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• Genetic transformation and CRISPR/Cas12a-mediated gene editing of European beech (Fagus sylvatica L.) employing a transient protoplast system.
  europepmc 2026 置信度 0.80
• UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems.
  europepmc 2026 置信度 0.80
• Translating CRISPR to Practice in the Clinic: Transformative Therapy in Hemoglobinopathies and Emerging Applications in Malignancies.
  Exagamglogene autotemcel, the first clustered regularly interspaced short palindromic repeats (CRISPR)-based gene-editing therapy to enter clinical practice, has established genome editing as a curative-intent option for eligible patients with severe sickle ce…
  pubmed Salim Hammoud M, Hanna R 2026 置信度 0.82
• Rapid PCR-based screening system for detection of type II CRISPR-Cas loci in bacterial species
  europepmc 2026 置信度 0.80
• Recent advances of CRISPR-based gene editing technologies and delivery strategies.
  europepmc 2026 置信度 0.80
• CRISPR–Cas9 gene editing as a tool for developing immunotherapy for cancer
  T cells following genome editing and transformation might be detectable in peripheral blood and tumor tissues for a long time, even more than a year. The types and diversity of T-cells in peripheral blood and tumor tissues changed following transfusion of gene…
  crossref Moataz Dowaidar 2021-06-10T22:36:31Z 置信度 0.70
• Editing of the coatomer protein complex subunit alpha gene in bovine blastocysts using CRISPR/Cas9
  crossref Mikhael Poirier 2020-02-19T17:28:53Z 置信度 0.70
• Comparative Study Between the CRISPR/Cpf1 and CRISPR/Cas9 systems for Multiplex Gene Editing in Maize
  Abstract Background: The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system has been successfully used for multiplex gene editing in crops. Although CRISPR/Cas9 system has been proved to be an efficient mu…
  crossref Chongzhi Gong, Shengchan Huang, Rentao Song, Weiwei Qi 2021-02-19T01:05:33Z 置信度 0.70
• Gene Editing and Healthcare Applications
  crossref Sanika Kathale 2023-09-15T22:16:52Z 置信度 0.70
• Genetic Editing Out the Tumor Growth Supressor Gene TRM9L in Colorectal Cancer Models Using CRISPR-Cas9
  crossref Philip Blatner 2025-06-27T18:44:23Z 置信度 0.70
• The use of CRISPR/Cas9 gene editing in cancer research and therapy
  The use of CRISPR/Cas9 gene editing in cancer researchand therapy
  crossref ahmed malik 2023-04-06T05:01:40Z 置信度 0.70
• CRISPR-based gene editing is presently being tried in many clinical trials
  CRISPR is a bacterial host defense system that may work as "molecular scissors" in eukaryotic cells to permanently modify genetic coding. Some barriers to using CRISPR as a therapeutic include guaranteeing adequate delivery of the RNP complex to the proper cel…
  crossref Moataz Dowaidar 2021-06-10T23:36:28Z 置信度 0.70
• A CRISPR-Cas9 Technique for Gene Editing in T Cells
  crossref 2024-05-31T20:06:28Z 置信度 0.70
• Moving from in vitro to in vivo CRISPR screens
  crossref Maria Kuhn, António J. Santinha, Randall J. Platt 2021-05-31T12:35:15Z 置信度 0.70
• Gene Editing as a Potential Cure for Epidermodysplasia Verruciformis (EV): A CRISPR-Based Approach
  crossref Amir Reza Ramezani 2025-03-30T08:04:46Z 置信度 0.70
• Gene editing in filamentous fungi and oomycetes using CRISPR-Cas technology
  crossref Sanjoy Kumar Paul, Tasmina Akter, Tofazzal Islam 2021-03-07T16:50:24Z 置信度 0.70
• A CRISPR-Cas9 Technique for Gene Editing in T Cells
  crossref 2025-07-31T18:33:18Z 置信度 0.70
• A CRISPR-Cas9 Technique for Gene Editing in T Cells
  crossref 2024-05-31T20:08:52Z 置信度 0.70
• CRISPR editing of CHMP2B gene in KOLF2.1J AAVS-NGN2 iPSCs v1
  This protocol describes a method for either knock out of CHMP2B, as well as knockin of CHMP2B Q165X or CHMP2B I29V in human KOLF2.1J AAVS1-NGN2 iPSCs; (see protocol: dx.doi.org/10.17504/protocols.io.kqdg3x99eg25/v1) cells using either CAS9 or Cpf1 and electrop…
  crossref Harper JW, jiuchun_zhang@hms.harvard.edu not provided 2025-01-28T11:55:55Z 置信度 0.70
• CRISPR-Cas Systems in Insects and Other Arthropods
  crossref Arjumand John, Amaninder Kaur Riat, Kaisar Ahmad Bhat, Aarif Ali 2025-07-04T10:41:22Z 置信度 0.70
• Application of CRISPR for Plant-Mediated Resistance
  crossref Lini Sethi, Manas K. Tripathy 2024-03-18T08:02:35Z 置信度 0.70
• Gene Editing Using CRISPR/Cas9 System
  crossref Gopika, Boro Arthi, Arumugam Vijaya Anand, Natchiappan Senthilkumar 等 2024-03-05T19:34:56Z 置信度 0.70
• The Applications of the CRISPR/Cas9 Gene-Editing System in Treating Human Diseases
  In the early 2010s, scientists realized that CRISPR/Cas9, a bacterial immune defense system against viruses that involves the CRISPR-associated protein #9 (Cas9) endonuclease enzyme, single-guide RNAs (sgRNAs), and PAM recognition, could be used to intentional…
  crossref Akanksha Varanasi, Elisabeth Wilson 2022-08-11T12:42:11Z 置信度 0.70
• Review for "Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches"
  crossref 2026-04-23T21:11:07Z 置信度 0.70
• Gene Editing and CRISPR Therapeutics: Strategies Taught by Cell and Gene Therapy
  crossref Juan C. Ramirez 2017-09-19T08:16:02Z 置信度 0.70
• Combined Use of Unidirectional Site-Specific Recombination System and CRISPR-Cas Systems for Plant Genome Editing
  crossref Yuan-Yeu Yau, Mona Easterling, C. Neal Stewart 2024-03-18T08:02:35Z 置信度 0.70
• 3D's of Genome Editing Systems: Discovery, Developments, and Diversity
  crossref Zulqurnain Khan, Shakeel Ahmad 2025-04-01T15:32:44Z 置信度 0.70
• CRISPR-Cas Systems in Neurological Diseases
  crossref Aarif Ali, Bashir Ahmad Malla, Mohammad Saleem Bhat, Javeed Iqbal Ahmad Bhat 2025-07-04T10:41:22Z 置信度 0.70
• Precise Gene Editing of Cereals Using CRISPR/Cas Technology
  Abstract Targeted mutagenesis using CRISPR/Cas technology has become routine in elucidating biological processes or their application in breeding and agriculture. This means that the change to be achieved can be accurately predicted. However, knockout of a gen…
  crossref Pouneh Pouramini, Goetz Hensel 2023-12-14T15:02:46Z 置信度 0.70
• Nobel Prize for chemistry honors exquisitely precise gene-editing technique, CRISPR – a gene engineer explains how it works
  crossref Piyush Jain 2025-08-25T19:19:36Z 置信度 0.70
• Review for "Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches"
  crossref 2026-04-23T21:11:07Z 置信度 0.70
• A Promising Therapy in Cancer Treatment: CRISPR-Cas9 Gene Editing, Its Improvements, Combination Therapies, and Future Developments
  crossref Yuman Sui 2026-01-27T11:17:51Z 置信度 0.70
• Recovering Practical Wisdom as a Guide for Human Flourishing
  This chapter argues that practical wisdom understood according to the classic Christian tradition of Thomas Aquinas can contribute to reflection on complex decision-making when considering new genetic technologies such as CRISPR-Cas9 and their potential relati…
  crossref Celia Deane-Drummond 2019-08-21T07:25:38Z 置信度 0.70
• Review for "Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches"
  crossref 2026-04-23T21:11:07Z 置信度 0.70
• Trends in CRISPR/Cas9 Editing Technology as an Approach for Climate-Smart Agriculture
  crossref Samina Yasmin, Amjad Ali, Muhammad Tatar, Jaweria Iqbal 2026-04-01T14:14:25Z 置信度 0.70
• Editing a Stomatal Developmental Gene in Rice with CRISPR/Cpf1
  crossref Xiaojia Yin, Abhishek Anand, Paul Quick, Anindya Bandyopadhyay 2019-01-04T17:14:42Z 置信度 0.70
• Ordo-Responsibility for Germline Gene Editing
  The case of twins born with genes modified by He Jiankui highlights the need for international governance of germline gene editing (GGE). This article proposes a global framework that utilizes “ordo-responsibilities.” This is a pragmatic ethical approach open …
  crossref Robert Ranisch, Tina Rudolph, Hans-Joachim Cremer, Nikolaus Knoepffler 2020-02-24T11:14:18Z 置信度 0.70
• Review for "Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR-Based β-Cell Replacement and Treg Immune Modulation Approaches"
  crossref 2026-04-23T21:11:07Z 置信度 0.70
• Review for "CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells"
  crossref 2021-11-29T09:18:56Z 置信度 0.70
• CCR5-Δ32 biology, gene editing, and warnings for the future of CRISPR-Cas9 as a human and humane gene editing tool
  Abstract Background Biomedical technologies have not just improved human health but also assisted in the creation of human life. Since the first birth of a healthy baby by in vitro fertilization (IVF) 40 years ago, IVF has been the mainstay treatment for coupl…
  crossref MengMeng Xu 2020-03-30T16:04:09Z 置信度 0.70
• What is CRISPR, the gene editing technology that won the Chemistry Nobel prize?
  crossref Dimitri Perrin 2025-08-25T19:19:36Z 置信度 0.70
• Gene Editing Using CRISPR
  crossref Anthony L. Komaroff 2017-08-10T16:32:10Z 置信度 0.70
• Guide RNA Engineering Enables Dual Purpose CRISPR-Cpf1 for Simultaneous Gene Editing and Gene Regulation in Yarrowia lipolytica
  crossref 2020-04-09T09:51:15Z 置信度 0.70
• Review for "CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells"
  crossref 2021-11-29T09:18:56Z 置信度 0.70
• Gene Editing Governance and Genetic Engineering: A Framework for Regulating CRISPR Technology
  crossref Christian Kaunert, Richa Raghav 2026-06-05T11:29:32Z 置信度 0.70
• Gene-editing technique CRISPR identifies dangerous breast cancer mutations
  crossref Jay Shendure, Lea Starita, Greg Findlay 2025-08-26T01:24:18Z 置信度 0.70
• CRISPR gene-editing controversy shows old ideas about East and West still prevail
  crossref Calvin Ho 2025-08-26T07:40:07Z 置信度 0.70
• Peer Review #1 of "Genetic editing of the virulence gene of Escherichia coli using the CRISPR system (v0.1)"
  crossref 2020-04-11T02:31:17Z 置信度 0.70
• Correction to: Application of CRISPR/Cas9-Mediated Gene Editing in Tomato
  crossref Nathan T. Reem, Joyce Van Eck 2023-03-10T08:03:04Z 置信度 0.70
• Creating Hypoallergenic and Low Antinutritional Soybeans through CRISPR/Cas12a-Mediated Multiplex Gene Editing
  crossref 2025-11-07T14:21:12Z 置信度 0.70
• 14 CRISPR GENE EDITING
  crossref Michael Le Page 2026-01-24T00:18:47Z 置信度 0.70
• Powerful enzyme could make CRISPR gene-editing more versatile
  crossref Heidi Ledford 2018-05-14T14:42:54Z 置信度 0.70
• Strategies for Delivering Crispr-Cas Reagents Into Plants
  crossref Luan Luong Chu, Nguyen Quang Huy 2025-04-01T15:32:44Z 置信度 0.70
• Peer Review #3 of "Genetic editing of the virulence gene of Escherichia coli using the CRISPR system (v0.1)"
  crossref 2020-04-11T02:31:15Z 置信度 0.70
• Could gene editing tools such as CRISPR be used as a biological weapon?
  crossref James Revill 2025-08-26T06:13:43Z 置信度 0.70
• To CRISPR or Not to CRISPR? Ethical Considerations in Gene-Editing Insects
  crossref Brendan Parent, Meghan Barrett 2024-09-09T06:01:41Z 置信度 0.70
• Review for "CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells"
  crossref 2021-11-29T09:18:56Z 置信度 0.70
• Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing
  crossref 2020-04-08T14:38:15Z 置信度 0.70
• Rapid and Efficient Gene Deletion by CRISPR/Cas9
  crossref Signe Neldeborg, Lin Lin, Magnus Stougaard, Yonglun Luo 2019-03-25T09:03:05Z 置信度 0.70
• U.K. Team Reports CRISPR-Induced Gene Rearrangements: New Findings Call the Precision of CRISPR-Cas9 Gene Editing into Question
  crossref Julianna LeMieux 2018-09-11T17:01:27Z 置信度 0.70
• Improvements in the genetic editing technologies: CRISPR-Cas and beyond
  crossref Gerard Mingarro, Marcel lí del Olmo 2022-11-24T12:56:27Z 置信度 0.70
• CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells
  Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated cell types allows the study of the genetic regulation of human development and disease. The translational potential of hPSC is maximized by exploiting CRISPR t…
  crossref Max van Essen, Joey Riepsaame, John Jacob 2021-09-28T17:27:07Z 置信度 0.70
• Multiplexed CRISPR/Cas9 Genome Editing and Gene Regulation Using Csy4 in Saccharomyces cerevisiae
  crossref 2020-04-06T07:48:41Z 置信度 0.70
• Beyond the CRISPR-Cas9 System
  crossref Aarif Ali, Mohammad Saleem Bhat, Javeed Iqbal Ahmad Bhat, Sadhna Aggarwal 等 2025-07-04T10:41:22Z 置信度 0.70
• An Examination of Public Discourse on Human Gene Editing Using Natural Language Processing
  This research aims to explore the different ways in which scientists, ethicists, journalists, and commissions speak to the public about new gene-editing technologies. The research collected more than 100,000 sentences from books, news articles, and reports wri…
  crossref Micah Musser 2020-08-24T16:53:59Z 置信度 0.70
• Review for "Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment"
  crossref 2019-06-25T13:25:55Z 置信度 0.70
• Gene Editing and Human Rights: Legal Implications of CRISPR Technology
  crossref Fatima Zahra Ouariach, Manmeet Kaur Arora 2026-06-05T11:29:32Z 置信度 0.70
• CRISPR-Cas9 Gene Editing for Enhancing Disease Resistance in Cattle
  crossref Xiaofang Lin 2025-07-11T08:53:36Z 置信度 0.70
• CRISPR-mediated Gene Editing of Two AGAMOUS-like Genes in Domestic Apple
  crossref Amy Klocko 2020-09-30T08:58:12Z 置信度 0.70
• CRISPR-Cas Systems
  crossref Bashir Ahmad Malla, Aarif Ali, Nuzhat Khursheed, Mohammad Saleem Bhat 等 2025-07-04T10:41:22Z 置信度 0.70
• Biomimetic Mineralized CRISPR/Cas RNA Nanoparticles for Efficient Tumor-Specific Multiplex Gene Editing
  crossref 2023-07-23T09:00:45Z 置信度 0.70
• CRISPR-Based Gene Editing
  crossref Lun Suo 2019-04-24T03:06:00Z 置信度 0.70
• Research on CRISPR-Cas9 Gene Editing Technology in Cancer Treatment
  Gene editing technology represents a pioneering biotechnology that leverages molecular tools to achieve efficient and precise modifications of the DNA sequences within a biological genome, enabling the regulation of gene functions or the enhancement of traits.…
  crossref Shengxue Zhang 2025-10-23T13:09:15Z 置信度 0.70
• CRISPR-Cas Systems for Genome Editing
  crossref Nayla Munawar, Rabail Afzal, Aftab Ahmad, Anam Niamat 2025-05-22T07:43:58Z 置信度 0.70
• CRISPR-directed gene-editing induces genetic rearrangement within the human globin gene locus
  crossref Olivia Tharp, Brett M. Sansbury, Eric B. Kmiec 2024-08-22T21:03:06Z 置信度 0.70
• Simulation of CRISPR/Cas9 Mediated Gene Editing for Vitellogenin Gene (Vg) in Honeybees   Short title: In Silico CRISPR/Cas9 Targeting of Vitellogenin in Honey Bees
  Abstract CRISPR/Cas9 genome editing provides a powerful framework for interrogating gene function in honey bees (Apis mellifera). Yet, empirical application remains challenging due to biological constraints, including haplodiploid genetics, narrow embryonic in…
  preprints Peymaneh Davoodi, Marzieh Atapour, Arezoo Shahsavari, Rozbeh Kiani 2026 置信度 0.74
• Using CRISPR/Cas9 to investigate the role of candidate human disease gene orthologs in Ciona
  preprints 2026 置信度 0.74
• A Curated Spatial Transcriptomic Dataset of the Human Adrenal Gland Cortex and Medulla
  preprints 2026 置信度 0.74
• Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow
  preprints 2026 置信度 0.74
• A Synthetic Minimal Genome Design Framework for Bacteriophages: Application to <em>Streptococcus mutans</em> and Broad-Host-Range Expression in <em>Escherichia coli</em>
  Minimal genome design, reducing a system to its smallest functional part set, is a core synthetic-biology strategy. Bacteriophages are attractive but underused chassis, yet wild-type phages are difficult to engineer. We present a comparative genomics-guided fr…
  preprints 2026 置信度 0.74
• Genome evolution during the domestication of an antibiotic-producing Streptomyces strain
  preprints 2026 置信度 0.74
• Anniemap: Vector Search for Viral Short Read Alignment
  Background The process of aligning sequencing reads to a reference genome is a foundational step in genomic analysis, underpinning tasks from variant detection to pathogen surveillance. In viral genomics, however, this problem becomes substantially more challe…
  preprints 2026 置信度 0.74
• An accessible Galaxy-based workflow for comparative genomic analysis of ESBL-producing Enterobacterales bloodstream isolates ​
  preprints 2026 置信度 0.74
• Scarless conditional sgRNAs via endogenous mascRNA processing enable rapid and temporally controlled genome editing
  preprints 2026 置信度 0.74
• PanGBank: a large-scale resource of precomputed microbial pangenomes built with PPanGGOLiN
  preprints 2026 置信度 0.74
• WiDiPo: A Collection of Wild Diploid Potato for Enhancement of Breeding Germplasm
  preprints 2026 置信度 0.74
• Mutation mapping and evolutionary dynamics of Bundibugyo Ebolavirus (BDBV-2026) genomes reported from Uganda
  preprints 2026 置信度 0.74
• Gene model for the ortholog of <i>tgo</i> in <i>Drosophila persimilis</i>
  preprints 2026 置信度 0.74
• An Oligomeric Lanthipeptide from <i>Nostoc punctiforme</i> Promotes Host Association During Early Symbiosis with <i>Blasia pusilla</i>
  preprints 2026 置信度 0.74
• SAM-Targeted CRISPR-Cas9 RNP Delivery Combined with Leaf Regeneration Enables DNA-Free, Non-Chimeric Genome Editing in ‘Fuji’ Apple
  preprints 2026 置信度 0.74
• Chromosome assembly for the Black bean aphid <i>Aphis fabae</i>
  preprints 2026 置信度 0.74
• Molecular sources of monoterpenoid chemodiversity in the Asteraceae Tanacetum vulgare suggest a new model for the evolution of specialized metabolism
  preprints 2026 置信度 0.74
• GWAS and multimodal transcriptomic profiling of human otolithic organs characterize the genetic architecture of balance in the elderly
  preprints 2026 置信度 0.74
• SpatialJEPA: JEPA-inspired graph-context distillation for spatially aware multiomics integration
  preprints 2026 置信度 0.74
• Identification of the Novel HLA-B*57:212 Allele by Next-Generation Sequencing.
  HLA-B*57:212 differs from HLA-B*57:01:01:01 by a single nucleotide substitution in exon 5.
  pubmed Harfouch E, Paré B, Chamillard X, Le Toriellec E 等 2026 Sep 置信度 0.82
• Identification of Two Novel HLA-DQB1 Alleles, HLA-DQB1*02:239 and HLA-DQB1*02:271.
  Compared with HLA-DQB1*02:02:01:01, the alleles HLA-DQB1*02:239 and HLA-DQB1*02:271 each show one nucleotide substitution, respectively.
  pubmed Pi W, Wang F, Chen N, Zhang W 等 2026 Sep 置信度 0.82
• Uncovering Potential Druggable Targets in Coronary Atherosclerosis: A Proteome-Wide Mendelian Randomization Study With Cross-Platform and Experimental Validation.
  Coronary atherosclerosis (CA) is a leading cause of cardiovascular morbidity and mortality worldwide. This study is aimed at identifying candidate plasma proteins and potential therapeutic targets for CA.
  pubmed Gao D, Lin H, Wang S, Wang Y 等 2026 置信度 0.82
• Characterisation of the Novel HLA-DRB3*01:127 Allele by Next-Generation Sequencing.
  HLA-DRB3*01:127 differs from the HLA-DRB3*01:01:02:01 allele by one nucleotide substitution in the exon 3.
  pubmed Pi W, Dong L, Li Q, Zhang W 等 2026 Sep 置信度 0.82
• Gene-level complexity explains genome-wide variation in the distribution of fitness effects.
  The distribution of fitness effects (DFE)-describing how harmful, neutral, or beneficial new mutations are-is central to understanding how populations evolve. Although the DFE varies across genomes and species, it remains unclear which aspects of genomic organ…
  pubmed Yıldırım B, James JE 2026 Aug 26 置信度 0.82
• AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors.
  WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementati…
  pubmed Sarkar C, Al-Hussaini M, Santosh V, Suri V 等 2026 Aug 29 置信度 0.82