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• Proteomic signatures of protected APOE ε4 carriers reveal causal pathways associated with delayed Alzheimer's disease onset.
  APOE ε4 is the strongest common genetic risk factor for Alzheimer's disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether protected ε4-first plasma proteomics could identify proteins associated with delayed…
  pubmed Le Guen Y, Park J, Peña-Tauber A, Greicius MD 2026 Aug 置信度 0.82
• Discovery of a potent TDP1 inhibitor through machine learning-driven predictive modeling combined with structure-based virtual screening and experimental validation.
  Tyrosyl-DNA phosphodiesterase I (TDP1) repairs topoisomerase I (TOP1)-mediated DNA damage and is a promising anticancer target, particularly in combination with TOP1 inhibitors. However, the discovery of potent and drug-like TDP1 inhibitors remains challenging…
  pubmed Zeng H, Zhang M, Qiu B, Zhang S 等 2026 Aug 12 置信度 0.82
• CIViC MCP: integrating large language models with the Clinical Interpretations of Variants in Cancer.
  The Clinical Interpretations of Variants in Cancer (CIViC) knowledgebase provides a community-driven, open-source platform for discussing the biological and clinical significance of molecular variants in cancer. Large language models (LLMs) offer a natural-lan…
  pubmed Schimmelpfennig L, Cody Q, McMichael JF, Coffman AC 等 2026 置信度 0.82
• Investigating Spatial Dynamics in Spatial Omics Data with StarTrail.
  Spatial omics technologies revolutionize our view of biological processes within tissues. However, existing methods fail to capture localized, sharp changes characteristic of critical events (e.g., tumor development). Here, we present StarTrail, a novel gradie…
  pubmed Chen J, Xiong C, Sun Q, Song Y 等 2026 Jul 7 置信度 0.82
• SNR-ST-Mix: sample-specific neighborhood regression mixup for augmented spatial transcriptomics imputation with deep neural network.
  Spatial transcriptomics (ST) enables gene-expression measurements within the tissue context. However, these measurements are often noisy, low-resolution, and sparsely sampled, which limits the recovery of fine spatial structure. Deep neural networks have becom…
  pubmed Yu H, Fang Y, Qian J, Wang X 等 2026 Jul 置信度 0.82
• Neonatal Brain Structure, Early Life Context, and Academic Achievement among Children Born Very Preterm.
  To examine whether neonatal brain abnormality severity was independently associated with academic achievement at 6 years and whether it modified the association between early life socioeconomic context and achievement in children born very preterm.
  pubmed Oftedal S, Bora S, Pannek K, Fiori S 等 2026 Oct 置信度 0.82
• Probing chemical space and conformational changes for subtype-selective orexin receptor antagonists.
  The orexin system, acting through OX1R and OX2R receptors, plays a key role in the regulation of sleep, motivation, and reward-related processes, making it a promising therapeutic target. While dual OXR antagonists are approved for the treatment of insomnia, t…
  pubmed Smith HR, Saab E, Green C, Addiah-Nickson JA 等 2026 Aug 12 置信度 0.82
• Perioperative pancreatic ductal adenocarcinoma care in 2025: who needs neoadjuvant?-who needs radiation?
  Despite advances in multimodal therapy, pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal tumor. For surgically resectable and borderline-resectable PDAC (BR-PDAC), the optimal integration of neoadjuvant chemotherapy and radiotherapy has yet to be…
  pubmed Sheng R, Wu Q, Lan K 2026 Jul 31 置信度 0.82
• Design, build and test of a targeted synthetic protein strategy.
  Incorporating minimal antibody regions into engineered proteins is an effective strategy for creating targeted therapeutics and diagnostics. However, a major barrier to clinical translation is the lack of efficient methods to track their performance in vivo . …
  pubmed Yallapragada VVB, Shukla A, Devoy C, Tangney M 2026 置信度 0.82
• Development and frontier trends of pancreaticojejunostomy over the past 26 years: bibliometric and visual analysis.
  Despite continuous advancements in pancreaticojejunostomy (PJ) techniques, there remains a lack of unified clinical guidelines for anastomosis selection. To date, bibliometric analysis has not yet been applied to systematically characterize the global developm…
  pubmed Cui X, Wang P, Jiang XZ, Zhou WH 等 2026 Jul 31 置信度 0.82
• Editorial: The future of oncology: digital twins and precision cancer care.
  pubmed Stahlberg E, Deng J, Hernandez-Boussard T, Wang Q 等 2026 置信度 0.82
• Systems toxicology integration uncovers trophoblast apoptosis as a pivotal mechanism underlying PFAS-related recurrent miscarriage.
  The present investigation seeks to clarify the molecular underpinnings through which perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) precipitate recurrent miscarriage (RM). Initially, prospective targets of PFOA (6050 in total) and PFOS (…
  pubmed Wu S, Dai W, Lin J, Hong X 2026 置信度 0.82
• Chemoinformatic and machine learning fusion for designing silver nanoparticles with enhanced antimicrobial properties.
  Predicting the antimicrobial efficacy of newly synthesized nanoparticles remains a complex and resource-intensive task. In this study, we present an interpretable machine learning framework for predicting the antimicrobial activity of silver nanoparticles (AgN…
  pubmed Yin H, Ahmed I, Howells C, Pervaiz S 等 2026 Sep 置信度 0.82
• Biology-aware scaling of microalgal biofuels: bioprocess constraints and data-centric digital twins.
  Microalgal biofuels remain a promising route for renewable fuel production, carbon utilization, wastewater valorization, and the development of a circular bioeconomy. However, their industrial deployment is still limited by the difficulty of translating labora…
  pubmed Correa-Aguado HC, Cerrillo-Rojas GV, Arzate-Cárdenas MA, Jaramillo-Martínez R 等 2026 置信度 0.82
• Modeling and targeting the hostile physicochemical niche in bone metastasis: from experimental platforms to niche-directed therapy.
  Cancer metastasis to bone is shaped not only by tumor-stromal crosstalk but also by a hostile physicochemical niche that promotes disease persistence and therapeutic failure. Hypoxia, acidosis, mineralized matrix architecture, altered mechanics, interstitial p…
  pubmed Bakir M, Alkhatib AR, Helal B, Al Masri MK 等 2026 置信度 0.82
• Baseline characteristics of the HOMINY (human papillomavirus, human immunodeficiency virus, and oral microbiota interplay in Nigerian youth) prospective longitudinal cohort.
  The HOMINY (Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth) cohort is a prospective longitudinal study established to investigate oral HPV infection and the oral microbiome among mother-child pairs with and …
  pubmed Juhlin E, Byrd MC, Jiang R, Gbolahan T 等 2026 置信度 0.82
• DFN-kcr: a dual-branch deep learning model with attention-guided fusion for predicting lysine crotonylation sites in human non-histone proteins.
  Lysine crotonylation (Kcr) is extensively present in human non-histone proteins and plays a critical regulatory role in essential biological processes, including cell signaling and metabolic regulation. However, conventional wet-lab approaches for Kcr site ide…
  pubmed Wei X, Hu S, Lin C 2026 置信度 0.82
• Peak alpha frequency is associated with pain severity in Long COVID patients with new-onset chronic pain.
  New-onset chronic pain is a common and debilitating symptom of Long COVID (LC) that remains not fully understood in terms of pathophysiology and therapeutic targets. A growing body of evidence in chronic pain syndromes similar to LC demonstrates an association…
  pubmed Silva-Passadouro B, Khoja O, Casson AJ, Delis I 等 2026 置信度 0.82
• AI-predicted zona pellucida binding: shortcut learning and clustered validation may overstate clinical portability.
  pubmed Wang T, Li Y, Tong R 2026 置信度 0.82
• AI without representation is just inequity at scale: on the exportation of unrepresentative artificial intelligence models to the Global South.
  pubmed Tinco Aliaga CA, Tan MJT, Hinostroza Fuentes VG, Abdul Karim H 等 2026 置信度 0.82
• Transcriptome sequencing and validation of potential biomarkers associated with cognitive impairment after hypertensive intracerebral hemorrhage.
  Hypertensive cerebral hemorrhage (HCH) accounts for the majority of spontaneous intracerebral hemorrhage (ICH) cases. Cognitive impairment (CI) is a major contributor to long-term disability following ICH, yet the molecular mechanisms underlying CI in hyperten…
  pubmed Tang Y, Yang B, Luo X 2026 置信度 0.82
• Targeted depletion of activated fibroblasts via [(177)Lu]Lu-FAPI radionuclide therapy ameliorates bleomycin-induced lung fibrosis.
  Fibroblast activation protein (FAP)-targeted radiopharmaceuticals have been widely applied in oncologic imaging and therapy, while their application in pulmonary fibrosis remains underexplored. This study investigated the biodistribution and therapeutic potent…
  pubmed Sun L, Li Z, Fang D, Zheng S 等 2026 置信度 0.82
• When prediction fails: a computational complexity view of stress.
  Living organisms are increasingly understood as predictive systems that anticipate near-future, fitness-relevant demands and proactively adjust physiology and behavior. Then, stress arises when environmental challenges exceed the range normally anticipated by …
  pubmed Budaev S, Lai F, Morgan R, Rønnestad I 2026 置信度 0.82
• Neuromorphic Devices and Computing for Sensing, Memory, and Control.
  Neuromorphic devices are bioinspired electronic systems that mimic key structures and functions of the nervous system, enabling integration and communication between living tissues and machines. This review examines how neuromorphic devices and computing are d…
  pubmed Zhu Z, Schaffer N, Yang X 2026 Aug 13 置信度 0.82
• Microneedle-Mediated Delivery of Extracellular Matrix-Inspired Peptides for Mitigation of Burn Wound Progression and Support of Tissue Repair.
  Topical treatment of burn wounds remains challenging because eschar formation, inflammation and impaired vascularization can limit drug penetration and tissue repair. Here, we introduce a flexible large-area microneedle patch for sustained local delivery of ex…
  pubmed Dos Santos DM, Nuutila K, Carlsson AH, Larson D 等 2026 Jul-Aug 置信度 0.82
• The parameter estimation tables (PEtab) format version 2.
  Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized …
  pubmed Pathirana D, Fröhlich F, Persson S, Bergmann FT 等 2026 Aug 13 置信度 0.82
• SBML level 3 package: flux balance constraints version 3.
  Constraint-based modeling is a well-established modeling methodology used to study biological networks at both the medium-scale and genome-scale. Due to their large size and complexity, such steady-state flux models are typically analyzed using constraint-base…
  pubmed Olivier BG, Bergmann FT, Keating S, König M 2026 Aug 13 置信度 0.82
• Unsupervised Annotation Transfer in Phase-Contrast Microscopy Using a CycleGAN.
  Domain shift between microscopy imaging domains poses a significant challenge for deploying deep learning-based cell detection models across different experimental setups. Manual annotation of new microscopy datasets remains resource-intensive and time-consumi…
  pubmed Al-Hamadani MNA, Hadjidemetriou S, Szeman-Nagy G, Skourides PA 等 2026 Aug 5 置信度 0.82
• Monocular Structured-Light Sensing for 3D Metallic Hole Measurement.
  Non-contact metric inspection of metallic circular holes is essential for assembly quality control, yet remains difficult on reflective machined surfaces, where depth scale, stripe radiometry, and contour geometry degrade simultaneously. Pure monocular two-dim…
  pubmed Lv Z, Chen L, Tian Y, Zhang X 等 2026 Aug 3 置信度 0.82
• Microtomographic Characterization of Morse-Tapered Implant Systems as Material-Biological Interfaces: Implications for Peri-Implant Soft Tissue Stability.
  Advanced dental implant systems are clinically successful when their material properties, surface topography, abutment geometry and implant-abutment connection design support both mechanical stability and biological integration. In Morse-tapered implant-abutme…
  pubmed Furlani M, Mortellaro C, Giuliani A 2026 Aug 3 置信度 0.82
• Flexible Neuromorphic Memristors: From Mechanisms to Applications.
  The von Neumann architecture, due to the physical separation between memory and processor, has limited the development of data-intensive applications. Neuromorphic computing technologies inspired by the brain's parallel and event-driven operation mechanisms ha…
  pubmed Yang L, Cheng J, Zhang Y, Wang Y 等 2026 Jul 30 置信度 0.82
• Toward an Integrated Strategy for Volumetric Muscle Loss Regeneration.
  Volumetric muscle loss (VML) constitutes a significant clinical challenge, defined by the irreversible loss of skeletal muscle tissue and resulting in persistent functional deficits due to fibrosis, chronic inflammation, and insufficient endogenous regeneratio…
  pubmed D'Costa C, Zhang KL, Duazo M, Grubišić V 等 2026 Jul 28 置信度 0.82
• Continuation Versus Discontinuation of Nonselective Beta-Blockers After Transjugular Intrahepatic Portosystemic Shunt Placement: A Real-World, Target-Trial Emulation Analysis.
  Background/Objectives : Nonselective beta-blockers (NSBBs) are foundational for variceal bleeding prophylaxis in cirrhosis. After transjugular intrahepatic portosystemic shunt (TIPS) placement, portal pressure is mechanically decompressed, and practice guidanc…
  pubmed Bardak AE, Bardak AI, Teker G, Naamani HE 等 2026 Jul 28 置信度 0.82
• In Vitro Anti-Breast Cancer Effects of Tamarix aphylla-Derived Quercetin and In Silico Insights into Its Targeting of PIP4K2A.
  Phosphatidylinositol 5-phosphate 4-kinase type 2 alpha (PIP4K2A) is a key oncogenic driver that regulates the PI5P/PIP2 axis to promote metastatic migration in breast cancer. This study aimed to investigate the therapeutic potential of a crude extract from Tam…
  pubmed Al-Fahad D, Hashim ZN, Almahmoud SA, Azam F 2026 Aug 6 置信度 0.82
• Broad-Spectrum Multi-Epitope Design Targeting Conserved Hantavirus Glycoproteins (Gn/Gc): Chimeric Antigen Engineering and Structural Mapping.
  Hantaviruses, the etiological agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), represent a high-risk zoonotic threat with substantial global health impact. Currently, there is no FDA-approved vaccine. The viral su…
  pubmed Fontes SDS, Conte FP, Fernandes J, Lemos ERS 等 2026 Aug 5 置信度 0.82
• Biostimulatory Effect of 3-Acetonyl-3-Hydroxyoxindole on the Growth and Secondary Metabolites of Khaya senegalensis: UPLC-MS/MS Profiling and Molecular Docking Insights.
  Developing sustainable agricultural biostimulants that simultaneously optimize vegetative growth and specialized metabolic pathways is critical for maximizing plant growth, photosynthetic efficiency, and metabolome reprogramming. In this study, for the first t…
  pubmed Mohamed AS, Chen Y, El-Sayed SM 2026 Aug 4 置信度 0.82
• Coronary Calcified Nodules: From Pathological Definitions to Intravascular Imaging- and Morphology-Guided PCI.
  Coronary artery calcification (CAC) is a hallmark of advanced atherosclerosis and a major determinant of procedural complexity during percutaneous coronary intervention (PCI). Once considered a passive consequence of vascular degeneration, CAC is now recognize…
  pubmed Lucki M, Iwańczyk S, Lucka E, Grygier M 等 2026 Aug 4 置信度 0.82
• A Generalizable and Interpretable Framework for Molecular Subtype Classification of Pancreatic Ductal Adenocarcinoma Integrating Conformal Uncertainty Quantification and Consensus-Based Explainable Artificial Intelligence Across Multiple Cohorts.
  Pancreatic ductal adenocarcinoma (PDAC) has two principal molecular subtypes-classical and basal-like-with divergent prognosis and chemotherapy response, yet transcriptomic classifiers rarely generalize across cohorts or quantify per-patient uncertainty. We tr…
  pubmed Yasar S, Yagin FH, Alzakari SA, Alkhalifa AK 等 2026 Aug 4 置信度 0.82
• Chromatin Accessibility-Guided Targeting Identifies Structurally Constrained Regions in HBV cccDNA and Suppresses Viral Replication.
  Covalently closed circular DNA (cccDNA) is a stable episomal form of the hepatitis B virus (HBV) genome that serves as the template for viral transcription and replication and represents a major barrier to HBV cure. Here, we investigated chromatin accessibilit…
  pubmed Kong L, Iwabuchi S, Li YY, Murai K 等 2026 Aug 3 置信度 0.82
• Conserved Core and Species-Specific Signatures in the Milk Exosomal microRNA Targetome: A Preliminary Comparative In Silico Analysis of Human, Cow, Goat and Donkey Milk.
  Milk-derived extracellular vesicles (EVs) transport microRNAs (miRNAs) that are unusually stable and have been proposed to survive digestion and modulate gene expression in the consumer, although their dietary bioavailability and physiological relevance remain…
  pubmed Zoziuk M, Djibagaou AD, Terrinoni A, Koroliouk D 等 2026 Aug 2 置信度 0.82
• Short-Read NGS of a Long-Range CYP21A2 Amplicon as an Improved Alternative to Sanger Sequencing for Congenital Adrenal Hyperplasia Genetic Testing.
  The standard-of-car and genetic testing for 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) is Sanger sequencing of a long-range CYP21A2 amplicon combined with multiplex ligation-dependent probe amplification (MLPA). Many Sanger sequencing proto…
  pubmed Antysheva Z, Bogdanov V, Rutkovskaya E, Stepanova A 等 2026 Aug 2 置信度 0.82
• CellSwarm-AD: A Multi-Scale Agent-Based Framework for Virtual Alzheimer's Disease Trials.
  Computational models of Alzheimer's disease (AD) rarely connect cellular heterogeneity, spatial tissue organization, pathology cascades, and pharmacological intervention within one auditable workflow. We present CellSwarm-AD, a four-layer framework comprising …
  pubmed Tan CL, Zheng XM, Zhu YF, Xiong QQ 等 2026 Aug 1 置信度 0.82
• Exploring the α-Glucosidase Inhibitory Activity of Bioactive Compounds from Persicaria odorata (Lour.) Extracts via Integrated In Vitro and In Silico Studies.
  Persicaria odorata (Lour.) contains considerable amounts of phytochemicals, including phenolics and essential oils, which have been reported to inhibit α-glucosidase activity. However, which bioactive compounds play a key role in inhibiting the α-g…
  pubmed Subhan M, Sanachai K, Nutho B, Ratha J 等 2026 Aug 1 置信度 0.82
• Whole-Cell Transformation of Cannabidiol by Selected Filamentous Fungi into Novel Polar Derivatives.
  Cannabidiol (CBD) is a bioactive phytocannabinoid with considerable pharmacological potential. However, its limited aqueous solubility and high lipophilicity remain significant barriers to its broader pharmaceutical application. In this study, the enzymatic po…
  pubmed Łój D, Janeczko T, Bromke MA, Tronina T 2026 Aug 1 置信度 0.82
• Genome-Wide Dissection of the TCP Gene Family in Peach and Expression Analysis Under Drought Stress.
  The TCP ( Teosinte branched 1/ Cycloidea/Proliferating ) gene family comprises plant-specific transcription factors essential for regulating growth, development, and environmental adaptation. Utilizing the high-quality 'Rui Youpan 1' ('RYP1') reference genome,…
  pubmed Jing Y, Yu Y, Xiao Z, Xu Y 等 2026 Jul 30 置信度 0.82
• A Hierarchical Multimodal Knowledge Graph for Neural Cell-Type-Specific Regulation Integrating Single-Cell Transcriptomics and Literature Evidence.
  The nervous system comprises highly diverse cell types governed by cell-type-specific molecular regulatory programs. However, regulatory evidence is scattered across unstructured literature and described using inconsistent cell-type nomenclature and granularit…
  pubmed Chen C, Ni X, Min Y, Wang Z 等 2026 Jul 30 置信度 0.82
• Mathematical and Computational Models of Biochemical Reactions and Cell Signaling-From Ordinary Differential Equations to Machine Learning.
  Cell signaling, and the biochemical reactions underlying it, are complex phenomena fundamental for control of cellular behavior in response to the incentives present in the cell's direct environment. It is crucial for coordination of cell activities such as gr…
  pubmed Matyszczak G 2026 Jul 30 置信度 0.82
• Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical.
  Autophagy-lysosome dysfunction accompanies dermal fibroblast ageing, yet whether remodelling is transcriptional or post-transcriptional in primary human cells remains unresolved. We reanalysed the Genetic and Epigenetic Signatures of Translational Ageing Labor…
  pubmed Cai M, Xu M 2026 Jul 29 置信度 0.82
• IgE Occupancy and Antigen Valency Cooperate to Control FcεRI Aggregation Geometry and Signaling Efficiency.
  The crosslinking of IgE-bound FcεRI by multivalent allergens initiates mast cell and basophil signaling underlying Type 1 allergy. Yet, how allergen properties and IgE occupancy impact receptor aggregation and downstream signaling remains unclear. We use…
  pubmed Linhart B, Grattan RM, David JC, Jhamba ED 等 2026 Jul 28 置信度 0.82
• Rare AFG3L2 and POLG Variants Suggest a Role for Mitochondrial Dysfunction in Enteric Neuronal Vulnerability in Idiopathic Achalasia.
  Idiopathic achalasia is a rare esophageal motility disorder characterized by the selective degeneration of inhibitory myenteric neurons. Its genetic basis remains poorly defined. We investigated whether rare coding variants may contribute to disease susceptibi…
  pubmed Latiano A, Tavano F, Micale L, Bisceglia L 等 2026 Jul 28 置信度 0.82
• Artificial Intelligence and Genomic Data Analysis: New Frontiers in Precision Medicine.
  The rapid expansion of next-generation sequencing technologies has generated unprecedented volumes of genomic data; however, translating these data into reliable and clinically actionable insights remains a major challenge in precision medicine. Artificial int…
  pubmed Blaga AM, Mihuț RO, Treteanu AR, Andronic O 等 2026 Jul 28 置信度 0.82
• Dose-Dependent Influence of RBD-Derived Amyloidogenic Peptides on SARS-CoV-2 Infectivity: A Cautionary Tale for Antiviral Design.
  The receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein remains a central target for antiviral drug development. Recent in silico studies have revealed an expansion of amyloidogenic regions within the RBD of the Omicron variant, raising the possibili…
  pubmed Nikiforova MA, Grishin SY, Aksenova AY, Deryusheva EI 等 2026 Jul 28 置信度 0.82
• Discovery and Comprehensive Characterization of Pseudomonas sp. MUP55: Taxonomy, Massetolide-Mediated Biocontrol, and Regulatory and Antimicrobial Contributions of the pvf Cluster.
  Pseudomonas sp. MUP55, isolated from rainfall water in Western Australia, was characterized by polyphasic taxonomy and functional assays. Whole-genome and 16S rRNA phylogeny placed Pseudomonas sp. MUP55 in the Pseudomonas fluorescens species group. Massetolide…
  pubmed Alattas H, Sala S, Boctor J, Young CE 等 2026 Jul 28 置信度 0.82
• Bovine In Vitro Fertilization Embryo Development Predicted by Capacitation-Induced Zinc Ion Flux and Acrosome Remodeling.
  Sire-dependent variation in bovine in vitro fertilization (IVF) success is poorly explained by conventional semen parameters once samples meet standard quality thresholds. Sperm capacitation is required for acquisition of fertilization competence, yet its cont…
  pubmed Jimmerson K, Jahnke M, Keller E, Putz A 等 2026 Jul 28 置信度 0.82
• NEUROTECH - A European Community of Experts on Neuromorphic Technologies
  Neuromorphic Computing Technology (NCT) is becoming a reality in Europe thanks to a coordinated effort to unite the EU researchers and stakeholders interested in neuroscience, artificial intelligence, and nanoscale technologies. Artificial intelligence (AI) ha…
  datacite Payvand, Melika, Donati, Elisa, Indiveri, Giacomo 2021 置信度 0.66
• Unlocking the Roots of Disease with Quantum Mechanics… The Prelude to 'Quantum Medicine', a New Paradigm in Precision Medicine
  • Published in the international journal Clinical and Translational Medicine, reinterpreting redox biology and disease mechanisms from a quantum-mechanical perspective. • Identified that electron tunneling, proton-coupled electron transfer (PCET), and spin-sel…
  datacite inquantio 2026 置信度 0.66 quantum biology
• V3-Apoptosis-Simulator: High-Integrity Formal Verification and Deterministic Predictive Modeling of Cell Death Cascades using Ada/SPARK
  Abstract: This repository introduces a novel computational framework for the high-integrity simulation of cellular apoptosis, built upon the V3 architecture using the Ada/SPARK 2014 formal verification language. Traditional biological simulations (often writte…
  datacite benhadid, outail 2026 置信度 0.66 Ada/SPARK, Formal Verification, Run-time Exception Freedom, Absence of Exceptions (AoE), Deterministic Simulation, Multi-module Architecture, Systems Biology, Computational Oncology, Apoptosis Pathway, Bcl-2/Bax Signaling, Predictive Medicine, In Silico Oncology, Pre-clinical Drug Screening, Software Engineering, Mathematical Integrity, Digital Root
• Reproducibility Package for "Recoverability of the H2AT Stabilizing Input from Sitting Kinematics: A Model-Based Validity Analysis for Spinal Cord Injury"
  This reproducibility package supports the manuscript “Recoverability of the H2AT Stabilizing Input from Sitting Kinematics: A Model-Based Validity Analysis for Spinal Cord Injury,” submitted to Medical & Biological Engineering & Computing. The record contains …
  datacite Hoang, Vinh Sinh 2026 置信度 0.66 H2ATspinal cord injurysitting biomechanicsinverse dynamicsmeasurement uncertainty
• How is the Way to Resurrect the Dead? Defining a Quantum Framework Based on Information Processing and State Preparation
  Introduction and Problem Statement The ultimate biological and physical barrier to the concept of resurrecting deceased individuals is the dilemma of "informational entropy". Post-mortem, the neural and informational patterns that once constituted a person's i…
  datacite Rahimi, Ehsanullah 2026 置信度 0.66 Quantum MechanicsConsciousnessNo-Cloning TheoremResurrecting
• A Unified Framework for Joint Detection of Lacunes and Enlarged Perivascular Spaces
  Cerebral small vessel disease (CSVD) markers, specifically enlarged perivascular spaces (EPVS) and lacunae, present a unique challenge in medical image analysis due to their radiological mimicry. Standard segmentation networks struggle with feature interferenc…
  datacite He, Lucas, Li, Krinos, Zhang, Hanyuan, He, Runlong 等 2026 置信度 0.66 Computer Vision and Pattern Recognition (cs.CV)FOS: Computer and information sciences
• Input-to-state stability of chemical reaction networks with application to molecular computation
  In biological reaction systems, reaction rates may vary over time due to environmental fluctuations, regulation, or coupling with other reaction modules. Input-to-state stability (ISS) provides a useful tool for analyzing the robustness of time-varying chemica…
  datacite Jiang, Renlei, Zhang, Xiaoyu, Gao, Chuanhou, Dochain, Denis 2026 置信度 0.66 Dynamical Systems (math.DS)FOS: Mathematics
• A Bayes-Markov Neuromorphic Model of Cortical Orientation Selectivity: A Computational Re-implementation and Quantitative Simulation Study
  The emergence of orientation selectivity in the primary visual cortex (V1) remains a central question in computational neuroscience. Shirazi's Bayes-Markov model proposed a probabilistic explanation for how orientation-selective inhibition can arise from non-o…
  datacite Moslemi, Abolfazl, Sarabadani, Milad, Sefidian, Fatemeh, Peyvandi, Hossein 2026 置信度 0.66 Neurons and Cognition (q-bio.NC)Machine Learning (cs.LG)Neural and Evolutionary Computing (cs.NE)FOS: Biological sciencesFOS: Computer and information sciences
• The New Emperor: Consciousness, Oxymetamorph, Quantum Game Theory, Birth of Time & the GPC
  The New Emperor: Consciousness, Oxymetamorph, Quantum Game Theory, Birth of Time & the GPC Definition(s): Consciousness is the Calibration of a field that uses Relational Reductionism to generate a Camouflage of distinct, directional dynamism, purely to surviv…
  datacite Alam, Md Jahangir 2026 置信度 0.66
• THE ARCHITECTURE OF DECOHERENCE: Biological Qubits, Thermodynamic Friction, and the HEPOE Limit in Quantum Computing
  ABSTRACT The pursuit of quantum supremacy is currently bottlenecked not merely by engineering constraints, but by the fundamental thermodynamic limits of error correction and decoherence. While contemporary hardware engineering approaches this instability prim…
  datacite Brezolin de Freitas, Sidnei, Leão de Matos Brezolin, Camila 2026 置信度 0.66
• A Theoretical Framework for Monolithic Neural–Computational Integration at the Quadrillion-Parameter Scale
  This paper proposes the Singularity Implant (SI), a theoretical framework for the integration of brain–computer interfaces, neuromorphic computing, and extremely large artificial intelligence models within a future intracranial computational platform. The prop…
  datacite Revista, Zen 2026 置信度 0.66
• The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
  GeneMANIA (http://www.genemania.org) is a flexible, user-friendly web interface for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Given a query list, GeneMANIA extends the list with functionally s…
  openalex David Warde-Farley, Sylva L. Donaldson, Ovi Comes, Khalid Zuberi 等 2010-06-21 置信度 0.72 BiologyFunction (biology)Model organismOrganismComputer science
• The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz
  Three experimental techniques based on automatic swept-frequency network and impedance analysers were used to measure the dielectric properties of tissue in the frequency range 10 Hz to 20 GHz. The technique used in conjunction with the impedance analyser is d…
  openalex Sami Gabriel, R W M Lau, Camelia Gabriel 1996-11-01 置信度 0.72 AnalyserDielectricRange (aeronautics)Electrical impedanceMaterials science
• X-ray-Computed Tomography Contrast Agents
  ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTX-ray-Computed Tomography Contrast AgentsHrvoje Lusic and Mark W. Grinstaff*View Author Information Departments of Biomedical Engineering and Chemistry, Metcalf Center for Science and Engineering, Boston University, 5…
  openalex Hrvoje Lusic, Mark W. Grinstaff 2012-12-05 置信度 0.72 CitationCommonwealthComputed tomographyContrast (vision)Computer science
• Methods for Molecular Recognition Computing
  The softmax attention mechanism in transformer architectures (Vaswani et al., 2017) is mathematically identical to the Boltzmann distribution governing molecular binding at thermal equilibrium (Boltzmann, 1877). Luce's Choice Axiom (1959) establishes this func…
  preprints 2026 置信度 0.74
• eQTM (expression quantitative trait methylation) Atlas: a comprehensive resource of over 11 million DNA methylation–gene expression associations through across 11 tissues and 4 diseases
  Motivation Epigenome-wide association studies (EWAS) have identified numerous DNA methylation (DNAm) CpG sites associated with complex traits and diseases, but interpretation of those CpG sites remains challenging because in EWAS, CpGs are mostly linked to nea…
  preprints 2026 置信度 0.74
• A reconfigurable DNA memory architecture for hierarchical data management via programmable phase transitions
  DNA has emerged as a promising medium for the post-silicon era of information storage due to its ultrahigh density and longevity. However, current systems are bifurcated, with solid-state systems providing robust cold archival but lacking accessibility, while …
  preprints 2026 置信度 0.74
• Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations
  Identifying the genetic changes that shaped recent human adaptation depends on our ability to detect selection from genomic data. Summary statistics from haplotype scans have been widely used for that purpose, aggregating genetic signal over windows, though re…
  preprints 2026 置信度 0.74
• The D4Z4caster DNA methylation signature identifies individuals at epigenetic risk for developing facioscapulohumeral muscular dystrophy (FSHD)
  Background Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic dysregulation at the chromosome 4q35 D4Z4 repeat array under specific permissive genetic conditions. Due to the complexity, expense, and general inaccessibility of FSHD genetic te…
  preprints 2026 置信度 0.74
• CBIcall: a configuration-driven framework for variant calling in large sequencing cohorts
  Motivation Variant calling for next-generation sequencing (NGS) data relies on a diverse ecosystem of tools and workflows. Large-scale collaborative studies increasingly adopt federated analysis, where each institution processes sensitive data locally using st…
  preprints 2026 置信度 0.74
• Quantifying and Predicting the Difficulty of Multiple Sequence Alignment with AlDiScore
  Multiple Sequence Alignment (MSA) constitutes an important and frequent operation in molecular sequence data analysis. There exist numerous tools, algorithms, and criteria to infer an MSA. This plethora of available approaches to MSA may induced an ensemble of…
  preprints 2026 置信度 0.74
• Quaternion Spectral Fingerprinting of DNA: GPU-Accelerated Multi-Channel Fourier Analysis for Alignment-Free Genomics
  Spectral methods for DNA sequence analysis—treating genomic data as a discrete signal and computing its Fourier transform—were proposed over three decades ago but remained impractical for whole-genome analysis due to computational cost. We present a quaternion…
  preprints 2026 置信度 0.74
• GeneCAD: Plant Genome Annotation with a DNA Foundation Model
  Accurate genome annotation is fundamental to biological discovery, yet identifying gene structures directly from DNA sequence remains a major challenge in complex genomes. We introduce GeneCAD, a sequence-only framework that predicts biologically coherent gene…
  preprints 2025 置信度 0.74
• BioPipelines: Accessible Computational Protein and Ligand Design for Chemical Biologists
  Deep learning methods for protein structure generation, sequence design, and structure and property prediction have created unprecedented opportunities for protein engineering and drug discovery. However, using these tools often requires navigating incompatibl…
  preprints 2026 置信度 0.74
• Particle Biology: A Perspective on a First-Principles Theory of Life
  This Perspective formally proposes Particle Biology as a unifying theoretical framework to address the critical bottleneck in current life science research. Current life science research has reached a critical bottleneck. While the field has advanced to the st…
  preprints 2026 置信度 0.74
• MOAflow: how re-design a pipeline with Nextflow streamlines data analysis
  Background Advances in high-throughput DNA sequencing technologies have dramatically reduced the time and cost required to generate genomic data. As sequencing is no longer a limiting factor, increasing attention must be paid to optimizing the analyses of the …
  preprints 2026 置信度 0.74
• Open-source, Hardware-Independent GPU Acceleration for Scalable Nanopore Basecalling with Slorado and Openfish
  Nanopore sequencing technologies are used widely in genomics research and their adoption continues to accelerate. ‘Basecalling’ is an essential step in the nanopore sequencing workflow, during which raw electrical signals are translated into nucleotide sequenc…
  preprints 2026 置信度 0.74
• Scalable computation of ultrabubbles in pangenomes by orienting bidirected graphs
  Motivation Pangenome graphs are increasingly used in bioinformatics, ranging from environmental surveillance and crop improvement to the construction of population-scale human pangenomes. As these graphs grow in size, methods that scale efficiently become esse…
  europepmc 2026 置信度 0.80
• Structural Recomputation Framework: A Deterministic Execution Abstraction for Memory-Constrained Dynamic Programming in Bioinformatics
  Abstract Dynamic programming (DP) algorithms are foundational to bioinformatics, yet their application to genomic-scale data is frequently constrained by a quadratic memory bottleneck. This storage requirement primarily arises from the necessity of persisting …
  preprints 2026 置信度 0.74
• A Hybrid Image Encryption Framework Combining Feedback DNA and Chaotic Maps for Improved Security in Cloud Storage
  Securing sensitive visual data, such as medical images, classified surveillance or reconnaissance data, and personal multimedia, requires specialized encryption systems in the age of pervasive digital communication and cloud computing environments. Digital ima…
  preprints 2025 置信度 0.74
• What makes a banana false? How the genome of Ethiopian orphan staple Ensete ventricosum differs from the banana A and B sub-genomes
  Abstract Background Ensete ventricosum , also known as the “tree against hunger” plays a key role in Ethiopian food security and farming systems, feeding more than 20 million people. Since domestication via clonal selection in the south-west Ethiopian highland…
  preprints 2026 置信度 0.74
• MirAge, a novel Matrix Analyzer for fast DNA classification
  Summary To understand the composition of metagenomics samples, fast computer tools analyze large datasets to compose a taxonomic overview. With large datasets, it is still a challenge to achieve high precision and sensitive results in fast manner. Here we show…
  preprints 2025 置信度 0.74
• Natural Observation-Based Computing: A Novel Paradigm for Solving Computational Problems Through Structural Learning
  We introduce Natural Observation-Based Computing (NOBC), a fundamentally new computational paradigm that solves optimization problems through direct observation and structural learning rather than algorithmic search. Unlike traditional approaches that require …
  preprints 2025 置信度 0.74
• HapBridge: A Methylation-Guided Approach for Correcting Switch Errors and Bridging Phased Blocks in Long-Read Phasing
  Long-read sequencing has substantially advanced haplotype phasing yet continues to face challenges in low-heterozygosity regions and switch errors caused by read noise. DNA methylation exhibits haplotype-specific patterns, providing complementary linkage infor…
  preprints 2025 置信度 0.74
• PlantCAD2: a DNA foundation model for interpreting genomes across flowering plants
  Understanding how DNA sequence encodes biological function remains a fundamental challenge in biology. Flowering plants (angiosperms), the dominant terrestrial clade, exhibit maximal biochemical complexity, extraordinary species diversity (over 100,000 species…
  preprints 2025 置信度 0.74
• HORDCOIN: A Software Library for Higher Order Connected Information and Entropic Constraints Approximation
  Background and objective Quantifying higher-order statistical dependencies in multivariate biomedical data is essential for understanding collective dynamics in complex systems such as neuronal populations. The connected information framework provides a princi…
  preprints 2026 置信度 0.74
• Guess till correct: Gungnir codec enabling high error-tolerance and low-redundancy DNA storage through substantial computing power
  DNA has emerged as a compelling archival storage medium, offering unprecedented information density and millennia-scale durability. Despite its promise, DNA-based data storage faces critical challenges due to error-prone processes during DNA synthesis, storage…
  preprints 2025 置信度 0.74
• Leveraging DNA-Based Computing to Improve the Performance of Artificial Neural Networks in Smart Manufacturing
  Bioinspired computing methods, such as Artificial Neural Networks (ANNs), play a significant role in machine learning. This is particularly evident in smart manufacturing, where ANNs and their derivatives, like deep learning, are widely used for pattern recogn…
  preprints 2025 置信度 0.74
• GeneF: A High-Performance Processing-in-Memory Accelerator for Efficient DNA Alignment
  In this paper, we explore the compute and memory characteristics of the FM-index and identify data movement as a significant contributor to overall energy consumption in genomic processing. We propose GeneF, a Processing-in-Memory (PIM) accelerator designed sp…
  preprints 2025 置信度 0.74
• RawBench: A Comprehensive Benchmarking Framework for Raw Nanopore Signal Analysis Techniques
  Nanopore sequencing technologies continue to advance rapidly, offering critical benefits such as real-time analysis, the ability to sequence extremely long DNA fragments (up to millions of bases in a single read), and the option to selectively stop sequencing …
  preprints 2025 置信度 0.74
• A Thermodynamically Favoured Molecular Computer: Robust, Fast, Renewable, Scalable
  Like life, computers are out-of-equilibrium. 1,2 Thermodynamically favoured error states are thwarted by energetically-costly processes such as kinetic proofreading of biological polymers, error-correcting codes in computer data storage, and redundancy in mole…
  preprints 2025 置信度 0.74
• Oyster: a neural network for modelling genomic sequences that enables exact position-specific <i>k</i> -mer contributions
  Genomic functions arise from nucleotide sequences and their overlapping k -mers – subsequences whose contributions depend on their composition, position and associations. Understanding these contributions requires computing a k -mer contribution function that …
  preprints 2025 置信度 0.74
• Assembly Theory - Formalizing Assembly Spaces, Discovering Patterns and Bounds
  Assembly theory defines structural complexity as the minimum number of steps required to construct an object in an assembly space. We formalize the assembly space as an acyclic digraph of strings. Key results include analytical bounds on the minimum and maximu…
  preprints 2025 置信度 0.74
• The role of Mediterranean diet adherence, smoking and their interactions in epigenetic age acceleration: A cross-sectional analysis of the Airwave cohort
  ABSTRACT Background Epigenetic clocks are markers of biological aging that may vary in their sensitivity to environmental stressors and lifestyle modifiers. To evaluate the utility of these biomarkers as sensors of the human exposome, we investigated how they …
  preprints 2026 置信度 0.74
• Expanding the RNA Virus Universe by Scalable Structure-Guided Discovery
  The discovery of RNA viruses from metatranscriptomic data remains challenging due to their extreme sequence divergence and frequent lack of conserved motifs. We present Rider, a lightweight two-stage framework that couples fast, structure-informed sequence scr…
  preprints 2025 置信度 0.74
• Adverse Effects of UV-Exposure on DNA Strand Displacement Reactions
  DNA strand displacement (DSD) reactions are widely used in molecular computing and nanotechnology due to their programmability and precise control over molecular interactions. However, experimental DSD systems often underperform relative to theoretical models,…
  preprints 2025 置信度 0.74