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• A circadian biosignature in the labeled release data from Mars?
  crossref Hans P. A. Van Dongen, Joseph D. Miller, Gilbert V. Levin, Patricia A. Straat 2005-09-22T22:01:44Z 置信度 0.70
• MICROBIAL COLONIZATION AND BIOSIGNATURE PRESERVATION POTENTIAL IN ACIDIC GYPSUM DEPOSITS FROM SULFIDIC CAVES
  crossref Zoe Havlena, Heather V. Graham, Jennifer Stern, Angela Chung 等 2022-11-01T17:50:55Z 置信度 0.70
• Proxima Centauri b: A Strong Case for Including Cosmic-Ray-induced Chemistry in Atmospheric Biosignature Studies
  Abstract Due to its Earth-like minimum mass of 1.27 M E and its close proximity to our solar system, Proxima Centauri b is one of the most interesting exoplanets for habitability studies. Its host star, Proxima Centauri, is however a strongly flaring star, whi…
  crossref M. Scheucher, K. Herbst, V. Schmidt, J. L. Grenfell 等 2020-04-08T14:13:34Z 置信度 0.70
• RNA Transcriptional Biosignature Analysis for Identifying Febrile Infants With Serious Bacterial Infections in the Emergency Department
  crossref Prashant Mahajan, Nathan Kuppermann, Nicolas Suarez, Asuncion Mejias 等 2014-12-31T16:29:57Z 置信度 0.70
• Biofluorescent Worlds – II. Biological fluorescence induced by stellar UV flares, a new temporal biosignature
  ABSTRACT Our first targets in the search for signs of life are orbiting nearby M stars, such as the planets in the Proxima Centauri, Ross-128, LHS-1140, and TRAPPIST-1 systems. Future ground-based discoveries, and those from the TESS mission, will provide addi…
  crossref Jack T O'Malley-James, Lisa Kaltenegger 2019-07-15T15:10:19Z 置信度 0.70
• Using Passive Sensing to Isolate a Biosignature for Craving Among Individuals in Early Alcohol Use Disorder Recovery
  ABSTRACT Craving is one of the most robust proximal predictors of both treatment dropout and relapse during early recovery for alcohol use disorder (AUD). Craving can onset rapidly, and the ability to accurately detect or modulate cravings varies significantly…
  europepmc Sara Mei, Noah N. Emery, David Eddie 2026 置信度 0.80
• Interpretable Machine Learning Biosignature Detection From Ocean Worlds Analogue CO ₂ Isotopologue Data
  Abstract Future missions to icy ocean worlds (OW) such as Europa and Enceladus will evaluate the habitability and potential for biosignatures on these worlds. These missions will benefit from autonomous science and machine learning (ML) methods to process high…
  crossref Lily A. Clough, Victoria Da Poian, Jonathan D. Major, Lauren M. Seyler 等 2025-03-11T11:24:54Z 置信度 0.70
• Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells
  Gemifloxacin (GMF) is an orally administered broad-spectrum fluoroquinolone antimicrobial agent used to treat acute bacterial exacerbation of pneumonia and bronchitis. Although fluoroquinolone antibiotics have also been found to have anti-inflammatory and anti…
  crossref Jung-Yu Kan, Ya-Ling Hsu, Yen-Hsu Chen, Tun-Chieh Chen 等 2013-12-10T16:01:38Z 置信度 0.70
• Habitability and Biosignature Formation in Simulated Martian Aqueous Environments
  Water present on early Mars is often assumed to have been habitable. In this study, experiments were performed to investigate the habitability of well-defined putative martian fluids and to identify the accompanying potential formation of biosignatures. Simula…
  pubmed Michael C. Macey, Nisha K. Ramkissoon, Simone Cogliati, Mario Toubes-Rodrigo 等 2022-12-28T14:56:54Z 置信度 0.82
• Independent Review of the Community Report from the Biosignature Standards of Evidence Workshop
  crossref 2022-07-18T11:05:52Z 置信度 0.70
• Bacterial cellulose may provide the microbial-life biosignature in the rock records
  crossref I. Zaets, O. Podolich, O. Kukharenko, G. Reshetnyak 等 2014-01-10T21:31:11Z 置信度 0.70
• 484 MAPping impulsivity: Cortical architecture as a biosignature for relapse vulnerability in substance use disorders
  Objectives/Goals: One in 14 individuals have a substance use disorder (SUD). We suggest that a trait of poor impulse control, or high impulsivity, may predict relapse risk. We explore how changes in brain structure linked to decision-making and reward might dr…
  crossref Holly Chapman, Jonathan D. Hommel, Kathryn A. Cunningham, Gracie Vargas 等 2025-03-25T23:58:20Z 置信度 0.70
• BIOSIGNATURE PRESERVATION AIDED BY ORGANIC-CATION INTERACTIONS IN PROTEROZOIC TIDAL ENVIRONMENTS
  Abstract The preservation of organic biosignatures during the Proterozoic Eon required specific taphonomic windows that could entomb organic matter to preserve amorphous kerogen and even microbial body fossils before they could be extensively degraded. Some of…
  crossref KELSEY R. MOORE, THEODORE M. PRESENT, FRANK PAVIA, JOHN P. GROTZINGER 等 2022-09-15T17:08:40Z 置信度 0.70
• Organic Biosignature Degradation in Hydrothermal and Serpentinizing Environments: Implications for Life Detection on Icy Moons and Mars
  Evidence of liquid water is a primary indicator of habitability on the icy moons in our outer solar system as well as on terrestrial planets such as Mars. If liquid water-containing environments host life, some of its organic remains can be fossilized and pres…
  pubmed Jonathan S.W. Tan, Tara L. Salter, Jonathan S. Watson, J. Hunter Waite 等 2023 置信度 0.82
• Abundant Atmospheric Methane from Volcanism on Terrestrial Planets Is Unlikely and Strengthens the Case for Methane as a Biosignature
  Abstract The disequilibrium combination of abundant methane and carbon dioxide has been proposed as a promising exoplanet biosignature that is readily detectable with upcoming telescopes such as the James Webb Space Telescope. However, few studies have explore…
  crossref Nicholas Wogan, Joshua Krissansen-Totton, David C. Catling 2020-10-29T15:14:21Z 置信度 0.70
• The Role of N ₂ as a Geo-Biosignature for the Detection and Characterization of Earth-like Habitats
  crossref Helmut Lammer, Laurenz Sproß, John Lee Grenfell, Manuel Scherf 等 2019-07-17T16:18:14Z 置信度 0.70
• Resistance to depth inversion illusions: A biosignature of psychosis with potential utility for monitoring positive symptom emergence and remission in schizophrenia
  crossref Samantha I. Fradkin, Steven M. Silverstein 2022-03-26T18:18:58Z 置信度 0.70
• Identification of Mosaic Order Area of Geometric Triangular Chiral Hexagonal Complexes in Interphase with Morphology Biosignature Pattern in the Interior of Martian Nested Impact Craters
  crossref Jairo A. Diaz, Karen E. Paris 2014-03-28T00:03:53Z 置信度 0.70
• Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis
  Background COVID-19, caused by SARS-CoV-2 virus, is a global pandemic with high mortality and morbidity. Limited diagnostic methods hampered the infection control. Since the direct detection of virus mainly by RT-PCR may cause false-negative outcome, host resp…
  crossref Cheng Zhang, Yi-Gang Feng, Chiwing Tam, Ning Wang 等 2021-11-30T09:59:00Z 置信度 0.70
• Proof of Concept Testing of Low Temperature Brine Microbial Habitats for Subsurface Mars and Europa Habitat Viability Scenario Testing and Astrobiology Biosignature Instrument Development
  <div class="htmlview paragraph">Presented is a synopsis of ongoing research into the development of techniques and hardware required to produce useable quantities of astrobiology relevant biomass under controlled and repeatable laboratory conditions. Thi…
  crossref Sherwin Gormly, V. Dean Adams, Eric Marchand, Bailey Cannon 等 2010-08-05T16:46:10Z 置信度 0.70
• The persistence of a chlorophyll spectral biosignature from Martian evaporite and spring analogues under Mars-like conditions
  Abstract Spring and evaporite deposits are considered two of the most promising environments for past habitability on Mars and preservation of biosignatures. Manitoba, Canada hosts the East German Creek (EGC) hypersaline spring complex, and the post impact eva…
  crossref J. M. Stromberg, D. M. Applin, E. A. Cloutis, M. Rice 等 2013-12-18T04:07:42Z 置信度 0.70
• MA07.05 Lung Cancer With Spread of Tumor Through Air Spaces: Transcriptomic Biosignature of Primary Tumors and Expression Analysis Airway Tumor Clusters
  crossref W.S. Brandt, A. Mabry, S. Sankararaman, D. Dev 等 2025-10-24T14:56:46Z 置信度 0.70
• Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
  crossref Izelle Smuts, Francois H. van der Westhuizen, Roan Louw, Lodewyk J. Mienie 等 2012-09-01T21:32:39Z 置信度 0.70
• Planetary freedom and constructal drivers of Earth's architectures.
  europepmc 2026 置信度 0.80
• Νovel methylation biomarkers in liquid biopsy and classifying biosignatures for the clinical management of Breast Cancer
  europepmc 2025 置信度 0.80
• Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.
  europepmc 2026 置信度 0.80
• Regolith as a Refuge: Differential Survival of Bacteriophage Qβ in Mars-Analog Environments
  europepmc 2025 置信度 0.80
• NMR-based Urinary Biomarkers in Pediatric Primary Mitochondrial Disorders and Chronic Kidney Disease: Shared Mitochondrial Dysfunction, Diverging Biosignatures
  europepmc 2025 置信度 0.80
• Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections.
  europepmc 2025 置信度 0.80
• Low Frequency Oscillations in the Medial Orbitofrontal Cortex Mediate Widespread Hyperalgesia Across Pain Conditions
  europepmc 2025 置信度 0.80
• The gut-brain axis in depression: Are multi-omics showing the way?
  europepmc 2024 置信度 0.80
• Predictive biosignatures for hospitalization in patients with virologically confirmed COVID-19.
  europepmc 2025 置信度 0.80
• The search for life signatures on Mars by the Tianwen-3 Mars sample return mission.
  europepmc 2024 置信度 0.80
• NMR-based urinary biomarkers in pediatric primary mitochondrial disorders and chronic kidney disease: shared mitochondrial dysfunction, diverging biosignatures.
  europepmc 2026 置信度 0.80
• The clumped isotope signatures of multiple methanogenesis metabolisms
  europepmc 2024 置信度 0.80
• Biomarkers: The Key to Enhancing Deep Brain Stimulation Treatment for Psychiatric Conditions.
  europepmc 2024 置信度 0.80
• Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
  europepmc 2024 置信度 0.80
• Human life expectancy and season of birth in Taiwan: A retrospective cohort study.
  Abstract Prior research has indicated a correlation between the birth season and life expectancy; however, many of these studies did not sufficiently account for comorbidities. In this comprehensive investigation, we aimed to meticulously explore the associati…
  europepmc Tsutomu Nishimura, Eiji Nakatani, Mei-Chen Lin, Hiroyuki Yamauchi 等 2024 置信度 0.80
• Integrative proteome analysis of bone marrow interstitial fluid and serum reveals candidate signature for acute myeloid leukemia.
  europepmc 2024 置信度 0.80
• "Clues of Life" through Mineral Lattice Investigation in the Extreme Cold Conditions of Ladakh, India: An Astrobiological Perspective Using the Geyser Travertine Deposit of Puga Hot Spring
  europepmc 2024 置信度 0.80
• Assessment of methods for evaluating structural stability of cell envelope fragments in hypersaline brines as biosignatures of ancient microbial life.
  europepmc 2025 置信度 0.80
• New insights into metabolism dysregulation after TBI.
  europepmc 2024 置信度 0.80
• Comparing Protein Stability in Modern and Ancient Sabkha Environments: Implications for Molecular Remnants on Ancient Mars.
  europepmc 2025 置信度 0.80
• Extant life detection using label-free video microscopy in analog aquatic environments.
  europepmc 2025 置信度 0.80
• Secure Ileal Pouch-Anal Anastomosis for Histologic Indeterminate Colitis.
  europepmc 2025 置信度 0.80
• Discovery and Validation of Serum Metabolic Signature of Neonatal Sepsis
  europepmc 2024 置信度 0.80
• Insights From Omics in Lyme Disease.
  europepmc 2024 置信度 0.80
• Experimentally measured assembly indices are required to determine the threshold for life.
  europepmc 2024 置信度 0.80
• Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis.
  europepmc 2024 置信度 0.80
• Serum cytokine biosignatures for identification of tuberculosis among HIV-positive inpatients.
  europepmc 2024 置信度 0.80
• Insights from LC-MS-based cerebrospinal fluid metabolomics in tuberculous meningitis.
  europepmc 2026 置信度 0.80
• Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis.
  europepmc 2024 置信度 0.80
• Detecting life by behavior, the overlooked sensitivity of behavioral assays.
  europepmc 2024 置信度 0.80
• Energy-ordered resource stratification as an agnostic signature of life
  europepmc 2024 置信度 0.80
• The Clinical Utility of a 7-Gene Biosignature on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery: An Updated Analysis of the DCISionRT^® PREDICT Study.
  Abstract Background Breast-conserving surgery (BCS) followed by adjuvant radiotherapy (RT) is a standard treatment for ductal carcinoma in situ (DCIS). A low-risk patient subset that does not benefit from RT has not yet been clearly identified. The DCISionRT t…
  europepmc Chirag Shah, Pat Whitworth, Frank A. Vicini, Steven Narod 等 2024 置信度 0.80
• Biosignatures of in situ carbon cycling driven by physical isolation and sedimentary methanogenesis within the anoxic basin of perennially ice-covered Lake Untersee, Antarctica
  europepmc 2024 置信度 0.80
• Reply to 'Experimental measurement of assembly indices are required to determine the threshold for life'.
  europepmc 2024 置信度 0.80
• Psychotic Disorders and exosomes: An overview of current evidence and future directions.
  europepmc 2024 置信度 0.80
• Microbial metabolism in deep terrestrial subsurface communities - amino acids as biosignatures.
  The deep terrestrial subsurface (DTS) biosphere consists of a variety of distinct microbial taxa, mostly bacterial. The mechanisms by which microbes dynamically manage the uptake and concurrent utilization of nutrients within the DTS environments remain largel…
  europepmc 2026 置信度 0.80
• Integrated high performance microfluidic organic analysis instrument for planetary and space exploration.
  The exploration of our solar system to characterize the molecular organic inventory will enable the identification of potentially habitable regions and initiate the search for biosignatures of extraterrestrial life. However, it is challenging to perform the re…
  pubmed Butterworth AL, Golozar M, Estlack Z, McCauley J 等 2024 置信度 0.82
• On the salient limitations of the methods of assembly theory and their classification of molecular biosignatures.
  europepmc 2024 置信度 0.80
• A multi-omics-empowered framework for precision diagnosis and treatment of lysosomal diseases.
  europepmc 2025 置信度 0.80
• Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight
  europepmc 2024 置信度 0.80
• Hydrochemical and isotopic characteristics of water sources for biological activity across a massive evaporite basin on the Tibetan Plateau: Implications for aquatic environments on early Mars.
  Covered by vast eolian landforms, gravel deposits, and playas, the worldwide typical evaporite deposit land, Qaidam Basin, in northwestern China is analogous to early Mars when the aridification process had lasted for millions of years since the end of a wette…
  europepmc 2024 置信度 0.80
• Integrating biomarkers and artificial intelligence for precision diagnostics in cattle health and herd management: a review.
  europepmc 2026 置信度 0.80
• Combining metabolomics and machine learning to discover biomarkers for early-stage breast cancer diagnosis.
  europepmc 2024 置信度 0.80
• Integrated transcriptomic and machine learning analysis reveals novel diagnostic biomarkers for adolescent major depressive disorder.
  europepmc 2026 置信度 0.80
• [Study on mechanism of regulation of sex hormones in treatment of hyperprolactinemia-induced ovulatory disorder infertility with Bushen Culuan Formula].
  europepmc 2024 置信度 0.80
• Bioenergetics of iron snow fueling life on Europa.
  europepmc 2024 置信度 0.80
• Hydrogenotrophic Methanogenesis at 7-12 mbar by Methanosarcina barkeri under Simulated Martian Atmospheric Conditions
  europepmc 2024 置信度 0.80
• Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight
  europepmc 2024 置信度 0.80
• Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease.
  europepmc 2025 置信度 0.80
• Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease.
  europepmc 2024 置信度 0.80
• Special Issue: 'Advances in Space Biology'.
  europepmc 2024 置信度 0.80
• Discovery and validation of serum metabolic signature of neonatal sepsis
  europepmc 2024 置信度 0.80
• Arachidonic Acid Metabolism and HETEs-PGs Imbalance in <i>L. infantum</i> Infection: Implications for Visceral Leishmaniasis Progression.
  europepmc 2025 置信度 0.80
• Innate biosignature of treatment failure in human cutaneous leishmaniasis.
  europepmc María Adelaida Gómez, Ashton Trey Belew, Deninson Alejandro Vargas, Lina Giraldo-Parra 等 2025 置信度 0.80
• Resolution and quantification of carbohydrates by enantioselective comprehensive two-dimensional gas chromatography.
  europepmc 2024 置信度 0.80
• BAMBI: Integrative <i>b</i> iostatistical and <i>a</i> rtificial-intelligence <i>m</i> odels discover coding and non-coding RNA genes as <i>bi</i> omarkers
  europepmc 2024 置信度 0.80
• Sampling Mars: Geologic context and preliminary characterization of samples collected by the NASA Mars 2020 Perseverance Rover Mission.
  europepmc 2025 置信度 0.80
• Potential hematological biosignatures as screening tools for tuberculosis co- infection among people living with HIV
  europepmc 2024 置信度 0.80
• Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success.
  europepmc 2024 置信度 0.80
• Measuring Molecular Complexity.
  europepmc 2024 置信度 0.80
• Adult type I Gaucher disease with splenectomy caused by a compound heterozygous GBA1 mutation in a Chinese patient: a case report.
  europepmc 2024 置信度 0.80
• Microbial respiration - a biomineral perspective.
  europepmc 2025 置信度 0.80
• Hsa-miRNA-16-5p Of Urinary Exosomes A Reliable Biosignature Effective For Prostate Cancer Screening.
  europepmc Wen-Hui Weng, Yueh-Er Chiou, Wen-Zhen Zeng, Ming-Hui Chen 等 2025 置信度 0.80
• Diagnostic accuracy of MMBV in predicting bacterial infection in febrile children: a systematic review and meta-analysis.
  europepmc 2026 置信度 0.80
• A robust, agnostic molecular biosignature based on machine learning.
  The search for definitive biosignatures—unambiguous markers of past or present life—is a central goal of paleobiology and astrobiology. We used pyrolysis–gas chromatography coupled to mass spectrometry to analyze chemically disparate samples, including living …
  pubmed H. James Cleaves, Grethe Hystad, Anirudh Prabhu, Michael L. Wong 等 2023 置信度 0.82
• Analysis of the expression level and predictive value of CLEC16A|miR-654-5p|RARA regulatory axis in the peripheral blood of patients with ischemic stroke based on biosignature analysis.
  Introduction Ischemic stroke (IS) is a cerebrovascular disease that can be disabling and fatal, and there are limitations in the clinical treatment and prognosis of IS. It has been reported that changes in the expression profile of circRNAs have been found dur…
  europepmc Jiang-jie Hao, Yuan Liu, Jun-hua Lu, Ying Zhao 等 2024 置信度 0.80
• The Tubotomaculum Enigma and the Rise of Benthic Life During the Opening of the Western Mediterranean Basin.
  europepmc 2025 置信度 0.80
• A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe.
  europepmc 2025 置信度 0.80
• Nonconceptus Mechanisms of Prenatal Alcohol Exposure That Disrupt Embryo-Fetal Development: An Integrative View.
  europepmc 2025 置信度 0.80
• Cognition falters at ~4 Hz in Parkinson's disease.
  europepmc 2024 置信度 0.80
• Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous coronary intervention: a prospective longitudinal cohort study.
  europepmc 2025 置信度 0.80
• EEG and ERP biosignatures of mild cognitive impairment for longitudinal monitoring of early cognitive decline in Alzheimer's disease.
  europepmc 2024 置信度 0.80
• Sphingolipid metabolism and hematologic disorders: current understanding and future directions.
  europepmc 2026 置信度 0.80
• Evolutionary features in a minimal physical system: Diversity, selection, growth, inheritance, and adaptation.
  europepmc 2025 置信度 0.80
• Neuroinflammation and insulin resistance in major depression and bipolar disorder: Implications for clinical trials evaluating immunometabolic targeted therapies.
  europepmc 2026 置信度 0.80
• Serum Lipidomic Analysis of T2DM Patients: A Potential Biomarker Study.
  europepmc 2025 置信度 0.80
• Aluminous phyllosilicates promote exceptional nanoscale preservation of biogeochemical heterogeneities in Archaean siliciclastic microbial mats.
  europepmc 2025 置信度 0.80