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• Rewriting Life; The New Age Challenges of Biotechnology
  Abstract Biotechnology is at a tipping point with the advent of gene editing, synthetic biology, artificial intelligence for drug discovery and personalised medicine. This article critically analyses the complex challenges accompanying these advances — regulat…
  datacite Kadam, Shoba 2026 置信度 0.66 Keywords: Biotechnology, CRISPR, Gene Editing, Bioethics, Regulatory Frameworks, Synthetic Biology, Personalised Medicine, Biosecurity, Equitable Access
• Rewriting Life; The New Age Challenges of Biotechnology
  Abstract Biotechnology is at a tipping point with the advent of gene editing, synthetic biology, artificial intelligence for drug discovery and personalised medicine. This article critically analyses the complex challenges accompanying these advances — regulat…
  datacite Kadam, Shoba 2026 置信度 0.66 Keywords: Biotechnology, CRISPR, Gene Editing, Bioethics, Regulatory Frameworks, Synthetic Biology, Personalised Medicine, Biosecurity, Equitable Access
• Integrative Perspectives on Genetic Engineering in Agriculture, Food Biotechnology, and Human Development
  The rapidly developing field of biotechnology and genetic engineering uses living things, cells and biological systems to create products and technologies that enhance both human life and the environment. A crucial branch of biotechnology, genetic engineering …
  datacite Dr. K. Nalini, Dr. T. Sivakumar, R. Yogakani 2026 置信度 0.66 Food technology, CRISPR, Agriculture, Health, Ethics
• Integrative Perspectives on Genetic Engineering in Agriculture, Food Biotechnology, and Human Development
  The rapidly developing field of biotechnology and genetic engineering uses living things, cells and biological systems to create products and technologies that enhance both human life and the environment. A crucial branch of biotechnology, genetic engineering …
  datacite Dr. K. Nalini, Dr. T. Sivakumar, R. Yogakani 2026 置信度 0.66 Food technology, CRISPR, Agriculture, Health, Ethics
• A Review on Advancing Stem Cell Therapy and Tissue Engineering to Regenerate Damaged Tissues and Organs
  In the field of regenerative medicine, developing stem cell therapy and tissue engineering has become a game-changing strategy that holds promise for replacing and repairing damaged organs and tissues. Innovative biological interventions are required since tra…
  datacite Patil, Pravin, Kale, Vivek, Ware, Tanaya, Karande, Amruta 等 2026 置信度 0.66 biological sciencespharmacological sciencesstem therapyBiomedical Engineering
• A Review on Advancing Stem Cell Therapy and Tissue Engineering to Regenerate Damaged Tissues and Organs
  In the field of regenerative medicine, developing stem cell therapy and tissue engineering has become a game-changing strategy that holds promise for replacing and repairing damaged organs and tissues. Innovative biological interventions are required since tra…
  datacite Patil, Pravin, Kale, Vivek, Ware, Tanaya, Karande, Amruta 等 2026 置信度 0.66 biological sciencespharmacological sciencesstem therapyBiomedical Engineering
• SNAI1 target genes in myoblasts
  SNAI proteins are zinc finger transcription factors that act as transcriptional repressors through a conserved domain (SNAG domain) located in the N-terminus of the protein. These factors bind to a palindromic sequence of the E-box group (CANNTG) in the regula…
  datacite Elia, Ines 2021 置信度 0.66
• Building a platform for flexible and scalable testing of genetic editors
  Cell-free systems allow to perform in-vitro transcription-translation reactions without requiring living organisms, revolutionising scientific research over the last decade. This allows to easily synthesise a variety of molecular components for genetic editing…
  datacite Teresa Petrucci 2021 置信度 0.66
• Emerging Therapies for Inborn Errors of Metabolism: Enzyme Replacement, Gene Therapy, Genome Editing
  Abstract Inborn Errors of Metabolism (IEMs) are a heterogeneous collection of inherited genetic illnesses resulting from abnormalities in enzymes, transport proteins, or cofactors involved in important metabolic pathways. These deficiencies interfere with norm…
  datacite Nebedum Emilia Nwakaego, Mbah Gertrude, Deborah Chinonso, Osimiri Eugene Chika 等 2026 置信度 0.66 Inborn Abnormalities of Metabolism; Enzyme Replacement Therapy; Gene Therapy; Genome Editing; CRISPR-Cas9 Lysosomal Storage Problems; Precision Medicine
• Emerging Therapies for Inborn Errors of Metabolism: Enzyme Replacement, Gene Therapy, Genome Editing
  Abstract Inborn Errors of Metabolism (IEMs) are a heterogeneous collection of inherited genetic illnesses resulting from abnormalities in enzymes, transport proteins, or cofactors involved in important metabolic pathways. These deficiencies interfere with norm…
  datacite Nebedum Emilia Nwakaego, Mbah Gertrude, Deborah Chinonso, Osimiri Eugene Chika 等 2026 置信度 0.66 Inborn Abnormalities of Metabolism; Enzyme Replacement Therapy; Gene Therapy; Genome Editing; CRISPR-Cas9 Lysosomal Storage Problems; Precision Medicine
• WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
  Hereditary diseases are genetic disorders that are passed from one generation to another through inherited genetic material. These disorders may result from mutations in a single gene, abnormalities in chromosomes, defects in mitochondrial DNA, or interactions…
  datacite Arpita Chauhan, Umesh Parekh*, Manoj Goyal 2026 置信度 0.66
• WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
  Hereditary diseases are genetic disorders that are passed from one generation to another through inherited genetic material. These disorders may result from mutations in a single gene, abnormalities in chromosomes, defects in mitochondrial DNA, or interactions…
  datacite Arpita Chauhan, Umesh Parekh*, Manoj Goyal 2026 置信度 0.66
• PHARMACOGENOMICS IN RARE DISEASE MANAGEMENT: A Comprehensive Review of Principles, Applications, and Emerging Frontiers
  Background: Rare diseases, defined in most regulatory jurisdictions as conditions affecting fewer than 1 in 2,000 individuals, collectively impose a profound global health burden, touching an estimated 300 to 400 million people worldwide. Because individual ra…
  datacite Anoop Kumar*, Aman Kumar, Niraj Gupta, Shivpratap Singh, Ashvani Kumar 2026 置信度 0.66 pharmacogenomics, rare diseases, orphan drugs, precision medicine, genetic variation, drug metabolism.
• PHARMACOGENOMICS IN RARE DISEASE MANAGEMENT: A Comprehensive Review of Principles, Applications, and Emerging Frontiers
  Background: Rare diseases, defined in most regulatory jurisdictions as conditions affecting fewer than 1 in 2,000 individuals, collectively impose a profound global health burden, touching an estimated 300 to 400 million people worldwide. Because individual ra…
  datacite Anoop Kumar*, Aman Kumar, Niraj Gupta, Shivpratap Singh, Ashvani Kumar 2026 置信度 0.66 pharmacogenomics, rare diseases, orphan drugs, precision medicine, genetic variation, drug metabolism.
• A Programmable Genome: A Narrative Review of CRISPR-Cas9 from Bacterial Immunity to Base and Prime Editing
  CRISPR-Cas9 transformed genome editing from an artisanal procedure into programmable technology. This article presents a narrative review of the field's canonical line: Ishino and colleagues' 1987 observation of clustered repeats, Mojica and colleagues' identi…
  datacite Revista, Zen, BIOLOGY, 10 2026 置信度 0.66 CRISPRCas9genome editinggene therapybase editing
• A Programmable Genome: A Narrative Review of CRISPR-Cas9 from Bacterial Immunity to Base and Prime Editing
  CRISPR-Cas9 transformed genome editing from an artisanal procedure into programmable technology. This article presents a narrative review of the field's canonical line: Ishino and colleagues' 1987 observation of clustered repeats, Mojica and colleagues' identi…
  datacite Revista, Zen, BIOLOGY, 10 2026 置信度 0.66 CRISPRCas9genome editinggene therapybase editing
• CRISPR-Cas9 gene editing: a new promising treatment for Rett syndrome
  Rett syndrome (RTT) is a neurodevelopmental disorder affecting the central nervous system and is one of the most common causes of intellectual disability in girls, resulting in severe cognitive and physical disabilities. Mutations in MECP2 and FOXG1 genes caus…
  datacite Susanna Croci 2020 置信度 0.66
• Development of a multi - Targeted Combinatorial Nano therapeutic Cascade Using CRISPR Intrabodies ,and BDNF Growth Factors For Huntington 's Disease Neuro Regeneration "
  वैज्ञानिक अनुसंधान प्रस्ताव (Research Article Proposal)शीर्षक (Title): हंटिंगटन रोग के न्यूरो-रीजनरेशन के लिए मल्टी-टार्गेटेड जीन-एंटीबॉडी नैनोथेराप्यूटिक कास्केड का कार्यान्वयनआविष्कारक का नाम (Inventor Name): बंटी कुमावत (Banti Kumawat)वर्ष (Year): 2026🔬 1.…
  datacite Kumawat, Banti kumawat 2026 置信度 0.66
• Development of a multi - Targeted Combinatorial Nano therapeutic Cascade Using CRISPR Intrabodies ,and BDNF Growth Factors For Huntington 's Disease Neuro Regeneration "
  वैज्ञानिक अनुसंधान प्रस्ताव (Research Article Proposal)शीर्षक (Title): हंटिंगटन रोग के न्यूरो-रीजनरेशन के लिए मल्टी-टार्गेटेड जीन-एंटीबॉडी नैनोथेराप्यूटिक कास्केड का कार्यान्वयनआविष्कारक का नाम (Inventor Name): बंटी कुमावत (Banti Kumawat)वर्ष (Year): 2026🔬 1.…
  datacite Kumawat, Banti kumawat 2026 置信度 0.66
• Recent Advances in Joubert Syndrome: Genetic Insights, Clinical Management, and Emerging Therapeutic Strategies
  Joubert syndrome (JS) is a rare, genetically heterogeneous autosomal recessive ciliopathy characterized by the pathognomonic molar tooth sign (MTS) on brain magnetic resonance imaging, resulting from cerebellar vermis hypoplasia or aplasia and abnormal superio…
  datacite Damera Neha, Syeda Nishat Fathima 2026 置信度 0.66
• Recent Advances in Joubert Syndrome: Genetic Insights, Clinical Management, and Emerging Therapeutic Strategies
  Joubert syndrome (JS) is a rare, genetically heterogeneous autosomal recessive ciliopathy characterized by the pathognomonic molar tooth sign (MTS) on brain magnetic resonance imaging, resulting from cerebellar vermis hypoplasia or aplasia and abnormal superio…
  datacite Damera Neha, Syeda Nishat Fathima 2026 置信度 0.66
• CRISPR-BASED GENE EDITING & THERAPEUTIC APPLICATIONS
  datacite Reddy, Pushpa 2026 置信度 0.66
• CRISPR-BASED GENE EDITING & THERAPEUTIC APPLICATIONS
  datacite Reddy, Pushpa 2026 置信度 0.66
• THALASSEMIA AS A GENETIC DISORDER
  Description Thalassemia as a Genetic Disorder: From β-Globin Mutation to Precision Prevention and Gene-Based Therapy is an evidence-informed international review that provides a comprehensive overview of thalassemia as an inherited genetic disorder, with parti…
  datacite Qaiser, Dr. Zeeshan 2026 置信度 0.66 Thalassemiahemoglobin disorders,β-thalassemia,β-globin gene,HBB gene,
• THALASSEMIA AS A GENETIC DISORDER
  Description Thalassemia as a Genetic Disorder: From β-Globin Mutation to Precision Prevention and Gene-Based Therapy is an evidence-informed international review that provides a comprehensive overview of thalassemia as an inherited genetic disorder, with parti…
  datacite Qaiser, Dr. Zeeshan 2026 置信度 0.66 Thalassemiahemoglobin disorders,β-thalassemia,β-globin gene,HBB gene,
• Bacterial Memory to Genome Surgery: A Narrative Review of the CRISPR Systems, from Repeated Sequences to Prime Editing
  CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing---Cas9's programmable double-strand cuts…
  datacite Revista, Zen, BIOLOGY, 10 2026 置信度 0.66 CRISPRCas9Cas12Cas13prime editing
• Bacterial Memory to Genome Surgery: A Narrative Review of the CRISPR Systems, from Repeated Sequences to Prime Editing
  CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing---Cas9's programmable double-strand cuts…
  datacite Revista, Zen, BIOLOGY, 10 2026 置信度 0.66 CRISPRCas9Cas12Cas13prime editing
• Development and Application of Adenine Base Editors for Precision Gene Therapy
  CRISPR-Cas technology has revolutionized functional genomics, and gene therapy by enabling precise and programmable manipulation of the genome. Early CRISPR-Cas nucleases relied on the generation of double-strand breaks (DSBs) to disrupt genes or introduce exo…
  datacite Gao, Jenny 2026 置信度 0.66
• GENE THERAPY: EMERGING TRENDS AND ITS TRANSFORMATIVE ROLE IN MODERN MEDICINE
  Gene therapy has rapidly evolved as an innovative therapeutic strategy aimed at modifying genetic material to treat or prevent diseases at their molecular origin. Unlike conventional pharmacotherapy, which primarily alleviates symptoms, gene therapy focuses on…
  datacite Prof. Ashwini Shrikrushna Taware* 2026 置信度 0.66
• GENE THERAPY: EMERGING TRENDS AND ITS TRANSFORMATIVE ROLE IN MODERN MEDICINE
  Gene therapy has rapidly evolved as an innovative therapeutic strategy aimed at modifying genetic material to treat or prevent diseases at their molecular origin. Unlike conventional pharmacotherapy, which primarily alleviates symptoms, gene therapy focuses on…
  datacite Prof. Ashwini Shrikrushna Taware* 2026 置信度 0.66
• Core Concepts of Biochemistry for Modern Medical Curriculum: Bridging Molecular Science to Clinical Applications and Drug Development
  This extensive whitepaper provides a rigorous framework for embedding core biochemical concepts into contemporary medical curricula, emphasizing the translation of molecular science into clinical applications and pharmaceutical development. The document begins…
  datacite biochemical science 2026 置信度 0.66 biochemistrymedical educationdrug developmentmetabolismprotein folding
• Core Concepts of Biochemistry for Modern Medical Curriculum: Bridging Molecular Science to Clinical Applications and Drug Development
  This extensive whitepaper provides a rigorous framework for embedding core biochemical concepts into contemporary medical curricula, emphasizing the translation of molecular science into clinical applications and pharmaceutical development. The document begins…
  datacite biochemical science 2026 置信度 0.66 biochemistrymedical educationdrug developmentmetabolismprotein folding
• Revolutionizing the Genome: Ethical Innovations, Equitable Policies, and a Mathematical Framework for Affordable Regenerative Medicine.
  This research presents an interdisciplinary exploration of the ethical, economic, and policy challenges shaping the future of genomics and regenerative medicine. Focusing on transformative technologies such as CRISPR gene editing and synthetic embryo models, t…
  datacite David, Peter Oloche 2026 置信度 0.66 GenomicsCRISPRRegenerative MedicineBioethicsBioethics
• Revolutionizing the Genome: Ethical Innovations, Equitable Policies, and a Mathematical Framework for Affordable Regenerative Medicine.
  This research presents an interdisciplinary exploration of the ethical, economic, and policy challenges shaping the future of genomics and regenerative medicine. Focusing on transformative technologies such as CRISPR gene editing and synthetic embryo models, t…
  datacite David, Peter Oloche 2026 置信度 0.66 GenomicsCRISPRRegenerative MedicineBioethicsBioethics
• CRISPR-CAS9 GENE EDITING IN PHARMACEUTICAL DEVELOPMENT FOR PRECISION MEDICINE
  This research primarily examines the application of CRISPR-Cas9 gene editing technology in the development of precision medicine, emphasizing its potential to revolutionize the treatment of genetic illnesses. CRISPR-Cas9 enables the exact alteration of DNA seq…
  datacite International Journal of BioTech, Pharmaceutical, Engineering, Management and Sciences 2026 置信度 0.66 CRISPR-Cas9Gene EditingPrecision MedicinePharmaceutical DevelopmentPersonalized Therapy
• CRISPR-CAS9 GENE EDITING IN PHARMACEUTICAL DEVELOPMENT FOR PRECISION MEDICINE
  This research primarily examines the application of CRISPR-Cas9 gene editing technology in the development of precision medicine, emphasizing its potential to revolutionize the treatment of genetic illnesses. CRISPR-Cas9 enables the exact alteration of DNA seq…
  datacite International Journal of BioTech, Pharmaceutical, Engineering, Management and Sciences 2026 置信度 0.66 CRISPR-Cas9Gene EditingPrecision MedicinePharmaceutical DevelopmentPersonalized Therapy
• Plant Biosystems Design: Foundational Principles, Methodologies, and Applications for Advanced Research
  Plant biosystems design represents a fundamental paradigm shift in agricultural and biological sciences, moving away from empirical trial-and-error breeding toward the rational, predictive engineering of plant systems. This extensive guide delineates the found…
  datacite plant science technology 2026 置信度 0.66 Plant Biosystems DesignMechanistic ModelingGraph TheoryEvolutionary DynamicsGenome Editing
• Plant Biosystems Design: Foundational Principles, Methodologies, and Applications for Advanced Research
  Plant biosystems design represents a fundamental paradigm shift in agricultural and biological sciences, moving away from empirical trial-and-error breeding toward the rational, predictive engineering of plant systems. This extensive guide delineates the found…
  datacite plant science technology 2026 置信度 0.66 Plant Biosystems DesignMechanistic ModelingGraph TheoryEvolutionary DynamicsGenome Editing
• Regulatory mechanisms for COL5A1 expression in the human cornea in health and disease
  Keratoconus is a complex corneal condition that is characterised by progressive corneal thinning and significant irregular astigmatism and eventual visual loss. The aetiology of keratoconus is not known although genetics is likely to play a large role in indiv…
  datacite Mustafa, Mohammad Zuhair 2022 置信度 0.66 keratoconusCOL5A1collagencorneal thicknesscFos protein
• Nanotechnology-Driven Gene Editing: Emerging CRISPR-Cas9 Nanocomposite Systems in Oncology
  datacite Pakistan Journal of Medical & Cardiological Review 2026 置信度 0.66
• Nanotechnology-Driven Gene Editing: Emerging CRISPR-Cas9 Nanocomposite Systems in Oncology
  datacite Pakistan Journal of Medical & Cardiological Review 2026 置信度 0.66
• Ownership Doesn't Means Authorship in Biology - The Secondary Signature of Immune System - The Architecture of Secondary Stage - Sam Coole 2026 ©️
  Reassigning Authorship: How the "Secondary Signature of the Immune System" Resolves Virology's Greatest Frustrations‌ currently observed by Scientific Community Authorship vs Ownership in Virology Host-Pathogen Authority For decades, the global virology resear…
  datacite COOLE, SAM, Coole, Sam 2026 置信度 0.66
• Ownership Doesn't Means Authorship in Biology - The Secondary Signature of Immune System - The Architecture of Secondary Stage - Sam Coole 2026 ©️
  Reassigning Authorship: How the "Secondary Signature of the Immune System" Resolves Virology's Greatest Frustrations‌ currently observed by Scientific Community Authorship vs Ownership in Virology Host-Pathogen Authority For decades, the global virology resear…
  datacite COOLE, SAM, Coole, Sam 2026 置信度 0.66
• THE INEVITABLE ELECTRIC TECHNOCRACY - Why Traditional Governance No Longer Works
  This paper develops a comprehensive socio-legal and techno-economic framework for the transition from the classical system of sovereign nation-states to a unified global order grounded in the doctrine of the Juridical Singularity and operationalized through El…
  datacite Durkac, Yalcin Veddat 2026 置信度 0.66 Artificial IntelligenceSuperintelligenceGovernmentGovernanceUtopias
• THE INEVITABLE ELECTRIC TECHNOCRACY - Why Traditional Governance No Longer Works
  This paper develops a comprehensive socio-legal and techno-economic framework for the transition from the classical system of sovereign nation-states to a unified global order grounded in the doctrine of the Juridical Singularity and operationalized through El…
  datacite Durkac, Yalcin Veddat 2026 置信度 0.66 Artificial IntelligenceSuperintelligenceGovernmentGovernanceUtopias
• A World-First Discovery of Energy Modulation Theory (EMT): Computational Companion and Scale-Free Implications Across Scales (Version V3)
  Author’s Note: Declaration and Disclaimer This manuscript is a hypothesis-generating, speculative, and preliminary research work spanning multiple scientific disciplines. The core ideas are solely those of the author. The whole content of this manuscript was g…
  datacite ALAM, DR SEIKH JAHANGIR 2026 置信度 0.66 Energy Modulation Theory, EMT, active matter, dissipative structures, nonlinear modulation, history dependence, stochastic differential equations, scale-free systems, persistent inequality, computational companion
• Hutchinson Gilford Syndrome - Literature Review
  Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare, progressive genetic disorder characterized by accelerated aging in children due to mutations in the LMNA gene, resulting in the accumulation of the abnormal protein progerin. Although affected children app…
  datacite O. Rubina Sajjath*1,3, P. Neelesh1,3, M. Lakshmanan1,3, M. Poovarasan1,3, R. Sivasakthi2,3 2026 置信度 0.66 Hutchinson–Gilford Progeria Syndrome (HGPS); Progerin; Premature aging; Lamin A; Rare genetic disorder.
• Hutchinson Gilford Syndrome - Literature Review
  Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare, progressive genetic disorder characterized by accelerated aging in children due to mutations in the LMNA gene, resulting in the accumulation of the abnormal protein progerin. Although affected children app…
  datacite O. Rubina Sajjath*1,3, P. Neelesh1,3, M. Lakshmanan1,3, M. Poovarasan1,3, R. Sivasakthi2,3 2026 置信度 0.66 Hutchinson–Gilford Progeria Syndrome (HGPS); Progerin; Premature aging; Lamin A; Rare genetic disorder.
• From Bacterial Immunity to Biotech Revolution: The Comprehensive History and Discovery of CRISPR Technology
  This article provides a comprehensive overview of CRISPR technology, tracing its history from the 1987 discovery of unusual bacterial DNA repeats to its establishment as a programmable gene-editing tool. The core mechanism involves the Cas9 nuclease, guided by…
  datacite gene editing science 2026 置信度 0.66 CRISPRCas9gene editinggenome engineeringbacterial immunity
• From Bacterial Immunity to Biotech Revolution: The Comprehensive History and Discovery of CRISPR Technology
  This article provides a comprehensive overview of CRISPR technology, tracing its history from the 1987 discovery of unusual bacterial DNA repeats to its establishment as a programmable gene-editing tool. The core mechanism involves the Cas9 nuclease, guided by…
  datacite gene editing science 2026 置信度 0.66 CRISPRCas9gene editinggenome engineeringbacterial immunity
• A Scretching-Framework Recast of miRNA Targeting and Extranuclear Genome Quantitation
  This revised paper integrates the referenced miRNA-processing source, the Pur/Pyr DNA-RNA asymmetry paper, the JDCS bridge paper, the Maxwell–Scretching and SQC 260 nm closure papers, and the comparative mtDNA–satDNA–ChlorDNA–kDNA text into a single formatted …
  datacite Scretching, Daniel 2026 置信度 0.66
• A Scretching-Framework Recast of miRNA Targeting and Extranuclear Genome Quantitation
  This revised paper integrates the referenced miRNA-processing source, the Pur/Pyr DNA-RNA asymmetry paper, the JDCS bridge paper, the Maxwell–Scretching and SQC 260 nm closure papers, and the comparative mtDNA–satDNA–ChlorDNA–kDNA text into a single formatted …
  datacite Scretching, Daniel 2026 置信度 0.66
• Harnessing Green Genes for Resilient and Sustainable Agriculture
  Abstract Climate change poses severe challenges to modern agriculture, including heat waves, droughts, erratic rainfall and pest infestations that threaten food security. Farmers must produce more food with fewer resources while protecting ecosystems, demandin…
  datacite Vandna Kushwaha1, Lokesh Kumar Gangwar1* Shambhoo Prasad2, Hitesh Kumar1 , Vaibhav Kumar V. Shakhre3 ,Shiv Kumar Singh1 2026 置信度 0.66
• Harnessing Green Genes for Resilient and Sustainable Agriculture
  Abstract Climate change poses severe challenges to modern agriculture, including heat waves, droughts, erratic rainfall and pest infestations that threaten food security. Farmers must produce more food with fewer resources while protecting ecosystems, demandin…
  datacite Vandna Kushwaha1, Lokesh Kumar Gangwar1* Shambhoo Prasad2, Hitesh Kumar1 , Vaibhav Kumar V. Shakhre3 ,Shiv Kumar Singh1 2026 置信度 0.66
• Impact of extracellular vesicles on microglia functions during brain tumour initiation stages
  Glioblastomas represent the most malignant and rapidly progressing type of primary brain tumours. Within the tumour microenvironment, a significant portion of the tumour mass is composed of macrophages and microglia, which have been shown to support tumour dev…
  datacite Kiyga, Ezgi 2025 置信度 0.66 Extracellular vesicles (EVs)MicrogliaGlioblastomaTumour-initiating cellsZebrafish
• Training school on Homology-directed repair and Adeno-associated virus based delivery technologies report
  The GenE-HumDi Training School held in Trondheim (Norway) on the 24-26 June 2026, provided an overview of Homology-Directed Repair (HDR), CRISPR-based genome editing, and adeno-associated virus (AAV)-mediated gene delivery, with a strong emphasis on their appl…
  datacite Hejlesen, Rasmus, Isabel Ojeda Pérez, Bilbao-Arribas, Martin, Bahsi, Pınar 等 2026 置信度 0.66 Gene therapyGene Editing/methodsGene EditingGene Editing/trends
• Training school on Homology-directed repair and Adeno-associated virus based delivery technologies report
  The GenE-HumDi Training School held in Trondheim (Norway) on the 24-26 June 2026, provided an overview of Homology-Directed Repair (HDR), CRISPR-based genome editing, and adeno-associated virus (AAV)-mediated gene delivery, with a strong emphasis on their appl…
  datacite Hejlesen, Rasmus, Isabel Ojeda Pérez, Bilbao-Arribas, Martin, Bahsi, Pınar 等 2026 置信度 0.66 Gene therapyGene Editing/methodsGene EditingGene Editing/trends
• Bioengineering and Characterization of an Oncolytic Vaccinia Virus for Tumor Localized Lentivirus Production
  Oncolytic viruses (OVs) are multi-mechanistic, tumor-selective therapeutics that lyse cancer cells while stimulating anti-tumor immunity. However, one limitation of OVs as monotherapies is their inability to infect and eliminate every tumor cell. Since infecte…
  datacite Dave, Jaahnavi 2026 置信度 0.66 Oncolytic virusCancer immunotherapyGene therapyLentivirusRetroviral particles
• Study: AI7KE+ – A non-limited Artificial Intelligence as a system compatible with Natural Intelligence (NI) from an evolutionary ethics perspective
  A world model of Holistic Information Theory (GIT) with i = E, Dimension 0, Super-nothing and the seven languages of the laws of nature – with interdisciplinary follow-up studies (Physics · Medicine · Genetics · Biology · Sociology) Author: Dieter LiedtkeYear:…
  datacite Dieter Liedtke 2026 置信度 0.66
• Study: AI7KE+ – A non-limited Artificial Intelligence as a system compatible with Natural Intelligence (NI) from an evolutionary ethics perspective
  A world model of Holistic Information Theory (GIT) with i = E, Dimension 0, Super-nothing and the seven languages of the laws of nature – with interdisciplinary follow-up studies (Physics · Medicine · Genetics · Biology · Sociology) Author: Dieter LiedtkeYear:…
  datacite Liedtke, Dieter Walter 2026 置信度 0.66
• Study: AI7KE+ – A non-limited Artificial Intelligence as a system compatible with Natural Intelligence (NI) from an evolutionary ethics perspective
  A world model of Holistic Information Theory (GIT) with i = E, Dimension 0, Super-nothing and the seven languages of the laws of nature – with interdisciplinary follow-up studies (Physics · Medicine · Genetics · Biology · Sociology) Author: Dieter LiedtkeYear:…
  datacite Liedtke, Dieter Walter 2026 置信度 0.66
• Advanced mRNA and Gene Therapies: Emerging Technologies, Clinical Applications and Future Perspectives
  Abstract: The field of medicine is changing because of mRNA and gene therapy. These therapies are different because they treat diseases at the molecular level. This part of the book talks about the biology and technology of mRNA therapeutics and gene therapy, …
  datacite Nibedita Roy, Dhruba Jyoti Bora, Neha Gogoi, Lipika Khataniar 等 2026 置信度 0.66
• Advanced mRNA and Gene Therapies: Emerging Technologies, Clinical Applications and Future Perspectives
  Abstract: The field of medicine is changing because of mRNA and gene therapy. These therapies are different because they treat diseases at the molecular level. This part of the book talks about the biology and technology of mRNA therapeutics and gene therapy, …
  datacite Nibedita Roy, Dhruba Jyoti Bora, Neha Gogoi, Lipika Khataniar 等 2026 置信度 0.66
• Technical Note: Cybernetic Hematopoiesis and the Wave-Native Eradication of Sickle Cell Disease
  This technical note (Version 3.0) formalizes a wave‑native pharmacological architecture for in vivo eradication of Sickle Cell Disease (SCD) without myeloablative conditioning, reframing SCD as a genetic software fault rather than a hardware failure. The work …
  datacite Feeney, Don 2026 置信度 0.66 Cybernetic HematopoiesisWave‑Native PharmacologyFrequency‑Encoded Elastic Network (FEEN)Bistable Zwitterionic PolymersDuffing Oscillator Targeting
• Technical Note: Cybernetic Hematopoiesis and the Wave-Native Eradication of Sickle Cell Disease
  This technical note (Version 3.0) formalizes a wave‑native pharmacological architecture for in vivo eradication of Sickle Cell Disease (SCD) without myeloablative conditioning, reframing SCD as a genetic software fault rather than a hardware failure. The work …
  datacite Feeney, Don 2026 置信度 0.66 Cybernetic HematopoiesisWave‑Native PharmacologyFrequency‑Encoded Elastic Network (FEEN)Bistable Zwitterionic PolymersDuffing Oscillator Targeting
• Technical Note: Cybernetic Hematopoiesis and the Wave-Native Eradication of Sickle Cell Disease
  This work presents a theoretical cybernetic framework for the in vivo correction of Sickle Cell Disease, transitioning pharmacology from passive chemistry to active mechanical logic. This architecture establishes: Topological Targeting: Modeling the skeleton a…
  datacite Feeney, Don 2026 置信度 0.66 Cybernetic HematopoiesisWave‑Native PharmacologyFrequency‑Encoded Elastic Network (FEEN)Bistable Zwitterionic PolymersDuffing Oscillator Targeting
• PREreview of "Rare Genetic Traits in Plants and Animals and How Their Preservation Can Help Humanity"
  This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/20048014. Short summary of the research and contribution to the field This review discusses the importance of rare geneti…
  datacite Ananddeep Patel 2026 置信度 0.66 Requested PREreview
• PREreview of "Rare Genetic Traits in Plants and Animals and How Their Preservation Can Help Humanity"
  This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/20048014. Short summary of the research and contribution to the field This review discusses the importance of rare geneti…
  datacite Ananddeep Patel 2026 置信度 0.66 Requested PREreview
• CRISPR-Based Genome Editing in Sickle Cell Disease: Navigating the Transition from Molecular Triumph to Pediatric Expansion
  Sickle cell disease (SCD) is the most prevalent severe monogenic disorder worldwide, historically defined by lifelong symptom management. The advent of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) genome editin…
  datacite Hammami, Mohammed Wassim 2026 置信度 0.66 Hemoglobin, Sickle/geneticsCRISPR-Cas SystemsGene therapyFetal HemoglobinHematopoietic Stem Cells
• CRISPR-Based Genome Editing in Sickle Cell Disease: Navigating the Transition from Molecular Triumph to Pediatric Expansion
  Sickle cell disease (SCD) is the most prevalent severe monogenic disorder worldwide, historically defined by lifelong symptom management. The advent of clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) genome editin…
  datacite Hammami, Mohammed Wassim 2026 置信度 0.66 Hemoglobin, Sickle/geneticsCRISPR-Cas SystemsGene therapyFetal HemoglobinHematopoietic Stem Cells
• <b>A Qualitative and Quantitative Detection Method for Gene Editor Residues Based on Cutting-Edge Biosensing Technology</b>
  This study focuses on the core pain points of the current gene editing industry, specifically addressing the residual editor issue arising from the widespread application of CRISPR/Cas9 technology. A novel, highly sensitive method for the qualitative and quant…
  datacite Zizhao Wang 2026 置信度 0.66 Sensor technology (incl. chemical aspects)
• <b>A Qualitative and Quantitative Detection Method for Gene Editor Residues Based on Cutting-Edge Biosensing Technology</b>
  This study focuses on the core pain points of the current gene editing industry, specifically addressing the residual editor issue arising from the widespread application of CRISPR/Cas9 technology. A novel, highly sensitive method for the qualitative and quant…
  datacite Zizhao Wang 2026 置信度 0.66 Sensor technology (incl. chemical aspects)
• Training school on Homology-directed repair and Adeno-associated virus based delivery technologies report
  The GenE-HumDi Training School held in Trondheim (Norway) on the 24-26 June 2026, provided an overview of Homology-Directed Repair (HDR), CRISPR-based genome editing, and adeno-associated virus (AAV)-mediated gene delivery, with a strong emphasis on their appl…
  datacite Hejlesen, Rasmus, Isabel Ojeda Pérez, Bilbao-Arribas, Martin, Bahsi, Pınar 等 2026 置信度 0.66 Gene therapyGene Editing/methodsGene EditingGene Editing/trends
• Recent advances in molecular biology and host-parasite interactions in Cuscuta spp.
  Plants of the genus Cuscuta (Cuscutaceae) are holoparasitic angiosperms that completely depend on their host plants for water, nutrients, and signaling molecules. Lacking functional roots and chlorophyll, Cuscuta species attach to their hosts through specializ…
  datacite ADAMOU BACHAROU, Souleymane 2026 置信度 0.66 Cuscutaplant parasitismhaustoriumtranscriptomicsRNA interference
• Recent advances in molecular biology and host-parasite interactions in Cuscuta spp.
  Plants of the genus Cuscuta (Cuscutaceae) are holoparasitic angiosperms that completely depend on their host plants for water, nutrients, and signaling molecules. Lacking functional roots and chlorophyll, Cuscuta species attach to their hosts through specializ…
  datacite ADAMOU BACHAROU, Souleymane 2026 置信度 0.66 Cuscutaplant parasitismhaustoriumtranscriptomicsRNA interference
• Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential
  Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional regulation of gene e…
  datacite E McHugh, MS Bulloch, Steven Batinovic, CJ Patrick 等 2023 置信度 0.66 Microbiology
• Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential
  Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional regulation of gene e…
  datacite E McHugh, MS Bulloch, Steven Batinovic, CJ Patrick 等 2023 置信度 0.66 Microbiology
• A Model to Incorporate the bHLH Transcription Factor OsIRO3 within the Rice Iron Homeostasis Regulatory Network
  Iron (Fe) homeostasis in plants is governed by a complex network of regulatory elements and transcription factors (TFs), as both Fe toxicity and deficiency negatively impact plant growth and physiology. The Fe homeostasis network is well characterized in Arabi…
  datacite O Carey-Fung, Martin O'Brien, JT Beasley, AAT Johnson 2022 置信度 0.66 Biological sciencesBiochemistry and cell biologyMicrobiologyMedicinal and biomolecular chemistry
• A Model to Incorporate the bHLH Transcription Factor OsIRO3 within the Rice Iron Homeostasis Regulatory Network
  Iron (Fe) homeostasis in plants is governed by a complex network of regulatory elements and transcription factors (TFs), as both Fe toxicity and deficiency negatively impact plant growth and physiology. The Fe homeostasis network is well characterized in Arabi…
  datacite O Carey-Fung, Martin O'Brien, JT Beasley, AAT Johnson 2022 置信度 0.66 Biological sciencesBiochemistry and cell biologyMicrobiologyMedicinal and biomolecular chemistry
• Simulated PacBio HiFi and ONT data for ALPINE benchmark
  This dataset contains four simulated long-read sequencing files used for benchmarking CRISPR gene editing outcome classification tools in the ALPINE manuscript. The simulated datasets represent CRISPR-Cas9 editing experiments at two T cell receptor loci (TRAC …
  datacite Chen, Maggie, Gao, Xing-Huang 2026 置信度 0.66
• Simulated PacBio HiFi and ONT data for ALPINE benchmark
  This dataset contains four simulated long-read sequencing files used for benchmarking CRISPR gene editing outcome classification tools in the ALPINE manuscript. The simulated datasets represent CRISPR-Cas9 editing experiments at two T cell receptor loci (TRAC …
  datacite Chen, Maggie, Gao, Xing-Huang 2026 置信度 0.66
• CRISPR-Cas9 gene editing and rapid detection of gene-edited mutants using high-resolution melting in the apple scab fungus, Venturia inaequalis
  Apple scab, caused by the fungal pathogen Venturia inaequalis, is the most economically important disease of apple (Malus x domestica) worldwide. To develop durable control strategies against this disease, a better understanding of the genetic mechanisms under…
  datacite M Rocafort, S Arshed, D Hudson, JS Sidhu 等 2022 置信度 0.66 Biological sciencesMicrobiologyPlant biology
• A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and <i>in vivo</i> validation of HBV host factors
  preprints 2026 置信度 0.74
• CRISPR-based epigenome and genome editing reveal novel roles for PLEC in cartilage biology, mechanobiology, and response to inflammation
  preprints 2026 置信度 0.74
• A survey of multi-targeting and off-targeting sgRNAs across five genome-wide CRISPR-Cas9 knockout sgRNA libraries with GuideRefine
  preprints 2026 置信度 0.74
• In vivo gene disruption and homology-directed repair in muscles and muscle stem cells using CRISPR/Cas9
  preprints 2026 置信度 0.74
• dCas allele sequestration (das-CRISPR): A Versatile New Method to Achieve Monoallelic Gene Editing in Mouse Embryos and in cell culture
  preprints 2026 置信度 0.74
• CRISPR-Cas9 Induced Knockout of <i>BEL5</i> in Tetraploid Potato: Optimized Methodology via Repeated <i>de novo</i> Regeneration and Impact on Tuberization
  preprints 2026 置信度 0.74
• CRISPR/Cas9 knockout and editing of the major cysteine protease in <i>Entamoeba histolytica</i>
  preprints 2026 置信度 0.74
• Ommochrome pathway knockout via CRISPR/Cas9 reveals sex-linked eye pigmentation and establishes a heritable genome-editing platform in Rhynchophorus ferrugineus
  preprints 2026 置信度 0.74
• A self-regulating dCas9 system enables robust, portable and multiplexed CRISPR interference
  preprints 2026 置信度 0.74
• Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology
  preprints 2026 置信度 0.74
• EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing
  preprints 2026 置信度 0.74
• Application of AI-Designed OpenCRISPR-1 for Highly Efficient Gene Editing in Soybean and Nicotiana benthamiana
  preprints 2026 置信度 0.74
• Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells
  preprints 2026 置信度 0.74
• CRISPR-Cas9 Therapeutics in Diabetes Mellitus: From Molecular Mechanisms and Pharmacology to Clinical Development and Translational Barriers
  preprints 2026 置信度 0.74
• CRISPR/Cas9 genome editing to generate single variant <i>Plasmodium falciparum</i> lines and enable reverse genetic studies of PfEMP1 function in live parasites
  preprints 2026 置信度 0.74
• How many genes can CRISPR edit to engineer complex adaptations?
  preprints 2026 置信度 0.74
• CRISPR-mediated Correction of Oncogenic AS-NMD in Splicing Factor Mutant Cancer
  preprints 2026 置信度 0.74
• CRISPR-Cas9–Mediated Genome Editing in Avocado: Advances in Editing Efficiency and Regeneration
  preprints 2026 置信度 0.74