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This chapter explores the processes of neurogenesis and migration in the developing brain. It explains how neural cells are generated in specific regions and migrate over long distances to their final destinations, which is essential for brain function. The ch…
crossref
S. Marc Breedlove
2026-04-23T10:45:14Z
置信度 0.70
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Abstract Objective: Olfactory dysfunction (OD) is a common symptom of allergic rhinitis (AR) that significantly impairs quality of life, yet its underlying mechanisms remain unclear. This study investigated the role of olfactory bulb neurogenesis mediated by o…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis is essential for learning, memory, and mood regulation, and its disruption is implicated in ageing, neurodegeneration, and mood disorders. However, the mechanisms linking inflammation to adult hippocampal neurogenesis impairment …
europepmc
2026
置信度 0.80
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder lacking effective disease-modifying therapies. A promising regenerative approach involves enhancing endogenous neurogenic capacity within the injured brain. Reactive astrocytes-stellate-like …
europepmc
2026
置信度 0.80
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Adult neurogenesis is predominantly restricted to two neurogenic regions in the mammalian brain: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG) within the hippocampus. The hippocampus serves as a…
europepmc
2026
置信度 0.80
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The hypothalamic radial-glia-like tanycyte population plays important and intertwined roles in metabolism, reproduction, and seasonality. Although these processes are circadian-regulated, the role of the molecular clock in tanycytes themselves has not yet been…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis (AHN), the generation of new neurons in the dentate gyrus of the hippocampus, is a dynamic and tightly regulated process essential for memory encoding, regulation of emotions, and cognitive flexibility. While the molecular and bi…
europepmc
2026
置信度 0.80
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ABSTRACT After spinal injury, zebrafish, in contrast to mammals, show regenerative neurogenesis, characterized by enhanced injury-induced proliferation of ependymo-radial glial cells (ERGs) and an increase in injury-induced generation of neurons from these pro…
europepmc
2026
置信度 0.80
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Neurogenesis, a critical process implicated in diverse brain disorders, is greatly diminished in the adult human brain, complicating direct investigations into its mechanistic role in disease. In the olfactory epithelium (OE), olfactory sensory neurons (OSNs) …
europepmc
2026
置信度 0.80
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Prolonged glucocorticoid elevation is strongly associated with brain dysfunction and the pathogenesis of stress-related disorders, including several psychiatric disorders. Elevated lactate levels have been reported in the brains of patients with psychiatric di…
europepmc
2026
置信度 0.80
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Neurogenesis is characterized by dynamic structural changes and functional remodeling of multiple organelles, which interact to form an intricate network that precisely modulates processes including neural progenitor cell self-renewal, neurogenesis, and termin…
europepmc
2026
置信度 0.80
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Ayurvedic medicine, an ancient Indian health system, promotes a category of Ayurvedic herbs (AH) known as Medhya Rasayanas (nootropic rejuvenators) for cognitive enhancement and neuroprotection. Currently, AH are increasingly being studied for their potential …
europepmc
2026
置信度 0.80
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Histone proteins, which reside in the nuclei of eukaryotic cells, are involved in diverse cellular processes. The core histone H4 serves as a structural component of the nucleosome. Patients carrying mutations in H4Clustered histone ( H4C ) genes exhibit a bro…
europepmc
2026
置信度 0.80
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Neonicotinoid insecticides, particularly imidacloprid, are widely used worldwide and have raised increasing concerns regarding their potential developmental neurotoxicity. However, data on the effects of imidacloprid exposure during early embryogenesis, especi…
europepmc
2026
置信度 0.80
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Hypothalamic adult neurogenesis is implicated in energy homeostasis; however, the impact of physical exercise, particularly under high-fat diet (HFD) conditions, on this process remains unclear. To address this, we subjected mice to short-term and long-term vo…
europepmc
2026
置信度 0.80
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Objective Neuroinflammation plays a pivotal role in the pathogenesis of autism spectrum disorder (ASD) and represents a potential therapeutic target. Salidroside (SLDS), a bioactive compound isolated from Rhodiola rosea L., exhibits potent anti-inflammatory an…
europepmc
2026
置信度 0.80
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Introduction Neurogenesis takes place in the subventricular zone (SVZ) and in the dentate gyrus (DG) of the hippocampus of many adult mammalian species. Recent findings indicate that calpain-2 could participate in neurogenesis regulation through the truncation…
europepmc
2026
置信度 0.80
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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor originally characterized as a mediator of xenobiotic detoxification. Growing evidence now establishes AhR as a central integrator of metabolic, immune, and environmental signals in …
europepmc
2026
置信度 0.80
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Chronic diabetic wounds remain a major clinical challenge due to persistent inflammation, impaired neuro-immune crosstalk, and dysregulated macrophage polarization. Here, we report an injectable, ultrasound (US)-activated piezoelectric hydrogel that programmab…
europepmc
2026
置信度 0.80
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The field of human adult neurogenesis has been controversial despite mounting evidence. The authors propose moving beyond debating the existence of adult neurogenesis and towards discovering strategies to harness endogenous stem cell potential for resilience a…
europepmc
2026
置信度 0.80
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Cadmium (Cd) is a pervasive environmental heavy metal associated with impaired hippocampal neurogenesis, yet the molecular mechanisms linking chronic low-dose exposure to disrupted neuronal differentiation remain incompletely understood. In particular, whether…
europepmc
2026
置信度 0.80
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Although olfactory dysfunction (OD) is common worldwide, there is insufficient information about its pathophysiology and treatment. Alpha-melanocyte-stimulating hormone (α-MSH) has anti-inflammatory and neuroprotective properties and has been suggested to prom…
europepmc
2026
置信度 0.80
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Zebrafish, in contrast to mammals, regenerate neurons after spinal cord injury, but little is known about the control mechanisms of this process. Here we use scRNA-seq and in vivo experiments to show that sema4ab, mainly expressed by lesion-reactive microglia,…
europepmc
2026
置信度 0.80
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As complex individualized behaviors in mice arise even when genes and environment are held constant, emerging social group structures should also depend on individual behavior. Adult hippocampal neurogenesis drives individual behavior and is involved in certai…
europepmc
2026
置信度 0.80
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Ethnopharmacological relevance The seeds of Cuscuta chinensis Lam. (CCL) are commonly used in traditional Chinese medicine to strengthen kidney qi and alleviate mental fatigue as well as mood dysregulation and affective disturbances. Total organic acids, as ma…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis is essential for learning, memory, and structural plasticity, yet the mechanisms through which physical neuromodulatory stimuli regulate this process remain incompletely understood. Here, we investigated whether transcranial low-…
europepmc
2026
置信度 0.80
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Early-life manganese (Mn) overexposure induces cognitive flexibility impairments by disrupting hippocampal neurogenesis and decreasing neural stem cells (NSCs) differentiation into neuroblasts. CDC25B is a key regulator required for both the cell cycle and NSC…
europepmc
2026
置信度 0.80
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ABSTRACT RNA-binding proteins (RBPs) play vital roles in regulation of cell fate and function. Here, we introduce Switch-TRIBE, which conditionally tags endogenous RBPs with the adenosine deaminase catalytic domain to detect physiological RBP-RNA interactions.…
europepmc
2026
置信度 0.80
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Abstract In the adult hippocampus, neural progenitor cells (NPCs) proliferate before undergoing differentiation, maturation, and incorporation into the hippocampal neurocircuitry, where they contribute to diverse learning and memory processes that can be pertu…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis persists throughout the human lifespan, yet declines in Alzheimer's disease and major depression, associated in part with reduced brain-derived neurotrophic factor (BDNF) levels. For rodents, environmental enrichment, dichotomise…
europepmc
2026
置信度 0.80
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Despite major advances in the study of cerebellar neurogenesis, cerebellar angiogenesis during embryogenesis remains poorly described. Recent advances in tissue clearing, light-sheet microscopy, and artificial intelligence have increasingly enabled detailed 3D…
europepmc
2026
置信度 0.80
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Interleukin-1 (IL-1) signaling is a major driver of post-ischemic neuroinflammation, yet the cell- and isoform-specific roles of the two major IL-1 receptor type 1 agonists, IL-1α and IL-1β, remain incompletely defined in the context of stroke. Microglia rapid…
europepmc
2026
置信度 0.80
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Summary Neural stem cells (NSCs) sustain neurogenesis within specialized niches, yet how adhesion-dependent mechanisms during development control lifelong behavior remains unclear. Here, we identify Afadin , a core adherens junction protein, as a regulator. Do…
europepmc
2026
置信度 0.80
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Background and Purpose: Alterations of the brain ventricular system are recurrently observed in individuals with Alcohol Use Disorder (AUD) and in animal models of alcohol exposure. Lipid droplet (LD) accumulation in the ventricular system, a feature commonly …
europepmc
2026
置信度 0.80
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Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by progressive memory loss, cognitive decline, and emotional dysregulation. Adult hippocampal neurogenesis (AHN) critically contributes to cognition and mood but undergoes precipito…
europepmc
2026
置信度 0.80
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Abstract Neural stem cells (NSCs) sustain neurogenesis within specialized niches, yet how adhesion-dependent mechanisms during development control lifelong behavior remains unclear. Here, we identify Afadin, a core adherens junction protein, as a regulator. Do…
europepmc
2026
置信度 0.80
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WOREE and SCAR12 syndromes are rare neurodevelopmental disorders caused by WWOX mutations, severely impairing brain development. The pleiotropic nature of WWOX complicates identifying specific mechanisms, thus, the specific molecular pathways affected by WWOX …
europepmc
2026
置信度 0.80
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Background Adult hippocampal neurogenesis is altered after cerebral ischemia. Although stroke increases newborn neuron production, many cells display aberrant morphological and positional features that may impair functional integration and contribute to long-t…
europepmc
2026
置信度 0.80
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Radial glial progenitors (RGPs) generate all projection neurons (PNs) in the cerebral cortex through incompletely understood processes. We combined Mosaic Analysis with Double Markers at embryonic stages (E)12.5 and E13.5 with early postnatal callosal tracing …
europepmc
2026
置信度 0.80
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Adult neurogenesis in the dentate gyrus (DG) of the hippocampus is a dynamic and tightly regulated process that is finely regulated by a diverse array of transcription factors. While the transcription factor Etv5, a member of the Erythroblast Transformation Sp…
europepmc
2026
置信度 0.80
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In contemporary consumer products markets, organophosphorus flame retardants (OPFRs) are widely used, associated with non-carcinogenic health risks and exhibit multisystem toxicity. Based on the endocrine-disrupting properties, which are combined with the endo…
europepmc
2026
置信度 0.80
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Retinoic acid, acting through RAR/RXR nuclear receptors, is required for neuronal differentiation in Xenopus laevis. Bexarotene, characterised as a pan-RXR agonist, reduces the symptoms of Alzheimer's disease in mouse models by clearing amyloid plaque and by p…
europepmc
2026
置信度 0.80
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Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system, affecting both motor and non-motor systems. It's pathophysiology consists of a complicated process that needs to be analyzed carefully to comprehend and treat the condition…
europepmc
2026
置信度 0.80
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The Activity-Dependent Neuroprotective Protein (ADNP) is an important regulator of early brain development, especially during cortical neurogenesis and neurite formation. De novo point mutations or haploinsufficiency of the ADNP gene result in ADNP syndrome, w…
europepmc
2026
置信度 0.80
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Development of the mammalian neocortex relies on a tightly controlled schedule, wherein cortical progenitors initially expand by symmetric divisions, then sequentially generate neurons of the deep and superficial cortical layers by asymmetric divisions, and fi…
europepmc
2026
置信度 0.80
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Accumulating evidence indicates that adult hippocampal neurogenesis (AHN) undergoes heterogeneous alterations in depression, yet the underlying mechanisms remain incompletely understood. In this study, we established a corticosterone (CORT)-induced mouse model…
europepmc
2026
置信度 0.80
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Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demons…
europepmc
2026
置信度 0.80
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Dysfunction of neuronal networks such as aberrant excitability and disrupted oscillatory activity, especially within theta and gamma bands, in memory-related areas including the hippocampus and prefrontal cortex, is increasingly recognized as an important cont…
europepmc
2026
置信度 0.80
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Autism Spectrum Disorder (ASD) has been linked to disturbance of the coordinated transcriptional mechanisms that govern neurogenesis, neuronal differentiation, and synaptic maturation in human cortical development. Nevertheless, the regulatory networks and cel…
europepmc
2026
置信度 0.80
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The targeted differentiation of stem cell-like cells into functional neurons is a central goal in developmental biology and comparative neurobiology. In this study, we report for the first time on the successful neuronal remodeling of cell line derived from th…
europepmc
2026
置信度 0.80
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SUMMARY The mechanisms of the spinal cord regeneration after complete spinal cord transection were investigated in spiny mice. In some animals, the appearance of quadrupedal overground stepping together with rewiring of the direct propriospinal projections bet…
europepmc
2026
置信度 0.80
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Hilar mossy cells in the dentate gyrus project widely throughout the hippocampus, broadly contributing to circuit function. Their loss in disease is associated with local functional and structural rearrangements, including retrograde granule cell axon sproutin…
europepmc
2026
置信度 0.80
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The dentate gyrus is a critical hub for hippocampal-dependent memory and is distinguished by its capacity for lifelong neurogenesis, resulting in a heterogeneous population of granule cells generated across embryonic, postnatal, adolescent, and adult stages. A…
europepmc
2026
置信度 0.80
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Objectives : Alzheimer's disease (AD) is associated with impaired adult hippocampal neurogenesis (AHN). This study aimed to establish an in vitro model of Aβ 1-42 oligomer-damaged neural stem cells (NSCs) and to employ the 5×FAD mouse model of AD in vivo, and …
europepmc
2026
置信度 0.80
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Vascular dementia (VaD) is characterized by chronic cerebral hypoperfusion, leading to cognitive decline. Impaired hippocampal neurogenesis is a crucial pathological feature of VaD. Delta-like 1 homolog (Dlk1)-Notch signaling may contribute to neural stem cell…
europepmc
2026
置信度 0.80
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In the olfactory system, adult-neurogenesis results in the continuous reorganization of synaptic connections and network architecture throughout the animal's life. This poses a critical challenge: How does the olfactory system maintain stable representations o…
europepmc
2026
置信度 0.80
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Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy characterized by recurrent seizures, cognitive impairment, aberrant adult hippocampal neurogenesis, inhibitory circuit disruption, and persistent inflammatory remodeling. Current anti-seizure med…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis plays a central role in learning, memory formation, and adaptive neural plasticity, making it an attractive target for noninvasive neuromodulation strategies. Low-intensity focused ultrasound (LIFU) has emerged as a promising mod…
europepmc
2026
置信度 0.80
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Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder, with epidemiological studies consistently reporting a rising prevalence worldwide. Our previous human genetic sequencing analysis identified PRDM15 (PRDI-BF1 (Positive regu…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis is a major process of neuronal plasticity involved in mood regulation and memory and is tightly regulated by the neurogenic niche that relays signaling from the periphery. Neuroinflammation is principally mediated by microglia an…
europepmc
2026
置信度 0.80
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Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB 1 and CB 2 ) and adenosine 2A (A 2A ) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an int…
europepmc
2026
置信度 0.80
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The hippocampus is a principal brain region of adult neurogenesis and a key model for studying synaptic plasticity underlying learning and memory. Previously, our work suggested a role for the adaptor protein, PLEKHA2, in adult hippocampal neurogenesis; howeve…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis declines with age, but the stress pathways that shape neural precursor cell (NPC) survival and lineage progression remain incompletely understood. Here, we tested whether ferroptosis-related vulnerability contributes to the regul…
europepmc
2026
置信度 0.80
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Introduction DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) is a dosage-sensitive regulator of central nervous system development. Dysregulation contributes to major neurodevelopmental disorders, including Down Syndrome (DS), Autism Spe…
europepmc
2026
置信度 0.80
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Neurogenesis is the process by which new neurons are generated from neural stem cells (NSCs) and neural progenitor cells (NPCs). Impairment in this process can lead to cognitive and memory deficits, among other issues. Research indicates that defective neuroge…
europepmc
2026
置信度 0.80
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The ability to detect and adapt to changes in oxygen availability is essential for survival, especially in the mammalian brain, where oxygen demand is high and tightly regulated. Hypoxia-inducible factor 1 (HIF-1) is a key transcriptional regulator of oxygen h…
europepmc
2026
置信度 0.80
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Defining cell classes is central to the analysis of growing single-cell RNA sequencing (scRNA-seq) atlases. Marker genes are most often identified by differential expression (DE) methods that assess genes one at a time, ignoring the redundancy and complementar…
europepmc
2026
置信度 0.80
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Aims Smoking significantly impairs cognitive function and is a major risk factor for dementia, particularly when initiated during adolescence, a critical period for brain development. The glymphatic system, which is thought to participate in metabolic waste cl…
europepmc
2026
置信度 0.80
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One of the leading causes of morbidity and mortality in newborns and preterm infants is neonatal sepsis, which is defined as a systemic inflammatory response caused by a suspected or confirmed infection that occurs during the first month of life. Adolescents w…
europepmc
2026
置信度 0.80
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[This corrects the article DOI: 10.1016/j.mtbio.2024.101361.].
europepmc
2026
置信度 0.80
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Adult neural stem cells (aNSCs) of the lateral ventricular sub-ventricular zone (V-SVZ) are set aside during embryogenesis from a pool of slowly dividing neural stem/progenitor cells (NSPCs) residing in the lateral ganglionic eminence (LGE). The time of aNSCs …
europepmc
2026
置信度 0.80
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Neurogenesis and oligodendrogenesis occur throughout life under both physiological and pathophysiological conditions. Brain insults such as ischemia, trauma, epilepsy, or Alzheimer disease result in the promotion of neurogenesis and oligodendrogenesis; however…
europepmc
2026
置信度 0.80
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Serotonin (5-HT) modulates a wide variety of functions across the central nervous systems. It is a key regulator of neuroplasticity, particularly in the hippocampus, where increased serotonergic signaling generally enhances the plasticity processes. However, t…
europepmc
2026
置信度 0.80
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Factors regulating the genesis and expansion of basal progenitor cell sub-populations, including intermediate progenitor cells, are critical determinants of cortical neurogenesis and brain growth. Epigenetic (chromatin) marks have emerged as notable regulators…
europepmc
2026
置信度 0.80
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Background The sirtuin (SIRT) family of NAD⁺-dependent deacetylases has emerged as a central regulator in Alzheimer's disease (AD)-related pathophysiological pathways. However, the global publication landscape, research hotspots, and translational implications…
europepmc
2026
置信度 0.80
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Long noncoding RNA (lncRNA) Pnky is a trans-acting regulator of neural stem cell (NSC) differentiation, but the molecular mechanisms by which Pnky regulates neurogenesis are unknown. A fundamental step toward mechanistic understanding is to determine whether l…
europepmc
2026
置信度 0.80
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After injury, the repair of brain tissue is hindered by poor neuronal regeneration and severe neuroinflammation. Although magnetoelectric (ME) stimulation has emerged as a promising wireless strategy to promote axonal growth, its efficacy is strictly dependent…
europepmc
2026
置信度 0.80
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A major goal of spinal cord injury research is to develop a path to endogenous regeneration. This approach has been heavily informed by animal models of natural regeneration. An unresolved question is whether these models rebuild the spinal cord exclusively by…
europepmc
2026
置信度 0.80
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Post-traumatic epilepsy (PTE) is a debilitating long-term consequence of traumatic brain injury (TBI), yet the influence of age on epileptogenesis and neurological recovery remains insufficiently understood. Despite the high prevalence of TBI in the elderly, f…
europepmc
2026
置信度 0.80
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Brain dysfunction is a primary symptom of Gulf War illness (GWI). The present study investigated the effects of an amorphous formula of curcumin (CUR) and α-glycosyl isoquercitrin (AGIQ) on neurobehaviors and adult neurogenesis and following synaptic plasticit…
europepmc
2026
置信度 0.80
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Gestational diabetes mellitus (GDM) represents a prevalent pregnancy complication with long-term health implications for offspring. While metabolic outcomes have been extensively studied, sex-specific effects on neurodevelopment remain poorly understood. Here …
europepmc
2026
置信度 0.80
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ABSTRACT Pancreatic cancer (PC) exhibits a striking association with depression, with neuropsychiatric symptoms frequently preceding diagnosis. However, the biological mechanisms linking pancreatic tumor development to central nervous system dysfunction remain…
europepmc
2026
置信度 0.80
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The transcription factor REST (RE1-silencing transcription factor) is a key regulator of neuronal gene expression, playing a role in normal brain development and in the pathogenesis of central nervous system (CNS) tumors. By binding RE1 sequences and recruitin…
europepmc
2026
置信度 0.80
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Background Sleep deprivation (SD) is a potent trigger of anxiety and poses a substantial threat to mental health. Although accumulating evidence suggests that disrupted intestinal function contributes to abnormal behaviors associated with SD, the specific mech…
europepmc
2026
置信度 0.80
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Adult hippocampal neurogenesis is a metabolically demanding process requiring tight coordination between energy production and biosynthetic flux. Although voluntary running is a potent stimulus for this plasticity, the metabolic landscape sustaining the neurog…
europepmc
2026
置信度 0.80
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The hippocampus, essential for learning, memory, and affective regulation, is increasingly recognized as vulnerable to systemic and remote insults. Spinal cord injury (SCI), traditionally viewed as a motor-sensory disorder, can trigger widespread neurobiologic…
europepmc
2026
置信度 0.80
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Synthetic predator scents such as trimethylthiazoline (TMT) evoke innate fear responses in rodents, reflecting evolutionarily conserved defense mechanisms. Previous studies have shown that after repeated exposure to innate fear stimuli would induce adaptive pr…
europepmc
2026
置信度 0.80
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The dentate gyrus (DG) decorrelates entorhinal inputs (pattern separation); area CA3 completes partial cues via recurrent autoassociation. The density of CA3 recurrent connectivity is contested, with estimates from ∼ 0.9% (Guzman et al., 2016) to ∼ 9–11% (Samm…
europepmc
2026
置信度 0.80
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There are currently few promising approaches for treatment of photoreceptor pathologies: for example, gene therapy to augment or replace mutated genes, has proven successful in preclinical studies, and some of these therapies are moving towards the clinic. Ano…
europepmc
2026
置信度 0.80
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Chronic low-grade neuroinflammation contributes to inflammageing by compromising hippocampal plasticity, with interleukin-1β (IL-1β) as a key mediator. The extent to which sustained hippocampal inflammation can interfere with the potential beneficial effects o…
europepmc
2026
置信度 0.80
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Adult neurogenesis sustains olfactory function, facilitates the acquisition of new memories, and provides resilience against depression in mice. Neural stem cells (NSCs) elicit selective responses to different physiological and pathological stimuli, thereby mo…
europepmc
2026
置信度 0.80
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Tongqiao Huoxue Decoction (TQHXD), a representative traditional prescription for treating vascular blood stasis syndromes of the head and face, has been widely used in the management of ischemic stroke (IS). Our previous studies have demonstrated that TQHXD ac…
europepmc
2026
置信度 0.80
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Progressive neurodegeneration, decline in neurogenesis, and cognitive dysfunction alongside amyloid-β plaque and neurofibrillary tangle formation are prominent pathological features of Alzheimer's Disease (AD). Although the underlying mechanism remains unclear…
europepmc
2026
置信度 0.80
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Chronic l-methionine (l-met) treatment induces hyperhomocysteinemia, which impairs neurogenesis and memory by increasing oxidative stress. Caffeic acid (CA) possesses antioxidant properties that reduce brain oxidative damage and promote neurogenesis. This stud…
europepmc
2026
置信度 0.80
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Psilocin (4-hydroxy-N, N-dimethyltryptamine) is a substituted tryptamine alkaloid and a nonselective serotonergic agonist acting predominantly at 5-HT2A/C receptors, with substantial binding to 5-HT1A and 5-HT2B receptors. Microdosing is the practice of taking…
europepmc
2026
置信度 0.80
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Proper forebrain development relies on precise spatial and temporal control of early neural stem cell (NSC) proliferation and later neurogenesis. Brain malformations can arise when these processes are defective. Joubert Syndrome (JS) is a neurodevelopmental di…
europepmc
2026
置信度 0.80
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This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were randomized to RT or sedent…
europepmc
2026
置信度 0.80
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Adult-born hippocampal neurons are highly plastic but there remains uncertainty about the magnitude of neurogenesis and its long-term functional consequences. Theoretical predictions indicate that adult neurogenesis should lead to substantial growth of the den…
europepmc
2026
置信度 0.80
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Early human development is characterized by sensitive periods which impact long-term cognitive and behavioral outcomes. While these windows of heightened plasticity are well documented, the cellular mechanisms that enable and regulate them remain incompletely …
europepmc
2026
置信度 0.80
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Social isolation is commonly used to model social stress and is a known risk factor for depression, with impacts on hippocampal function and postnatal neurogenesis. However, most studies focus on social isolation in juvenile mice isolation during adolescence, …
europepmc
2026
置信度 0.80