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• Rewiring carbon catabolite repression for microbial cell factory
  Carbon catabolite repression (CCR) is a key regulatory system found in most microorganisms that ensures preferential utilization of energy-efficient carbon sources. CCR helps microorganisms obtain a proper balance between their metabolic capacity and the maxim…
  openalex Vinuselvi Parisutham, Min Kyung Kim, Sung-Kuk Lee, Cheol-Min Ghim 2012-02-29 置信度 0.72 Catabolite repressionFed-batch culturePsychological repressionChemistryFactory (object-oriented programming)
• Strategies and Challenges for the Development of Industrial Enzymes Using Fungal Cell Factories
  openalex José Arnau, Debbie Yaver, Carsten Hjort 2020-01-01 置信度 0.72 Trichoderma reeseiIndustrial biotechnologyBiochemical engineeringAspergillus nigerBiotechnology
• A systems-level approach for metabolic engineering of yeast cell factories
  The generation of novel yeast cell factories for production of high-value industrial biotechnological products relies on three metabolic engineering principles: design, construction, and analysis. In the last two decades, strong efforts have been put on develo…
  openalex Il‐Kwon Kim, António Roldão, Verena Siewers, Jens Nielsen 2011-12-22 置信度 0.72 Synthetic biologyMetabolic engineeringSystems biologyIdentification (biology)Biology
• Rhodococcus aetherivorans BCP1 as cell factory for the production of intracellular tellurium nanorods under aerobic conditions
  Tellurite (TeO3 2−) is recognized as a toxic oxyanion to living organisms. However, mainly anaerobic or facultative-anaerobic microorganisms are able to tolerate and convert TeO3 2− into the less toxic and available form of elemental Tellurium (Te0), producing…
  openalex Alessandro Presentato, Elena Piacenza, Max Anikovskiy, Martina Cappelletti 等 2016-12-01 置信度 0.72 ChemistryAnaerobic exerciseNanorodNanomaterialsFood science
• Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production
  Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extracted from plants. A resource-conserving and enviro…
  openalex Xiaonan Liu, Wentao Ding, Huifeng Jiang 2017-07-19 置信度 0.72 Industrial microbiologyMetabolic engineeringIndustrial biotechnologyBiochemical engineeringBiotechnology
• Yeast cell factories for fine chemical and API production
  This review gives an overview of different yeast strains and enzyme classes involved in yeast whole-cell biotransformations. A focus was put on the synthesis of compounds for fine chemical and API (= active pharmaceutical ingredient) production employing singl…
  openalex Beate Pscheidt, Anton Glieder 2008-01-01 置信度 0.72 YeastYarrowiaGeotrichumTrichosporonRhodotorula
• Large-scale generation of mature monocyte-derived dendritic cells for clinical application in cell factories™
  openalex Thomas Berger, Bernadette Feuerstein, Erwin Strasser, Ute Hirsch 等 2002-09-10 置信度 0.72 ApheresisPeripheral blood mononuclear cellLeukapheresisDendritic cellImmunotherapy
• CRISPR/Cas9‐mediated genome engineering of CHO cell factories: Application and perspectives
  Chinese hamster ovary (CHO) cells are the most widely used production host for therapeutic proteins. With the recent emergence of CHO genome sequences, CHO cell line engineering has taken on a new aspect through targeted genome editing. The bacterial clustered…
  openalex Jae Seong Lee, Lise Marie Grav, Nathan E. Lewis, Helene Faustrup Kildegaard 2015-06-09 置信度 0.72 CRISPRGenome editingCas9Genome engineeringGenome
• Cell factories converting lactate and acetate to butyrate: Clostridium butyricum and microbial communities from dark fermentation bioreactors
  BACKGROUND: Interactions between microorganisms during specific steps of anaerobic digestion determine metabolic pathways in bioreactors and consequently the efficiency of fermentation processes. This study focuses on conversion of lactate and acetate to butyr…
  openalex Anna Detman, Damian Mielecki, Aleksandra Chojnacka, Agnieszka Salamon 等 2019-02-13 置信度 0.72 Clostridium butyricumFermentationButyrateBioreactorClostridium
• Plant Aromatic Prenyltransferases: Tools for Microbial Cell Factories
  openalex Wouter J.C. de Bruijn, Mark Levisson, Jules Beekwilder, Willem J. H. van Berkel 等 2020-04-13 置信度 0.72 Aromatic plantsChemistryBiotechnologyBiochemical engineeringComputational biology
• Transporter engineering in microbial cell factories: the ins, the outs, and the in-betweens
  Engineering the transport of small molecules is an effective approach to improve the performance of microbial cell factories. Transporter engineering can improve the utilization of low-cost alternative substrates, reduce the loss of pathway intermediates, and …
  openalex Steven A. van der Hoek, Irina Borodina 2020-09-11 置信度 0.72 TransporterIdentification (biology)Biochemical engineeringSynthetic biologyComputational biology
• Recombinant production of eukaryotic cytochrome P450s in microbial cell factories
  Cytochrome P450s (P450s) comprise one of the largest known protein families. They occur in every kingdom of life and catalyze essential reactions, such as carbon source assimilation, synthesis of hormones and secondary metabolites, or degradation of xenobiotic…
  openalex Johanna Hausjell, Heidi Halbwirth, Oliver Spadiut 2018-02-08 置信度 0.72 Pichia pastorisSaccharomyces cerevisiaeBiochemistryRecombinant DNAEscherichia coli
• Identification of potentially safe promising fungal cell factories for the production of polyketide natural food colorants using chemotaxonomic rationale
  BACKGROUND: Colorants derived from natural sources look set to overtake synthetic colorants in market value as manufacturers continue to meet the rising demand for clean label ingredients - particularly in food applications. Many ascomycetous fungi naturally s…
  openalex Sameer A. S. Mapari, Anne S. Meyer, Ulf Thrane, Jens C. Frisvad 2009-04-27 置信度 0.72 BiologyMycotoxinPenicilliumMonascusCitrinin
• Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger
  BACKGROUND: Filamentous fungi such as Aspergillus niger have a high capacity secretory system and are therefore widely exploited for the industrial production of native and heterologous proteins. However, in most cases the yields of non-fungal proteins are sig…
  openalex Thomas Guillemette, Noël N. M. E. van Peij, T. Goosen, Karin Lanthaler 等 2007-06-11 置信度 0.72 Unfolded protein responseBiologySecretory proteinEndoplasmic reticulumSecretion
• Algal omics: unlocking bioproduct diversity in algae cell factories
  openalex Michael T. Guarnieri, Philip T. Pienkos 2014-03-13 置信度 0.72 AlgaePlant physiologyBiologyOmicsComputational biology
• New Transposon Tools Tailored for Metabolic Engineering of Gram-Negative Microbial Cell Factories
  Re-programming microorganisms to modify their existing functions and/or to bestow bacteria with entirely new-to-Nature tasks have largely relied so far on specialized molecular biology tools. Such endeavors are not only relevant in the burgeoning metabolic eng…
  openalex Esteban Martínez-García, Tomás Aparicio, Víctor de Lorenzo, Pablo I. Nikel 2014-10-28 置信度 0.72 Pseudomonas putidaBiologyTransposon mutagenesisMutagenesisSynthetic biology
• Developing Bacillus spp. as a cell factory for production of microbial enzymes and industrially important biochemicals in the context of systems and synthetic biology
  openalex Long Liu, Yanfeng Liu, Hyun‐Dong Shin, Rachel R. Chen 等 2013-06-10 置信度 0.72 Context (archaeology)Synthetic biologyBiotechnologyBiochemical engineeringMetabolic engineering
• Beyond the cell factory: Homeostatic regulation of and by the UPR ^ER
  The UPR ER is generally considered a protein homeostasis machinery, but this review uncovers many additional functions of UPR ER .
  openalex Melissa G. Metcalf, Ryo Higuchi‐Sanabria, Gilberto Garcia, C. Kimberly Tsui 等 2020-07-15 置信度 0.72 HomeostasisFactory (object-oriented programming)Cell biologyBiologyChemistry
• Nanotechnology, bionanotechnology and microbial cell factories
  Nanotechnology is increasingly using both materials and nano-objects synthesized by living beings, most of them produced by microbial cells. Emerging technologies and highly integrative approaches (such as 'omics and systems biology), that have been largely pr…
  openalex Antonio Villaverde 2010-01-01 置信度 0.72 NanobiotechnologyNanomedicineNanotechnologyContext (archaeology)Biochemical engineering
• MicroRNAs as targets for engineering of CHO cell factories
  openalex Dethardt Müller, Hermann Katinger, Johannes Grillari 2008-05-29 置信度 0.72 Chinese hamster ovary cellmicroRNABiopharmaceuticalBiologyComputational biology
• Systems metabolic engineering, industrial biotechnology and microbial cell factories
  Publikationsserver. Lee, Sang Yup; Mattanovich, Diethard; Villaverde, Antonio: Systems metabolic engineering, industrial biotechnology and microbial cell factories. In: Microbial Cell Factories. BioMed Central (BMC), 2012
  openalex Sang Yup Lee, Diethard Mattanovich, Antonio Villaverde 2012-12-01 置信度 0.72 Metabolic engineeringIndustrial microbiologyBiotechnologySynthetic biologyBiology
• Yeast cell factories on the horizon
  Metabolic engineering in yeast gets increasingly more versatile [Also see Report by Galanie et al. ]
  openalex Jens Nielsen 2015-09-03 置信度 0.72 YeastHorizonBiologyChemistryMathematics
• Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories Improvement
  Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast Yarrowia lipolytica appears as one of the most attractive for a large range of white biotechnology applications, from heterologous proteins secretion to cell factories process…
  openalex Catherine Madzak 2021-07-10 置信度 0.72 YarrowiaBiologyYeastBiotechnologyMetabolic engineering
• Towards the development of Bacillus subtilis as a cell factory for membrane proteins and protein complexes
  BACKGROUND: The Gram-positive bacterium Bacillus subtilis is an important producer of high quality industrial enzymes and a few eukaryotic proteins. Most of these proteins are secreted into the growth medium, but successful examples of cytoplasmic protein prod…
  openalex Jessica C. Zweers, Imrich Barák, Dörte Becher, Arnold J. M. Driessen 等 2008-04-04 置信度 0.72 Bacillus subtilisMembrane proteinProtein qualityProtein biosynthesisBiology
• Yarrowia lipolytica as an Oleaginous Cell Factory Platform for Production of Fatty Acid-Based Biofuel and Bioproducts
  Today’s biotechnologists seek new biocatalysts to meet the growing demand for the bioproducts. This review critically evaluates the potential use of Y. lipolytica as an oleaginous cell factory platform. This yeast has undergone extensive modifications for conv…
  openalex Ali Abghari, Shulin Chen 2014-06-19 置信度 0.72 YarrowiaBioproductsBiofuelBiodieselBiomass (ecology)
• The Neutrino Factory and Beta Beam Experiments and Development
  The long-term prospects for fully exploring three-flavor mixing in the neutrino sector depend upon an ongoing and increased investment in the appropriate accelerator R&D. Two new concepts have been proposed that would revolutionize neutrino experiments, na…
  arxiv C. Albright, V. Barger, J. Beacom, S. Brice 等 2004-11-12T20:02:19Z 置信度 0.78 physics.acc-phhep-ph
• Modeling adult skeletal stem cell response to laser-machined topographies through deep learning
  The response of adult human bone marrow stromal stem cells to surface topographies generated through femtosecond laser machining can be predicted by a deep neural network. The network is capable of predicting cell response to a statistically significant level,…
  arxiv Benita S. Mackay, Matthew Praeger, James A. Grant-Jacob, Janos Kanczler 等 2020-05-30T12:21:17Z 置信度 0.78 eess.IVcs.LG
• Non-genetic heterogeneity criticality and cell differentiation
  The different cell types in a living organism acquire their identity through the process of cell differentiation in which the multipotent progenitor cells differentiate into distinct cell types. Experimental evidence and analysis of large-scale microarray data…
  arxiv Mainak Pal, Sayantari Ghosh, Indrani Bose 2014-05-06T09:37:02Z 置信度 0.78 q-bio.CBq-bio.MN
• Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
  Regulation of cell proliferation is a crucial aspect of tissue development and homeostasis and plays a major role in morphogenesis, wound healing, and tumor invasion. A phenomenon of such regulation is contact inhibition, which describes the dramatic slowing o…
  arxiv Steffen Lange, Jannik Schmied, Paul Willam, Anja Voss-Böhme 2024-03-12T12:49:47Z 置信度 0.78 q-bio.CBnlin.CGphysics.bio-phphysics.data-anq-bio.TO
• Cell types and ontologies of the Human Cell Atlas
  Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body, while at the same time raising the need to formalise this new knowledge. Here, we review current cell ontology efforts to harmonise and integrat…
  arxiv David Osumi-Sutherland, Chuan Xu, Maria Keays, Peter V. Kharchenko 等 2021-06-28T07:54:37Z 置信度 0.78 q-bio.CB
• Mechanism for collective cell alignment in Myxococcus xanthus bacteria
  Myxococcus xanthus cells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, the mechanism underlying the cell ali…
  arxiv Rajesh Balagam, Oleg A. Igoshin 2015-06-01T21:32:47Z 置信度 0.78 physics.bio-phq-bio.CB
• A Search for New Candidate Super-Chandrasekhar-Mass Type Ia Supernovae in the Nearby Supernova Factory Dataset
  We present optical photometry and spectroscopy of five type Ia supernovae discovered by the Nearby Supernova Factory selected to be spectroscopic analogues of the candidate super-Chandrasekhar-mass events SN 2003fg and SN 2007if. Their spectra are characterize…
  arxiv The Nearby Supernova Factory, :, R. Scalzo, G. Aldering 等 2012-07-11T16:19:46Z 置信度 0.78 astro-ph.CO
• How negative feedback from filamentous actin affects cell shapes and motility
  The crawling motility of many eukaryotic cells is driven by filamentous actin (F-actin), and regulated by a network of signaling proteins and lipids (including small GTPases). The tangle of positive and negative feedback loops gives rise to various experimenta…
  arxiv Jack M. Hughes, Jupiter Algorta, Leah Edelstein-Keshet 2026-02-09T15:22:14Z 置信度 0.78 q-bio.CB
• The Gamma Factory proposal for CERN
  This year, 2015, marks the centenary of the publication of Einsteins Theory of General Relativity and it has been named the International Year of Light and light-based technologies by the UN General Assembly. It is thus timely to discuss the possibility of bro…
  arxiv Mieczyslaw Witold Krasny 2015-11-24T16:41:45Z 置信度 0.78 hep-exhep-phphysics.acc-ph
• Physics Opportunities at mu+mu- Higgs Factories
  We update theoretical studies of the physics opportunities presented by mu+mu- Higgs factories. Interesting measurements of the Standard Model Higgs decays into {\bar b}b, tau+tau- and WW* may be possible if the Higgs mass is less than about 160 GeV, as prefer…
  arxiv C. Blöchinger, M. Carena, J. Ellis, H. Fraas 等 2002-02-21T14:47:33Z 置信度 0.78 hep-ph
• CellPhoneDB v5: inferring cell-cell communication from single-cell multiomics data
  Cell-cell communication is essential for tissue development, regeneration and function, and its disruption can lead to diseases and developmental abnormalities. The revolution of single-cell genomics technologies offers unprecedented insights into cellular ide…
  arxiv Kevin Troulé, Robert Petryszak, Martin Prete, James Cranley 等 2023-11-08T09:59:03Z 置信度 0.78 q-bio.CBq-bio.QM
• A Critical-like Collective State Leads to Long-range Cell Communication in Dictyostelium discoideum Aggregation
  The transition from single-cell to multicellular behavior is important in early development but rarely studied. The starvation-induced aggregation of the social amoeba Dictyostelium discoideum into a multicellular slug is known to result from single-cell chemo…
  arxiv Giovanna De Palo, Darvin Yi, Robert G. Endres 2018-01-11T10:59:35Z 置信度 0.78 q-bio.CBq-bio.PE
• A 5G Architecture for The Factory of the Future
  Factory automation and production are currently undergoing massive changes, and 5G is considered being a key enabler. In this paper, we state uses cases for using 5G in the factory of the future, which are motivated by actual needs of the industry partners of …
  arxiv Stephan Ludwig, Michael Karrenbauer, Amina Fellan, Hans D. Schotten 等 2018-09-25T10:20:01Z 置信度 0.78 cs.NI
• Simultaneous regulation of cell size and chromosome replication in bacteria
  Bacteria are able to maintain a narrow distribution of cell sizes by regulating the timing of cell divisions. In rich nutrient conditions, cells divide much faster than their chromosomes replicate. This implies that cells maintain multiple rounds of chromosome…
  arxiv Po-Yi Ho, Ariel Amir 2015-07-24T21:54:42Z 置信度 0.78 q-bio.CBq-bio.SC
• Improvement in Cell Imaging by Applying a New Natural Dye from Beet Root Extraction
  Fluorescent dyes are getting popularity for last few decades due to their extraordinary applications in cell imaging. We have discovered organic Beet root extracted fluorescent (BREF) dye as an efficient pigment for effective cell imaging. By applying this dye…
  arxiv Arpita Das, Debarati De, Ajay Ghosh, Madhuri Mandal Goswami 2017-10-23T07:27:57Z 置信度 0.78 q-bio.CB
• Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates
  We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contact-inhibition-of-locomotion models to include both cell-cell and cell-substrate a…
  arxiv Luke Coburn, Hender Lopez, Adrian Noppe, Benjamin J. Caldwell 等 2016-04-13T12:37:32Z 置信度 0.78 physics.bio-phq-bio.CBq-bio.TO
• Nearby Supernova Factory Observations of SN 2005gj: Another Type Ia Supernova in a Massive Circumstellar Envelope
  We report Nearby Supernova Factory observations of SN 2005gj, the second confirmed case of a "hybrid" Type Ia/IIn supernova. Our early-phase photometry of SN 2005gj shows that the interaction is much stronger than for the prototype, SN 2002ic. Our first spectr…
  arxiv The Nearby Supernova Factory Collaboration, G. Aldering, P. Antilogus, S. Bailey 等 2006-06-20T21:28:11Z 置信度 0.78 astro-ph
• The effects of stochasticity at the single-cell level and cell size control on the population growth
  Establishing a quantitative connection between the population growth rate and the generation times of single cells is a prerequisite for understanding evolutionary dynamics of microbes. However, existing theories fail to account for the experimentally observed…
  arxiv Jie Lin, Ariel Amir 2016-11-23T21:00:44Z 置信度 0.78 q-bio.PEcond-mat.dis-nncond-mat.stat-mechphysics.bio-ph
• A Toroidal Magnetised Iron Neutrino Detector (MIND) for a Neutrino Factory
  A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An eleg…
  arxiv A. Bross, R. Wands, R. Bayes, A. Laing 等 2013-06-22T14:46:39Z 置信度 0.78 physics.ins-dethep-ex
• Details Matter: noise and model structure set the relationship between cell size and cell cycle timing
  Organisms across all domains of life regulate the size of their cells. However, the means by which this is done is poorly understood. We study two abstracted "molecular" models for size regulation: inhibitor dilution and initiator accumulation. We apply the mo…
  arxiv Felix Barber, Po-Yi Ho, Andrew W. Murray, Ariel Amir 2017-10-17T20:01:57Z 置信度 0.78 q-bio.MNq-bio.CB
• Transfer Learning for T-Cell Response Prediction
  We study the prediction of T-cell response for specific given peptides, which could, among other applications, be a crucial step towards the development of personalized cancer vaccines. It is a challenging task due to limited, heterogeneous training data featu…
  arxiv Josua Stadelmaier, Brandon Malone, Ralf Eggeling 2024-03-18T17:32:19Z 置信度 0.78 q-bio.CBcs.LG
• Slicing for Dense Smart Factory Network: Current State, Scenarios, Challenges and Expectations
  In the era of Industry 4.0, smart factories have emerged as a paradigm shift, redefining manufacturing with the integration of advanced digital technologies. Central to this transformation is the deployment of 5G networks, offering unprecedented levels of conn…
  arxiv Regina Ochonu, Josep Vidal 2024-05-06T07:41:31Z 置信度 0.78 eess.SPeess.SY
• Auto-reverse nuclear migration in bipolar mammalian cells on micropatterned surfaces
  A novel assay based on micropatterning and time-lapse microscopy has been developed for the study of nuclear migration dynamics in cultured mammalian cells. When cultured on 10-20 um wide adhesive stripes, the motility of C6 glioma and primary mouse fibroblast…
  arxiv B. Szabo, Zs. Kornyei, J. Zach, D. Selmeczi 等 2003-10-14T09:18:27Z 置信度 0.78 q-bio.CB
• Is Super-$B$ Sufficiently Superb? -- On the Motivation for a Super-$B$ Factory
  Despite the great success of the $Υ(4S)$ $B$ factories at KEK and SLAC and the guaranteed addition of high sensitivity measurements on beauty decays to be performed at the Tevatron and LHC, a strong case can be made for an $e^+e^-$ Super-$B$ factory yielding d…
  arxiv I. I. Bigi, A. I. Sanda 2004-01-01T16:37:36Z 置信度 0.78 hep-ph
• Self-organization and chaos in the metabolism of a cell
  Aim. To study the dynamics of auto-oscillations arising at the level of enzyme-substrate interaction in a cell and to find the conditions for the self-organization and the formation of chaos in the metabolic process. Methods. A mathematical model of the metabo…
  arxiv V. I. Grytsay, I. V. Musatenko 2018-01-24T13:15:37Z 置信度 0.78 nlin.AOq-bio.CB
• Autocrine signaling and quorum sensing: Extreme ends of a common spectrum
  "Secrete-and-sense cells" can communicate by secreting a signaling molecule while also producing a receptor that detects the molecule. The cell can potentially "talk" to itself ("self-communication") or talk to neighboring cells with the same receptor ("neighb…
  arxiv Berkalp A. Doğaner, Lawrence K. Q. Yan, Hyun Youk 2016-02-18T06:47:49Z 置信度 0.78 q-bio.CB
• The Core & Periphery Hypothesis: A Conceptual Basis for Generality in Cell and Developmental Biology
  The discovery of general principles underlying the complexity and diversity of cellular and developmental systems is a central and long-standing aim of biology. Whilst new technologies collect data at an ever-accelerating rate, there is growing concern that co…
  arxiv Elisa Gallo, Stefano De Renzis, James Sharpe, Roberto Mayor 等 2023-06-15T22:42:36Z 置信度 0.78 q-bio.CBq-bio.PEq-bio.SC
• Molecular-level tuning of cellular autonomy controls the collective behaviors of cell populations
  A rigorous understanding of how multicellular behaviors arise from the actions of single cells requires quantitative frameworks that bridge the gap between genetic circuits, the arrangement of cells in space, and population-level behaviors. Here, we provide su…
  arxiv Théo Maire, Hyun Youk 2016-02-17T20:11:35Z 置信度 0.78 q-bio.MNnlin.CGnlin.PSphysics.bio-phq-bio.CB
• Physics with Low-Energy Muons at a Neutrino Factory Complex
  The physics potential of an intense source of low-energy muons is studied. Such a source is a necessary stage towards building the neutrino factories and muon colliders which are being considered at present. The CERN Neutrino Factory could deliver muon beams w…
  arxiv J. Aysto, A. Baldini, A. Blondel, A. de Gouvea 等 2001-09-24T14:15:43Z 置信度 0.78 hep-phhep-ex
• Vacuum birefringence at the Gamma Factory
  We explore the perspectives of studying vacuum birefringence at the Gamma Factory. To this end, we assess in detail the parameter regime which can be reliably analyzed resorting to the leading contribution to the Heisenberg-Euler effective Lagrangian. We expli…
  arxiv Felix Karbstein 2021-06-11T12:58:12Z 置信度 0.78 hep-ph
• Optimization of the Neutrino Factory, revisited
  We perform the baseline and energy optimization of the Neutrino Factory including the latest simulation results on the magnetized iron detector (MIND). We also consider the impact of tau decays, generated by nu_mu to nu_tau or nu_e to nu_tau appearance, on the…
  arxiv Sanjib Kumar Agarwalla, Patrick Huber, Jian Tang, Walter Winter 2010-12-08T21:11:58Z 置信度 0.78 hep-phhep-exphysics.ins-det
• Stem Cells: The Good, the Bad and the Ugly
  Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different fro…
  arxiv Eric Werner 2016-08-01T15:20:03Z 置信度 0.78 q-bio.TOq-bio.MN
• Charmonium Physics at a Tau-Charm Factory
  This talk summarizes the status of the charmonium system, with particular emphasis on outstanding problems in QCD spectroscopy which a tau-charm factory can address.
  arxiv T. Barnes 1993-08-31T13:51:04Z 置信度 0.78 hep-ph
• The Human Cell Atlas White Paper
  The Human Cell Atlas (HCA) will be made up of comprehensive reference maps of all human cells - the fundamental units of life - as a basis for understanding fundamental human biological processes and diagnosing, monitoring, and treating disease. It will help s…
  arxiv Aviv Regev, Sarah Teichmann, Orit Rozenblatt-Rosen, Michael Stubbington 等 2018-10-11T18:22:25Z 置信度 0.78 q-bio.TO
• Algorithms used for the Cell Segmentation Benchmark Competition at ISBI 2019 by RWTH-GE
  The presented algorithms for segmentation and tracking follow a 3-step approach where we detect, track and finally segment nuclei. In the preprocessing phase, we detect centroids of the cell nuclei using a convolutional neural network (CNN) for the 2D images a…
  arxiv Dennis Eschweiler, Johannes Stegmaier 2019-04-15T07:45:47Z 置信度 0.78 cs.CVq-bio.CB
• Regulation of stem cell dynamics through volume exclusion
  Maintenance and regeneration of adult tissues rely on the self-renewal of stem cells. Regeneration without over-proliferation requires precise regulation of the stem cell proliferation and differentiation rates. The nature of such regulatory mechanisms in diff…
  arxiv Rodrigo García-Tejera, Linus Schumacher, Ramon Grima 2022-04-19T17:02:03Z 置信度 0.78 q-bio.PEq-bio.CB
• 360-LLaMA-Factory: Plug & Play Sequence Parallelism for Long Post-Training
  Adding sequence parallelism into LLaMA-Factory, we open-sourced 360-LLaMA-Factory at https://github.com/Qihoo360/360-LLaMA-Factory. 360-LLaMA-Factory has received wide recognition and used in models such as Light-R1 arXiv:2503.10460, TinyR1 arXiv:2503.04872, K…
  arxiv Haosheng Zou, Xiaowei Lv, Shousheng Jia, Lin Li 等 2025-05-28T12:33:46Z 置信度 0.78 cs.CLcs.LG
• Prospects for light exotic scalar measurements at the e$^+$e$^-$ Higgs factory
  The physics program of the Higgs factory will focus on measurements of the 125 GeV Higgs boson, with the Higgs-strahlung process being the dominant production channel at 250 GeV. However, production of extra light scalars is still not excluded by the existing …
  arxiv Bartłomiej Brudnowski, Kamil Zembaczyński, Aleksander Filip Żarnecki 2024-09-29T20:18:45Z 置信度 0.78 hep-ph
• Coupling of cytoplasm and adhesion dynamics determines cell polarization and locomotion
  Observations of single epidermal cells on flat adhesive substrates have revealed two distinct morphological and functional states, namely a non-migrating symmetric unpolarized state and a migrating asymmetric polarized state. These states are characterized by …
  arxiv Wolfgang Alt, Martin Bock, Christoph Möhl 2009-07-29T09:34:00Z 置信度 0.78 physics.bio-phq-bio.CB
• Purely Leptonic B decays at High Luminosity e+e- B factories
  High Luminosity upgrades of the KEK-B collider are being discussed. We consider the role of the purely leptonic decays B^\pm -> l^\pm nu and B^0 -> l+l- in motivating such an upgrade. These decays are very sensitive to R parity violating extensions of th…
  arxiv A. G. Akeroyd, S. Recksiegel 2002-09-23T04:10:23Z 置信度 0.78 hep-ph
• Sample Factory: Egocentric 3D Control from Pixels at 100000 FPS with Asynchronous Reinforcement Learning
  Increasing the scale of reinforcement learning experiments has allowed researchers to achieve unprecedented results in both training sophisticated agents for video games, and in sim-to-real transfer for robotics. Typically such experiments rely on large distri…
  arxiv Aleksei Petrenko, Zhehui Huang, Tushar Kumar, Gaurav Sukhatme 等 2020-06-21T10:00:23Z 置信度 0.78 cs.LGcs.AIstat.ML
• Axial vs. Radial Junction Nanowire Solar Cell
  Both axial and radial junction nanowire solar cells have their challenges and advantages. However, so far, there is no review that explicitly provides a detailed comparative analysis of both axial and radial junction solar cells. This article reviews some of t…
  arxiv Vidur Raj, Hark Hoe Tan, Chennupati Jagadish 2021-03-24T13:45:53Z 置信度 0.78 cond-mat.mes-hall
• Neutrino Oscillations: Status, Prospects and Opportunities at a Neutrino Factory
  We review the current status of neutrino oscillations after 1258 days of Super-Kamiokande, assess their future prospects over the next 10 years as the next generation of experiments come on-line, and discuss the longer-term opportunities presented by a Neutrin…
  arxiv S. F. King 2001-05-25T12:46:49Z 置信度 0.78 hep-phhep-exhep-th
• Computational investigations into the orgins of 'short term' biochemical memory in T cell activation
  Recent studies have reported that T cells can integrate signals between interrupted encounters with Antigen Presenting Cells (APCs) in such a way that the process of signal integration exhibits a form of memory. Here, we carry out a computational study using a…
  arxiv Jason W. Locasale 2007-06-13T14:10:12Z 置信度 0.78 q-bio.MNphysics.bio-phq-bio.CBq-bio.SC
• RRScell method for automated single-cell profiling of multiplexed immunofluorescence cancer tissue
  Multiplexed immuno-fluorescence tissue imaging, allowing simultaneous detection of molecular properties of cells, is an essential tool for characterizing the complex cellular mechanisms in translational research and clinical practice. New image analysis approa…
  arxiv Alvason Zhenhua Li, Karsten Eichholz, Anton Sholukh, Daniel Stone 等 2020-10-30T06:41:19Z 置信度 0.78 q-bio.QMeess.IVq-bio.TOstat.AP
• Hydrodynamic and rheology of active polar filaments
  The cytoskeleton provides eukaryotic cells with mechanical support and helps them perform their biological functions. It is a network of semiflexible polar protein filaments and many accessory proteins that bind to these filaments, regulate their assembly, lin…
  arxiv Tanniemola B. Liverpool, M. Cristina Marchetti 2007-03-12T14:47:20Z 置信度 0.78 q-bio.CBcond-mat.soft
• A Computational Model Incorporating Neural Stem Cell Dynamics Reproduces Glioma Incidence across the Lifespan in the Human Population
  Glioma is the most common form of primary brain tumor. Demographically, the risk of occurrence increases until old age. Here we present a novel computational model to reproduce the probability of glioma incidence across the lifespan. Previous mathematical mode…
  arxiv Roman Bauer, Marcus Kaiser, Elizabeth Stoll 2015-03-20T17:04:07Z 置信度 0.78 q-bio.CBphysics.bio-phq-bio.TO
• Cell-o1: Training LLMs to Solve Single-Cell Reasoning Puzzles with Reinforcement Learning
  Cell type annotation is a key task in analyzing the heterogeneity of single-cell RNA sequencing data. Although recent foundation models automate this process, they typically annotate cells independently, without considering batch-level cellular context or prov…
  arxiv Yin Fang, Qiao Jin, Guangzhi Xiong, Bowen Jin 等 2025-06-03T14:16:53Z 置信度 0.78 cs.CLcs.AIcs.CEcs.HCcs.LG
• The Case for a Muon Collider Higgs Factory
  We propose the construction of a compact Muon Collider Higgs Factory. Such a machine can produce up to \sim 14,000 at 8\times 10^{31} cm^-2 sec^-1 clean Higgs events per year, enabling the most precise possible measurement of the mass, width and Higgs-Yukawa c…
  arxiv Yuri Alexahin, Charles M. Ankenbrandt, David B. Cline, Alexander Conway 等 2013-07-23T15:50:14Z 置信度 0.78 hep-phphysics.acc-ph
• Statistical and mathematical modeling of spatiotemporal dynamics of stem cells
  Statistical and mathematical modeling are crucial to describe, interpret, compare and predict the behavior of complex biological systems including the organization of hematopoietic stem and progenitor cells in the bone marrow environment. The current prominenc…
  arxiv Walter de Back, Thomas Zerjatke, Ingo Roeder 2018-09-05T19:44:12Z 置信度 0.78 q-bio.QM
• Random Abstract Cell Complexes
  We define a model for random (abstract) cell complexes (CCs), similiar to the well-known Erdős-Rényi model for graphs and its extensions for simplicial complexes. To build a random cell complex, we first draw from an Erdős-Rényi graph, and consecutively augmen…
  arxiv Josef Hoppe, Michael T. Schaub 2024-06-04T06:32:34Z 置信度 0.78 cs.DScs.DMcs.SImath.AT
• Exploring Flavor Structure of Supersymmetry Breaking at B factories
  We investigate flavor physics at present and future B factories in order to distinguish supersymmetric models. We evaluate CP asymmetries in various B decay modes, Delta M(Bd), Delta M(Bs), and epsilon_K in three supersymmetric models, i.e. the minimal supergr…
  arxiv Toru Goto, Yasuhiro Okada, Yasuhiro Shimizu, Tetsuo Shindou 等 2002-11-11T08:41:32Z 置信度 0.78 hep-ph
• The Multi-modality Cell Segmentation Challenge: Towards Universal Solutions
  Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in different experimental …
  arxiv Jun Ma, Ronald Xie, Shamini Ayyadhury, Cheng Ge 等 2023-08-10T21:59:23Z 置信度 0.78 eess.IVcs.CVcs.LGq-bio.QM
• Training a universal instance segmentation network for live cell images of various cell types and imaging modalities
  We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component individually. We modif…
  arxiv Tianqi Guo, Yin Wang, Luis Solorio, Jan P. Allebach 2022-07-28T18:57:30Z 置信度 0.78 cs.CVcs.LG
• Systematically designing better instance counting models on cell images with Neural Arithmetic Logic Units
  The big problem for neural network models which are trained to count instances is that whenever test range goes high training range generalization error increases i.e. they are not good generalizers outside training range. Consider the case of automating cell …
  arxiv Ashish Rana, Taranveer Singh, Harpreet Singh, Neeraj Kumar 等 2020-04-14T17:23:37Z 置信度 0.78 cs.LGcs.NEstat.ML
• Summary of Working Group 3 of the Neutrino Factory '02 Workshop
  The parallel sessions of the working group 3 were devoted to the discussions of short-baseline neutrino physics program at neutrino factories. First, possible studies of parton distribution functions (PDFs), in particular nuclear and polarized PDFs, are discus…
  arxiv A. L. Kataev, S. Kumano 2002-11-05T11:16:09Z 置信度 0.78 hep-phhep-exnucl-exnucl-th
• AR-SFQ: Asynchronous Reset Library Using α-Cell Design
  Rapid Single Flux Quantum (RSFQ) circuits are the most evolved superconductor logic family. However, the need to clock each cell and the deep pipeline causes a complex clock network with a large skew. This results in lower throughput and high latency in RSFQ. …
  arxiv Yasemin Kopur, Beyza Zeynep Ucpinar, Mustafa Altay Karamuftuoglu, Sasan Razmkhah 等 2025-01-16T10:24:25Z 置信度 0.78 cond-mat.supr-con
• Deep Learning in Single-Cell Analysis
  Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high-dimensional, sparse, heterogeneous, and have complicated dependency structures, making analyses using conventiona…
  arxiv Dylan Molho, Jiayuan Ding, Zhaoheng Li, Hongzhi Wen 等 2022-10-22T08:26:41Z 置信度 0.78 q-bio.QMcs.AI
• Grandmother cells and the storage capacity of the human brain
  Quian Quiroga et al. [Nature 435, 1102 (2005)] have recently discovered neurons that appear to have the characteristics of grandmother (GM) cells. Here we quantitatively assess the compatibility of their data with the GM-cell hypothesis. We show that, contrary…
  arxiv John Collins, Dezhe Z. Jin 2006-03-13T20:33:18Z 置信度 0.78 q-bio.NC
• Single-cell protein analysis by mass-spectrometry
  Human physiology and pathology arise from the coordinated interactions of diverse single cells. However, analyzing single cells has been limited by the low sensitivity and throughput of analytical methods. DNA sequencing has recently made such analysis feasibl…
  arxiv Nikolai Slavov 2020-04-05T02:05:20Z 置信度 0.78 q-bio.QMq-bio.BM
• Quantifying evolutionary constraints on B cell affinity maturation
  The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput sequencing. H…
  arxiv Connor O. McCoy, Trevor Bedford, Vladimir N. Minin, Philip Bradley 等 2014-03-12T19:01:41Z 置信度 0.78 q-bio.PE
• Black Hole as a Wormhole Factory
  On general grounds, one may argue that a black hole stops radiation at the Planck mass, where the radiated energy is comparable to the black hole's mass. And also, it has been argued that there would be a "wormhole-like" structure, known as "space-time foam", …
  arxiv Sung-Won Kim, Mu-In Park 2015-02-23T10:30:30Z 置信度 0.78 hep-thgr-qc
• Cell algebra structures on monoid and twisted monoid algebras
  In this paper we study finite monoids M such that the group algebras over a domain R for all Schutzenberger groups of M are cell algebras. We show that for any such M the monoid algebra A over R has a standard cell algebra structure. Using properties of cell a…
  arxiv Robert D. May 2015-01-18T18:47:06Z 置信度 0.78 math.RA
• Dynamic Spectrum Refarming of GSM Spectrum for LTE Small Cells
  In this paper we propose a novel solution called dynamic spectrum refarming (DSR) for deploying LTE small cells using the same spectrum as existing GSM networks. The basic idea of DSR is that LTE small cells are deployed in the GSM spectrum but suppress transm…
  arxiv Xingqin Lin, Harish Viswanathan 2013-05-14T02:08:16Z 置信度 0.78 cs.ITcs.NI
• Cell Segmentation and Tracking using CNN-Based Distance Predictions and a Graph-Based Matching Strategy
  The accurate segmentation and tracking of cells in microscopy image sequences is an important task in biomedical research, e.g., for studying the development of tissues, organs or entire organisms. However, the segmentation of touching cells in images with a l…
  arxiv Tim Scherr, Katharina Löffler, Moritz Böhland, Ralf Mikut 2020-04-03T11:55:28Z 置信度 0.78 cs.CV
• Novel high efficiency quadruple junction solar cell with current matching and quantum efficiency simulations
  A high theoretical efficiency of 47.2% was achieved by a novel combination of In0.51Ga0.49P, GaAs, In0.24Ga0.76As and In0.19Ga0.81Sb subcell layers in a simulated quadruple junction solar cell under 1 sun concentration. The electronic bandgap of these material…
  arxiv Mohammad Jobayer Hossain, Bibek Tiwari, Indranil Bhattacharya 2019-03-23T16:41:02Z 置信度 0.78 physics.app-phphysics.opticsphysics.space-ph
• Multi-stream Cell Segmentation with Low-level Cues for Multi-modality Images
  Cell segmentation for multi-modal microscopy images remains a challenge due to the complex textures, patterns, and cell shapes in these images. To tackle the problem, we first develop an automatic cell classification pipeline to label the microscopy images bas…
  arxiv Wei Lou, Xinyi Yu, Chenyu Liu, Xiang Wan 等 2023-10-22T08:11:08Z 置信度 0.78 cs.CV
• Oscillation Physics with a Neutrino Factory
  A generation of neutrino experiments have established that neutrinos mix and probably have mass. The mixing phenomenon points to processes beyond those of the Standard Model, possibly at the Grand Unification energy scale. A extensive sequence of of experiment…
  arxiv M. Apollonio 2002-10-13T13:46:57Z 置信度 0.78 hep-phhep-ex
• Linear Delay-cell Design for Low-energy Delay Multiplication and Accumulation
  A practical deep neural network's (DNN) evaluation involves thousands of multiply-and-accumulate (MAC) operations. To extend DNN's superior inference capabilities to energy constrained devices, architectures and circuits that minimize energy-per-MAC must be de…
  arxiv Aditya Shukla 2020-07-27T22:25:00Z 置信度 0.78 cs.ETeess.SP
• Modelling and Optimising GaAs/Al(x)Ga(1-x)As Multiple Quantum Well Solar Cells
  The quantum well solar cell (QWSC) is a p - i - n solar cell with quantum wells in the intrinsic region. Previous work has shown that QWSCs have a greater open circuit voltage (Voc) than would be provided by a cell with the quantum well effective bandgap. This…
  arxiv James P. Connolly 2010-06-05T15:56:09Z 置信度 0.78 cond-mat.mes-hallcond-mat.mtrl-sci
• Moon's Radiation Environment and Expected Performance of Solar Cells during Future Lunar Missions
  Several lunar missions are planned ahead and there is an increasing demand for efficient photovoltaic power generation in the moon. The knowledge of solar cell operation in the lunar surface obtained during early seventies need to be updated considering curren…
  arxiv T. E Girish, S Aranya 2010-12-03T12:31:41Z 置信度 0.78 physics.gen-ph
• Analytical Models of Bulk and Quantum Well Solar Cells and Relevance of the Radiative Limit
  The analytical modelling of bulk and quantum well solar cells is reviewed. The analytical approach allows explicit estimates of dominant generation and recombination mechanisms at work in charge neutral and space charge layers of the cells. Consistency of the …
  arxiv James P. Connolly 2011-10-07T15:14:32Z 置信度 0.78 cond-mat.mes-hall
• Raman spectroscopic detection of rapid, reversible, early-stage inflammatory cytokine-induced apoptosis of adult hippocampal progenitors/stem cells
  The role of neuro-inflammation in diverse, acute and chronic brain pathologies is being increasingly recognized. Neuro-inflammation is accompanied by increased levels of both pro- and anti-inflammatory cytokines; these have deleterious as well as protective/re…
  arxiv Uma Ladiwala, Aseefhali Bankapur, Bhushan Thakur, Chidangil Santhosh 等 2014-01-29T12:52:28Z 置信度 0.78 physics.bio-phphysics.chem-phphysics.med-phq-bio.TO
• Global cell-cell communication enables spatial segregation of cells in organoids of the inner cell mass
  During development, cell fates are determined through a combination of intracellular transcriptional regulations and extracellular signaling. As a result, spatial patterns of different cell types arise. We investigate the decision between epiblast and primitiv…
  arxiv Simon Schardt, Sabine C. Fischer 2021-11-02T14:38:08Z 置信度 0.78 q-bio.CBmath.DSphysics.bio-phq-bio.TO
• Scale- free networks in cell biology
  A cell's behavior is a consequence of the complex interactions between its numerous constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling pathways and regulatory mechanisms to coordinate multiple processes, allowing them to respond …
  arxiv Reka Albert 2005-10-28T16:47:56Z 置信度 0.78 q-bio.MN