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WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
WDL Analysis Research Pipelines The WDL Analysis Research Pipelines (WARP) repository is a collection of cloud-optimized pipelines for processing biological data from the Broad Institute Data Sciences Platform and collaborators. WARP provides robust, standardi…
datacite
broadinstitute
2026
置信度 0.66
-
The operationalization of the One Health (OH) approach remains a major challenge due to persistent fragmentation across human, animal, and environmental data systems. This gap is exacerbated by climate change, which acts as a risk multiplier for pathogen trans…
pubmed
Sorrentino E, Mazzeo A, Mascolo C, Chiara MV 等
2026 Jun 29
置信度 0.82
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Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer type harboring TP53, TERT promoter and MAPK signaling alterations. Additionally, EZH2 overexpression leads to epigenetic silencing of tumor suppressor and cell differentiation genes. Here…
pubmed
Cristovão MM, de Mello DC, Kimura ET, Fuziwara CS
2026 Jul 18
置信度 0.82
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Natural killer cell large granular lymphocytic leukemia (NK-LGLL) is a rare and heterogenous lymphoproliferative disorder. This study retrospectively evaluated 35 consecutive Chinese patients (median age 58 years) to evaluate their unique clinical-biological p…
pubmed
Zhuang Z, Zhu H, Chen C, Di Y 等
2026 Jul 13
置信度 0.82
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Hexokinase 2 (Hxk2p) is a key enzyme in glucose metabolism but also acts as a central regulator linking glucose-dependent signaling with cellular physiology in Saccharomyces cerevisiae . Beyond its catalytic function in glycolysis, Hxk2p acts as a regulator of…
pubmed
Maslanka R, Folta J, Lubińska M, Słota Ł 等
2026 Jul 19
置信度 0.82
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Plant architecture and kernel-related traits are important determinants of yield potential and breeding value in peanut ( Arachis hypogaea L.). This study aimed to construct a high-density genetic linkage map, identify quantitative trait loci (QTL) associated …
pubmed
Xia Y, Zhang Z, Lin X, Wang C 等
2026 Jul 12
置信度 0.82
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Cancer is one of the leading causes of mortality and morbidity worldwide. Various studies have highlighted the involvement of microRNAs (miRNAs) in tumor initiation and progression. MiRNAs are endogenous, non-coding, single-stranded RNA molecules that interact…
pubmed
Sharma G, Lamichhane S, Chae SC
2026 Jul 5
置信度 0.82
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Background: PURA -related neurodevelopmental disorder ( PURA -NDD; OMIM #616158) is a rare autosomal dominant condition caused by pathogenic variants in the PURA gene encoding Purα, a multifunctional protein involved in DNA replication, transcriptional r…
pubmed
Madej-Pilarczyk A, Gawlik M, Chałupczyńska B, Błaszkiewicz J 等
2026 Jun 30
置信度 0.82
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Bovine-associated Klebsiella pneumoniae is an important bacterial species linking animal health, microbial ecology, and One Health-oriented antimicrobial resistance research. In this study, we performed a global genomic analysis of 1291 publicly available bovi…
pubmed
Tian M, Liang Y, Lu J, Shi W 等
2026 Jul 22
置信度 0.82
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Mitochondrial codon usage and selective pressures drive adaptive evolution and translation efficiency. This study provides insights into the evolutionary constraints shaping 13 core mitochondrial proteins in Corvides, based on 117 species, including 51 newly a…
pubmed
Xiao Y, Zhang M, Xi M, Han S 等
2026 Jul 19
置信度 0.82
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The size of the mitogenome varies greatly in angiosperms from different species, but the causes of expansion remain unclear. Species from the Zingiberaceae family often carry exceptionally large mitogenomes, where this phenomenon can be readily studied. C. kwa…
pubmed
Li Y, Qin Y, Shen J, Chen R 等
2026 Jul 9
置信度 0.82
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Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), members of the family Pneumoviridae, represent a foremost global cause of acute lower respiratory tract infection in infants, young children, the elderly, and immunocompromised individuals. De…
pubmed
Park YH, Kim R, Song KH, Jung HS
2026 Jul 13
置信度 0.82
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Metastatic disease remains the leading cause of cancer-related death, yet most precision oncology strategies still emphasize profiling primary tumors and tracking cell-free tumor DNA (ctDNA). Although ctDNA has transformed genomic profiling, molecular residual…
pubmed
Hashimoto T, Shibuki T, Fujisawa T, Boku S 等
2026 Sep
置信度 0.82
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Clinically relevant ALK alterations are identified across routine comprehensive genomic profiling (CGP), but their observed frequency may vary according to testing context. Because ALK-directed treatment is primarily linked to fusion/rearrangement events, we s…
pubmed
Kajiura S, Nakamura N, Hayashi R
2026 Jul 27
置信度 0.82
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Despite advances in tuberculosis treatment and prevention, tuberculosis remains a global health threat, responsible for an estimated 1.23 million deaths in 2024 [46], with continued concern over drug-resistant strains. In the Western Cape, South Africa, co-inf…
pubmed
Ambler JM, Potgieter MG, Klopper M, Grobbelaar M 等
2026 Jul 27
置信度 0.82
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Helicobacter (H.) pylori is characterized by a high degree of genomic diversity, with regional differences in virulence determinants. This study aims to explore genomic composition, phylogeography and accessory-gene relationships of Iraqi H. pylori isolates in…
pubmed
Ghareeb AM
2026 Nov
置信度 0.82
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Permafrost thawing due to global warming threatens to release long-preserved microbial communities, including potentially novel bacterial lineages. Despite the importance of West Siberian permafrost for climate models, genome-resolved studies of its microbial …
pubmed
Poshvina DV, Balkin AS, Vasilchenko AS
2026 Aug 4
置信度 0.82
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Molecular syndromic panels such as the BioFire FilmArray Gastrointestinal Panel (BF-GIP) have been widely adopted for gastrointestinal illness diagnosis due to their fast turnaround times and broad pathogen coverage. Recently, the BF-GIP demonstrated increased…
pubmed
Reed JC, Mauer C, Mack AR, Theriault EA 等
2026 Aug 12
置信度 0.82
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Patients with chronic kidney disease (CKD) are exposed to high levels of uremic toxins and have an increased risk of cardiovascular disease. Among these toxins, indolic compounds such as indoxyl sulfate (IS) are predictors of cardiovascular events and mortalit…
pubmed
Lefevre F, Chermiti R, Cebile J, McKay N 等
2026 Jul 10
置信度 0.82
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Dermatophytosis is a cutaneous mycosis caused by keratinolytic fungi, classified as dermatophytes, affecting 20-25% of the global population and representing a significant public health concern. The disease manifests as circular, erythematous, pruritic, and de…
pubmed
Silva LBBD, Oliveira LS, Furlan TBP, Almeida BCT 等
2026 Jul 9
置信度 0.82
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Antimicrobial resistance (AMR) is a global health crisis addressed through a One Health framework. However, recent European Union (EU) surveillance data reveals a marked divergence in progress between the human and animal sectors. This study analyzes the most …
pubmed
de Sousa T, Bugarim T, Igrejas G, Poeta P
2026 Jul 7
置信度 0.82
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Sickle cell disease (SCD) and thalassemia are genetic disorders that necessitate accurate diagnosis for effective management and improved patient outcomes. The advent of nanotechnology has paved the way for innovative, precise detection methods, offering enhan…
pubmed
Kaur M, Gautam JK, Sharma AR, Singh V 等
2026 Jul 8
置信度 0.82
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Environmental carcinogenesis is traditionally explained by the accumulation of genetic alterations induced by exogenous carcinogens. However, most exposed cells do not undergo malignant transformation because intrinsic tumor-suppressive mechanisms limit the ex…
pubmed
Blanco JR, Carnero A
2026 Jul 8
置信度 0.82
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Genomic testing is a key component of precision oncology; however, Black patients receive genomic testing at lower rates. The purpose of this qualitative study was to identify individual and health system drivers of genomic testing disparities at a National Ca…
pubmed
Thoumi A, Raveendran Y, Fish L, Gathings MJ 等
2026 Jul 10
置信度 0.82
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Antimicrobial resistance (AMR) is a growing problem, with annual deaths set to pass 10 million by 2050 if current trends continue. Sequencing untreated wastewater has been proposed as a strategy to understand population-level resistance, and water reclamation …
pubmed
Philo SE, Saldana MA, Golwala H, Zhou S 等
2026 Aug 19
置信度 0.82
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Among the estimated 234,580 patients diagnosed with lung or bronchus cancer in 2024, an estimated 66%, or 154,823 patients, were diagnosed with advanced or metastatic non-small cell lung cancer (mNSCLC). More than half of patients have a genomic variant that c…
pubmed
Migliaccio-Walle K, Spencer SJ, Veenstra DL, Dumanois RH 等
2026 Aug
置信度 0.82
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Bioinformatics approaches were employed to analyze 67 Legionella isolates collected from four districts of Beijing between 2023 and 2024, aiming to characterize the genomic features, virulence potential, and antimicrobial resistance mechanisms of Legionella, t…
pubmed
Gao B, Lin CY, Zhang DY, Zou L 等
2026 Jul 6
置信度 0.82
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Objective: To analyze the molecular typing, drug resistance, and virulence factors of Salmonella isolates collected in Liaocheng City, Shandong Province, from 2023 to 2024. Methods: A total of 43 Salmonella strains were subjected to serotyping, antimicrobial s…
pubmed
Cheng LH, Liang SN, Cui FY, Qian L 等
2026 Jul 6
置信度 0.82
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Methionine is an essential amino acid critical for T cell activation. While methionine restriction (MR) combined with immune checkpoint blockade has been shown to enhance T cell function, the impact of methionine on adoptive T cell therapies remains unknown. H…
pubmed
Zhao T, Carleton GA, Preshaw S, MacPherson S 等
2026 Jul 26
置信度 0.82
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We assessed how thermal tolerance strategies are associated with community diversity and phylogenetic context along a tropical elevational gradient, integrating community- and population-level perspectives by examining a widespread focal species together with …
pubmed
Chaves CJN, Tavares MM, Sabino GP, Bento JPSP 等
2026 Jul
置信度 0.82
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Atypical manifestations with a podal distribution have been occasionally reported in the USA, the UK and Israel in the early 2000s. The lesions were characterised by a tumor-like progression with a lack of remission over months and seemed to affect mostly olde…
pubmed
Segna A, Portobanco Villalobos ID, Ganter M, Ludlow M 等
2026 Jul 23
置信度 0.82
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Addiction "recovery" has served as a positive conceptual basis for major public health frameworks, communication strategies, and policies. With greater research interest and increasing explication of the recovery construct a multitude of measures have emerged,…
pubmed
Kelly JF, Zemore S, Vilsaint CL, Haegerich T 等
2026 Jul 17
置信度 0.82
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MicroRNAs play a pivotal role in driving colorectal cancer (CRC) progression through their influence on gene expression. In this study, we conducted a comprehensive analysis of gene expression profiles in CRC cell lines, focusing on the genes involved in the f…
pubmed
Oroujalian A, Keshani M, Panahi F, Esmaeili M 等
2026 Aug
置信度 0.82
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Outcomes in stage IV lung adenocarcinoma (LUAD) remain heterogeneous despite established genomic and immune biomarkers. We evaluated the prognostic and predictive value of soluble interleukin-2 receptor (sCD25), a marker of systemic inflammation and immune reg…
pubmed
Guo H, Liu L, Lindberg V, Xue Y 等
2026
置信度 0.82
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To identify preconception clinical and multi-omics factors associated with conception and early pregnancy loss in women with unexplained recurrent pregnancy loss (URPL).
pubmed
Song Z, Jiang Y, Zhu Z, Che Y 等
2026
置信度 0.82
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While the presence of metastases in neuroblastoma (NB) is a well-established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
pubmed
Morell-Daniel M, Pérez-Hoyos S, Soriano A, Coma A 等
2026 Sep
置信度 0.82
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Antibiotic resistance in Helicobacter pylori (H pylori) is influenced by multiple factors and shows significant geographical variation. Qinghai has a high incidence of gastric cancer and a high prevalence of H pylori infection, which may be exacerbated by fact…
pubmed
Wei S, Wang X, Xu L
2026 Jul 24
置信度 0.82
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Oral carcinoma in situ (OCIS) is a Stage 0 precancerous condition with a significant risk of developing into invasive oral squamous cell carcinoma. Despite this, the metabolic processes driving its onset and progression remain largely unknown. Lipid metabolism…
pubmed
Zhou H, Ma Z, Lei H, Zhou Y 等
2026 Jul 24
置信度 0.82
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Despite intensive vaccination efforts, Chicken Infectious Anemia Virus (CIAV) remains a formidable threat to the Egyptian poultry industry, primarily through the emergence of vaccine-escape variants. While most studies have focused on Northern Egypt, there is …
pubmed
Shosha EAE, Eldaghayes I, Zanaty AM, Gamaleldin MA 等
2026 Jul 24
置信度 0.82
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Passion fruit (Passiflora edulis) leaves displaying yellow spot symptoms were collected in La Réunion. Whilst viral indexing suggested single infections with potyviruses, high-throughput sequencing revealed both single and mixed infections involving cowpe…
pubmed
Lett JM, Hoareau M, Parvedy E, Clain C 等
2026 Jul 25
置信度 0.82
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Influenza viruses have high mutation rates and cause serious health problems worldwide. In our population, no study has examined mutations and their variation relative to the wild-type and vaccine strains.
pubmed
Owaid FM, Fadhil HY
2026 Nov
置信度 0.82
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Adeno-associated virus (AAV) vector-mediated gene transfer is an emerging treatment strategy for severe cardiac disorders with genetic etiology. We refined the AAV toolkit to achieve efficient and selective expression of the therapeutic transgene in mouse hear…
pubmed
Galkin II, Skopenkova VV, Shubina MY, Polikarpova AV 等
2026 Jul 17
置信度 0.82
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Background/Objectives: Parental environmental factors can shape developmental outcomes through epigenetic mechanisms that regulate gene expression. While maternal dietary effects on offspring epigenetics have been well characterized, the impact of paternal die…
pubmed
Graybeal JT, Kizilaslan Z, Kizilaslan M, Taylor T 等
2026 Jul 6
置信度 0.82
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Mycobacterium abscessus complex (MABC), comprising Mycobacterium abscessus subsp. abscessus (MABa), Mycobacterium abscessus subsp. bolletii (MABb), and Mycobacterium abscessus subsp. massiliense (MABm), is an emerging group of non-tuberculous mycobacteria with…
pubmed
Oudhaya K, Kalaiarasan E, Alex A, Hyma KPV 等
2026 Jul 13
置信度 0.82
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Surgical site infection (SSI) is a major complication after ileal pouch-anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte-to-C-reactive protein ratio (LCR), a composite marker of systemic infl…
pubmed
Koike Y, Higashi K, Sato Y, Nagano Y 等
2026 May 25
置信度 0.82
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Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a major healthcare-associated pathogen with high multidrug resistance and mortality. Regional clonal spread of high-risk lineages carrying carbapenemase genes poses significant challenges for infection cont…
pubmed
Shou X, Li X, Yang H, Zhang X
2026
置信度 0.82
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Inherited ocular disorders are a leading cause of early-onset visual impairment, particularly in populations with high consanguinity such as Iran, where a substantial proportion of affected individuals remain without a molecular diagnosis after conventional ev…
pubmed
Asadi A, Sadat Shandiz SA, Ebrahimi A, Hosseini ZS 等
2026 Sep
置信度 0.82
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pubmed
Greenbaum D
2026
置信度 0.82
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Genetic testing is increasingly used in clinical practice. This places new demands on non-genetic physicians (NGPs) to select appropriate tests, interpret complex results, and counsel patients about implications. In highly consanguineous countries such as Saud…
pubmed
Zakariyah AF, Edrees A, Almutadares M, Khan MA 等
2026 Jul 24
置信度 0.82
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Intrinsically disordered regions (IDRs) are widely recognized as facilitators of chromatin regulation. However, their potential role as regulatory restraints remains poorly understood. Here we reveal that the C-terminal IDR of mammalian ALKBH5 anchors its main…
pubmed
Jiang L, Zhao L, Wei J, Jiang B 等
2026 Aug
置信度 0.82
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Cancer arises from genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states. To chart cancer-intrinsic regulatory programs, we build a pan-cancer single-cell atlas of 60 cancer cell lines spanning 16 tiss…
pubmed
Xu Z, Ugurbil A, Kwan J, Schaefer C 等
2026 Jul 23
置信度 0.82
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Serous effusion smears categorized as suspicious for malignancy (SFM) pose significant diagnostic challenges. This study aimed to evaluate the diagnostic utility of argyrophilic nucleolar organizer region (AgNOR) quantification across International System for …
pubmed
Salih MM, Alotaibi SA, Yousif AAM, Elmissbah TE 等
2026 May
置信度 0.82
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Antimicrobial resistance (AMR) in Helicobacter pylori is increasingly compromising eradication therapies worldwide. Despite growing concern, comprehensive global genomic analyses integrating resistance determinants, geographic distribution, and evolutionary pa…
pubmed
Alhusseini LB, Laftah AR, Jaafar FN, Kouhsari E 等
2026 Jul 23
置信度 0.82
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Molecular Tumor Boards (MTBs) are widely implemented in precision oncology, yet no health system has established a mandatory outcome accountability framework. This article uses Italy's nationally mandated MTB programme, established by Ministerial Decree in 202…
pubmed
Iannopollo M, Berti G
2026 Sep
置信度 0.82
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Carbapenem resistance in Acinetobacter baumannii is usually mediated by acquired carbapenemases. Here we investigated an alternative mechanism involving variants of the intrinsic Acinetobacter-derived cephalosporinase (ADC).
pubmed
Gaillot S, Oueslati S, Kiener S, Bour M 等
2026 Jul 23
置信度 0.82
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Gene therapies that selectively eliminate tumor cells within a heterogenous population remain an elusive goal in oncology, largely due to the difficulty to achieve cancer specificity by strict definition. Here, we engineer a therapeutic gene circuit capable of…
pubmed
Liu Q, Xiong Q, Xie G, Chen Q 等
2026 Aug 18
置信度 0.82
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Despite a significant decline in the incidence of neonatal sepsis, the clinical imperative to avoid missing life-threatening infection continues to drive widespread antibiotic overprescription. Antimicrobial stewardship is universally recognized and explicitly…
pubmed
Duret A, Davies F, Fitzgerald F, Gilchrist M 等
2026 Aug
置信度 0.82
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Emerging evidence highlights the critical role of amino acid metabolism in the pathogenesis and severity of COVID-19. This review included studies encompassing patients with varying degrees of disease severity, from mild to critical cases.
pubmed
Soltani S, Choobineh H, Nabatchian F, Kord M 等
2026 Dec
置信度 0.82
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Escherichia coli is predominantly an intestinal commensal; however, avian pathogenic E. coli (APEC) causes colibacillosis in poultry. The APEC pathotype lacks a clear genetic definition, further complicated by its opportunistic nature. To compare the genomic c…
pubmed
Davam H, Jansson DS, Nord E, Halvarsson P 等
2026 Jul
置信度 0.82
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Stroke is a major complication of atrial fibrillation (AF), and risk prediction using the congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex category score (CHA₂DS₂-VASc) remains limited by residual heterogen…
pubmed
Huang S, Feng X, Wu H, Liang R 等
2026 Jul 23
置信度 0.82
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Colonization with difficult-to-treat-resistant Gram-negative bacteria (DTR-GNB) increases the risk of subsequent infections with limited treatment options. This study aimed to assess the burden of DTR-GNB colonization in ICU patients, explore its association w…
pubmed
Mamun GMS, Rahaman MS, Khan S, Islam MA 等
2026 Jul 23
置信度 0.82
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Clostridioides difficile ( C. difficile ) is the primary pathogen responsible for nosocomial infectious diarrhea and pseudomembranous colitis. In China, metronidazole and vancomycin are the preferred treatments for C. difficile infection (CDI). This study aime…
pubmed
Lao J, Zhang L, Huang X, Du G 等
2026 Jul 23
置信度 0.82
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Microsatellite instability (MSI) is one of the four molecular classes of endometrial carcinomas (EC) identified by The Cancer Genome Atlas (TCGA), which is associated with an intermediate prognosis. The identification of mismatch deficient (MMRd) tumors has be…
pubmed
Amin DI, Yaseen HA
2026 Jul 23
置信度 0.82
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Human adenovirus type C (HAdV-C) causes upper respiratory infections in children and may lead to severe pneumonia. During the implementation and subsequent relaxation of non-pharmaceutical interventions, HAdV-C emerged as a transiently dominant circulating str…
pubmed
Wu C, Mai C, Zhao Z, Zhang S 等
2026
置信度 0.82
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Computational modelling is a widely used approach for understanding complex biological systems, enabling researchers to formalise mechanisms, analyse dynamic behaviours, and generate predictive insights across multiple biological scales. The BioModels Model of…
pubmed
Malik Sheriff RS, Asari H, Geris L, Hermjakob H 等
2026
置信度 0.82
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Lower respiratory tract infections (LRTIs) progress swiftly and require timely, accurate pathogen detection to enhance patient outcomes. This study aims to utilize the targeted metagenomic next-generation sequencing (tNGS) technology as a novel approach to inv…
pubmed
Ni Y, Wu W, Liu J, Feng C 等
2026
置信度 0.82
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Chlamydia psittaci is an important zoonotic pathogen mainly transmitted to humans through exposure to infected birds or contaminated bird excreta, and infection may range from mild respiratory illness to severe systemic disease.
pubmed
Cui W, Wu S, Chen Q, Lei X 等
2026
置信度 0.82
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Spectrin Repeat-Containing Nuclear Envelope Protein 1 (SYNE1) is important gene for maintaining neuronal structure and function, particularly in the cerebellum, the brain region responsible for coordinating movement. The genetic mutation in SYNE1 gene, which e…
pubmed
Haque A, Alam MZ, Bibi F, Muthaffar OY 等
2026 Jul
置信度 0.82
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Accurate single-molecule optical genome mapping remains challenging due to the limited information content of barcode-only or profile-only strategies. Here, we present Dual Optical Mapping (DOM), which integrates sequence-specific barcode markers with AT frequ…
pubmed
Bae J, Kim Y, Choe J, Hong J 等
2026 Aug
置信度 0.82
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In recent years, many high-quality reference genome sequences for arthropod species have been generated. Although most genome papers describe their protocols and metrics, no consensus exists on the data that should be included in genome reports. Here, we revie…
pubmed
Tvedte ES, Bucher G, Luecke DM, Molik DC 等
2026 Jul 23
置信度 0.82
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Childhood T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with poor prognosis. Differently from B-cell precursor ALL, T-ALL lacks effective risk stratification strategies. A recent study has integrated whole genome and wh…
pubmed
Stoiber L, Antić Ž, Rebellato S, Fazio G 等
2026 Jul 22
置信度 0.82
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Adeno-associated virus (AAV)-based gene therapy has demonstrated transformative potential in treating hereditary hearing loss (HHL). Investigating factors that influence AAV transduction in target and non-target organs is critical for improving therapeutic pre…
pubmed
Han S, Zhou Y, Tang H, Hu SW 等
2026 Jul 22
置信度 0.82
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The nuclear genome is spatially organized into a three-dimensional architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina at the radial periphery and nuclear speckles within the nucleoplasm 1…
pubmed
Ahanger SH, Semenza ER, Zhang C, Gil E 等
2026 Jul 22
置信度 0.82
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Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease and can trigger life-threatening neurological complications, yet the sequence-level physicochemical correlates of CNS involvement across globally circulating lineages remain incompletely defined. He…
pubmed
Wang X, Li F
2026 Sep
置信度 0.82
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Oropouche virus (OROV) is an emerging virus that causes a wide spectrum of febrile illnesses in humans. In this study, we examined two of the most commonly used primer sets for the clinical diagnosis of OROV to identify potential reduction in diagnostic sensit…
pubmed
Avendano A, Mavian C, Balzano-Nogueira L, Ait Said M 等
2026 Nov
置信度 0.82
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The field of machine learning in antimicrobial resistance (AMR) research has experienced rapid growth, fueled by advancements in high-throughput genome sequencing and the growing capacity of computational resources. However, the complexity and lack of standard…
pubmed
Yurtseven A, Joeres R, Kalinina OV
2026 Aug 3
置信度 0.82
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Capsular polysaccharide (CPS) is essential for Streptococcus pneumoniae virulence. Yet, the mechanism linking CPS to peptidoglycan (PG) remains unclear. Here, we identified a strong negative genetic interaction between the genes encoding the putative capsule l…
pubmed
Zik JJ, Fu Z, Price MN, Li Y 等
2026 Aug 12
置信度 0.82
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Missing values (MVs) remain a significant barrier to reliable proteomics analysis, particularly in single-cell proteomics, where small amounts of starting material and limits in detection drive missing-not-at-random (MNAR) sparsity. Existing imputation methods…
pubmed
Shi Y, Davis S, Charles PD, Taylor S 等
2026 Aug 7
置信度 0.82
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The emergence and dissemination of mcr-1 has raised global public health concerns, and poultry is a major reservoir. However, systematic investigations of mcr-1 -positive Escherichia coli in Jiangxi Province, an important poultry production base in southern Ch…
pubmed
Liu WQ, Tan J, Huang JN, Ji HY 等
2026
置信度 0.82
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A roving field survey (2022-2024) across Tamil Nadu revealed begomoviral incidence ranging from 13 to 100%, influenced by cultivar, growth stage, virus species, and geography. Typical symptoms included mosaic, mottling, stunting, leaf malformation, curling, ve…
pubmed
Sivagnanapazham K, Karthikeyan G, Boopathi N, Pradeep RKM 等
2026 Aug
置信度 0.82
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Large-scale interrogation of genome structure is crucial for understanding how genomic organization influences cellular function, yet existing methods are limited by the low density of achievable modifications or the toxicity of methods. Here we address this g…
pubmed
Riedmayr LM, Koeppel J, Church GM, Parts L 等
2026 Jul 21
置信度 0.82
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Senescence, the endpoint of normal cells' replicative lifespan, is accompanied by a complex sequence of molecular events. One such event is the dramatic reorganization of CTCF into senescence-induced clusters (SICCs). However, the molecular determinants, genom…
pubmed
Palikyras S, Varamogiani-Mamatsi V, Zhu Y, Mizi A 等
2026 Aug
置信度 0.82
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The terrestrial subsurface hosts one of Earth's largest biomes, with groundwater systems representing major habitats for microbial life. In these environments, microbes persist under energy scarcity caused by the absence of photosynthesis, physical isolation a…
pubmed
Küsel K, Dopson M
2026 Aug
置信度 0.82
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Uropathogenic Escherichia coli (UPEC) strains are the primary cause of urinary tract infections and pose a serious clinical problem due to their remarkable genetic variability, diverse virulence traits, and rapidly increasing antibiotic resistance. In this stu…
pubmed
Wesołowski W, Czerwonka G, Zegadło K, Jagieła E 等
2026 Jul 21
置信度 0.82
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Severe early-onset-chronic obstructive pulmonary disease (SEO-COPD) represents the most severe form of COPD that manifests at an earlier age than common COPD. We hypothesise that this is driven by a partially different disease pathogenesis and investigated whe…
pubmed
Bekker NJ, Van Nijnatten JL, Horvatovich PL, Wolters JC 等
2026 Jul 21
置信度 0.82
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The KIR3DL3*04802 full-length sequence by PacBio in Han individual differs from KIR3DL3*04801 by nine nucleotides.
pubmed
Zhen J, Zhang Q
2026 Jul
置信度 0.82
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The phase III JBCRG-M06/EMERALD study was the first to show noninferior progression-free survival (PFS) of eribulin to taxane, combined with dual human epidermal growth factor receptor 2 (HER2) blockade (trastuzumab plus pertuzumab), as a first-line treatment …
pubmed
Saji S, Yamashita T, Tsurutani J, Sagara Y 等
2026 Aug
置信度 0.82
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The unfolded protein response (UPR) helps reinstate cellular proteostasis upon an accumulation of misfolded proteins in the endoplasmic reticulum (ER), in part through ER-associated degradation (ERAD). Ube2j2 is an ER-localized E2 ubiquitin-conjugating enzyme …
pubmed
Dahlberg CL, Zinkgraf M, Laugesen SH, Søltoft CL 等
2026 Jul 21
置信度 0.82
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Chemotherapy-induced nausea and vomiting (CINV) significantly impact quality of life of patients with cancer. Although antiemetic guidelines exist for low-emetic chemotherapy (LEC), recommendations vary across international guidelines and direct evidence compa…
pubmed
Aoyama T, Iihara H, Abe M, Wada M 等
2026 Sep
置信度 0.82
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Ovarian cancer (OC) is one of the most lethal gynecological malignancies, with incidence and mortality rates increasing markedly among women aged 65 years and older. Aging-associated biological alterations, including genomic instability, telomere attrition, ox…
pubmed
Paul BM, Kannan G, Karuppasamy A, Thangaraj P
2026 Aug
置信度 0.82
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The aim of this study was to perform molecular characterization of the carbapenem-resistant Enterobacter cloacae complex (ECC) isolates from colonized patients in a hospital using whole-genome sequencing (WGS) technology. As part of routine surveillance for mu…
pubmed
Ríos E, Rodríguez-Avial I, López R, Martínez M 等
2026 Jul 21
置信度 0.82
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Streptococcus agalactiae is a significant opportunistic pathogen causing severe infections, including urinary tract infections and pyelonephritis in diabetic individuals. To explore the molecular mechanisms behind this susceptibility, we used a streptozotocin-…
pubmed
Pena JMS, de Oliveira LL, Souza YP, Barnabé CF 等
2026 Aug 3
置信度 0.82
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Influenza A(H1N1)pdm09 continues to evolve through antigenic drift, posing challenges to vaccine effectiveness. The present study investigated the evolutionary dynamics, glycosylation patterns, and immunological features of the hemagglutinin (HA) gene of Influ…
pubmed
Sarmah N, Siddique AI, Dutta M, Gogoi S 等
2026 Jul
置信度 0.82