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• Glycosaminoglycans in axon growth and regeneration: molecular mechanisms and therapeutic implications.
  Glycosaminoglycans (GAGs) are a structurally and chemically diverse family of sulfated polysaccharides that constitute a major component of the neural extracellular matrix and cell surface proteoglycans, where they exert pivotal regulatory functions in axon gr…
  pubmed Sakamoto K, Nagai Y, Kadomatsu K 2026 置信度 0.82
• Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.
  Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current management is largely …
  pubmed Sun Y, Yang X, Zhu Q, Yang R 2026 置信度 0.82
• Selective carbon-carbon bond cleavage involving alkene moieties.
  The selective cleavage of carbon-carbon (C-C) bonds has emerged as a powerful tool for molecular deconstruction and skeletal editing. However, the inherent strength and low polarity of C-C bonds render their selective scission a formidable challenge. Alkenes a…
  pubmed Qin Q, An XD, Hao S, Jiao N 2026 Aug 4 置信度 0.82
• A Global View on the use of Synthetic Peptides in ELISA-Based Serodiagnosis of Human Infectious Diseases.
  The development of accurate and efficient diagnostic methods is essential to optimize the quality of life of patients. Serological methods using pathogenic antigens have demonstrated high performance in various applications. The use of synthetic peptides as an…
  pubmed Lopes LDS, Ribeiro AJ, Silva BLN, Cassiano CSS 等 2026 Jun 23 置信度 0.82
• Recent advances in protein engineering and synthetic applications of amino acid oxidases.
  Amino acid oxidases (AAOs: EC 1.4.3.X, D- and l-forms) have attracted significant interest as promising biocatalysts for the synthesis of high-value chiral compounds, including natural and non-natural amino acids. These FAD-dependent enzymes catalyze the oxida…
  pubmed Israr M, Basheer F, Zhou Y, Zeeshan M 等 2026 Nov 置信度 0.82
• Engineering the esophagus: advances, challenges, and translational pathways in esophageal tissue reconstruction.
  Esophageal reconstruction is one of the most challenging procedures in gastrointestinal surgery. While conventional therapeutic approaches, such as gastric pull-up and intestinal interposition, can restore continuity, they often fail to replicate native physio…
  pubmed Nemati A, David A, Zhang Y, Savoji H 等 2026 Jul 20 置信度 0.82
• High-throughput machine learning-aided antibody discovery for cell surface antigens.
  Machine learning (ML) has the potential to revolutionize antibody design and selection, but its success depends on access to well-curated datasets of antibody-antigen interactions. We developed a synthetic Fab yeast display library optimized for seamless integ…
  pubmed Kothiwal D, Kollasch AW, Anuganti M, Hollmer N 等 2026 Aug 19 置信度 0.82
• Integrated control of redox and energy metabolism by the membrane-bound and soluble transhydrogenases of Pseudomonas putida across metabolic regimes.
  Redox homeostasis underpins microbial physiology and stress adaptation, yet the extent to which transhydrogenases contribute to these processes remains largely unexplored in most organisms. In this study, we reveal how Pseudomonas putida integrates two distinc…
  pubmed Partipilo M, Favoino G, Puiggené Ò, Rocha C 等 2026 Aug 19 置信度 0.82
• Recent progresses in cancer multidrug resistance and therapeutic options associated with protein damage response.
  Multidrug resistance (MDR) is a common and leading cause of treatment failure and mortality in cancer patient. While numerous biological processes contribute to drug resistance, recent studies have revealed that most anticancer drugs rapidly bind to and damage…
  pubmed Shao F, Tang D, Li L, Xu X 等 2026 Jun 23 置信度 0.82
• Tangled Tail of Mechanically Interlocked Peptides.
  First synthesized by chemists in the 1960s, mechanically interlocked molecules (MIMs) were created out of scientific curiosity and thought only to be academic oddities. However, naturally occurring interlocked biomolecules were subsequently discovered, highlig…
  pubmed Johnson TG, Link AJ 2026 Jul 8 置信度 0.82
• Recent advances in the development of small molecule STK33 inhibitors.
  The serine/threonine kinase 33 (STK33) has attracted attention in recent years as a synthetic-lethal partner of oncogenic KRAS, thereby representing a potential indirect route to target KRAS-driven cancers. Initially, RNAi screens suggested that STK33 inhibiti…
  pubmed Upadhyay DB, Parmar MP, Patel HM 2026 Aug 置信度 0.82
• β-Casomorphins as opioid peptide modulators of tumor biology and immune signaling.
  β-casomorphins (BCMs) are bioactive peptides generated from milk β-casein digestion, which interact with opioid and other receptors to affect both tumor cell proliferation and immune responses within the tumor microenvironment. This review is aimed…
  pubmed Kamysz W, Małek K, Kleczkowska P 2026 Jul 15 置信度 0.82
• Overcoming cellular secretion bottlenecks: advanced secretion engineering and molecular tailoring for next-generation microbial α-amylases with enhanced industrial performance.
  α-amylases are indispensable industrial biocatalysts, yet their recombinant production faces significant biochemical and cellular bottlenecks. Recent scientific advancement shifts the paradigm from traditional cloning toward a design-parameter framework,…
  pubmed Ahmad S, Aftab MN, Ghalib M, Aslam MS 2026 Jun 22 置信度 0.82
• Exploring the antiviral and antibacterial properties of zeolites across various industry applications.
  Metal-exchanged zeolites have emerged as versatile platforms for antimicrobial and antiviral applications due to their tunable pore architecture, cation exchange capacity (CEC), and ability to provide controlled metal ion release. This review critically evalua…
  pubmed Amari S, Boshrouyeh R, Darestani M 2026 Jul 置信度 0.82
• Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review.
  Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and …
  pubmed Kamra K, Lalam SK, Srivastava S, Arumugam MK 等 2026 Jun 置信度 0.82
• From Nature to Innovation: Exploring Natural Biopolymers in 3D Bioprinting for Bone Regeneration.
  Critical bone defects represent a global health challenge, necessitating specialized medical care and imposing significant costs on the public systems. In this context, many efforts in the tissue engineering and regenerative medicine framework have been made, …
  pubmed Barros RM, Oliveira ACJ, Chaves LL, Leão AD 等 2026 Jun 16 置信度 0.82
• Streptomyces: boost chassis strains for production of invaluable natural products.
  Streptomyces species continue to occupy a pivotal role in natural product biosynthesis, owing to their unparalleled metabolic diversity and genetic adaptability. This review focuses on cutting-edge advances documented from 2020 to 2025 (encompassing approximat…
  pubmed Chen S, Ling S, Li J, Liu Z 等 2026 Dec 置信度 0.82
• Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods.
  Native chemical ligation (NCL) represents a powerful strategy for the chemical synthesis of tailor-made proteins that are difficult to obtain via biological expression approaches. Early desulfurization methods, particularly VA-044-based desulfurization, have p…
  pubmed Ding X, Li C, Wang X, Liang LJ 2026 Jul 15 置信度 0.82
• Recent Progress in the Total Synthesis and Biosynthesis of Arborisidine.
  As a significant representative of monoterpenoid indole alkaloids (MIAs) and 1,1-disubstituted tetrahydro-β-carboline (THβC) alkaloids, Arborisidine, since its discovery in 2016 by Kam and coworkers, has emerged as a focal molecule in the field of …
  pubmed Dong S, Shi K, Guo J, Li L 2026 Jul 置信度 0.82
• Advances and challenges in alternative proteins: From biotechnology to sustainable food production.
  Global demand for meat is expected to increase by up to 50% by 2050. This crisis cannot be ameliorated by blindly increasing animal meat production. Innovative approaches are needed to replace or complement animal proteins, ensuring global access to safe, high…
  pubmed Zhang C, Wu X, He Q, Chen J 等 2026 Oct 置信度 0.82
• Recent advances in the microbial production of L-arginine and its derivatives using engineering Corynebacterium glutamicum and Escherichia coli.
  L-arginine, a semi-essential alkaline amino acid, is widely utilized across industries such as food, feed, cosmetics, and pharmaceuticals. The primary industrial production strains for L-arginine are Corynebacterium glutamicum and Escherichia coli. The highest…
  pubmed Sheng Q, He S, Xu W, Guo Y 等 2026 Oct 置信度 0.82
• The diverse effects of stress in cross-feeding systems.
  Predicting how metabolically interdependent microbial communities will respond to stress is an important but difficult challenge. Synthetic microbial communities provide an important tool for identifying mechanisms that impact stress response in communities. I…
  pubmed Hill CA, Lee AR, Harcombe WR 2026 Aug 置信度 0.82
• Global reports on Glutamicibacter: a mini review.
  Glutamicibacter has been recently reclassified from the genus Arthrobacter and represents a rare group of actinobacteria with significant biotechnological potential. Based on 16S rRNA signatures and phylogenomic evidence, its species have been discovered in di…
  pubmed Ganesapandi V, Kavitha R 2026 Feb 28 置信度 0.82
• Comparative cytogenotoxicity and physiological stress endpoints of a Trichoderma asperellum-based biopesticide versus mancozeb and abamectin in plant bioassays.
  The global transition toward sustainable agricultural systems has intensified the search for fungal-based biopesticides, such as Trichoderma asperellum, to replace synthetic pesticides. Although considered safer, these products are not biologically inert and m…
  pubmed de Souza VV, de Andrade LR, Trujillo FA, Fontes MMP 等 2026 Oct 1 置信度 0.82
• Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.
  Wine fermentation remains inherently variable because of the genetic and phenotypic diversity of Saccharomyces cerevisiae and non-Saccharomyces yeasts, microbial interactions, and climate-driven shifts in grape composition, challenging predictable and low-inte…
  pubmed Kutyna DR, Pretorius IS 2026 Aug 置信度 0.82
• Trichoderma as a biological control agent against Colletotrichum-associated plant diseases: current insights and future perspectives.
  Colletotrichum species are a taxonomically complex group of hemibiotrophic fungi that cause anthracnose diseases, posing a major constraint to global crop productivity. Their broad host range, high genetic diversity, and ability to shift between biotrophic and…
  pubmed Adhitya R, Miranti M, Jefferson TA, Albert M 等 2026 Dec 31 置信度 0.82
• Progresses of transposon research in Saccharomyces cerevisiae.
  Transposons are mobile genetic elements that have attracted sustained scientific interest since their discovery in maize, evolving into indispensable tools in genetic research. Saccharomyces cerevisiae serves as a preferred model for transposon studies, benefi…
  pubmed Lin W, Lv Y, Zhang Y, Jin Z 等 2026 Dec 置信度 0.82
• The three pathways of advanced glycation end product synthesis: Hodge, Namiki, and Wolff - a clinically oriented mechanistic synthesis with network-based implications.
  Advanced Glycation End Products (AGEs) accumulate under chronic hyperglycemia and contribute to type 2 diabetes mellitus (T2DM) complications. Three chemical routes generate AGEs in vivo : the Hodge pathway (Amadori rearrangement), the Namiki pathway (Schiff b…
  pubmed Fernandez EC 2026 置信度 0.82
• T-cell engagers in cancer immunotherapy: mechanisms, challenges, and future perspectives.
  T-cell engagers (TCEs) are a rapidly evolving class of cancer immunotherapies that redirect cytotoxic T cells to tumor-associated antigens independently of MHC presentation. This review outlines the development, structural formats, and therapeutic potential of…
  pubmed Muthughavi K, Khokhar M, Jha HC, Pandey RK 2026 置信度 0.82
• Rewiring cell death and evading repair: Evolution of temozolomide and emerging strategies against resistant glioblastoma.
  Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor, characterized by a universally dismal prognosis. For over two decades, the alkylating agent temozolomide (TMZ) has remained the cornerstone of the standard-of-care "Stupp proto…
  pubmed Wang L, Zhen T, Liu H, Sun P 等 2026 Oct 15 置信度 0.82
• Recent advances in glycoconjugate-based therapeutics.
  Glycoconjugates are central mediators of molecular recognition in biological systems, yet their inherent structural microheterogeneity has long impeded mechanistic insight and therapeutic translation. Recent advances in synthetic chemistry, chemoenzymatic appr…
  pubmed Dao Y, Dong S 2026 Aug 置信度 0.82
• Resistance-centered pharmacology of DNA damage response-targeted therapy: Mechanisms, predictive biomarkers, and biomarker-guided adaptive treatment strategies in solid tumors.
  DNA damage response (DDR)-targeted agents, particularly poly(ADP-ribose) polymerase inhibitors (PARPi), have transformed treatment of homologous recombination (HR)-deficient solid tumors. Yet inevitable therapeutic resistance limits durability of clinical bene…
  pubmed Qin S, An J, Qiao W, Zhichao X 等 2026 Aug 置信度 0.82
• Bacterial Laccase: Recent Advances in Production, Engineering Strategies, and Diagnostic Applications.
  Bacterial laccases are multicopper oxidase enzymes that are able to catalyze the oxidation reaction of phenolic and non-phenolic substrates followed by the reduction reaction of molecular oxygen to water as the only byproduct. It exhibits high stability under …
  pubmed Mardiyono FW, Putri BSA, Fuad AM, Herawati N 等 2026 Jun 18 置信度 0.82
• Regenerative Potential of Platelet-Rich Plasma-Loaded Scaffolds in Endometrial Damage: A Meta-Analysis.
  This systematic review and meta-analysis evaluated the efficacy of platelet-rich plasma (PRP)-loaded scaffolds for endometrial regeneration in preclinical in vivo models. Endometrial damage, manifesting as endometrial thinning or adhesion formation within…
  pubmed Mirzohreh ST, Mohammadi Z, Jahanbani Y, Dehghan M 等 2026 Jun 17 置信度 0.82
• De-extinction: how reviving the past is revolutionizing the future of conservation biology.
  Human activity is driving a biodiversity crisis marked not only by accelerating species extinctions but also by rapid erosion of genetic and phylogenetic diversity. De-extinction science has emerged in response. Here, we synthesize de-extinction as a conservat…
  pubmed Hutchison JC, Moon KL, Abri S, Walsh J 等 2026 置信度 0.82
• A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights.
  Mitragyna species, known for their diverse traditional uses across various Asian countries, have gained scientific interest due to their pharmacological properties and rich phytochemical composition. This paper presents an updated overview of nine Mitragyna sp…
  pubmed Wangmo KS, Wungsintaweekul J, Zhu Z, Yang M 等 2026 Jun 置信度 0.82
• Superfolder Green Fluorescent Protein (sfGFP): A Versatile Tool for Biotechnology Research.
  Superfolder green fluorescent protein (sfGFP) is an engineered GFP variant best known for its robust folding, reliable chromophore maturation, and high tolerance to fusion partners. This review argues that the principal value of sfGFP lies not in universal sup…
  pubmed Ding Y, Duan X, Liu Q, Wu J 等 2026 Jun 17 置信度 0.82
• Butyrate-Producing Bacteria in Intestinal Disease Therapy: Potential and Challenges.
  Butyrate-producing bacteria have emerged as keystone species whose metabolic activity orchestrates host-microbial homeostasis in the human gut. This review synthesizes current understanding of how these anaerobic Firmicutes, including Faecalibacterium prausnit…
  pubmed Zhang F, Zhang W, Ren X, Liu B 等 2026 Jun 置信度 0.82
• The trinity of T cell engagement: navigating the molecular and clinical landscape of CAR-T, TILs, and TCEs in the war against cancer.
  The advent of cancer immunotherapy has fundamentally restructured the oncological paradigm, moving away from agents that directly target tumor cell kinetics toward strategies that empower the host immune system to recognize and eliminate malignancy. Central to…
  pubmed Yang Q, Wang S, Liu F, Yu Y 等 2026 置信度 0.82
• Metabolism and regulation of chlorophyll and carotenoids in tomato fruits.
  Tomato ( Solanum lycopersicum ) is a nutrient-rich and flavorful vegetable, ranking among the most consumed globally. In recent years, consumers have increasingly demanded high-quality tomatoes, prompting the extensive research into the key factors and relevan…
  pubmed Zhang W, Xie Y, Yuan Y, Long Q 等 2026 Jul 置信度 0.82
• Breaking the photosynthetic monopoly on carbohydrate production through artificial synthesis.
  Photosynthesis has maintained an evolutionary monopoly on biological carbohydrate production for over 3.5 billion years, yet its fundamental limitations, including poor solar conversion efficiency, spatial constraints, and temporal variability, increasingly co…
  pubmed Weng C, Liang Y, Liu S, Deng Z 等 2026 Oct 置信度 0.82
• Computationally guided design of molecularly imprinted polymers for electrochemical biosensing interfaces.
  Rapid, accurate, and on-site detection of foodborne pathogens remains a critical challenge in ensuring food safety. Traditional microbiological methods, including culture-based assays, ELISA, and PCR, often require long processing times, specialized equipment,…
  pubmed Şahin K, Savaş S 2026 Aug 置信度 0.82
• Beyond component optimization: systems-level biodesign for lanthanide recovery.
  While global demand for lanthanides (Ln) is projected to rise sharply over the next decade, geographically concentrated supply chains that are sensitive to disruption create a major bottleneck for meeting future needs. Secondary feedstocks offer a potential al…
  pubmed Beliaev AS, Stegen JC, Burnum-Johnson KE, Hanikel N 等 2026 Aug 置信度 0.82
• Penetrating the cell wall: a review on delivering exogenous materials into plant and fungal cells via micro/nanoinjection.
  Intracellular delivery into walled cells is essential for advancing research in plant science, microbiology, and synthetic biology. Conventional enzymatic wall degradation methods are inherently destructive, leading to poor cell survival. Micro/nanoinjection t…
  pubmed Xu F, Yu J, Zhang Z, Chen J 等 2026 Jul 23 置信度 0.82
• Inorganic nanomaterials empowering bacteria: a new paradigm for biomedical applications.
  Bacterial therapy holds great potential in biomedicine, but its clinical application is hindered by challenges such as in vivo instability and biosafety concerns. Inorganic nanomaterials, with their excellent structural stability, multifunctional characteristi…
  pubmed Chen Z, Hou X, Wang S, Qi G 等 2026 Jul 1 置信度 0.82
• The sulfo-click reaction: expanding the toolbox for bioconjugation and medicinal chemistry.
  The sulfo-click reaction, which relies on the chemoselective coupling of sulfonyl azides with thioacids to yield N -acylsulfonamides, has emerged as a powerful and versatile transformation in synthetic chemistry and bioconjugation. Its high efficiency, operati…
  pubmed Amador R, Smietana M, Clavé G 2026 Jun 23 置信度 0.82
• Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities.
  Covering: 1944-2025Nature's biosynthetic repertoire extends far beyond conventional CHON(S) chemistry and encompasses a rare but diverse array of natural products that incorporate atypical elements such as arsenic, selenium, fluorine, iodine, boron, and vanadi…
  pubmed Lee YJ, Hwang HJ, Lee J, Park HS 等 2026 Jun 4 置信度 0.82
• Genetically engineered outer membrane vesicles as next-generation bionanomaterials for therapeutic and diagnostic applications.
  Outer membrane vesicles (OMVs), naturally released by Gram-negative bacteria, represent a unique class of bionanomaterials with inherent immunogenicity, efficient cellular delivery, and scalable production. However, their native toxicity, compositional heterog…
  pubmed Bian X, Huang Z, Xu C, Yue J 等 2026 Jun 23 置信度 0.82
• The division of vesicles requires the fission of closed membrane necks but does not require active processes.
  One important objective of soft matter science and synthetic biology is to construct synthetic systems and processes that mimic the division of cells and organelles. Such division processes have been achieved experimentally for giant vesicles and in silico for…
  pubmed Lipowsky R 2026 Aug 26 置信度 0.82
• Status, scale-up and microbial genes perspective in microbial electrosynthesis for multi-step carbon dioxide upgrading to value-added products.
  Increased atmospheric carbon dioxide (CO 2 ) emissions in the atmosphere due to excessive usage of fossil fuels, rapid industrial development and human growth have raised a global interest in the greenhouse effect. CO 2 conversion is important not just because…
  pubmed Singhal S, Gupta J, Rani V, Zainab M 等 2026 Jul 置信度 0.82
• Synthetic Strategies for Mono-Carbonyl Curcumin Analogues: Reaction Optimisation, Substituent Influence, and Emerging Sustainable Methods.
  Curcumin, a natural polyphenolic compound with broad pharmacological potential, continues to attract interest for its diverse bioactivities. However, its clinical application is hindered by poor stability and low bioavailability. To address these limitations, …
  pubmed Loh ZH, Jantan I, Wai Lam K, Ng JF 等 2026 Apr 1 置信度 0.82
• Targeting the phenolic A-ring unifies the toxicology and remediation of environmental estrogens in aquatic environments.
  Environmental estrogens (EEs) pose risks to aquatic ecosystems and human health through their endocrine-disrupting potential, effects that are often shaped by recurring estrogen-mimetic structural features, including the phenolic A-ring in steroidal estrogens …
  pubmed Yu LF, Ye YL, Zhou J, Jin YH 等 2026 Sep 1 置信度 0.82
• Programmable methylation engineering: Design principles from alkaloid biosynthesis.
  Methyltransferases (MTs) play a central role in alkaloid biosynthesis by catalyzing methylation reactions that critically shape scaffold diversification, bioactivity, solubility, and pharmacokinetic properties. However, their application in methyltransferase-t…
  pubmed Zhou H, Shen X, Wang J, Sun X 等 2026 Oct 置信度 0.82
• Systems biology of yeast metabolism.
  Metabolism underpins cellular function by supplying energy, biosynthetic precursors, and redox balance and in yeast there are thousands of metabolic reactions that are tightly coordinated through multilayered regulation. The yeast Saccharomyces cerevisiae has …
  pubmed Nielsen J 2026 Jan 5 置信度 0.82
• Synthetic short RNA in cancer.
  Small RNAs play an important role in many biological processes. They vary widely in size and form, including single- and double-stranded RNAs. Synthetic short RNAs are very powerful tools for modulating or intervening in cellular biology, and many types of art…
  pubmed Tomita T, Minagawa K, Hiratsuka S 2026 置信度 0.82
• Solanaceous vegetables and Fusarium oxysporum interactions: pathogen genomics, pathogenesis, host resistance, and emerging microbiome-driven disease management.
  Solanaceous vegetables are continuously threatened by Fusarium wilt disease, which is mainly caused by Fusarium oxysporum ( Fo ), a fungal species complex comprising many devastating soil-borne pathogens, resulting in severe yield losses worldwide. Over the pa…
  pubmed Li M, Hao L, Shi X, Wang J 等 2026 Jun 置信度 0.82
• Therapeutic potential of growth hormone-releasing hormone analogues in cardiovascular and cerebrovascular diseases: mechanisms and preclinical evidence.
  Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide that stimulates growth hormone (GH) secretion from the pituitary gland, forming the central GHRH-GH-insulin-like growth factor-1 (IGF-1) endocrine axis. Beyond its classical endocrine funct…
  pubmed Ren HL, Zhang Y, Yang K, Zhang L 等 2026 置信度 0.82
• Engineering next-generation organoids: A review on bioprinting strategies, bioink innovations, and frontier applications.
  While organoids hold immense promise as in vitro three-dimensional (3D) models, their translational utility is fundamentally constrained by passive diffusion limits (>800 μm), which inevitably trigger necrotic core formation and stochastic structural …
  pubmed Sun D, Fan X, Sun H, Li D 等 2026 Jan-Dec 置信度 0.82
• Harnessing natural variation for photosynthetic improvement in next-generation crop breeding.
  Because agriculture is confronted with escalating climatic and resource challenges, next-generation breeding requires innovative strategies to sustain and enhance crop productivity. As the foundation of carbon fixation in plants, photosynthesis strongly affect…
  pubmed Zhou Y, Li X, Wei S, Soualiou S 等 2026 Aug 置信度 0.82
• From agri-food wastes to high-value products: research progress, technological innovation, and challenges in the resource recycling of Chinese Baijiu by-products.
  Against the backdrop of tightening resource constraints, intensifying ecological pressures, policy guidance, and cutting-edge technological advancements, the global distilled spirits industry faces a critical sustainability challenge: how to efficiently utiliz…
  pubmed Zhang C, Wu J, Huang M, Sun B 等 2026 Oct 置信度 0.82
• From fermentation to pharmabiotics: engineering kefir-derived Lactobacillus for targeted intratumoral immunotherapy in colorectal Cancer.
  Colorectal cancer (CRC) is a leading cause of cancer-related death, and most patients benefit little from immune checkpoint inhibitors (ICIs) because microsatellite-stable (MSS) tumors are largely resistant to them. In this context, this review aims to address…
  pubmed Saikia T, Das S, Rajak P, Kalita JM 2026 Sep 15 置信度 0.82
• Engineering Lactobacillus for therapeutic delivery and biosensing: lessons from niche adaptation.
  Lactobacillus species are renowned for their probiotic properties and niche adaptability, driven by unique genomic traits, stress-response mechanisms, and biofilm formation. This versatility makes them exceptional candidates for advanced biotechnological appli…
  pubmed Pal P, Sarkar S, Rajak J, Maitra S 等 2026 Jun 置信度 0.82
• Transplantation of encapsulated fecal microbiota: research progress and future trends.
  Fecal microbiota transplantation (FMT) demonstrates significant efficacy in treating intestinal disorders, such as recurrent Clostridioides difficile infection (rCDI). However, traditional FMT relies on invasive delivery methods (e.g., colonoscopy or use of a …
  pubmed Lin ML, Gao HN 2026 Jun 13 置信度 0.82
• Recent advances in microbial production of S-adenosyl-L-methionine and its high-value derivatives.
  S-Adenosyl-L-methionine (SAM or AdoMet) is a central metabolic hub linking methylation, transsulfuration, and polyamine metabolism. It also serves as the universal methyl donor or aminopropyl donor in the biosynthesis of diverse high-value compounds. This pivo…
  pubmed Liao Y, Shi Z, Wang X, Zhang C 等 2026 Oct 置信度 0.82
• Bridging cells with devices: emerging reporters and physical interfaces for bacterial biosensors.
  Bacterial biosensors have emerged as versatile platforms for biomedical and environmental applications, yet their real-world deployment is constrained by limited signal readouts and weak integration with external devices. Two complementary research directions …
  pubmed Capin J, Sasson C, Cattoni DI, Bonnet J 2026 Aug 置信度 0.82
• Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells.
  Glycerophospholipids (GPLs) constitute one of the most important subclasses of phospholipids. These biomolecules are known to play multiple roles at the cellular level and are also involved as major constituents in membrane bilayers, cellular compartmentalizat…
  pubmed Beauvais B, Rohokale R, Mamputu S, Lupu I 等 2026 Jun 15 置信度 0.82
• Recent Advances in the Construction of Allylic All-Carbon Quaternary Stereocenters via π-Allyl Metal Intermediates.
  All-carbon quaternary stereogenic units are prevalent structural motifs in natural products and pharmaceutical molecules. Due to the immense steric hindrance arising from four carbon substituents, their catalytic asymmetric synthesis has remained a focal point…
  pubmed Yan X, Tang Z, Liu Y 2026 Jun 13 置信度 0.82
• THE FUNCTIONAL BIOGEOGRAPHY OF REPRODUCTIVE STRUCTURES IN OPILIONES (ARACHNIDA); MATING PHENOLOGY AND ITS IMPACT ON THE EVOLUTION OF SEXUAL CONFLICT.
  Abiotic and ecological factors such as temperature and precipitation can significantly impact the expression and evolution of reproductive traits. The mechanism through which this impact manifests may vary between different taxa, but sexual conflict, wherein m…
  datacite Bacon, Ryan Andrew 2026 置信度 0.66 ArachnidaBreeding SeasonFunctional BiogeographyLocal AdaptationNeotropical
• Interdisciplinary Insights Into Modern Drug Delivery Platforms: Engineering, Biology, And Medicine
  The field of drug delivery has experienced a paradigm shift in recent decades, driven by collaborations across engineering, biology, and medicine. Traditional pharmaceutical formulations are being replaced by advanced delivery systems designed to optimise phar…
  datacite Prerna Vijay Thete*, Sadhna Pandurang Thete, Vaishnavi Niranjan Vaidya, Sable Rutuja Bhaurao, Mukund Mahadev Pache 2026 置信度 0.66 Interdisciplinary drug delivery, nanomedicine, biomaterials, translational medicine, controlled release, precision therapy, microfluidics, immune evasion.
• Interdisciplinary Insights Into Modern Drug Delivery Platforms: Engineering, Biology, And Medicine
  The field of drug delivery has experienced a paradigm shift in recent decades, driven by collaborations across engineering, biology, and medicine. Traditional pharmaceutical formulations are being replaced by advanced delivery systems designed to optimise phar…
  datacite Prerna Vijay Thete*, Sadhna Pandurang Thete, Vaishnavi Niranjan Vaidya, Sable Rutuja Bhaurao, Mukund Mahadev Pache 2026 置信度 0.66 Interdisciplinary drug delivery, nanomedicine, biomaterials, translational medicine, controlled release, precision therapy, microfluidics, immune evasion.
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• BangunPunya/aware-costFBA: aware-costFBA
  A resource-aware flux balance for ranking generative-model DNA designs in Escherichia coli metabolic engineering" (submitted to ACS Synthetic Biology). Pre-release snapshot for peer review. Not the final archival version. Contents Resource-aware (enzyme-constr…
  datacite BangunPunya 2026 置信度 0.66
• BangunPunya/aware-costFBA: aware-costFBA
  A resource-aware flux balance for ranking generative-model DNA designs in Escherichia coli metabolic engineering" (submitted to ACS Synthetic Biology). Pre-release snapshot for peer review. Not the final archival version. Contents Resource-aware (enzyme-constr…
  datacite BangunPunya 2026 置信度 0.66
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• A Comprehensive Review on Taxus Plant: Phytochemistry, Pharmacology and Therapeutic Potential
  The Taxus genus, commonly known as yew, represents one of the most significant sources of naturally derived anticancer compounds, particularly paclitaxel (Taxol). Recent advances in plant biotechnology, synthetic biology, and metabolic engineering have enhance…
  datacite Sanika Patil*, Dr. Mahesh Thorat, Dr. Raghunath Jadge, Rutuja More, Anjali Mohite 2026 置信度 0.66 Taxus, paclitaxel, secondary metabolites, biotechnology, endophytes, pharmacology, sustainable production
• A Comprehensive Review on Taxus Plant: Phytochemistry, Pharmacology and Therapeutic Potential
  The Taxus genus, commonly known as yew, represents one of the most significant sources of naturally derived anticancer compounds, particularly paclitaxel (Taxol). Recent advances in plant biotechnology, synthetic biology, and metabolic engineering have enhance…
  datacite Sanika Patil*, Dr. Mahesh Thorat, Dr. Raghunath Jadge, Rutuja More, Anjali Mohite 2026 置信度 0.66 Taxus, paclitaxel, secondary metabolites, biotechnology, endophytes, pharmacology, sustainable production
• Engineered Membrane Vesicle Production via oprF or oprI Deletion Has Distinct Phenotypic Effects in Pseudomonas putida
  Membrane vesicle (MV) production is a natural phenomenon in Gram-negative bacteria and represents an emerging synthetic biology tool for the secretion of biomolecules or bioproducts. Manipulation of membrane components has proven successful in enhancing MV pro…
  datacite Wilkes, Rebecca A., Miller, Tarryn E., Waldbauer, Jacob, Zhou, Nanqing 等 2025 置信度 0.66 Membrane VesiclesOuter Membrane VesiclesHypervesiculationProteomicsProtein Secretion
• Engineered Membrane Vesicle Production via oprF or oprI Deletion Has Distinct Phenotypic Effects in Pseudomonas putida
  Membrane vesicle (MV) production is a natural phenomenon in Gram-negative bacteria and represents an emerging synthetic biology tool for the secretion of biomolecules or bioproducts. Manipulation of membrane components has proven successful in enhancing MV pro…
  datacite Wilkes, Rebecca A., Miller, Tarryn E., Waldbauer, Jacob, Zhou, Nanqing 等 2025 置信度 0.66 Membrane VesiclesOuter Membrane VesiclesHypervesiculationProteomicsProtein Secretion
• From sequence to structure: A comprehensive review of deep learning models for RNA structure prediction
  RNA structure prediction remains one of the most challenging problems in computational biology, with significant implications for understanding gene regulation, drug design, and synthetic biology. While deep learning has revolutionized protein structure predic…
  datacite Upadhyay, Utkarsh, Dorn, Anton, Faber, Christian, Schug, Alexander 2026 置信度 0.66
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• Engineering precision therapies: lessons and motivations from the clinic
  In the past decade, gene- and cell-based therapies have been at the forefront of the biomedical revolution. Synthetic biology, the engineering discipline of building sophisticated ‘genetic software’ to enable precise regulation of gene activities in living cel…
  datacite Xie, Mingqi, Viviani, Mirta, Fussenegger, Martin 2021 置信度 0.66 translational medicinesynthetic biologycell-based therapiesgene therapyATMP
• Current Progress and Future Outlook for Synthetic Gene Circuits in Cardiovascular Therapy
  Despite decades of therapeutic advances, cardiovascular diseases remain the leading cause of global mortality, underscoring the need for strategies that move beyond untargeted systemic pharmacotherapy. Synthetic biology introduces a programmable therapeutic pa…
  datacite Khalilitousi, Mohammadali, Dhingra, Arshaan, Rohani, Leili, Weiss, Ron 2026 置信度 0.66
• Synthetic biology
  Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we review t…
  datacite Heinemann, Matthias, Panke, Sven 2006 置信度 0.66
• Chemical Approaches in Life Sciences for Isoxazole
  Abstract Because of its wide range of biological activities and synthetic versatility, isoxazole—a five-membered heterocyclic scaffold with nearby nitrogen and oxygen atoms—has become a special and adaptable structure in the life sciences. The design, synthesi…
  datacite Shinde, Yogesh, Bangale, Sachin 2026 置信度 0.66 Keywords: Isoxazole; Heterocyclic compounds; Medicinal chemistry; Chemical biology; Bioisosterism; Drug design; Structure–activity relationship (SAR); Structure-Based Drug Design (SBDD); Anticancer activity; Green synthesis; Photoredox catalysis; Electrochemical synthesis; Multicomponent reactions; Nanotechnology; Computational chemistry; Molecular docking; Drug discovery.
• Chemical Approaches in Life Sciences for Isoxazole
  Abstract Because of its wide range of biological activities and synthetic versatility, isoxazole—a five-membered heterocyclic scaffold with nearby nitrogen and oxygen atoms—has become a special and adaptable structure in the life sciences. The design, synthesi…
  datacite Shinde, Yogesh, Bangale, Sachin 2026 置信度 0.66 Keywords: Isoxazole; Heterocyclic compounds; Medicinal chemistry; Chemical biology; Bioisosterism; Drug design; Structure–activity relationship (SAR); Structure-Based Drug Design (SBDD); Anticancer activity; Green synthesis; Photoredox catalysis; Electrochemical synthesis; Multicomponent reactions; Nanotechnology; Computational chemistry; Molecular docking; Drug discovery.
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• Information Field Density as a Testable Cross-Scale Organizing Quantity for Chemical and Biological Order
  Living systems are usually described by separate theories for bonding, energy flow, replication, repair, selection and failure. I propose information field density, denoted rho_I, as an operational cross-scale organizing quantity whose basal carrier is connect…
  datacite ARIKAN, FURKAN 2026 置信度 0.66 information field density molecular geometry biological organization origin of life synthetic cells systems biology chirality aging disease biological phase transition
• NATURAL SOURCES IN SKIN CARE AND DERMATOLOGICAL THERAPY: A COMPREHENSIVE REVIEW
  Human skin functions as the primary protective barrier against physical, chemical, microbial, and ultraviolet-induced damage while also contributing to thermoregulation, sensory perception, and immunological defense. Increasing concerns regarding the adverse e…
  datacite Rishita Bhawsar1, Vishesh Dubey1, Manoj Goyal 2026 置信度 0.66
• NATURAL SOURCES IN SKIN CARE AND DERMATOLOGICAL THERAPY: A COMPREHENSIVE REVIEW
  Human skin functions as the primary protective barrier against physical, chemical, microbial, and ultraviolet-induced damage while also contributing to thermoregulation, sensory perception, and immunological defense. Increasing concerns regarding the adverse e…
  datacite Rishita Bhawsar1, Vishesh Dubey1, Manoj Goyal 2026 置信度 0.66
• Diagnostic Convergences of The Janus Machine: Independent Derivation and the Structure of Life, Mind, and Meaning
  The Janus Machine is a hardware-first synthetic organismic architecture for cognition, developed from first principles. This paper maps 33 diagnostic convergences between the architecture and established frameworks across 8 disciplines: philosophy, biology, cy…
  datacite Janus, Anthony 2026 置信度 0.66 EnactivismAutopoiesisBioelectric CognitionDissipative StructuresConatus
• Diagnostic Convergences of The Janus Machine: Independent Derivation and the Structure of Life, Mind, and Meaning
  The Janus Machine is a hardware-first synthetic organismic architecture for cognition, developed from first principles. This paper maps 33 diagnostic convergences between the architecture and established frameworks across 8 disciplines: philosophy, biology, cy…
  datacite Janus, Anthony 2026 置信度 0.66 EnactivismAutopoiesisBioelectric CognitionDissipative StructuresConatus
• Aero Shadow
  Yes. The Aero Shadow is meaningfully better than a stock Storm Shadow in every performance category. StructuralThe stock Storm Shadow uses a conventional metal airframe at 1,300 kg. The Aero Shadow replaces it with a skeletonized carbon-flex fuselage, cutting …
  datacite lee, francis 2026 置信度 0.66
• “Bright spins and twisted light” Organic Materials for quantum interfaces
  From photosynthesis in a leaf to vision in the retina, the ability of molecules to absorb light and redistribute electronic charge underpins some of life’s most essential processes. In recent decades, chemists and physicists have constructed a parallel world o…
  datacite Chowdhury, Rituparno 2025 置信度 0.66 OptoelectronicsSpin-photon interfaceSpectroscopyMagneto-opticsOrganic Semiconductors
• Information Field Density as a Testable Cross-Scale Organizing Quantity for Chemical and Biological Order
  Living systems are usually explained by separate theories at separate scales: quantum chemistry for bonding and molecular geometry, thermodynamics for energy flow, molecular biology for replication and repair, evolutionary theory for selection, and physiology …
  datacite ARIKAN, FURKAN 2026 置信度 0.66 information field density molecular geometry biological organization origin of life synthetic cells systems biology chirality aging disease biological phase transition
• Engineering sensor-based antithetic integral controllers for enhanced dynamic performance and noise attenuation
  Effective cellular regulation relies on feedback control mechanisms to maintain homeostasis and mitigate environmental fluctuations. We develop and analyze a sensor-based antithetic integral feedback (sAIF) controller that achieves this by embedding proportion…
  datacite Filo, Maurice, Aoki, Stephanie, Hou, Mucun, Anastassov, Stanislav 等 2026 置信度 0.66 genetic circuitsrobust perfect adaptationinteinsintegral feedback controlchemical reaction networks
• A dual Translational framework for addressing food and water contamination in India through the Science–Ayurveda bridge and Italian–Indian Strategic Cooperation
  Description This document presents an innovative dual-tier translational research architecture intended to bridge the gap between contemporary molecular Toxicology and the adaptive Physiopathological frameworks of classical Ayurveda. The framework addresses th…
  datacite Luongo, Valentina 2026 置信度 0.66
• Synthetic Biology and the Creation of Artificial Life: A Comprehensive Umbrella Review and Theoretical Integration [SCIENTIFIC V7.0 - Q1 HIGH-IMPACT]
  Maximum-rigor scientific version 7.0 (Q1 High-Impact) of the Umbrella Review on Synthetic Biology and the Creation of Artificial Life. Optimized for top-tier academic publication (6+ pages) with operationalized models, meta-meta-analytic synthesis, and all 7 P…
  datacite de la Serna, Juan Moises 2026 置信度 0.66 PRISMA 2020Umbrella ReviewQ1 High-ImpactTheoretical Integration
• Synthetic Biology and the Creation of Artificial Life: An Umbrella Review (v7.0)
  High-rigor Scientific Umbrella Review (v7.0) for Synthetic Biology and the Creation of Artificial Life: An Umbrella Review (v7.0)
  datacite de la Serna, Juan Moises 2026 置信度 0.66 NeurobiologyBioethicsFuture TechPRISMA 2020Umbrella Review
• Beyond antitumor activity and from lichenized fungi: advances in the production, bioactivities, synthesis, and biosynthesis of usnic acid and its structural derivatives
  Usnic acid and its structural derivatives are dibenzofuran natural products characterized by a distinctive 6-5-6 tricyclic scaffold. These compounds, isolated from lichenized fungi, non-lichenized fungi, and select higher plants, exhibit a broad spectrum of bi…
  datacite Li, Wei, Liu, Qi, Cui, Can, Yin, Wen-Bing 等 2026 置信度 0.66 BiochemistryMedicineMicrobiologyFOS: Biological sciencesGenetics