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• Stacked Domain Learning: A structured framework for integrating disciplinary perspectives through predictive modeling
  Large-scale studies increasingly collect data across multiple disciplines such as neuroscience, psychology, and genetics. Combining these data offers new opportunities for understanding human behavior, but it also presents substantial analytical challenges. Tr…
  preprints 2026 置信度 0.74
• HERO: A hierarchy-aware analysis pipeline for reducing and refining whole-brain atlas-mapped cellular datasets
  ABSTRACT Advances in high-throughput mesoscale microscopy and machine learning-based image analysis pipelines have made unbiased whole-brain imaging widely accessible. However, translating the resulting atlas-mapped datasets into biologically meaningful result…
  preprints 2026 置信度 0.74
• Distinguishing imagery and perception in generative models of brain function
  Perception is thought to be a generative process, relying on prior beliefs and expectations to shape what we experience. This generative architecture also enables the internal generation of sensory activity in the absence of input, in the form of imagination. …
  preprints 2026 置信度 0.74
• A Two-Fluid Model of Brain Dynamics
  We develop a theoretical proposal linking vacuum stability and brain dynamics through superconductivity-inspired coherence, symmetry reduction, and the thermodynamic stabilization of low-entropy regimes. We take an unbroken SU(3) structure as a candidate stabl…
  preprints 2026 置信度 0.74
• Contextualized phenovectors reveal a Drosophila serotonergic circuit controlling satiety
  Distinguishing whether a neural circuit genuinely controls a holistic behavioral state, rather than merely producing isolated effects, is a central challenge in neuroscience. Feeding research illustrates the problem: decades of work have reached conflicting co…
  preprints 2026 置信度 0.74
• Complementing Causal Explanation: A Future-Oriented Perspective on Scientific Inquiry
  Scientific inquiry relies on causal explanation, whereby phenomena are understood through the antecedent conditions, interactions and laws producing the current configuration of a system. We introduce a complementary approach termed Future Compatibility (FC), …
  preprints 2026 置信度 0.74
• A distributed pallial circuit links sensory and bodily representations to aversive motivational value in the goldfish dorsomedial pallium
  ABSTRACT Understanding how neural circuits transform sensory and bodily signals into motivational states and adaptive behavior is a central problem in neuroscience. In teleost fish, the dorsomedial telencephalon (Dm) is a key pallial region implicated in both …
  preprints 2026 置信度 0.74
• MacaSurfer: automated surface-volume mapping across the macaque lifespan
  Abstract Macaque MRI is central to translational, developmental, and comparative neuroscience. However, automated structural processing of macaque MRI remains challenging because image quality varies substantially across sites, standardized non-human primate i…
  preprints 2026 置信度 0.74
• Computationally mapping olfactory receptors to odor percepts using docking energy scores
  Mapping the olfactory factors directly to perceived smells has broad implications for neuroscience, chemistry, and medicine. Since the discovery of olfactory genes in 1991, the completion of the olfactory code has been hindered by two obstacles: the unknown co…
  preprints 2026 置信度 0.74
• Neural representation of hedonic valence during narrative listening
  Hedonic valence, the intrinsic pleasantness or unpleasantness of an experience, is fundamental to human psychological functioning. Yet, how valence is represented in the brain remains an open question. Functional MRI studies have demonstrated that the brain en…
  preprints 2026 置信度 0.74
• Spike Train Matching and Waveform Tracking Disagree: A Graph-Based Motor Unit Agreement Framework
  Abstract Background Motor units (MU) are the fundamental building blocks of movement, and reliably identifying the same MU across recordings is essential for neuroscience, rehabilitation, and neural interface research. Two mainstream methods for this purpose, …
  preprints 2026 置信度 0.74
• The Dual Lens Model of Behavior: A Conceptual Framework for Integrating Functional Behavior Assessment and Nervous System State
  Traditional Functional Behavior Assessments (FBAs) excel at isolating the environmentalcontingencies that maintain challenging behaviors over time. However, by focusing primarily onexternal consequences, the standard operant paradigm often overlooks the biolog…
  preprints 2026 置信度 0.74
• GESTURE: unsupervised genotype-specific behavioral phenotyping in rodents via graph-based representation learning
  The automated quantification of complex animal behavior is fundamental to neuroscience and pharmacology, yet converting high-dimensional pose data into reproducible and interpretable behavioral measures remains challenging. Here, we present GESTURE, an unsuper…
  preprints 2026 置信度 0.74
• A geometric and dynamical theory of latent computations in biological neural networks
  Many neural recordings have revealed low-dimensional sets of behaviorally relevant variables encoded within large-scale neural activity patterns. However, dimensionality reduction analyses alone cannot yield causal explanations for how networks stably implemen…
  preprints 2026 置信度 0.74
• The ANCHOR Framework for Psychedelic Accompaniment
  AbstractPsychedelic-assisted interventions are complex, context-sensitive interventions in which pharmacological, psychological, relational, environmental, cultural, and temporal processes interact. Trials of psilocybin and related compounds have reported prom…
  preprints 2026 置信度 0.74
• PiEEG Server: An Open-Source Real-Time EEG Streaming Platform for AI-Driven Brain-Computer Interfaces
  We present PiEEG Server, an open-source Python-based streaming platform that bridges low-cost PiEEG electroencephalography (EEG) hardware with modern artificial intelligence (AI) and brain-computer interface (BCI) pipelines. Running on a Raspberry Pi or any Bl…
  preprints 2026 置信度 0.74
• An updated patent review of mGlu5 negative allosteric modulators (2018 - present).
  Metabotropic glutamate receptor subtype 5 (mGlu5) is an important regulator of excitatory neurotransmission and remains a therapeutic target for neuropsychiatric and neurological disorders, including substance use disorders, depression, Fragile X syndrome, Par…
  europepmc 2026 置信度 0.80
• Erratum: Lee et al., "Single-Cell-Resolution Fate Mapping Reveals Embryonic Venous Origins of Fenestrated Hindbrain Choroid Plexus Vasculature".
  europepmc 2026 置信度 0.80
• Social isolation upregulates takeout expression in female Drosophila melanogaster to promote sucrose preference.
  Previous research suggests that social isolation induces changes in gene expression that encode a starvation-like brain state and reduce sleep. However, the extent to which social isolation alters behaviors via sex-specific brain changes is unclear. Here, we u…
  europepmc 2026 置信度 0.80
• Reversal Nanoimprinted 3D Plasmonic Sensor Around Microposts for Cell and DNA Detection.
  Localized surface plasmon resonance biosensors are promising devices for label-free detection of live cells and biomolecules. However, typical plasmonic sensors have limited surface area, planar electromagnetic fields, and poor compatibility with three-dimensi…
  europepmc 2026 置信度 0.80
• Standardized depth-resolved mapping of anterior cingulate cortex synaptic markers reveals inhibitory marker alterations following prenatal valproic acid exposure.
  Proper coordination of excitatory and inhibitory synaptic inputs is essential for stable neural circuit activity and flexible behavior. Although excitation-inhibition (E/I) imbalance has been implicated in neurodevelopmental disorders, quantitative histologica…
  europepmc 2026 置信度 0.80
• Editorial: Artificial intelligence in neurosurgical practices: current trends and future opportunities.
  Artificial intelligence (AI) has moved from a topic of academic curiosity to a structural component of neurosurgical research and, increasingly, of clinical workflows. Less than a decade after the first systematic reviews compared machine learning models again…
  europepmc 2026 置信度 0.80
• Does Stimulus-Preceding Negativity Reflect Predictions in a Somatosensory Roving Paradigm?
  The mismatch negativity (MMN) has since decades become one of the most prominent phenomena in cognitive neuroscience, recognized as a brain response indexing automatic change detection. While substantial work has characterized poststimulus mismatch responses (…
  europepmc 2026 置信度 0.80
• Aftereffects of 1-week chronic intermittent hypoxia on the jaw muscle electromyographic activities during sleep in young adult rats.
  Obstructive sleep apnea (OSA) is associated with increased jaw muscle activity during sleep across a wide age range from childhood to adulthood. However, the contribution of intermittent hypoxia to jaw muscle activity remains unclear. We hypothesized that chro…
  europepmc 2026 置信度 0.80
• Guillain-Barré syndrome associated with Toscana Virus infection: a molecularly supported case and literature review.
  europepmc 2026 置信度 0.80
• Opposing Control of the Respiratory Brainstem on Multiple Timescales Achieved by Noradrenaline and Glutamate Release from the Locus Ceruleus.
  The locus ceruleus (LC) provides widespread noradrenergic (NAergic) modulation throughout the brain to influence a wide range of functions, including breathing. Although both anatomical and physiological evidence supports the involvement of the LC in both the …
  europepmc 2026 置信度 0.80
• Emergence of Behavioral Tinnitus in Gerbils Is Associated with Reduced Spontaneous Rates in Single Auditory Nerve Fibers.
  Tinnitus is often initiated by damage to the peripheral auditory system, for example, by acoustic overexposure. Animal studies have shown that such noise-induced tinnitus is related to increased spontaneous activity in the dorsal cochlear nucleus as well as fu…
  europepmc 2026 置信度 0.80
• Dynamics of Dentate Gyrus Place Cells and Dentate Spikes during Spatial and Nonspatial Changes in Environments.
  The dentate gyrus (DG) is thought to play a key role in the formation of dissociable memory representations for similar contexts. Neurons in the DG receive highly processed spatial and nonspatial sensory information from the medial and lateral entorhinal corti…
  europepmc 2026 置信度 0.80
• Corrigendum to "Human peripheral nerve xenografts and rat peripheral nerve allografts implanted to the striatum: Methodology and initial findings of cell-based therapy" [J. Neurosci. Methods 434 (2026) 110825].
  europepmc 2026 置信度 0.80
• A Bayesian Spatiotemporal Model for Joint Estimation of Brain Activation and Connectivity in fMRI Studies.
  Task-based functional magnetic resonance imaging (fMRI) experiments play a crucial role in modern data-driven neuroscience research. These studies often aim to understand how external stimuli trigger activation in specific brain regions and to explore function…
  europepmc 2026 置信度 0.80
• Introduction to special issue: decision neuroscience and aging.
  europepmc 2026 置信度 0.80
• Network-oriented neurorehabilitation after stroke: a paradigmatic approach.
  Stroke recovery increasingly demands a reconceptualization of the brain as a dynamic network system. This opinion paper advocates for a network-oriented neurorehabilitation paradigm, grounded in the understanding that functional recovery relies on the reorgani…
  europepmc 2026 置信度 0.80
• A multi-band spatial asymmetry convolutional neural network for EEG-based emotion recognition.
  Emotion recognition is an important component for enabling machines to perceive and respond to human emotions. Existing electroencephalogram (EEG)-based emotion recognition methods often rely on single-band signals or purely spatial representations, which may …
  europepmc 2026 置信度 0.80
• Newborn screening for spinal muscular atrophy: time is motor neuron.
  europepmc 2026 置信度 0.80
• Structural and dynamical strategies to prevent runaway excitation in reservoir computing.
  Reservoirs, typically implemented as recurrent neural networks (RNNs) with fixed random connection weights, can be combined with a simple trained readout layer to perform a wide range of computational tasks. However, increasing the magnitude of reservoir conne…
  pubmed Metzner C, Schilling A, Maier A, Kinfe T 等 2026 置信度 0.82
• Precision meets plasticity: engineering and neurobiological frontiers of low-intensity focused ultrasound neuromodulation.
  Low-intensity focused ultrasound (LIFU) is emerging as a promising non-invasive tool for neuromodulation, with the potential to reach deep brain structures implicated in psychiatric and neurodegenerative disorders. Despite its rapid development, the translatio…
  europepmc 2026 置信度 0.80
• Microbial neuroscience: The gut microbiota as a cognitive layer.
  Cognition is traditionally viewed as a brain-centred process, with gut microbes treated primarily as modulators of physiology and behaviour. Recent advances in microbiome research suggest that microbial communities can exhibit history-dependent functional stat…
  europepmc 2026 置信度 0.80
• Multi-omics integration identifies VIM and LGALS3 as apoptosis-associated genes in astrocytes after traumatic brain injury.
  Apoptosis contributes substantially to neurological deficits after traumatic brain injury (TBI), yet the molecular drivers and cellular regulation of astrocyte-associated apoptosis remain poorly defined. We integrated bulk RNA-seq, single-cell RNA-seq, and spa…
  europepmc 2026 置信度 0.80
• Early correlates of visual awareness are affected by self-related information.
  Self-related cues, most notably one's own face, are highly salient and confer processing advantages at both conscious and unconscious levels. Whether such self-related information and stimulus salience modulate the earliest electroencephalography (EEG) correla…
  europepmc 2026 置信度 0.80
• Protocol for live-imaging of blood flow and vascular permeability in zebrafish larvae.
  Cerebral vascular dynamics are critical to maintain brain homeostasis, and the fenestrated capillaries of the hypophysis (also known as the pituitary) exhibit unique structural and functional features that support brain-to-periphery neuroendocrine communicatio…
  europepmc 2026 置信度 0.80
• The Dendrites Decide: Divergent Computation Strategies Define Prefrontal Layer 5 Pyramidal Subtypes.
  The brain contains a remarkable diversity of neuronal cell types, whose functional roles are shaped by differences in molecular identity, morphology, connectivity, and intrinsic electrophysiological properties. Understanding how these features shape the integr…
  europepmc 2026 置信度 0.80
• Surgical Site Infections After External Ventricular Drain Placement: Incidence, Patient-Related, and Periprocedural Risk Factors.
  External ventricular drain (EVD) placement is a routine neurosurgical procedure for cerebrospinal fluid (CSF) diversion. Despite standardized procedures, a considerable risk of infection remains. While CSF EVD-related infections (EVD-RI) are common and have be…
  pubmed Alakmeh A, de Wilde D, Stumpo V, Voglis S 等 2026 置信度 0.82
• Randomised superiority trial evaluating an online transdiagnostic emotion regulation treatment for adolescents with mental health conditions: study protocol.
  Introduction Mental health conditions are prevalent during adolescence, but access to early evidence-based treatments remains limited. Scalable, online, theory-based transdiagnostic interventions delivered in primary care have the potential to reduce this trea…
  europepmc 2026 置信度 0.80
• Electroencephalographic evidence of cortical network disruption preceding overt cardioinhibition during tilt-induced reflex syncope.
  Objective Reflex syncope is a common cause of transient loss of consciousness. However, the early cerebral mechanisms underlying cardiovascular changes remain poorly understood. Our objective was to investigate early cerebral changes by quantitatively analyzin…
  europepmc 2026 置信度 0.80
• An improved combination of T1-weighted and FLAIR contrasts for myelin water imaging.
  In vivo myelin imaging often requires long and dedicated MRI scanning techniques. Combining conventional T1-weighted and FLAIR images into the T1w/FLAIR-ratio has been proposed as a myelin-sensitive proxy, however its sensitivity is debated. In this study, we …
  europepmc 2026 置信度 0.80
• Neuroscience in pictures: Bipolar disorder.
  Bipolar disorder is a chronic, episodic mood illness characterized by recurrent oscillations between mania, depression, and euthymia, affecting an estimated 2.4% of the global population. This pictorial review explores its pathophysiology through the case of a…
  europepmc 2026 置信度 0.80
• Low-dose ionizing radiation and cognitive function: evidence, mechanisms, and controversies.
  Humans are chronically exposed to ionizing radiation. Natural background radiation is generally harmless, yet potential risks arise from nuclear accidents, accidental medical irradiation, and high-background-radiation regions. The effects of high-dose radiatio…
  europepmc 2026 置信度 0.80
• Correction: Cognitive state monitoring for neuroadaptive information visualization.
  [This corrects the article DOI: 10.3389/fnhum.2026.1793651.].
  europepmc 2026 置信度 0.80
• A systematic review of human avoidance learning: Cognition, computation, and methods.
  Avoidance behaviour is fundamental for survival but can become maladaptive in clinical conditions. A large body of literature has accumulated on the dynamics of human avoidance learning. However, current theories and overviews do not provide an exhaustive acco…
  europepmc 2026 置信度 0.80
• Repetitive Transcranial Magnetic Stimulation over Right PMd Does Not Affect the Stability of Rhythmic Bimanual Finger Movements.
  How the brain controls rhythmic asymmetric bimanual movements remains an enduring question in neuroscience. Prior research suggests that the right dorsal premotor cortex (PMd) is essential for maintaining asymmetric bimanual rhythmic finger-tapping patterns. H…
  europepmc 2026 置信度 0.80
• WAC loss alters food-associated behavior and physiological homeostasis with stage-associated cholinergic dysregulation in Caenorhabditis elegans.
  WAC is a chromatin-associated regulatory protein involved in transcriptional control and has been identified as an autism-associated gene in human genetic studies. However, its functional role in regulating behavior and synaptic processes remains incompletely …
  europepmc 2026 置信度 0.80
• When rank meets identity: the neural basis of social rank and group identity integration.
  Group identity and social rank are fundamental, interacting dimensions of interpersonal relationships, yet their integrative neural representations remain poorly understood. This study bridges this gap using an experimental design that simultaneously manipulat…
  europepmc 2026 置信度 0.80
• Identifying candidate therapeutic targets in amyotrophic lateral sclerosis through a transcriptome-wide machine-learning consensus approach for drug repurposing.
  Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease for which effective disease-modifying therapies remain limited. This study aimed to derive internally recurrent ALS-associated transcriptional signatures and generate directionall…
  europepmc 2026 置信度 0.80
• Gate Metal-Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems.
  Intrinsically stretchable devices capable of integrating sensing, memory and signal processing are highly desirable for conformal bioelectronics. However, achieving such multifunctionality remains challenging due to conflicting operational requirements and the…
  pubmed Yoon J, Jang J, Jung H, Seong D 等 2026 Aug 30 置信度 0.82
• Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression.
  Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p-tau217) in Alzheimer's disease (AD) remains uncertain.
  pubmed Lan G, Liao W, Jiang M, Zhu J 等 2026 Sep 置信度 0.82
• A Novel Sparse Cellular Labeling System with Tunable Gradients and Long-Term Stability.
  The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dyna…
  pubmed Tang X, Hou Z, Lu L, Song Y 等 2026 Aug 30 置信度 0.82
• Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease.
  Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear.
  pubmed Sun W, Yang B, Zheng H, Wang Q 等 2026 Sep 置信度 0.82
• Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk.
  Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%-13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026…
  pubmed Forslund M, Melin J, Joham AE, Piltonen TT 等 2026 Aug 30 置信度 0.82
• Cerebral Cortical Structural Variation and General Cognitive Ability: Evidence From Mendelian Randomization.
  Understanding the cortical architecture underlying individual differences in general cognitive ability (GCA) remains a central question in cognitive neuroscience. Prior work has established associations between global brain size and GCA, yet the regional effec…
  pubmed Chou CJ, Fiecas M, Del Re EC, Vuoksimaa E 等 2026 Sep 置信度 0.82
• Corrigendum to "Innovation and sustainability in immune-mediated diseases: An Italian multidisciplinary consensus across gastroenterology, dermatology, and rheumatology" [Digestive and Liver Disease 58 (2026) 1051-1060].
  pubmed Scaldaferri F, Vincenzo FD, Falco GM, Lazzaro FG 等 2026 Aug 30 置信度 0.82
• Erratum to: Diagnostics of Synucleinopathies by Protein Amplification Methods: Methodological and Bibliometric Analysis.
  pubmed Groshkov AA, Kolotyeva NA, Tregub PP, Zhdankina VI 等 2026 Aug 置信度 0.82
• Effect of Cu(2+) on the Nucleoli of Cultured Astrocytes from the Rat Cerebral Cortex.
  Cultured astrocytes were incubated with CuCl 2 , which caused dose-dependent cell death (25-200 μM, 24 h). Immunocytochemical detection of the nucleolar protein nucleophosmin/B23 (NPM/B23) demonstrated that exposure to Cu 2+ (100 μM,…
  pubmed Genrikhs EE, Stelmashook EV, Smirnova EA, Golyshev SA 等 2026 Aug 置信度 0.82
• Genetic and Molecular Basis of Cone Opsin Phototransduction.
  The vertebrate visual system contains a sophisticated physiological assembly of highly-specialized proteins that mediate light stimuli to be processed by the brain. Two types of cells, the rod and cone cells, are involved in detecting dim and bright light, res…
  pubmed Cao H, Puig-Puig N, Cruz A, Koch KW 等 2026 Aug 置信度 0.82
• Virtual Reality in Surgical Training: A Comprehensive Study on Educational Efficacy, Memory Enhancement, and Mental State for Clinical Clerkship Students.
  Virtual Reality (VR) is increasingly used in surgical education. This study examines the impact of VR-integrated training on learning, memory, and psychological responses. A prototype VR system with immersive OR views was tested on 67 clinical clerkship studen…
  pubmed Nanashima A, Hirano Y, Kubo H, Tamura S 等 2026 Aug 31 置信度 0.82
• Behavioral and spectral electroencephalographic biomarkers of epileptogenesis, disease progression, and drug resistance in a longitudinal lithium-pilocarpine model of temporal lobe epilepsy.
  Temporal lobe epilepsy (TLE) is linked to progressive alterations in brain network dynamics, leading to behavioral comorbidities and emergence of drug resistance; yet the underlying mechanistic and synaptic substrates remain incompletely understood. Here, we p…
  pubmed Urone G, Ricciardi N, Scordino M, Giglia G 等 2026 Aug 30 置信度 0.82
• Ten days of voluntary wheel running prior to streptozotocin is sufficient to blunt induction of hyperglycemia in male C57BL/6J mice.
  Diabetes is a chronic disease characterized by hyperglycemia. It is associated with a variety of co-morbidities, including depression. This link is likely mediated in part by hyperglycemia-induced increases in inflammation. Given that exercise can benefit diab…
  pubmed Reese GA, Kusumo LE, Johnson M, Burley S 等 2026 Aug 30 置信度 0.82
• Hippocampal synaptic transmission and Ca(2)⁺ signaling are altered by the selective 5-HT(2A) receptor agonist, 25CN-NBOH.
  Classical psychedelics exert therapeutic effects on affective disorders, with serotonin 5-HT 2A receptor activation thought to play a central role. The cellular mechanisms by which 5-HT 2A signaling modulates neural circuits remain incompletely understood and …
  pubmed Wang Y, Karaca SC, Rasmussen MD, Kristensen JL 等 2026 Aug 30 置信度 0.82
• Incubation of cocaine craving is associated with reduced context-induced Fos expression in parvalbumin interneurons in the nucleus accumbens core of male rats.
  Substance use disorder develops in a subset of individuals after repeated drug exposure and is characterized by escalating intake and loss of control over use. Rodent self-administration protocols with varying drug access durations are used to study controlled…
  pubmed Anesio A, Lopes Costa GV, Palombo P, Zaniboni CR 等 2026 Aug 30 置信度 0.82
• Representation of arousal states by temporal dynamics of brain-wide traveling wave patterns in resting-state fMRI.
  As traveling waves mediate neural information processing that depends on arousal states, we hypothesized that traveling waves would represent arousal states. To investigate this, we aimed to analyze brain-wide patterns of traveling waves during resting states …
  pubmed Sihn D, Kim J, Kim SP 2026 Aug 30 置信度 0.82
• The appetite for freediving differs between Sprague-Dawley and Long Evans rats.
  Freediving in rats has emerged as a relevant model to study physiology and neural adaptation underlying submersion mechanisms. However, despite well-established strain-dependent differences in behavior and physiological responses, most studies about freediving…
  pubmed Chambrun L, Kamda JLD, Vatrinet L, Foyet HS 等 2026 Aug 30 置信度 0.82
• Associations of domain-specific cognitive function with all-cause mortality over 11 years: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.
  Poor cognitive function is associated with increased mortality; however, whether these associations are consistent across different cognitive domains remains incompletely understood.
  pubmed Mehta K, Magliano DJ, George R, Barr ELM 等 2026 Aug 19 置信度 0.82
• National survey of patients with neuromuscular disease and COVID-19 in Japan.
  Coronavirus disease 2019 (COVID-19) poses particular risks for patients with neuromuscular disorders, but its severity and outcomes in this population remain unclear. We investigated the clinical features, transmission routes, treatments, and prognostic factor…
  pubmed Sato T, Ishigaki K, Kihara Y, Ishiguro K 等 2026 Aug 30 置信度 0.82
• Disrupted Functional Network Organization in Crohn's Disease: Interoceptive Alterations Linked to Anxiety.
  How Crohn's disease alters large-scale brain network organization and interacts with affective symptoms remains poorly understood. We aimed to characterize disease-related disruptions in functional topology, rich-club organization, and hierarchical gradients, …
  pubmed Xu S, Bao C, Zhu X, Wang Q 等 2026 Sep 置信度 0.82
• Thrombus Metabolism-Based Molecular Subtyping for Prognostic Risk Stratification in Acute Ischemic Stroke: A Preliminary Study.
  To preliminarily characterize metabolic molecular subtypes of cerebral thromboemboli and evaluate their clinical significance in anterior circulation acute ischemic stroke due to large vessel occlusion (AIS-LVO).
  pubmed Lu T, Li W, Cao W, Liu Y 等 2026 Sep 置信度 0.82
• Cardiovascular Prevention among Healthcare Professionals: the ESC Congress Cardiovascular Health Check 2025.
  Healthcare professionals (HCPs) play a central role in preventive care, yet their own cardiovascular health management remains poorly characterised. We evaluated cardiovascular risk profiles, awareness, treatment use, target achievement and subclinical atheros…
  pubmed Wenzl FA, Wang Y, Mass V, Stæger FF 等 2026 Aug 30 置信度 0.82
• CX3CL1/CX3CR1 signaling in spinal metastasis: mechanisms and translational opportunities.
  Spinal metastases are a common and morbid complication of advanced malignancies. While vertebral involvement is often attributed to anatomical factors, emerging evidence implicates the chemokine CX3CL1 and its receptor in guiding tumor cells to the spine and r…
  pubmed Sanker V, Li Z, Urdaneta A, Dravid A 等 2026 Aug 30 置信度 0.82
• APOE in subjective cognitive decline: a systematic review and meta-analysis.
  Alzheimer's disease (AD) is increasingly conceptualised as a biological and clinical continuum that includes Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and overt dementia. We conducted a systematic review and meta-analysis to assess t…
  pubmed Alonge P, Baiamonte L, Gerardi G, Torrente A 等 2026 Aug 30 置信度 0.82
• Efficacy of the 'Quarter-of-an-Hour-Rule' Single Instruction Derived from Stimulus Control Therapy for Insomnia: A Pragmatic Open-Label, Randomized Controlled Trial.
  This study explored the preliminary effects of the quarter-of-an-hour-rule (QHR), a single instructional element of stimulus control therapy (SCT) for insomnia.
  pubmed Espie CA, Tse KYK, Malaffo M 2026 Aug 30 置信度 0.82
• Development of a novel analytical pipeline to characterize morphological and molecular features of blood vessels within marginal regions of glioblastoma.
  Glioblastomas (GBM) are highly invasive tumors with marginal regions comprising unresectable functional brain infiltrated by tumor cells. Effective drug delivery to these regions is crucial, but lack of understanding of the structural and functional characteri…
  pubmed Das A, Vallatos A, Birch J, Ireson C 等 2026 Jan-Dec 置信度 0.82
• Assessing Outcome of tPA Therapy in Patients with Acute Ischemic Stroke (0-three hours).
  To determine the frequency of good functional outcome and significant neurological improvement for patients treated with tPA within first three hours of onset of acute ischemic stroke.
  pubmed Tariq A, Aslam MA, Bashir Q, Nayab S 等 2026 Aug 置信度 0.82
• Patient-Reported Complications and Outcomes of General, Central Neuraxial, and Peripheral Regional Anesthesia in Charcot-Marie-Tooth Disease.
  Anesthetic management for Charcot-Marie-Tooth disease (CMT) is still controversial and source of concerns for both anesthetists and patients. We explored the frequency of self-reported complications following anesthesia in a large cohort of patients with CMT c…
  pubmed Bertini A, Gemma M, Manganelli F, Previtali SC 等 2026 Oct 置信度 0.82
• Rare Presentation of Parsonage-Turner Syndrome Post Tdap Vaccination: A Case Report.
  Parsonage-Turner Syndrome (PTS) is a rare disorder of the brachial plexus typically characterized by acute shoulder and/or upper extremity pain, followed by muscle weakness. Though the specific etiology of PTS is unclear, numerous associations are cited in the…
  pubmed Jervis M, Dunn-Pirio A 2026 Jul 置信度 0.82
• Prenatal environmental determinants of aromatase brain-promoter methylation in cord blood: chemical, airborne, pharmacological, and nutritional factors.
  Aromatase, an enzyme encoded by the gene CYP19A1 , plays central roles in neurodevelopment. In the brain, its function is to convert androgens into neuroestrogens, ensuring balanced hormonal signalling. Both animal experiments and human studies have shown that…
  pubmed Tanner S, Drummond K, Thomson S, Vacy K 等 2026 置信度 0.82
• The High Cost of Misdiagnosis: The Challenges of Differentiating Grade-4 Astrocytoma from Glioblastoma in Resource-Constrained Countries.
  pubmed Saeed H, Qadri HM 2026 Aug 置信度 0.82
• MicroRNA-sensing plasmid system for dynamic control of functional ion channel expression.
  Gene therapy offers the potential for long-term treatment of a range of chronic diseases. However, permanent gene therapy expression may not be desirable. Efforts have been made to create systems that can be switched on/off by stimuli including light, designer…
  pubmed Geuter J, Austin TT, Corke J, Tian N 等 2026 Sep 8 置信度 0.82
• Deep learning in imaging analysis for multiple sclerosis: Diagnosis and monitoring.
  Multiple sclerosis (MS) is an autoimmune disease that affects various parts of the central nervous system and often occurs in young population (between 20-40 years old). Given that MS is a lifelong disease and there is currently no definitive treatment for MS,…
  pubmed Naser Moghadasi A, Owji M, Rezaeimanesh N 2026 置信度 0.82
• Development and Content Validation of the Questionnaire for Postamputation Pain (Q-PAP): An Expert Delphi Study.
  The questionnaire for postamputation pain (Q-PAP) introduced here has undergone modifications over a decade of research on postamputation pain. It has so far been used as a form of study specific questionnaire. Here, we present the latest attempt to consolidat…
  pubmed Ortiz-Catalan M, Limakatso K 2026 Jan-Dec 置信度 0.82
• Collagen-based dressings for diabetic foot ulcers: A systematic review.
  To evaluate the efficacy and safety of collagen-based dressings in the management of diabetic foot ulcers (DFUs), compared to standard wound care (SWC), human amniotic membrane allografts (hAMA), and decellularized extracellular matrix (dECM) products.
  pubmed Rahimi S, Hosseingholizade M, Hashemi-Madani N, Emami Z 等 2026 置信度 0.82
• Ultraslow brain dynamics as neurophysiological markers of information sampling during learning.
  To learn, we must actively sample information from our environment: selecting, prioritizing, and extracting relevant cues. Here, we investigated whether ultraslow event-related potentials (ERPs) could track information sampling as participants learned new word…
  pubmed León-Cabrera P, Prunell-Castañé A, Münte TF, Wang S 等 2026 Sep 18 置信度 0.82
• Uridine and pyruvate supplementation is associated with Th1 polarization during mitotoxic antibiotic therapy.
  Antibiotics with off-target mitochondrial toxicity can impair host immunity, yet their impact on human adaptive immunity in vivo remains unclear. Because T cell activation and differentiation depend on mitochondrial metabolism, antibiotic-induced mitochondrial…
  pubmed De Santis S, Rutigliano M, Simone F, Larocca L 等 2026 Sep 18 置信度 0.82
• Symmetry in the Enlargement Rates of Large Hypertransmission Defects between Eyes in Age-Related Macular Degeneration.
  The symmetry of macular atrophy growth rates between eyes of patients with bilateral nonexudative age-related macular degeneration (AMD) was assessed to determine if both eyes could be used in clinical trials to test therapies that might slow the growth of atr…
  pubmed Beqiri S, Herrera G, Shen M, Berni A 等 2026 Oct 置信度 0.82
• Cognitive decline in psychotic disorders: A longitudinal matched case-control study.
  Patients with psychotic disorders often exhibit premorbid cognitive deficits and future cognitive changes following the onset of illness. This study examined cognitive trajectories in schizophrenia (SCZ), schizoaffective disorder (SZA) and bipolar disorder (BD…
  pubmed Cohen N, Werbeloff N, Tatsa-Laur L, Beer ZA 等 2026 Sep 置信度 0.82
• Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial.
  Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related qua…
  pubmed Pedro KM, Alvi MA, Lozano C, Karthikeyan V 等 2026 Sep 置信度 0.82
• Platelet activation and thrombosis in microvascular obstruction.
  Microvascular obstruction (MVO) remains a major complication following coronary reperfusion, but its pathogenesis is poorly defined. We evaluated myocardial platelet activation and thrombosis using fluorine-18-labelled GP1 ([18F]GP1) positron emission tomograp…
  pubmed Balmforth C, Giaj Levra A, Whittington B, Morgan A 等 2026 Aug 30 置信度 0.82
• Preoperative Moderate-Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients.
  Excessive daytime sleepiness may reflect increased vulnerability to postoperative neurocognitive disorders given its association with neurodegenerative disease, cognitive decline, and dementia. However, the role of excessive daytime sleepiness in postoperative…
  pubmed Devinney MJ, Takla J, VanDusen K, Wright MC 等 2026 Aug 30 置信度 0.82
• A randomized crossover trial comparing the acute physiological and psychological effects of botanical formulations of oral psilocybin, oral psilocin, and sublingual psilocin.
  Psilocybin, a serotonergic psychedelic found in hallucinogenic mushrooms, is metabolized to psilocin, the compound responsible for its psychoactive effects. Psilocybin has demonstrated therapeutic potential for neuropsychiatric conditions. While recent trials …
  pubmed Tai ML, Szigeti B, Downey AE, Aday JS 等 2026 Aug 29 置信度 0.82
• Evaluating seltorexant as a treatment option for major depressive disorder.
  Major depressive disorder is a leading cause of disability, with a significant rate of patients responding inadequately to antidepressants, and residual symptoms, including insomnia, worsening overall outcomes. Current adjunctive options display partial effica…
  pubmed Di Nicola M, Pepe M, Marcelli I, Panaccione I 等 2026 Aug 29 置信度 0.82
• DNA methylation profiling identifies long-range epigenetic silencing of clustered protocadherins as a key determinant of meningioma progression.
  Meningioma is the most common primary brain tumour in adults. However, molecular drivers of progression occurring in a subset of meningiomas are poorly understood. We hypothesise that epigenomic variations are causal for the clinical heterogeneity of meningiom…
  pubmed Merk DJ, Paßlack P, Surender S, Tsiami F 等 2026 Aug 29 置信度 0.82
• Prefrontal-thalamic goal states organize spatially aligned hippocampal maps.
  Animals repeatedly traverse the same environment to pursue different goals, yet the hippocampus must preserve a stable spatial map while keeping individual experiences distinct. Here we show that, when male rats navigate the same maze under different goal conf…
  pubmed Golipour Z, Mozaffarilegha M, Yen SF, Üstüner C 等 2026 Aug 29 置信度 0.82
• Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort.
  Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratifie…
  pubmed Farassat N, Reisert M, Rospleszcz S, Rod JE 等 2026 Aug 29 置信度 0.82