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• Integrating the marine carbon resource mannitol into biomanufacturing
  crossref Bo Xin, Cheng Zhong, Yu Wang 2023-01-05T08:51:27Z 置信度 0.70
• Biomanufacturing design: reducing the environmental burden
  crossref Bill Whitford, Daniel Jones, Sean Kinnane 2022-04-17T22:51:33Z 置信度 0.70
• Vision-Based Inspection System for Dimensional Accuracy in Powder-Bed Additive Manufacturing
  Laser powder-bed fusion (L-PBF) is an additive manufacturing (AM) process that enables fabrication of functional metal parts with near-net-shape geometries. The drawback to L-PBF is its lack of dimensional precision and accuracy. The efficiency of powder fusio…
  crossref Masoumeh Aminzadeh, Thomas Kurfess 2016-09-27T13:39:10Z 置信度 0.70
• Molecular Dynamic Simulation of Surface Amorphization of NiTi Under Dynamic Shock Peening
  Surface amorphization of NiTi has been achieved by ultra-high strain rate dynamic loading induced by ultrasonic nano-crystal surface modification (UNSM). The amorphous microstructure was characterized by X-ray diffraction (XRD) and transmission electron micros…
  crossref Zhencheng Ren, Chang Ye, Yalin Dong 2015-09-25T16:32:13Z 置信度 0.70
• Transformation of biomanufacturing by single-use systems and technology
  crossref Gregory T Frank 2018-10-05T14:16:59Z 置信度 0.70
• Digital biomanufacturing supporting vascularization in 3D bioprinting
  Synergies in bioprinting are appearing from individual researchers focusing on divergent aspects of the technology. Many are now evolving from simple mono-dimensional operations to model-controlled multi-material, interpenetrating networks using multi-modal de…
  crossref William Whitford, James B. Hoying 2017-03-21T05:21:53Z 置信度 0.70
• Artificial Intelligence and the Control of Continuous Manufacturing
  crossref Steven S. Kuwahara 2021-12-24T22:18:31Z 置信度 0.70
• Green Simulation Assisted Reinforcement Learning With Model Risk for Biomanufacturing Learning and Control
  crossref Hua Zheng, Wei Xie, M. Ben Feng 2021-03-29T22:03:21Z 置信度 0.70
• Microbial communication during bioremediation of polyaromatic hydrocarbons
  crossref Pooja Sharma 2022-02-18T05:02:42Z 置信度 0.70
• Strategies for Continuous Processing in Microbial Systems
  crossref Julian Kopp, Christoph Slouka, Frank Delvigne, Christoph Herwig 2021-12-24T22:18:31Z 置信度 0.70
• DESCRIPTION WITH FEW DETAILS IN THE PARAMETERS OF THE BIOMANUFACTURING OF BIOPRINTED CONSTRUCTS HARM BEGINNING RESEARCHERS
  crossref M.F. Lima, P.R.S. Brofman, F. Barchiki 2022-10-24T10:55:33Z 置信度 0.70
• Reinforcing Inconel 718 Superalloy by Nano-TiC Particles in Selective Laser Melting
  Metal components produced by additive manufacturing processes usually have inferior properties and performances as compared with the counterparts by the traditional forming and machining processes. To close the gap, the metal matrix can be strengthened by addi…
  crossref Yachao Wang, Jing Shi, Yun Wang 2015-09-25T16:32:13Z 置信度 0.70
• The Future of Talent Science – AI, Complexity, and Autonomous Workforce Systems
  crossref Jason Beckwith 2026-07-06T18:37:49Z 置信度 0.70
• Temperature Simulation and Control System for Automobile Coating Line Drying Rooms
  Product manufacturing systems are one of the largest energy consumers. Focusing on the production of the automobile body coating in particular, the authors investigate the drying system of coating line to improve the energy efficiency during the drying process…
  crossref Zhaoliang Jiang, Wenping Liu, Qingyue Wei, Zhishen Li 2015-09-25T16:32:13Z 置信度 0.70
• 3D printed organoids: From biomanufacturing to medical applications
  The emergence of organoid technology has bridged critical gaps between conventional 2D cell cultures and in vivo systems, offering self-organized 3D microtissues that recapitulate organ-specific architecture, cellular heterogeneity, and functional dynamics. Ho…
  crossref Lingzi Liao, Qiushi Feng, Xiaofeng Xiaofeng, Zhigang Cai 等 2025-06-25T09:47:40Z 置信度 0.70
• Modeling and Characterizing a Novel Hybrid Infill Pattern for Additive Manufacturing
  Abstract In this paper, a novel hybrid infill pattern is introduced denoted as Hexagonal Zigzag pattern and its mechanical properties are investigated through experiments. The novel pattern is island type with zigzag raster repeating in a regular periodic hexa…
  crossref Md Saidur Rahman Roney, AMM Nazmul Ahsan 2023-09-28T21:41:53Z 置信度 0.70
• Special Issue on Biomanufacturing
  The development of medical devices and systems is essential for improving quality of life and reducing global healthcare costs. Machine tools are increasingly used in the medical, automotive, airplane, and electronics fields thanks to advances in manufacturing…
  crossref Naohiko Sugita, Mamoru Mitsuishi 2016-04-14T06:04:52Z 置信度 0.70
• Biomanufacturing of Heterogeneous Hydrogel Structures with Patterned Electrically Conductive Regions
  crossref Ali Nadernezhad, Navid Khani, Bahattin Koc 2017-07-21T11:43:23Z 置信度 0.70
• BioSMB Technology as an Enabler for a Fully Continuous Disposable Biomanufacturing Platform
  crossref Marc Bisschops 2014-12-07T11:18:31Z 置信度 0.70
• Single-use perfusion bioreactors support continuous biomanufacturing
  crossref William (Bill) G Whitford 2015-02-20T13:41:39Z 置信度 0.70
• Processing of biomaterials by additive manufacturing
  crossref Mayurkumar A. Makhesana, Kaushik M. Patel 2023-01-19T20:56:18Z 置信度 0.70
• Industrial Perspective of Industry 5.0
  crossref Apurav Krishna Koyande, Vishno Vardhan Devadas, Kit Wayne Chew, Pau Loke Show 2021-05-08T17:57:53Z 置信度 0.70
• Reducing Warping in ABS 3D Printed Parts Through Infill Modification
  Abstract Additive Manufacturing (AM), or 3D printing, has transformed traditional manufacturing by allowing the layer-by-layer construction of objects from digital models. This study addresses warping in Acrylonitrile Butadiene Styrene (ABS) Fused Filament Fab…
  crossref Weijun Shen, Dharmaraj Veeramani, Hantang Qin 2024-08-20T17:55:25Z 置信度 0.70
• Adaptive Robot Control as a Service in Cloud Manufacturing
  The interest for implementing the concept of Manufacturing-as-a-Service is increasing as concepts for letting the manufacturing shop-floor domain take advantage of the cloud appear. Combining technologies such as Internet of Things, Cloud Computing, Semantic W…
  crossref Göran Adamson, Lihui Wang, Magnus Holm, Philip Moore 2015-09-25T16:32:13Z 置信度 0.70
• Yeast Cell Factory for Production of Biomolecules
  crossref Milky Mittal, Adya Varshney, Nimisha Singh, Ashok Saini 等 2023-01-26T17:03:48Z 置信度 0.70
• The Current State of Sensing, Health Management, and Control for Small-to-Medium-Sized Manufacturers
  The development of digital technologies for manufacturing has been challenged by the difficulty of navigating the breadth of new technologies available to industry. This difficulty is compounded by technologies developed without a good understanding of the cap…
  crossref Moneer Helu, Brian Weiss 2016-09-27T09:39:10Z 置信度 0.70
• On-chip microelectrode impedance analysis of mammalian cell viability during biomanufacturing
  The characterization of cell viability is a challenging task in applied biotechnology, as no clear definition of cell death exists. Cell death is accompanied with a change in the electrical properties of the membrane as well as the cell interior. Therefore, ch…
  crossref Rachita Sharma, Tobias Blackburn, Weiwei Hu, Kelly Wiltberger 等 2014-09-12T00:30:34Z 置信度 0.70
• A Novel Melt Electrospinning System for Studying Cell Substrate Interactions
  Controlling cell behavior has generated immense attention in the fields of tissue engineering and regenerative medicine. Particular emphasis has been given to the creation of 3D biomimetic cellular microenvironments that replicate the complex nature of the ext…
  crossref Filippos Tourlomousis, Azizbek Babakhanov, Houzhu Ding, Robert C. Chang 2015-09-25T16:32:13Z 置信度 0.70
• The Environmental Impacts of Metal Powder Bed Additive Manufacturing
  Abstract Additive manufacturing (AM) is widely recognized as a critical pillar of advanced manufacturing and is moving from the design shop to the factory floor. As AM processes become more popular, it is paramount that engineers and policymakers understand an…
  crossref Jiankan Liao, Daniel R. Cooper 2021-01-15T14:40:52Z 置信度 0.70
• Selective Laser Foaming for Three-Dimensional Cell Culture on a Compact Disc
  A selective laser foaming process is developed to fabricate three-dimensional (3D) scaffold on a commercially available compact disc (CD) made of polycarbonate (PC). The laser-foamed 3D structure could be utilized to form high throughput perfusion-based tissue…
  crossref JinGyu Ock, Wei Li 2015-09-25T16:32:13Z 置信度 0.70
• Modeling of Brittle and Ductile Materials Drilling Using Smoothed-Particle Hydrodynamics
  The objective of this study is to investigate smoothed particle hydrodynamics (SPH) method in simulating drilling process of both brittle and ductile materials. Drilling simulation is commonly performed by finite element method (FEM); however, it is challengin…
  crossref Mahsa Tajdari, Bruce L. Tai 2016-09-27T09:39:10Z 置信度 0.70
• Rethinking Human Capital Metric – From HR Indicators to Talent Science
  crossref Jason Beckwith 2026-07-06T18:37:49Z 置信度 0.70
• Material Processing of PLA-HAp-CS-Based Thermoplastic Composite Through Fused Deposition Modeling for Biomedical Applications
  crossref Nishant Ranjan, Rupinder Singh, IPS Ahuja 2019-03-20T17:40:33Z 置信度 0.70
• Microbial Utilization of Glycerol for Biomanufacturing
  crossref Valeriane Malika Keita, Miriam Gonzalez-Villanueva, Tuck Seng Wong, Kang Lan Tee 2020-07-16T11:02:56Z 置信度 0.70
• Refolding of a Thermostable Glyceraldehyde Dehydrogenase for Application in Synthetic Cascade Biomanufacturing
  crossref Fabian Steffler, Volker Sieber 2013-07-24T23:37:27Z 置信度 0.70
• Energy Assessment Methodology for Mechanical and Electrical Product Assembly Processes
  This paper prescribes an energy assessment methodology, including the procedure and mathematical foundation for evaluating total use and efficiency, for mechanical and electrical product assembly processes. The majority of major manufacturers assemble componen…
  crossref Shaw C. Feng, Senthilkumaran Kumaraguru, Xiufang Sun 2015-09-25T16:32:13Z 置信度 0.70
• Multitrophic rhizosphere-phyllosphere signaling networks regulating plant physiological adaptation and stress resilience.
  Plants operate as metaorganisms, depending on the coordinated signalling between the microbiomes of the roots (rhizosphere) and leaves (phyllosphere). This review covers recent studies that have identified rhizosphere-phyllosphere cross-talk as a crucial deter…
  pubmed Upadhyay SK, Liu S, Kumar Pandey D, Jain D 等 2026 Aug 置信度 0.82
• Molecular Mechanisms of Cellulase Biosynthesis in Trichoderma reesei: Regulatory Networks, Secretion Pathways, and Environmental Modulation.
  Trichoderma reesei (T. reesei), a filamentous fungus, has emerged as a pivotal organism in the realm of cellulase production, garnering significant attention from researchers due to its exceptional cellulolytic properties and the potential for genetic manipula…
  pubmed Cui S, Wei Q, Sadeeq M, Zuo J 等 2026 Jul 置信度 0.82
• Deploying Artificial Metalloenzymes in Complex Environments: Strategies and Applications.
  Artificial metalloenzymes (ArMs) are engineered metalloproteins with modified metal coordination spheres or abiotic metal cofactors, and they are granted the ability to catalyze reactions rarely or never observed in natural biological processes. Due to their c…
  pubmed Yao Y, Su W, Wu T, Bai Y 2026 Jul 14 置信度 0.82
• Synthetic Ligands of Myeloid C-Type Lectin Receptors.
  C-type lectin receptors (CLRs) are one of the major classes of pattern recognition receptors. They mediate numerous biological events, including cell adhesion, pathogen recognition, and innate immune responses. Initial recognition of a pathogen by specific CLR…
  pubmed Suri J, Lepenies B 2026 Jul 14 置信度 0.82
• Beyond The Nucleus: Translating Engineered Protein Localization To Chromatin Modifying Enzymes.
  Chromatin-modifying enzymes (CMEs) have traditionally been studied in their nuclear context for regulating gene expression. However, recent evidence points to the significant non-canonical functions that they perform in the cytoplasm, mitochondria, and plasma …
  pubmed Hirani Z, Tirouvanziam R, Haynes KA 2026 Jun 置信度 0.82
• Embryonic scaling: morphogen gradients, size sensing, and scaler genes.
  Embryonic scaling is the ability of developing embryos to preserve proportional patterning despite differences in overall size. This phenomenon has long been recognized in many animal groups and represents a central example of developmental robustness and self…
  pubmed Timoshina PS, Zaraisky AG 2026 置信度 0.82
• Ameliorated potential and possible mechanisms of medicine food homology for depression.
  Depression is a prevalent neuropsychiatric disorder that poses a significant global health burden. However, current pharmacotherapies are limited by adverse effects and substantial interindividual variability in efficacy. Medicine food homology (MFH), characte…
  pubmed Huo C, Li Q, Cai N, Teng C 等 2026 Jul 置信度 0.82
• Inhibitors of nutrient pathways: nature's overlooked antibiotic arsenal.
  Covering: 1920 to 2026The discovery of antibiotics has historically centered on a core set of physiological targets, including cell wall synthesis, protein translation, and DNA replication. As resistance accelerates and new drug classes remain scarce, there is…
  pubmed Gordzevich R, Jin KY, Ashe JM, Brown ED 2026 Jul 2 置信度 0.82
• Bacterial degradation of aromatic ester pollutants in agro-ecosystems: implications for bioremediation.
  Agricultural fields are increasingly contaminated with aromatic ester compounds originating from insecticides, herbicides, plastic mulching films, adjuvants and stabilizers used in agrochemicals. Many of these esters are persistent and bioaccumulate in the foo…
  pubmed Phale PS, Papade SE, Ghodke VM, Saha BK 等 2026 Jul 1 置信度 0.82
• Towards the construction of a virtual yeast.
  To advance the computational simulation of cellular life, we propose a virtual yeast, an artificial intelligence (AI)-driven agent that models eukaryotic cellular behaviours by integrating multimodal biological data, mechanistic reasoning and active experiment…
  pubmed Qian L, Zhou Z, Zhou P, Dong Z 等 2026 Jul 置信度 0.82
• RNA regulation in plants.
  Eukaryotic genomes are pervasively transcribed, producing a vast repertoire of RNA molecules. In plants, diverse RNA species play pivotal roles in regulating growth, development, and responses to environmental stimuli. The activities of RNAs are determined not…
  pubmed Qi Y, Chen Y, Guo H, Guo H 等 2026 Jun 26 置信度 0.82
• [Development of Protein and RNA Degraders for Drug Discovery].
  Targeted protein degradation (TPD) is an emerging approach that selectively eliminates specific proteins using synthetic molecules, such as proteolysis-targeting chimeras (PROTACs). It has attracted increasing attention in medicinal chemistry and chemical biol…
  pubmed Itoh Y 2026 置信度 0.82
• Advances, challenges, and opportunities in engineering C5 and C6 sugar transporters in yeast for bio-based industrial biotechnology.
  Harnessing biomass for bio-based industrial biotechnology is vital for addressing global energy needs and mitigating climate change. In this context, microorganisms are the cornerstone of biorefineries based on renewable materials, with applications in bioener…
  pubmed Bueno JGR, Fier Í, Kell DB, Santos LVD 2026 Sep 置信度 0.82
• Amylin at the crossroads of type 2 diabetes and neurodegenerative diseases.
  Type 2 diabetes (T2D) is traditionally viewed as a metabolic disease centered on insulin resistance and β-cell failure. However, growing evidence supports its reclassification as a systemic proteinopathy, in which the aggregation of amylin (islet amyloid…
  pubmed López Del Castillo I, Garcia-Martin J, Gutierrez A, Moreno-Gonzalez I 2026 Oct 置信度 0.82
• Recent progress in side-chain amino acid-based polymers: synthesis, self-assembly, and emerging biomedical applications.
  Side-chain amino acid-based polymers (SCAAPs), as a class of functional polymeric materials constructed from natural amino acids or their derivatives, have garnered significant attention in recent years in the fields of materials science and biomedicine. Their…
  pubmed Gao J, Xu S, Niu J, Chen A 等 2026 Jul 22 置信度 0.82
• Advances in the HAK/KUP/KT Potassium Transporter Family in Regulating Na+/K+ Homeostasis and Salt Tolerance in Plants.
  Soil salinization severely threatens global agricultural sustainability. A key physiological mechanism underpinning plant salt tolerance is the maintenance of Na+/K+ homeostasis. The HAK/KUP/KT family of high-affinity potassium transporters plays a central rol…
  pubmed Wu L, Ma J, Zhang Y, Zhang X 等 2026 Jul 1 置信度 0.82
• Harnessing the power of date fruit: nutritional, bioactive, and functional roles in sustainable nutrition.
  Date fruit is a nutrient-dense and bioactive-rich fruit that has garnered attention for its dual role in athletic performance and sustainable nutrition. Naturally abundant in readily digestible carbohydrates, dietary fiber, essential minerals, vitamins, and po…
  pubmed Khedr EH, Alomran MM 2026 Jul 1 置信度 0.82
• Drugs and products in beekeeping: Efficacy and perspectives of natural alternatives.
  Honeybee health is a key factor in sustainable apiculture, with the most significant colony losses attributed to the mite Varroa destructor and microsporidia of the genus Nosema spp. The aim of this review article is to …
  pubmed Szabo I, Sabova L, Sabo R, Sucik M 2026 May 置信度 0.82
• Next-generation fermented foods: engineering the future of functional nutrition and emerging food safety challenges.
  Fermented foods have long been recognized for their significant contributions to human health, particularly in enhancing gastrointestinal functionality, increasing microbial diversity, and improving nutrient bioavailability. In recent years, the intersection o…
  pubmed Hacıfettahoğlu BN, Bilici S 2026 置信度 0.82
• Lineage tracing from cellular heritage to disease destiny.
  The developmental history of a cell fundamentally defines its identity and function. Recent advances in cell lineage tracing now enable high-resolution reconstruction of cellular ancestries in vivo, illuminating how lineage dictates fate in health and disease.…
  pubmed Zhu H, Liu X, Tang M, Lui KO 等 2026 Jul 置信度 0.82
• Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.
  The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolving rapidly from the successful application of chimeric antigen receptor T (CAR-T) cells in hematologic malign…
  pubmed Zi G, Zhang L, Zhou L, Liu X 等 2026 Jul 1 置信度 0.82
• Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.
  Disruptions in cellular energy metabolism have emerged as central contributors to a broad spectrum of human diseases. While conventional therapeutic strategies can alleviate symptoms, they typically target downstream disease manifestations and often fail to ad…
  pubmed Li Y, Gao Y, Song D, Liu Y 等 2026 Aug 置信度 0.82
• Hydrogel-based strategies for dentin-pulp complex regeneration: a comprehensive review.
  The clinical management of dental caries encompasses a spectrum of therapeutic approaches, ranging from conservative restorative procedures to complex endodontic interventions. In cases involving pulp exposure or reversible pulpal injury, vital pulp therapy pr…
  pubmed Amani R, Rafiee M, Karatas E, Hasanzade S 等 2026 Jun 30 置信度 0.82
• Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress.
  Dry eye disease (DED) is a prevalent, age-related ocular disorder that severely impairs vision and quality of life. Age-related cellular senescence drives disease progression through the senescence-associated secretory phenotype (SASP), which establishes a sel…
  pubmed Ren Q, Zhu X, Zhai Y, Rong G 等 2026 Nov 置信度 0.82
• Terpene synthases screening in agarwood tree Aquilaria yunnanensis leads to the discovery of agarospirol.
  Agarwood, renowned as one of the most valuable natural materials in the world of fragrance, is notoriously difficult and time-consuming to obtain, creating a critical bottleneck for its utilization and conservation. Sesquiterpenes are the key constituents of a…
  pubmed Wen S, Cheng W, Li Y, Er L 等 2027 Jan 置信度 0.82
• Decoding the reproductive microbiome: enabling clinical and biological insights through machine and deep learning.
  Technological advances have revolutionised the microbiome research in the field of human reproduction, identifying the microbiome as important regulator of reproductive health and functions, where microbes are now linked to sperm quality, ovarian function, end…
  pubmed Garach Vélez I, Leonés-Baños I, Folch BA, Antequera L 等 2026 置信度 0.82
• Oligonucleotides Post-Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid-Phase Synthesis.
  Chemical modification of oligonucleotides has become an essential strategy to improve their properties and expand their functional utility in chemical biology, molecular imaging, and therapeutics. Among the various modification strategies, post-synthetic bioor…
  pubmed Depienne S, Bristiel A, Urban D, Guianvarc'h D 2026 Jul 14 置信度 0.82
• Diverse molecular mechanisms of in vivo haploid induction in plants: from fertilization interference to genome programming.
  In vivo haploid induction has revolutionized crop breeding by shifting it from experience-driven selection to precision design methodologies. This review synthesizes three core mechanistic modules-male gamete defects (MTL/DMP/KPL), gametophyte reprogramming (B…
  pubmed Wu W, Ding Y, Guan Y, Luo Z 等 2026 Jun 29 置信度 0.82
• [Skin organoids: an emerging platform from three-dimensional construction to regenerative application].
  Skin organoids are three-dimensional, self-organized in vitro models that recapitulate the architecture and function of skin tissue. This article comprehensively outlines the current progress and application prospects of skin organoids. Based on complexity, sk…
  pubmed Leng L, Xiao SC 2026 Jun 20 置信度 0.82
• Computationally guided strategies to modulate enzyme pH profiles for industrial biocatalysis and environmental applications.
  Enzymes are indispensable biocatalysts; however, their industrial and environmental applications are often constrained due to their narrow pH ranges. This review provides a comprehensive overview of computational-guided strategies for rationally engineering en…
  pubmed Ahmad M, Iqbal MW, Mirza MU, Raza MA 等 2026 Sep 置信度 0.82
• To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis.
  Biotic-abiotic interfaced configurations hold great promise for application in renewable energy and artificial photosynthesis systems. Recent advances in synthetic biology, computational, and visualization techniques, along with enhanced high-resolution charac…
  pubmed Cohen Y, Bachar O, Cohen R, Meirovich MM 等 2026 Jul 22 置信度 0.82
• Gnotobiology: from 19th-century global foundations to 21st-century omics - six decades of Czech contribution to microbiome research.
  Gnotobiology, from the Greek gnotos (meaning 'known') and bios (meaning 'life'), is a research discipline that uses organisms with a defined microbiological status to study the interaction between hosts and microbes. This review traces six decades of Czech gno…
  pubmed Tlaskalová-Hogenová H, Hrnčíř T, Štěpánková R, Trebichavský I 等 2026 Jun 29 置信度 0.82
• SuFEx chemistry for nucleosides, nucleotides, and nucleic acids.
  Sulfur(vi) fluoride exchange (SuFEx) reactions were introduced as next-generation click transformations that form robust sulfur(vi)-based linkages under mild conditions. Their defining feature is the unusual behaviour of the S-F bond: it is thermodynamically s…
  pubmed Chromiński M, Żmudziński M, Jemielity J 2026 Aug 5 置信度 0.82
• The structural chemistry and biosynthesis of chlorophylls.
  Chlorophylls (Chls) harvest the solar energy that drives photosynthesis, which underpins most of the food chains on our planet. Starting from protoporphyrin IX, just seven biosynthetic reactions culminate in the synthesis of Chl a , the major light-absorbing p…
  pubmed Hunter CN, Morey-Burrows FS 2026 Jul 8 置信度 0.82
• Microbial-Based Agrochemicals: Cell-in and Cell-free Formulations, Application, and Production via Agricultural Byproducts for a Circular Economy.
  Modern agriculture relies on synthetic agrochemicals, but regulatory pressure, environmental costs, and supply chain volatility are accelerating interest in microbial-based agrochemicals (MBAs) as renewable inputs for sustainable intensification. This review f…
  pubmed Buttrós VH, Resende de Souza Castro C, D'Ávilla VA, Ribeiro NAS 等 2026 Jun 23 置信度 0.82
• Engineered diazotrophs with host-inducible nitrogen supply systems: Transforming rice farming through innovative nitrogen biofertilizers.
  Nitrogen pollution represents a critical challenge in the 21st century, highlighting the urgent need for sustainable alternatives to industrial nitrogen fixation. Diazotrophic bacteria, which uniquely convert dinitrogen (N 2 ) into bioavailable forms, offer a …
  pubmed Sengupta A, Sahoo RN, Sinharoy S 2026 Aug 置信度 0.82
• Engineered bacterial biofilms for biotechnological applications.
  Bacterial systems are emerging as living technologies for sustainable manufacturing, environmental monitoring, agriculture, and health. They form biofilms, that is, living materials, which can be repurposed in biological applications due to their properties, f…
  pubmed Hashemi N, Osiro KO, Franco OL, Oliveira SMD 2026 Jun 26 置信度 0.82
• Catalytic valorization of polyolefins: from catalysts and processes to reactors.
  Polyolefins account for more than half of global plastic production. However, their short service life and limited recyclability have led to severe environmental pollution and substantial resource loss. Catalytic valorization has emerged as a promising strateg…
  pubmed Wu C, Guo C, Xu X, Liu K 等 2026 Jul 20 置信度 0.82
• Toward Precision Bioconjugation: Chemical Strategies for Site-Selective Cysteine Conjugation.
  The ability to access atomically tailored complex peptides and proteins provides powerful opportunities for dissecting molecular functions and advancing applications in chemical biology, therapeutics, and (bio)-materials science. Robust precision-engineering s…
  pubmed Gavriel K, Neumann K 2026 Jun 22 置信度 0.82
• Engineering Strategies for Plant-Derived Extracellular Vesicles: Modification, Drug Delivery Performance, and Synergistic Effects with Gel Composite Systems.
  Plant-derived extracellular vesicles (PDEVs) are a novel category of natural nanocarriers with widespread availability, low immunogenicity, high biocompatibility, and inherent pharmacological activity. These features underscore their value as dual-function sys…
  pubmed Qiu X, Wusiman Y, Yusufujiang N, Dilimulati D 等 2026 May 27 置信度 0.82
• Targeting the Human Gut Microbiota-Between Conventional Therapy and Precision Genetic Engineering.
  The gut microbiota is increasingly examined as a therapeutic target because it contributes to epithelial barrier integrity, microbial metabolite production, bile acid transformation, immune regulation, and communication between the gut and distant organs. This…
  pubmed Ciurea NA, Mahdi L, Graziani A, Di Ciaula A 等 2026 Jun 17 置信度 0.82
• Therapeutic Applications of Natural Products in Biomedicine and Pharmacotherapy.
  Natural products are the fundamentals of drug discovery due to their exceptional structural diversity and biological activity's evolutionary optimization. The review provides a critical and integrative analysis of natural products in pharmaceutical chemistry, …
  pubmed Sah AK, Patel S, Kumar R, Mishra PS 等 2026 May 22 置信度 0.82
• Engineering Plant-Associated Microorganisms for Bioremediation and Sustainable Agriculture.
  As food demand increases, agricultural practices have evolved, prompting increased exploration of sustainable ecological techniques and utilization of plant-associated microorganisms. In this context, plant fitness has been enhanced by plant growth-promoting m…
  pubmed Flores AI, Morales-Cedeño LR, Loeza-Lara PD, Schoebitz M 等 2026 May 26 置信度 0.82
• From Discovery to Manufacturing: A Quantitative Review of Phosphonates and Strategies for High-Titer Production.
  Phosphonate natural products, characterized by a stable carbon-phosphorus (C-P) bond, represent a distinctive class of natural products with broad bioactivities and diverse applications in medicine and agriculture. Despite their potential, the field has lacked…
  pubmed Zhong X, Song B, Zhang L, Hsiang T 等 2026 May 22 置信度 0.82
• Generative AI and Language Models in Human Genetics and Health: From Variant Interpretation to Clinical Decision Support.
  Generative artificial intelligence (AI) is transforming biological and medical research and data analysis. Beyond analyzing existing information, these models can learn complex patterns and generate new data such as realistic protein sequences, genetic variant…
  pubmed Pinchevsky Itan Y, Itan Y 2026 Jun 22 置信度 0.82
• From Genome to Pharmacome: Current Status and Future Perspectives of Multi-Omics Integration in Traditional Chinese Medicine Research.
  High-throughput sequencing and multi-omics are transforming Traditional Chinese Medicine (TCM) research from empirical descriptions toward data-driven mechanistic analyses. Unlike earlier systems pharmacology frameworks that relied primarily on static network …
  pubmed Yu T, Chen C, Hu P, Zou Y 等 2026 May 30 置信度 0.82
• Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression.
  Cyanobacteria are increasingly recognised as photosynthetic chassis for sustainable metabolic engineering because oxygenic photosynthesis generates ATP and NADPH via the photosynthetic electron transport chain, which drive CO 2 fixation through the Calvin-Bens…
  pubmed Walshe J, Saha SK 2026 Jun 19 置信度 0.82
• Microbial α-L-Rhamnosidases: Regioselective Biocatalysts for Flavonoid Biotransformation and Nutraceutical Applications.
  Microbial α-L-rhamnosidases are increasingly recognised as selective biocatalysts in food biotechnology, nutraceutical production, and health-related applications. These glycoside hydrolases catalyse the hydrolysis of terminal alpha-L-rhamnose residues f…
  pubmed Iorizzo M 2026 Jun 16 置信度 0.82
• Metabolic Pathways and Molecular Regulatory Mechanisms of Nervonic Acid Biosynthesis in Malania oleifera.
  Nervonic acid (NA, C24:1 Δ15) is a vital extra-long-chain monounsaturated fatty acid essential for neural development, myelin sheath formation, and neurological health. As the most abundant natural source of NA, Malania oleifera Chun & S.K.Lee has be…
  pubmed Xu Q, Jiang C, Dong M, Liao L 等 2026 Jun 18 置信度 0.82
• Targeting p53 in Cancer: Functional States, Therapeutic Strategies, and Clinical Progress.
  TP53 is the most frequently altered tumor-suppressor gene in human cancer, yet efforts to therapeutically target p53 have yielded limited and inconsistent clinical success. We argue that this gap reflects not a lack of druggable biology, but an oversimplified …
  pubmed Saunders A, Barkin J, Karnezis A, Chien J 2026 Jun 6 置信度 0.82
• In Vivo mRNA-Lipid Nanoparticle CAR-T Cell Engineering: Advances, Challenges, and Clinical Translation.
  Chimeric antigen receptor T (CAR-T) cell therapy has transformed the treatment of hematologic malignancies, yet its broader application, particularly in solid tumors, remains constrained by high cost, labor-intensive manufacturing, limited production capacity,…
  pubmed Yadav VK, Yadav P, Mallappa S, Neeli P 2026 Jun 3 置信度 0.82
• Multiscale and programmable engineering of edible mushroom mycelium-based materials.
  Edible mushroom mycelium-based materials are emerging as renewable, route-dependent systems spanning composites, flexible sheets, hydrogels, aerogels, and hybrid materials, rather than a single engineering class. In this review, we synthesize how strain select…
  pubmed Kong X, Xiao S, Yu H, Li Y 等 2026 Jun 25 置信度 0.82
• Progress in engineered bacterial cancer therapies.
  Engineered bacteria are emerging as powerful tools in the development of cancer therapies, driven by advances in synthetic biology and tumor immunology. These microbes preferentially colonize solid tumors, where they can deliver therapeutic agents directly to …
  pubmed Pico-Sánchez E, Fernández LÁ 2026 Aug 置信度 0.82
• Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.
  The cell plasma membrane of eukaryotic cells is a fantastically complex and important system ensuring the transport of information from the environment towards individual cells and vice versa. It provides a mechanical and chemical delimitation of the cell, ena…
  pubmed Köster DV 2026 Aug 置信度 0.82
• AI-driven cellular immunotherapy: transforming CAR-T engineering and translation.
  Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated remarkable success in hematologic malignancies but faces persistent challenges in solid tumors and broader clinical translation, including limited target specificity, heterogeneous tumor antigen…
  pubmed Huang Z, Wang X, Lin L, Liu Y 等 2026 Sep 置信度 0.82
• Engineering growth independent production: programmable control loops for high-titer rhamnolipids for improved green surfactant sustainability.
  Rhamnolipid biosurfactants have garnered significant attention as renewable, biodegradable alternatives to conventional, petroleum-derived surfactants, aligning closely with global sustainable development goals. Nevertheless, their commercial viability remains…
  pubmed Gaur VK, Shweta, Raheja Y, Ainala SK 等 2026 Aug 置信度 0.82
• Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.
  Over the past few decades, antibacterial discovery has changed substantially, yet innovation has remained slow despite the growing need for new agents active against multidrug-resistant pathogens. Progress is constrained by scientific hurdles, including target…
  pubmed Fernandes GFS, Kim SH, Dos Santos JL, Wang Y 等 2026 Jul 20 置信度 0.82
• Bacterial Outer Membrane Vesicles: Research Advances from Biogenesis Mechanisms to Engineered Applications.
  Bacterial outer membrane vesicles (OMVs) are spherical structures made up of a double layer, they are each nanostructured (20-300 nm), and they are released from all populations of Gram-negative bacteria. The purpose of this review is to synthesize a comprehen…
  pubmed Zhang M, Zhao X, Tang M, Zou W 2026 Jun 11 置信度 0.82
• The Gut Microbiome Dependency Continuum in Drug Discovery: A Unified Pharmacology Framework Linking Clinical Drugs, Natural Products, and Engineered Microbial Therapeutics.
  Highlighting its pivotal role in modern pharmacology, the gut microbiome is emerging as a key determinant of drug efficacy, toxicity, and bioavailability. This review proposes the Gut Microbiome Dependency Continuum, a four-layer framework describing progressi…
  pubmed Habtemariam S 2026 Jun 10 置信度 0.82
• From Plant Metabolites to Pollinator Safety: Rethinking Selectivity of Botanical Insecticides in Bees-A Review.
  Botanical insecticides have re-emerged as promising tools within Integrated Pest Management (IPM) due to their biodegradability, chemical diversity, and potential compatibility with resistance management strategies. Although frequently considered safer alterna…
  pubmed Souza SA, Padial IMPM, Conceição da Cruz JV, Camargo MG 等 2026 Jun 17 置信度 0.82
• Microbial Ecology at the Nexus of Food Safety and Biotechnology With Ecological Mechanisms, Risks, and Emerging Innovations.
  Food systems are complex microbial ecosystems in which microorganisms play dual and often contrasting roles as agents of foodborne contamination and as essential drivers of food production and biotechnological innovation. Microbial ecology provides an integrat…
  pubmed Tepson JA, Agyirifo DS 2026 置信度 0.82
• Codon compression and novel codon creation for multiplex non-canonical amino acid incorporation.
  Genetic code expansion (GCE) provides a robust platform for engineering protein function via the site-specific incorporation of noncanonical amino acids (ncAAs). While traditional methods are primarily limited to single site incorporation, the growing demand f…
  pubmed Li Y, Ma X, Huo YX 2026 Oct 置信度 0.82
• Targeting strategies of lipid nanoparticles for RNA therapeutics: From hepatic tropism to extrahepatic precision delivery.
  Lipid nanoparticles (LNPs) have revolutionized nucleic acid therapeutics, yet their inherent ApoE-mediated liver tropism remains a formidable barrier to extrahepatic applications. This review critically synthesizes emerging breakthroughs in engineering next-ge…
  pubmed Zhu X, Sun H, Cao X, Xia J 2026 Jun 24 置信度 0.82
• Toward aitiopoietic cognition: bridging the evolutionary divide between biological and machine-learned causal systems.
  We examine and compare autopoietic systems (biological organisms) and machine learning systems (MLSs) highlighting crucial differences in how causal reasoning emerges and operates. Despite superficial functional similarities in behavior and cognitive abilities…
  pubmed Veloz T 2025 置信度 0.82