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• Generalise or Memorise? Benchmarking Ligand-Conditioned Protein Generation from Sequence-Only Data
  Proteins can bind small molecules with high specificity. However, designing proteins that bind userdefined ligands remains a challenge, typically relying on structural information and costly experimental iteration. While protein language models (pLMs) have sho…
  preprints 2026 置信度 0.74
• Statistical thermodynamics based design principles into the temperature induced fold switching of a metamorphic protein
  Fold-switching metamorphic protein sequences defy the classical “one sequence – one fold” paradigm. The ability of metamorphic proteins to reversibly switch between distinct folds make them attractive de novo protein engineering candidates since they can funct…
  preprints 2025 置信度 0.74
• Computing the Dissociation Constant from Molecular Dynamics Simulations with Corrections for the Large Pressure Fluctuations—Aquaglyceroporins Have High Affinity for Their Substrate Glycerol
  In this article, we consider the inevitable large fluctuations of pressure in typical molecular dynamics (MD) simulations of ligand-protein binding problems. In simulations under the constant pressure of one bar, the pressure artifactually fluctuates over the …
  preprints 2025 置信度 0.74
• Systematic non-natural base-pairs for strand displacement circuits in complex environments
  Nucleic acid strand displacement (SD) circuits have enabled impressive realizations of molecular computing in vitro , but operating them in contention with competing reaction pathways can cause signal leak and circuit failure. Further, operating SD circuits in…
  preprints 2025 置信度 0.74
• THz-induced phonon mode mixing and collective dynamics in a polar nanolattice
  Abstract Manipulating phonons through symmetry is a fundamental approach to alter the dynamic responses of materials. Most often new phases are sought through control of the unit-cell (e.g. via strain, doping, light, etc.). By comparison, there is vast potenti…
  preprints 2026 置信度 0.74
• The Evolution and Impact of Artificial Intelligence in Chemistry
  The revolutionary field of artificial intelligence (AI) has affected all aspects of our lives, including the field of chemistry. The impact of AI has been felt even more strongly in recent years, as new powerful computational tools have emerged. This review lo…
  preprints 2025 置信度 0.74
• Ground State Energy of He molecule Using a Four-Qubit Photonic Processor with the Variational Quantum Eigensolver
  Abstract To understand the properties and interactions of materials, and determining the ground state energies is one of the important challenges in quantum chemistry, materials science, and quantum mechanics, where quantum computing can play an important role…
  preprints 2025 置信度 0.74
• Bayesian multi-state multi-condition modeling of a protein structure based on X-ray crystallography data
  1 An atomic structure model of a protein can be computed from a diffraction pattern of its crystal. While most crystallographic studies produce a single set of atomic coordinates, the billions of protein molecules in a crystal sample many conformational modes …
  preprints 2025 置信度 0.74
• Hybrid Molecular-Electronic Computing Systems and Their Perspectives in Real-Time Medical Diagnosis and Treatment
  Advantages in CMOS MOSFET-based electronics served as a basis for modern ubiquitous computerization. At the same time, theoretical and practical development in material science, analytical chemistry and molecular biology opened the possibility of applying Bool…
  preprints 2025 置信度 0.74
• A Course-Undergraduate Research Experience (CURE) to explore the effect of structural variants on gene expression in <i>C. elegans</i> balancers
  Bioinformatics, a discipline at the crossroads of Biology and Computational Sciences, also referred to as Computational Biology, is nowadays widely spread in research programs. However, implementing any Bioinformatics projects requires the ability to comprehen…
  preprints 2026 置信度 0.74
• Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra
  ABSTRACT In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess the functional properties of sarcomeres at the nanoscale level i…
  preprints 2025 置信度 0.74
• Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase
  ABSTRACT Iterative polyketide synthases (iPKSs) rely on communication between acyl carrier protein (ACP) and acyltransferase (AT) domains to ensure efficient delivery of starter and extender substrates during biosynthesis. However, the molecular determinants g…
  preprints 2025 置信度 0.74
• phase2: Full-State Vector Simulation of Quantum Time Evolution at Scale
  Abstract Large-scale classical simulation of quantum computers is crucial for benchmarking quantum algorithms, establishing boundaries of quantum advantage and exploring heuristic quantum algorithms. We present a full-state vector simulation algorithm and soft…
  preprints 2025 置信度 0.74
• Molecular Crystal Memristor
  Abstract The emergence of memristors offers a revolutionary solution for achieving in-memory computing at the hardware level. However, existing memristors suffer from the inherent channel materials damage during cyclical resistive switching, rendering excessiv…
  preprints 2025 置信度 0.74
• Using Time Dependent Rate Analysis to Evaluate the Quality of Machine Learned Reaction Coordinates for Biasing and Computing Kinetics
  Having an accurate reaction coordinate (RC) is essential for reliable kinetic characterization of molecular processes, but there are few quantitative metrics to evaluate RC quality. In this study, we consider the dimensionless γ metric from the Exponential Ave…
  preprints 2025 置信度 0.74
• Selection for folding stability predicts observed covariation between protein positions in the PDB
  Abstract We present the Stability constrained model of protein evolution (SCPE) in the pairwise approximation. This model enforces protein folding stability, both against unfolding and against misfolding, which we predict with a statistical physics model based…
  preprints 2026 置信度 0.74
• Chemical Modification-Regulated Excited-State Dynamics and Charge Separation in TPA-C60 Donor-Acceptor Systems: A Nonadiabatic Molecular Dynamics Study.
  Understanding and regulating photoinduced charge-transfer dynamics in donor-acceptor (D-A) systems are crucial for the development of high-performance organic solar cells (OSCs). In this work, the excited-state properties and nonadiabatic dynamics of four chem…
  europepmc 2026 置信度 0.80
• Dynamic Self-Modification of γ-Al2O3 Driven by Alkaline-Metal Promotion and Carbocation-Mediated β-H Transfer for Efficient α-Olefin Synthesis.
  The surface acidity of solid acids─a key determinant of their catalytic performance─is considered as an intrinsic nature, generally modulated via precursor and synthesis chemistry. Herein, we report a strategy for in situ reactive atmosphere-induced reconstruc…
  europepmc 2026 置信度 0.80
• Anion Photoelectron Spectroscopy and Electronic Structure of UC2-/0.
  Anion photoelectron spectroscopy (aPES) of the uranium dicarbide molecular anion, UC2-, was performed in conjunction with ab initio electronic structure calculations to investigate the molecular and electronic structures of anionic and neutral UC2-/0. Our comb…
  europepmc 2026 置信度 0.80
• A Novel Cancer Driver Genes Identification Method Based on Self-Supervised Dual Masked Graph Autoencoder.
  Uncovering genes that drive cancer is fundamental to elucidating the mechanisms underlying cancer development and to advancing cancer research. Recent years have witnessed the emergence of cancer driver gene identification from multi-omics data as a key resear…
  europepmc 2026 置信度 0.80
• UDEC-MO: an uncertainty-guided deep embedded clustering framework for bulk and single-cell multi-omics data.
  Bulk and single-cell multi-omics technologies provide complementary molecular views for characterizing disease heterogeneity and cellular diversity. However, robust multi-omics clustering remains challenging due to high dimensionality, pervasive noise, modalit…
  europepmc 2026 置信度 0.80
• Achieving Superior Capacitive Energy Storage in Polymer Nanocomposites via a Hierarchical Interfacial Engineering of Gradient-Dielectric Ba(Zr,Ti)O&lt;sub&gt;3&lt;/sub&gt;@BaTiO&lt;sub&gt;3&lt;/sub&gt; Core-Shell Nanofibers.
  Harnessing dielectric polymers for next-generation pulsed-power capacitors mandates ultrahigh energy density and efficiency simultaneously, yet the antagonism between large polarization/dielectric constant and high breakdown strength remains a fundamental bott…
  europepmc 2026 置信度 0.80
• Molecular computing: A layer of logic.
  europepmc 2008 置信度 0.80
• QUANTUM INFORMATION METHODS FOR ENTANGLEMENT COMPUTATION: THE CASE OF THE HELIUM ATOM.
  The thesis aims to study the applicability of techniques of Quantum Information theory to complex systems, like molecules and biomolecules. Recently, concepts of Quantum Information theory have been applied to the study of phenomena involving molecules, for in…
  datacite S. Siccardi 2013 置信度 0.66
• SYNTHESIS AND CHARACTERIZATION OF NEW ORGANIC MOLECULES AND INORGANIC-ORGANIC HYBRID MATERIALS WITH INTERESTING LINEAR AND SECOND ORDER NON LINEAR OPTICAL PROPERTIES
  The different stages of technological evolution are characterized in terms of the dominant type of tools used in each of them. We passed through the `stone age', the `copper age' and the `iron age' and now we are probably in the `electron age'. After having do…
  datacite E. Tordin 2010 置信度 0.66
• Synaptic Continuity Protocol: A Physical and Information-Theoretic Framework for Consciousness Transfer Between Substrates
  The Synaptic Continuity Protocol (SCP) is a physical and information-theoretic framework for transferring consciousness between a biological and a synthetic neural substrate without interrupting awareness. The protocol combines (i) parallel fabrication of a sy…
  datacite Osiej, Bartosz 2026 置信度 0.66 consciousness transfermind uploadingneuromorphic computingmolecular manufacturingwhole-brain emulation
• The Quantum Constructor
  This paper presents the "Quantum Constructor" (QC), an advanced theoretical model that explores the convergence of fault-tolerant quantum computing and macro-scale physical synthesis. Rather than focusing on incremental advancements in additive manufacturing, …
  datacite Pajtim Bajrami 2026 置信度 0.66 quantum constructor⁠, ⁠quantum computation⁠, ⁠matter manipulation⁠, ⁠atomic reconfiguration⁠, ⁠post-scarcity physics⁠, ⁠fault-tolerant quantum computing⁠, ⁠theoretical physics⁠, ⁠global entanglement networks⁠, ⁠unified field interactions⁠, ⁠thermodynamic entropy control⁠, ⁠mass-energy equivalence⁠, ⁠Kardashev Type III⁠
• MBCT 1.0.0 — prebuilt Windows applications (full and core editions)
  Prebuilt Windows applications for MBCT (Multimodal Brain NetworkCharacterization Tool), version 1.0.0. This record contains the full and core editions, which bundle the completereference atlases and are therefore too large to attach to a GitHub release.The sma…
  datacite Klugah-Brown, Benjamin 2026 置信度 0.66
• Symmetry-based perturbation theory for electronic structure calculations
  We develop a multi-reference perturbation theory for electronic structure calculations based on symmetries of the Hamiltonian. The reference Hamiltonian in the symmetry-based perturbation theory (SBPT) is chosen such that it possesses more symmetries than the …
  datacite Nishimura, Hiromichi, Nguyen, Nam, Gujarati, Tanvi, Motta, Mario 2026 置信度 0.66 Quantum Physics (quant-ph)Chemical Physics (physics.chem-ph)FOS: Physical sciences
• kALDo 2.0: Scalable Thermal Transport from First Principles and Machine Learning Potentials
  We introduce kALDo2.0, an open-source Python package for computing vibrational, elastic, and thermal transport properties of solids from first principles and machine-learned interatomic potentials. Building on the anharmonic lattice dynamics (ALD) framework, k…
  datacite Barbalinardo, Giuseppe, Chen, Zekun, Folkner, Dylan, Li, Bohan 等 2026 置信度 0.66 Materials Science (cond-mat.mtrl-sci)FOS: Physical sciences
• QUANTUM DEEP LEARNING FRAMEWORK FOR ACCURATE MOLECULAR GROUND-STATE ENERGY PREDICTION IN COMPLEX CHEMICAL SYSTEMS
  Correct prediction of the molecular ground-state energy is a fundamental problem in quantum chemistry, materials science and drug screening and discovery which directly impacts the understanding of the stability and chemical behavior of molecules. For complex …
  datacite Giribabu, Sadineni, Tanguturi, Rama Chaithanya 2026 置信度 0.66 Quantum Deep Learning, Quantum Computing, Molecular Ground-State Energy, Variational Quantum Eigensolver, Quantum Chemistry, Deep Neural Networks.
• The Universal Invariant Proof — V3: A Formal Demonstration That Ψ_V3, Φ_critical, k=7, and Modulo-9 Are Natural Laws, Not Human Inventions
  WHAT THIS DEPOSIT CONTAINS This deposit presents two complete, formally verified software programs written in Ada/SPARK 2014. Together, they constitute a rigorous, mathematical demonstration that four universal invariants govern all complex systems — from the …
  datacite benhadid, OUTAIL 2026 置信度 0.66 universal invariants, Ψ_V3, Φ_critical, heptadic closure, modulo-9, formal methods, Ada SPARK, deterministic universe, natural laws, discovery vs invention, climate modeling, apoptosis, cosmology, Λ constant, fine structure constant, AI certification, DO-178C, quantitative finance, clinical medicine, aviation safety
• A New Perspektiv on Infinite Number Spaces through Prime Number Distance and Quantization
  Correction Notice: In version 1, I made an error in the description. Instead of "The space was divided into 11 discrete sections based on prime number gaps," it should correctly state: "The space was divided into 5 discrete sections based on prime number gaps"…
  datacite Boulfoul, Sebastian 2026 置信度 0.66 Prime Number GapsQuantization Number SpacesCyclic Number SystemsMathematical ConstantsPrime-Based Quantization
• Strong-Field-Driven Non-Linear Vibronic Coupling in an Asymmetric Donor-Acceptor Oligomer
  This dataset contains the supporting data associated with the study “Strong-Field-Driven Non-Linear Vibronic Coupling in an Asymmetric Donor–Acceptor Oligomer.” The dataset accompanies a Python-based analysis framework developed for the analysis and visualizat…
  datacite Theile, Jannik, Guerrini, Michele, Cocchi, Caterina 2026 置信度 0.66 DFTintramolecular charge transfer (ICT)laser-induced excitationelectron densitystrong-field excitation
• Runtime-Slayers/neural-magnetism-murburn: Neural Magnetism × Murburn Simulation Framework
  A professional, modular scientific computing and simulation framework investigating the biophysical interface of neural electromagnetic fields, mitochondrial Murburn bioenergetics, and the quantum radical pair mechanism (RPM). This repository models 19 coupled…
  datacite Muthu Raman Ramanathan 2026 置信度 0.66
• QumVQD: Qumode-Based Variational Quantum Deflation Framework
  Software accompanying the manuscript "Excited-State Quantum Chemistry on Qumode-Based Processors via Variational Quantum Deflation" (Jost & Dong, 2026). QumVQD is a framework for computing electronic and vibrational excited-state energies on bosonic / qumode q…
  datacite Jost, Marlon, Dong, Sijia 2026 置信度 0.66
• Improving fermionic variational quantum eigensolvers with Majorana swap networks
  Simulating computationally hard fermionic systems is a promising application of quantum computing. However, mapping nonlocal fermionic operators to qubits often produces deep circuits, rendering such simulations impractical on near-term hardware. We introduce …
  datacite Fisher, D. E., Fldzhyan, S. A., Minaev, D. V., Straupe, S. S. 等 2025 置信度 0.66 Quantum Physics (quant-ph)FOS: Physical sciences
• Understanding Molecular Simulation: From Algorithms to Applications
  Second and revised edition Understanding Molecular Simulation: From Algorithms to Applications explains the physics behind the recipes of molecular simulation for materials science. Computer simulators are continuously confronted with questions concerning …
  openalex Mark A. Ratner 1997-07-01 置信度 0.72 Computer scienceAlgorithm
• STRING v10: protein–protein interaction networks, integrated over the tree of life
  The many functional partnerships and interactions that occur between proteins are at the core of cellular processing and their systematic characterization helps to provide context in molecular systems biology. However, known and predicted interactions are scat…
  openalex Damian Szklarczyk, Andrea Franceschini, Stefan Wyder, Kristoffer Forslund 等 2014-10-28 置信度 0.72 BiologyString (physics)Tree (set theory)Tree of life (biology)Computational biology
• BrainRC: Brain-Inspired Reservoir Computing for Cardiac Arrhythmia Classification
  Source code, processed data, and manuscript companion files for the paper: Anatomically-Constrained Regional Connectivity as a Computational Resource in Reservoir Computing: Evidence from Multi-Class Cardiac Arrhythmia Classification Luiz Ricardo Mantovani da …
  datacite Mantovani da Silva, Luiz Ricardo 2026 置信度 0.66 reservoir computingecho state networkbrain-inspired computingneuromorphic computingECG arrhythmia classification
• V3 Apoptosis Architecture: A Formal Methods Approach to Computational Systems Biology and Translational Oncology
  Abstract: This deposit presents the V3 Apoptosis Architecture, a complete computational framework that applies aerospace-grade formal methods (Ada/SPARK 2014) to the modeling of programmed cell death (apoptosis) and translational oncology. The deposit includes…
  datacite benhadid, OUTAIL 2026 置信度 0.66 apoptosis, formal methods, Ada SPARK, HPC, systems biology, oncology, saturating arithmetic, heptadic closure, precision medicine, drug discovery, translational oncology, cancer research, computational biology, formal verification, DO-178C, GNATprove, Bcl-2, Bax, caspases, apoptosome, Apaf-1, Cytochrome c, XIAP, MOMP, commitment point, reverse engineering, virtual clinic, high-performance computing, parallelization, deterministic simulation, clinical trials, personalized medicine, saturating addition, saturating subtraction, saturating multiplication, saturating division, range clamping, digital root, modulo-9 invariant, SPARK contracts, preconditions, postconditions, static analysis, absence of exceptions, runtime verification, dataflow analysis, race-condition freedom, pure functions, mitochondrial apoptosis, intrinsic pathway, programmed cell death, Bcl-2 family, pro-apoptotic proteins, anti-apoptotic proteins, caspase cascade, caspase-3, caspase-9, procaspase activation, cytochrome c release, apoptosome assembly, macromolecular complex, structural biology, electron microscopy, kinetic constants, k_on, k_off, K_d, drug resistance, tumor proliferation, oncogenesis, precision oncology, personalized medicine, virtual clinical trials, biopsy proteomics, drug screening, combination therapy, synergistic effects, therapeutic inhibition, targeted therapy, chemotherapy optimization, treatment resistance, patient stratification, clinical translation, Ada programming language, SPARK 2014, GNAT compiler, formal software verification, software integrity, deterministic execution, reproducible research, parallel computing, multi-core scaling, CPU saturation, zero-overhead execution, no hidden side effects, pure functions, immutable state, contract-based design, safe arithmetic, integer bounds
• A comparative study of <i>Zingiber officinale</i> Roscoe pulp and peel: phytochemical composition and evaluation of antitumour activity
  Colon cancer is one of the major causes of cancer mortality worldwide. Hydroalcoholic extract of ginger peel extract was more potent against colon cancer cells than ginger pulp hydroalcoholic extract using MTT assay, while ginger pulp hydroalcoholic extract sh…
  datacite Mariangela Marrelli, Francesco Menichini, Filomena Conforti 2015 置信度 0.66 Plant BiologyHematologyScience PolicyCancerInformation and Computing Sciences
• A Novel Approach On Medication Dispency
  Robotics for medical applications started fifteen years ago while for biological applications it is rather new (about five years old). Robotic surgery can accomplish what doctors cannot because of precision and repeatability of robotic systems. Besides, robots…
  datacite V, Vijitha., V, Raadhugaa. S., P, Naveen. S 2020 置信度 0.66 Pharmaceutical fieldRoboticsAutomated dispensing mechanismsCard readerCloud computing.
• An accordion superlattice for controlling atom separation in optical potentials
  We propose a method for separating trapped atoms in optical lattices by large distances. The key idea is the cyclic transfer of atoms between two lattices of variable spacing, known as accordion lattices, each covering at least a factor of two in lattice spaci…
  datacite Wili, Simon, Esslinger, Tilman, Viebahn, Konrad 2023 置信度 0.66 quantum technologiesneutral atom quantum information processingoptical latticeaccordion latticeoptical tweezer array
• MetaWare. Engineering and Construction via Metamaterial Coupling Mechanics. Transitioning from Silicon to an Invariant Information Core and Processing Based on Fractal Etching of the Koch Curve on a Vacuum Manifold, Replacing Wiring with Metamaterial Gravitational Shielding, and Replacing Thermal Conduction with Topological Conduction. (2).
  بر اساس چارچوب دقیقِ ارائه شده در مدلِ متا-افزار (Meta-Apparatus) و با استناد به داده‌های فنیِ موجود، جدول نهاییِ قطعاتِ شیلدِ گرانشی با تکمیلِ جزئیاتِ شیمیایی، لیتوگرافی و ریاضیاتی به‌صورت زیر تدوین می‌گردد: جدول شماره ۱ از ۵: قطعات متاماده متالورژیکی و کدهای…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• VU Bioinformatics/NGS Suite: MicroRNA–Target Gene Mapping Bar Plot
  VU Bioinformatics/NGS Suite: MicroRNA–Target Gene Mapping Bar Plot What is this work about? This work is part of a research project investigating the role of microRNAs (miRNAs) in regulating gene expression relevant to disease pathways. MicroRNAs are small non…
  datacite Vasishta, Sampara, Adiga, Usha, Adiga, Sachidananda 2026 置信度 0.66 miRNAGene LibraryMutationBioinformaticsMicroRNAs
• Quantum Consciousness Roadmap Diagram — From Physics to Immortality
  Description: This diagram illustrates the categorical framework and convergence timeline for the proposed Quantum Consciousness Roadmap. It integrates five conceptual layers — Foundational Physics, Neuroscience Integration, Quantum Simulation, Digital Immortal…
  datacite Sewell, Melvin 2026 置信度 0.66
• Circulating B-Cell Receptor (BCR) Repertoire Diversity as a Biomarker of Immunotherapy Response
  The immunotherapy of cancer has revolutionized the treatment of oncologic cancer, but the patient response has been very heterogeneous and this has greatly raised the need to develop strong, minimally invasive, biomarkers that predict and monitor the reaction …
  datacite Kanthakhoo, Nongnapat 2026 置信度 0.66 B-cell receptor; repertoire; immunotherapy; biomarkers; immune repertoire sequencing; checkpoint inhibitors; BCR diversity
• E = c ∞ :THE UNIVERSAL HONEYCOMB AETHER
  The Formula: E = c times INFINITY [Plain Text Representation] E = c * INFINITY (E equals c times INFINITY) SUPPLEMENTAL EXEGESIS THE GEOMETRIC SOURCE CODE 1 THE HONEYCOMB LATTICE AS THE OPERATOR OF INFINITY The term INFINITY in this equation is the physical ma…
  datacite Fairy Monk (Independent Researcher) A=A' 2026 置信度 0.66
• Hardware-Flesh-Software-Flesh
  Mona Hedayati's experimental visual essay combines strands of technical critique, poetic reflection, and embodied experience to challenge how biometric data is captured, integrated, and interpreted. Drawing on her ongoing artistic research with biosensor weara…
  datacite Hedayati, Mona 2025 置信度 0.66
• From Data Aggregation to Mechanistic Simulation: A Product Ladder Framework for Personal Biological Digital Twins
  Proposes a three-tier product ladder for personal biological digital twins — aggregation, AI interpretation, and mechanistic simulation — mapped to Carlile's knowledge boundary framework. Addresses how to commercialize biological digital twins by delivering in…
  datacite Waern, Nicolas 2026 置信度 0.66 biological digital twinproduct ladderpersonal health dataedge computingmechanistic simulation
• **"Organoid Intelligence: Bridging Biology and Artificial Intelligence — A Comprehensive Study of Brain Organoid Biocomputing, Ethical Challenges, and Governance Frameworks"** ---
  ## Alternative Titles 1. **"From Mini-Brains to Biocomputers: The Rise of Organoid Intelligence in Laboratory-Developed Neural Networks"** 2. **"Minds in a Dish: Organoid Intelligence and the Future of Biological Computing"** 3. **"The Convergence of Stem Cell…
  datacite geruganti, sudhakar 2026 置信度 0.66
• A Measured Quantum–Classical Resource Asymmetry on IBM Kingston: Empirical Grounding for the Computational Argument in the Quantum-Simulator Hypothesis
  Amit Brahmbhatt Quantum-Clarity LLC Email: amit@quantum-clarity.com Date: April 2026 Platform: IBM Kingston (156-qubit Heron r3 heavy-hex superconducting processor) Related deposits: PBR-inspired entanglement validation — Zenodo DOI 10.5281/zenodo.17883261 Y⊗Z…
  datacite Brahmbhatt, Amit 2026 置信度 0.66 quantum computing; IBM Kingston; Heron r3; resource asymmetry; quantum advantage; quantum simulation; classical simulation; Hilbert space scaling; state-vector memory; random quantum circuits; computational complexity; quantum-simulator hypothesis; simulation hypothesis; quantum foundations; Feynman quantum simulator; Lloyd programming the universe; native-edge circuits; heavy-hex topology; NISQ benchmarking; superconducting qubits; exponential scaling; scaling study
• The Computational Architecture of Relational Constraints
  The Computational Architecture of Relational Constraints Dimensional Emergence, Resolution Collapse, and Coordinate Decomposition Driven by Dean A. Kulik August, 2028 The pursuit of fundamental invariants across mathematics, computational theory, and theoretic…
  datacite kulik, dean 2026 置信度 0.66
• Solving the Complex Metabolic Networks of Living Organisms with Real Quantum Computers... A Practical Breakthrough in Systems B
  • Published in the international journal Patterns, successfully implementing the dynamics of biological Boolean networks (BNs) on a real quantum processing unit (QPU). • Demonstrated the efficiency of utilizing quantum superposition states to compute gene knoc…
  datacite inquantio 2026 置信度 0.66 quantum biology
• WRI OS™ 2: Coherence Computing and Ambient Environmental Interface Infrastructure
  This publication expands Derek Antoine Lee's Bonded Science™ technology ecosystem by introducing a distributed ambient interface and environmental computation architecture that merges my previous inventions WRI OS™, Coherence Computing™, biological telemetry s…
  datacite Lee, Derek Antoine 2026 置信度 0.66
• Rehab-RL MBEC Deposit: Data and Code for "A Reinforcement Learning Framework for Personalized Rehabilitation Therapy Recommendation Using Synthetic Patient Cohorts
  This deposit contains the data and code accompanying the manuscript "A Reinforcement Learning Framework for Personalized Rehabilitation Therapy Recommendation Using Synthetic Patient Cohorts" by Arar al Tawil (Department of Computer Science, Faculty of Informa…
  datacite AL Tawil, Arar 2026 置信度 0.66
• CosmosBeating • Formic Geometry and Topology — Paper X: General Introduction and Master Index
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Master index; glossary; cross-series boundary; reading path; CB•FGnT; Holo- graphic Information Ontological Framework; Information Compatibility Principle II; evidentiary grading; CosmosBeating.
• CosmosBeating • Formic Geometry and Topology — Paper IX Reboot Protocols and Closure
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Nuptial flight; claustral colony founding; colony budding; colony fission; found- ing mortality; intergenerational continuity; dispersal strategy; Atta sexdens; CosmosBeating; falsifiability.
• CosmosBeating • Formic Geometry and Topology — Paper VIII: Architecture and Microclimate
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Mound orientation; active thermoregulation; solar collection; ventilation turrets; carbon dioxide concentration; brood relocation; Formica polyctena; Atta vollenweideri; Cosmos- Beating; falsifiability.
• CosmosBeating • Formic Geometry and Topology — Paper VII: Boundaries, Conflict, and Parasitism
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Territorial conflict; recruitment dynamics; dulosis; slave-making ants; Polyergus; chemical mimicry; host recognition systems; Tetramorium; social parasitism; CosmosBeating; falsifiability.
• CosmosBeating • Formic Geometry and Topology — Paper VI:Task Economics
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Caste polymorphism; age polyethism; response threshold model; task allocation; division of labour; Pogonomyrmex barbatus; interaction rate; command-free coordination; Cos- mosBeating; falsifiability.
• CosmosBeating • Formic Geometry and Topology — Paper V S:pacetime and Probability
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Pheromone volatility; quorum sensing; Temnothorax albipennis; environment as memory; spacetime discretisation; probabilistic path superposition; distributed decision-making; Linepithema humile; CosmosBeating; falsifiability.
• CosmosBeating • Formic Geometry and Topology — Paper IV: Interface and Symbiosis
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Ant–plantmutualism; Pseudomyrmex; Acacia; extrafloralnectaries; Beltianbodies; patrol density; dynamic pricing; biological markets; partner choice; CosmosBeating; falsifiability.
• Matrices, Calculus, and Exponential Models: Mathematical Applications in Science and Biotechnology
  This academic report was prepared as part of my degree programme. It explores the principles of matrix algebra, differential and integral calculus, and exponential growth and decay models, with emphasis on their applications in biology, medicine, chemistry, ge…
  datacite Sri Wijebandara, Rishmi Ayodhya 2025 置信度 0.66 Applied Mathematics Matrix Algebra Matrices Differential Calculus Integral Calculus Exponential Growth Exponential Decay Mathematical Modelling Scientific Computing Biotechnology Biomedical Science
• CosmosBeating • Formic Geometry and Topology — Paper III: Thermodynamics and Clearance
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Necrophoresis; oleic acid; wound-entropy; topological compartmentalisation; waste management; nest sanitation; distributed clearance; Atta; harvester ants; CosmosBeating; falsi- fiability.
• CosmosBeating • Formic Geometry and Topology — Paper II: Geometry and Topology
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Tunnel geometry; chamber architecture; no-blind-spot principle; Murray's Law; Atta; leaf-cutter ants; dynamic excavation; sedimented computation; CosmosBeating; falsifiabil- ity.
• Sculpting Intelligence from the Fabric of Reality
  The universe, viewed at its most fundamental level, is not merely a collection of discrete particles and localized forces but an intricately interconnected, dynamic fabric woven from latent information and emergent potentiality. This foundational substrate can…
  datacite Quni-Gudzinas, Rowan Brad 2025 置信度 0.66 epistemologyphilosophy of scienceconsilience
• CosmosBeating • Formic Geometry and Topology — Paper I: Collective Information Mechanisms
  CosmoBeating - Formic Geometry and Topology (CB-FGaT) A Complex-Systems Reading of Ant Colonies This is a short, non-technical companion to the 11-paper CB-FGaT series. It is written for readers with a background in entomology, behavioural ecology, or complex …
  datacite Tam, Wai-Hung (Pan) 2026 置信度 0.66 Stigmergy; pheromone trail; response threshold model; collective behaviour; emer- gence; distributed cognition; Pogonomyrmex barbatus; task allocation; CosmosBeating; Holo- graphic Information Ontological Framework; falsifiability.
• Emergent Computation: An Analysis of the Physical Computation Paradigm Shift from Abstract Logic to Embodied Dynamics
  The classical Turing-von Neumann architecture, which has defined the digital epoch, is confronting insurmountable energetic and structural limits, most notably the von Neumann bottleneck. This necessitates a paradigm shift toward physical computation, a framew…
  datacite Quni-Gudzinas, Rowan Brad 2025 置信度 0.66 philosophy of physicsfoundations of quantum mechanicsepistemology
• Computational Universe: A Unified Theory of Multi-Scale Computation
  This work establishes computation as an ontological primitive from which physical reality emerges. Spacetime, matter, and energy are derived from a self-computing causal network of distinctions ($A \neq B$) realized through spontaneous symmetry breaking. The b…
  datacite Quni-Gudzinas, Rowan Brad 2025 置信度 0.66 epistemologyphilosophy of scienceconsilience
• Differentiable Design for Morphogenesis I: Simulation and Simulacra
  Cells build tissues through local exchanges of force and information, yet the rules governing these interactions are difficult to infer from sparse observations. Here, we introduce waxMorph , a differentiable cell-based framework for generating and reconstruct…
  europepmc 2026 置信度 0.80
• Intelligent Decision Support Systems for Aquaponics Monitoring and Growth Management
  Abstract Aquaponics, the integration of aquaculture and hydroponics, presents a sustainable solution to modern agricultural challenges by enabling efficient resource utilization and environmentally friendly food production. This study proposes a novel decision…
  europepmc 2026 置信度 0.80
• Multi-Omics Modeling Reveals Peripheral Signatures of Non-Suicidal Self-Injury in Adolescents
  Non-suicidal self-injury (NSSI) is common among adolescents with emotional disorders, yet biological indicators of current NSSI status remain limited. We developed a genome-aware multi-omics modeling framework in 107 adolescents with emotional disorders, inclu…
  preprints 2026 置信度 0.74
• Scalable and robust phylogenetic tree reconstruction from copy-number data with Sparse Rooted Neighbor Joining
  Background Phylogenetic tree reconstruction from single cell data based on copy-number alterations (CNAs) is an important problem in cancer genomics. Methods have been developed to address this problem by computing pairwise distances between copy-number profil…
  preprints 2026 置信度 0.74
• A Synchronization-Driven Learning Rule for Pattern Separation in Self-Organizing Probabilistic Spiking Neural Networks
  Abstract Neuroscience-inspired neural networks provide a promising framework for bridging biological principles and adaptive artificial intelligence systems. Here, we propose a novel synchronization-based synaptic learning rule for self-organizing probabilisti…
  preprints 2026 置信度 0.74
• Topological Entropy Correlates with the Predictive Power of Multiplexed Ensemble Reservoir Computing
  Modeling nonlinear, multiscale, and transiently chaotic biological processes remains a major challenge in computational biology. Traditional deep learning models, while powerful, require large datasets and lack mechanistic interpretability, limiting their effe…
  europepmc 2026 置信度 0.80
• Learning complex temporal dependencies via local synaptic plasticity
  The ability to extract and exploit temporal structure across diverse tasks is central to human cognition. Neuroscientists have typically relied on recurrent neural networks (RNNs) trained with backpropagation through time (BPTT) when modelling neural and behav…
  preprints 2026 置信度 0.74
• Directional information flow as a tool for analyzing protein allostery
  ABSTRACT The ability to tune protein function through the binding of modulatory ligands enables the development of therapeutics that steer a biological system away from dysfunctional states underlying disease. Understanding the dynamic mechanisms by which allo…
  preprints 2026 置信度 0.74
• Topological Probing of Latent Space Geometry in Protein Foundation Models under Distribution Shift
  Abstract Foundation models trained on biological sequences encode rich representations of evolutionary and functional information in their hidden states. A fundamental question for deploying these models in scientific applications is whether their internal rep…
  preprints 2026 置信度 0.74
• Research on Intelligent Recognition Method of Tobacco Leaf Maturity Based on Deep Learning
  Abstract Automated tobacco maturity assessment is vital for precision agriculture but remains challenging due to complex field conditions and irregular canopy overlapping in unstructured environments. To overcome these limitations, this study proposes an intel…
  preprints 2026 置信度 0.74
• Autopoietic Computing and the Emergence ofSentience in Brain Organoids
  Contemporarybiocomputingoftenapproachesbrainorganoidsasallopoieticsub-strates for logical processing, neglecting the existential imperatives that drive biolog-ical cognition. This paper proposes a fundamental paradigm shift from AllopoieticComputing toward Aut…
  preprints 2026 置信度 0.74
• PlumageParts: A fine-grained avian plumage segmentation dataset and benchmark for ecological image analysis
  Fine-grained localisation of plumage regions is a prerequisite for computational analyses of avian colouration, patterning and visual traits in ecological and evolutionary research. Progress is limited by the scarcity of image resources with annotations aligne…
  preprints 2026 置信度 0.74
• MorphoCloud: Democratizing Access to High-Performance Computing for Morphological Data Analysis
  Background The digitization of biological specimens has revolutionized morphology, generating massive 3D datasets such as microCT scans. While open-source platforms like 3D Slicer and SlicerMorph have democratized access to advanced visualization and analysis …
  preprints 2026 置信度 0.74
• A workflow for impact indicators of alien species for policy: A demonstration with Acacia species
  The negative impact of alien species is recognised as a major threat to biodiversity. However, there is a lack of evidence-based impact indicators that adhere to the Findable, Accessible, Interoperable, and Reusable (FAIR) Data Principles and employ standardis…
  preprints 2026 置信度 0.74
• Clarifying and Standardizing the Lévy Flight in Scientific Computing
  The Lévy flight is a fundamental stochastic model widely utilized across various domains, including engineering optimization and biological foraging. However, the current literature reveals notable inconsistencies in its definition, parameter interpretation, a…
  preprints 2026 置信度 0.74
• A novel Boltzmann equation solver for calculation of dose and uence spectra distributions for proton beam therapy
  Abstract Background: The claim that Monte Carlo is the most accurate method is a case of misattributed credit. This claim is based on experience with advanced systems MC- NPX, Geant4 and EGS. These systems achieve remarkable performance because they use most a…
  preprints 2026 置信度 0.74
• DelRec: learning delays in recurrent spiking neural networks
  Abstract Biological neurons transmit information with stereotyped electrical impulses called ``spikes'', sensitive to coincident timings. Spiking Neural Networks (SNNs), introduced in the nineties, have gained popularity in AI for their energy efficiency and c…
  preprints 2026 置信度 0.74
• Epistatic SNP network analysis (ESNA): A scalable framework for genome-wide detection of higher-order genetic interactions
  Although genome-wide association studies (GWASs) have been widely applied to investigate the genetic basis of common traits and diseases in human populations, the associated loci do not fully account for the estimated heritability. The missing heritability may…
  preprints 2026 置信度 0.74
• Edge-GNN: A Constraint-Aware Graph Neural Network Framework for Resource-Efficient Biological Interaction Modeling
  Abstract Graph neural networks (GNNs) have become an effective framework for modeling biological interaction networks such as protein–protein interaction graphs and gene regulatory systems. However, many existing GNN approaches are designed primarily for high-…
  preprints 2026 置信度 0.74
• Algorithm for Describing Neuronal Electric Operation
  The development of neuroanatomy and neurophysiology has revealed many new details about neurons’ electrical operation over the past few decades, requiring modifications to their theoretical models. The development of computing technology enables us to consider…
  europepmc 2025 置信度 0.80
• Neuro-Hormonal Networks: A Bio-Inspired Architecture forEnhanced Deep Learning Performance
  Abstract In this work, neuro-hormonal networks (NHNs) are presented which are a novel bioinspireddeep learning architecture that integrates dynamic neuro-modulation mechanismsto achieve superior performance in deep learning tasks. Our approach addresses fundam…
  preprints 2026 置信度 0.74
• Molecular Dynamics Simulations: Principles, Algorithms, and Emerging Applications
  Molecular dynamics (MD) simulation is a fundamental technique for resolving biomolecular structures and functions at atomic resolution. Accelerated by GPU computing and machine learning-integrated force fields (FF), modern MD simulation facilitates the study o…
  preprints 2026 置信度 0.74
• Credit Assignment Under Constraint: Why Learning Must Be Local in Neural Systems
  Credit assignment in neural systems is commonly framed as the problem of computing or approximating gradients of a global objective. Under realistic constraints of partial observability, noise, delay, and high dimensionality, global credit assignment is comput…
  preprints 2026 置信度 0.74
• Multi-Stage Graph Attention Networks for Interpretable Alzheimer’s Disease Classification from Genome-Wide Association Data
  Background Genome-wide association studies have identified numerous variants associated with neuropsychiatric disorders. Although some significant loci can carry substantial risk, as in Alzheimer’s Disease, the remaining genetic variance is distributed across …
  preprints 2026 置信度 0.74
• An Efficient Computing Theory of Prefrontal Structured Working Memory Representations
  A bstract The efficient coding hypothesis presents a compelling success story for theoretical and systems neu-roscience. It marshals a unifying idea, that neural codes can be understood as efficient encodings of natural stimuli, to explain phenomena from acros…
  preprints 2026 置信度 0.74
• Evolutionarily Optimized Network Topology as a Structural Prior for Data-Efficient Sparse Neural Classification
  Biological neural systems have been refined over millions of years of evolutionary optimization to maximize information processing under metabolic and developmental constraints, yielding network topologies with characteristic structural signatures: sparse conn…
  preprints 2026 置信度 0.74
• Predictive tactile coding in a memristive neuromorphic tactile system
  Abstract Flexible tactile electronics have progressed rapidly in wearable electronics, electronic skin, tactile sensing materials and neuromorphic sensory devices, yet most artificial touch systems still interpret contact only after the signal has already been…
  preprints 2026 置信度 0.74
• A Closer-to-Brain Heterosynaptic Learning Rule for Spatiotemporal Spike Pattern Detection with Low-Resolution Synapse
  The brain is believed to process information efficiently in a different manner from deep learning-based artificial intelligence (AI). Brain-like next-generation AI is gaining attention owing to its potential to perform human-like, highly adaptive, robust, and …
  preprints 2026 置信度 0.74
• Edge-Based Execution of Graph Neural Networks for Protein Interaction Network Analysis in Clinical Oncology
  Abstract Graph Neural Networks (GNNs) are increasingly used to model protein–protein interaction networks in cancer biology but are commonly deployed using central ized, cloud-based GPU infrastructure. This study examines the computational feasibility and nume…
  preprints 2026 置信度 0.74