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Here, we report the complete coding sequence of the avian influenza A virus subtype H1N3 from guinea fowl [A/Guinea fowl/Serbia/Vinca_household/2025(H1N3)] obtained on the Oxford Nanopore Technologies MinION device in combination with an amplicon-based protoco…
pubmed
Vidanović D, Maletić J, Šekler M, Tešović B 等
2026 Jul 29
置信度 0.82
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Digital multidomain interventions hold promise for dementia risk reduction; however, populations at higher dementia risk, including those experiencing socioeconomic and educational disadvantage, remain underrepresented in trials, and engagement with digital in…
pubmed
Yu CTK, Livingston G, Allan L, Boczko R 等
2026 Jul 29
置信度 0.82
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The 2030 Agenda for Sustainable Development highlights the urgent need for a profound transformation in food production and consumption to enhance both sustainability and human health. The aim of this study is to provide both the general population and food sy…
pubmed
Lopez-Garcia E, Bretón-Lesmes I, Díaz-Perales A, Moreno-Arribas MV 等
2026 Jul 28
置信度 0.82
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The discovery of tRNA as an adapter molecule established the foundation for understanding its essential roles in gene expression, stress responses, cellular homeostasis, and disease, including viral infections. Human tRNAs carry multiple chemical modifications…
pubmed
Madhry D, Meena V, Roy R, Aziz A 等
2026 Jul-Aug
置信度 0.82
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Clostridioides difficile infection (CDI) remains a priority for infection prevention and control in healthcare, particularly with the emergence of hypervirulent strains and antimicrobial resistance (AMR).
pubmed
Unsworth A, Fong W, Kong FR, Wang Q 等
2026 Jul 28
置信度 0.82
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pubmed
Jiang Y, Jiang M, Lu X, Yan M 等
2026 Aug
置信度 0.82
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Azacitidine (Aza) plus venetoclax (Ven) is standard treatment for older/unfit patients with newly diagnosed (ND) acute myeloid leukemia (AML). The approved 28-day (D) Ven schedule is associated with prolonged cytopenias, causing frequent dose reductions and cy…
pubmed
Borate UM, Huang Y, Lin TL, Handa S 等
2026 Jul 28
置信度 0.82
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[This corrects the article DOI: 10.3389/fstro.2025.1562048.].
pubmed
Olalusi OV, Yaria J, Makanjuola A, Akinyemi R 等
2026
置信度 0.82
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Carbapenemase-producing Enterobacterales (CPE) represent a major global health threat due to limited therapeutic options and high mortality. While isolates harboring a single carbapenemase are increasingly common, polymicrobial bloodstream infections involving…
pubmed
Cury AP, Rodrigues KA, Ribeiro E, Araujo A de Araujo EDM 等
2026
置信度 0.82
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Disease caused by nontuberculous mycobacteria (NTM) is often misdiagnosed as tuberculosis (TB) in India. Comprehensive studies on NTM are lacking, therefore, the present study aimed to describe clinical features, underlying conditions, species distribution, an…
pubmed
Sharma SK, Upadhyay V, Mohan A, Dewan RK 等
2026 Aug
置信度 0.82
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Mosquito-borne chikungunya virus (CHIKV) causes acute febrile illness with potentially persisting polyarthralgia, and its global resurgence in international travelers poses a risk of importation into non-endemic regions.
pubmed
Equihua Martinez G, Lindner AK, Thielecke M, Hammer J 等
2026 Aug
置信度 0.82
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The Danish Lymphoid Cancer Research (DALY-CARE) Genetic Cohort was established to support research into how genetic factors influence clinical outcomes in lymphoid cancers (LCs), including disease progression, treatment response, toxicity, and survival. Indivi…
pubmed
Dietz JB, Kadlec TF, Rotbain EC, Werling M 等
2026
置信度 0.82
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The gut microbiome is a promising source of non-invasive biomarkers for colorectal cancer (CRC), yet the diagnostic performance remains heterogeneous, and the identified key markers often have inconsistency across studies, potentially influenced by host-specif…
pubmed
Chejara P, Eriksson A
2026
置信度 0.82
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To review immunological studies in idiopathic orbital inflammation (IOI) to characterize immune cells, mediators and pathways to strengthen diagnostic evaluation, and identify priorities for future research.
pubmed
Scheel-Bech AB, Iversen L, Klefter ON, Subhi Y 等
2026 Jul 28
置信度 0.82
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Mucopolysaccharidoses (MPS) are heterogeneous group of disorders caused by the deficiency of lysosomal enzymatic activities. Deficiencies in these enzymes are required for proper degradation of glycosaminoglycans (GAGs), thus referred as inborn errors of lysos…
pubmed
Bilal M, Fakhar M, Eid T, Helmi N 等
2026 Jul 28
置信度 0.82
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Foot-and-mouth disease (FMD) causes severe global economic loss, necessitating rapid viral characterization. Nanopore sequencing provides a simple, real-time workflow suitable for on-site outbreak response, addressing the limitations of conventional methods. I…
pubmed
Jeon JH, Ryoo S, Kang H, Kim J 等
2026 Jul 28
置信度 0.82
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Juvenile Asian elephants who have lost maternal antibodies are particularly susceptible to fatal hemorrhagic disease caused by primary infection with elephant endotheliotropic herpesvirus 1A (EEHV1A). To address this vulnerability, a multi-antigen EEHV1A mRNA …
pubmed
Wenninger M, Farris L, Heinz J, Peng R 等
2026 Aug 18
置信度 0.82
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Community-based participatory research (CBPR), a research approach that centers the collective strengths of community-researcher partnerships, can direct future genetic counseling (GC) research initiatives toward issues that are critical to communities most im…
pubmed
Johnson VR, Fisher ER, Culhane-Pera KA, Lumpkins CY 等
2026 Aug
置信度 0.82
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Our aim was to systematically review and meta-analyse evidence on the association between pulse pressure (PP) and cognitive function using PubMed, PsycInfo, Embase and Scopus (inception-July 2025) publication databases. Studies were included if they reported a…
pubmed
Gaunt O, Venkatesh K, McNally R, Chowienczyk PJ 等
2026 Oct 1
置信度 0.82
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The decision by the co-Editor-in-Chief of Regulatory Toxicology and Pharmacology, Prof. Martin van den Berg, to retract the 2000 review article by Williams, Kroes, and Munro has elicited widespread criticism within the scientific community. Issued in late 2025…
pubmed
Borgert CJ, Abdollahi M, Ansell JM, Aschner M 等
2026
置信度 0.82
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Personalized oncology is transforming cancer care by tailoring therapeutic strategies to the molecular and clinical characteristics of individual patients. However, increasing treatment complexity, interpatient variability, and the growing use of advanced ther…
pubmed
Mascarenhas-Melo F, Pinheiro R, Victor F, Pina ME 等
2026 Jul 13
置信度 0.82
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The H5N1 highly pathogenic avian influenza (HPAI) virus has caused severe global losses, reaching South America in 2022 and Antarctica in 2024. Here, we synthesize outbreak reports submitted to the World Organization for Animal Health by South American countri…
pubmed
Sánchez-Rodríguez F, Diaz-Gavidia C, Ruíz S, Jimenez-Bluhm P
2026 Jul 12
置信度 0.82
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The genus Orthopestivirus , within the family Flaviviridae , includes important pathogens such as classical swine fever virus (CSFV), bovine viral diarrhea virus types 1 and 2 (BVDV-1 and BVDV-2), and border disease virus (BDV). Although Costa Rica is endemic …
pubmed
León B, Chacón I, Víquez E, Aguilar O 等
2026 Jul 11
置信度 0.82
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Avian influenza viruses (AIVs) are widely distributed and have a wide range of hosts. Recently, the number of cases of infection associated with the circulation of highly pathogenic avian influenza H5N1 2.3.4.4b has raised concerns about its high transmission …
pubmed
Garcia YLNL, Lima FH, Geraldini DB, Gomes AJC 等
2026 Jul 3
置信度 0.82
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Enterovirus G (EV-G) is an important enteric pathogen widely circulating in swine populations and is characterized by considerable genetic diversity and recombination potential. In recent years, recombinant EV-G strains carrying exogenous papain-like cysteine …
pubmed
Jiang K, Li B, Wu X, Zhao W 等
2026 Jun 26
置信度 0.82
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Urinary tract infections are among the most common bacterial infections encountered in clinical practice, with Escherichia coli representing the dominant urinary pathogen. Increasing detection of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-…
pubmed
Saeed U, Uppal R, Zaman G, Uppal MR 等
2026 Jul 20
置信度 0.82
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Plague remains a significant natural focal zoonotic infection with continuing epidemiological relevance in the Republic of Kazakhstan. This study provides a comprehensive assessment of epizootological dynamics in natural plague foci during 2020-2025 through th…
pubmed
Abdel Z, Zhumadilova Z, Mussagalieva R, Abdirassilova A 等
2026 Jun 29
置信度 0.82
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Feline and canine coronaviruses (FCoVs and CCoVs) are widely prevalent in companion animals. The recent emergence of a highly virulent FCoV-CCoV recombinant virus, FCoV-23, caused a rapid feline infectious peritonitis (FIP) outbreak in Cyprus, which raises a s…
pubmed
Lin Y, Zhu X, Meng Y, Zou J 等
2026 Jul 7
置信度 0.82
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Brucellosis remains a critical zoonotic threat to public health and livestock economies globally, particularly constraining small ruminant productivity in Africa, yet continental data remain scarce. The objectives of this review are to provide apparent small r…
pubmed
Ghebrezgabher WS, Ge J, Song G, Zheng F 等
2026 Jun 30
置信度 0.82
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Porcine rotavirus (PoRV) has emerged as a primary pathogen causing viral diarrhea in pigs, resulting in significant economic losses. This study was conducted to systematically characterize the epidemiology and genotypic characteristics of PoRV in Guangxi, Chin…
pubmed
Zhao S, Wu X, He Y, Lin J 等
2026 Jun 29
置信度 0.82
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Porcine circovirus type 5 (PCV5) is a recently reported porcine-associated CRESS DNA virus, but information regarding its occurrence, genomic characteristics, and evolutionary relationship remains limited. In this study, a total of 100 diagnostic samples colle…
pubmed
Zhang JQ, Li JX, Qu HL, Miao YJ 等
2026 Jun 25
置信度 0.82
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Amino acid permeases (AAPs) facilitate the uptake and transmembrane transport of amino acids and play critical roles in regulating plant growth, development, and stress responses. However, the characteristics and functions of the AAP gene in pepper remain uncl…
pubmed
Zhang J, Zhou Z, Shi X, Cui X 等
2026 Jul 14
置信度 0.82
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The increasing threat posed by wheat rust diseases caused by Puccinia spp. necessitates the development of resistance strategies that extend beyond conventional race-specific mechanisms. Although recent reviews (2023-2025) have emphasized gene discovery and ge…
pubmed
Kenzhebayeva S, Abekova A, Omirbekova N, Shoinbekova S 等
2026 Jul 10
置信度 0.82
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Plant endophytes can regulate host plant growth, improve stress resistance, and facilitate the biosynthesis of secondary metabolites, with great research value and application potential. However, traditional approaches for the isolation, cultivation and identi…
pubmed
Chen X, Wang J, Tang L, Zeng Z 等
2026 Jul 9
置信度 0.82
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Calpains constitute an ancient, extensive family of calcium-dependent cysteine proteases found in some bacteria and most eukaryotes. They are involved in a wide variety of developmental and cellular processes and are implicated in major human diseases, but whe…
pubmed
Fletcher JC, Biggs MA, Opsahl-Sorteberg HG
2026 Jul 17
置信度 0.82
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Multidrug-resistant (MDR) Klebsiella pneumoniae is a critical cause of nosocomial infections associated with high mortality. Of particular concern is the genomic convergence of multidrug resistance and hypervirulence (MDR-hvKP), which represents a severe publi…
pubmed
Quispe Oré K, Salazar-Granara A, Cueva Távara M, Huancachoque Molina J 等
2026 Jul 19
置信度 0.82
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Klebsiella pneumoniae has become a critical global public health threat due to the rapid spread of hypervirulent and multidrug-resistant clones. A total of 205 non-duplicate K. pneumoniae isolates were collected from seven hospitals in Huzhou, China, between J…
pubmed
Ji L, Zhang P, Zha Y, Dong F 等
2026 Jul 9
置信度 0.82
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Aspartic proteases (APs), a class of proteolytic enzymes involved in protein maturation, degradation, and signaling, are known to contribute to fungal virulence and pathogenicity. However, the AP gene family in Talaromyces marneffei ( T. marneffei ), a dimorph…
pubmed
Zhao S, Chen J, Zhang Y, Ou J 等
2026 Jul 6
置信度 0.82
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Extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) is an important antimicrobial-resistant pathogen, and wastewater may serve as a reservoir for its persistence and dissemination. This study investigated the virulence-associated gene…
pubmed
Aworh MK, Reggans CW, Sellars MS, Deutschlander JC 等
2026 Jun 30
置信度 0.82
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Background : Congenital ichthyoses are a clinically and genetically heterogeneous group of Mendelian disorders of cornification. According to the 2025 classification, non-syndromic epidermal differentiation disorders (nEDDs) are categorized based on the biolog…
pubmed
Serra G, Barbera G, Antona V, Malizia D 等
2026 Jul 15
置信度 0.82
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Non-small cell lung cancer (NSCLC) comprises a diverse group of malignancies driven by distinct molecular alterations that have become critical targets for precision oncology. Among these, EGFR exon 20 insertion mutations and HER2 dysregulation, including HER2…
pubmed
Zullo L, Remon J
2026 Jul 20
置信度 0.82
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Background/Objectives : Machine learning (ML) models have increasingly been applied to prognostic prediction in oral cavity squamous cell carcinoma (OCSCC), though their performance and methodological quality remain variably reported. This systematic review ev…
pubmed
Gao SY, Hughes JM, Nguyen SA, McCaulay BS 等
2026 Jul 14
置信度 0.82
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In the published publication [...].
pubmed
Pérez M, Lozano JJ, Ingelmo-Torres M, Domenech M 等
2026 Jul 17
置信度 0.82
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Background/Objectives : Patient-derived cell lines retaining donor-specific age-related and genomic features are essential for modeling late-onset neurodegenerative disorders like Huntington's disease (HD). This study aims to establish and comprehensively char…
pubmed
Parfenova P, Kraskovskaya N, Koltsova A, Shatrova A 等
2026 Jun 30
置信度 0.82
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Congenital disorders of glycosylation (CDG) are a group of inherited metabolic diseases rapidly growing due to the discovery of new subtypes. As with many genetic conditions, their diagnosis can be challenging, impairing proper patient care and causing additio…
pubmed
Mól AR, Fontes NDC, Santos SCL, Costa E Silva C 等
2026 Jul 15
置信度 0.82
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Graft failure and graft-versus-host disease are the main limiting factors for the engraftment of not only xenogeneic but also allogeneic grafts. Long-term engraftment of human immune cells in mice with severe combined immunodeficiency and IL2rg deletion is key…
pubmed
Nagornykh AM, Tyumentseva MA, Tyumentsev AI, Fedotov LA 等
2026 Jul 14
置信度 0.82
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Reproductive characteristics in pigs exhibit low heritability levels. Performing genome-wide association studies (GWAS) to pinpoint candidate genes for these characteristics is crucial for enhancing swine fertility. In this research, hair samples were gathered…
pubmed
Zhang L, Shao J, Yang C, Ding X 等
2026 Jul 11
置信度 0.82
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SETD5 (SET domain-containing 5) is a chromatin-associated regulator increasingly recognized as dysregulated in human malignancies; however, its contribution to tumor biology and tumor-immune interactions remain undefined. We performed an integrative pan-cancer…
pubmed
Gualberto ACM, Santana BLO, de Loyola MB, da Costa YS 等
2026 Jul 21
置信度 0.82
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22q11.2 microduplication syndrome is a rare genetic disorder characterized by the presence of one or two additional copies of a segment within the 22q11.2 region of chromosome 22. While much of the literature has focused on the deletion variant leading to DiGe…
pubmed
Bisba M, Louizou E, Vittas S
2026 Jul 22
置信度 0.82
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Background: Immune modulation is central to cutaneous melanoma, and antitumor immune responses may be influenced by host genetic background. This study investigated the association between the interleukin-1β gene ( IL1B ) exon 5 synonymous single-nucleot…
pubmed
Cauci S, Buligan C, Bazzichetto L, Petris G 等
2026 Jul 9
置信度 0.82
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Background : Colorectal cancer (CRC) remains a heterogeneous disease, and improved biomarkers are needed to support prognostic assessment. This study aimed to characterize hub genes in CRC and evaluate whether a gene signature provides biologically meaningful …
pubmed
Kamal E, Moglad E, Mohager SO, Ahmed M 等
2026 Jul 8
置信度 0.82
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Circulating tumor DNA (ctDNA) has emerged as a promising minimally invasive biomarker in multiple myeloma (MM), providing dynamic insight into tumor burden, clonal evolution and molecular heterogeneity. Unlike conventional bone marrow-based diagnostics, ctDNA …
pubmed
Sretenovic A, Mitrovic M, Vukosavljevic N, Kecman N 等
2026 Jul 22
置信度 0.82
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Background and Clinical Significance : Cantú syndrome (OMIM #239850) is a rare autosomal dominant disorder caused by gain-of-function variants in ABCC9 or KCNJ8 , which encode subunits of the ATP-sensitive potassium (K ATP ) channel. Its characteristic fe…
pubmed
Lee CL, Chang YH, Chuang CK, Chiu HC 等
2026 Jul 15
置信度 0.82
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Sperm activation and movement are pivotal determinants of fertilization success in teleosts, yet the molecular mechanisms in euryhaline species remain largely unresolved. Here, we integrated physiology and multi-omics to elucidate the osmolality, ions, and reg…
pubmed
Wang Q, Zhang Y, Zhang W, Wu Y 等
2026 Jul 13
置信度 0.82
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Circadian rhythm disruptions are increasingly recognized in disorders such as obstructive sleep apnea (OSA), yet analysis of 24 h gene expression patterns remains challenging due to the lack of reliable reference genes for normalization. Even commonly used hou…
pubmed
Nahtigal K, Halužan Vasle A, Kreft T, Skubic C 等
2026 Jul 10
置信度 0.82
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The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across differen…
pubmed
Lagally L, Ullemeyer L, Omony J, Gottschau K 等
2026 Jul 27
置信度 0.82
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Long non-coding RNAs (lncRNAs) regulate gene expression, chromatin organization, and cellular signaling. Although traditionally considered non-coding, 21% of the ~190,000 annotated lncRNA transcripts contain poorly characterized open reading frames with unknow…
pubmed
Zok S, Linial M
2026 Jul 27
置信度 0.82
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Adolescents and young adults (AYA) aged 15 to 39 years with cancer have a higher prevalence of germline pathogenic variants than older patients. This study characterized the prevalence and distribution of germline pathogenic/likely pathogenic variants (GP…
pubmed
Ishioka K, Hayashi N, Miyazaki N, Dobashi A 等
2026 Jul 27
置信度 0.82
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Colorectal cancer liver metastasis (CRLM) represents the leading cause of mortality in colorectal cancer (CRC). However, the molecular mechanisms enabling metastatic adaptation within the hepatic microenvironment remain unclear. We integrated single-cell …
pubmed
Yan M, Li Y, Liu Y, Peng L 等
2026 Jul 28
置信度 0.82
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TAR DNA binding protein 43 (TDP-43), a key protein linked to ALS pathology, undergoes phase separation and forms functional assemblies via condensation within cells. The conserved region (CR) within its C-terminal domain (CTD) mediates self-assembly through he…
pubmed
Ozguney B, Puterbaugh RZ, Viswanathan R, Shenoy J 等
2026 Aug 4
置信度 0.82
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Rickettsia spp. are ubiquitous in nature and capable of causing diseases of varying severity. The most extensive group comprises the spotted fever group (SFG) Rickettsiae, the members of which are predominantly transmitted by ticks. The expansion of tick habit…
pubmed
Karmokov I, Freylikhman O, Baimova R, Grechishkina D 等
2026 Jun 27
置信度 0.82
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African swine fever (ASF) is a highly lethal disease of domestic pigs and wild suids that continues to cause substantial economic losses worldwide. Despite recent progress in live attenuated ASF vaccine development, evidence supporting durable protection under…
pubmed
Zheng X, Kim Y, Choi SA, Lee SJ 等
2026 Jun 25
置信度 0.82
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Diagnostic metabolites measured in newborn screening, inherited metabolic disease, lysosomal storage disease, oncometabolite testing and routine clinical biochemistry are direct read-outs of human metabolic state. Their mechanistic interpretation requires link…
pubmed
Goryanin I, Slovianov L, Goryanin IV, Kel A
2026 Jul 4
置信度 0.82
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Historically, the study of oral fungal species was limited by the inability to cultivate most of them. However, advances in metagenomic techniques have enabled the direct identification of microbial genomes from human samples, markedly broadening our understan…
pubmed
Cruz GMD, Fraga AS, Garcia MT, Junqueira JC
2026 Jul 17
置信度 0.82
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Endophytic fungi from Malaysian medicinal plants constitute a metabolically prolific yet underexplored reservoir for natural product discovery. This scoping review of 56 studies published between 2015 and 2025 identified a fundamental methodological divergence…
pubmed
Yang L, Phan CW, Tan YS, Sathiya Seelan JS
2026 Jul 5
置信度 0.82
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Sea cucumber Apostichopus japonicus is one of the few animals capable of synthesizing saponins, which are critical components of its nutritional quality and health-beneficial properties. However, the specific mechanism underlying saponin biosynthesis in sea cu…
pubmed
Jiang P, Gao S, Liu Y, Chen Z 等
2026 Jun 30
置信度 0.82
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Background/Objectives : Klebsiella pneumoniae complex, Escherichia coli , and Enterobacter cloacae complex are considered the most prevalent carbapenemase-producing (CP) Enterobacterales in Spain. However, temporal changes in carbapenemase distribution, clonal…
pubmed
Ugalde Zárraga E, Vidal-García M, Urrutikoetxea-Gutiérrez M, Eraso E 等
2026 Jul 22
置信度 0.82
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Immunity plays critical roles in cutaneous melanoma. We investigated the association between the pro-inflammatory interleukin-1β gene ( IL-1B ) rs16944 (-511 C > T) promoter single nucleotide polymorphism (SNP) and cutaneous melanoma susceptibility an…
pubmed
Cauci S, Buligan C, Nacci P, Petris G 等
2026 Jul 22
置信度 0.82
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The prognostic significance of next-generation sequencing (NGS) findings during the hormone-sensitive phase of prostate cancer remains incompletely characterized. This retrospective cohort study included 92 patients who underwent NGS analysis on tumor tissue b…
pubmed
Turan M, Balta MÇ
2026 Jul 10
置信度 0.82
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Ferns and angiosperms represent the two largest vascular plant lineages but exhibit striking genomic and ecological contrasts. We investigated whether differences in genome size, chromosome architecture, GC content, and stomatal traits reveal divergent evoluti…
pubmed
Bureš P, Vejvodová K, Zedek F, Elliott TL 等
2026 Jul 27
置信度 0.82
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Non-typeable Streptococcus pneumoniae (NT-Sp) strains lack detectable capsules and are often missed by traditional serotyping. While associated primarily with asymptomatic carriage, NT-Sp has emerged as a key player in antimicrobial resistance (AMR) gene disse…
pubmed
Reeks RK, Ntim OK, Donkor ES
2026 Aug
置信度 0.82
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It is estimated that 5%-10% of patients who develop breast cancer have a causative inherited pathogenic or likely pathogenic variant (P/LP variant). In 2020, the UK National Test Directory published criteria for mainstream genetic testing for breast cancer pat…
pubmed
Conroy S, Keane E, Rehman B, Wyborn E 等
2026
置信度 0.82
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Autophagic vacuoles in muscle fibers are a characteristic finding in several muscle diseases and usually indicate perturbed lysosomal protein degradation. Some of these are associated with defects in proteins directly involved in autophagy and lysosomal degrad…
pubmed
Lindgren U, Hedberg-Oldfors C, Visuttijai K, Nordström S 等
2026 Jul 26
置信度 0.82
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Patient-derived tumor organoids are widely used in cancer research, yet the biological impact of tissue processing during model generation remains unclear. Fragment-based and dissociation-based (DIS) approaches are commonly assumed to trade fidelity for unifor…
pubmed
Slovackova J, Bernatik O, Cimborova K, Barak M 等
2026 Jul 26
置信度 0.82
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We analysed 1384 newly diagnosed multiple myeloma patients from 10 representative centres of the Chinese Myeloma Committee to provide an important modern real-world reference. Survival outcomes were verified by the National Mortality Surveillance System to ens…
pubmed
Dou X, Liao A, Luo J, Li C 等
2026 Jul 26
置信度 0.82
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Direct-to-consumer (DTC) pharmacogenomic (PGx) testing is expanding rapidly in the UK, yet no dedicated regulatory framework currently governs these services. Although a 2021 parliamentary inquiry recommended stronger safeguards and clearer technical standards…
pubmed
Mathieson A, Brunton L, Gillibrand S, Moldovan R 等
2026 Jul 25
置信度 0.82
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Tobacco consumption, combined with individual genetic predispositions, contributes to an age-dependent risk not only for lung cancer but also for other non-communicable diseases (NCDs) such as cardiovascular disease (CVD), chronic obstructive pulmonary disease…
pubmed
Widłak P, Mieczkowski J, Tomasik B, Sienkiewicz K 等
2026 Jul 25
置信度 0.82
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Cladribine tablets are an oral immune reconstitution therapy with demonstrated efficacy and durable disease control in relapsing-remitting multiple sclerosis (RRMS). While global evidence supports their use, region-specific guidance adapted to healthcare varia…
pubmed
Daoudi S, Tibar H, Mhiri C, Toubal N 等
2026 Sep
置信度 0.82
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Recently identified as an emerging pathogen, tomato mottle mosaic virus (ToMMV), belonging to the Tobamovirus genus, has become a major concern for global tomato cultivation. To better understand its genetic characteristics and support future research, we inve…
pubmed
Vo TTB, Tabassum M, Nattanong B, Im HJ 等
2026 Jul 25
置信度 0.82
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Nurses contribute across the precision cancer care pathway, providing continuous, person-centred care and supporting genomic testing integration. However, the scope of nursing competencies required for precision cancer care and the extent to which current educ…
pubmed
Drury A, Sheehan S, Cunningham A, Seven M 等
2026 Aug
置信度 0.82
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Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits. Cinnamaldehyde (CA) possesses anti-inflammatory, antibacterial, and digestive-regulatory properties. However, its th…
pubmed
Yu Q, Xu B, Dai C, Pang Y 等
2025 Oct 5
置信度 0.82
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The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
pubmed
Zhu Y, Zhou JY, Zhang SY, Tang R 等
2026 Aug
置信度 0.82
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Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential.
pubmed
Zhou E, Luo S, Xiao Y, Liu B 等
2025 Jul 1
置信度 0.82
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In the current era, climate change has emerged as a fundamental threat to African agriculture, driven by increasingly erratic climatic patterns such as prolonged rainfall, decadal droughts, and escalating thermal stress. This review evaluates contemporary agri…
pubmed
Okonkwo CO, Mawcha KT, Changwa R, Ndolo D 等
2026 Aug
置信度 0.82
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Reflex testing (RT) - pathologist-initiated molecular testing performed at non-small cell lung cancer (NSCLC) diagnosis - enables rapid identification of actionable genomic alterations for targeted therapy (TT) selection. Despite national and international gui…
pubmed
Schumacher L, Kurte MS, Poos T, Thalheimer M 等
2026 Jul 24
置信度 0.82
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Neisseria gonorrhoeae is a global public health threat, exacerbated by the rapid dissemination of ceftriaxone-resistant strains harboring penA allele 60.001. Current diagnostics are limited by long turnaround times, reliance on thermal cycling equipment, and p…
pubmed
Sun X, Fu Y, Liu Y, Liu Q 等
2026 Sep
置信度 0.82
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This consensus by the CSCO Pancreatic Cancer Expert Committee establishes evidence-based guidelines for molecular testing in pancreatic ductal adenocarcinoma. It details recommendations for biomarkers (e.g., KRAS, BRCA, MSI), liquid biopsy, and precision imagi…
pubmed
Cao D, Wu J, Cui J, Xun C 等
2026 Jul 24
置信度 0.82
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Escherichia coli poses a global health threat from increasing β-lactam resistance. This study uses genomic and One Health data to map resistance patterns and enhance antimicrobial resistance (AMR) prediction and management.
pubmed
Sholeh M, Beig M, Kiani N, Badmasti F
2026 Jul 24
置信度 0.82
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Neonatal sepsis in one twin poses a dilemma in managing the healthy-appearing sibling. Shared exposures and genetic factors increase risk, and early signs of sepsis can be subtle with rapid deterioration. However, the magnitude of this risk for the healthy twi…
pubmed
Groenveld MA, Miselli F, Creti R, Buttera M 等
2026 Jul 24
置信度 0.82
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Plasmid-encoded colistin resistance mcr-1 genes are mainly reported in Escherichia coli worldwide. Here, we characterized a multidrug-resistant Klebsiella pneumoniae 70,241 clinical isolate harbouring mcr-1.1 and bla OXA-181 , recovered from a tertiary-care ho…
pubmed
Jaidane N, Fayad S, Ennaceur M, Châtre P 等
2026 Jul 24
置信度 0.82
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We report for the first time the molecular landscape and outcome associations from the prospective CLIMEDIN trial in Greece.
pubmed
Kosmidis PA, Kosmidis T, Papadopoulou K, Korfiatis N 等
2026
置信度 0.82
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Randomized controlled trials remain fundamental to evidence generation in oncology but are increasingly complex, costly, and often misaligned with real-world practice. Traditional explanatory trials, designed under ideal, controlled conditions, frequently enro…
pubmed
Madariaga A, Veneziani A, Bookman M, Counsell N 等
2026 Jun 23
置信度 0.82
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The subtyping of breast carcinoma (BC) is essential for an accurate diagnosis, prognosis, and treatment decisions. Histopathological evaluation and immunohistochemical analysis are standard methods for clinical stratification of patients with BC. Gene expressi…
pubmed
Alexovič M, Sabo J, Bouchal P
2026 Aug
置信度 0.82
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An ongoing measles outbreak in Israel, involving ≈3,200 cases and 16 deaths, threatens the country's measles elimination status and reflects declining vaccination rates observed globally and within Israel. Epidemiologic investigations supported by seque…
pubmed
Bucris E, Zuckerman NS, Levin T, Kanaaneh Y 等
2026 Sep
置信度 0.82
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We report six human Dermatophilus infections diagnosed in Basel between May 2025 and March 2026. The travel-associated first case developed a pustular rash and conjunctivitis after a stay in Thailand. A second imported case occurred after travel to Indonesia. …
pubmed
Keller PM, Di Nicola R, Marković L, Köster M 等
2026 Jul
置信度 0.82
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Neuropaediatric Rare Diseases (NRDs) impose a profound and multidimensional burden on patients, families, and healthcare systems. Persistently low clinical trial success rates reflect an unmet methodological need as much as a therapeutic one. A fundamental bot…
pubmed
Acosta MT, Aibar JÁ, Arango C, Cirauqui EA 等
2026
置信度 0.82
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Germline genetic testing is integral to precision oncology in prostate cancer (PCa), particularly for men with pathogenic or likely pathogenic (P/LP) BRCA1/2 variants, where results have therapeutic and hereditary implications. However, data from the Middle Ea…
pubmed
van Wyk C, Abdulrahim R, Crous I, Al Saegh A 等
2026
置信度 0.82
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Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting toxicity of cancer treatment, yet reliable biomarkers to predict individual susceptibility remain lacking. Germline genetic variation has been widely investigated as a potential contr…
pubmed
Maganti A, Rankothge I, Sakadales H, Kok E 等
2026
置信度 0.82
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In 2019, a marine pestivirus, Phocoena pestivirus (PhoPeV), family Pestiviridae, was described for the first time. To date, the impact of PhoPeV infections on harbor porpoises is still unknown. Therefore, a screening study was carried out on harbor porpoises f…
pubmed
Söder L, Meyer D, Gremmel N, Postel A 等
2026
置信度 0.82
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This study evaluated the effects of dietary guanidinoacetic acid (GAA) supplementation (0.06%) at different feeding phases on growth performance, carcass traits, plasma biochemistry, meat quality and hepatic transcriptomic responses in broiler chickens under h…
pubmed
Irawan A, Saraswati PN, Saputro WS, Darmawan MA 等
2026 Jul 23
置信度 0.82