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• Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis
  crossref Charlie Marvalim, Dedrick Kok Hong Chan 2025-12-15T02:04:18Z 置信度 0.70
• Navigating gene editing in porcine embryos: Methods, challenges, and future perspectives
  crossref Julieta G. Hamze, Josep M. Cambra, Sergio Navarro-Serna, Cristina A. Martinez-Serrano 2025-02-13T03:03:59Z 置信度 0.70
• The Aloe Genome
  crossref Vinod Chhokar, Alka Jangra 2025-12-08T09:14:24Z 置信度 0.70
• MARSweb: a fully automated web service for set-based association testing
  crossref Taegun Kim, Jaeseung Song, Jong Wha J. Joo 2025-02-24T15:37:47Z 置信度 0.70
• Genetic insights into 5-LOX-activating protein: a narrative review of disease associations
  Abstract The 5-lipoxygenase-activating protein (FLAP) is an integral membrane protein that is essential for 5-lipoxygenase-mediated leukotriene formation, thereby playing a key role in inflammation and serving as a potential therapeutic target. For over 30 yea…
  crossref Katharina Rataj, Ulrike Garscha 2025-12-13T08:57:25Z 置信度 0.70
• Correction: De novo and inherited variants in coding and regulatory regions in genetic cardiomyopathies
  crossref Nirmal Vadgama, Mohamed Ameen, Laksshman Sundaram, Sadhana Gaddam 等 2025-10-24T09:12:54Z 置信度 0.70
• Comprehensive pan-cancer analysis of HSPG2 as a marker for prognosis
  crossref Fangjun Chen, Xing Gu, Guangliang Qiang 2025-02-17T02:57:02Z 置信度 0.70
• Molecular identification and phylogenetics analysis of southern Indian Amaranthus L. using chloroplast barcodes
  crossref Pinke Cherian, Stalin Nithaniyal, Prabhu Srinivasan 2025-01-22T16:47:03Z 置信度 0.70
• The chromosomal challenge of human embryos: Mechanisms and fundamentals
  crossref Anna Ivanova, Elena Korchivaia, Maria Semenova, Igor Lebedev 等 2025-04-10T03:34:09Z 置信度 0.70
• The fine art of chromatin folding: Revealing the path of DNA inside mitotic chromosomes
  crossref Marina Vitoria Gomes, Christian H. Haering 2025-06-11T14:48:51Z 置信度 0.70
• Evolutionary dynamics of the proanthocyanidin biosynthesis gene LAR
  Abstract Background Leucoanthocyanidin reductase (LAR) is a key enzyme in proanthocyanidin (PAs) biosynthesis, catalyzing the conversion of leucoanthocyanidins to catechins. While early steps in the flavonoid pathway are broadly conserved across plant lineages…
  crossref Maria F. Marin-Recinos, Boas Pucker 2025-12-19T12:34:46Z 置信度 0.70
• The CRISPR-Cas revolution in head and neck cancer: a new era of targeted therapy
  crossref Mohsen Hashemi, Xaniar Mohmmadi Khanaghah, Javid Sadri Nahand 2025-05-30T07:43:20Z 置信度 0.70
• Crystal Structure of Tryptophanyl-tRNA synthetase from Klebsiella aerogenes
  crossref 2025-04-22T17:42:11Z 置信度 0.70
• MEIS1 knockdown upregulates WNT signaling pathway genes in esophageal squamous cell carcinoma
  crossref Nayyerehalsadat Hosseini, Mohammad Mahdi Forghanifard 2025-04-10T05:59:56Z 置信度 0.70
• Benchmarking foundation cell models for post-perturbation RNA-seq prediction
  Abstract Accurately predicting cellular responses to perturbations is essential for understanding cell behaviour in both healthy and diseased states. While perturbation data is ideal for building such predictive models, its availability is considerably lower t…
  crossref Gerold Csendes, Gema Sanz, Kristóf Z. Szalay, Bence Szalai 2025-04-23T08:19:08Z 置信度 0.70
• Divergent genetic diversity reveals contrasting demographic histories in two commercially important snappers
  crossref Achmad Zamroni, Muhammad Taufik, Tri Ernawati, Erfind Nurdin 等 2025-10-07T00:39:24Z 置信度 0.70
• Black pepper knowledge base (BlackPepKB): a centralized web resource for functional genomics of black pepper (Piper nigrum L.)
  crossref L. M. D. Bawanga, D. R. R. Wijewardene, Praveena Sarathchandra, S. Viswakula 等 2025-10-17T11:51:32Z 置信度 0.70
• Role of Deep Learning Algorithms in Next-Generation Human Genomics Sequencing
  crossref Pawan Kumar, Anu Chaudhary, Mandeep Singh, Shashank Sahu 2025-09-30T09:44:27Z 置信度 0.70
• Molecular mechanisms of air pollution–induced carcinogenesis and the emerging role of microplastics
  Abstract Ambient air pollution is a major environmental carcinogen consisting of a complex mixture of particulate matter, gases, and adsorbed toxicants. Fine (PM 2.5 ) and ultrafine (PM 0.1 ) particles are of particular concern due to their capacity to penetra…
  crossref Julia Vu, Kari Nadeau, Maya Kasowski 2025-12-04T13:14:38Z 置信度 0.70
• Psychometric Properties of a Culturally Adapted Spanish Version of the Attitudes toward Genomics and Precision Medicine Instrument
  Introduction: There is evidence of growing racial and ethnic disparities in genomic healthcare and precision medicine. Validated survey instruments and measures are required to understand the needs of diverse populations to appropriately tailor person-centered…
  crossref Ella Anghel, María Pineros-Leano, Isabella R. McDonald, Andrew A. Dwyer 2025-04-26T16:01:33Z 置信度 0.70
• Prolonged obesity alters males’ adipose profile: implications for disease?
  crossref Jessica L. Faulkner 2025-02-18T18:19:42Z 置信度 0.70
• Revisiting variation in the somatic mutation landscape of non-small cell lung cancer
  crossref Vaibhavi Pathak, Koichi Tazaki, Minal Çalışkan 2025-02-24T11:40:15Z 置信度 0.70
• Human gut microbiome determining athletes’ performance: An insight from genomic analysis
  crossref Shih Chung Cheng, Chieh Chang, Yen-Cheng Chen, Takashi Gojobori 等 2025-01-09T17:53:18Z 置信度 0.70
• Acknowledgment
  crossref Javid Ahmad Parray, PIFI–CAS Fellow 2025-02-28T15:32:14Z 置信度 0.70
• Nonmedical drug use and suicidal ideation among adolescents in the Republic of Korea: a population-based study.
  Nonmedical drug use (NMU) among adolescents is an emerging public-health concern; however, population-based evidence on its association with suicidal ideation in the Republic of Korea remains limited. Using pooled data from the 2022-2024 Korea Youth Risk Behav…
  pubmed Park JK, Lee J, Lee SJ 2026 Jul 19 置信度 0.82
• Accurate, sensitive, and efficient chromatin accessibility quantification at target loci using UNIChro-seq.
  Recent progress in statistical and experimental fine mapping of disease risk variants prompts us to focus on specific target loci for functional investigation. However, current genetics is hindered by a limited toolbox for target-loci analysis. To address this…
  pubmed Kono M, Hatano H, Asahara K, Nakano M 等 2026 Jul 20 置信度 0.82
• Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.
  Borderline personality disorder (BPD) is a severe mental health condition influenced by environmental risk factors (for example, interpersonal trauma) and genetic factors. We conducted the largest genome-wide association study (GWAS) meta-analysis of BPD so fa…
  pubmed Streit F, Awasthi S, Hall ASM, Braun A 等 2026 Aug 置信度 0.82
• Advancing neonatal care through standardized lung ultrasound implementation.
  To evaluate the impact of standardized lung ultrasound (LUS) implementation in neonatal intensive care.
  pubmed Dauengauer-Kirliene S, Jakumas G, Gunter LL, Prunskiene H 等 2026 Jul 置信度 0.82
• The WinPro trial: window-of-opportunity study of endocrine therapy with micronised progesterone in ER-positive breast cancer.
  Progesterone can inhibit tumoural proliferation in oestrogen receptor positive (ER+) breast cancer. The WinPro trial (Australian New Zealand Trials Clinical Trials Registry number: ACTRN12618000928213, date of registration 01/06/2018) was a randomised, multi-c…
  pubmed Haggstrom L, Middleton K, Parker A, Segara D 等 2026 Jul 21 置信度 0.82
• Household Transmission of SARS-CoV-2 in Washington and Oregon, United States, 2022-2024.
  Households remain high-risk settings for SARS-CoV-2 transmission. Identifying contemporaneous risk factors for infection among household contacts of an index case can guide public health strategies.
  pubmed Babu TM, Casto A, Hollcroft M, Hoffman KL 等 2026 Aug 4 置信度 0.82
• Sex-Specific Cardiovascular Phenotypes in Marfan Syndrome.
  Marfan syndrome (MFS) is a heritable connective tissue disorder in which cardiovascular complications drive morbidity. Contemporary sex-based differences in vascular and rhythm manifestations remain incompletely defined.
  pubmed Dreher L, Abdul Nabi H, VanDolah HB, Hartnett J 等 2026 Aug 置信度 0.82
• Comprehensive genomic characterization of herpes B virus isolated from a wild long-tailed macaque reveals conserved entry mechanisms and zoonotic potential.
  Herpes B virus (BV; Macacine alphaherpesvirus 1 ) is a zoonotic alphaherpesvirus endemic in macaques that can cause severe, often fatal encephalomyelitis in humans. However, genomic data from wild macaque populations remain limited. Here, we report the isolati…
  pubmed Paungpin W, Chaiwattanarungruengpaisan S, Thongdee M, Sariya L 等 2026 Dec 置信度 0.82
• Influence of genomic retained heterosis on lactation persistence and tropical resilience: leveraging joint-model GWAS to quantify non-additive variance in India's Karan Fries population.
  The Karan Fries (KF), a newly developed dairy cattle (Holstein Friesian × Tharparkar), after nine generations of inter se mating (mating among crossbreds) by maintaining a stable, composite breed structure, is expected to preserve some heterosis or hybrid…
  pubmed Kumar I, Vyas J, Khan A, Ramola G 等 2026 Jul 20 置信度 0.82
• Home blood pressure telemonitoring reveals race-specific patterns of target organ damage.
  Racial differences in cardiac and renal target organ damage (TOD) may persist at comparable blood pressure levels. This study compared TOD in high-risk, non-African-American Black and White patients in relation to the home blood pressure (HBP).
  pubmed Zhang DY, An DW, Yu YL, Kaleta BP 等 2026 Sep 1 置信度 0.82
• The Evolving Landscape of Monkeypox: From Endemic Pathogen to Global Threat.
  Monkeypox (mpox) is a reemerging viral zoonosis caused by the mpox virus (MPXV) that has significant global public health implications following the 2022 and 2024 outbreaks. This review examines the evolving landscape of MPXV, focusing on its genomic organizat…
  pubmed Bhimwal T, Aaquib M, Yadav M, Goyal T 等 2026 Jul 20 置信度 0.82
• METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery.
  METTL1, in complex with its partner protein WDR4, is the principal writer of internal and RNA-associated N7-methylguanosine (m7G), an epitranscriptomic modification that remodels translation, RNA stability, and stress-response pathways. Across diverse cancer t…
  pubmed Fabbrizi E, Hailu GS, Mancini A, Mai A 等 2026 Aug 13 置信度 0.82
• Combined Time-Restricted Feeding and Physical Exercise Attenuate ER Stress and Improve Liver Inflammation and Collagen Deposition in Aged Mice.
  Aging is associated with progressive impairment of hepatic adaptive capacity, including mitochondrial dysfunction, oxidative stress, and disruption of proteostasis. Persistent activation of the unfolded protein response (UPR), particularly under chronic endopl…
  pubmed Antonio GCF, Pitoli BS, Macêdo APA, de Lima RD 等 2026 Jul 置信度 0.82
• Time Lost Is Brain Lost: Insights into Acute Ischaemic Stroke Delays in a Tertiary Care Super-speciality Centre in Jharkhand.
  Early hospital arrival is essential for timely thrombolysis in acute ischaemic stroke. However, many patients in low-resource settings continue to reach tertiary care centres beyond the recommended treatment window.
  pubmed Kumari T, Sinha Y, Kumar A, Prasad A 等 2026 Jul 18 置信度 0.82
• Microbial diversity and functional analysis in wastewater and sludge of wastewater treatment plants.
  The efficiency of wastewater treatment plants (WWTPs) relies heavily on microbial communities. However, the microbial characteristics of different treatment units in the Qian'an WWTP (Hebei, China) remain unclear. This study investigates its microbial diversit…
  pubmed Li Y, Zhang S, Xu K, Zhang J 等 2026 置信度 0.82
• Global Bibliometric and Phylogenetic Analysis of mcr-Mediated Colistin Resistance.
  The emergence and spread of mobilized colistin resistance (mcr) genes threaten the efficacy of colistin, a last-resort antibiotic used in the management of multidrug-resistant Gram-negative bacteria (GNB). This study was aimed at (1) providing a bibliometric a…
  pubmed Ali MZ, Edet UO, Theodore UC, Nwaokorie F 等 2026 置信度 0.82
• Molecular characterization and recent spread of dengue virus type 3 lineage III_B.3.2 in Brazil: in silico analysis of protein motifs and epidemiology.
  The dengue virus (DENV) belongs to the Flaviviridae family and is responsible for a febrile arbovirus disease of global relevance. In Brazil, there has been endemic circulation of the four viral serotypes since the last century, with DENV-3 being frequently as…
  pubmed de Morais AP, Oliveira RC 2026 Jul 19 置信度 0.82
• Bioinformatics reveals the prognostic potential of manganese metabolism-related genes in lung adenocarcinoma.
  Manganese metabolism may be involved in the malignant progression of lung adenocarcinoma (LUAD). Clarifying the roles of manganese metabolism-related genes (MMRGs) in LUAD may provide potential therapeutic targets for LUAD treatment. Mendelian randomization an…
  pubmed Zha J, Liu X, Gao S, He J 等 2026 Jul 20 置信度 0.82
• Outbreak of Dengue fever in Edo State, South-South, Nigeria: Case Series.
  Dengue fever (DF) remains an emerging but underrecognized public health threat in Nigeria, often misdiagnosed as malaria or other acute febrile illnesses due to overlapping symptoms. This case series documents the first clinically and laboratory-confirmed outb…
  pubmed Ayanwale S, Ojeifo SB, Owoicho S, Awosanya E 等 2025 Sep-Oct 置信度 0.82
• Clinical spectrum and ascertainment pathways in pediatric female dystrophinopathy.
  Pediatric female dystrophinopathy may be asymptomatic at evaluation or may show skeletal muscle and cardiac manifestations, but childhood presentations are often subtle. We aimed to characterize the clinical spectrum, ascertainment pathways, subclinical muscle…
  pubmed Jiao H, Bai J, Li P, Sun J 等 2026 Jul 18 置信度 0.82
• Genetic diversity of West Nile virus lineage 2a circulating in Culex pipiens vector populations from Bucharest city during the 2024 and 2025 transmission seasons.
  West Nile virus (WNV) is an emerging pathogen in Europe with an unprecedented northward expansion. In Romania, the virus has been endemic for at least three decades, and human infection cases are registered yearly, sometimes culminating in outbreak events. Buc…
  pubmed Dinu S, Prioteasa FL, Pintiliescu A, Albu OC 等 2026 Jul 18 置信度 0.82
• Seroprevalence, associated risk factors, and molecular detection of Brucella spp. in cattle, sheep, goats and humans in Mvomero district, Morogoro, Tanzania.
  Brucellosis is a zoonotic disease of public health and economic importance worldwide. A cross-sectional study using simple random and purposive sampling techniques was conducted from May 2024 to October 2024 in agro-pastoral areas of Mvomero district, Morogoro…
  pubmed Lita EP, Mkupasi EM, Ochi EB, Misinzo G 等 2026 Jul 19 置信度 0.82
• Combined transcriptomics and metabolomics reveals the molecular mechanism by which rice responds to Ustilaginoidea virens infection.
  Rice false smut caused by Ustilaginoidea virens is a major fungal disease of rice in rice-growing regions throughout the world. However, the key genes and key metabolites related to U. virens resistance in rice remain unclear. Here, we used transcriptomics and…
  pubmed Fu R, Li H, Luo X, Wang J 等 2026 Jul 18 置信度 0.82
• Integrated transcriptomic and metabolomic analyses identify OsCGT as essential for C-glycosyl flavone biosynthesis in OsDET1-mutant rice seeds.
  C-glycosyl flavones rarely accumulate at high levels in rice seeds, and the genetic basis underlying their biosynthesis and regulation remains poorly understood. The rice yel-sdj mutant, carrying a mutation in DE-ETIOLATED 1 (OsDET1), shows elevated accumulati…
  pubmed Kim B, Choi HJ, Shim S, Jang SG 等 2026 Jul 18 置信度 0.82
• First site-specific N-glycoproteome of the spider mite Tetranychus urticae reveals a glycan signature different from insect models and functional insights for pest management.
  Protein N-glycosylation is a fundamental post-translational modification that shapes protein folding, stability, trafficking, and biological function. In arthropods, current understanding of N-glycosylation is largely derived from insect models, whereas chelic…
  pubmed Liu D, Smagghe G 2026 Jul 18 置信度 0.82
• FKBP10 may affect the malignant phenotype of oral squamous cell carcinoma cells through the ECM/WNT signaling pathway.
  Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region with a poor prognosis, and its pathophysiology has not been fully elucidated. Although FKBP10 is overexpressed in multiple malignancies, its function and regul…
  pubmed Shen C, Hou R, Zhang J, Zhang Q 等 2026 Jul 18 置信度 0.82
• Molecular typing of PVL-positive Staphylococcus aureus isolates from Lithuania and genome sequencing of a local outbreak strain.
  Staphylococcus aureus is a major human commensal and pathogen, with the Panton-Valentine leukocidin (PVL) genes being associated with increased virulence. Rapid detection and molecular typing of such isolates are essential for effective epidemiological surveil…
  pubmed Monecke S, Müller E, Kirkliauskienė A, Schneider LJB 等 2026 Jul 18 置信度 0.82
• Clinical characteristics, outcomes and molecular epidemiology of group B streptococcal disease in young infants in the Netherlands.
  Group B streptococcus (GBS) disease remains a major cause of morbidity and mortality in young infants. We conducted a prospective multi-centre cohort study to evaluate clinical outcomes, molecular epidemiology, and coverage of potential maternal vaccines candi…
  pubmed Groenveld MA, Visser DH, Brouwer MC, Jamrozy D 等 2026 Jul 18 置信度 0.82
• Impact of SARS-CoV-2 variants and demographic factors on COVID-19 severity in pediatric patients.
  Factors that influence pediatric COVID-19 severity remain incompletely understood, particularly related to the impact of viral and host factors. Understanding the factors contributing to the severity of presentation can impact clinical approaches and managemen…
  pubmed Barter TT, Ostrow D, Weaver C, Wood JC 等 2026 Jul 17 置信度 0.82
• Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study.
  Few studies have characterized immune correlates of SARS-CoV-2 infection risk in children, particularly those with hybrid immunity from vaccination and prior infection. We conduct a prospective community-based cohort study of 1509 U.S. children (2022-2024), pe…
  pubmed Hoffman KL, Marshall G, Frivold C, Acker Z 等 2026 Jul 18 置信度 0.82
• Pulmonary Delivery of Self-Amplifying RNA: Balancing Inflammation and Durable Transgene Expression.
  Self-amplifying mRNA (saRNA) is emerging as a leading platform for both vaccination and gene therapy. However, saRNA and the lipid nanoparticles (LNPs) used for their delivery activate the innate immune system, which may complicate pulmonary delivery of saRNA-…
  pubmed Sun Q, Cui X, Li H, Vervaeke P 等 2026 Aug 4 置信度 0.82
• Decoding apoptosis, ferroptosis, and inflammatory cell death in adenomyosis at single-cell resolution.
  Accurate pathway activity inference from single-cell RNA sequencing (scRNA-seq) data is hindered by sparsity, technical noise, and the weak yet coordinated nature of transcriptional programs. Existing methods typically aggregate expression values over predefin…
  pubmed Sheng Q, Wu Q, Fan J, Sangaraju VK 等 2026 Jul 3 置信度 0.82
• Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7.
  The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), driving Aβ accumulation, tau pathology, and synaptic dysfunction. Allele-specific correction of APOE4 represents a promising therapeutic stra…
  pubmed Kim Y, Lee G, An S, Park H 等 2026 Jul 17 置信度 0.82
• Symposium on evacuation and shelter-in-place strategies in nuclear disasters: preventing disaster-related deaths.
  On 27 September 2024, at the 67th Annual Meeting of the Japan Radiation Research Society at the Kitakyushu International Conference Center in Kokura City, the program organizers held a symposium titled 'Symposium on Evacuation and Shelter-in-place Strategies i…
  pubmed Matsumoto C, Sawano T, Murakami M, Takahara S 等 2026 Jul 24 置信度 0.82
• Mapping ovarian cellular and molecular landscape across the lifespan of women: a scoping review.
  With growing interest in ART, fertility preservation, and postmenopausal health of women, reproductive medicine is increasingly focused on characterizing oocytes and ovarian tissue composition, as well as understanding the molecular mechanisms that guide ovari…
  pubmed Obukhova D, Loid M, Schor M, Brunner HG 等 2026 Jul 17 置信度 0.82
• Characterization of bovine-derived H5N1 viruses expressing fluorescent and luminescent reporter proteins.
  Highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses present a broad host range, with recent spillover and sustained transmission in dairy cattle reported in the USA. Replication-competent reporter viruses are critical tools that enable real-time moni…
  pubmed Nooruzzaman M, Britto de Oliveira PS, Feng C, Diel DG 2026 Jul 置信度 0.82
• Potential association of genetic variants with thoracic aortic aneurysm and dissection: Evidence from a Japanese community-based cohort.
  Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition for which early risk stratification and preventive strategies present critical challenges. Although genetic contributions are well established in high-risk populations, the clinical…
  pubmed Akabane K, Nakamura K, Sato H, Konta T 等 2026 Jul 17 置信度 0.82
• Development of a novel rapid genome exponential amplification reaction (GEAR) assay for high-sensitivity detection of Campylobacter coli using simplified sample preparation for on-site detection.
  Campylobacter coli is a major zoonotic foodborne pathogen, but its detection through conventional culture-based methods is challenged by intricate taxonomy, fastidious growth requirements, and auxotrophic characteristics. Prompt and precise detection of C. col…
  pubmed Milton AAP, Hussain Z, Mech MM, Srinivas K 等 2026 Jul 17 置信度 0.82
• Severe pneumonia and acute respiratory distress syndrome caused by avian influenza A (H10N3) in a young female: a case report.
  Human infection with avian influenza A (H10N3) is a rare but severe emerging zoonotic disease. To date, only a limited number of cases have been reported, which restricts a comprehensive understanding of its clinical features and public health risks. We report…
  pubmed Zhao M, Shi Q, Zhao L, Wang M 等 2026 Jul 17 置信度 0.82
• Genome-wide investigation of outbreak-associated Vibrio cholerae in Gujarat, India identifies antimicrobial resistance genes, virulence determinants, and mobile genetic elements.
  This study investigates the 2024 cholera outbreak in Gujarat, India, utilizing combined whole-genome analysis of clinical Vibrio cholerae isolates and wastewater surveillance. A total of, 69 V. cholerae isolates were recovered from affected patients, predomina…
  pubmed Bhure M, Shukla N, Purohit H, Patel N 等 2026 置信度 0.82
• Comparative evaluation of the activity of novel β-lactam antibiotics against difficult-to-treat Pseudomonas aeruginosa clinical isolates.
  This study aimed to characterize susceptibility profiles of both currently approved and investigational β-lactam agents against difficult-to-treat resistant Pseudomonas aeruginosa (DTR P. aeruginosa ) clinical isolates, including carbapenemase-producing …
  pubmed Mystakelis H, Shields RK, Mathers AJ, Bergman Y 等 2026 Aug 置信度 0.82
• DNA Methylation and Proteomic Profiling of Postmortem Brain Tissue Reveals Epigenetic Dysregulation and Neuroinflammatory in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS).
  Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by FMR1 premutation CGG repeat expansions (55-200 repeats). The epigenetic landscape of the FXTAS brain remains uncharacterized. We performed genome-wide DNA …
  pubmed Lozano R, Lin X, Hagerman R, Cerdeño VM 等 2026 Jul 10 置信度 0.82
• ClGAI-LIKE-ClPrx53 module regulates waterlogging-induced shoot elongation in watermelon.
  Waterlogging is a major abiotic stress that severely constrains plant growth and development. While studies on waterlogging tolerance have predominantly focused on wetland plants, the molecular adaptation mechanisms in xerophytes remain largely unexplored. Wat…
  pubmed Guan X, Wang Y, Xu T, Lei A 等 2026 Jul 16 置信度 0.82
• Study protocol of the C-SOLVE (JACCRO GC-12) trial; a randomized, non-comparative phase II trial of CapeOX or SOX plus zolbetuximab in HER2-negative, CLDN18.2-positive unresectable advanced gastric or esophagogastric junction cancer.
  Capecitabine + oxaliplatin (CapeOX) + zolbetuximab and 5-FU + oxaliplatin (mFOLFOX6) + zolbetuximab are recommended as first-line treatments for chemotherapy-naïve patients with HER2-negative, CLDN18.2-positive advanced gastric…
  pubmed Yuki S, Kawakami H, Harada K, Kubota Y 等 2026 Jul 17 置信度 0.82
• Spatially resolved proteomics provides insights into the normal-dysplasia-tumor continuum in oral squamous cell carcinoma.
  Oral epithelial dysplasia is a recognized precursor lesion for oral squamous cell carcinoma (OSCC), yet the proteomic changes underlying the progression from normal epithelium to dysplasia and ultimately to OSCC remain incompletely characterized. This gap is p…
  pubmed Peng C, Cai X, Huang M, Zhai Y 等 2026 Jul 16 置信度 0.82
• Comprehensive clinical and genomic analysis of early onset cancer of the bladder and upper urinary tract.
  Urothelial cancer typically affects older adults, yet early-onset urothelial cancer (EO-UC, age ≤ 45 years) cases are rising and remain poorly characterized. We hypothesized that EO-UC exhibits distinct clinical and genomic features that reflect a diffe…
  pubmed Truong H, Eichholz J, White C, Ostrovnaya I 等 2026 Jul 16 置信度 0.82
• Microbial functions in skin inflammation: a Mendelian randomization study.
  Inflammatory skin diseases (ISDs) represent a significant global health burden, yet the role of the human microbiome in their pathogenesis remains unclear. This study employed a comprehensive two-sample Mendelian randomization (MR) framework to investigate pot…
  pubmed Yang Y, Zhong Y, Wu P, Li M 等 2026 Jul 16 置信度 0.82
• Integrative analysis identifies ALDOA and PGK1 as prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma.
  Oral squamous cell carcinoma (OSCC) is associated with high mortality and limited effective targeted therapies. Although metabolic reprogramming is closely linked to malignancy, the key metabolic regulators that functionally drive OSCC progression and may serv…
  pubmed Kang W, Hou Y, Xiang L, Wang L 等 2026 Jul 16 置信度 0.82
• Craticula vanensis sp. nov., a new species of diatom with a complex mitogenome, inhabiting soda lakes in central Europe and Anatolia.
  This article formally describes Craticula vanensis sp. nov., a new species of diatom from Lake Van, the largest soda lake in the world, and the fifth new species identified in the lake following an 81-years gap in investigations. A genomic approach based on sh…
  pubmed Yılmaz E, Gastineau R, Górecka E, Solak CN 等 2026 Jul 16 置信度 0.82
• Genomic analysis of Campylobacter risk in retail chicken isolated from Beijing in 2024.
  This study investigated the prevalence, genetic diversity, antimicrobial resistance, and virulence characteristics of Campylobacter spp. isolated from retail chicken carcasses in Beijing, China. Overall, Campylobacter was detected in 55.88% of samples, with si…
  pubmed Zhao J, Liu Y, Li M, Zheng R 等 2026 Nov 2 置信度 0.82
• Clinical and genetic characteristics of pediatric hereditary spastic paraplegia in the Eastern Levant.
  Hereditary spastic paraplegia (HSP) comprises a heterogeneous group of inherited neurodegenerative disorders characterized by progressive spasticity and weakness primarily of the lower extremities. Data describing pediatric HSP from the Levant region remain li…
  pubmed Habanjar D, Kreidly S, Trad S, Boustany RM 2026 Jul 置信度 0.82
• Age-related distribution of homologous recombination deficiency in advanced ovarian carcinoma: a large real-world French cohort.
  Tumor genetic testing for BRCA and homologous recombination repair is essential for guiding maintenance therapy in high-grade non-mucinous ovarian carcinomas. While clinical trials (PAOLA-1, PRIMA, ATHENA-MONO, PRIME) have reported homologous recombination def…
  pubmed Gertych W, Trecourt A, Morineau F, Beacco P 等 2026 Jun 23 置信度 0.82
• Epidemiological and genomic analysis of the dengue virus isolate from Jeddah, Saudi Arabia: Implications for future therapeutic development.
  Dengue fever is one of the major mosquito-borne diseases worldwide, and studies have shown that more than half of the world population could be at risk of dengue in the future. To date, there are no universally effective vaccines or specific antiviral treatmen…
  pubmed Damfo S, Zaki EA, Marouf MY, Alghamdi MA 等 2026 置信度 0.82
• Increase in Disseminated Gonococcal Infections - Alaska, 2023-2024.
  Disseminated gonococcal infection (DGI) is a rare but serious complication of Neisseria gonorrhoeae infection that can result in severe illness or death. In April 2024, the Alaska Section of Epidemiology (SOE) identified an increase in suspected DGI cases in A…
  pubmed Rogers JH, Ohlsen E, Stump JC, Joseph SJ 等 2026 Jul 16 置信度 0.82
• Genotype-Specific Detection of Measles Virus Using Wastewater Surveillance - Wisconsin, February 2026.
  In February 2026, two travel-associated cases of measles were reported to the Wisconsin Department of Health Services (WDHS). Public health investigations for each case included wastewater (sewage) surveillance for wild-type measles, which was first implemente…
  pubmed Pray I, Roguet A, Dutcher HA, Schauer S 等 2026 Jul 16 置信度 0.82
• Human Umbilical Cord Mesenchymal Stem Cells in Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) Therapy: Mechanisms, Clinical Efficacy, and Future Perspectives.
  There is currently no approved drug treatment for metabolic dysfunction-related fatty liver disease (MAFLD). Umbilical cord-derived mesenchymal stem cells (UC-MSCs) show therapeutic potential, but their mechanism of action is remains incompletely understood. D…
  pubmed Jiang H, Wang H, Zhu Y, Yi C 等 2026 Jul 16 置信度 0.82
• Increased genotoxicity in human corneal epithelial cells associated with keratoconus.
  The corneal epithelium is a biologically active tissue that helps maintain corneal homeostasis through continuous interaction with the underlying stroma. While oxidative stress-related DNA damage has been implicated in corneal disease, direct experimental evid…
  pubmed Yiğit ME, Çetinkaya S, Özge G, Erdem O 等 2026 Jul 16 置信度 0.82
• De novo Transcriptome Assembly of the Venom Gland of Conus inscriptus Provides Insights into its Conotoxin Repertoire.
  Cone snails (Conus spp.) produce complex venoms rich in conotoxins, a diverse group of cysteine-rich peptides with high specificity toward ion channels, receptors, and transporters, making them valuable candidates for drug discovery. Despite the pharmacologica…
  pubmed Raju K, Kathirvelpandian A, Sudhagar A, Murali S 等 2026 Jul 16 置信度 0.82
• First molecular detection of porcine parvovirus 5 in slaughtered pigs from Southern Vietnam.
  Porcine parvovirus 5 (PPV5) has been increasingly reported in swine populations in several countries, but no molecular evidence of this virus has been documented in Vietnam. This study investigated the molecular positivity rate of PPV5 in slaughtered pigs from…
  pubmed Nguyen TT, Nguyen DTT, Tran DQ, Nguyen DT 等 2026 Jul 16 置信度 0.82
• Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2).
  Mutations that enhance type I interferon (IFN-I) activity cause monogenic autoinflammatory disorders termed type I interferonopathies. Along with the typical neurologic and rheumatologic manifestations, severe pulmonary disease is increasingly recognized yet p…
  pubmed Gruber C, Ramba M, Debnath B, Cuollo L 等 2026 Aug 3 置信度 0.82
• Whole-genome sequencing analysis of clinical carbapenemase-producing bacteria isolated in Dakar, Senegal.
  Antimicrobial resistance, particularly to carbapenems, represents a major global public health threat. In Senegal, the increasing prevalence of carbapenem-resistant Gram-negative bacilli compromises the management of severe infections. This study, conducted be…
  pubmed Ibrahim M, Ibrahima Lo C, Diallo F, Dossouvi KM 等 2026 Aug 4 置信度 0.82
• Molecular determinants of antimicrobial resistance in Klebsiella pneumoniae isolates among geriatric patients in Chattogram, Bangladesh: a cross-sectional study.
  Klebsiella pneumoniae (KPN) infections pose heightened risks in the geriatric population due to weakened immunity, prevalent comorbidities, potential exposure in long-term care settings, and increased likelihood of antibiotic resistance (ABR). The study focuse…
  pubmed Arif MH, Tanni AA, Yasmin F, Karim MN 等 2026 Aug 4 置信度 0.82
• Alarming levels of fluoroquinolone resistance among MDR-TB patients in Poland: molecular and phenotypic analysis.
  Fluoroquinolones (FQs) are a cornerstone of modern multidrug-resistant tuberculosis (MDR-TB) treatment, particularly within the WHO-recommended all-oral BPaLM regimen. The emergence of FQ-resistant Mycobacterium tuberculosis (MTB) poses a critical threat to th…
  pubmed Kozińska M, Głogowska A, Minias A, Dziadek J 等 2026 置信度 0.82
• Genomic epidemiology and antimicrobial susceptibility of clinical Mycoplasma pneumoniae isolates in Shanghai, 2023-2024.
  Mycoplasma pneumoniae ( M. pneumoniae ) is a leading cause of respiratory infection in school-age children. A global resurgence occurred in 2023-2024, yet whole-genome molecular epidemiology and antimicrobial susceptibility data remains limited.
  pubmed Wu Q, Pan F, Wang N, Yu F 等 2026 置信度 0.82
• Multi-parent mapping reveals epistatic architecture and elite haplotypes for multi-trait improvement in cotton.
  Cotton domestication has fixed favorable alleles, often masking cryptic loci and reinforcing genetic trade-offs, particularly between yield and fiber quality, thereby constraining simultaneous trait improvement.
  pubmed Han P, You C, Chen X, Wu Y 等 2026 Jul 15 置信度 0.82
• Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer.
  Progression from differentiated thyroid cancer to anaplastic thyroid cancer (ATC) involves profound epithelial plasticity and remodeling of the tumor microenvironment (TME), but how BRAF V600E and RAS driver mutations shape these processes remains unclear. Her…
  pubmed Joo EH, Song YS, Lee HS, Jung G 等 2026 Jul 16 置信度 0.82
• Exploration of viral diversity in Aedes mosquitoes employing different shotgun metagenomic data analysis pipelines.
  Metagenomics or metaviromics is emerging as a powerful technology for pathogen surveillance and pandemic preparedness. Mosquitoes are important vectors for transmission of many emerging viruses responsible for numerous outbreaks. Monitoring mosquitoes becomes …
  pubmed Gupta E, Sharma S, Tikar SN, Dash PK 2026 Jul 15 置信度 0.82
• Transcriptome analysis of follicular granulosa cells in young women with diminished ovarian reserve.
  Diminished ovarian reserve (DOR) is defined as the decline in both quantity and quality of oocytes in the ovarian cortex. In recent years, DOR has shown an increasing trend among young women. However, the specific etiology and detailed pathogenesis in this pop…
  pubmed Tian P, Lu Y, Zhang L, Chen H 等 2026 Jul 15 置信度 0.82
• Molecular epidemiological investigation of swine hepatitis e virus (sHEV) in Guangdong Province, China: prevalence, genotypic characteristics, and zoonotic risk.
  Hepatitis E virus (HEV) is a major zoonotic foodborne pathogen causing human acute hepatitis, with genotype 4 endemic in China and swine as its main reservoir. Guangdong has a large intensive swine industry, yet stratified molecular epidemiological data on swi…
  pubmed He Z, Liu D, Luo Q, Liu B 等 2026 Jul 15 置信度 0.82
• Network-based integration of metabolomics data from large-scale repositories.
  Public metabolomics data repositories such as MetaboLights and Metabolomics Workbench host rapidly growing volumes of raw data, processed results, and metadata. As data deposition becomes a prerequisite for funding and publication, there is an increasing need …
  pubmed Wieder C, Liedl ER, Payne T, Yurekten O 等 2026 Jul 15 置信度 0.82
• Role of chaihu yujin decoction in cholecystitis: a systematic investigation integrating multi-omics and experimental validation.
  To investigate the mechanism and effects of Chaihu Yujin Decoction (CYD) in the treatment of cholecystitis. This study employed an integrated network pharmacology and experimental approach to investigate CYD's mechanism against cholecystitis. Active compo…
  pubmed Xu F, Xu JH, Chen XM, Mao KL 等 2026 Jul 16 置信度 0.82
• Racial and Ethnic Disparities in Length of Stay for Pediatric Bacterial Tracheostomy-Associated Infections.
  Racial and ethnic disparities disproportionately impact children with medical complexity (CMC), including children with tracheostomies. Children hospitalized for bacterial tracheostomy-associated infections (bTRAINs) experience care variations that may exacerb…
  pubmed Rush M, Moffet I, Kono N, Hahn A 等 2026 Aug 1 置信度 0.82
• Genomic characterisation of ST11-KL19 carbapenem-resistant Klebsiella pneumoniae carrying dual carbapenemases and hypervirulence-associated markers.
  The global convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae poses a critical public health threat. While ST11-KL64 has historically dominated in China, the evolutionary dynamics driving the emergence of novel high-risk sublineage…
  pubmed Yan Z, Wu Y, Wang J, Dong H 等 2026 Jul 15 置信度 0.82
• Vibration-Controlled Transient Elastography-Based Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Saudi Arabia: A Prospective Cohort Study.
  Metabolic dysfunction-associated steatotic liver disease is the most common chronic liver disease worldwide. We aimed to estimate the prevalence, severity, and metabolic determinants of metabolic dysfunction-associated steatotic liver disease and liver fibrosi…
  pubmed Alqahtani SA, AlMuhaidib S, Sanai FM, Abaalkhail F 等 2026 Jul 15 置信度 0.82
• First nationwide full-genome characterisation of human-derived Andes virus in Chile: a retrospective genomic epidemiology study.
  Andes virus (ANDV) is the only hantavirus known to transmit between humans and causes hantavirus cardiopulmonary syndrome in Chile and Argentina. In Chile, ANDV genomic diversity remains incompletely characterised. This study aimed to characterise the genetic …
  pubmed Ramos H, Díaz-Gavidia C, Fuentes-Luppichini E, Díaz M 等 2026 Jul 15 置信度 0.82
• Assessment of differentially culturable tubercle bacteria assays for the detection of tuberculosis infection in asymptomatic household contacts and the implications for intra-household transmission: a longitudinal cohort study.
  Conventional culture methods for tuberculosis diagnosis miss differentially culturable tubercle bacteria (DCTB), which grow only in liquid assays supplemented with growth-enhancing factors. This limitation, combined with inadequate contact tracing and screenin…
  pubmed Sewcharran A, Gordhan BG, Tang L, Keenan S 等 2026 Jul 15 置信度 0.82