology research proposes using artificial intelligence (AI) to infer molecular features from routine haematoxylin-eosin images, aiming to reduce the cost and time associated with biomarker analysis.
pubmed
Montezuma D, Schmitt FC
2026 Jun 4
置信度 0.82
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This review examines the limitations of conventional macroscopic approaches in detecting occult cervical lymph node metastasis (OCLNM). It also explores how multi-omics technologies and artificial intelligence (AI) driven cross-scale multimodal integration are…
pubmed
Lin Y, Hanna E, Pan X, Li G 等
2026 Jun 4
置信度 0.82
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Interstitial pulmonary fibrosis remains a progressive, fatal lung disease with a median survival of approximately 4-5 years in contemporary registry data and limited therapies that slow but do not halt or reverse fibrosis. A fundamental reconceptualization of …
pubmed
Liu X, Li Z
2026 Jun 4
置信度 0.82
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Spatial transcriptomics data are frequently compromised by technical artifacts, such as dry patches, tissue lifting, and uneven reagent coverage, which manifests as regions with low UMI counts, in particular at tissue borders. It can often be challenging to id…
pubmed
He JH, Thompson JR, Totty M, Hicks SC
2026 May 18
置信度 0.82
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Positron emission tomography/computed tomography (PET/CT) has demonstrated significant clinical utility in the localization of infectious foci, yet its application in nephrolithiasis-associated renal infections remains underexplored.
pubmed
Yao X, Ying X, Liu H, Duan C 等
2026
置信度 0.82
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Aortic arch calcification (AoAC) is commonly classified into four grades according to the percentage of calcification observed in clinical practice, and the interpretation is typically based on visual assessment by clinicians. However, this manual evaluation p…
pubmed
Wu CK, Huang CY, Shen TX, Tsai YS 等
2026 Jun 3
置信度 0.82
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Musculoskeletal (MSK) anatomy education is a critical foundation for developing competency among radiologists, physiatrists, rheumatologists, and orthopedic surgeons. However, current undergraduate medical curricula often exhibit significant deficiencies in in…
pubmed
Pidvalna U, Mateshuk-Vatseba L, Tanabayev B, Usen A
2026 Jun 4
置信度 0.82
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Many cancer therapies achieve durable control without complete tumor eradication, suggesting that disrupting tumor organization may be more critical than killing cells. We propose that effective treatments converge by destabilizing the tumor's Group Phenotypic…
pubmed
Thomas F, M Dujon A, Marusyk A, DeGregori J 等
2026 Jun 3
置信度 0.82
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The hippocampus and amygdala play essential roles in human cognition and emotion, through their extensive connectivity with other brain regions and close interaction between them. Uncovering the functional organization of the hippocampus-amygdala complex and i…
pubmed
Liu XS, Vrijsen JN, Yan L, Haak KV 等
2026 Jun 3
置信度 0.82
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In recent years, artificial intelligence in medicine has evolved from single recognition tasks toward structural understanding, spatial reasoning, and clinical interpretability. High-quality anatomical data have become a key factor in further development. Driv…
pubmed
Sun Y, Zhang Q, Zhang W, Liu S 等
2026 Jun 3
置信度 0.82
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The rapid development of antibody-drug conjugates (ADCs), particularly trastuzumab deruxtecan (T-DXd), has renewed interest in more refined assessment of low-end HER2 expression in breast cancer. However, substantial inter-observer variability in manual immuno…
pubmed
Liu J, Zhang X
2026
置信度 0.82
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Single-cell and spatial omics (SPOs) technologies have advanced how healthcare physicians characterise brain tumours by enabling detailed understanding of their cellular architecture, functional states, and microenvironmental dynamics. These approaches provide…
pubmed
Roy S, Nassor M, Zahin F, Chaudhry S 等
2026 Jun 2
置信度 0.82
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Ciliopathies frequently involve abnormal brain development and affected individuals often present with varying degrees of cognitive impairment and behavioral alterations. In parallel, genetic studies have linked primary cilia to neurodevelopmental disorders su…
pubmed
Teoh A, Arinjay M, Giri D, Phua SC
2026 Jun 2
置信度 0.82
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The tumor microenvironment (TME) is composed of diverse heterogeneous components and plays a crucial role in immune cell infiltration, immune evasion, and dynamic interactions between tumor cells and the immune system. A precise understanding of the TME is ess…
pubmed
See JE, Liu Y, Plummer J
2026 Aug
置信度 0.82
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Single-cell transcriptomics has revolutionized our understanding of embryonic liver development by enabling high-resolution dissection of lineage specification and cellular interactions. In this review, we synthesize recent advances from scRNA sequencing, spat…
pubmed
Wang C, Zheng X, Zhu F, Xiang L 等
2026 May 29
置信度 0.82
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Epidemic forecasting plays a vital role in modern public health. The COVID-19 outbreak underscored the critical need for accurate and responsive models. Recent spatio-temporal Graph Neural Network (GNN) models that integrate human mobility networks face challe…
pubmed
Ezzat M, Malek YM, AbdelKader T, Badr N
2026 May 31
置信度 0.82
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In a large Human Connectome Project dataset of 504 females and 452 males performing a 0-back memory task with visual images using the HCP-MultiModalParcellation, faces activated some key cortical regions more (using FDR correction) in females than males, inclu…
pubmed
Zhang R, Rolls ET, Feng J
2026 Jun 1
置信度 0.82
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Habitat suitability of 23 species was modelled using the R package caret (Kuhn 2008) and the software R statistics (R Core Team 2023). The output from this are habitat suitability maps (geotiff format) with a spatial resolution of 250 m and coordinate system o…
datacite
Vishesh L. Diengdoh
2025
置信度 0.66
FOS: Biological sciencesecological niche modelsomniscapehabitat suitabilityamphibian
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Author: Dieter LiedtkeYear: 1970 - 2026Licence: CC BY 4.0 Abstract This study shows that absolute nothingness within space-time (dimensions 1–3) is logically, structurally and epistemologically impossible. The crucial point is not that nothingness "contains in…
datacite
Liedtke, Dieter Walter
2026
置信度 0.66
NothingnessinformationdifferenceGIT, i = E
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Author: Dieter LiedtkeYear: 1970 - 2026Licence: CC BY 4.0 Abstract This study shows that absolute nothingness within space-time (dimensions 1–3) is logically, structurally and epistemologically impossible. The crucial point is not that nothingness "contains in…
datacite
Liedtke, Dieter Walter
2026
置信度 0.66
NothingnessinformationdifferenceGIT, i = E
-
Digital image processing has become a cornerstone of modern scientific and technological systems, supporting a wide range of applications in medicine, industry, remote sensing, security, and autonomous technologies. The rapid growth of imaging devices and comp…
datacite
Hayawi, Heyam A. A.
2026
置信度 0.66
-
Digital image processing has become a cornerstone of modern scientific and technological systems, supporting a wide range of applications in medicine, industry, remote sensing, security, and autonomous technologies. The rapid growth of imaging devices and comp…
datacite
Hayawi, Heyam A. A.
2026
置信度 0.66
-
Dynamic Data Throughput Pipeline Core Framework 1. Executive Manifesto & Overview In the landscape of modern enterprise data architecture, the continuous handling of streaming high-velocity payloads represents a critical structural challenge. Traditional linea…
datacite
Stone, Travis Raymond-Charlie
2026
置信度 0.66
-
Dynamic Data Throughput Pipeline Core Framework and Stone Neural Net 1. Executive Manifesto & Overview In the landscape of modern enterprise data architecture, the continuous handling of streaming high-velocity payloads represents a critical structural challen…
datacite
Stone, Travis Raymond-Charlie
2026
置信度 0.66
-
Space-Filling Curves for Quantum Computing: From Molecular Simulations to Error Correction Mehmet Keçeci ORCID: https://orcid.org/0000-0001-9937-9839 Received: 26.04.2026 Abstract: This study provides a comprehensive review of the versatile applications of spa…
datacite
Keçeci, Mehmet
2026
置信度 0.66
Space-filling curvesSFCquantum computingHilbert curveMorton curve
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Space-Filling Curves for Quantum Computing: From Molecular Simulations to Error Correction Mehmet Keçeci ORCID: https://orcid.org/0000-0001-9937-9839 Received: 26.04.2026 Abstract: This study provides a comprehensive review of the versatile applications of spa…
datacite
Keçeci, Mehmet
2026
置信度 0.66
Space-filling curvesSFCquantum computingHilbert curveMorton curve
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Nexus 2 Framework and Recursive Harmonic Systems: A Unified Theory of Compression, Resonance, and Predictive Computation By Dean Kulik Qu Harmonics. quantum@kulikdesign.com Abstract We present a unified theoretical framework, Nexus 2, that integrates concepts …
datacite
Kulik, Dean A.
2025
置信度 0.66
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Nexus 2 Framework and Recursive Harmonic Systems: A Unified Theory of Compression, Resonance, and Predictive Computation By Dean Kulik Qu Harmonics. quantum@kulikdesign.com Abstract We present a unified theoretical framework, Nexus 2, that integrates concepts …
datacite
Kulik, Dean A.
2025
置信度 0.66
-
This Zenodo repository accompanies the manuscript "Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology". It contains four organized folders with the scripts, input files, and…
datacite
Mukherjee, Sumit, Patiyal, Sumeet, Hoang, Danh-Tai, Ruppin, Eytan
2026
置信度 0.66
-
This Zenodo repository accompanies the manuscript "Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology". It contains four organized folders with the scripts, input files, and…
datacite
Mukherjee, Sumit, Patiyal, Sumeet, Hoang, Danh-Tai, Ruppin, Eytan
2026
置信度 0.66
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Author: Dieter LiedtkeYear: 1970 - 2026Licence: CC BY 4.0 Abstract (short) This study develops an expanded epistemological and physical logic in which entropy and the arrow of time are interpreted not as contradictions to evolution, but as its functional space…
datacite
Dieter Liedtke
2026
置信度 0.66
-
Author: Dieter LiedtkeYear: 1970 - 2026Licence: CC BY 4.0 Abstract (short) This study develops an expanded epistemological and physical logic in which entropy and the arrow of time are interpreted not as contradictions to evolution, but as its functional space…
datacite
Liedtke, Dieter Walter
2026
置信度 0.66
-
Author: Dieter LiedtkeYear: 1970 - 2026Licence: CC BY 4.0 Abstract (short) This study develops an expanded epistemological and physical logic in which entropy and the arrow of time are interpreted not as contradictions to evolution, but as its functional space…
datacite
Liedtke, Dieter Walter
2026
置信度 0.66
-
Dynamic Data Throughput Pipeline Core Framework and Stone Neural Net 1. Executive Manifesto & Overview In the landscape of modern enterprise data architecture, the continuous handling of streaming high-velocity payloads represents a critical structural challen…
datacite
Stone, Travis Raymond-Charlie
2026
置信度 0.66
-
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"Mathematical Proof of the Honeycomb Aether: Deterministic Emergence of 3D Spacetime via Dirac-Mirzakhani Operators" The Fairy Monk Unified Cosmic Engine: Deterministic Prediction of CMB Acoustic Peaks From Micro-Quantum Fluctuations" AND "The World’s First Pu…
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Fairy Monk (Independent Researcher) A=A'
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pythonimport numpy as npimport matplotlib.pyplot as plt# ====================================================================# 1. MAIN COMPUTATIONAL ENGINE (THE PURE CORE) - 400,000 PATHS VERSION# ===============================================================…
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The Ground State of the Typeless Universe: Geometric Constraints, Holonomic Reversibility, and the 3D Mathematical Substrate Driven by Dean Kulik June 2026 1. The Epistemological Crisis and the Ontological Inversion For over a century, the trajectory of contem…
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kulik, dean
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The Ground State of the Typeless Universe: Geometric Constraints, Holonomic Reversibility, and the 3D Mathematical Substrate Driven by Dean Kulik June 2026 1. The Epistemological Crisis and the Ontological Inversion For over a century, the trajectory of contem…
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kulik, dean
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Release Note: V-PCM v1.0.0 ~ Constructive Demonstration of Realizability for Parallel Key Geometric Flow (PKGF) Theory ~ 🌌 Overview This is the initial stable release of the V-PCM (Virtual Photonic Computing Machine) engine. This project serves as a construct…
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Release Note: V-PCM v1.0.0 ~ Constructive Demonstration of Realizability for Parallel Key Geometric Flow (PKGF) Theory ~ 🌌 Overview This is the initial stable release of the V-PCM (Virtual Photonic Computing Machine) engine. This project serves as a construct…
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Miyata, Fumio
2026
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James, Jellinek & Topf 2026 This repository contains the data used in the research paper: James C. B. G, Jellinek A. M. and Topf H. S. Effect of initial source mixing on lock-release turbidity currents with application to deep-sea mining collector plumes In re…
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James, Cara B. G., Jellinek, A. Mark, Topf, Hannah S.
2026
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James, Jellinek & Topf 2026 This repository contains the data used in the research paper: James C. B. G, Jellinek A. M. and Topf H. S. Effect of initial source mixing on lock-release turbidity currents with application to deep-sea mining collector plumes. Subm…
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James, Cara B. G., Jellinek, A. Mark, Topf, Hannah S.
2026
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James, Jellinek & Topf 2026 This repository contains the data used in the research paper: James C. B. G, Jellinek A. M. and Topf H. S. Effect of initial source mixing on lock-release turbidity currents with application to deep-sea mining collector plumes. Subm…
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James, Cara B. G., Jellinek, A. Mark, Topf, Hannah S.
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