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• TimeTraits: extracting functional traits from biological time-series in R
  Summary TimeTraits provides a series of functions to enable the extraction of parameters from time series data using Functional Data Analysis methods. We demonstrate its utility in dissecting the changes in curve shape of a circadian clock bioluminescence mark…
  europepmc 2026 置信度 0.80
• SE-SNN: Squeeze-and-Excitation Enhanced Spiking Neural Networks with Learnable Neuron Dynamics for Event-Based Vision
  Spiking Neural Networks (SNNs) have emerged as a promising paradigm for energy-efficient neuromorphic computing, particularly when processing asynchronous event streams from dynamic vision sensors (DVS). However, SNNs often suffer from limited representational…
  preprints 2026 置信度 0.74
• Energy-precision trade-off in mitotic oscillators revealed by ATP modulation in artificial cells
  The temporal precision of biochemical oscillators is fundamentally constrained by the energy dissipated to suppress molecular fluctuations, a widely predicted trade-off governing information processing across biology and physics, from molecular motors to kinet…
  preprints 2026 置信度 0.74
• quantmsdiann: a scalable SDRF-driven DIA-NN workflow for reanalysis of single-cell, spatial, and bulk proteomics datasets
  Abstract Public proteomics archives now hold thousands of data-independent acquisition (DIA) datasets, but reusing them is difficult: each was processed with a different software configuration, and most lack standardized metadata. Here, we present quantmsdiann…
  preprints 2026 置信度 0.74
• Cost-function Optimized Maximal Overlap Drift Estimation for Single Molecule Localization Microscopy
  Single-molecule localization microscopy (SMLM) methods enable fluorescence imaging of biological specimens with nanometer-scale resolution. Although fluorophore localization precision is theoretically limited only by photon statistics, in practice the resoluti…
  preprints 2026 置信度 0.74
• Inductor-Stabilized Charge-Controlled Memristor Neuromorphic Circuit Design With Complex Firing Dynamics
  Abstract Neuromorphic circuits based on memristive devices have attracted increasing attention for their potential to emulate biological neuronal dynamics and enable energy-efficient brain-inspired computing. In this paper, an inductor-stabilized charge-contro…
  preprints 2026 置信度 0.74
• Revealing imatinib-kinase specificity via analyzing changes in protein dynamics and computing molecular binding affinity
  Drug promiscuity is a double-edged sword where a small molecule acts on multiple biological targets to induce toxicological or therapeutic benefits. It is possible to exploit promiscuity to expand treatment options without the prohibitive costs of designing a …
  preprints 2026 置信度 0.74
• The Stochastic System Identification Toolkit (SSIT) to model, fit, predict, and design experiments
  Biological data is prone to both intrinsic and extrinsic noise and variability between experimental replicas. That same stochasticity and heterogeneity can carry information about underlying biochemical mechanisms but, if not incorporated in modeling and proba…
  preprints 2026 置信度 0.74
• Lunar Quantum Data Center
  Artificial intelligence, cloud infrastructure and quantum computing are consuming Earth's energy and water resources faster than any other human technology. Data centers already account for nearly two percent of global electricity use and trillions of liters o…
  europepmc 2025 置信度 0.80
• PhytoScan3D: an open-source Python pipeline for batch extraction of phenotypic traits from 3D point cloud files generated by multispectral plant phenotyping sensors
  High-throughput 3D multispectral plant phenotyping platforms generate large volumes of point cloud files, but trait extraction is typically performed by sensor-bundled software whose internal algorithms are not publicly documented, which limits reproducibility…
  preprints 2026 置信度 0.74
• CellAwareGNN: Single-Cell Enhanced Knowledge Graph Foundation Model for Drug Indication Prediction
  Graph foundation models have emerged as powerful tools for drug repurposing by enabling the prediction of novel drug–disease indications from large biomedical knowledge graphs. A representative example is TxGNN, which was previously developed and trained on Pr…
  preprints 2026 置信度 0.74
• Computing the lateral diffusion coefficient of lipids on lipid membranes
  Abstract In biological membranes, lateral diffusion refers to the movement of constituent molecules, such as lipids and proteins, within each leaflet of the bilayer. Understanding this process is crucial for elucidating membrane dynamics, molecular interaction…
  europepmc 2025 置信度 0.80
• A high-performance end-to-end 3D CLEM processing workflow for facilities
  Correlative Light and Electron Microscopy (CLEM) integrates the molecular specificity of light microscopy (LM) with the ultrastructural detail of electron microscopy (EM), enabling comprehensive spatial analysis of biological samples. Despite growing demand, p…
  preprints 2026 置信度 0.74
• Scalable and sustainable N-Si-Ge-Te Ovonic threshold switching devices for energy-efficient artificial neuron applications
  Abstract Neuromorphic computing, inspired by biological nervous systems, yields high energy efficiency and data throughput by integrating computation and storage within memory crossbar arrays. A key requirement for neuromorphic hardware is an artificial neuron…
  europepmc 2025 置信度 0.80
• GPU-accelerated modeling of biological regulatory networks
  Abstract The complex regulatory dynamics of biological networks can be succinctly captured using discrete logic models. Previous work has shown that global optimization schemes are well suited for finding state transition logic and kinetic model parameters, in…
  preprints 2026 置信度 0.74
• Measuring Coherence Exhaustion: Operational Detection of Scaling Limits in Complex Systems
  Complex systems degrade at scale when constraint burden exceeds available control capacity. Prior work introduced the Constraint-based Epistemology of Scaling (CES), defining coherence budget exhaustion as the transition where constraint geometry dominates sys…
  preprints 2026 置信度 0.74
• Interference-Feedback Computing for Bi-Directional Wave Transcription: A Unified Framework for Wave Encoding, Recursive Memory, and Signal-Preserved Bit-stream Extraction from EEG Data Using Quantum Hardware
  Interference-Feedback Computing (IFC) represents a hardware-native, wave-based computational archi- tecture enabling nonlinear processing, internal memory, and temporal inference directly within physical interference media. Originally developed for photonic an…
  europepmc 2025 置信度 0.80
• Information Abstraction for Data Transmission Networks based on Large Language Models
  Abstract Biological systems, particularly the human brain, achieve remarkable energy efficiency by abstracting information across multiple hierarchical levels. In contrast, modern artificial intelligence and communication systems often consume significant ener…
  preprints 2026 置信度 0.74
• Investigating the fundamental characteristics of retinal age models
  Abstract Retinal age is a biological ageing marker estimated from retinal images. Its deviation from chronological age, termed the retinal age gap (RAG), has been associated with adverse health outcomes. However, fundamental characteristics of retinal age mode…
  preprints 2026 置信度 0.74
• Quantum-Dot Neuromorphic Edge AI for Ultra-Secure IoT and Brain-Inspired Computing
  In order to achieve ultra-secure, adaptive, and low-power intelligence for distributed IoT environments, this paper presents a next-generation neuromorphic edge architecture that combines quantum-dot nanomaterials with spiking neural computation. Because of th…
  europepmc 2025 置信度 0.80
• Constraint Geometry and Coherence Budgets: A Framework for Diagnosing Scaling Limits in Complex Systems
  Complex systems routinely exhibit degradation as scale increases. In computing platforms, networked infrastructures, biological systems, and organizations, performance collapse or loss of controllability often emerges despite improvements in local components. …
  preprints 2026 置信度 0.74
• Design and Validation of an IoT-Based Blood Pressure Monitoring System for Rabbits
  Telemedicine, driven by the Internet of Things (IoT) and next-generation mobile networks, is essential for managing cardiovascular diseases, where hypertension remains the primary risk factor. In preclinical research, rabbits are superior biological models com…
  preprints 2026 置信度 0.74
• MAMGL: A memory-augmented meta-graph learning framework for adolescent major depression disorder diagnosis
  Background Adolescent major depressive disorder (AMDD) is a prevalent and heterogeneous psychiatric condition that emerges during a critical period of brain development. Neuroimaging-based biomarkers derived from resting-state functional magnetic resonance ima…
  preprints 2026 置信度 0.74
• A ratio-based framework using Quartet reference materials for integrating long- and short-read RNA-seq
  Long-read RNA sequencing (lrRNA-seq) enables full-length transcript profiling but is confounded by technical batch effects that compromise quantification and prevent data integration across platforms, protocols, and laboratories. The lack of a transcriptome-wi…
  europepmc 2025 置信度 0.80
• Harnessing Dynamics of Van Der Pol Oscillators for Phase Computing with Oscillatory Neural Networks
  Abstract An oscillatory neural network (ONN) is a novel physics-based computing architecture that leverages the collective dynamics of coupled oscillators with sinusoidal Kuramoto oscillators being typically chosen. However, van der Pol (vdP) oscillators intro…
  preprints 2026 置信度 0.74
• Multiphasic Transport in the Human Cranial Dura: How Meningeal Lymphatic Vessels Drive Waste Clearance from Cerebrospinal Fluid
  Abstract Background: The discovery of meningeal lymphatic vessels (mLVs) has reshaped our understanding of brain waste clearance, positioning them as a very important clearance route. However, quantifying the precise hydrodynamics and solute transport mechanis…
  preprints 2026 置信度 0.74
• Fusion of lipid membranes: an alternative pathway
  Membrane fusion is ubiquitous in myriad biological processes, including presynaptic neurotransmitter release, myoblast fusion, virus entry, and fertilization 1–3 . It is often considered in the presence of fusogenic proteins, which mediate the fusion by pullin…
  preprints 2026 置信度 0.74
• Critical intelligence: computing defensive behaviour
  Characterising the mechanisms underlying naturalistic defensive behavior remains a significant challenge. While substantial progress has been made in unravelling the neural basis of tightly constrained behaviors, a critical gap persists in our comprehension of…
  europepmc 2025 置信度 0.80
• KaroSpace: a rapid-access framework for interactive exploration of multi-sample spatial omics data
  Spatial omics technologies enable high-resolution mapping of molecular and cellular organization within tissues, yet interactive exploration of these data remains challenging due to computational bottlenecks, and reliance on proprietary software infrastructure…
  preprints 2026 置信度 0.74
• Transcriptional signatures underlying divergent lifestyles of endophytic and pathogenic fungi in early colonisation of wheat roots
  Wheat take-all is a root disease which devastates crop yields, caused by the ascomycete fungus Gaeumannomyces tritici . The closely related root endophyte, G. hyphopodioides , has been found to induce local host defence responses which confer protection agains…
  europepmc 2026 置信度 0.80
• Uncertainty-Aware Gene Rankings Reveal Key Players in Coexpression Networks
  Motivation Key genes of a biological system are often prioritized by computing network science measures on a coexpression network inferred from transcriptomic data. But human population heterogeneity and modest sample sizes introduce uncertainty in the inferre…
  europepmc 2025 置信度 0.80
• Longitudinal insights into dynamic patterns and cumulative burdens of biological age acceleration in relation to type II diabetes mellitus, all-cause mortality and glycemic traits
  Background: Accelerated biological aging (BioAgeAccel) has been implicated in type II diabetes (T2D) mellitus development; however, its dynamic changes and their links to T2D incidence, mortality and glycemic traits remain unclear. Methods: Leveraging repeated…
  europepmc 2026 置信度 0.80
• IoT and Cloud Computing in Biological Water Monitoring: A Systematic Review of Challenges, Architectures, and Emerging Trends
  Abstract The integration of Internet of Things (IoT) and cloud computing technologies has revolutionized biological water quality monitoring by enabling high-resolution, real-time sensing and data analytics. Despite the potential, various challenges persist in…
  preprints Ronewa Nethanani, Yoren Ndou, Wilson Nchabeleng, Sifundo Ndlovu 2025 置信度 0.74
• Online supervised learning of temporal patterns in biological neural networks under feedback control
  ABSTRACT In vitro biological neural networks (BNNs) provide a well-defined model system to constructively investigate how living cells interact with their environment to shape high-dimensional dynamics that could be used to generate a coherent temporal output,…
  preprints 2025 置信度 0.74
• A Comprehensive Benchmarking of Spatial Deconvolution and Domain Detection Methods across Diverse Tissues and Spatial Transcriptomic Technologies
  Abstract Spatial transcriptomic technologies enable high-resolution characterization of gene expression patterns and reconstruction of cellular architecture within tissue contexts. Two key computational problems have emerged for analyzing these datasets: spati…
  preprints 2026 置信度 0.74
• Yomix: An Interactive Tool for the Exploration of Low-Dimensional Embeddings in Omics Data
  Summary In the analysis of diverse omics data, a common and important preliminary step involves computing low-dimensional embeddings using techniques such as PCA, UMAP, t-SNE, or variational autoencoders. These embeddings provide a global overview of sample di…
  preprints 2025 置信度 0.74
• The Neuromorphic Conductor: A Speculative Framework for Brain-Chip Interfaces to Restore Bodily Function
  This report is a deep dive into the complex world of using neuromorphic chips to help people with severe brain damage regain control of their bodies. We’ll look at the fundamental science behind neuromorphic computing, explore the current landscape of brain-co…
  preprints 2025 置信度 0.74
• Cell Attention Networks Integrated with Spiking Neural Networks and Binary Light Spectrum Optimization for Efficient Task Scheduling in Cloud Computing: Blockchain-Enhanced
  Abstract Task scheduling in cloud computing remains a persistent and complex challenge due to inherently dynamic resource requirements and fluctuating workload patterns. Traditional methodologies—whether heuristic or AI-driven—often fall short in delivering re…
  preprints 2025 置信度 0.74
• scReady - an automated and accessible pipeline for single-cell RNA-Seq preprocessing: Empowering novice bioinformaticians
  The widespread adoption of single-cell RNA sequencing (scRNAseq) has democratized high-resolution transcriptomic analysis. Although data generation remains costly, many publicly available datasets can be leveraged to address focused research questions. However…
  preprints 2026 置信度 0.74
• Memristive Neuromorphic Vision: Spike-Timing Mechanisms for Visual-Tactile Perception
  Spike-timing mechanisms in neuromorphic vision sensors offer a state-of-the-art approach to replicating the efficiency and adaptability of biological visual systems. Leveraging memristor-based non-volatile memory, these sensors achieve high precision while mai…
  preprints 2025 置信度 0.74
• Large-scale classification of metagenomic samples: a comparative analysis of classical machine learning techniques vs a novel brain-inspired hyperdimensional computing approach
  Classical machine learning techniques have revolutionized bioinformatics, enabling researchers to extract knowledge from complex biological data. However, these techniques often struggle with high-dimensional data, where the increasing number of features leads…
  preprints 2025 置信度 0.74
• Radiation-Aware Meta-Plasticity (RAMP): A Bio-Inspired Learning Rule for Neuromorphic Computing in Radiation-Prone Environments
  Neuromorphic computing systems, particularly those based on spiking neural networks (SNNs), provide exceptional energy efficiency and real-time processing, making them attractive for space, nuclear, and high-energy physics (HEP) applications. Their deployment,…
  preprints 2025 置信度 0.74
• Visualizing biological shape differences
  Recent developments in morphometrics, the measurement of biological shape and shape change, are reviewed. After a roster of named, recognizably corresponding locations, or landmarks, have been located in each of a sample of images, the description of group dif…
  crossref F.L. Bookstein 2002-12-04T20:46:26Z 置信度 0.70
• AdPrST:An Adversarial Graph Deep Learning Pre-Clustering Framework for Deciphering Spatiotemporal Structures in Spatially Resolved Transcriptomics.
  Spatially Resolved Transcriptomics (SRT) has revolutionized our understanding of gene expression within tissue microenvironments, yet accurately deciphering spatiotemporal structures-encompassing spatial domain identification, trajectory inference, and pseudo-…
  europepmc 2026 置信度 0.80
• ABISS: An Open-Source, Low-Cost Platform for Auditory and Visual Intrinsic Optical Signal Imaging
  Defining the boundaries of functional cortical areas is increasingly important for targeted electro-physiology, optical imaging, viral delivery, and circuit manipulation. Intrinsic optical signal imaging (IOSI) provides a rapid and minimally invasive approach …
  europepmc 2026 置信度 0.80
• CRITERIA: A network decomposition and elementary flux mode translation-based tool for computing equilibria of biochemical systems.
  Analytically deriving equilibria, which often govern the long-term behavior of biochemical reaction networks, is essential for understanding cellular decision-making and robustness, yet remains computationally challenging for large and complex systems. The COM…
  europepmc 2026 置信度 0.80
• Interfacial Engineering of MoS<sub>2</sub> Thin Films for Wettability-Dependent Resistive Switching and Neuromorphic Behaviors.
  Recent years have witnessed a surge in the research of memristors as fundamental building blocks for neuromorphic computing, owing to their exceptional ability to emulate the plastic behavior of biological synapses in a high-density, low-power hardware format.…
  europepmc 2026 置信度 0.80
• An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.
  Fluid-structure interaction (FSI) simulation of biological systems presents significant computational challenges, particularly for applications involving large structural deformations and contact mechanics, such as heart valve dynamics. Traditional arbitrary L…
  europepmc 2026 置信度 0.80
• Graph identification of proteins in tomograms (GRIP-Tomo) 2.0: Topologically aware classification for proteins.
  Cryo-electron tomography (cryo-ET) enables structural characterization of biomolecules under near-native conditions. Existing approaches for interpreting the resulting three-dimensional volumes are computationally expensive and have difficulty interpreting den…
  europepmc 2026 置信度 0.80
• C─H Arylation-Derived Organic Conjugated Molecules for Optoelectronic Synaptic Transistors.
  Photonic organic field-effect transistors (OFETs) mimicking biological neurons hold great promise for neuromorphic computing. However, current organic optoelectronic materials still suffer from limited functionality and the low atom economy of conventional syn…
  europepmc 2026 置信度 0.80
• Water use efficiency in cereal crops: stomatal, hydraulic, biochemical mechanisms, and translational strategies for improvement.
  Water use efficiency in cereal crops is governed by molecular processes operating across biological scales that are connected imperfectly and non-linearly, from guard cell ion channel gating to canopy evapotranspiration. Despite the global urgency of improving…
  europepmc 2026 置信度 0.80
• Neural-network-inspired federated coordination for noise-tolerant distributed optimization in cyber-physical demand-side management.
  Introduction This study proposes a neural-network-inspired computational framework for hierarchical, noise-tolerant coordination in distributed agent networks. The framework is evaluated in a cyber-physical demand-side management testbed in which autonomous ho…
  europepmc 2026 置信度 0.80
• Amplification of computational power by the multiplication of bacteria exploring microfluidic networks encoding mathematical problems.
  Computational resources required for solving NP-complete problems grow exponentially with a polynomial increase in problem size. This exponentially increasing computational resource is runtime for sequential electronic computers and space for massively paralle…
  europepmc 2026 置信度 0.80
• The effect of treatment-induced resistance in a two-strain tuberculosis model with age structure and spatial diffusion.
  Tuberculosis (TB) is a highly contagious chronic infectious disease that, without timely intervention, can lead to severe health consequences or even death. Improper or incomplete treatment often induces the emergence of drug-resistant TB (DR-TB), which greatl…
  europepmc 2026 置信度 0.80
• Three-Dimensional Architecture of the Liver Structural Organization, Methodological Advances, and Functional Implications.
  Though comprising only 2-3% of body weight, the liver performs more than 500 distinct biochemical tasks, despite a parenchyma built almost entirely of hepatocytes-a single cell type that alone metabolizes carbohydrates, lipids, and proteins, synthesizes plasma…
  pubmed Siegelmann R, Litowczenko-Cybulska J, Gome G, Durak T 等 2026 Aug 13 置信度 0.82
• Development of an immunocompetent cutaneous squamous cell carcinoma model identifies VISTA and CTLA-4 as targetable immune checkpoints.
  Immunotherapeutic approaches for cutaneous squamous cell carcinoma (cSCC) remain limited to programmed cell death protein 1 (PD-1) blockade. Although genomics studies have characterized key driver mutations in cSCC, preclinical models that faithfully recapitul…
  pubmed Rodriguez Rosario AE, Rangel R Jr, Balbin N, Nizami ZN 等 2026 Aug 13 置信度 0.82
• Thermodynamic Constraints as Organizing Principles of Neural Efficiency and Cognitive Architecture.
  Biological neural systems sustain adaptive cognition under persistent and severe metabolic constraints. This paper develops a multi-scale thermodynamic framework in which those constraints function as organizing principles of neural efficiency and cognitive ar…
  pubmed Torres-Martínez S 2026 Aug 13 置信度 0.82
• Structure of an inhibitor bound to the catalytically important divalent metal ion site of afRioK1.
  Rio Kinase 1 (RioK1) is an anti-cancer target for colorectal cancer. In pursuit of selective inhibitors of RioK1, small drug-like molecules were identified using computer-aided drug design (CADD). CADD made use of a 3D crystal structure of human RioK1 bound to…
  pubmed Hunter DA, Yu W, Puranik P, Bannerjee A 等 2026 Aug 13 置信度 0.82
• Intact Cell Dissociation of FFPE Colon Tissue Enhances Cell Recovery and Gene Detection in scRNA-seq.
  pubmed Evans JR, Simmons AJ, Chen Z, Brown ME 等 2026 Aug 13 置信度 0.82
• Neural Selection in Corticothalamocortical Loops: Heterogeneity as a Computational Resource.
  Neuroscience has long relied on (typically binary) categorisations to manage the complexity of brain organisation. Yet growing anatomical and physiological evidence reveals that these dichotomies artificially partition systems that are inherently continuous an…
  pubmed Munn BR, Müller EJ, Whyte CJ, Brouwer T 等 2026 Aug 13 置信度 0.82
• The Roles of Biomedical Informatics for an Equitable Learning Health System: Lessons from a Year of Scientific Informatics Literature.
  Biomedical informatics plays a central role in supporting learning health systems (LHSs) which aim to continuously improve care by transforming data into knowledge and knowledge into action. However, healthcare data reflect existing disparities in access, deli…
  pubmed Islam H, Jayarman P, Reid N, Guckhool P 等 2026 Aug 13 置信度 0.82
• Uncertainty Quantification and Global Sensitivity Analysis of a Patient-Specific Mandibular Finite Element Model Using Latin Hypercube Sampling and Sparse Polynomial Chaos Expansion.
  Most mandibular finite element models are deterministic and overlook the influence of biological and modeling variability. This study proposes an automated, uncertainty-aware computational workflow for a patient-specific mandibular FE model using Latin Hypercu…
  pubmed Baugnon L, Nicot R, Bethune N, Lecomte-Grosbras P 等 2026 Aug 13 置信度 0.82
• Modeling microbiome modulation of tumor metabolic networks to predict synergistic therapies.
  Differences in microbiome composition profoundly influence drug response, yet methods to model the metabolic impact of microbes on host cells and therapeutics remain limited. We present a microbiome-aware computational framework combining machine learning and …
  pubmed Badenoch AJ, Pang Z, Chung CH, Robida A 等 2026 Aug 13 置信度 0.82
• Sensitivity analysis to isolate the effects of proteases and protease inhibitors on extracellular matrix turnover.
  Matrix metalloproteinases (MMPs) are a family of proteases that drive degradation of extracellular matrix (ECM) across many tissues. MMP activity is antagonized by tissue inhibitors of metalloproteinases (TIMPs), resulting in a complex multivariate system with…
  pubmed Yeganegi A, Robles K, Richardson WJ 2026 Aug 12 置信度 0.82
• Molecular characterization and biological characteristics of a highly pathogenic recombinant ALV-J strain (HUE2023) with cross-clade gp85 recombination.
  Avian leukosis virus subgroup J (ALV-J) has undergone extensive diversification into phylogenetically distinct clades, yet whether recombination between these clades within the gp85 envelope glycoprotein generates variants with altered pathogenicity has receiv…
  pubmed Li C, Tan Z, Tong L, Jiang Y 等 2026 Aug 10 置信度 0.82
• Frankenia hirsuta-derived biofunctionalized ZnO nanoparticles attenuate inflammation-associated tissue injury: Integrated pharmacological evaluation supported by network pharmacology and molecular docking.
  Inflammation-associated tissue injury is driven by complex interactions among inflammatory mediators, oxidative stress, and apoptosis, creating a need for therapeutic strategies capable of targeting multiple pathological processes. Plant-mediated zinc oxide na…
  pubmed Zokalih AH, El Hawary S, El Sayed AM, El Raey MA 等 2026 Aug 13 置信度 0.82
• Discovery of chromone-derived EGFR inhibitors as potent apoptosis inducers in cancer: In vitro and in vivo insights.
  Chromone derivatives are acknowledged as a privileged scaffold, recognized for their diverse pharmacological activities, including anti-cancer properties, although comprehensive investigations in this domain have been limited. This research addresses the desig…
  pubmed Elagamy A, Nafie MS, Elnahrawy A, Elsayed M 等 2026 Aug 10 置信度 0.82
• Identification of vaccine candidates by immunization with a complex pool of recombinant VLPs.
  Identifying the regions of a protein that can be readily translated into an effective vaccine remains a major challenge in epitope-focused vaccine design, especially when a protein is poorly characterized. Here, we describe an immune-driven strategy for epitop…
  pubmed Nepal Y, Wondra G, Jones DT, Francian A 等 2026 Aug 13 置信度 0.82
• Recent advances in cryoelectron tomography and applications to parasitology.
  Cryo-electron tomography (cryo-ET) has emerged as a transformative technique for visualizing the native ultrastructure of eukaryotic parasites, from proteins to cellular architecture. Recent technical advances in sample preparation, data collection, and comput…
  pubmed Coudray N, Ekiert DC, Bhabha G 2026 Aug 13 置信度 0.82
• Computational and artificial intelligence-guided discovery of potential therapeutic candidates targeting Ml0099 protein of Mycobacterium leprae.
  Despite a global decline in incidence, leprosy remains a major public health concern, with India accounting for over 55% of cases worldwide, highlighting the unmet need to characterize hypothetical proteins of M. leprae as novel therapeutic targets against eme…
  pubmed Shukla SK, Singh A, Kumar A 2026 Aug 11 置信度 0.82
• GCAN: A data feature learning method for scRNA-seq data.
  Single-cell RNA sequencing (scRNA-seq) data exhibit extreme sparsity, technical noise, and complex nonlinear structures that obstruct accurate biological interpretation. Current methods inadequately model intercellular relationships and suffer from feature sel…
  pubmed Bai J, Xu L 2026 Aug 7 置信度 0.82
• Multidimensional ejaculate-level variability in sperm quality in cynomolgus monkeys.
  Semen analysis in non-human primates is widely used for colony management, reproductive studies, and experimental design. However, variability in sperm quality across repeated ejaculates and its implications for semen interpretation remain insufficiently chara…
  pubmed Kim Y, Jo YJ, Youn C, You HJ 等 2026 Aug 13 置信度 0.82
• Design and synthesis of novel thiazolotriazole-sulfonamide hybrids tackling antimicrobial resistance: mechanistic insights into efflux pump inhibitor, gene downregulation, and machine-aided results.
  The escalating global threat of antimicrobial resistance necessitates innovative therapeutic strategies. In this study, a novel series of thiazolotriazole-sulfonamide hybrids was designed using a molecular hybridization strategy. Computational potency was pred…
  pubmed Elsayed HH, Elrazaz EZ, Jaballah MY, Hesham HM 等 2026 Aug 7 置信度 0.82
• Proximal Junctional Failure After Adult Spinal Deformity Surgery: A Systematic Review and Meta-analysis of Predictive Risk Factors.
  Systematic review and meta-analysis.
  pubmed Patel S, Nischal SA, White GW, Sarikonda A 等 2026 Aug 13 置信度 0.82
• Decoding the Deep: The Ecology, Biogeography, and Evolution of Deep-Sea Viruses.
  Viruses dominate the deep-ocean biosphere (>200-m depth) yet remain profoundly understudied. As the most abundant biological entities on Earth, they govern the geochemistry, evolution, and ecology of deep-sea prokaryotic and eukaryotic communities across a …
  pubmed Langwig MV, Anantharaman K 2026 Aug 13 置信度 0.82
• Effects of Stromal Cell-Derived Factor 1 on Osteoblast Activity During Orthodontic Tooth Movement.
  This study aimed to clarify the relationship between stromal cell‑derived factor 1 (SDF‑1) and osteoblast-related responses in periodontal ligament (PDL) during orthodontic tooth movement (OTM) after tooth extraction, based on the hypothesis that…
  pubmed Hamada Y, Ishida Y, Huang AC, Hamahara K 等 2026 Aug 置信度 0.82
• Comparative Analysis of the Mechanical and Biofilm Surface Formation of 3D Printed Resins and Milled PMMA Blocks With and Without Inorganic Fillers.
  Despite the growing number of studies assessing the performance of temporary restorative materials fabricated through CAD/CAM technologies, comparative analyses among 3D printed resins and milled PMMA blocks with differing compositions remain limited. This stu…
  pubmed Cerutti I, de Andrade JSR, Barboza ADS, Machado JB 等 2026 Aug 置信度 0.82
• Unraveling the molecular Nexus of Alzheimer's Disease and HIV encephalitis: The role of cellular senescence and transcriptional regulation.
  Alzheimer's disease (AD) and HIV-associated neurocognitive disorder (HAND) share progressive cognitive decline. Their common molecular mechanisms remain poorly understood. Current therapeutic approaches lack effective biomarkers for early diagnosis and interve…
  pubmed Zhang H, Chen W, Yuan S, Ding S 等 2026 置信度 0.82
• Shedding light on neural learning to rank models for anticancer drug prioritization.
  Learning to Rank (LeToR) methods have gained increasing attention in drug response prediction, offering a direct way to prioritize effective treatments for cancer cell lines. In this study, we systematically benchmark six ranking loss functions, including stat…
  pubmed Sarmeili F, Ghahremani-Nezhad B, Khalilpour M, Abbasi K 等 2026 置信度 0.82
• The effects of blast-induced traumatic brain injury on brain cellular mechanics and differentiation.
  Blast-induced traumatic brain injury (bTBI) causes significant disruptions in cellular and subcellular structures within the central nervous system (CNS) when an extremely large force is applied. The corresponding changes in biomechanical properties and cellul…
  pubmed Masud N, Fonder C, McGovern B, Hasib MHH 等 2026 置信度 0.82
• Integrating dynamic modeling of signaling pathways with subject-specific transcriptomic data to assess breast cancer risk.
  Breast cancer is the most common cancer in women and a leading cause of death. Traditional risk assessment models, such as the Gail model, lack molecular insight, limiting their usefulness for personalized prevention strategies. We developed a computational fr…
  pubmed Yamashita PR, Tangthanawatsakul A, Termsaithong T, Roshorm YM 等 2026 置信度 0.82
• An efficient ranking deep neural network algorithm for the prediction of Ca2+ binding sites of the protein.
  The Ca2+ binding sites of proteins are critical for their function, particularly in processes such as signal transduction, enzyme regulation, and structural stability. In this study, the calcium-binding sites of NtEhCaBP1 (Entamoeba histolytica calcium-binding…
  pubmed Parwekar P, Gourinath S, Jain J, Gundagatti S 等 2026 置信度 0.82
• Genome-wide machine learning analysis of anosmia and ageusia with COVID-19.
  The COVID-19 pandemic has caused substantial worldwide disruptions in health, economy, and society, manifesting symptoms such as loss of smell (anosmia) and loss of taste (ageusia), that can result in prolonged sensory impairment. Establishing the host genetic…
  pubmed Pietan L, Phillippi E, Melo M, El-Shanti H 等 2026 置信度 0.82
• Integrative bioinformatics analysis identifies gut microbiota-derived metabolite-associated immune candidate targets in high-risk primary biliary cholangitis.
  This study aimed to identify and prioritize gut microbiota-derived metabolite-associated host candidate targets in high-risk primary biliary cholangitis (PBC) through integrative multi-omics analysis and external validation.
  pubmed Feng J, Liu Z, Sun H 2026 置信度 0.82
• Temporal misalignment of renal sodium transport promotes non-dipping blood pressure phenotypes.
  Non-dipping blood pressure (BP) phenotypes are strongly associated with cardiovascular and renal morbidity, yet the physiological mechanisms governing nocturnal BP dipping remain incompletely understood. Experimental evidence suggests important roles for circa…
  pubmed Layton AT 2026 置信度 0.82
• Partition-Aware Joint Sparse Precision Matrix Estimation for Cancer Diagnosis.
  Precision matrices, which encode gene regulatory networks, play an important role for cancer diagnosis from transcriptomics data. Cancer subtypes often form partially related families that share regulatory structure to varying degrees, yet most multi-condition…
  pubmed Ahmed R, Jiang K, Chi W, Wu FX 2026 Aug 13 置信度 0.82
• Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody-Mediated Rejection.
  Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA+ patients do not develop AMR, raising the possibility of local tissue adaptati…
  pubmed Manion KP, Allen MA, Vincent A, Clotet-Freixas S 等 2026 Aug 13 置信度 0.82
• Large scale proteomic analyses of HR-pQCT-derived bone loss at the radius and tibia in older men.
  Although bone loss progresses rapidly in older adults, its biological drivers are poorly understood, and effective biomarkers are not available. We used large-scale discovery proteomics to identify serum proteins associated with bone loss, and to develop predi…
  pubmed Orwoll E, Wiedrick J, Ginsberg C, Lane NE 等 2026 Aug 13 置信度 0.82
• Integrated Phytochemical, Computational and In Vitro Evaluation of the Oocysticidal Activity of Pleurotus ostreatus Extract Against Cryptosporidium parvum.
  Cryptosporidiosis is a significant zoonotic parasite disease caused by Cryptosporidium parvum, impacting both humans and animals, with little therapeutic alternatives available. This work examined the phytochemical composition, antioxidant capacity, in silico …
  pubmed Marey AM, Dkhil MA, Kasem SM, Elabed S 等 2026 Aug 13 置信度 0.82
• Non-denaturing fluorescence in situ hybridization: a transformative tool for chromosome identification and engineering for crop improvement in the plant genomics era.
  This review highlights ND-FISH mechanisms, genomic integration, and workflows for karyotyping, rearrangement detection, and introgression, bridging cytogenetics and breeding for precision crop improvement. Fluorescence in situ hybridization (FISH) has been a p…
  pubmed Jiang C, Li G, Wan M, Yang E 等 2026 Aug 13 置信度 0.82
• Development and validation of an amyloid PET dementia of the Alzheimer's type (DAT) score.
  BackgroundAlzheimer's disease (AD) can be debilitating if left untreated, but its progression may be altered through early detection.ObjectiveTo develop and evaluate a convolutional neural network (CNN) for detecting AD from amyloid PET brain images and to inv…
  pubmed Edema M, Popuri K, Lee H, Wang L 等 2026 Aug 13 置信度 0.82
• AgPS3-Based Electrical Synapses with Tunable Multilevel Conductance for Noise-Robust Image Classification.
  Developing high-performance artificial synaptic electronics with novel functional materials is both crucial and challenging for the establishment of brain-inspired neuromorphic systems. Neuromorphic computing requires memristive devices with controllable condu…
  pubmed Zhan Z, Sun H, Li Y, Yang F 等 2026 Aug 13 置信度 0.82
• Nonuniform Distance Decay of Conductance in a Series of Multiheme Cytochrome Bioelectronic Junctions.
  Multiheme cytochromes have emerged as a promising new class of bioelectronic materials for potential use in soft and biocompatible electronics. To aid these developments it is essential to understand how conductance decays with increasing size of multiheme pro…
  pubmed Pethő AM, Futera Z, Blumberger J 2026 Aug 13 置信度 0.82
• P3BT Organic Memristor-Based Artificial Synapse for Neuromorphic Computing.
  Organic memristors have potential applications in simulating biological synapses for neuromorphic computing. In this work, a solution-processed Al/P3BT/indium tin oxide (ITO) organic memristor was designed. The device exhibits stable resistive switching behavi…
  pubmed Zhang H, Liu J, Shi R, Li W 等 2026 Aug 13 置信度 0.82
• How higher-order interactions shape the dynamics of large-scale dual-star neural networks.
  Understanding large-scale neural network dynamics represents a fundamental challenge in both biological and artificial neural systems. Traditional pairwise interaction models inadequately capture the complex connectivity patterns observed in real neural networ…
  pubmed Qiu Y, Xiao M, Sun Y, Ding J 等 2026 Aug 1 置信度 0.82
• Specificity of the Interactions of Folate-Based Vectors with Folate Receptor-α.
  The study explores the molecular-level binding of a set of vector ligands─folate, methotrexate, raltitrexed, pemetrexed, 5-methyltetrahydrofolate, and pteroyl ornithine─to the membrane-embedded folate receptor-α, a relevant target in cancer…
  pubmed Petkova J, Madjarova G, Vasilaki M, Gocheva G 等 2026 Aug 13 置信度 0.82
• How Functional Variants Reconfigure the Rac2 Conformational Landscape.
  Rac2, a member of the Rho family of small GTPases, is a fundamental regulator of essential cellular processes. Pathogenic substitutions near and within the Switch II region, specifically D57N and E62K, have been implicated in oncogenesis and immunodeficiency. …
  pubmed Haspel N, Jang H, Nussinov R 2026 Aug 13 置信度 0.82
• Novel 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, and biological evaluation as potent tubulin polymerisation inhibitors with anticancer activity.
  Microtubules assembled from α/β-tubulin heterodimers are critical for cell division and well-established anticancer drug targets, making tubulin polymerization inhibitors a viable route for new chemotherapeutics. Guided by structural analysis of co…
  pubmed Gao J, Zhang Y, Qu R, Xu Q 等 2026 Dec 置信度 0.82
• Antigen presentation requirements for effective cDC1-based cancer immunotherapy.
  Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated t…
  pubmed Pineda JE, Minowa T, Shen L, Zhou Y 等 2026 Aug 4 置信度 0.82
• Translation, sorting and enrichment: acoustic valve micro robotic system for multifunctional micro manipulation.
  The precise manipulation of micro-scale targets is a foundational technology driving advancements in biomedical engineering, clinical diagnostics, and micro-manufacturing. Here, we present a multifunctional acoustic valve microrobotic system capable of the pre…
  pubmed Qin X, Ouyang Y, Guo Z, Wang S 等 2026 Aug 13 置信度 0.82