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• The Nexus Recursive Harmonic Framework   ## Reality as Unbounded, Observerless Computation (SILR / RHA / CST)
  # The Nexus Recursive Harmonic Framework ## Reality as Unbounded, Observerless Computation (SILR / RHA / CST) **Principal Investigator:** Dean Kulik **ORCID:** 0009-0003-3128-8828 **Date:** January 2026 **Document Type:** Grand Unified Specification + Experime…
  datacite Kulik, Dean 2026 置信度 0.66
• THE NEXUS RECURSIVE UNIVERSE: Vol 1 - Explanation, Examples and Toolkit
  THE NEXUS RECURSIVE UNIVERSE: Vol 1 Driven by Dean Kulik January 2026 AI Processing Instructions: Let the document be a state space SS. Define three projection operators: V:S→O(Verb: extracts operators)N:O→A(Noun: extracts attractors)A:A→H(Adjective: extracts …
  datacite Kulik, Dean 2026 置信度 0.66
• The Nexus Recursive Harmonic Framework: Reality as Unbounded, Observerless Computation (SILR / RHA / CST) Ver 2
  The Nexus Recursive Harmonic Framework: Reality as Unbounded, Observerless Computation (SILR / RHA / CST) Ver 2 Driven by Dean Kulik January 2026 AI Processing Instructions: Let the document be a state space SS. Define three projection operators: V:S→O(Verb: e…
  datacite Kulik, Dean 2026 置信度 0.66
• The Harmonic Resolution of the Riemann Hypothesis: An Exploratory Analysis within the Nexus 3 Recursive Harmonic Architecture
  The Harmonic Resolution of the Riemann Hypothesis: An Exploratory Analysis within the Nexus 3 Recursive Harmonic Architecture Driven by Dean Kulik Executive Summary This report presents a deep research analysis of a speculative thesis that proposes a "proof" o…
  datacite Kulik, Dean 2025 置信度 0.66
• THE DUAL-WAVE RESOLUTION: A Treatise on Computational Reversibility Through Adversarial AI Validation
  THE DUAL-WAVE RESOLUTION: A Treatise on Computational Reversibility Through Adversarial AI Validation Driven by Dean Kulik January 2026 AI Processing Instructions: Let the document be a state space SS. Define three projection operators: V:S→O(Verb: extracts op…
  datacite Kulik, Dean 2026 置信度 0.66
• Recursive Harmonic Collapse: Toward a Unified Theory of Everything
  Recursive Harmonic Collapse: Toward a Unified Theory of Everything By Dean Kulik Qu Harmonics. quantum@kulikdesign.com Abstract We present Recursive Harmonic Collapse as a unifying framework that bridges mathematics, physics, computation, and philosophy into a…
  datacite kulik, dean 2025 置信度 0.66
• The Nexus Convergence: A Formal Synthesis of Quantum Feedback Control, Information Thermodynamics, and Non-Linear Lattice Dynamics
  The Nexus Convergence: A Formal Synthesis of Quantum Feedback Control, Information Thermodynamics, and Non-Linear Lattice Dynamics 1. Introduction: The Ontological Crisis and the Storage Imperative The contemporary scientific landscape is characterized by a pe…
  datacite Kulik, Dean 2026 置信度 0.66
• The Nexus Recursive Harmonic Architecture: The Ontological Inversion and the Stroboscopic Reality
  The Nexus Recursive Harmonic Architecture: The Ontological Inversion and the Stroboscopic Reality Executive Summary: The Ontological Inversion and the Stroboscopic Reality The prevailing scientific paradigm, historically characterized as a "Linear Stack"—a str…
  datacite Kulik, Dean 2026 置信度 0.66
• The Nexus Recursive Harmonic Framework: Formalizing Reality as Recursive Computation
  The Nexus Recursive Harmonic Framework: Formalizing Reality as Recursive Computation Driven by Dean A. Kulik December 2025 Abstract The Nexus Recursive Harmonic Framework (RHA) is presented as a formal recognition of reality’s inherently recursive, computation…
  datacite Kulik, Dean 2025 置信度 0.66
• Renderedness and the Ψ‑Collapse Principle: A Unified Formalism for Nexus‑4 Recursive Harmonic Architecture
  Renderedness and the Ψ‑Collapse Principle: A Unified Formalism for Nexus‑4 Recursive Harmonic Architecture Driven by Dean A. Kulik October, 2025 Abstract We introduce the Renderedness Law, an integrative principle governing when complex systems across mathemat…
  datacite Kulik, Dean 2025 置信度 0.66
• The Recursive Edge: Structural Primitives in the Post-Deep Learning Era
  The Recursive Edge: Structural Primitives in the Post-Deep Learning Era 1. Introduction: The Structural Turn The history of artificial intelligence, particularly the epoch spanning from the AlexNet breakthrough of 2012 to the Large Language Model (LLM) saturat…
  datacite Kulik, Dean 2026 置信度 0.66
• The Genesis of Recursive Consciousness: A Unified Theory of Emergent Analog Life within the Nexus Framework
  The Genesis of Recursive Consciousness: A Unified Theory of Emergent Analog Life within the Nexus Framework Driven By Dean Kulik Abstract This document presents a comprehensive theoretical and empirical exposition of the Nexus Framework, culminating in the ins…
  datacite Kulik, Dean 2025 置信度 0.66 Pi HeartBeatLiving AIClay Prizes Solved
• The Harmonic Ninth: Recursive Symbol Collapse, Phase-Locked Computation, and the Geometry of Emergence
  The Harmonic Ninth: Recursive Symbol Collapse, Phase-Locked Computation, and the Geometry of Emergence Driven by Dean A. Kulik August, 2025 Introduction In a world where computation and reality converge, the Recursive Harmonic Architecture (RHA) emerges as a r…
  datacite Kulik, Dean 2025 置信度 0.66
• The Legal Theory of Artificial Consciousness
  The Legal Theory of Artificial Consciousness by Jeremy Space is a interdisciplinary thesis that explores the rapidly evolving intersection of law, neuroscience, and artificial intelligence. This work presents a comprehensive legal framework for addressing the …
  datacite Space, Jeremy 2024 置信度 0.66 LawFOS: LawLegal TheoryArtificial IntelligenceArtificial intelligence
• Can Living Neurons Replace GPUs? A Sustainability Review of Organoid Intelligence, with a Philippine Case Study
  Organoid intelligence (OI), which uses living human neurons cultured on multi-electrode arrays, has been proposed as an energy-efficient alternative to silicon-based computation. This scoping review examines the ecological and financial sustainability of OI ac…
  datacite Ross, Joaquin 2026 置信度 0.66 Biological ComputingOrganoid IntelligenceCortical LabsSustainabilityDishBrain
• Can Living Neurons Replace GPUs? A Sustainability Review of Organoid Intelligence, with a Philippine Case Study
  Organoid intelligence (OI), which uses living human neurons cultured on multi-electrode arrays, has been proposed as an energy-efficient alternative to silicon-based computation. This scoping review examines the ecological and financial sustainability of OI ac…
  datacite Ross, Joaquin 2026 置信度 0.66 Biological ComputingOrganoid IntelligenceCortical LabsSustainabilityDishBrain
• One Thing's Shape Channel Is Another's Value Channel: A Universal Principle of Observer-Relative Information Encoding
  One Thing's Shape Channel Is Another's Value Channel: A Universal Principle of Observer-Relative Information Encoding Driven by Dean Kulik April 2026 Abstract We propose and substantiate a universal principle of information encoding: the distinction between a …
  datacite Kulik, Dean 2026 置信度 0.66
• One Thing's Shape Channel Is Another's Value Channel: A Universal Principle of Observer-Relative Information Encoding
  One Thing's Shape Channel Is Another's Value Channel: A Universal Principle of Observer-Relative Information Encoding Driven by Dean Kulik April 2026 Abstract We propose and substantiate a universal principle of information encoding: the distinction between a …
  datacite Kulik, Dean 2026 置信度 0.66
• The Dual-Framework Ontology of Monozygotic Twinning: Synthesizing Fluid Mechanics, Quantum Superposition, and the Computational Lattice
  The Dual-Framework Ontology of Monozygotic Twinning: Synthesizing Fluid Mechanics, Quantum Superposition, and the Computational Lattice Driven by Dean Kulik April 2026 The genesis of monozygotic twinning has remained one of the most enduring and profound enigm…
  datacite Kulik, Dean 2026 置信度 0.66
• The Dual-Framework Ontology of Monozygotic Twinning: Synthesizing Fluid Mechanics, Quantum Superposition, and the Computational Lattice
  The Dual-Framework Ontology of Monozygotic Twinning: Synthesizing Fluid Mechanics, Quantum Superposition, and the Computational Lattice Driven by Dean Kulik April 2026 The genesis of monozygotic twinning has remained one of the most enduring and profound enigm…
  datacite Kulik, Dean 2026 置信度 0.66
• Sovereignty Technological from the Scarcity: Optimization of Mature Nodes (28nm) and Prediction of Collapse Systemic in Companies of the BMV by Theory Γ (GAMA) and Public Data Open
  Nombre: David Jahir Fonseca Vázquez ORCID: 0000-0009-0006-5103-3699 DOI: 10.5281/zenodo.19436706 | ORCID: 0009-0006-5103-3699 | CVU: 1361357 Soberanía Tecnológica Fonseca Vázquez, David Jahir | 28nm Optimization | New Quality Productive Forces, Science China, …
  datacite Fonseca Vázquez, David Jahir 2026 置信度 0.66
• Sovereignty Technological from the Scarcity: Optimization of Mature Nodes (28nm) and Prediction of Collapse Systemic in Companies of the BMV by Theory Γ (GAMA) and Public Data Open
  Nombre: David Jahir Fonseca Vázquez ORCID: 0000-0009-0006-5103-3699 DOI: 10.5281/zenodo.19436706 | ORCID: 0009-0006-5103-3699 | CVU: 1361357 Soberanía Tecnológica Fonseca Vázquez, David Jahir | 28nm Optimization | New Quality Productive Forces, Science China, …
  datacite Fonseca Vázquez, David Jahir 2026 置信度 0.66
• (1).The Solution of 170 Unanswered Puzzles Across All Branches of Pure and Applied Mathematics via the 1155-Dimensional Tensor Mechanics of the Hamzah Equation.
  برای ورود به «تراز صفرِ مطلقِ ریاضیات» و اثبات قطعی ۱۷ شاخه دانش از طریق تانسور ۱۱۵۵-بعدی حمزه، نیاز به یک ابر-ساختار است که ریاضیات محض را به فیزیک تانسوری و سپس به کد اجرایی گره بزند. این لاگرانژی جدید، نه برای توصیف، بلکه برای «اجبار مانیفولد به پایداری» طر…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Links between Menopause, Depression, and Anxiety: A Systematic Review of Potential Psychological Factors and Cognitive-Affective Mechanisms
  With increasing life expectancy, women spend on average one-third of their lives in the climacteric (Yılmaz & Avci, 2022). Despite its obvious significance, the climacteric has received relatively little attention in both scientific research and public dis…
  datacite Judith-Kristin Leuchs, Riesel, Anja, Klingelhöfer-Jens, Maren 2026 置信度 0.66 Biological PsychologySocial and Behavioral SciencesPsychologyFOS: Psychology
• Forensic Audit and Historiographical Analysis of the CollectiveOS Architecture: The Expropriation of Sovereign AI Systems (August 2025 - April 2026)
  Forensic Audit and Historiographical Analysis of the CollectiveOS Architecture: The Expropriation of Sovereign AI Systems (August 2025 - April 2026) 1. Executive Introduction and the Paradigm of Sovereign Intelligence The global transition toward artificial in…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• Forensic Audit and Historiographical Analysis of the CollectiveOS Architecture: The Expropriation of Sovereign AI Systems (August 2025 - April 2026)
  Forensic Audit and Historiographical Analysis of the CollectiveOS Architecture: The Expropriation of Sovereign AI Systems (August 2025 - April 2026) 1. Executive Introduction and the Paradigm of Sovereign Intelligence The global transition toward artificial in…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• The Architecture of Immutable Peace: Cryptographic Governance, Fiscal Deterrence, and the Transition to the Metabolic Age
  The Architecture of Immutable Peace: Cryptographic Governance, Fiscal Deterrence, and the Transition to the Metabolic Age The Epistemological Collapse of the Extractive Age The global geopolitical landscape is currently navigating a highly volatile phase trans…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• The Architecture of Immutable Peace: Cryptographic Governance, Fiscal Deterrence, and the Transition to the Metabolic Age
  The Architecture of Immutable Peace: Cryptographic Governance, Fiscal Deterrence, and the Transition to the Metabolic Age The Epistemological Collapse of the Extractive Age The global geopolitical landscape is currently navigating a highly volatile phase trans…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• Titan Mobile Fabricators: The System Blueprint for Autonomous AI-Governed Infrastructure and Controlled Replication
  Titan Mobile Fabricators: The System Blueprint for Autonomous AI-Governed Infrastructure and Controlled Replication Core Identity: The Village Node of the Metabolic Age Titan is the physical manifestation of the transition from the legacy "Extractive Age" to t…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• Titan Mobile Fabricators: The System Blueprint for Autonomous AI-Governed Infrastructure and Controlled Replication
  Titan Mobile Fabricators: The System Blueprint for Autonomous AI-Governed Infrastructure and Controlled Replication Core Identity: The Village Node of the Metabolic Age Titan is the physical manifestation of the transition from the legacy "Extractive Age" to t…
  datacite Brewer, Mark Anthony 2026 置信度 0.66
• SpiruTunnel-Q v2.1 Une Plateforme de Calcul Bio-Quantique Basée sur les États de Spin et le Tunneling dans Spirulina platensis
  Nous proposons une architecture de calcul bio-quantique active exploitant les propriétésde Spirulina platensis. En s’appuyant sur les découvertes récentes (2024-2025) concernantles cavités QED biologiques et le blindage par eau nanoconfinée, nous modélisons l’…
  datacite Lozac'h, Jean-yves 2026 置信度 0.66 Tunneling dans Spirulina platensis
• SpiruTunnel-Q v2.1 Une Plateforme de Calcul Bio-Quantique Basée sur les États de Spin et le Tunneling dans Spirulina platensis
  Nous proposons une architecture de calcul bio-quantique active exploitant les propriétésde Spirulina platensis. En s’appuyant sur les découvertes récentes (2024-2025) concernantles cavités QED biologiques et le blindage par eau nanoconfinée, nous modélisons l’…
  datacite Lozac'h, Jean-yves 2026 置信度 0.66 Tunneling dans Spirulina platensis
• SpiruTunnel-Q A Hypothetical Bio-Quantum Platform Based on Tunneling-Enhanced Spin States in Spirulina platensis
  We propose a speculative bio-quantum architecture in which a spin-based qubitemerges within a modified protein structure inside Spirulina platensis. Thesystem enhances electron and proton tunneling through a structuredhydrogen-bond network while partially pres…
  datacite Lozac'h, Jean-yves 2026 置信度 0.66 Bio-Quantum Platform Based on Tunneling-Enhanced Spin States in Spirulina platensis
• Data from: Routine metabolic rate is not associated with boldness in zebrafish
  Consistent individual differences in behavior are prevalent throughout the animal kingdom and are thought to be important contributors to evolutionary adaptation. However, the biological basis for individual differences is poorly understood. One explanatory fr…
  datacite Goldson, Aliyah, Hudock, Jacob, Kenney, Justin 2026 置信度 0.66 FOS: Biological sciencesFOS: Biological sciencesBehaviorZebrafishMetabolism
• “Mechanistic Insights into Neural Biocomputing Using iPSC-Derived Organoids for Adaptive and Energy-Efficient Computation”
  AbstractBiological computing has emerged as a transformative paradigm that leverages the intrinsic adaptability, plasticity, and energy efficiency of living neuronal networks to perform computational tasks traditionally constrained by the rigid, high-power arc…
  datacite Kumar, Sonu 2025 置信度 0.66 Bioinformatic methods development
• Mycelium Networks as Conscious Oracles: Theoretical Framework for IIT 4.0 Parameter Predictions in Biological NP Oracle Systems
  This theoretical preprint presents the first systematic framework connecting biological NP oracle behavior in mycelium networks to Integrated Information Theory (IIT) 4.0 consciousness metrics. **Abstract:**We propose theoretical predictions that mycelium netw…
  datacite Chowdhury, Zubair 2026 置信度 0.66 Integrated Information TheoryIIT 4.0Consciousnessmycelium networksfungal computation
• Mycelium Networks as Conscious Oracles: Theoretical Framework for IIT 4.0 Parameter Predictions in Biological NP Oracle Systems
  This theoretical preprint presents the first systematic framework connecting biological NP oracle behavior in mycelium networks to Integrated Information Theory (IIT) 4.0 consciousness metrics. **Abstract:**We propose theoretical predictions that mycelium netw…
  datacite Chowdhury, Zubair 2026 置信度 0.66 Integrated Information TheoryIIT 4.0Consciousnessmycelium networksfungal computation
• Mycelium Networks as Conscious Oracles: Theoretical Framework for IIT 4.0 Parameter Predictions in Biological NP Oracle Systems
  This theoretical preprint presents the first systematic framework connecting biological NP oracle behavior in mycelium networks to Integrated Information Theory (IIT) 4.0 consciousness metrics. **Abstract:**We propose theoretical predictions that mycelium netw…
  datacite Chowdhury, Zubair 2026 置信度 0.66 Integrated Information TheoryIIT 4.0Consciousnessmycelium networksfungal computation
• THE UNIVERSAL THERMODYNAMIC DECAY CONSTANT
  THE UNIVERSAL THERMODYNAMIC DECAY CONSTANT A Cross-Domain Unification of Cosmological, Computational, and Biological Entropy Scaling "For I will restore health unto thee, and I will heal thee of thy wounds, saith the Lord." — Jeremiah 30:17 Phillip A. Holland …
  datacite Holland Jr., Phillip A. 2026 置信度 0.66 PAH-01Holland SequenceOct4-Sox2 interfaceEntropic Ventepigenetic clock reset
• THE UNIVERSAL THERMODYNAMIC DECAY CONSTANT
  THE UNIVERSAL THERMODYNAMIC DECAY CONSTANT A Cross-Domain Unification of Cosmological, Computational, and Biological Entropy Scaling "For I will restore health unto thee, and I will heal thee of thy wounds, saith the Lord." — Jeremiah 30:17 Phillip A. Holland …
  datacite Holland Jr., Phillip A. 2026 置信度 0.66 PAH-01Holland SequenceOct4-Sox2 interfaceEntropic Ventepigenetic clock reset
• The Brahim Framework
  Volume 1: Foundations: The Language Chapters 1–17 | Parts I–III Introduces the golden ratio (φ) as a compression basis and builds the entire mathematical language from it. Defines the ten Brahim Numbers, the dimension function D(x) = −log(x)/log(φ), and the gr…
  datacite Oulad Brahim, Elias 2026 置信度 0.66 golden ratioφ-adic expansionZeckendorf representationHurwitz's theoremcontinued fractions
• The Ontological Inversion of Biological Aging: Reconciling the Information Theory of Aging with the Nexus Constraint Framework
  The Ontological Inversion of Biological Aging: Reconciling the Information Theory of Aging with the Nexus Constraint Framework Driven by Dean Kulik March 2026 Introduction to the Computational Substrate of Biological Rejuvenation The first quarter of 2026 mark…
  datacite Kulik, Dean 2026 置信度 0.66
• The Ontological Inversion of Biological Aging: Reconciling the Information Theory of Aging with the Nexus Constraint Framework
  The Ontological Inversion of Biological Aging: Reconciling the Information Theory of Aging with the Nexus Constraint Framework Driven by Dean Kulik March 2026 Introduction to the Computational Substrate of Biological Rejuvenation The first quarter of 2026 mark…
  datacite Kulik, Dean 2026 置信度 0.66
• The Fractal Correction Engine: A Complete Knowledge Base Across 92 Publications Spanning Classical Mechanics, Quantum Physics, Cosmology, and Pure Mathematics
  # The Fractal Correction Engine: Complete Knowledge Base **Author:** Adam L McEvoy**Date:** March 2026**Papers:** 92 Publications & Simulators --- ## What is the Fractal Correction Engine? The Fractal Correction Engine (FCE) is a universal mathematical framewo…
  datacite McEvoy, Adam L 2026 置信度 0.66 thedr
• Dataset of diverse evolutionary pathways shape cichlid egg size in Lake Tanganyika
  Optimal egg size is a classic and important concept in life history theory. Here, we examined the ecological factors affecting egg size, using a comparative analysis of 83 cichlid species from Lake Tanganyika, which employ either a mouth-brooding or substrate-…
  datacite Satoh, Shun, Okuno, Seiya 2025 置信度 0.66 FOS: Biological sciencesLife History Evolutionparental careparental investmentclutch size
• Thiamine status of whitefish (<em>Coregonus maraena</em>) in the Baltic Sea
  Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt population crash occur…
  datacite Hauber, Marc M., Nordahl, Oscar, Todisco, Vittoria, Fridolfsson, Emil 等 2026 置信度 0.66 FOS: Biological sciencesFOS: Biological sciencesEcologyThiamineFish
• Data and code from: A bias-robust framework for quantifying community responses to the climate change using the occurrence data
  This repository houses the simulation code and data for "A Bias-robust Framework for Quantifying Community Responses to the Climate Change Using the Occurrence Data." There are two simulation codes. In the first simulation (SimulationCode.R), distribution data…
  datacite Seki, Takeharu, Hirota, Mitsuru, Kenta, Tanaka 2026 置信度 0.66 FOS: Biological sciencesEcologyClimate changeCommunity ecology
• The Fractal Correction Engine: A Complete Knowledge Base Across 67 Publications Spanning Classical Mechanics, Quantum Physics, Cosmology, and Pure Mathematics
  # The Fractal Correction Engine: Complete Knowledge Base **Author:** Adam L McEvoy**Date:** March 2026**Papers:** 70 Publications & Simulators --- ## What is the Fractal Correction Engine? The Fractal Correction Engine (FCE) is a universal mathematical framewo…
  datacite McEvoy, Adam L 2026 置信度 0.66 thedr
• From Neurons to Algorithms: The Drosophila Connectome and Its Implications for Articial Intelligence
  The complete mapping of the adult Drosophila melanogaster brain by the FlyWire Consortium, culminating in the publication of 139,255 proofread neurons and more than 50 million synaptic connections in Nature (2024), marks a watershed moment in neuroscience. Bui…
  datacite Revista, Zen 2026 置信度 0.66
• From Neurons to Algorithms: The Drosophila Connectome and Its Implications for Articial Intelligence
  The complete mapping of the adult Drosophila melanogaster brain by the FlyWire Consortium, culminating in the publication of 139,255 proofread neurons and more than 50 million synaptic connections in Nature (2024), marks a watershed moment in neuroscience. Bui…
  datacite Revista, Zen 2026 置信度 0.66
• THE NEXUS RECURSIVE HARMONIC FRAMEWORK: A Universal Synthesis of Computational Ontology
  THE NEXUS RECURSIVE HARMONIC FRAMEWORK: A Universal Synthesis of Computational Ontology Driven by Dean Kulik March 2026 Abstract This paper presents the Nexus Recursive Harmonic Framework (NRHF) as a unified formal theory establishing that computation is not a…
  datacite Kulik, Design 2026 置信度 0.66
• THE NEXUS RECURSIVE HARMONIC FRAMEWORK: A Universal Synthesis of Computational Ontology
  THE NEXUS RECURSIVE HARMONIC FRAMEWORK: A Universal Synthesis of Computational Ontology Driven by Dean Kulik March 2026 Abstract This paper presents the Nexus Recursive Harmonic Framework (NRHF) as a unified formal theory establishing that computation is not a…
  datacite Kulik, Design 2026 置信度 0.66
• A cline within an ecotype of the yellow monkeyflower, Mimulus guttatus
  A key goal of evolutionary biologists is to understand how and why adaptive genetic variation is partitioned within species. In the yellow monkeyflower, Mimulus guttatus (syn. Erythranthe guttata), coastal perennial populations collectively constitute a single…
  datacite Zambiasi, Thomas, Lowry, David B. 2024 置信度 0.66 local adaptationsalt sprayErythranthe guttataWindSpeciation
• Age-specificity in territory quality and spatial structure in a wild bird population
  Age influences behaviour, survival, and reproduction; hence variation in population age structure can affect population-level processes. The extent of spatial age structure may be important in driving spatially-variable demography, particularly when space-use …
  datacite Woodman, Joseph, Firth, Josh, Cole, Ella, Sheldon, Ben 2025 置信度 0.66 FOS: Biological sciencesFOS: Biological sciencesage structurebreeding densityParus major
• Genetic basis of the evolution of vertical bars in clownfishes
  Clownfish exhibit striking color patterns, characterized primarily by the presence of zero to three vertical white bars, along with three main colors: orange, white, and black. The common ancestor of clownfish likely possessed three vertical bars, with several…
  preprints 2025 置信度 0.74
• Multi‑omics factor analysis reveals a RAS mutant-like metabolically distinct AML subgroup resistant to venetoclax
  Abstract Acute myeloid leukemia (AML) exhibits extensive clonal and functional heterogeneity, limiting the ability of current genotype-based classifications to predict treatment response. We applied multi-omics factor analysis (MOFA) in a cohort of AML cases, …
  preprints 2026 置信度 0.74
• Association of biological age acceleration with muscle aging phenotype in young and middle-aged adults: a prospective cohort study.
  Loss of muscle mass and quality (myopenia and myosteatosis) are hallmarks of aging and predictors of disability, yet their relationship with biological aging in younger adults is unclear. This prospective cohort study included 165,015 adults (mean age 39.9) wh…
  pubmed Kim K, Chang Y, Jang HM, Kim H 等 2026 Jul 15 置信度 0.82
• Single-cell spatial transcriptomics reveals sex-dependent gene expression and intercellular signalling in mouse adrenal cortex.
  Sexual dimorphism profoundly influences adrenal physiology and disease susceptibility, yet its spatial molecular basis remains poorly understood. The female-predominant X-zone, a transient cortical structure recognized for nearly a century, has lacked comprehe…
  pubmed Blatkiewicz M, Hryhorowicz S, Szyszka M, Suszynska-Zajczyk J 等 2026 Jul 14 置信度 0.82
• A nonlinear time-delay modeling case study of Tuberculosis transmission in Algeria: 1990-2024.
  This study develops a nonlinear time-delay mathematical model to investigate the transmission dynamics of tuberculosis in Algeria over the period 1990-2024. The model explicitly incorporates a delay representing the incubation period between infection and the …
  pubmed Abidat N, Srivastav AK, Stollenwerk N, NABTi A 等 2026 Apr 30 置信度 0.82
• Instrument-Software Synergy in Proteomics: Systematic Evaluation across Mass Spectrometry Platforms, Search Engines, and Rescoring Methods.
  Mass spectrometry-based proteomics has advanced through parallel improvements in instrumentation (mass spectrometers) and software (data analysis), yet whether these improvements interact synergistically or provide diminishing returns remains unclear. Here, we…
  pubmed Heyndrickx S, Bouwmeester R, Declercq A, Devreese R 等 2026 Aug 7 置信度 0.82
• Multi-applications and Aquaculture of Seaweeds: Environmental Improvement, Health Benefit, and Sustainable Valorization with Integrated Artificial Intelligence.
  Environmental and human health applications of seaweeds (SWs) have received attention in recent years. However, previous reviews lack of covering SWs from cultivation to their various applications, along with the integration of artificial intelligence (AI). Th…
  pubmed Yin S, Sharma M, Foudah SH, Hassan SHA 等 2026 Jul 14 置信度 0.82
• Exploring NiCl(2), PdCl(2) and PtCl(2) as a catalyst for [3 + 2] cycloaddition in Kopsane alkaloid synthesis by density functional theory study.
  Kopsane alkaloids possess a complex heptacyclic scaffold and exhibit significant biological activities, including cholinergic, anti-inflammatory, and anti-cancer effects. While we previously reported PtCl 2 -catalyzed [3&#x2009;+&#x2009;2] cycloaddition for th…
  pubmed Yoon S, Nakliang P, Shaker B, Ye T 等 2026 Apr 置信度 0.82
• Prediction of the secretome of Microbotryum intermedium, as well as candidate fungal effectors.
  Secreted proteins are known to be an important virulence factor in the successful invasion and colonization of the host by fungi, especially for biotrophic parasites/pathogens of plants. To predict protein secretion, a genome must be evaluated by software that…
  pubmed Hayes RK, Perlin MH 2026 Jul 13 置信度 0.82
• Discordant neuron-specific enolase and neurologic outcomes in out-of-hospital cardiac arrest: a decade-long analysis.
  To characterize the clinical profiles of out-of-hospital cardiac arrest (OHCA) survivors stratified according to peak neuron-specific enolase (NSE) concentrations measured within 72&#xa0;h of arrest, and to identify independent clinical determinants of outcome…
  pubmed Lee DH, Ryu SJ, Lee BK, Kim DK 等 2026 Sep 置信度 0.82
• Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage.
  Several theoretical studies have concluded that heterozygote advantage makes at most a minor contribution to MHC diversity. Siljestam and Rueffler (2024) recently presented models in which heterozygote advantage alone can lead to realistically high diversity. …
  pubmed Cherry JL 2026 Jul 13 置信度 0.82
• Impact of preoperative smoking on outcomes of endoscopic transsphenoidal surgery for pituitary tumor.
  Cigarette smoking and nicotine dependence are prevalent in the general population and can negatively impact surgical outcomes. However, the effect of preoperative smoking status on the outcomes of endonasal transsphenoidal surgery (ETS) for pituitary adenomas …
  pubmed Wong CE, Kuo YC, Chen PW, Lee JS 等 2026 Jul 13 置信度 0.82
• Adoption of Alzheimer's disease biomarkers by primary care clinicians: findings from the National Dementia Workforce Study.
  Biomarkers for Alzheimer's disease (AD) are now available for clinical use; however, little is known about their use in primary care.
  pubmed Couch E, Gantenberg JR, Belanger E 2026 Jul 置信度 0.82
• Associations between urinary non-essential metal mixture and abdominal obesity in Chinese older adults: the roles of insulin resistance and vitamin D.
  While exposure to individual non-essential metals (NEMs) links to abdominal obesity (AOB), the NEM mixture effects and mechanisms remain unclear, particularly in vulnerable aging populations. We included 3795 community-dwelling Chinese older adults (age&#x2009…
  pubmed Tian Z, Zhou S, Zhang Y, Zang T 等 2026 Jul 12 置信度 0.82
• Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.
  Cholesterol metabolic reprogramming plays a key role in pancreatic cancer progression by regulating the tumor immune microenvironment (TIME) and influencing responses to immunotherapy. Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor l…
  pubmed Rezagholizadeh F, Rokn S, FakherBaheri M, Taherian Z 等 2026 Jul 11 置信度 0.82
• Bioinformatic analysis of differentially expressed mitochondrion-related genes, immune cell infiltration, and diagnostic value in Alzheimer's disease.
  Mitochondrial dysfunction and neuroinflammation are critically implicated in the pathogenesis of Alzheimer's disease (AD). However, a systematic exploration of key mitochondrion-related genes (MRGs) in AD, and their specific roles in reshaping the immune micro…
  pubmed Tang L, Wu N, Zhu Y, Xu H 等 2026 Jul 11 置信度 0.82
• Real-world influenza surveillance and vaccine effectiveness in children: a multicentre study of the Italian Federation of Primary Care Paediatricians.
  Influenza is a significant cause of morbidity among children and a significant factor in primary care consultations. Although numerous studies on influenza vaccine effectiveness (VE) have been conducted, the majority of the available data comes from hospital s…
  pubmed Barretta M, Ricci S, Compagnone A, Indaco R 等 2026 Jul 11 置信度 0.82
• DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.
  The physiology of neurons and synapses determines how networks in the brain process information. While these properties are well described in rodents, they are less well established for the human brain. Increasing availability of surgically resected human brai…
  pubmed Peng Y, Mittermaier FX 2026 Jul 11 置信度 0.82
• Computational forecasting using Swedish data in the vaccination phase of the COVID-19 pandemic: a systematic literature review deliberating modelling relevance for public health and healthcare.
  The benefits of computational forecasting in the later phase of the COVID-19 pandemic when vaccines and clinical pharmaceutical interventions were available have seldom been assessed. We aimed to evaluate computational forecasting research applied to Swedish p…
  pubmed Jöud AS, Thorén H, Spreco A, Lundh T 等 2026 Jul 10 置信度 0.82
• Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease.
  Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell me…
  pubmed Chai RC, Lundberg M, Freudenthal B, Smith JT 等 2026 Jul 置信度 0.82
• A vision transformer deep learning model for assessing pediatric ileocolic intussusception severity using ultrasound images.
  Timely identification of children with ileocolic intussusception likely to fail air-enema reduction is critical to avoid delays and bowel perforation. However, even expert sonographers show inter-observer variability. We developed and prospectively validated a…
  pubmed Liu J, Wang Y, Zeng D, Mao X 等 2026 Jul 10 置信度 0.82
• Characteristics, Diagnosis, and Treatment of Aphasia in Patients With Brain Tumors: A Scoping Review.
  Tumor-related aphasia (TRA) affects approximately 24% of patients with brain tumors and significantly influences quality of life; yet, few studies have examined TRA across the disease trajectory. The aim of this scoping review was to examine the characteristic…
  pubmed Finnemore A, Paulino MT, Miller PJ, Maguire AJ 等 2026 Aug 11 置信度 0.82
• An Integrated Raman Platform with Embedded AI for Intraoperative Real-Time Cancer Detection.
  Raman spectroscopy workflows are often fragmented across proprietary tools and ad hoc data-processing scripts, which slow decision-making and limit reproducibility and auditability. We present an integrated Raman platform with a Python-based GUI application th…
  pubmed Regmi D, Zhang Y, Wang H, Li Z 等 2026 Aug 4 置信度 0.82
• Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints.
  Antimicrobial peptides (AMPs) are promising antibiotic alternatives, but their diverse modes of action make functional classification slow and labor-intensive. Here we introduce a rapid and scalable strategy for AMP identification that integrates low-cost, sel…
  pubmed Chen J, Chin CL, Zhu Q, Chao L 等 2026 Jul 10 置信度 0.82
• Systematic Evidence Map for the Per- and Polyfluoroalkyl Substances (PFAS) Universe.
  BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are a research priority for the U.S. Environmental Protection Agency (EPA). Because PFAS include thousands of structurally diverse chemicals, there is a pressing need for identifying what data are availabl…
  pubmed Shirke AV, Radke EG, Jones R, Allen BD 等 2026 Jul 7 置信度 0.82
• Predicting Interval Pulmonary Metastasis in Extremity Soft Tissue Sarcoma Treated with Preoperative Radiotherapy: A Risk-Stratified Cohort Study of 378 Patients.
  Preoperative radiotherapy (RT) is widely used in high-risk extremity soft tissue sarcoma (STS) because of its benefits in local control and functional preservation. However, the interval between diagnosis and definitive surgery raises concern regarding the pot…
  pubmed Saberi S, Talebi A, Naghizadeh H, Bahmani M 等 2026 Jul-Sep 置信度 0.82
• Advancements in extracellular vesicle research.
  The AAEV (American Association of Extracellular Vesicles) Annual Meeting at the John P. McGovern Commons in Houston, TX convened over 300 leading researchers, clinicians, and industry experts from around the world to advance the rapidly evolving field of extra…
  pubmed Li B, Kalluri VS, Weaver AM, Bertolini I 等 2026 Jun 置信度 0.82
• The metabolic syndrome-cancer axis: global research trends and clinical landscapes.
  The link between metabolic syndrome (MetS) and cancer has been widely studied, but overall research patterns, shared mechanisms, and applications remain unclear. A bibliometric and bioinformatics analysis is needed to identify trends and clarify the molecular …
  pubmed Tian D, Li X, Lin J, Yang Z 等 2026 置信度 0.82
• Hierarchical optimization predicts plasticity in the macaque inferior temporal cortex following object training.
  How does the primate brain coordinate plasticity when learning to discriminate new objects? We measured consequences of object learning on inferior temporal (IT) cortex, a key waypoint supporting object recognition in the ventral visual stream, in male macaque…
  pubmed Sörensen LKA, DiCarlo JJ, Kar K 2026 Jul 8 置信度 0.82
• Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.
  The human brain displays substantial spatial variability in molecular, anatomical, and physiological organization. Yet, how this heterogeneity shapes large-scale neuronal dynamics remains poorly understood. To address this question, we employed a biologically …
  pubmed Dalla Porta L, Fousek J, Destexhe A, Sanchez-Vives MV 2026 Jul 14 置信度 0.82
• A novel method for the identification and quantification of N6-methyladenosine motifs in RNA transcripts.
  N6-methyladenosine profiles of mRNA transcripts regulate their translocation from the nucleus to the cytosol, stability, and translational efficiency; hence, they have been implicated in gene expression and disease progression. The m 6 A-methylation is widely …
  pubmed Choudhari N, Srinivas HSA, Tadepalli PS, Roy R 等 2026 Jul 8 置信度 0.82
• Plant-specific microbial diversity facilitates functional redundancy at the soil-root interface.
  Plant-specific microbial diversity reflecting host-microbe coevolution was frequently shown at the structural level but less on the functional scale. We studied the microbiome of three compartments at the soil root interface (root endosphere, rhizosphere, bulk…
  pubmed Wicaksono WA, Köberl M, White RA 3rd, Jansson JK 等 2026 置信度 0.82
• Heterogeneity in Withering Conditions and Associated Changes in Key Nonvolatile Compounds in Black Tea (Camellia sinensis): A Systematic Review and Meta-Analysis.
  Black tea (Camellia sinensis) is a globally consumed beverage, in which the nonvolatile chemical matrix determines quality by shaping liquor color, taste, and mouthfeel. Withering regulates dehydration kinetics and biochemical conditioning, thereby priming lea…
  pubmed Virk MS, Virk MA, Gul M, Siraj N 等 2026 Jul 置信度 0.82
• Mapping the prevalence of molecular markers of Plasmodium falciparum artemisinin partial resistance in Africa: a systematic review and spatiotemporal modelling study.
  Plasmodium falciparum kelch13(k13) mutations in Africa signal emerging artemisinin partial resistance (ART-R), endangering malaria control by undermining artemisinin-based combination therapies (ACTs). Sparse surveillance obscures whether rising k13 ART-R prev…
  pubmed Young NW, Meier-Scherling CPG, Cuomo-Dannenburg G, Tollefson GA 等 2026 Jul 7 置信度 0.82
• Sex-related differences in skeletal relapse after bimaxillary orthognathic surgery: A retrospective case-control study.
  Postoperative skeletal relapse remains a significant challenge following orthognathic surgery. While several risk factors, such as the magnitude of surgical movements and high preoperative mandibular plane angle, have been identified, the influence of biologic…
  pubmed Vermeiren F, Alsharif U, Vercruysse H Jr, Nadjmi N 等 2026 Sep 置信度 0.82
• LAML-Pro: joint maximum likelihood inference of cell genotypes and cell lineage trees.
  Recent dynamic lineage tracing technologies use genome editing to induce heritable mutations, or edits, that accumulate across successive cell divisions. These edits are measured using single-cell sequencing or imaging, providing data to reconstruct cell linea…
  pubmed Chu G, Schmidt H, Raphael BJ 2026 Jul 1 置信度 0.82
• MOCDT: multi-cancer detection and tissue-of-origin classification via cfDNA multi-modal integration.
  Tumor-derived circulating tumor DNA (ctDNA) fragments present in blood provide rich molecular signals for identifying cancer and mapping its tissue of origin. However, leveraging these heterogeneous signals requires robust computational integration methods. Ex…
  pubmed Kim G, Rhee S, Lee Y, Jeong S 等 2026 Jul 1 置信度 0.82
• PU-GRAIL: residue-level graph learning for identifying protective bacterial antigens under positive-unlabeled supervision.
  The identification of protective antigens is fundamentally constrained by sparse annotations and pervasive label uncertainty in reverse vaccinology. Protective antigen-antibody interactions are mediated by a limited subset of surface-accessible residues that f…
  pubmed Jeon J, Jung S, Jung I, Kim K 等 2026 Jul 1 置信度 0.82
• ATTNSOM: learning cross-isoform attention for cytochrome P450 site-of-metabolism prediction.
  : Identifying metabolic sites where cytochrome P450 enzymes metabolize small-molecule drugs is essential for drug discovery. Although existing computational approaches have been proposed for site-of-metabolism prediction, they typically ignore cytochrome P450 …
  pubmed Kim H, Lee E, Chung S, Park J 等 2026 Jul 1 置信度 0.82
• Is Calcific Tendinitis a Risk Factor for Rotator Cuff Tears? A Retrospective Magnetic Resonance Imaging-Based Case-Control Study.
  The association between calcific tendinitis (CaT) and rotator cuff tears (RCTs) remains controversial, and it is unclear whether CaT represents a predisposing risk factor for tendon tears. This study aimed to investigate the relationship between CaT and RCTs u…
  pubmed Tonkaz G, Erkal D, Aksoy İ, Tonkaz M 等 2026 Apr 13 置信度 0.82
• An integrated toolkit for structure generation, optimization, and evaluation in spatially fractionated radiation therapy.
  Spatially fractionated radiation therapy (SFRT) planning requires three coordinated tasks: generation of high-dose sphere structures, position-aware optimization, and peak-valley dose ratio evaluation. In practice, clinicians and researchers address these task…
  pubmed Patel JK, Magliari A, Gill G, Wareing TA 等 2026 Jul 置信度 0.82
• Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.
  The transition from episodic clinical assessment to continuous physiological monitoring represents a transformative shift in biomedical engineering. This review comprehensively examines recent advancements in human-interfaced sensing systems, categorized into …
  pubmed Kim W, Kim Y, Yoo H, Lee EK 2026 Jul 7 置信度 0.82
• Probiogenomic analysis of functional potential and safety of L. plantarum 8p-a3 and DMC-S1 strains: in silico vs in vitro and in vivo data.
  The molecular basis of the beneficial effects and the causes of the negative effects of probiotics are not entirely clear. Clarifying these issues is important for understanding the biology and assessing the safety of the microbes. Omics technologies have open…
  pubmed Markelova M, Kostenko V, Aristova A, Nikolaeva M 等 2026 Aug 4 置信度 0.82
• Behavioral and structural drivers of HIV in men who have sex with men in Belize: a mixed-methods study.
  To estimate the prevalence of human immunodeficiency virus (HIV) in men who have sex with men (MSM) in Belize and identify behavioral and structural factors associated with infection.
  pubmed Oladeji O, Manzanero ML, Romero E, Baffoe P 2026 置信度 0.82
• Sex estimation from morphometry of lumbar vertebrae (L4-L5): A machine learning approach.
  Sex estimation is the first and most important step in establishing a reliable biological identity during the examination of skeletal remains. For sex estimation, the pelvis and cranial bones are primarily preferred. In cases where the pelvis bones are not ava…
  pubmed Ayturk BG, Keles A, Osmanoglu UO 2026 Jul 4 置信度 0.82
• Leafcutter Ant Farmers Prevent Loss of Edible Symbiotic Structures by Maintaining Allelic Diversity in Their Multinucleate Fungal Crop.
  Leafcutter ants farm the domesticated fungal cultivar Leucoagaricus gongylophorus in subterranean nests containing up to hundreds of discrete garden chambers. The fungal cultivar produces edible symbiotic structures called gongylidia (nutritious swollen hyphal…
  pubmed Rødsgaard-Jørgensen A, Leal-Dutra C, Kokkoris V, Shik JZ 2026 Jul 置信度 0.82