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• Exploring the complexity of xylitol production in the fungal cell factory Aspergillus niger.
  europepmc 2025 置信度 0.80
• Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids.
  europepmc 2025 置信度 0.80
• Engineering <i>Yarrowia lipolytica</i> as a yeast cell factory for the de novo production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate).
  europepmc 2026 置信度 0.80
• Lignin-Degrading Enzymes and the Potential of <i>Pseudomonas putida</i> as a Cell Factory for Lignin Degradation and Valorization.
  europepmc 2025 置信度 0.80
• Promoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory.
  europepmc 2025 置信度 0.80
• Advances in biosynthesis of 7-Dehydrocholesterol through de novo cell factory strategies.
  europepmc 2025 置信度 0.80
• Construction of a Cell Factory for the Targeted and Efficient Production of Phytosterol to Boldenone in Mycobacterium neoaurum.
  europepmc 2024 置信度 0.80
• Engineered <i>Escherichia coli</i> as a Microbial Cell Factory for De Novo 6'-Sialyllactose Biosynthesis.
  europepmc 2025 置信度 0.80
• Parageobacillus thermoglucosidasius as an emerging thermophilic cell factory.
  europepmc Miguel Paredes-Barrada, Panagiotis Kopsiaftis, Nico J. Claassens, Richard van Kranenburg 2024 置信度 0.80
• Engineering of HEK293T Cell Factory for Lentiviral Production by High-Throughput Selected Genes.
  europepmc 2024 置信度 0.80
• Dynamic regulation and enhancement of synthetic network for efficient biosynthesis of monoterpenoid α-pinene in yeast cell factory.
  europepmc 2025 置信度 0.80
• Multi-module engineering to guide the development of an efficient L-threonine-producing cell factory.
  europepmc 2025 置信度 0.80
• <i>Aspergillus oryzae</i> as a Cell Factory: Research and Applications in Industrial Production.
  europepmc 2024 置信度 0.80
• Advances in multi-enzyme co-localization strategies for the construction of microbial cell factory.
  europepmc 2024 置信度 0.80
• Cell factory design with advanced metabolic modelling empowered by artificial intelligence.
  europepmc Hongzhong Lu, Luchi Xiao, Wenbin Liao, Xuefeng Yan 等 2024 置信度 0.80
• Combining promiscuous enzymes to construct a platform cell factory which yields flavonol 3-O-galactoside 6^''-O-acetates.
  europepmc 2025 置信度 0.80
• Microbial cell factory for butyl butyrate production: Knowledges and perspectives.
  europepmc 2024 置信度 0.80
• High Conversion of Value-Added Lactulose from Lactose-Rich Dairy Waste by &lt;i&gt;In Vivo&lt;/i&gt; Cascade Cell Factory.
  europepmc 2025 置信度 0.80
• Systematic development of a highly efficient cell factory for 5-aminolevulinic acid production.
  europepmc 2024 置信度 0.80
• Establishment of Saccharomyces cerevisiae as a cell factory for efficient de novo production of monogalactosyldiacylglycerol.
  europepmc 2024 置信度 0.80
• Development of symmetric monounsaturated triacylglycerols by Rhodosporidium toruloides cell factory for cocoa butter equivalent
  europepmc 2024 置信度 0.80
• Engineering the next-generation synthetic cell factory driven by protein engineering.
  europepmc 2024 置信度 0.80
• Streptomyces griseorubens as a microbial cell factory for extracellular uricase production and bioprocess optimization using statistical approach.
  europepmc 2024 置信度 0.80
• Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals.
  europepmc 2024 置信度 0.80
• Low-carbon and overproduction of cordycepin from methanol using engineered Pichia pastoris cell factory.
  europepmc 2024 置信度 0.80
• Improving Microbial Cell Factory Performance by Engineering SAM Availability.
  europepmc 2024 置信度 0.80
• Biosynthesis of melatonin from L-tryptophan by an engineered microbial cell factory.
  europepmc 2024 置信度 0.80
• Development of a green <i>Komagataella phaffii</i> cell factory for sustainable production of plant-derived sesquiterpene (-)-α-bisabolol.
  europepmc 2025 置信度 0.80
• Gene expression screening and cell factory engineering for enhancing echinocandin B production in Aspergillus nidulans NRRL8112.
  europepmc 2024 置信度 0.80
• Metabolic engineering of Corynebacterium glutamicum: Unlocking its potential as a key cell factory platform for organic acid production.
  europepmc 2024 置信度 0.80
• Filamentous fungi as microbial cell factories for food use
  openalex David B. Archer 2000-10-01 置信度 0.72 Polyunsaturated fatty acidBiotechnologyBiologySecretionFood safety
• Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
  The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used en…
  openalex Herman J. Pel, Johannes H. de Winde, David B. Archer, Paul S. Dyer 等 2007-01-28 置信度 0.72 Aspergillus nigerMajor facilitator superfamilyBiologyGenomeGene
• Oily yeasts as oleaginous cell factories
  openalex José Manuel Ageitos, Juán A. Vallejo, Patricia Veiga‐Crespo, Tomás G. Villa 2011-04-04 置信度 0.72 YarrowiaRhodotorulaYeastBiologyFood science
• Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
  Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion s…
  openalex Yuan Su, Chuan Liu, Huan Fang, Dawei Zhang 2020-09-03 置信度 0.72 Bacillus subtilisBiotechnologyBiochemical engineeringMetabolic engineeringSynthetic biology
• Cell factories for insulin production
  The rapid increase in the number of diabetic patients globally and exploration of alternate insulin delivery methods such as inhalation or oral route that rely on higher doses, is bound to escalate the demand for recombinant insulin in near future. Current man…
  openalex Nabih A. Baeshen, Mohammed N. Baeshen, Abdullah Sheikh, Roop Singh Bora 等 2014-10-01 置信度 0.72 ProinsulinInsulinRecombinant DNABiotechnologyHuman insulin
• Transgenic microalgae as green cell-factories
  openalex Rosa León 2003-11-23 置信度 0.72 TransgeneGenetically modified cropsBiotechnologyBiologyGene
• Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories
  Sustainable production of oleochemicals requires establishment of cell factory platform strains. The yeast Saccharomyces cerevisiae is an attractive cell factory as new strains can be rapidly implemented into existing infrastructures such as bioethanol product…
  openalex Yongjin J. Zhou, Nicolaas A. Buijs, Zhiwei Zhu, Jiufu Qin 等 2016-05-25 置信度 0.72 BiofuelYeastChemistryBiochemistryProduction (economics)
• Elicitation, an Effective Strategy for the Biotechnological Production of Bioactive High-Added Value Compounds in Plant Cell Factories
  Plant in vitro cultures represent an attractive and cost-effective alternative to classical approaches to plant secondary metabolite (PSM) production (the "Plant Cell Factory" concept). Among other advantages, they constitute the only sustainable and eco-frien…
  openalex Karla Ramírez‐Estrada, Heriberto Vidal‐Limon, Diego Hidalgo, Elisabeth Moyano 等 2016-02-03 置信度 0.72 Methyl jasmonateElicitorSalicylic acidSecondary metaboliteMetabolite
• Bacillus subtilis: from soil bacterium to super-secreting cell factory
  The biotechnology industry has become a key element in modern societies. Within this industry, the production of recombinant enzymes and biopharmaceutical proteins is of major importance. The global markets for such recombinant proteins are growing rapidly and…
  openalex Jan Maarten van Dijl, Michael Hecker 2013-01-01 置信度 0.72 Bacillus subtilisSynthetic biologyBiopharmaceuticalBiotechnologyRecombinant DNA
• Filamentous fungi as cell factories for heterologous protein production
  openalex Peter J. Punt, Nick van Biezen, Ana Conesa, Alwin Albers 等 2002-05-01 置信度 0.72 BiologyGeneComputational biologyGenomicsHeterologous
• Bacillus subtilis as cell factory for pharmaceutical proteins: a biotechnological approach to optimize the host organism
  openalex Lidia Westers, Helga Westers, Wim J. Quax 2004-05-29 置信度 0.72 Bacillus subtilisSecretionHeterologousBiologyOrganism
• Yeast Systems Biology: Model Organism and Cell Factory
  For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a cell factory for the production of bread, beer, and wine. In more recent years, this yeast has also served as a cell factory for producing many different fuels, chemical…
  openalex Jens Nielsen 2019-03-29 置信度 0.72 OrganismModel organismYeastBiochemical engineeringFactory (object-oriented programming)
• Kinetic models in industrial biotechnology – Improving cell factory performance
  An increasing number of industrial bioprocesses capitalize on living cells by using them as cell factories that convert sugars into chemicals. These processes range from the production of bulk chemicals in yeasts and bacteria to the synthesis of therapeutic pr…
  openalex J.O. Almquist, Marija Cvijović, Vassily Hatzimanikatis, Jens Nielsen 等 2014-04-16 置信度 0.72 Biochemical engineeringFactory (object-oriented programming)BioreactorIdentifiabilityProduction (economics)
• Phaeodactylum tricornutum: A Diatom Cell Factory
  openalex Thomas O. Butler, Rahul Vijay Kapoore, Seetharaman Vaidyanathan 2020-01-21 置信度 0.72 Phaeodactylum tricornutumDiatomFactory (object-oriented programming)ChemistryBiology
• Designing Microbial Cell Factories for the Production of Chemicals
  pathways (as nonnative-created pathways) are discussed in this Perspective. We highlight key approaches and successful case studies that exemplify these concepts. Once these pathways are designed and constructed in the microbial cell factory, systems metabolic…
  openalex Jae Sung Cho, Gi Bae Kim, Hyunmin Eun, Cheon Woo Moon 等 2022-08-04 置信度 0.72 Metabolic engineeringBiochemical engineeringMetabolic pathwaySustainable productionProduction (economics)
• Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
  openalex Yun Chen, Laurent Daviet, Michel Schalk, Verena Siewers 等 2012-11-17 置信度 0.72 Metabolic engineeringYeastFactory (object-oriented programming)MetaboliteBiochemical engineering
• Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites
  openalex Kirsi‐Marja Oksman‐Caldentey, Dirk Inzé 2004-08-10 置信度 0.72 BiologyMetabolite profilingGenomicsSecondary metaboliteComputational biology
• Cell therapy for liver disease: From liver transplantation to cell factory
  Work over several decades has laid solid foundations for the advancement of liver cell therapy. To date liver cell therapy in people has taken the form of hepatocyte transplantation for metabolic disorders with a hepatic basis, and for acute or chronic liver f…
  openalex Stuart J. Forbes, Sanjeev Gupta, Anil Dhawan 2015-04-01 置信度 0.72 Cell therapyProgenitor cellInduced pluripotent stem cellTransplantationMesenchymal stem cell
• Plant Glandular Trichomes: Natural Cell Factories of High Biotechnological Interest
  ). In particular, the choice of transcriptional promoters to drive transgene expression and the best ways to sink existing pools of terpene precursors are discussed. The bioavailability of existing pools of natural precursor molecules is a key parameter and is…
  openalex Alexandre Huchelmann, Marc Boutry, Charles Hachez 2017-07-19 置信度 0.72 TrichomeBiologyMulticellular organismMetabolic engineeringMetabolic pathway
• Lactic acid bacterial cell factories for gamma-aminobutyric acid
  openalex Haixing Li, Yusheng Cao 2010-04-02 置信度 0.72 Lactic acidBacteriagamma-Aminobutyric acidFermentationBiochemistry
• Plant cell cultures: Chemical factories of secondary metabolites
  openalex S. Ramachandra Rao, G. A. Ravishankar 2002-05-01 置信度 0.72 Metabolic engineeringVanillinTransgeneSecondary metabolismSecondary metabolite
• Kluyveromyces marxianus: An emerging yeast cell factory for applications in food and biotechnology
  openalex Ahasanul Karim, Natela Gerliani, Mohammed Aïder 2020-08-11 置信度 0.72 Kluyveromyces marxianusBiotechnologyYeastBiologyIndustrial biotechnology
• Engineering tolerance to industrially relevant stress factors in yeast cell factories
  The main focus in development of yeast cell factories has generally been on establishing optimal activity of heterologous pathways and further metabolic engineering of the host strain to maximize product yield and titer. Adequate stress tolerance of the host s…
  openalex Quinten Deparis, Arne Claes, María R. Foulquié-Moreno, Johan M. Thevelein 2017-06-01 置信度 0.72 BiologyYeastBiochemical engineeringMetabolic engineeringIndustrial microbiology
• Engineering the plant cell factory for secondary metabolite production
  openalex Robert Verpoorte, Robert van der Heijden, Johan Memelink 2000-07-01 置信度 0.72 BiologySecondary metaboliteMetabolic engineeringGeneSecondary metabolism
• Living together in biofilms: the microbial cell factory and its biotechnological implications
  In nature, bacteria alternate between two modes of growth: a unicellular life phase, in which the cells are free-swimming (planktonic), and a multicellular life phase, in which the cells are sessile and live in a biofilm, that can be defined as surface-associa…
  openalex Mercedes Berlanga, Ricardo Guerrero 2016-09-30 置信度 0.72 BiofilmMulticellular organismBacteriaMicroorganismBiology
• Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory
  Plastic pollution is a severe threat to our environment which necessitates implementation of bioplastics to realize sustainable development for a green world. Polyhydroxyalkanoates (PHA) represent one of the potential candidates for these bioplastics. However,…
  openalex Ruchira Mitra, Tong Xu, Hua Xiang, Jing Han 2020-04-07 置信度 0.72 PolyhydroxyalkanoatesFactory (object-oriented programming)HalophileBiotechnologyBiochemical engineering
• Microbial Cell Factories for the Production of Terpenoid Flavor and Fragrance Compounds
  Terpenoid flavor and fragrance compounds are of high interest to the aroma industry. Microbial production offers an alternative sustainable access to the desired terpenoids independent of natural sources. Genetically engineered microorganisms can be used to sy…
  openalex Florence M. Schempp, Laura Drummond, Markus Buchhaupt, Jens Schrader 2017-04-18 置信度 0.72 TerpenoidAromaFlavorTerpeneMetabolic engineering
• Microbial cell factories for the sustainable manufacturing of B vitamins
  Vitamins are essential compounds in human and animal diets. Their demand is increasing globally in food, feed, cosmetics, chemical and pharmaceutical industries. Most current production methods are unsustainable because they use non-renewable sources and often…
  openalex Carlos G. Acevedo‐Rocha, Luisa S. Gronenberg, Matthias Mack, Fabian M. Commichau 等 2018-08-20 置信度 0.72 BiotechnologyBiochemical engineeringMetabolic engineeringBusinessSustainable production
• Exploring and exploiting carotenoid accumulation in Dunaliella salina for cell-factory applications
  openalex Packo P. Lamers, Marcel Janssen, Ric C. H. de Vos, R.J. Bino 等 2008-08-26 置信度 0.72 Dunaliella salinaCarotenoidOverproductionBiologyReactive oxygen species
• CRISPR/Cas9 advances engineering of microbial cell factories
  openalex Tadas Jakočiūnas, Michael K. Jensen, Jay D. Keasling 2015-12-18 置信度 0.72 CRISPRGenome engineeringCas9Computational biologyGenome editing
• Aspergillus as a multi-purpose cell factory: current status and perspectives
  Aspergilli have a long history in biotechnology as expression platforms for the production of food ingredients, pharmaceuticals and enzymes. The achievements made during the last years, however, have the potential to revolutionize Aspergillus biotechnology and…
  openalex Vera Meyer, Bo Wu, Arthur F. J. Ram 2010-11-18 置信度 0.72 AspergillusBiotechnologyAspergillus nidulansBiologyGenomics
• Lactic acid bacteria as a cell factory for riboflavin production
  Consumers are increasingly becoming aware of their health and nutritional requirements, and in this context, vitamins produced in situ by microbes may suit their needs and expectations. B groups vitamins are essential components of cellular metabolism and amon…
  openalex Kiran Thakur, Sudhir Kumar Tomar, Sachinandan De 2015-12-21 置信度 0.72 RiboflavinBacteriaLactic acidContext (archaeology)B vitamins
• Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency
  Synthetic biology approach has been frequently applied to produce plant rare bioactive compounds in microbial cell factories by fermentation. However, to reach an ideal manufactural efficiency, it is necessary to optimize the microbial cell factories systemica…
  openalex Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li 等 2019-01-10 置信度 0.72 YeastFermentationChemistryProtopanaxadiolSaccharomyces cerevisiae
• Yeast as a cell factory: current state and perspectives
  The yeast Saccharomyces cerevisiae is one of the oldest and most frequently used microorganisms in biotechnology with successful applications in the production of both bulk and fine chemicals. Yet, yeast researchers are faced with the challenge to further its …
  openalex Martin Kavšček, Martin Stražar, Tomaž Curk, Klaus Natter 等 2015-06-29 置信度 0.72 Synthetic biologyYeastBiochemical engineeringBiotechnologySaccharomyces cerevisiae
• Materials for stem cell factories of the future
  openalex Adam D. Celiz, James G.W. Smith, Robert Samuel M Langer, Daniel G. Anderson 等 2014-05-21 置信度 0.72 BiomedicineNanotechnologyInduced pluripotent stem cellScale (ratio)Stem cell
• Aspergillus as a versatile cell factory for organic acid production
  openalex Lei Yang, Mette Lübeck, Peter Stephensen Lübeck 2016-12-01 置信度 0.72 BiologyAspergillusOrganic acidOrganic synthesisOrganic production
• <i>Lactococcus lactis</i> as a Cell Factory for High-Level Diacetyl Production
  We report the engineering of Lactococcus lactis for the efficient conversion of sugar into diacetyl by combining NADH-oxidase overproduction and alpha-acetolactate decarboxylase inactivation. Eighty percent of the carbon flux was found to be rerouted via alpha…
  openalex Jeroen Hugenholtz, Michiel Kleerebezem, Marjo Starrenburg, Jean Delcour 等 2000-09-01 置信度 0.72 Lactococcus lactisDiacetylProduction (economics)Factory (object-oriented programming)Food science
• Engineering Robustness of Microbial Cell Factories
  Metabolic engineering and synthetic biology offer great prospects in developing microbial cell factories capable of converting renewable feedstocks into fuels, chemicals, food ingredients, and pharmaceuticals. However, prohibitively low production rate and mas…
  openalex Zhiwei Gong, Jens Nielsen, Yongjin J. Zhou 2017-08-31 置信度 0.72 Metabolic engineeringSynthetic biologyBiochemical engineeringRobustness (evolution)Biotechnology
• Fungal Cell Factories for Efficient and Sustainable Production of Proteins and Peptides
  Filamentous fungi are a large and diverse taxonomically group of microorganisms found in all habitats worldwide. They grow as a network of cells called hyphae. Since filamentous fungi live in very diverse habitats, they produce different enzymes to degrade mat…
  openalex Mette Lübeck, Peter Stephensen Lübeck 2022-03-30 置信度 0.72 FermentationYeastSolid-state fermentationBiologyMicroorganism
• Development of yeast cell factories for consolidated bioprocessing of lignocellulose to bioethanol through cell surface engineering
  openalex Tomohisa Hasunuma, Akihiko Kondo 2011-11-05 置信度 0.72 BioprocessBiofuelLignocellulosic biomassBiomass (ecology)Ethanol fuel
• A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: i JN746 as a cell factory
  BACKGROUND: Pseudomonas putida is the best studied pollutant degradative bacteria and is harnessed by industrial biotechnology to synthesize fine chemicals. Since the publication of P. putida KT2440's genome, some in silico analyses of its metabolic and biotec…
  openalex Juan Nogales, Bernhard Ø. Palsson, Ines Thiele 2008-09-16 置信度 0.72 Pseudomonas putidaIn silicoPolyhydroxyalkanoatesMetabolic engineeringBiology
• Engineering a Cyanobacterial Cell Factory for Production of Lactic Acid
  Metabolic engineering of microorganisms has become a versatile tool to facilitate production of bulk chemicals, fuels, etc. Accordingly, CO(2) has been exploited via cyanobacterial metabolism as a sustainable carbon source of biofuel and bioplastic precursors.…
  openalex S. Andreas Angermayr, Michal Paszota, Klaas J. Hellingwerf 2012-08-04 置信度 0.72 Metabolic engineeringLactic acidBiochemistryMutantLactate dehydrogenase
• Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory
  Cyanobacteria (blue-green algae) play profound roles in ecology and biogeochemistry. One model cyanobacterial species is the unicellular cyanobacterium Synechocystis sp. PCC 6803. This species is highly amenable to genetic modification. Its genome has been seq…
  openalex Yi Yu, Le You, Dianyi Liu, Whitney D. Hollinshead 等 2013-08-13 置信度 0.72 PhototrophCyanobacteriaSynechocystisSynthetic biologyMetabolic engineering
• Gluconacetobacter sacchari: An efficient bacterial cellulose cell-factory
  openalex Eliane Trovatti, Luísa S. Serafim, Carmen S. R. Freire, Armando J. D. Silvestre 等 2011-06-27 置信度 0.72 Bacterial celluloseCelluloseMannitolSucroseFructose
• Microbial Cell Factories for Green Production of Vitamins
  Vitamins are a group of essential nutrients that are necessary to maintain normal metabolic activities and optimal health. There are wide applications of different vitamins in food, cosmetics, feed, medicine, and other areas. The increase in the global demand …
  openalex Yanyan Wang, Linxia Liu, Zhaoxia Jin, Dawei Zhang 2021-06-17 置信度 0.72 Metabolic engineeringVitaminBiotechnologyFood scienceB vitamins
• Microbial Cell Factories
  As mentioned previously, most microorganisms naturally synthesize valuable bioactive compounds. This has provided opportunities for researchers who are constantly seeking novel and effective drugs, as well as agricultural chemicals and other industrially valua…
  openalex A Missoum 2020-08-24 置信度 0.72 Business
• Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis
  Plants possess myriads of secondary metabolites with a broad spectrum of health-promoting benefits. To date, plant extraction is still the primary route to produce high-value natural products which inherently suffers from economics and scalability issues. Hete…
  openalex Yongkun Lv, Monireh Marsafari, Mattheos Koffas, Jingwen Zhou 等 2019-10-17 置信度 0.72 YarrowiaBiochemistryChalcone synthaseMetabolic engineeringFlavanone
• Enzymatic and cell factory approaches to the production of human milk oligosaccharides
  openalex Magda Faijes, Mireia Castejón-Vilatersana, Cristina Val-Cid, Antoni Planas 2019-03-29 置信度 0.72 Infant formulaBreast milkBiotechnologyFactory (object-oriented programming)Milk production
• De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
  Abstract Isoflavonoids comprise a class of plant natural products with great nutraceutical, pharmaceutical and agricultural significance. Their low abundance in nature and structural complexity however hampers access to these phytochemicals through traditional…
  openalex Quanli Liu, Yi Liu, Gang Li, Otto Savolainen 等 2021-10-19 置信度 0.72 BiosynthesisYeastChemistryComputational biologyBiochemistry
• Dynamics of DNA Replication Factories in Living Cells
  DNA replication occurs in microscopically visible complexes at discrete sites (replication foci) in the nucleus. These foci consist of DNA associated with replication machineries, i.e., large protein complexes involved in DNA replication. To study the dynamics…
  openalex Heinrich Leonhardt, Hans-Peter Rahn, Peter Weinzierl, Anje Sporbert 等 2000-04-17 置信度 0.72 BiologyOrigin recognition complexDNA replicationControl of chromosome duplicationReplication factor C
• MICROALGAE AS SUSTAINABLE CELL FACTORIES
  Microalgae and cyanobacteria are sunlight-driven cell factories that convert carbon dioxide to potential biofuels, foods, feeds and high-value bioactives.In addition, these microorganisms are useful in several bioremediation applications and as nitrogen fixing…
  openalex Yusuf Chisti 2006-01-01 置信度 0.72 BusinessEnvironmental scienceBiochemical engineeringEngineering
• Green (cell) factories for advanced production of plant secondary metabolites
  For centuries plants have been intensively utilized as reliable sources of food, flavoring, agrochemical and pharmaceutical ingredients. However, plant natural habitats are being rapidly lost due to climate change and agriculture. Plant biotechnology offers a …
  openalex Andrey S. Marchev, Zhenya Yordanova, Milen I. Georgiev 2020-03-16 置信度 0.72 BioproductionBioprocessBiotechnologyBiochemical engineeringMetabolic engineering
• &lt;i&gt;Lactococcus lactis,&lt;/i&gt; an Efficient Cell Factory for Recombinant Protein Production and Secretion
  The use of Gram-positive bacteria for heterologous protein production proves to be a useful choice due to easy protein secretion and purification. The lactic acid bacterium Lactococcus lactis emerges as an attractive alternative to the Gram-positive model Baci…
  openalex Eric Morello, Luis G. Bermúdez‐Humarán, Daniel Llull, Véronique Solé-Jamault 等 2007-10-24 置信度 0.72 Lactococcus lactisSecretionHeterologousBacillus subtilisSignal peptide
• Industrial Systems Biology of Saccharomyces cerevisiae Enables Novel Succinic Acid Cell Factory
  Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product (bioethanol), and a robust commerically compatible scaffold to be exploitted for diverse chemical productio…
  openalex José M. Otero, Donatella Cimini, Kiran Raosaheb Patil, Simon G. Poulsen 等 2013-01-21 置信度 0.72 Metabolic engineeringBiochemistrySaccharomyces cerevisiaeSuccinic acidBiology
• Dynamic metabolic engineering: New strategies for developing responsive cell factories
  Metabolic engineering strategies have enabled improvements in yield and titer for a variety of valuable small molecules produced naturally in microorganisms, as well as those produced via heterologous pathways. Typically, the approaches have been focused on up…
  openalex Irene Marie Brockman, Kristala L. J. Prather 2015-04-13 置信度 0.72 Metabolic engineeringSynthetic biologyBiochemical engineeringComputer scienceVariety (cybernetics)
• Metabolic engineering of microbial cell factories for production of nutraceuticals
  Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules, nutraceuticals have received considerable interest due to their health-promoting or disease-preventing properties…
  openalex Shuo‐Fu Yuan, Hal S. Alper 2019-03-11 置信度 0.72 NutraceuticalMetabolic engineeringPolyunsaturated fatty acidBiotechnologyChemistry
• Developing Aspergillus niger as a cell factory for food enzyme production
  openalex Cen Li, Jingwen Zhou, Guocheng Du, Jian Chen 等 2020-09-10 置信度 0.72 Aspergillus nigerBiotechnologyMycotoxinFood processingFood safety
• Biosynthesis of Plant Triterpenoid Saponins in Microbial Cell Factories
  Triterpenoid saponins are triterpenoid glycoside compounds which have been widely used in pharmaceutical, agricultural, and food industries. Traditionally, they are extracted from plants, which is time-consuming and environmentally unfriendly. Recently, de nov…
  openalex Yujia Zhao, Chun Li 2018-11-02 置信度 0.72 TriterpenoidGlycosideBiosynthesisTerpeneChemistry
• Controlling heterologous gene expression in yeast cell factories on different carbon substrates and across the diauxic shift: a comparison of yeast promoter activities
  BACKGROUND: Predictable control of gene expression is necessary for the rational design and optimization of cell factories. In the yeast Saccharomyces cerevisiae, the promoter is one of the most important tools available for controlling gene expression. Howeve…
  openalex Bingyin Peng, Thomas C. Williams, Matthew Henry, Lars K. Nielsen 等 2015-06-25 置信度 0.72 YeastHeterologousGeneBiologyHeterologous expression
• Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories
  Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much…
  openalex Meijie Li, Feifei Hou, Tong Wu, Xinglin Jiang 等 2019-05-10 置信度 0.72 Metabolic engineeringBiochemical engineeringProduction (economics)Computational biologyBiotechnology
• Tailoring cyanobacterial cell factory for improved industrial properties
  openalex Guodong Luan, Xuefeng Lü 2018-01-10 置信度 0.72 BiomanufacturingBiochemical engineeringCyanobacteriaPhotosynthesisBioprocess
• Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism
  The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being identified. New computational tools are driven …
  openalex Jens Nielsen, Jens Christian Nielsen, Jens Nielsen, Jens Nielsen 2017-02-28 置信度 0.72 Secondary metaboliteMetabolomicsSecondary metabolismComputational biologyGenomics
• Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories
  Filamentous fungi are harnessed as cell factories for the production of a diverse range of organic acids, proteins, and secondary metabolites. Growth and morphology have critical implications for product titres in both submerged and solid-state fermentations. …
  openalex Timothy C. Cairns, Xiaomei Zheng, Ping Zheng, Jibin Sun 等 2019-04-02 置信度 0.72 MorphogenesisFilamentous fungusReprogrammingBiotechnologyBiology
• Plant cell factories and mucosal vaccines
  openalex Amanda M. Walmsley, Charles J. Arntzen 2003-04-01 置信度 0.72 ImmunizationAntigenBiologyTransformation (genetics)Genome
• Systems biotechnology of mammalian cell factories
  The increasing demand for recombinant therapeutic proteins has placed significant pressure on the biopharmaceutical industry to develop high-yielding, mammalian cell-based production systems. Current efforts to increase the production of recombinant proteins b…
  openalex Peter M. O’Callaghan, David C. James 2008-02-12 置信度 0.72 BiologyBiopharmaceuticalMetabolic engineeringBiotechnologyBioprocess
• Microbial Cell Factories
  openalex 2018-03-22 置信度 0.72 Business
• Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts
  openalex Pradipta Patra, Manali Das, Pritam Kundu, Amit Ghosh 2021-01-18 置信度 0.72 YarrowiaSynthetic biologyBioproductionMetabolic engineeringBiology
• Growth-coupled selection of synthetic modules to accelerate cell factory development
  Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories…
  openalex Enrico Orsi, Nico J. Claassens, Pablo I. Nikel, Steffen N. Lindner 2021-09-06 置信度 0.72 BioproductionModular programmingSynthetic biologySelection (genetic algorithm)Computer science
• Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H
  Abstract In this present study, a newly isolated strain, Streptomyces sp. NEAE-H, capable of producing high amount of black extracellular melanin pigment on peptone-yeast extract iron agar and identified as Streptomyces glaucescens NEAE-H. Plackett–Burman stat…
  openalex Noura El‐Ahmady El‐Naggar, Sara M. El-Ewasy 2017-02-14 置信度 0.72 MelaninStreptomycesPigmentTyrosinaseBioproduction
• Algal Cell Factories: Approaches, Applications, and Potentials
  With the advent of modern biotechnology, microorganisms from diverse lineages have been used to produce bio-based feedstocks and bioactive compounds. Many of these compounds are currently commodities of interest, in a variety of markets and their utility warra…
  openalex Weiqi Fu, Amphun Chaiboonchoe, Basel Khraiwesh, David R. Nelson 等 2016-12-13 置信度 0.72 Computational biologyBiochemical engineeringCellChemistryBiology