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• TRPC6 loss triggers mitochondrial dysfunction that drives white adipose tissue vulnerability to obesity and insulin resistance.
  Calcium signaling is essential for adipocyte function; however, the upstream Ca 2+ channels coordinating adipose metabolism remain poorly defined. Here, we identify TRPC6 as a Ca 2+ channel enriched in early adipocyte progenitors that orchestrate white adipose…
  pubmed Nguyen PA, Hwang KH, Tran DTT, Lee TS 等 2026 Jul 置信度 0.82
• Comparative efficacy of biologic agents for severe chronic rhinosinusitis with nasal polyps: Systematic review and network meta-analysis.
  Biologic therapies improve outcomes in severe chronic rhinosinusitis with nasal polyps (CRSwNP), but their comparative efficacy remains uncertain.
  pubmed Ouranos K, Michael M, Mylona EK, Mylonakis SC 等 2026 Jul 3 置信度 0.82
• Prediction of drug hypersensitivity by comprehensive modeling of HLA-peptidomes.
  Human leukocyte antigen (HLA)-B*57:01 associated with abacavir-induced hypersensitivity syndrome (ABC-HSS) is one of the most extensively studied immune-mediated drug hypersensitivity reactions (DHRs). The high odds ratio and strong predictive values of HLA-B*…
  pubmed Zhong Y, Lauschke VM, Wang Y, Zhou Y 2026 Jul 3 置信度 0.82
• Real-Time Smartphone Monitoring Assessments as a Cognitive Biomarker of Alzheimer Disease: Protocol for a Development Study.
  The diagnosis and monitoring of Alzheimer disease (AD) currently rely on clinician-administered, in-person, and cross-sectional pen-and-paper cognitive assessments. While clinically validated, these measures are time-intensive, infrequently administered, and l…
  pubmed McKenna M, Torous J, Rozenblit E, Flathers M 等 2026 Jul 3 置信度 0.82
• Mechanistic insights into acetylated histone recognition by the CECR2 bromodomain.
  Chromatin remodeling regulator CECR2 (cat eye syndrome chromosome region candidate 2) plays critical roles in neurulation, spermatogenesis, DNA damage response, and cancer metastasis, yet the structural determinants underlying its recognition of acetylated his…
  pubmed Chakraborty S, Roy A, Prusty S, Sahoo S 等 2026 Aug 5 置信度 0.82
• Research on Predicting the Efficacy of Immunotherapy for Non-small Cell Lung Cancer Based on CT Radiomics and Peripheral Blood Inflammatory Markers.
  IntroductionWe developed and validated predictive models based on CT radiomics and peripheral blood inflammatory markers to predict immunotherapy response in non-small cell lung cancer (NSCLC).MethodsThis retrospective study included 128 NSCLC patients receivi…
  pubmed Wen X, Li Y, Hu Y, Chen A 等 2026 Jan-Dec 置信度 0.82
• A Reporting Guideline for Observational Studies in Metabolomic Epidemiology: Explanation and Elaboration of the Strobe-MetEpi Checklist.
  Metabolomic epidemiology has expanded rapidly, but publications often lack sufficient detail for readers to assess study design, analytical methods, sources of bias, and the robustness and reproducibility of findings. Existing reporting recommendations in epid…
  pubmed Kelly RS, Reinke SN, Lorentzen G, Chatziioannou AC 等 2026 Jun 25 置信度 0.82
• Integrated surveillance resolves Darién paradox of Oropouche virus emergence in Panama's migration corridor.
  Oropouche virus (OROV) spread across the Americas in 2024, yet Panama's Darién migration corridor saw no outbreak until nearly a year after Brazil's January 2024 peak, raising two hypotheses: cryptic circulation masked by diagnostic gaps, or recent introd…
  pubmed Rodríguez X, Perez-Jimenez JG, Alexander LW, Lezcano-Coba C 等 2026 Jun 22 置信度 0.82
• Multiomics Mendelian Randomization Identifies Lactylation-Related Molecular Traits in Type 1 Diabetes.
  Lactylation is a posttranslational modification involved in cellular metabolic and immune processes. Although dysregulated lactate metabolism has been implicated in type 1 diabetes (T1D), the genetic relevance of lactylation-related molecular traits remains po…
  pubmed Ding Y, Gao S, Ying L, Tang J 等 2026 置信度 0.82
• A Wearable Earplug-Shaped Piezoresistive Sensor Based on Ear Canal Deformation for the Screening of Temporomandibular Joint Motion Abnormalities.
  Temporomandibular disorder (TMD), as a multifactorial oral disease, has long relied on diagnostic methods of clinical palpation and imaging. However, these approaches are highly subjective, costly, and invasive. Inspired by the principle of clinical palpation,…
  pubmed Liu S, Wang B, Li Y, Liu B 等 2026 Jul 24 置信度 0.82
• Preoperative CT and inflammatory index-based risk scores for predicting short-term recurrence following resection of pancreatic ductal adenocarcinoma.
  Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, with nearly half of resected patients relapsing within one year. Current National Comprehensive Cancer Network (NCCN) and American Joint Committee on Cancer (AJCC) staging systems inadequately r…
  pubmed Mansouri-Tehrani MM, Zamani F, Iraji H, Safarnezhad Tameshkel F 等 2026 Jul 1 置信度 0.82
• In-depth multimodal validation of (18)F-THK5351 for imaging monoamine oxidase-B-mediated reactive astrogliosis in Alzheimer's and related neurodegenerative diseases.
  18 F-THK5351, initially developed as a positron-emission tomography (PET) tracer for tau pathology, was later shown to display high affinity for monoamine oxidase-B (MAO-B), raising uncertainty about the biological origin of its brain signals in neurodegenerat…
  pubmed Chun H, Youn W, Lim H, Harada R 等 2026 Jul 置信度 0.82
• KASSPer: kinase active site structure prediction using protein and ligand language models and its application to virtual screening.
  Structure-based virtual screening (SBVS) is limited by the rigid-receptor assumption, which is particularly problematic for kinases that adopt multiple active-site conformations but are experimentally biased toward a single state. Although ensemble screening c…
  pubmed Jang W, Shin WH 2026 Jul 2 置信度 0.82
• Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
  Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disr…
  pubmed GBD 2023 TB HIV Collaborators 2026 Jul 1 置信度 0.82
• Use of advanced cardiovascular imaging in rheumatic immune-mediated inflammatory diseases.
  To evaluate the real-world use of advanced cardiovascular imaging in less common and rare rheumatic immune-mediated inflammatory diseases (IMIDs) and identify variation in practice to inform future studies and clinical guidelines.
  pubmed Gumber L, Meghji MA, Kakkar V, Sivasankaran K 等 2026 Jun 30 置信度 0.82
• Ontogenetic skull variation in a round-headed Trogonophidae amphisbaenian species with inferences on bite force.
  Amphisbaenia is a group of burrowing fossorial reptiles that uses their heads as the primary tool for digging. The shape of their skulls is influenced by the mechanical needs of the animal, such as digging and feeding. Four basic skull shapes are recognized: r…
  pubmed Hohl LSL, Sabino-Rodrigues MA, Machado AS, Lopes RT 等 2026 Jul 1 置信度 0.82
• Multi-center validation of a machine learning model for early detection of monoclonal immunoglobulin-related disorders using routine laboratory data.
  Monoclonal immunoglobulin (MIg)-related disorders are clonal plasma cell diseases defined by aberrant MIg overproduction, typically presenting with subtle, non-specific manifestations that lead to underrecognition in routine clinical practice, delayed diagnosi…
  pubmed Hu Y, Hao X, Li X, Tang H 等 2026 置信度 0.82
• DeepTaxa: a hybrid CNN-BERT framework for 16S rRNA taxonomic classification.
  Accurate species-level classification of prokaryotic 16S rRNA sequences remains difficult: existing tools rely on exact alignment, k-mer heuristics, or phylogenetic placement and are limited by incomplete reference databases. Deep learning approaches in microb…
  pubmed Salah R, AbdElaal KR, Ghonaim L, Awe OI 等 2026 置信度 0.82
• In silico-predicted B-cell epitopes for bovine brucellosis serodiagnosis: Preliminary analytical evaluation of synthetic peptide- and multi-epitope protein-based indirect ELISAs.
  Serological methods are valuable diagnostic tools for bovine brucellosis, a zoonotic infectious disease with a worldwide distribution. Currently employed diagnostic methods utilize crude bacterial extract or regions of LPS, a molecule that can exhibit cross-re…
  pubmed de Souza LDR, Souza MFS, Lima PA, Cirilo TM 等 2026 置信度 0.82
• A Prospective Head-to-Head Comparison of HER2-Targeted and 18 F-FDG PET/CT for Detecting Axillary Lymph Node Metastases Among Newly Diagnosed HER2-Positive and HER2-Low Breast Cancer.
  To compare HER2-targeted with ¹⁸F-FDG PET/CT for detecting axillary lymph node metastasis in patients with newly diagnosed HER2-positive or HER2-low breast cancer.
  pubmed Huang X, Guo X, Li B, Yang H 等 2026 Sep 1 置信度 0.82
• Computed tomography findings in 11,504 adult patients with traumatic brain injury: a large real-world cohort study with a S100B subgroup analysis.
  The aim of this study was to characterize acute cranial CT findings in a large cohort of adult patients with traumatic brain injury and to explore the diagnostic performance of S100B in a selected subgroup. The hypothesis was that most cranial CT scans in adul…
  pubmed Clar C, Puchwein P, Moshammer M, Sadoghi P 等 2026 Jun 30 置信度 0.82
• Evolutionary dynamics of Respiratory Syncytial Virus in pre-pandemic, pandemic, and post-pandemic periods in Houston, Texas, USA.
  Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants and poses significant risks to immuno-compromised individuals and the elderly. The COVID-19 pandemic disrupted typical RSV seasonality, leading to unus…
  pubmed Avadhanula V, Agustinho DP, Sahni LC, Surathu A 等 2026 Jun 17 置信度 0.82
• A three-tier stackelberg game-based hierarchical optimization framework for integrated electric vehicle battery swapping and charging systems.
  This paper proposes a three-tier Stackelberg game-based hierarchical optimization framework for integrated electric vehicle (EV) battery swapping stations (BSS) and charging point operator (CPO) systems. The framework models the strategic interactions among th…
  pubmed Kannan S, Anbazhagan G, Mariprasath T, Alkayid K 等 2026 Jun 27 置信度 0.82
• Understanding the role of environmental pollutants on preterm births in Puerto Rico: The PROTECT approach.
  Preterm birth (PTB) is a leading worldwide cause of morbidity and mortality among children less than five years old. In 2006, Puerto Rico reported a PTB rate of 19.9%, the highest in the United States that year. Health care factors did not explain the high rat…
  pubmed Cordero JF, Vélez CM, Rosario Z, Casey V 等 2026 Apr 置信度 0.82
• Molecular signature exploration of novel Pyrazolone-derived sulfonamides against colorectal Cancer: Synthesis, biological profiling and computational modeling.
  Colorectal cancer remains a major global health challenge, highlighting the need for effective and selective anticancer agents. In the present study, a series of pyrazolone-derived sulfonamide analogues (Keum and Giovannucci, 2019a, 2019b; Morgan et al., 2023;…
  pubmed Gao X, Li S, Ren X, Yan L 2026 Sep 15 置信度 0.82
• Intron location and sequence modulate gene expression in Yarrowia lipolytica.
  Introns are widespread among eukaryotic genomes. While intron-containing genes often show higher expression than genes lacking introns, the intron features influencing gene expression remain largely elusive. Here, we systematically characterize the intron land…
  pubmed Qi Q, Tomaz da Silva P, Vangalis V, Dockx S 等 2026 Jun 22 置信度 0.82
• Molecular profiling of coronary stent testenosis: A systematic review and functional analysis of implicated genes.
  Coronary stent restenosis occurs in approximately 5% of patients treated with drug-eluting stents (DES) and is associated with adverse clinical outcomes. Elucidating the genetic mechanisms underlying restenosis may support precision medicine approaches to impr…
  pubmed El Mansouri R, Habbal R, Dehbi H 2026 Jun 26 置信度 0.82
• Evaluating vectors for the design of a spillover-disrupting Lassa virus transmissible vaccine.
  Lassa fever is a viral zoonotic disease that sickens tens of thousands of people each year when it spills over from its rodent reservoir throughout West Africa. Despite the burden this persistent spillover places on public health, stopping it has proven to be …
  pubmed Nuismer SL, Remien CH, Ghersi B, Nichols J 等 2026 Jun 置信度 0.82
• Validation of Blood-Based Biomarkers After Mild Traumatic Brain Injury with GCS 15 in a Singapore Emergency Department: An Observational Study.
  Background and Objectives : Traumatic brain injury (TBI) affects millions of people worldwide. The Glasgow Coma Scale (GCS) is commonly used to characterize its severity. Head computed tomography (CT) is frequently the diagnostic imaging modality of choice. Re…
  pubmed Kuan WS, Yau YW, Lim DXY, Yeoh CK 等 2026 Jun 5 置信度 0.82
• Bioactive Coatings on Ti-Zr-Nb Alloy: Synthesis, Characterization and Implantology Potential.
  This research reports on the properties of oxide-ceramic coatings produced by plasma electrolytic oxidation in novel electrolyte solutions for implantology applications. A series of bioactive calcium-phosphate coatings was synthesized on medical-grade Ti-13Zr-…
  pubmed Kovalenko K, Sukhyi K, Fedak M, Rimar M 等 2026 Jun 11 置信度 0.82
• PXDN, TCF4 and TSPAN7 Are Differentially Expressed in B-Cell Acute Lymphoblastic Leukaemia: An Integrative Analysis.
  Background/Objectives: Acute lymphoblastic leukaemia (ALL) is a biologically heterogeneous disease in which transcriptional dysregulation contributes to disease onset and progression. Despite survival rates exceeding 90% in high-income countries, relapsed and …
  pubmed Primo P, Cecere F, Cianflone A, Mastrodonato F 等 2026 Jun 10 置信度 0.82
• Progress in the Application of Machine Learning in the Field of Single-Cell and Spatial Transcriptomics.
  The rapid evolution of transcriptome sequencing technologies has driven significant breakthroughs across the life sciences. The advent of single-cell RNA-sequencing (scRNA-seq) has enabled gene expression profiling at single-cell resolution, whereas spatial tr…
  pubmed Zhu Y, Hao Z, Zhu L, Shen L 等 2026 May 26 置信度 0.82
• In Silico Systems Biology Approach for Prioritization of Candidate Genes Linked to Lipid Metabolism in the Context of Cardiovascular Disease Susceptibility in a Serbian Cohort.
  The population of Serbia faces a significant burden from cardiovascular diseases (CVDs). This study aimed to computationally investigate genetic factors that contribute to the prevalence of these diseases by examining the possible involvement of common variant…
  pubmed Drljača T, Perović V, Veljković N, Gemović B 2026 Jun 12 置信度 0.82
• An Exploratory Transcriptomic Classification Model for Psoriasis Based on Apoptosis-Associated and Proliferation-Apoptosis-Coupled Genes Using Explainable Machine Learning.
  This study aimed to integrate apoptosis-associated and proliferation-apoptosis-coupled transcriptomic signatures with explainable machine learning to construct an exploratory molecular classification model for psoriasis. Transcriptomic datasets GSE30999 and GS…
  pubmed Liu X, Fu W, Li J, Jing M 等 2026 Jun 16 置信度 0.82
• Integrative Transcriptomics Uncovers IFN-β Signature and IFITM3 as Putative Molecular Mediator in MS.
  Neuroinflammation in multiple sclerosis (MS) is driven by the infiltration of myelin-reactive T cells into the central nervous system (CNS). Interferon-β (IFN-β) is one of the earliest disease-modifying treatments (DMTs) approved for MS and remains…
  pubmed Maglione A, Rosso R, Rolla S, Virgilio E 等 2026 Jun 12 置信度 0.82
• Small Molecule Liver X Receptor Modulator GAC0001E5 Targets Mechanisms of Endocrine Resistance in Estrogen Receptor-Positive Breast Cancer Cells.
  Endocrine therapy is an effective and common treatment strategy for estrogen receptor (ER)-positive breast cancers. However, the development of endocrine resistance, through genetic mutations and epigenetic alterations, in about 40% of treated patients remains…
  pubmed Basu S, Premaratne A, Widmann S, Olaleye EA 等 2026 Jun 11 置信度 0.82
• Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived Biomarkers.
  Sensitive skin is characterized by hypersensitivity to normal stimuli, and objective diagnostic tools and treatments are still limited. Currently, cosmetics for sensitive skin are developed through the exclusion of known irritants rather than investigation int…
  pubmed Kim SH, Kim JH, Shin JM, Choi YM 等 2026 Jun 9 置信度 0.82
• Biological Interactions in Rat Tibial Osteogenesis: Micro-CT, Histomorphometric, and Histological Analyses of Bioglass, Fibrin Biopolymer, and Photobiomodulation.
  The study evaluated bone repair in tibial defects of Wistar rats treated with 45S5 bioactive glass, either alone or combined with lyophilized heterologous fibrin biopolymer (HFB) and/or photobiomodulation therapy (PBM). Thirty-five animals were randomly assign…
  pubmed Bueno LMM, Dias LC, Bighetti ACC, Dos Santos CPC 等 2026 May 26 置信度 0.82
• Analysis of Pericoronary Adipose Tissue Attenuation in Patients with Type 2 Diabetes Mellitus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: A Propensity-Score-Matched Observational Study.
  Background: In patients with type 2 diabetes mellitus (T2DM), angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are first-line antihypertensive treatments with important cardiovascular benefits, but their impacts on cor…
  pubmed Wu B, Joh H, Nieman K, Sandoval R 2026 Jun 2 置信度 0.82
• Whole metagenome sequencing: not deep enough for complete microbial function recovery.
  Whole metagenome shotgun sequencing (WMS) is widely used to profile microbial function. However, technical variability in sequencing and analysis often obscures true biological patterns. Large-scale studies are particularly susceptible to batch effects, such a…
  pubmed Liu J, Coker MO, Osazuwa-Peters N, Peter O 等 2026 Jun 25 置信度 0.82
• Adaptive Multi-Scale Fusion Enhanced RT-DETR for Efficient Cyanobacteria Detection in Microscopic Images.
  Accurate and efficient detection of cyanobacteria in microscopic images is important for automated water-quality monitoring, but remains challenging because of complex aquatic backgrounds, large scale variation, and uneven sample quality. This study proposes a…
  pubmed Li J, Zheng S, Chen Y, Luo K 2026 Jun 20 置信度 0.82
• Modeling, Analysis, and Optimal Control of Leukemic Cell Population Dynamics Under Therapy.
  Building upon the ODE model describing the dynamics of healthy and leukemic cells introduced in Kumar et al. (2024); Stiehl and Marciniak-Czochra (2012), we propose an extended framework that incorporates a control variable representing the effects of chemothe…
  pubmed Mazel P, Grognard F, Stiehl T, Rapaport A 等 2026 Jun 24 置信度 0.82
• CT-Assessed Sarcopenia Combined with Laboratory Inflammatory Markers for Outcome Prediction in Critically Ill, Pulmonary, and Geriatric Patients: A Systematic Review and Meta-Analysis.
  Sarcopenia, assessed via computed tomography (CT), is an emerging prognostic tool in critically ill, pulmonary, and geriatric patients. Laboratory inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil-to-lymphocyte ratio (…
  pubmed Elgazzar YA, Abdelrazek M, Ghozzy OAM, Mashhour K 等 2026 Jul-Aug 置信度 0.82
• Blood-based biomarkers GFAP/UCH-L1 for the diagnosis of mild traumatic brain injury (mTBI): a single-center implementation experience.
  Mild traumatic brain injuries (mTBI) affect millions of people worldwide every year as one of the most common clinical presentations in the emergency department. Diagnosis is mainly based on clinical criteria and computed tomography scans. The use of computed …
  pubmed Maegele M, Breidenbach L, Kaufmann J, Keles Y 等 2026 Jun 24 置信度 0.82
• Integrated pan-cancer multi-omics profiling and experimental validation identify LSM12 as a prognostic biomarker and candidate therapeutic target in human cancers.
  RNA metabolism regulators remain insufficiently characterized across tumor types, despite the substantial expansion of multi-omics datasets. LSM12, a member of the Like-Sm (LSM) protein family involved in RNA processing, has not been systematically evaluated i…
  pubmed Eldeen MA, Refaat AM, Ahmed HEM, Hassan HM 等 2026 Jun 23 置信度 0.82
• Benchmarking DNA barcode decoding strategies under high error rates.
  DNA barcoding enables multiplexed identification of biomolecules in pooled sequencing experiments, with broad applications including spatial transcriptomics. Photolithographic synthesis of high-density barcode arrays achieves library sizes exceeding [Formula: …
  pubmed Poma-Soto F, Van Droogenbroeck H, Soulliaert B, Giridhar M 等 2026 Jun 23 置信度 0.82
• Diagnostic accuracy of (18)F-FDG PET-CT scores in distinguishing polymyalgia rheumatica from other inflammatory rheumatic diseases: a multicentre retrospective study (RHUMATEP).
  To evaluate the diagnostic accuracy of 18 F-FDG PET-CT-based scores to differentiate polymyalgia rheumatica (PMR) from other inflammatory rheumatic diseases.
  pubmed Quéré C, Devauchelle-Pensec V, Thuillier P, Besson F 等 2026 Sep 置信度 0.82
• Frequency-domain multi-scale hybrid attention for pathological image classification.
  Pathological image classification is critical for early cancer diagnosis and precise subtyping. However, pathological images exhibit significant heterogeneity and complex textures. Existing methods often fail to fully exploit local details, while frequency-dom…
  pubmed Zhang Y, Li J, Wang Q, Zhang L 等 2026 Jun 23 置信度 0.82
• From the Laboratory to the Field: Assessing the Usability of the NTDscope in the Tropical Rainforest Region of Gabon.
  In regions where Loa loa is coendemic with lymphatic filariasis and onchocerciasis, mass drug administration of ivermectin has posed a risk for serious adverse reactions in individuals with high microfilarial loads. To overcome this problem, easy-to-use point-…
  pubmed Zoleko Manego R, Endamne LR, Pahl V, Díaz de León Derby M 等 2026 Aug 5 置信度 0.82
• The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.
  The ancient pyruvate dehydrogenase complex (PDHc) performs the "link reaction" of cellular respiration-a discovery from the 1930s that was central in the award of the 1953 Nobel Prize in Physiology and Medicine to Krebs and Lipmann. Fast forward to 2024, PDHc …
  pubmed Träger TK, Kyrilis FL, Kafetzopoulos G, Tüting C 等 2026 置信度 0.82
• Electrocatalytic Water Oxidation by a Heterogenized Co (III)-Aminophenol Complex: Structure-Activity Relationship and DFT Mechanistic Insights.
  The advancement of efficient and cost-effective molecular electrocatalysts is essential in the quest for sustainable energy solutions. The design and synthesis of a new mononuclear cobalt (III) complex with a redox-active aminophenol ligand have been presented…
  pubmed Sarkar D, Sehrawat N, Yadav S, Palatasingh S 等 2026 Jun 置信度 0.82
• Navigating the Evolution of Urothelial Carcinoma Treatment: From Chemotherapy to Immunotherapy.
  The urothelial carcinoma (UC) trial landscape has expanded over two decades, alongside a shift from chemotherapy to immunotherapy and targeted approaches. We characterized temporal patterns in trial phase, interventions, sponsorship, geographic footprint, and …
  pubmed Li B, Yang Z, Pei Y, Wang Y 等 2026 Jun 置信度 0.82
• Traditional phytopharmaceutical practices and integrative healthcare perspectives among herbal practitioners: a cross-sectional analysis in Tigray, Ethiopia.
  Traditional medicine remains a crucial component of primary healthcare in Ethiopia. This study assessed phytopharmaceutical practices and integrative health perspectives among traditional herbal practitioners in Tigray, Ethiopia. A community-based mixed-method…
  pubmed Desta YT, Tsegay TG, Abraha HK 2026 Jun 23 置信度 0.82
• Multimodal Data Approaches for Examining the 2024-2025 Highly Pathogenic Avian Influenza Outbreak in the United States: Descriptive Study.
  Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b, a globally predominant strain, was introduced into poultry in the United States in 2022 via spillover from wild birds, and has since been regularly reported, posing ongoing risks to animal and hu…
  pubmed Sopko J, Han AR, Powers J, Sauer JA 等 2026 Jun 22 置信度 0.82
• Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease.
  As of now, current studies have confirmed that circadian rhythm genes (CRGs) can modulate the onset and development of metabolic dysfunction-associated fatty liver disease (MAFLD). Leveraging computational biology methodologies, systematic and thorough investi…
  pubmed Luo J, Ma X, Wang Q, Zhang R 等 2026 Jun 22 置信度 0.82
• Three Decades of Prosthodontic Oral Rehabilitation: A Bibliometric Analysis of Materials, Implants, and Digital Workflows.
  Over the past three decades, prosthodontic research has expanded from material- and implant-focused rehabilitation toward increasingly digital and function-oriented approaches in oral rehabilitation. Understanding how these shifts align with functional, biolog…
  pubmed Ho YS, Kumar A, Christidis N, Grigoriadis A 2026 置信度 0.82
• Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.
  Thyroid hormones play critical roles in regulating bone turnover and maintaining bone mass. However, the relationship among thyroid hormones, their sensitivity indices, bone mineral density (BMD) and fracture risk remained unclear in the Chinese osteoporotic p…
  pubmed Meicen Z, Wei D, Yanai W, Lili H 等 2026 置信度 0.82
• Trap spaces as labelled ideals of SCC posets: A structural-functional theory of reachability in asynchronous boolean networks.
  Boolean networks provide a qualitative framework for modelling regulatory systems when kinetic parameters are unavailable, with cellular phenotypes represented as attractors of the induced dynamics [J. D. Schwab et al. , Concepts in Boolean netw…
  pubmed Yizengaw BY 2026 Jun 置信度 0.82
• Biology-informed risk stratification of glioblastoma by integrating MRI-based intratumoral heterogeneity with clinical features: a multicenter validation study.
  Refined risk stratification before randomization is clinically important for reducing prognostic imbalance across study arms when evaluating novel therapies for glioblastoma. However, current artificial intelligence-assisted prognostic models are often limited…
  pubmed Zhang J, Guo H, Ma X, Zhong Y 等 2026 Jun 21 置信度 0.82
• The potential role of dynein heavy chain genes in the pathophysiology of undescended testis.
  Failures of testicular descent may result in the condition known as an undescended testis (UDT). While mechanical and hormonal causes have been researched quite extensively, not much is known about the underlying genetics. Developmental processes dependent on …
  pubmed Kılıç S, Turkgenc B, Baltrak YA, Güler GC 等 2026 Jun 21 置信度 0.82
• BPTF is essential for vaccine-induced germinal center B cell responses.
  Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B…
  pubmed Sturtz AJ, Evavold BK, Heidari Rarani Z, Alsoussi WB 等 2026 Jun 7 置信度 0.82
• PERK orchestrates an endoplasmic reticulum stress alternative splicing program via CLK1/SRSF1.
  The unfolded protein response (UPR) is a critical adaptive program triggered upon cellular stresses that profoundly reshapes the transcriptome and translatome. In the very first minutes of cellular stress, translation blockage, RNA decay and RNA granules forma…
  pubmed Philippe C, Burke S, Carrasco-Leon A, Martisova A 等 2026 Jun 19 置信度 0.82
• Multifactorial strategies for the prevention of the risks of ulceration in patients affected by diabetic foot: a no-profit, multicentre, clinical trial protocol.
  Diabetes mellitus is a global epidemic affecting hundreds of millions of people worldwide. The diabetic foot is among the most serious complications, and it is estimated that between 15 and 25% of patients with diabetes mellitus develop ulcers during their lif…
  pubmed Leardini A, Pagotto U, Dalla Paola L, Leopardi MP 等 2026 Jun 19 置信度 0.82
• Simulating interventions to prevent gastro-intestinal transmission of Clostridioides difficile and antimicrobial-resistant bacteria in healthcare settings: a model calibration study.
  Hospital-acquired infections caused by pathogens such as Clostridioides difficile and antimicrobial-resistant bacteria are a major burden to healthcare systems. Infection prevention and control (IPC) measures are used to limit transmission, but quantifying the…
  pubmed Gerada A, Zhong Y, Brookefield C, Howard A 等 2026 Jun 19 置信度 0.82
• Engagement Trends in Online Vaccine Content: Longitudinal YouTube Study.
  YouTube is the primary global video platform, hosting both authoritative health information and vaccine-skeptic viewpoints. However, engagement dynamics remain poorly understood.
  pubmed Tizzani M, Mejova Y 2026 Jun 19 置信度 0.82
• Porcine MutBERT: a family of lightweight genomic foundation models for functional element prediction in pigs.
  The pig (Sus scrofa) is both an economically important livestock species and a valuable biomedical model . Its genome bears regulatory features shaped by domestication and selection that are often poorly captured by genomic language models (gLMs) trained on hu…
  pubmed Long W, Zhou R, Wei W, Zhang X 等 2026 May 4 置信度 0.82
• Material damage to multielectrode arrays after electrolytic lesioning is insignificant.
  The quality of stable long-term recordings from chronically implanted electrode arrays is essential for experimental neuroscience and brain-computer interfaces. This work uses scanning electron microscopy (SEM) to image and analyze eight 96-channel Utah arrays…
  pubmed Tor A, Clarke SE, Bray IE, Nuyujukian P 等 2026 Jun 19 置信度 0.82
• Management of suspicious nodules in lung cancer screening - a narrative review of monitoring strategies based on nodule features and further needs.
  Low-dose computed tomography screening plays a pivotal role in early lung cancer detection. This narrative review aims to evaluate nodule characteristics, especially volume doubling time (VDT), and their relevance to lung cancer suspicion, staging, and clinica…
  pubmed Anghel R, Moga VL, Folea AR, Zgură AF 等 2026 置信度 0.82
• Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High-Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non-Invasive Diabetes Monitoring.
  Elevated methylglyoxal (MG) levels contribute to diabetes-related complications through accelerated formation of advanced glycation end products, highlighting the need for sensitive, portable, and non-invasive monitoring strategies. Here, we report a gold-carb…
  pubmed Soshi AA, Ali MY, Pazuki D, Howlader MMR 2026 Jul 置信度 0.82
• Deep Learning vs. Traditional Machine Learning in the Diagnosis of Cutaneous Drug Eruptions: A Comparative Study with Explainable AI on Whole-Slide Images.
  Histopathological diagnosis of cutaneous drug eruptions (CDEs) presents a challenge in dermatopathology due to morphological overlap and high inter-observer variability. This retrospective study systematically compares the diagnostic performance of modern conv…
  pubmed Türkmen Dedeoğlu A, Yanık H, Uysal E, Fikir G 等 2026 Jun 18 置信度 0.82
• Spatial and temporal prediction of Aedes aegypti populations with atmospheric and urban forms dependence.
  Accurately predicting mosquito population dynamics in cities requires models that couple climatic sensitivity with urban spatial heterogeneity. We developed a spatially explicit, climate-driven framework that integrates satellite imagery, field observations, a…
  pubmed Lugão PHG, da Silva MR, Cascelli R, Chapiro G 2026 Jun 23 置信度 0.82
• Review Article | Diagnosis and Early Detection of Lung Cancer: Present and Future Approaches.
  Lung cancer is the leading cause of cancer deaths worldwide, with most cases found late. This review summarizes evidence on lung cancer diagnostics, highlights findings from important screening trials, and discusses new technologies shaping future approaches. …
  pubmed Fadelelmoula T 2026 May 置信度 0.82
• Pyrithione: A Privileged Structure with the Essential Pharmacophore for Inhibiting Zinc Metalloenzymes.
  Zinc Pyrithione is a naturally occurring zinc complex well-known as an antifungal agent, used in the treatment of dandruff and other scalp-related diseases for more than half a century. Pyrithione has been exploited as a potential antimicrobial and anticancer …
  pubmed Shin WS, Zafar S, Kuebler TS, Dodda VR 等 2026 Jun 16 置信度 0.82
• MiRInter-Trans: a transformer-based framework for microRNA interaction prediction.
  The accurate prediction of microRNA (miRNA) interactions represents a significant challenge in computational biology, with far-reaching implications for understanding gene regulatory networks and developing RNA-based therapeutics. We present miRInter-Trans , a…
  pubmed Nicolini M, Stacchietti F, Molina FJ, Cano C 等 2026 置信度 0.82
• Laser speckle imaging for biofilm viability assessment: a noninvasive alternative to the MTT assay.
  Accurate measurement of cell viability in biofilms is critical in biology and medicine. We propose two laser speckle-based methods to assess the viability of Candida tropicalis biofilms. Time-varying speckle images were processed using temporal correlation ana…
  pubmed Loaiza-Toscuento DI, Perez-Corona CE, Spezzia-Mazzocco T, Peregrina-Barreto H 等 2026 Jun 1 置信度 0.82
• Identification of Quinoline Tethered Thiadiazole/Thiazole Derivatives as Potent Tyrosinase Inhibitors With Promising Anti-Toxoplasma gondii Agents: Design, Synthesis, and Computational Analysis.
  Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, remains a serious global health concern, largely because current treatments with sulfonamides and pyrimethamine are toxic and increasingly ineffective due to rising drug resistance. In response…
  pubmed Sabt A, Chyb M, Srour AM, Bekier A 等 2026 Aug 置信度 0.82
• Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024.
  Clinical guidelines for type 2 diabetes (T2D) provide population-level recommendations, but real-world treatment patterns evolve dynamically and vary across patients. Understanding longitudinal prescribing trajectories may reveal heterogeneity in care not capt…
  pubmed Lux TS, Lee D, Phillips JM, Facelli JC 等 2026 Sep 置信度 0.82
• Durability and elongation of artificial chords in pediatric mitral valve repair: A comprehensive echocardiographic analysis.
  To evaluate the long-term remodeling, biological adaptation, and clinical outcomes of expanded polytetrafluoroethylene (ePTFE) artificial chords (AC) used for pediatric mitral valve (MV) repair through comprehensive echocardiographic analysis.
  pubmed Fournier E, Deng MX, Provost B, Weiss J 等 2026 Jun 17 置信度 0.82
• First-in-human evaluation of [(18)F]-AlF-NOTA-neurotensin for NTSR1-targeted imaging of prostate cancer: a head-to-head comparison with [(68)Ga]Ga-PSMA-617.
  Neurotensin receptor-1 (NTSR1) is a promising target for prostate cancer imaging. This study evaluates the first-in-human NTSR1-directed radiotracer [ 18 F]-AlF-NOTA-neurotensin and compares it with [ 68 Ga]Ga-PSMA-617.
  pubmed He J, Wang Y, Tang W, Gao X 等 2026 Dec 置信度 0.82
• Adaptation and exploratory factor analysis of a PCOS-specific HRQoL questionnaire in a South Indian population.
  Polycystic Ovary Syndrome (PCOS) is a multifaceted disorder with physical, emotional, and social implications. Culturally adapted tools for assessing Health-Related Quality of Life (HRQoL) in Indian women, particularly those under 18 and over 45 years of age, …
  pubmed Washington A, Shenoy HT, B P, Kumar R 2026 Jun 16 置信度 0.82
• Bioinformatic identification of CD8+ T cell activation mediated by key genes in fecal microbiota transplantation for irritable bowel syndrome.
  The effect of fecal microbiota transplantation (FMT) in treating irritable bowel syndrome (IBS) may be attributed to the modulation of CD8 + T cells. This study aims to identify FMT-mediated key genes to explore the underlying mechanism.
  pubmed Fei Y, Gao MY, Qiao N, Hu J 等 2026 置信度 0.82
• Thirty-year transition of disease burden attributed to low bone mineral density: A disaggregated analysis of Global Patterns and China's Epidemiological Profile (1990-2021).
  This study aims to compare the disease burden of low bone mineral density (LBMD) between China and global populations from 1990 to 2021 and quantify the associations of sex, age, and socio-demographic index with disability-adjusted life years (DALYs). A second…
  pubmed Ge L, Qi Z, Liu Y, Shi L 等 2026 Jun 12 置信度 0.82
• Corrigendum to <'Co-localization and co-expression of Olfml3 with Iba1 in brain of mice'> <[Journal of Neuroimmunology, 394 (2024) 1-12/578411]>.
  pubmed Yadav H, Bakshi A, Anamika, Singh V 等 2026 Sep 置信度 0.82
• Nuclear Enlargement as a Histological Hallmark of Skeletal Muscle Aging, Revealed by Deep Learning-Driven Analysis and Validated in Inflammatory Myopathies.
  Aging reshapes the architecture of human skeletal muscle, yet objective tissue-level markers that capture this process remain limited. We combined large-scale histology with deep learning to identify reproducible features of muscle aging and to test their biol…
  pubmed Dao T, Nguyen TT, Hoang GM, Park J 等 2026 Jun 置信度 0.82
• Immunoinformatic based Development of a Multi-Epitope Precision Vaccine Targeting Glycoprotein and RdRp of Oropouche Virus: An Innovative Approach to Counter Emerging Public Health Threats.
  To design high immunogenic vaccine against the Oropouche virus (OROV). The OROV is a neglected arbovirus endemic to Central and South America, causes oropouche fever, which can progress to severe complications such as meningitis and hemorrhagic symptoms.
  pubmed Alissa M, Suleman M 2026 Jul 置信度 0.82
• Influenza Vaccination Among Individuals With Type 1 Diabetes in Denmark: Coverage, Persistence, and Determinants, 2015-2022.
  To investigate influenza vaccination coverage (IVC) and persistence with annual influenza vaccination among individuals with type 1 diabetes in Denmark and to identify clinical, demographic, and socioeconomic factors associated with vaccination status.
  pubmed Karunakaran V, Pedersen IB, Hjelholt A, Kjølby M 等 2026 Sep 置信度 0.82
• Twenty years of the Mexican Proteomics Society.
  The Mexican Proteomics Society (MPS), founded in 2005, is the earliest proteomics society in Latin America. It is a non-profit organization comprising academics and professionals committed to advancing research in proteomics, metabolomics, and mass spectrometr…
  pubmed Encarnación-Guevara S, Teran LM, Huerta-Ocampo JÁ 2026 Aug 15 置信度 0.82
• Real-world patient-reported symptomatic adverse events and concordance with physician assessments after CAR T-cell therapy in patients with aggressive B-cell lymphomas: a prospective study.
  Chimeric antigen receptor (CAR) T cells have shown considerable promise in treating patients with haematological malignancies. We aimed to investigate short-term patient-reported symptomatic adverse events in patients with aggressive B-cell lymphomas treated w…
  pubmed Efficace F, Zinzani PL, Bonifazi F, Cutini I 等 2026 Jul 置信度 0.82
• Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles.
  The ionizable lipid in lipid nanoparticles can be replaced with ionizable drugs to encapsulate small interfering RNA (siRNA) and allow intracellular codelivery. We wondered whether we could develop a predictive model to aid in formulation design. A small-scale…
  pubmed Slaughter KV, Dang M, Donders EN, Cheng AH 等 2026 Jun 12 置信度 0.82
• Ready-to-load MHC-I nanoparticles for high-throughput T cell screening studies.
  MHC-I proteins present epitopic peptides to CD8 + T cells to elicit multifaceted adaptive immune responses. The affinity and avidity of interactions between peptide-MHC molecules and their cognate T cell receptors (TCRs) are fundamental parameters that contrib…
  pubmed Phan HAT, Eom S, Hwang D, Young MC 等 2026 Jun 12 置信度 0.82
• Report from the BV-BRC, CDC, NCBI, and NIAID Viral Sub-Species Classification Workshop.
  The Viral Sub-Species Classification Workshop, held from 8 to 10 April 2024 at the National Institute of Allergy and Infectious Diseases (NIAID), addressed scientific and technological challenges in the classification of viruses below the level of species. Co-…
  pubmed Lefkowitz EJ, Rutvisuttinunt W, Brister JR, Capria A 等 2026 Jul 21 置信度 0.82
• Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates.
  The SARS-CoV-2 papain-like protease (PL pro ) and the main protease (M pro ) catalyze hydrolysis of the viral polyproteins pp1a/1ab into functional nonstructural proteins. PL pro and M pro are medicinal chemistry targets, with M pro inhibitors being used for C…
  pubmed Sharma S, Wing PAC, Treyde W, Basak S 等 2026 Jun 12 置信度 0.82
• Temporal trends and estimated lifetime attributable radiation risk of preoperative planning computed tomography for primary shoulder arthroplasty.
  Advantages of preoperative planning computed tomography (CT) scans for shoulder arthroplasty (SA) are known; however, risks of ionizing radiation exposure remain unknown. We retrospectively reviewed institutional trends in utilization and estimated radiation r…
  pubmed Kalva SR, Fucich D, Perry AJ, Lezak B 等 2026 Jun 9 置信度 0.82
• CONTRA-IL6: an interpretable hybrid convolutional neural network and Transformer framework for accurate prediction of interleukin-6-inducing peptides using protein language models.
  Interleukin-6 (IL-6) is a key immunomodulatory cytokine implicated in diverse physiological processes and pathological conditions, including autoimmune diseases, cancers, and cytokine storms. Immunogenic peptides capable of inducing IL-6 expression are key mod…
  pubmed Tran DT, Pham NT, Lee G, Basith S 等 2026 May 4 置信度 0.82
• Nutritional Composition, Micronutrient Fortification, and Processing Level of Plant-Based Yogurt Alternatives Available in Major Polish Retail Chains: A Retail Audit in Poznań, Poland.
  Background : The market for plant-based yogurt alternatives has rapidly expanded, reflecting the growing popularity of plant-based diets. However, their nutritional profiles and micronutrient fortification often differ substantially from those of traditional d…
  pubmed Kręgielska-Narożna M, Pastusiak-Zgolińska K, Mieczyńska A, Seraszek-Jaros A 等 2026 May 28 置信度 0.82
• Edge-Hosted LLM-Assisted NICU Discharge Summary Generation: Field-Level Evaluation Using a Clinician-Defined Rubric.
  Objective : To develop and evaluate an edge-hosted Large Language Model (LLM)-assisted system for automated Neonatal Intensive Care Unit (NICU) discharge summary generation using an evidence-grounded, field-level evaluation framework. Methods : This implementa…
  pubmed Singh H, Kaur R, Saluja S, Cho SJ 等 2026 May 25 置信度 0.82
• Deep learning-based prediction of gene expression from histopathology identifies NR5A1 as a candidate biomarker and druggable target in high-grade serous ovarian carcinoma.
  High-grade serous ovarian cancer (HGSOC) is the most lethal ovarian cancer subtype, responsible for ~&#x2009;70% of ovarian cancer-related deaths and marked by late-stage diagnosis and frequent platinum resistance. Although transcriptomic profiling enables mol…
  pubmed Lingasamy P, Ostrowska-Leśko M, Tsakalis P, Patel N 等 2026 Jun 11 置信度 0.82
• Proof-of-concept study: longitudinal immune biomarker signatures in treatment-naïve IgG4-related disease.
  Immunoglobulin G4-related disease (IgG4-RD) is a chronic, systemic, immune-mediated fibroinflammatory disorder characterized by heterogeneous organ involvement and variable clinical expression. Reliable biomarkers are needed to quantify inflammatory activity, …
  pubmed Lopez-Gomez M, Moya-Alvarado P, Park HS, Leyva TF 等 2026 Jun 11 置信度 0.82
• Modelling human skin morphology and simulating transdermal transport of 50 chemicals.
  A mathematical model was developed to investigate the transdermal transport of 50 chemicals across human skin. The model incorporates key skin properties and physicochemical parameters. Simulations were performed using experimentally determined partition and d…
  pubmed Tesfamarian M, Nägel A, Heisig M, Wittum G 2026 Sep 置信度 0.82
• Mapping the landscape of individual-based models for respiratory pathogen transmission in the pandemic and post-pandemic era (2020-2024): A systematic review.
  Individual-based models (IBMs) provide a mechanistic framework in which population-level outcomes emerge from interactions between individuals. We conducted a systematic review on IBMs for respiratory pathogens published in 2020-2024. We identified 855 eligibl…
  pubmed Mhade S, Bhosekar U, Hill MD, Sinclair S 等 2026 Jun 6 置信度 0.82