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Advances in artificial intelligence (AI) and synthetic biology are transforming biological research and biotechnology. These fields are for the first time enabling the design and development of human and bacterial cells that can serve as "living" drug delivery…
europepmc
2026
置信度 0.80
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Quorum sensing-based genetic circuits are gaining traction in synthetic biology as they link population-level behaviour to individual cell responses. However, tuning these circuits remains challenging due to complex dynamics, particularly during the 'Learn' ph…
europepmc
2025
置信度 0.80
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Despite the fact that microbes in natural environments spend most of their time in growth arrest, we understand little about how this physiological state affects the performance of engineered genetic circuits. Here, we measure repression curves from a library …
europepmc
2026
置信度 0.80
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This article presents a synthetic biology framework called Chemical Organization Theory (COT), that formalizes synthetic biology concepts using reaction networks. We show how this formalism applies across synthetic biology scales, from genetic circuits and met…
europepmc
2026
置信度 0.80
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The field of synthetic biology has become a revolutionary tool for engineering microorganisms capable of precise, programmed cancer treatment. Unlike conventional cancer treatments, which lack safe, selective toxicity, engineered microbial cells can detect tum…
europepmc
2026
置信度 0.80
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Arsenic contamination of drinking water remains a persistent global health burden and an environmental justice challenge, particularly for low-resource communities that lack access to reliable monitoring tools. Synthetic-biology-driven biosensors offer a promi…
europepmc
2026
置信度 0.80
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Precise timing of gene expression is a common feature in natural regulatory networks but is rarely implemented in synthetic pathways, where static control often limits performance. Here, we expand the use of bacterial extracytoplasmic function (ECF) σ factors …
europepmc
2026
置信度 0.80
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Plant-derived pigments offer sustainable alternatives to synthetic colorants, yet their practical deployment in textiles is limited by restricted chemical diversity and low abundance. Liverworts represent a source of diverse chemical compounds, and the model l…
europepmc
2026
置信度 0.80
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Despite decades of therapeutic advances, cardiovascular diseases remain the leading cause of global mortality, underscoring the need for strategies that move beyond untargeted systemic pharmacotherapy. Synthetic biology introduces a programmable therapeutic pa…
europepmc
2026
置信度 0.80
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Precise temporal control of gene expression is critical for studying plant biology and engineering complex crop traits. Current systems enable chemically inducible regulation but rely on costly or agriculturally impractical inducers and lack the flexibility ne…
europepmc
2026
置信度 0.80
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A unique balance of seemingly contradictory properties like robustness and plasticity, or evolvability and functional canalisation, characterises biological systems. To understand the basis of these properties, we investigate gene regulation, which is at the c…
europepmc
2026
置信度 0.80
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The growing bioeconomy demands sustainable platforms for the production of high-value pharmaceuticals, nutraceuticals, and industrial compounds. Plant tissue culture (PTC) is an attractive alternative as it provides a means of controlled production of secondar…
europepmc
2026
置信度 0.80
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Post-translational control enables rapid and precise regulation of cell behavior. Despite these advantages, general strategies to build phosphorylation-based synthetic circuits are limited. Here we reasoned that engineered allostery, a technique that has been …
europepmc
2025
置信度 0.80
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Inducible expression of endogenous and foreign genes has been a pivotal driving force behind a lot many seminal breakthroughs in biotechnology. Synthetic biology, a very promising field, largely relies on transgene expression platforms which facilitate conveni…
europepmc
2026
置信度 0.80
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Synthetic biology is an interdisciplinary field that integrates knowledge and techniques from modern biology and many other disciplines to design and construct novel biological systems or to modify existing life forms. Its core technologies include gene editin…
europepmc
2026
置信度 0.80
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Closed-loop gene circuits are paving the way toward self-driving medicine: therapeutics that continuously sense physiological signals, compute responses, and autonomously tune therapeutic output. Yet clinical practice still relies largely on open-loop dosing a…
europepmc
2026
置信度 0.80
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Sponge RNAs (spRNAs) play an important regulatory role in bacterial small RNA (sRNA) networks, but their engineering and quantitative systems-level properties are unexplored. Here, we design, build, and quantitatively characterise synthetic spRNA-based gene ci…
europepmc
2026
置信度 0.80
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Chemically inducible gene regulatory systems, with inducible promoters as their core regulatory elements, are central to advancing synthetic biology by enabling precise, dynamic, and orthogonal control of gene expression in response to chemical signals. Recent…
europepmc
2026
置信度 0.80
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Immunotherapy has revolutionized the treatment of cancers, infections, and autoimmune disorders by harnessing immune mechanisms such as signal recognition, intracellular cascades, and mediator release. However, clinical translation remains hindered by poor spe…
europepmc
2026
置信度 0.80
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Optoswitches are of particular interest to the metabolic engineering community, as light has a superior advantage of tunability and reversibility. However, the light-shading effect at industrial scales remains an unsolved challenge. Here, we report optogenetic…
europepmc
2026
置信度 0.80
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Cyanobacteria, as a group of prokaryotic photosynthetic microorganisms, have recently garnered widespread attention in the fields of synthetic biology and green biomanufacturing due to their ability to utilize light energy and carbon dioxide for autotrophic gr…
europepmc
2026
置信度 0.80
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Correction to: npj Systems Biology and Applications https://doi.org/10.1038/s41540-025-00621-y , published online 02 December 2025
europepmc
2026
置信度 0.80
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Background Technologies developed over the past decade have made Saccharomyces cerevisiae a promising platform for producing various natural products. Balancing multi-enzyme expression, while maintaining robust microbial growth, remains a limiting factor for e…
europepmc
2026
置信度 0.80
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Biofilms are intricately organized microbial communities enveloped in self-produced extracellular polymeric substances. They display remarkable resilience to environmental and antimicrobial stresses and adhere to various surfaces. Synthetic biology, which comb…
europepmc
2026
置信度 0.80
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Synthetic biology is reshaping in vitro diagnostics (IVD) by enabling programmable and modular biosensing elements that can be integrated into point-of-care testing (POCT) platforms. Compared with conventional assays that depend on fixed chemistries and centra…
europepmc
2026
置信度 0.80
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Engineered live biotherapeutic products (eLBPs) represent an emerging class of programmable microbial therapies capable of sensing and responding to host physiology. Advances in microbiome science and synthetic biology have driven the development of engineered…
europepmc
2026
置信度 0.80
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Oncolytic bacteria have emerged as a promising platform for targeted cancer therapy owing to their intrinsic ability to preferentially colonize tumor tissues, induce direct tumor cell killing, and remodel the tumor microenvironment to activate antitumor immuni…
europepmc
2026
置信度 0.80
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Scalable genetic circuits are essential for implementing complex functions in living cells. Toward this goal, RNA regulators can provide a much-needed parts library with added benefits of low metabolic load, design flexibility, and logic capacity. However, des…
europepmc
2026
置信度 0.80
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In the past decades, a wide suite of design tools for biological systems has been developed, but using these to create biotechnologies that achieve reliable and predictable behaviour remains challenging. Modelling approaches have enabled researchers to travers…
europepmc
2026
置信度 0.80
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Lactic acid bacteria (LAB), as one of the key microorganisms in the food industry, play a crucial role in functional food fermentation. However, current LAB strains are limited by challenges, such as plasmid instability, low gene expression efficiency, and com…
europepmc
2026
置信度 0.80
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MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression. Their dysregulation is closely associated with various diseases, positioning them as biomarkers of cellular state. Synthetic biology has leveraged these properties to engineer miR-based …
europepmc
2026
置信度 0.80
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Cell-free expression systems offer a method for the rapid prototyping of DNA circuits and functional protein synthesis. While crude extracts remain a black box with many components carrying out unknown reactions, PURE contains only the required transcription a…
europepmc
2026
置信度 0.80
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The rational design of smart bacteria represents a transformative advance in synthetic biology, enabling unprecedented spatiotemporal precision in microbial sensing and signal processing. By integrating sophisticated genetic circuits, these engineered systems …
europepmc
2026
置信度 0.80
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Synthetic biology aims to achieve predictable, programmable control over living systems by designing and engineering biological components and functions. Over the past 25 years, the field has advanced from foundational molecular tools to increasingly complex s…
europepmc
2026
置信度 0.80
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Intercellular signaling in bacteria is often mediated by small molecules secreted by cells. These small molecules disperse via diffusion, which limits the speed and spatial extent of information transfer in spatially extended systems. Theory shows that a secon…
europepmc
2026
置信度 0.80
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Bioengineered bacteria have emerged as a transformative platform in cancer immunotherapy, offering unique opportunities for selective tumour targeting, immune modulation, and localised delivery of therapeutic molecules. Their natural ability to colonise hypoxi…
europepmc
2026
置信度 0.80
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Plant synthetic biology is a highly innovative field that aims to better understand, redesign, and reprogram plants. Progress in recent years has been driven by technical developments such as modular cloning, gene circuits, genome editing, and synthetic genomi…
europepmc
2026
置信度 0.80
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Synthetic biology is transforming how we understand and teach microbial energy metabolism. In a recent study (F. Li, B. Zhang, X. Long, H. Yu, et al., Nat Commun 16:2882, 2025, https://doi.org/10.1038/s41467-025-57497-z), the authors demonstrated a synthetic g…
europepmc
2026
置信度 0.80
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The soil dwelling bacteria Streptomyces is a prolific producer of bioactive natural products (NPs). The sophisticated cellular machinery required to produce NPs is frequently regulated by quorum-sensing systems, consisting of cluster situated regulators (CSRs)…
europepmc
2026
置信度 0.80
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Regulation of gene transcription based on clustered regularly interspaced short palindromic repeats (CRISPR) is a powerful tool for constructing synthetic gene circuits in Saccharomyces cerevisiae. The current CRISPR-based regulatory approaches primarily focus…
europepmc
2026
置信度 0.80
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The Modular Cloning (MoClo) and PhytoBrick standards have revolutionized plant synthetic biology by establishing a standardized, hierarchical assembly grammar. However, as the engineering of complex metabolic pathways, multi-trait stacks, and synthetic gene ci…
europepmc
2026
置信度 0.80
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Feedforward loops (FFLs) and feedback loops (FBLs) are ubiquitous network motifs that mediate signal filtering, pulse generation, and state switching; yet, how coupling FBLs to FFLs produces robust multistability-a key mechanism for cellular decision-making-re…
europepmc
2026
置信度 0.80
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Metabolic diseases, such as obesity and diabetes, have risen due to lifestyle changes. Traditional treatments, including dietary modifications and pharmacological interventions, are limited by low compliance and adverse effects, highlighting the need for alter…
europepmc
2026
置信度 0.80
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Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with limited therapeutic options and poor clinical outcomes due to the absence of hormone-responsive receptors. The advent of synthetic biology, which integrates molecular biology with engi…
europepmc
2026
置信度 0.80
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RNA therapeutics offer transformative potential for neural repair. However, various delivery challenges continue to hinder the clinical translation of RNA therapeutics. Synthetic biology, as an interdisciplinary cutting-edge field, improves delivery systems by…
europepmc
2026
置信度 0.80
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Conjugation has emerged as an attractive tool in synthetic biology by delivering designed genetic circuits to diverse microbes simultaneously without isolation. Insights into conjugative machinery have enabled the repurposing of these systems to deliver geneti…
europepmc
2026
置信度 0.80
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Synthetic biology is reshaping cancer immunotherapy by enabling living therapeutics that sense, compute, and act within tumors. This review categorizes recent advances across three modalities: engineered CAR-T cells, oncolytic bacteria, and oncolytic viruses. …
europepmc
2026
置信度 0.80
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Artificial intelligence (AI) is advancing synthetic biology biosensors (SBBs), driving a fundamental shift from rational design to AI-driven prediction. This review establishes a systematic framework linking AI algorithms to the Design-Build-Test-Learn (DBTL) …
europepmc
2026
置信度 0.80
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Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availability and performance in alternative organisms. To expand chassis options, we developed an experimental-theore…
europepmc
2026
置信度 0.80
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Growth-mediated dilution can destabilize synthetic gene circuits by reducing intracellular concentrations of key regulatory proteins. Here, we present a protocol that uses liquid-liquid phase separation to buffer dilution of transcription factors and stabilize…
europepmc
2026
置信度 0.80
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Hypoxic conditions caused by submergence or soil waterlogging constrain plant growth and productivity. To survive, plants coordinately reprogram both sugar metabolism and phytohormone signaling to trigger adaptive responses; yet, the integrative regulatory fra…
europepmc
2026
置信度 0.80
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Methylotrophic yeasts such as Pichia pastoris are widely used for heterologous protein production because they contain strong and tightly regulated promoters. However, the use of methanol as an inducer presents several practical challenges, including toxicity,…
europepmc
2026
置信度 0.80
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T7 RNA polymerase is ubiquitously used in the fields of synthetic biology and biotechnology. Yet the ability to precisely and modularly regulate T7 RNAP remains surprisingly limited. Here, we engineer a T7 RNAP regulatory toolbox consisting of programmable syn…
europepmc
2025
置信度 0.80
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Regenerative engineering harnesses materials science and stem cell biology to develop strategies to repair damaged and diseased tissue. Despite advances in designer materials, few techniques effectively provide auto-regulated feedback mechanisms that govern ho…
europepmc
2025
置信度 0.80
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Mammalian synthetic biology holds great promise for treating complex diseases but faces challenges such as functional leakage and imprecise control dynamics. The advent of synthetic promoters (synPs) and transcription factors (synTFs) has expanded the genetic …
europepmc
2026
置信度 0.80
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europepmc
2026
置信度 0.80
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Quorum sensing (QS) is a cell-cell communication mechanism that enables bacteria to coordinate gene expression in response to population density and community composition. In many pathogens, QS plays a central role in host colonization and virulence, making it…
europepmc
2026
置信度 0.80
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The CRISPR-Cas system has evolved into a highly efficient platform for genome editing and programmable gene regulation, demonstrating broad application potential in microbiology, biotechnology, and medicine. However, traditional CRISPR tools typically rely on …
europepmc
2026
置信度 0.80
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Despite rapid improvements in our ability to engineer novel biological systems, robust biodesign of synthetic gene circuits-networks of synthetic genes regulating each other-has been limited by a lack of standardized methods for understanding and reproducibly …
europepmc
2026
置信度 0.80
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2,4-Diacetylphloroglucinol (DAPG) is a valuable antimicrobial compound with significant agricultural potential, suffers bioproduction limitations from host toxicity and inefficient downstream processing. This study engineered DAPG-hyper-tolerant Escherichia co…
europepmc
2026
置信度 0.80
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Cell-free systems have been highlighted as a transformative technology in synthetic biology, offering substantial technological advantages over traditional in vivo methods. By leveraging cellular metabolic machinery of the cells and decoupling cell growth from…
europepmc
2026
置信度 0.80
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Competitive protein dimerization networks offer an alternative to transcriptional genetic circuits by enabling fast molecular decision-making through direct protein-protein interactions. Implementing these networks currently requires challenging de novo protei…
europepmc
2026
置信度 0.80
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Cognition is often associated with complex brains, yet many forms of learning─such as habituation, sensitization, and even spacing effects─have been observed in single cells and aneural organisms. These simple cognitive abilities, despite their cost, offer evo…
europepmc
2025
置信度 0.80
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Precise intercellular communication is critical for cellular decision-making. The segmentation clock is an oscillatory gene network regulating periodic segmentation of the presomitic mesoderm (PSM) in vertebrate embryos. Oscillations between neighboring cells …
europepmc
2026
置信度 0.80
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Engineered bacteria are emerging as a transformative class of cancer therapeutics. Recent advances in synthetic biology have expanded the genetic circuit toolbox, enabling the programmable control of attenuation, payload release, and immunomodulation. These de…
europepmc
2026
置信度 0.80
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Regulating gene expression with precision is essential for cellular engineering and biosensing applications, where rapid, programmable, and sensitive control is desired. Current approaches to regulatory circuit design often rely on control at a single regulato…
europepmc
2026
置信度 0.80
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Genetic circuits are a cornerstone of synthetic biology, enabling programmable control of cellular behavior for applications in health, sustainability, and biotechnology. While Genetic Design Automation (GDA) tools have optimized and streamlined the design of …
europepmc
2026
置信度 0.80
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The stability of synthetic gene circuits is limited by cellular growth and division. Zhang et al. demonstrated how engineered condensates of transcription factors can stabilize gene expression and enhance bio-based production. This work establishes the spatial…
europepmc
2026
置信度 0.80
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Living microbial therapeutics have arisen as a novel category of medications that extend beyond traditional small molecules and biologics. Advancements in synthetic biology have facilitated the rational engineering of microorganisms to detect host or disease-r…
europepmc
2026
置信度 0.80
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Chimeric antigen receptor (CAR)-based immunotherapy has evolved from early linear receptor designs into increasingly sophisticated biological signal processing systems. While conventional CAR-T cell therapies have achieved remarkable clinical success, particul…
europepmc
2026
置信度 0.80
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Band-pass filters, which selectively transmit signals within a defined range of input magnitudes, are fundamental components of signal-processing systems. In cellular gene circuits, band-pass behavior has likewise been pursued as a mean to implement complex si…
europepmc
2026
置信度 0.80
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In recent years, synthetic biology has been widely applied to engineer and program cellular behaviors. Using this approach, bacteria can be designed to express immunotherapeutic agents, improve tumor targeting, and deliver therapeutic payloads directly to tumo…
europepmc
2026
置信度 0.80
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Abstract Inflammatory bowel diseases (IBD) are characterized by chronic intestinal inflammation, driving a need for real-time, noninvasive monitoring of inflammatory biomarkers. Here we propose a Lactobacillus-based probiotic biosensor engineered to detect mol…
europepmc
2026
置信度 0.80
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Precise and orthogonal regulation of genetic circuits is a central challenge in synthetic biology, particularly at the translational level where tools remain scarce. Here, we address this by engineering suppressor transfer RNAs (sup-tRNAs) charged with canonic…
europepmc
2026
置信度 0.80
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While progress has been made in developing synthetic regulatory circuits for a variety of applications, circuit engineering remains highly unpredictable due to the inherent complexity of the intracellular medium. With recent advances in high-throughput molecul…
europepmc
2026
置信度 0.80
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Micropeptides are emerging as a previously hidden layer of the human proteome, redefining the long-standing separation between coding and noncoding genomic regions. Once dismissed as translational noise, sORFs embedded within lncRNAs, circRNAs, pseudogenes, an…
europepmc
2026
置信度 0.80
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Optogenetic methods are powerful tools for synthetic biology, allowing light to control cellular processes. While most bacterial optogenetic systems regulate gene expression at the transcriptional level, relatively few enable post-translational control, which …
europepmc
2026
置信度 0.80
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The budding yeast Saccharomyces cerevisiae has moved beyond an evolved and domesticated single-celled microorganism into a deliberately engineered biological substrate. Advances in synthetic genomics, illustrated by the international Synthetic Yeast Genome (Sc…
europepmc
2026
置信度 0.80
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Cell-free protein synthesis (CFPS) is an in vitro platform that enables rapid protein production using cell extracts, energy sources, and genetic templates. Owing to its fast response, elimination of cell culture, open reaction environment, lyophilization comp…
europepmc
2026
置信度 0.80
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The advent of synthetic biology, enabling the construction of synthetic genetic circuitry with designed functionality, has has a revolutionary impact on medicine, agriculture, sustainable energy, and the industrial production of high-value compounds over the l…
europepmc
2026
置信度 0.80
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Gallic acid (GA) is a value-added phenolic compound widely applied in the food, pharmaceutical, and cosmetic industries. Traditionally obtained through chemical hydrolysis of tannins, its production faces limitations related to environmental impact, substrate …
europepmc
2026
置信度 0.80
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Since its inception, synthetic biology has relied on linear genetic modifications to treat living cells as biological counterparts to silicon microchips and computer-aided manufacturing. This paradigm is deeply rooted in the historical frameworks of Turing, Bo…
pubmed
El-Sharoud WM
2026 Aug 2
置信度 0.82
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Synthetic biology is expanding from single-species engineering toward the design of synthetic microbial consortia capable of distributed metabolism, coordinated behavior, and enhanced functional robustness. However, engineering frameworks derived from intracel…
pubmed
Fernández-Niño M, Wessjohann LA, Guillamón JM, Burgos-Toro D 等
2026 Jul 31
置信度 0.82
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Regenerative engineering harnesses materials science and stem cell biology to develop strategies to repair damaged and diseased tissue. Despite advances in designer materials, few techniques effectively provide auto-regulated feedback mechanisms that govern ho…
pubmed
Eidman ZM, Sharma J, Lee JC, Schulze NF 等
2026 Jul 28
置信度 0.82
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Technologies developed over the past decade have made Saccharomyces cerevisiae a promising platform for producing various natural products. Balancing multi-enzyme expression, while maintaining robust microbial growth, remains a limiting factor for engineering …
pubmed
Borah M, Gu S, Saied EM, Arenz C 等
2026 Jul 27
置信度 0.82
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Regulation of gene transcription based on clustered regularly interspaced short palindromic repeats (CRISPR) is a powerful tool for constructing synthetic gene circuits in Saccharomyces cerevisiae. The current CRISPR-based regulatory approaches primarily …
pubmed
Liang Y, Qi X, Gao S, Wang Y 等
2026 Jul 17
置信度 0.82
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Biomolecular condensates possess distinct solvent environments. This has been postulated to affect biochemical activities. Here, we report the discovery of inherent catalytic functions of condensates formed by intrinsically disordered proteins. The proteins th…
pubmed
Chen MW, Guo X, Farag M, Qian N 等
2026 Jul 24
置信度 0.82
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The soil-borne fungal pathogen Verticillium dahliae (V. dahliae) is the causal agent of Verticillium wilt (VW), a vascular disease that severely threatens global cotton production. Although cell wall lignification represents a cornerstone of plant immunity, th…
pubmed
Ba Z, Zheng J, Liu Y, Guo J 等
2026 Jul 22
置信度 0.82
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Escherichia coli (E. coli) cell factories are widely used to convert biomass-derived substrates into bulk and fine chemicals, including amino acids and organic acids. During high-level chemical production, however, product accumulation and metabolic burden can…
pubmed
Zhang L, Cheng Z, Yang J, Yang X 等
2026 Jul 24
置信度 0.82
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Biocatalysts are prized for their enantioselectivity, but slow chromatographic separations required to measure enantiomeric excess bottleneck their development. To overcome this limitation, we evolve enantioselective transcription factors (eTFs) that convert e…
pubmed
d'Oelsnitz S, Kim W, Zhao NN, Hardtke H 等
2026 Jul 23
置信度 0.82
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Gene therapies that selectively eliminate tumor cells within a heterogenous population remain an elusive goal in oncology, largely due to the difficulty to achieve cancer specificity by strict definition. Here, we engineer a therapeutic gene circuit capable of…
pubmed
Liu Q, Xiong Q, Xie G, Chen Q 等
2026 Jul 23
置信度 0.82
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Beyond their traditional role as dietary lipid emulsifiers, bile acids (BAs) function as pleiotropic signaling molecules that regulate metabolism, inflammation, and diverse disease processes. Taurine-conjugated bile acids (Tau-BAs) and the glycine-to-taurine c…
pubmed
Lu Z, Shi Y, Deng N, Zhang C
2026 Jul 22
置信度 0.82
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Post-translational control enables rapid and precise regulation of cell behavior. Despite these advantages, general strategies to build phosphorylation-based synthetic circuits are limited. Here we reasoned that engineered allostery, a technique that has been …
pubmed
Cao Q, Toettcher JE
2026 Aug
置信度 0.82
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The evolution of gene regulation is a major source of evolutionary adaptation and innovation, particularly when organisms encounter new or changing environments. Central to this process is the emergence of new transcription factor binding sites (TFBSs). Adapti…
pubmed
Westmann CA, Goldbach L, Wagner A
2026 Jul 21
置信度 0.82
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L-lysine-derived alkaloids represent a structurally diverse and pharmacologically significant class of nitrogen-containing natural products with broad utility as pharmaceutical agents and industrial platform chemicals. However, their microbial biosynthesis has…
pubmed
Lin P, Lee SY
2026 Jul 28
置信度 0.82
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Plant-derived pigments offer sustainable alternatives to synthetic colorants, yet their practical deployment in textiles is limited by restricted chemical diversity and low abundance. Liverworts represent a source of diverse chemical compounds, and the model l…
pubmed
Lormet A, Haseloff J, Romani F
2026 Jul 18
置信度 0.82
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Arsenic contamination of drinking water remains a persistent global health burden and an environmental justice challenge, particularly for low-resource communities that lack access to reliable monitoring tools. Synthetic-biology-driven biosensors offer a promi…
pubmed
Zeballos Huarachi OS, Tambo Santos AA, Aliaga Rodriguez JJ, Porcel Velasquez AK 等
2026 Jul 17
置信度 0.82
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Programmed -1 ribosomal frameshifting (-1 PRF) is a recoding mechanism utilized by viruses to expand their coding capacity and modulate the stoichiometric ratio of -1 frame and 0 frame translation products. The stability of mRNA secondary structure at the ribo…
pubmed
Chen Y, Zhao W, Chen H, Zhou H 等
2026 Jul 16
置信度 0.82
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Synthetic biology can program cellular behavior but remains underused in regenerative medicine. This commentary argues that integrating synthetic biology with tissue engineering should target vascularization and immune integration through compact, context-awar…
pubmed
Vlahos AE
2026 Jul 15
置信度 0.82
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This article presents a synthetic biology framework called Chemical Organization Theory (COT), that formalizes synthetic biology concepts using reaction networks. We show how this formalism applies across synthetic biology scales, from genetic circuits and met…
pubmed
Veloz T, Jendreiko C
2026
置信度 0.82