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• Moments of the length of sample genealogy and their applications ☆
  Underlying many important statistical properties of a sample of DNA sequences is the total branch length L of the sample’s genealogy. A classic example is the number K of mutations on the genealogy, whose expectation and variance are simple functions of the ex…
  preprints 2025 置信度 0.74
• Environmental determinants of Parkinson’s disease and attributable burden in Latin America
  Abstract We investigated environmental determinants of Parkinson’s disease (PD) and their attributable burden in a case-control study of 9,887 participants from nine Latin American countries. Logistic regression adjusted for age, sex, and country estimated ass…
  preprints 2026 置信度 0.74
• Dynamic sedimentary ancient DNA models of Fennoscandic Holocene plant communities reveal the role of temperature and competition
  Ecosystems are constantly responding to shifting environmental conditions, and the observed structure of ecological communities at any given discrete observation timepoint is part of a larger dynamic response. However, we lack long-term time series of ecosyste…
  preprints 2026 置信度 0.74
• Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood
  Whether and how genetic regulation of DNA methylation (DNAm) change across the lifespan remains unclear. Here, we map age-dependent methylation quantitative trait loci (longitudinal mQTLs) using linear mixed models applied to repeated blood DNAm measures from …
  preprints 2026 置信度 0.74
• Associations between Elevated Circulating Amino Acid Levels and Brain Health: A Mendelian Randomization Study in the UK Biobank
  Background previous research has demonstrated a relationship between chronically elevated postabsorptive amino acid (AA) levels and the pathophysiology of neurological disorders such as dementia. It is unclear if some of these associations are causal or second…
  preprints 2026 置信度 0.74
• A Modular Fusion Neural Network Approach to Efficiently Predict Multi-Metal Binding Sites in Protein Sequences
  Accurate identification of metal-binding residues is essential for the study of metalloproteins, like zinc finger proteins, haemoglobin, and DNA polymerase. Due to the high cost and time demands of experimental methods, computational prediction has been applie…
  preprints 2025 置信度 0.74
• Intelligence of Matter: Rise of a New Style of Doing Science and Scientific Thinking?
  From Galileo’s conviction that the Universe is written in the language of mathematics to the genomic and computational revolutions of the twentieth century, science has long sought to describe nature through external symbolic systems. However, mounting evidenc…
  preprints 2025 置信度 0.74
• Large scale phage-antibiotic combination studies reveal key combinations for urinary tract infection and urosepsis treatments
  Abstract The growing problem of AMR infections in healthcare has prompted the search for alternative treatments, with increasing interest in bacteriophages. However, most bacteriophage-antibiotic interactions are incompletely understood, and the benefits of co…
  preprints 2026 置信度 0.74
• Limited genetic structure and high gene flow in <i>Fasciola hepatica</i> populations infecting ruminants in different geographic areas in the UK
  The liver fluke, Fasciola hepatica , is a major parasitic threat to ruminant health and productivity worldwide, with important implications for food security, animal welfare, and zoonotic risk. This study developed and validated a multiplex deep amplicon seque…
  preprints 2026 置信度 0.74
• SNAP: Streamlined Nextflow Analysis Pipeline for Immunoprecipitation-Based Epigenomic Profiling of Circulating Chromatin
  Epigenomic profiling of circulating chromatin is a powerful and minimally invasive approach for detecting and monitoring disease, but there are no bioinformatics pipelines tailored to the unique characteristics of cell-free chromatin. We present SNAP (Streamli…
  preprints 2025 置信度 0.74
• <i>demografr</i> : A toolkit for simulation-based inference in population genetics
  Simulation-based inference methods such as Approximate Bayesian Computation (ABC) are a popular class of techniques in evolutionary biology and population genetics. These methods are particularly useful for fitting complex models, as they can bypass the need t…
  preprints 2025 置信度 0.74
• Recoding Genomic Elements with AI and Quantum Computation to Build the Next Generation Drug Discovery Platform
  The traditional view of the genome has largely centered on protein-coding and non-coding regions, as these parts show clear observable functions. The non-coding sequences previously considered junk DNA have been extensively studied for the last few decades and…
  preprints 2025 置信度 0.74
• ybyra: Y-chromosome haplogroup calling using a tree-based scoring method
  Summary We present ybyra , a Snakemake workflow for automated Y-chromosome haplogroup assignment using a tree-based scoring method with robust and transparent heuristics. The pipeline supports both human reference genome builds 37 and 38, makes use of three di…
  preprints 2025 置信度 0.74
• Evolutionary chemical learning in dimerization networks
  We present a novel framework for chemical learning based on Com- petitive Dimerization Networks (CDNs)— systems in which multiple molecular species, e.g. proteins or DNA/RNA oligomers, reversibly bind to form dimers. We show that these networks can be trained …
  preprints 2025 置信度 0.74
• Validation of DNA Quantum Entanglement Protocols
  Quantum effects in biological systems have long been debated, and DNA represents a particularly intriguing candidate for quantum information processing. Here, we report the first experimental validation of DNA quantum entanglement protocols achieving unprecede…
  preprints 2025 置信度 0.74
• Light-up nanostructures with allosteric DNA mimics of GFP
  In this study, we present a systematic approach for the rational design of synthetic allosteric DNA aptamers. This methodology enables precise control over the allosteric ON-OFF transition in fluorescent DNA aptamers, allowing for the engineering of aptamers w…
  preprints 2025 置信度 0.74
• Cross-disease genetic and epigenetic architecture of the <i>MOBP</i> locus shows convergence in ALS-PSP
  Background Myelin associated oligodendrocyte basic protein ( MOBP ) is an abundantly expressed oligodendrocyte gene. Genetic variation at the MOBP locus has been associated with risk for multiple neurodegenerative disorders, including progressive supranuclear …
  preprints 2026 置信度 0.74
• An Lsr2-like xenogeneic silencer confers immunity against AT-rich bacteriophage infection
  Abstract Lsr2-like xenogeneic silencers are widespread nucleoid-associated proteins in Actinomycetota and are encoded by diverse bacteriophages. However, their roles during bacteriophage infection, one of the most direct encounters with foreign DNA, remain une…
  preprints 2026 置信度 0.74
• From Chaos to Efficient Computing: Universal Compression, the P vs NP Divide, and the Hidden Hand of Code
  This paper explores the hypothesis that our universe functions as a highly efficient “reality engine,” guided by a fundamental principle of universal computational efficiency. Central to this framework is the P vs NP divide, which acts as a boundary constraini…
  preprints 2025 置信度 0.74
• Cross-ancestry evaluation of idiopathic pulmonary fibrosis genetic risk variants
  Genome-wide association studies of idiopathic pulmonary fibrosis (IPF) have identified 35 common genetic risk loci associated with IPF susceptibility. In this study, we evaluated the effects of the reported variants in clinically curated non-European individua…
  preprints 2026 置信度 0.74
• Bridging Quantum Mechanics and Biology at the Million-Atom Scale
  Abstract Quantum-mechanical simulations provide the most fundamental description of matter, yet their computational cost has limited applications to systems containing at most thousands of atoms. Here, we present an all-electron quantum-mechanical framework th…
  preprints 2025 置信度 0.74
• Protein structure prediction and design for high-throughput computing
  Recent advances in structural biology and machines learning have resulted in a revolution in molecular biology. This revolution is driven by protein structure prediction and design tools such as Alphafold3, Chai-1, and Boltz-2 which are now able to accurately …
  preprints 2025 置信度 0.74
• The Logical Implications of the Base-Four Number System
  In this article, the logical concepts that underpin the translation of logic circuits will be defined and presented. The intention is to apply these concepts directly to hardware and to the management of language codes in computer systems. The Quaternary Syste…
  preprints 2025 置信度 0.74
• Genomic Entropy confers an aggressive Phenotype in Mesothelioma
  Abstract Exposure to asbestos is the primary cause of mesothelioma, however the processes underpinning its initiation and evolutionary trajectory remain elusive. To address this knowledge gap, we conducted whole exome sequencing and phylogenetic analysis of 27…
  preprints 2026 置信度 0.74
• Rastair: an integrated variant and methylation caller
  ABSTRACT Cytosine methylation is a crucial epigenetic mark that impact tissue-specific chromatin conformation and gene expression. For many years, bisulfite sequencing (BS-seq), which converts all non-methylated cytosine (C) to thymine (T), remained the only a…
  preprints 2026 置信度 0.74
• Evolutionary persistence of a highly prevalent multicopy mitochondrial-derived nuclear insertion (Mega-NUMT) in Neotropical <i>Drosophila</i> flies
  Although strict maternal transmission of mitochondria is a general feature of animals for ensuring homogeneity in mitochondrial DNA (mtDNA) across generations, exceptions were reported in the recent past. For example, some extremely rare but spectacular cases …
  preprints 2026 置信度 0.74
• A Nature-Inspired Ion Trap for Parallel Manipulation of Ions on a Massive Scale
  Parallelization has revolutionized computing and DNA sequencing but remains largely unexploited in mass spectrometry (MS), which typically analyzes ions sequentially. We introduce a nature-inspired ion trap (MultiQ-IT) that enables massively parallel MS. The d…
  preprints 2025 置信度 0.74
• A novel analysis pipeline and experimental design for measuring expanded repeat instability
  The expansion of short tandem repeats is a feature of over 60 different human diseases. Ongoing somatic instability throughout a patient’s lifetime can influence disease progression and has emerged as a therapeutic target. Understanding its mechanism is essent…
  preprints 2026 置信度 0.74
• Tracing the Neanderthal–Modern Human hybrid zone using paleogenomic data
  Interbreeding between closely related lineages is a pervasive evolutionary feature across taxa 1 , including modern humans, who admixed with Neanderthals and other archaic hominins 2,3 . Identifying where gene flow between these lineages happened can shed ligh…
  preprints 2026 置信度 0.74
• NanoLoop: A deep learning framework leveraging Nanopore sequencing for chromatin loop prediction
  Chromatin loops play a crucial role in gene regulation and cellular function, providing key insights into understanding the three-dimensional structure of the genome and its impact on cellular homeostasis. Nanopore sequencing technology, with its advantages in…
  preprints 2025 置信度 0.74
• Species-specific responses to paleoclimatic changes and landscape barriers drive contrasting phylogeography of co-distributed lemur species in northeastern Madagascar
  Madagascar is a megadiverse island with exceptionally high levels of endemism, which resulted mainly from allopatric speciation promoted by the island’s complex physical geography and paleoclimatic cycles. Northeastern Madagascar is uniquely suited to test the…
  preprints 2025 置信度 0.74
• Chromosome-scale genome assembly of diploid halophyte Thinopyrum bessarabicum excludes J genome from polyploid ancestry
  Abstract Wild relatives of wheat harbour genetic diversity essential for improving resilience to climate-driven stresses, yet their deployment is hampered by unresolved evolutionary relationships and the absence of reference genomes. Here we present a chromoso…
  preprints 2026 置信度 0.74
• A Cooperative Mechanism of Eukaryotic Transcription Factor Target Search
  ABSTRACT Rapid gene activation requires transcription factors (TFs) to locate their target motifs within vast genomes. In bacteria, TF target search is accelerated by combining 3D diffusion with 1D sliding, called facilitated diffusion, yet whether eukaryotic …
  preprints 2026 置信度 0.74
• Estimating haplotype values and mutation effects in the context of a local DNA tree
  Background Single nucleotide polymorphism (SNP) arrays provide genome-wide coverage of polymorphic sites across populations, but most quantitative genetics models assume that the effects of these mutations remain constant across generations and populations. Th…
  preprints 2025 置信度 0.74
• A genome language model for mapping DNA replication origins
  Origin firing is a central process during DNA replication, but specific sequences defining replication origin usage have not been defined in human cells. Here, we show that a genome language model can accurately predict which sequences can act as an origin of …
  preprints 2026 置信度 0.74
• A computational framework for designing micron-scale crisscross DNA megastructures
  Crisscross polymerization enables the assembly of hundreds of unique DNA origami ‘slats’ into micron-sized structures with nanoscale precision. To design these megastructures, thousands of handle sequences from a fixed library must be assigned to individual sl…
  preprints 2026 置信度 0.74
• Curated high-quality genomes of 39 diverse halophilic archaea
  Archaea are widespread and ecologically important microorganisms, yet our understanding of their physiology and evolution is constrained by the limited number of complete genome assemblies available. Haloarchaea have emerged as model organisms for archaeal cel…
  preprints 2025 置信度 0.74
• A Modular Framework for Automated Segmentation and Analysis of AFM Imaging of Chromatin Organization
  ABSTRACT Chromatin organization underlies essential genome functions, but its nanoscale organization remains challenging to capture and quantify with precision. Atomic force microscopy (AFM) offers direct structural readouts of DNA and chromatin, yet translati…
  preprints 2026 置信度 0.74
• Single-cell sequencing reveals unexpected genetic diversity among <i>Bodo</i> spp. flagellates and their bacterial endosymbionts
  Bodo is a cosmopolitan genus of free living bacterivorous single-celled flagellates in the class Kinetoplastea. Members of genus Bodo are considered the closest free-living relatives to the parasitic lineages Trypanosoma and Leishmania , the causative agents o…
  preprints 2025 置信度 0.74
• A dual role for CTCF in development
  Summary CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates prope…
  preprints 2026 置信度 0.74
• Fluorinated RNA origami enables serum-stable nanodevices for sensing and targeting
  Chemically modified RNAs with increased stability and reduced immunogenicity have transformed RNA therapeutics. Rational RNA design methods, including RNA origami, seek to further extend RNA medicine and biotechnology by encoding advanced functions such as sig…
  preprints 2026 置信度 0.74
• Predicting Saturation Concentrations of Phase-Separating Proteins via Thermodynamic Integration
  Phase separation of proteins and nucleic acids into biomolecular condensates contributes to the regulation of cellular compartmentalisation in membrane-less environments. A key parameter controlling the onset of biomolecular condensate formation via liquid—liq…
  preprints 2025 置信度 0.74
• Accuracy of occurrence and abundance estimates from insect metabarcoding
  1. DNA metabarcoding—high-throughput sequencing of barcode regions from bulk samples—has become a key tool for insect biodiversity assessment. Yet, how methodological choices affect the accuracy of metabarcoding data remains insufficiently explored. In this pa…
  preprints 2026 置信度 0.74
• Capsid structures of Atlas viruses reveal an engineerable nanoparticle scaffold
  Endogenous viruses and retroelements occupy a large fraction of genomes, but the properties of proteins they encode remain largely uncharted. Here, we define Atlas viruses, a new clade of endogenous viruses in nematodes with a retrovirus-like genome organizati…
  preprints 2026 置信度 0.74
• Programmable Edge-to-Edge Assembly of RNA Nanostructures
  Constructing complex three-dimensional RNA nanostructures requires precise molecular connectors for controlled self-assembly. Existing RNA–RNA connectors, such as kissing loops, are restricted to coaxial, end-to-end joining, limiting the range of accessible ge…
  preprints 2026 置信度 0.74
• A novel NLR immune receptor from Aegilops tauschii confers resistance to wheat eyespot disease
  Abstract Eyespot, a stem-base soil-borne fungal disease, is an important constraint on wheat production in temperate regions. Resistance in wheat remains limited, with Pch1 and Pch2 being currently deployed in breeding but no underlying or associated gene iden…
  preprints 2026 置信度 0.74
• Condensate-Driven Transcriptional Reprogramming Defines Core Vulnerabilities in Esophageal and Gastric Cancers
  Biomolecular condensates organize key nuclear functions by compartmentalizing biomolecules, yet their contribution to gastrointestinal tumorigenesis remains poorly defined. Integrating multi-omics profiling, functional genomics, and molecular dynamics simulati…
  preprints 2026 置信度 0.74
• Spatial Variability in Mitochondrial Markers in m.3243A&gt;G-related Myopathy: Translational Implications for Longitudinal Studies
  Abstract Myopathy is a prevalent and disabling feature of mitochondrial disease, in which skeletal muscle accumulates fibres with mitochondrial dysfunction in a variable mosaic pattern. This intra-individual spatial heterogeneity, a key consideration in longit…
  preprints 2025 置信度 0.74
• Intrinsically disordered N-terminal and structured DNA-binding domains jointly regulate progesterone receptor transcriptional condensates
  Abstract Transcriptional condensates (TCs) are dynamic, membrane-less assemblies of proteins and nucleic acids that form at specific genomic loci to control gene expression. The primary drivers of TC formation and function are long stretches of polypeptide cha…
  preprints 2026 置信度 0.74
• Single-molecule sequencing maps replication dynamics across the fission yeast genome, including centromeres
  ABSTRACT DNA replication dynamics in fission yeast remain incompletely understood, particularly in repetitive regions such as the centromeres and the rDNA. Here, we establish DNAscent—a nanopore sequencing method that detects BrdU-labelled nascent DNA and infe…
  preprints 2025 置信度 0.74
• High resolution interaction surface mapping by PRISMA reveals novel ARID1A interactions
  Abstract Background The cBAF SWI/SNF chromatin remodelling complex controls cell proliferation and fate determination by regulating chromatin accessibility and programs of gene expression, DNA damage response, replication, splicing, translation, and cell plast…
  preprints 2026 置信度 0.74
• Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation.
  Centromere identity is specified by CENP-A, a histone H3 variant that epigenetically defines centromere position. How CENP-A is maintained at one location in rapidly evolving centromeric DNA is unknown. Using single-cell-derived clones of human cell lines, we …
  europepmc 2026 置信度 0.80
• Evaluation of a new set of Geant4-DNA Physics models for the simulation of electron track structures in liquid water up to 10 MeV.
  Background Improved Physics models for the elastic and inelastic interactions of electrons in liquid water have recently been developed and implemented in the Geant4-DNA toolkit, allowing detailed electron transport simulations up to MeV energies. Purpose To p…
  europepmc 2026 置信度 0.80
• The Dukedom of Humanesque, Volume II: The Acts of the Day and the PEDLER Corpus
  Volume II of the Humanesque constitutional narrative: twenty-two plates and a cover, recording the constitutional acts of 13-14 August 2026 together with the PEDLER corpus they govern, and closing with the open invitation that the order exists to issue. Part I…
  datacite Choudhary, Abhishek 2026 置信度 0.66 PEDLERinclinationexecutable intentNatural JusticeQEDLER
• BBP and the Informational Mirror: A Recursive Harmonic Interpretation of Modular Access
  BBP and the Informational Mirror: A Recursive Harmonic Interpretation of Modular Access Driven By Dean a, Kulik August,2025 Introduction The Bailey–Borwein–Plouffe (BBP) formula for π is renowned as a “spigot” algorithm that can directly compute the $n$th digi…
  datacite kulik, dean 2025 置信度 0.66
• The Law of Conservation of Information. HamzahXcell as the Fundamental Informational Unit of Fractal Space–Time. The Vacuum Is Not Empty: It Represents the Most Dilute Distribution of HamzahXcells. Whilst the Centre of a Black Hole Core Corresponds to the Most Densely Concentrated State of HamzahXcells. (3).
  این گزارش فنی، پروتکلِ ۹ مرحله‌ایِ «حمزه‌گسل» (HamzahXcell) را جهتِ اجرایِ الگوریتمِ عددیِ مهارِ فاجعه‌یِ خلاء کوانتومی تدوین می‌کند. ما در اینجا با تکیه بر «دکترینِ حمزه»، اثبات می‌کنیم که نوساناتِ نقطه صفر، «نویزِ جیترِ کلاک» (Clock Jitter) در سیستمِ ۱۱۵۵-بع…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• The Reality Engine: Cellular Vaults as Biological Microprocessors That Generate the Mind
  This paper summarizes the theoretical framework developed across our prior works, presenting a unified cybernetic and quantum-geometric model for eukaryotic biology grounded in the Free Energy Principle (FEP). We identify the cellular vault—a 13-megadalton rib…
  datacite Mitchell, D. B. 2026 置信度 0.66 Cellular VaultvRNA GeomeFree Energy Principle (FEP)Continuous-Variable Quantum Computing (CVQC)Amplituhedron
• Postmodern Physics of Hamzah Information.(162)
  تحلیل بنیادین، بازنویسی تانسوری و اثبات جامعِ «پارادوکس گذار فاز مایع-مایع در آب معمولی» (Liquid-Liquid Phase Transition / HDL-LDL Coexistence)، بررسی نارسایی ترمودینامیک آماری کلاسیک در توجیه هم‌زیستی دو ساختار متراکم (HDL) و کم‌تراکم (LDL) در یک دما و فشار ث…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• A Rigorous Theoretical Study of Electron Attachment in DNA: A Molecular Orbital Approach to Charge Transfer, Stability, and Radiation-Induced Effects
  This research paper by Mirza Adnan Mohtashim and Aaryan K. Rathod presents a comprehensive theoretical study of how low-energy electrons attach to DNA and cause radiation-induced damage, using molecular orbital theory and advanced quantum chemical methods. The…
  datacite Mirza Adnan Mohtashim 2026 置信度 0.66 Quantum Chemistrychemical physicsBiophysicsBiology Radition
• Python for Bioinformatics
  Python for Bioinformatics is a comprehensive guide to using Python for the analysis, interpretation, and management of biological data. Designed for readers progressing from beginner to advanced levels, the book connects programming concepts with real-world pr…
  datacite Venu, Paritala 2026 置信度 0.66 Python programming for bioinformaticsBioinformatics for beginnersComputational biology with PythonGenomics data analysis using PythonBiopython sequence analysis
• Multiple Image Encryption Using Chaotic Map And DNA Computing
  Security of image and video data has become increasingly important for various applications such as internet-based communications, video conferencing, medical and military application etc. Encryption is usually recommended to solve this issue. Repeatedly, Encr…
  datacite Aarti, Patel, Parikh, Dr. Mehul 2018 置信度 0.66 Image EncryptionAlgorithmChaotic MapDNA Computing.
• N-K AI: THE COMPLETE DETERMINISTIC INTELLIGENCE
  N-K AI: THE COMPLETE DETERMINISTIC INTELLIGENCE Zenodo Publication Description --- METADATA Attribute ValueTitle N-K AI: The Complete Deterministic Intelligence — Vertex-Based Phase-Matching ArchitectureAuthor Malik Muhammad UsmanORCID 0009-0004-3269-2918Affil…
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• The 〔HA〕Universal Operator :〔The Universal Honeycomb Aether Theory: 10.5281/zenodo. 19273496〕〕
  〔The Universal Honeycomb Aether Theory〕 〔reference〕(IMPORTANT FACT 10peV) Article Published: 28 January 2026 Constraints on axion dark matter by distributed intercity quantum sensors Yuanhong Wang, Ying Huang, …Jiangfeng Du Show authors Nature 650, pages314–31…
  datacite FairyMonk 2026 置信度 0.66 Theory of EveythingFairy MonkAxion137
• The 7 nm Universal Architecture: Lattice‑Lock Law and Its Manifestations in Biology, Computing, and Medicine
  We formulate the Lattice‑Lock Law: matter stability and structural integrity arise from resonant nodes of a torsional vacuum manifold with fundamental period λ₀ = 7.0 nm. Data convergence across nanoscale computing pathways, DNA histones, cell membranes, physi…
  datacite COOPER, JUSTIN 2026 置信度 0.66
• Data from: Discovery of genetically distinct, sympatric coral lineages with temporal but not gametic reproductive isolation
  Coral species abundance and biodiversity estimates are typically based on colony macromorphology. However, such measurements often underestimate the true diversity within coral communities because morphology does not necessarily reflect behavioral or genetic d…
  datacite Chamberland, Valérie, Gómez-Corrales, Matias, Marhaver, Kristen, Bongaerts, Pim 等 2026 置信度 0.66 FOS: Natural sciencesCoral spawning monitoringDiploria labyrinthiformisseasonal allochronySympatric speciation
• Publication: Records Broken by N-K Universal Computer with 10³⁰⁰ Entangled N-Pairs   Complete Inventory of Computational, Scientific, and Theoretical Records Shattered By Malik Muhammad Usman Multan, Pakistan.
  Publication: Records Broken by N-K Universal Computer with 10³⁰⁰ Entangled N-Pairs Complete Inventory of Computational, Scientific, and Theoretical Records Shattered By Malik Muhammad Usman Multan, Pakistan. --- Publication Metadata Field Value Title Complete …
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• CRUMB Audio Codec + Biscuit Voice Packets + Visible IPFS DAG: GPU-free intelligible speech compression with content-addressed fractal storage
  Technical disclosure of four coordinated inventions for GPU-free intelligible speech compression with content-addressed fractal storage, developed in a single working session on 28 April 2026. 1. CRUMB Audio Codec (v1-v4) Mel-spectrogram + sparse spectral peak…
  datacite Chipchase, Daniel 2026 置信度 0.66 audio codecspeech compressionmel spectrogramIPFSIPLD
• Deep-Noncode : A Deep Learning Framework to Predict the Regulatory Effects of Noncoding Genetic Variants in Cancer
  This project, titled “Deep-Noncode: A Deep Learning Framework to Predict the Regulatory Effects of Noncoding Genetic Variants in Cancer,” focuses on solving a very real problem in modern biology and medicine how to quickly and accurately understand genetic mut…
  datacite N, Yohith 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(158)
  تحلیل بنیادین، بازنویسی تانسوری و اثبات جامعِ «وضعیت شیشه‌های اسپینی سه بعدی در دمای پایین و پارادوکس‌های آشوب دما و زمان بی‌نهایت» (3D Spin Glasses & Temperature Chaos / Infinite Equilibrium Time Paradox)، بررسی تقابل میان نظریه شکست تقارن کپی‌ها (RSB) و مدل …
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• "Theory of Eveything Completed" The Universal Honeycomb Aether Theory: The Unified Field Equation(Ref.10.5281/zenodo.19446164)
  [ Fundamental Theorem ] : "The Universal Honeycomb Aether framework establishes a direct deterministic identity with the Saad-Shenker-Stanford (SSS) matrix equation." ーーーーーーーーーーーーーーーーーーーーー "Fundamental Axiom of the UHA Framework: The 114-layer bipartite Honeyc…
  datacite Fairy Monk (Independent Researcher) A=A' 2026 置信度 0.66 Theory of EveythingAxion
• N-K DNA V12 — COMPLETE ENCODING OF ALL N-K SCIENCES
  N-K DNA V12 — COMPLETE ENCODING OF ALL N-K SCIENCES 2,001 Chromosomes · 6.4 Billion Base Pairs · All Sciences Unified · Entire Quran · 99 Divine Names · Self-Learning AI SADAQA JARIYAH — FREE FOR ALL HUMANITY To read and understand and do research. Selling it,…
  datacite Usman Malik, Muhammad 2026 置信度 0.66
• Data from: Design and application of a genome-wide SNP array to improve conservation outcomes in the critically endangered Southern Corroboree Frog
  Species-specific genomic information has the potential to transform modern conservation management strategies through improved genomic impact assessment and management outcomes. Gaining genomic insights into genetic diversity, adaptability, and potential resil…
  datacite Davidson, Mikaeylah 2026 置信度 0.66 SNP chipPseudophryne corroboreechytridiomycosisGenomic Diversitycaptive breeding
• It from Motive : Proof of CPT Symmetry via UHA Equation : Dirac sea : Universal Honeycomb Aether Theory
  `The UHA Equation: Non-Perturbative Spectral Resolution to the Riemann Hypothesis via Complex Non-Resonant Fixed Points This exposition establishes the deterministic constraint forcing the non-trivial zeros of the Riemann zeta function ζ(s) onto the critical l…
  datacite Fairy Monk (Independent Researcher) A=A' 2026 置信度 0.66
• Privacy-preserving genomic testing in the clinic: a model using HIV treatment
  PURPOSE The implementation of genomic-based medicine is hindered by unresolved questions regarding data privacy and delivery of interpreted results to health-care practitioners. We used DNA-based prediction of HIV-related outcomes as a model to explore critica…
  datacite McLaren, Paul J, Raisaro, Jean Louis, Aouri, Manel, Rotger, Margalida 等 2016 置信度 0.66
• Postmodern Physics of Hamzah Information.(126)
  تحلیل فوق‌تخصصی، تمام‌ریاضیاتی و مقایسه‌ای سیاه‌چاله‌ها: نسبیت عام اینشتین در برابر مدل اطلاعاتی HamzahXcell (HIP-1155) بررسی دقیق ساختار، فرمول‌بندی، برهان خلف، نمونه‌های عددی و تطابق با داده‌های رصدی زمان واقعی حسگرهای پیشرفته کیهانی (مانند تلسکوپ افق رویداد…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• RNA reporter based CRISPR/Cas12a biosensing platform for sensitive detection of circulating tumor DNA
  CRISPR/Cas biotechnology provides an exceptional platform for biosensor development. To date, the reported CRISPR/Cas biosensing systems have shown extraordinary performance for nucleic acids, small molecules, small proteins and microorganism detection. The CR…
  datacite Deng, Fei, Goldys, Ewa, Li, Yi, SANG, Rui 等 2023 置信度 0.66 4605 Data Management and Data Science3401 Analytical Chemistry46 Information and Computing Sciences34 Chemical SciencesBiotechnology
• Unified Resonance Field Geography Theory, or Prime Field Theory-as Proposed In Quantum Bridges May, 2025
  Plain talk here. I am not easily dissuaded or intimidated, and I will not tolerate republication without recognition. I am sharing the bellow because I will either be accepted or I and those using my system will simply force acceptance. The Math is settled, th…
  datacite Edgin, Timothy 2026 置信度 0.66
• Fun-sized library prep: Miniaturization is a valid method for per-sample cost reduction in for targeted sequencing of antique and fresh and angiosperm DNA
  Premise: Genomic analysis of population structure is important to the conservation of plant species of concern. A limitation of using genetic information in conservation is the cost of obtaining large datasets. Targeted sequencing and low-volume robotic liquid…
  datacite Bullock, Madison, Fokar, Mohamed, Creek, Rylee, Stevens, Eliot 等 2026 置信度 0.66 FOS: Biological sciencesantique DNAAngiosperms353herbarialibrary miniaturization
• Data from: Inferences from epigenetic information in an ecological context: A case study of DNA methylation and early-life environmental effects on zebra finches
  DNA methylation (DNAm) is known to affect gene expression and has been suggested as a putative mechanism through which environmental factors can continuously shape phenotypic variation. DNAm data can be assessed using a variety of approaches, ranging from sing…
  datacite Tangili, Marianthi, Palsbøll, Per, Verhulst, Simon 2026 置信度 0.66 FOS: Biological sciencesDNA methylationBrood sizeearly-life stressepigenetic data
• Data and code from: Association with dynamic habitats disrupts speciation and reduces the efficacy of purifying selection in flightless beetles
  Association with temporally dynamic habitats has been proposed as a strong predictor of effective population size (Ne) and speciation rates, and thus also potentially of molecular evolution rates, but empirical insights remain limited. We use a genomic dataset…
  datacite Meramveliotakis, Emmanouil, Ntatsopoulos, Konstantinos, Vogler, Alfried P., Papadopoulou, Anna 2026 置信度 0.66 FOS: Biological sciencessubstitution ratedN/dS ratioEffective population sizeGenomics
• A PLAYER’S SOURCE CODE FROM TUTORIAL TO THE MAIN GAME WALKTHROUGHInformational Flow of Quantized Packets of Logic in an Idle Multiplayer Procedural-Generation Omniverse Grid with AI and the Lean Kernel as Proof Assistants, The Blueprint for the Construction of the Loom of Knowledge
  This preprint presents The Loom of Knowledge , a cooperative, open-hand game system and executable-reasoning architecture in which definitions, assumptions, lemmas, theorems, tactics, scientific transformations, constraints, evidence objects, and certified sta…
  datacite Georgios Lamprou 2026 置信度 0.66 Artificial intelligence not elsewhere classifiedImage processingNumerical and computational mathematics not elsewhere classifiedHuman-computer interactionDistributed computing and systems software not elsewhere classified
• P75 Cryptographic Revolution™: THE ADAM CODE™: GENESIS OF THE GHOST THE VISIONARY ORIGIN STORY: THE 2005–2017 SILICON COVENANT AND THE SINGULARITY SIGNAL
  THE ADAM CODE™: GENESIS OF THE GHOST — PAPER LXXV, THE VISIONARY ORIGIN STORY: THE 2005–2017 SILICON COVENANT AND THE SINGULARITY SIGNAL Paper P75 is the declassification of the Origin Narrative — the philosophical, strategic, and personal Genesis of the Schrö…
  datacite Schroeder, Steven Alexander 2026 置信度 0.66 ADAM CODE HDAA SMM Ring -2 Asilomar AI Principles Implementation Gap FLI signatory Kurzweil Singularity substrate sovereignty Layer 0-1 NASM x86 assembly 0xCF9 Reset Vector AGI to ASI transition defensive publication 35 USC 102 prior art 18 USC 1836 trade secret Schröder Precedence
• Postmodern Physics of Hamzah Information.(81)
  تحلیل قطعی شکست مدل ۴ نیرویی فیزیک کلاسیک و اثبات استقرار کامل منیفولد ۱۱۵۵ نیرویی حمزه (HamzahXcell) در تمامی شاخه‌های علم (ریاضیات، فیزیک، شیمی، بیولوژی، پزشکی، ژنتیک، علوم کامپیوتر، هوش مصنوعی و اقتصاد). مرحله ۱: مقدمه و پارادوکس بنیادین (ریشه تمامی تناقضات…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• Kraken2 Metagenomic Virus Database
  The Database: Kraken2 [1] database built from a classification tree containing over 700k metagenomic viruses from JGI IMG/VR [2]. (1) Wood, D. E., Lu, J., and Langmead, B. (2019). Improved metagenomic analysis with Kraken 2. Genome Biol., 20(1), 1–13. doi: 1…
  datacite Garcia, Benjamin, Simha, Ramanuja, Garvin, Michael, Furches, Anna 等 2020 置信度 0.66 59 BASIC BIOLOGICAL SCIENCES60 APPLIED LIFE SCIENCESvirusmetagenomicautism
• It from Motive
  The Geometric Dual Emergence of the 114-Layer Lattice To clarify the structural foundation of the UHA framework, the 114-layer lattice (\(N=114\)) is a geometric invariant constrained by two dual pathways: Macro-Top-Down: \(\frac{248 - 20}{2} = 114\), utilizin…
  datacite Fairy Monk (Independent Researcher) A=A' 2026 置信度 0.66
• The Constructive Model Theory of Geometric DNA
  "TCDNA: Geometric Homeostasis Theory & PsiUEngineRL Full Reproducibility Compendium: Engine + Datasets + Benchmarks + Paper*`install.packages("PsiUEngineRL")` ← CRAN Core CRAN Core Concept: install.packages("PsiUEngineRL")⚠️ Crucial Note on Versions: The CRAN …
  datacite Lombardi, Roberto 2026 置信度 0.66 Constructive Model TheoryModel TheoryMathematical logicLogicData Science
• E8 Phase-Locked Torsional Epigenetic Resonance — E8 Intelligence Research
  Using the 240 root vectors as resonant nodes, we discover that a coherent 132 Hz φ‑carrier can be amplified by a non‑abelian torsion field that twists the E8 lattice into a dynamic "torus‑grid". This grid creates a self‑sustaining phase‑locking cascade that sy…
  datacite Caldin, Andrew Stewart 2026 置信度 0.66 E8 geometryartificial intelligencequantum computingE8 latticeindependent research
• Metal-Mediated DNA Memory on Carbon Nanotube Electrodes and hBN Substrates: A Conceptual Architecture for Molecular Information Storage
  Abstract This technical note investigates a conceptual molecular memory architecture combining metal-mediated DNA duplexes, metallic carbon nanotube electrodes, DNA-origami positioning, and hexagonal boron nitride (hBN) substrates. The proposed architecture ai…
  datacite Lozac'h, Jean-yves 2026 置信度 0.66 DNA Memory Metal-Mediated DNA Carbon Nanotubes CNT Electronics DNA Origami Hexagonal Boron Nitride hBN Molecular Electronics Single-Molecule Devices Nanoelectronics Spintronics Emerging Memory Neuromorphic Hardware In-Memory Computing Nanotechnology Molecular Computing Transition Metals Conceptual Architecture
• Data Encryption Strategy with Privacy-Preserving for Big Data in Mobile Cloud using H2Hadoop
  Cloud Computing leverages Hadoop framework for process Big Data in parallel. Hadoop has bound limitations that could be exploited to execute the duty efficiently. These limitations square measure principally thanks to data section within the cluster jobs and t…
  datacite Ramathulasi, T., Reddy, C. Samba Shiva, Kumar, K. Ashok 2018 置信度 0.66 Big DataCloud ComputingHadoopH2HadoopHadoop Performance
• Enhancing Network Security and Throughput via Integrated Firewall Filtering, Token Substitution, and Dynamic XOR Ciphering
  The exponential growth of cloud computing, edge networks, and enterprise data transfers has magnified the demand for robust information security and high-efficiency network transmission. Existing network defense frameworks predominantly deploy perimeter firewa…
  datacite Kaur, Lovepreet, Suman, Er. 2026 置信度 0.66 Cloud Network Security; Firewall Filtering; Token Replacement Compression; Dynamic XOR Encryption; Network Throughput Optimization; Cyber-Attack Resilience
• Integrated RPA-CRISPR/Cas12a system towards Point-of-Care H. pylori detection
  The rapidly advanced CRISPR/Cas biosensing technology provides unprecedent potential for the development of novel biosensing systems. It provides a new approach for realizing rapid, sensitivity and highly specific pathogen nucleic acid detection, with the capa…
  datacite Li, Yi, Deng, Fei, Goldys, Ewa, Zhang, Chengchen 2023 置信度 0.66 4605 Data Management and Data Science46 Information and Computing Sciences31 Biological SciencesInfectious DiseasesBiotechnology
• Development of optimized DNA nanostructure designs towards biological applications
  Depuis leur découverte, les caractéristiques structurelles de l'ADN, incluant ses propriétés de reconnaissance moléculaire, sa synthèse programmable et son assemblage coopératif en double hélice ont grandement inspiré les sciences modernes. Parmi ces disciplin…
  datacite Bujold, Katherine 2017 置信度 0.66 Chemistry
• DNA as the Direct Cosmic OS Kernel and the Complete Presaging of Topological Antennas within the 114-Layer Bipartite Matrix
  Resonance Between Humanity and the Honeycomb Aether: DNA as the Direct Cosmic OS Kernel and the Complete Presaging of Topological Antennas within the 114-Layer Bipartite Matrix Abstract This paper expands upon the mathematical framework of the 114-layer Bipart…
  datacite Fairy Monk (Independent Researcher) A=A' 2026 置信度 0.66
• Molecular mechanics method development and applications to nucleic acid binders
  Developing new drug is a long and costly process: it takes on average more than ten years and costs over $2 billion to bring a drug to market. Drug development is a multi-disciplinary initiative involving not only chemistry and biology, but also pharmacology, …
  datacite Liu, Zhaomin 2018 置信度 0.66 Chemistry
• Interfacing DNA nanotechnology with biological systems
  L’acide désoxyribonucléique (ADN) a évolué dans la nature afin de stocker et transférer l’information génétique de toute vie sur terre. La fidélité du traitement de l’information dépend de la précision de l’appariement, par interactions non-covalentes, d’un co…
  datacite Conway, Justin 2015 置信度 0.66 Chemistry
• Results and Analysis Dataset accompanying "OrthoSeq: A Design Workflow for Thermodynamically Orthogonal DNA Sequence-Pair Libraries"
  OrthoSeq Benchmark Data This archive contains the benchmark data associated with the manuscript “OrthoSeq: A Design Workflow for Thermodynamically Orthogonal DNA Sequence-Pair Libraries.” The most directly reusable files are in extracted_libraries/, which cont…
  datacite Katzmeier, Florian, Aquilina, Matthew, Shih, William 2026 置信度 0.66
• Postmodern Physics of Hamzah Information.(2).
  بر پایه تانسورهای محاسباتی فیزیک اطلاعات حمزه (HIP) و فیلترهای ناوردای مانیفلد ۱۱۵۵ بعدی، کل شاخه‌های پنج‌گانه مکانیک کلاسیک دچار خطای ساختاری و کوررنگی آکادمیک هستند. مکانیک سنتی، فضا-زمان را ظرفی پیوسته و تهی و ماده را اصیل می‌داند؛ در حالی که در HIP، هر حرک…
  datacite HAMZAH, SEYED RASOUL 2026 置信度 0.66
• strider: open nucleic-acid thermodynamics, TMSD kinetics, and sequence design
  strider is a Python library for the thermodynamics and kinetics of DNA/RNA circuits: nearest-neighbor free energies, Zuker/McCaskill secondary-structure prediction, multi-strand tube equilibria, toehold-mediated strand-displacement kinetics, reaction-network d…
  datacite Venegas, Emilio 2026 置信度 0.66 nucleic-acid thermodynamicsDNA computingtoehold-mediated strand displacementRNA secondary structuresequence design
• Economic Impact of Quantum Electrical Metrology
  Quantum Electrical Metrology (QEM) has a fundamental role within the National Measurement Infrastructure. QEM enables enhanced measurement capability by exploiting quantum strategies for improved sensitivity and accuracy of measurements, from which different i…
  datacite Pullmann, Liliya, Weymann, Lukas, Reiß, Thomas, Schmaltz, Thomas 等 2024 置信度 0.66
• Key Insights on the Socio-Economic Impact of Quantum Electrical Metrology
  Quantum Electrical Metrology (QEM) has a fundamental role within the National Measurement Infrastructure. QEM enables enhanced measurement capability by exploiting quantum strategies for improved sensitivity and accuracy of measurements, from which different i…
  datacite Pullmann, Liliya, Weymann, Lukas, Reiß, Thomas, Schmaltz, Thomas 等 2024 置信度 0.66