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Population divergence is promoted by divergent selection and inhibited by gene flow, but the mechanisms of and relationship between these two processes remain poorly understood. Developing a well-informed hypothesis of the selective pressures underlying diverg…
pubmed
Amoroso J, Farleigh K, Crispo E, Blair C
2026 Aug 28
置信度 0.82
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Resectable non‑small cell lung cancer (NSCLC) is managed largely according to anatomical stage, pathological risk and actionable driver alterations, yet these factors do not fully explain postoperative recurrence. Genomic instability may contribute to r…
pubmed
Wang L, Feng Y, Liu Q
2026 Oct
置信度 0.82
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A multi-layered genetic structure shaped by multiple demographic events across different time periods has been well documented in some species. However, evaluating this pattern remains challenging in many wide-ranging wildlife because genome-wide datasets with…
pubmed
Endo Y, Osada N, Mano T, Abramov AV 等
2026 Aug 28
置信度 0.82
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BMI is widely used to define obesity and may not capture heterogeneity in body fat distribution. Genetic studies of obesity have largely focused on BMI but not visceral fat and fat-free mass, which is particularly limited in East Asian populations. This study …
pubmed
Lu HM, Chang SJ, Luo KH, Chuang YS 等
2026 Aug 28
置信度 0.82
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Dams can landlock populations of amphidromous fishes that formerly migrated between rivers and seas. However, the genetic consequences of these life-cycle changes remain unclear. Rhinogobius is a speciose genus of freshwater gobies widely distributed in Asia, …
pubmed
Chan JCF, Low BW, Lau A, Rheindt FE 等
2026 Sep
置信度 0.82
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The STING1-IRF1 axis plays a crucial role in sensing innate immunity within the tumor microenvironment. However, the genomic landscape of this axis and its clinical implications in breast cancer still require a deeper understanding, more comprehensive explanat…
pubmed
Alhamadani I, Alzeyadi M
2026 Aug 1
置信度 0.82
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Cholangiocarcinoma (CCA) is a highly malignant cancer that develops in the bile ducts. Its incidence is particularly high in East Asian populations, but the underlying genetic factors remain unclear. To investigate potential risk factors for CCA, we conducted …
pubmed
Elgeshy K, Nagaoka K, Yamazaki H, Honda M 等
2026 Aug 1
置信度 0.82
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The objective of this study is to investigate germline CNVs in the BRCA1 and BRCA2 genes.
pubmed
Sukpan P, Khongcharoen N, Samphao S
2026 Aug 1
置信度 0.82
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Avocado mesocarp is a unique non-seed tissue capable of accumulating high levels of oil, yet the metabolic regulation underlying this process during fruit development remains poorly understood. We investigated how central carbon metabolism is coordinated with …
pubmed
Olmedo P, Ponce E, Hernández I, Carrasco-Pancorbo A 等
2026 Aug 28
置信度 0.82
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The efficacy and safety of the M72/AS01E tuberculosis (TB) candidate vaccine were evaluated in the phase 2b randomized, placebo-controlled trial NCT01755598. In the trial, participants with Mycobacterium tuberculosis sensitization by a positive interferon-gamm…
pubmed
Wattiau P, Omar SV, Joseph L, Demoitié MA 等
2026 Aug 28
置信度 0.82
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Non-communicable disorders (NCDs) in women of reproductive age (WRA) shape maternal and intergenerational outcomes, yet their area-level socio-environmental drivers remain unclear. We examined correlations between socio-environmental factors and NCDs in WRA.
pubmed
Mulyadi CH, Hui L, Jiang H, de Leon M 等
2026 Oct
置信度 0.82
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Plant breeding has progressed from phenotype-based selection to increasingly precise genetic and agronomic interventions. Advances in molecular breeding, genome engineering, and crop management have improved productivity, but have also promoted the widespread …
pubmed
Joshi S, Mao Y, Gross-Hardt R
2026 Aug 28
置信度 0.82
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Mixed-type outcome data occur when the outcome variable's distribution is a mixture of both continuous and discrete ordinal variables. Such mixed-type outcomes are common in biomedical, psychological, and the health sciences, particularly for variables having …
pubmed
Sun S, Mas VR, Archer KJ
2026 Sep
置信度 0.82
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This study investigated the clonal dissemination and molecular basis of linezolid-, tigecycline- and vancomycin-resistant E. faecium (LTVRE) isolates in a surgical intensive care unit (SICU) of a Chinese hospital.
pubmed
Zeng K, Shen W, Cai J
2026 Aug 4
置信度 0.82
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Genome-wide association studies (GWAS) have shown that pleiotropy, whereby a single genetic variant or gene influences multiple traits, is common in complex human diseases. Detecting cross-phenotype associations from GWAS summary statistics remains challenging…
pubmed
Feng CY, Sugier PE, Zou N, Liquet B
2026 Sep
置信度 0.82
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Lung cancer is characterised by high mortality and encompasses various subtypes with markedly different treatment outcomes. While individual subtypes have been studied, comprehensive genome-wide and fine-scale DNA methylation analyses across subtypes remain un…
pubmed
Dong Z, Luo Y, Hu T, Cheng Y 等
2026 Sep
置信度 0.82
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Companion animals are increasingly recognised within One Health antimicrobial-resistance (AMR) surveillance, yet the global genomic structure of dog- and cat-associated Klebsiella pneumoniae remains poorly defined. We assembled a global dataset of 712 domestic…
pubmed
Fordham SME, Sheridan E, Drobniewski F
2026
置信度 0.82
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This article evaluates and summarizes key therapeutic advances and supportive care considerations for metastatic gastrointestinal stromal tumors (GISTs).
pubmed
Chung C, Albayeh A
2026 Aug 28
置信度 0.82
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The cuticle is an ancient innovation that enabled plants to colonize land by providing a protective yet selectively permeable barrier. Although its composition is well characterized, the developmental and environmental regulation of cuticle permeability remain…
pubmed
Kim K, Kang J, Jeon WT, Lee JM 等
2026 Aug 28
置信度 0.82
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Recent advances in sequencing technology have made the sequencing of non-model organisms significantly more streamlined and feasible. Using these technologies, we begin to address the lack of data on non-model organisms, by sequencing the genome of one such sp…
pubmed
Grebler E, Liesenfelt T, Masonick PK, Mongue AJ
2026 Aug 28
置信度 0.82
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Flowering plants respond to multiple environmental and endogenous cues to determine the timing of their transition from the vegetative to floral state. Most of our knowledge of the gene regulatory network (GRN) controlling the floral transition has been derive…
pubmed
Sidhu GS, Burrows S, Woolfenden H, Wells R 等
2026 Aug 28
置信度 0.82
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To explore the clinical presentation and molecular etiology for a patient with Fahr disease due to a variant of JAM2 gene.
pubmed
Ma Q, Shao W, Wang Y, Hu Z 等
2026 Sep 10
置信度 0.82
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To analyze a novel exonic variant of the SALL1 gene and its impact on the binding site of SALL protein.
pubmed
Chi Y, Sun F, Zhang Z, Wang Y 等
2026 Sep 10
置信度 0.82
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To explore the genetic characteristics of a complex balanced translocation involving four non-homologous chromosomes in a Chinese pedigree using optical genomic mapping (OGM).
pubmed
Huang Y, Chen Y, Lin S, Zhang Z 等
2026 Sep 10
置信度 0.82
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To explore the correlation between clinical manifestations and variants of fibrillin-1 (FBN1) gene in eight patients with Marfan syndrome (MFS).
pubmed
Wu R, Sun L, Liu B, Fu X 等
2026 Sep 10
置信度 0.82
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To explore the clinical features and genetic etiology of a child with Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS).
pubmed
Zhao Y, Li N, Han Y, Li N 等
2026 Aug 10
置信度 0.82
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Herpesviruses are a widespread and diverse family of large double-stranded DNA viruses. Narrow host ranges maintained over long evolutionary times have fostered intimate host adaptations. However, such close virus-host associations inevitably invite conflict. …
pubmed
Höfler T, Abdulrahman DA, Reich J, Kossak L 等
2026
置信度 0.82
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High-throughput sequencing generates vast amounts of FASTQ data, posing significant storage and transmission challenges. We propose FastqCA, a reference-free, cellular automaton-based compressor designed to exploit two-dimensional spatial redundancy across rea…
pubmed
Long S, Wei Q, Zou Y, Zhou Y 等
2026
置信度 0.82
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Coronavirus (CoV) spillover from wildlife to humans is increasing and has caused major global epidemics, facilitated by human-induced habitat alteration that promotes zoonotic emergence. This highlights the need for sustained surveillance and a better understa…
pubmed
Jiménez-Rico MA, Vigueras-Galván AL, Tolsá-García MJ, Martínez-Duque P 等
2026
置信度 0.82
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Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and is an independent risk factor for kidney and systemic degenerative diseases. On 16 May 2025, the Aging Biomarker Con…
pubmed
Aging Biomarker Consortium, Zhang X, Chen A, Lv L 等
2026 Aug
置信度 0.82
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With the first regulatory approval in 2023 of a CRISPR-based therapy for sickle cell disease followed by the recent demonstration of an accelerated, personalized CRISPR treatment for congenital severe carbamoyl-phosphate synthetase 1 deficiency, CRISPR-Cas9 ge…
pubmed
Şahin C, Formica TM, Silva A, Della Pelle G 等
2026 Sep 8
置信度 0.82
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The purpose of this study was to investigate genetic risk factors associated with ischemic heart disease (IHD) in Russian adults, to develop prognostic PRS models for IHD risk stratification, and to gain a better understanding of molecular mechanisms underlyin…
pubmed
Daniel V, Romanova N, Mamchur A, Nartova A 等
2026
置信度 0.82
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Cystic fibrosis (CF) is a devastating genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. As morbidity and mortality from CF results from a lack of mucus clearance that leads to chronic bacterial infect…
pubmed
Sinha V, Ayoub PG, Juett CJ, Lathrop LE 等
2026 Sep 8
置信度 0.82
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Antibiotic resistance is a growing global threat, and the chicken gut microbiome is a significant reservoir of antibiotic resistance genes (ARGs). To investigate the presence of ARGs in free-range chickens, which are in closer contact with humans and live in c…
pubmed
Qi D, Liu J, Bai X, Chen B 等
2026 Sep
置信度 0.82
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The Earth Hologenome Initiative (EHI) is generating standardized datasets that jointly capture host genomic and microbial metagenomic-namely hologenomic-information across wild vertebrates. These resources include thousands of shotgun hologenomic datasets and …
pubmed
Alberdi A, Martin-Bideguren G, Lauritsen J, Gaun N 等
2026
置信度 0.82
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Cryptochromes and photolyase-related (CRY/PHR) proteins are flavoproteins involved in blue-light signaling and/or the light-dependent repair of UV-induced DNA damage across all domains of life. Although well-studied in many eukaryotes, their evolution and func…
pubmed
Virágh M, Szafián DA, Csernetics Á, Liu XB 等
2026 Sep 18
置信度 0.82
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Viet Nam has one of the world's most diverse hepatitis C virus (HCV) epidemics, dominated by genotype 6. Understanding pre-treatment resistance-associated substitutions (RASs) particularly in under-studied genotype 6 is important for informing resistance surve…
pubmed
Le Ngoc C, Chai H, Airey G, Das T 等
2026 Aug
置信度 0.82
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The genus Acanthaspis (Hemiptera: Reduviidae) comprises predatory insects of ecological importance, yet mitochondrial genomic resources for this group remain limited. Here, we present the complete mitochondrial genome of Acanthaspis geniculata (Hsiao, 1976). T…
pubmed
Liu W, Chen J, Lin J, Wang P 等
2026
置信度 0.82
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5-Hydroxytryptophan (5-HTP) is a functional precursor of serotonin; however, achieving sustained 5-HTP production in vivo by engineered microbes remains challenging. To address this, we developed a genome-integrated engineered probiotic system enabling gut-loc…
pubmed
Wu J, Yang Y, Li T, Zhang B 等
2027 Apr
置信度 0.82
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The immune system protects against pathogens, responds to abiotic stress, maintains homeostasis, and supports tissue repair. Recent work identified four transcriptional dimensions of immune variation-immune resistance, inflammation, metabolism, and tissue repa…
pubmed
Brandes-Leibovitz R, Yankovitz G, Bacharach E, Netea MG 等
2026 Sep 18
置信度 0.82
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Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is a clinically aggressive disease state with limited treatment options. While individual biomarkers, imaging modalities, and genomic drivers have each been studied in isolation, the dynamic relat…
pubmed
Tan G, Zhang Y, Mao Z, Zhang C 等
2026
置信度 0.82
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NF2-related schwannomatosis ( NF2 -SWN) is an inherited autosomal dominant disorder resulting from loss-of-function mutations in the NF2 gene, for which no effective treatment is currently available. Furthermore, truncating variants in NF2 are associated with …
pubmed
Casals-Sendra G, Jarne-Sanz I, Catasús N, Boluda-Luis I 等
2026 Sep 8
置信度 0.82
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The Charolais sheep is a world-renowned breed of meat sheep, known for its large frame, heavy muscling, and rapid growth. A novel breed, the Chao Mu meat sheep, has been developed by utilizing the Charolais sheep as the paternal line. This advancement has sign…
pubmed
Ge J, Qi Z, Xin J, Shi Y 等
2026
置信度 0.82
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To test the feasibility of a self-directed, in-home, contactless salivary dim light melatonin onset (DLMO) assessment protocol to remotely measure endogenous circadian phase in participants with circadian rhythm disorders and healthy controls.
pubmed
Bormes G, Love JJ, Burns AC, Akeju O 等
2026
置信度 0.82
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early characterization of outbreak cases supports rapid decisions. We conducted real-time analysis during the initial outbreak phase in mid-March 2025 of Sierra Leone's first 44 laboratory-confirmed Mpox cases (10 th January to 5 th March 2025) to generate epi…
pubmed
Ikoona EN, Gebru GN, Faye M, Magoba B 等
2026
置信度 0.82
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Coronary abnormalities are late complications of arterial switch operation for transposition of the great arteries (ASO-TGA) and may remain silent for decades. We evaluated the feasibility and diagnostic performance of stress CT myocardial perfusion imaging (C…
pubmed
Gkizas C, Longere B, Domanski O, Rodriguez-Musso A 等
2026 Aug
置信度 0.82
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Carbon catabolite repression (CCR) is a widespread regulatory strategy across diverse microorganisms that prioritises the utilisation of preferred carbon sources. In industrial bioprocesses, however, CCR-mediated substrate hierarchy can delay the utilisation o…
pubmed
Lu M, Ding H, Zhang H, Xu J 等
2027 Apr
置信度 0.82
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DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives…
pubmed
Sabuakham S, Kitdumrongthum S, Nasoontorn S, Monmai C 等
2026 Aug 25
置信度 0.82
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The global burden of kidney stones is increasing, while di(2-ethylhexyl) phthalate (DEHP), a widespread plasticizer and endocrine-disrupting pollutant, has been implicated as a potential environmental risk factor. This study investigated the mechanisms by whic…
pubmed
Wang Y, Pu J, Xun Y, Yu X
2026
置信度 0.82
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Primula octopoda W.B.Ju & Q.Huang, a new species of Primula (Primulaceae) in sect. Aleuritia , is herein described and illustrated from Batang County, Sichuan Province, southwestern China. Morphologically, P. octopoda is most similar to P. stenocalyx , but…
pubmed
Huang Q, Wang X, Huang WJ, Yang JY 等
2026 Sep
置信度 0.82
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Canonical HIV-1 entry into target cells depends on binding to CD4 as a primary receptor. Because of this, use of the CD4 receptor as a viral trap (a decoy receptor used to prevent infection of target cells) is a promising strategy for the treatment of HIV-1. O…
pubmed
Luna SE, Feist WN, Ben-Efraim K, Pendergast A 等
2026 Sep 10
置信度 0.82
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Recovery of adeno-associated virus (AAV) vectors from culture supernatants has attracted increasing interest as a strategy to simplify downstream processing and improve product purity. However, several AAV serotypes can be re-internalized by producer cells, ra…
pubmed
Sakamoto K, Yoshida K, Tsunekawa Y, Guzman Mendoza NA 等
2026 Sep 10
置信度 0.82
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Theileria , an obligate intracellular parasitic protozoan transmitted primarily by ixodid ticks, poses a significant threat to animal health and livestock productivity. This study conducted a comprehensive investigation into the prevalence and genetic diversit…
pubmed
Cui J, Wang F, Rao H, Dang B 等
2026 Aug
置信度 0.82
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CYP2J2 catalyzes the conversion of arachidonic acid into epoxyeicosatrienoic acids (EET), which have gained significant attention due to their oncogenic properties. Differential overexpression of CYP2J2 in tumors results in increased EET production. The role o…
pubmed
Manhas D, Jamwal A, Kaur G, Akhter MQ 等
2026 Aug 25
置信度 0.82
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Okra, an economically important vegetable in tropical and subtropical regions, faces severe yield constraints due to sap-sucking pests, particularly jassids ( Amrasca spp.). These insects cause hopper burn, leaf curling, and chlorosis, leading to estimated yie…
pubmed
Vihou F, Yarou BB, Lin YP, Wu X 等
2026
置信度 0.82
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Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolate…
pubmed
Wu L, Liu Y, Huang R, Zhao Y 等
2026 Aug 27
置信度 0.82
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Prime editing has rapidly emerged as a versatile and precise genome engineering technology capable of introducing targeted substitutions, insertions, and deletions without requiring double-strand breaks or donor DNA templates. Since its initial development, su…
pubmed
Muhammad W, Cao X, Umar A, Nauman K 等
2026 Sep
置信度 0.82
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Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interacti…
pubmed
Siam NH, Mithila UH, Tisha SA, Saha H 等
2026 Sep
置信度 0.82
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Leigh Syndrome Spectrum (LSS) is the most common pediatric mitochondrial disease syndromic presentation. However, its natural history has not been well-characterized, particularly across diverse populations.
pubmed
MacMullen LE, Stanley KD, Christodoulou J, Cohen BH 等
2026 Jan-Dec
置信度 0.82
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Microbial halogenated natural products (hNPs) hold ecological, agricultural, and biomedical relevance. The hNP-producing potential of an organism can be assessed by the precise prediction of halogenating enzymes, yet detailed annotations of halogenases are oft…
pubmed
Szenei J, Burke A, Liong A, Korenskaia A 等
2026 Aug 25
置信度 0.82
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This data article describes the complete chloroplast genome sequence data of Camellia handelii Sealy, a fragrant-flowered species of Camellia sect. Theopsis . Fresh young leaves were collected from a cultivated individual in Changsha, China. Genomic DNA was ex…
pubmed
Xiao Z, Yan J
2026 Aug
置信度 0.82
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Pediococcus pentosaceus is a Gram-positive lactic acid bacterium known for food fermentation, probiotic properties, and bacteriocin production. This study reports draft contig-level whole genome sequence data of four P. pentosaceus strains (MBBL_PB1 - MBBL_PB4…
pubmed
Homa F, Arafat KY, Khan S, Hemal MAK 等
2026 Aug
置信度 0.82
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Tuberculosis (TB) caused by Mycobacterium tuberculosis complex (MTC) is a growing public health concern for elephants and humans in Nepal. We tested 99 captive Asian elephants ( Elephas maximus ) in Chitwan valley for MTC antibodies and interviewed 223 mahouts…
pubmed
Rajbhandari RM, Queirós J, Lyashchenko KP, Napit R 等
2026 Dec
置信度 0.82
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Antibiotic resistance is a growing challenge in the treatment of bacterial infections, prompting interest in alternative therapies. Understanding how bacterial populations evolve under different selective pressures is important for predicting resistance pathwa…
pubmed
McGee LW, Radtke NK, Taylor GS, Graves JL Jr 等
2026 Sep
置信度 0.82
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Carbapenems are among the last-line antibiotics for treating severe Gram-negative infections. Comamonas spp. are increasingly recognized for their clinical pathogenicity; however, carbapenem-resistant isolates have rarely been documented.
pubmed
Wang Y, Zeng M, Gu Y
2026
置信度 0.82
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Chimeric antigen receptor T-cell therapy has changed the treatment landscape of relapsed or refractory hematological malignancies, but primary non-response and post-infusion relapse remain frequent clinical problems. In aggressive B-cell lymphomas, acute leuke…
pubmed
Cai S, Tan Y, Yang Q, Huang J
2026
置信度 0.82
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Pseudomonas aeruginosa is a significant opportunistic pathogen, particularly prevalent in intensive care units (ICUs). Through a comprehensive genomic and phenotypic analysis of 518 ICU and healthy isolates collected over a 13-year period (2010-2022), we found…
pubmed
Huang J, Chen K, Xie M, Shen W 等
2026 Aug 27
置信度 0.82
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Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics-gene expression, metabolic flux, and signal transduction-within predictive e…
pubmed
Zhang LA, Dong X, Liu K, Gonzalez N 等
2026 Aug
置信度 0.82
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Although cells within an organism share nearly identical genomes, their transcriptional programs differ markedly due to reversible chemical modifications known as epigenetic marks. These marks, including DNA methylation and histone modifications, regulate gene…
pubmed
Faiq A, Haider S, Mussolino C
2026 Sep 10
置信度 0.82
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The rapid expansion of multi-omics data has created an increasing demand for accessible and reproducible platforms for integrative analysis. Here, we present Wekemo Bioincloud 2026, a comprehensive upgrade of the original platform, providing 41 standardized wo…
pubmed
Gao Y, Zhang G, Wang C, Xu H 等
2026 Aug
置信度 0.82
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Genome-resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low- and high- methane-emitting dairy cows despite limited taxonomic differences. Differential methylatio…
pubmed
Zhang X, Xu G, Zhao L, Tao Y 等
2026 Aug
置信度 0.82
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Ovalbumin (OVA) is an important egg white protein that is widely used in food applications owing to its functional properties. Although precision fermentation offers a sustainable alternative for OVA production, limited extracellular secretion remains a signif…
pubmed
Lee W, Yun DI, Kim SK
2026 Aug
置信度 0.82
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Platinum-based chemotherapy cures most patients with advanced testicular germ cell tumours (TGCTs), yet a subset develops resistance or relapse. The molecular basis of platinum sensitivity and resistance remains unclear, particularly in archival formalin-fixed…
pubmed
Hitchen N, Bedard PL, Winegarden N, Sweet J 等
2026
置信度 0.82
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Taraxacum mongolicum Hand.-Mazz. is rich in dietary fiber and has been reported to exhibit hypoglycemic activity. This study investigated the effects of lactic acid bacteria (LAB)-fermented dandelion Jiangshui (JS) on glucose metabolism and pancreatic and rena…
pubmed
Meng XG, Lu JN, Yao H, Jin QK 等
2026
置信度 0.82
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Salvia miltiorrhiza is a widely used Asian medicinal plant valued for its bioactive compounds and therapeutic benefits. However, it is often adulterated with the closely related species S. yunnanensis , complicating identification by conventional PCR and HPLC …
pubmed
Hu YK, Phong NV, Lee HJ, Cha MR 等
2026 Aug
置信度 0.82
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Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality, and effective prognostic stratification remains urgently needed. Ribonucleotide reductase (RR), consisting mainly of RRM1 and RRM2, plays a critical role in nucleotide metabolism and …
pubmed
Zheng K, Jiang H, Wen Y, Xiang J 等
2026
置信度 0.82
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Urticaceae is an ecologically diverse family, yet comparative studies on plastome structure and codon usage remain limited. To investigate the structural evolution and codon usage patterns in Urticaceae, we sequenced the complete chloroplast genome of Urtica c…
pubmed
Gao F, Fan W, Wang Z, Smagghe G 等
2026
置信度 0.82
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Broussonetia papyrifera (paper mulberry) is an economically important species in East Asia used for fiber production, traditional medicine, and ecological restoration. During a field survey, virus-like symptoms, including chlorotic mottling and mosaic were obs…
pubmed
Belete MT, Lee SJ, Lim S
2026 Jun
置信度 0.82
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Artificial intelligence (AI) is reshaping molecular precision medicine through biomarker discovery, genomic variant interpretation, molecular imaging, multi-omics analysis, and patient-specific therapeutic support. In Saudi Arabia, genomic medicine and digital…
pubmed
El-Nakib I, Soliman K
2026
置信度 0.82
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As key components of the diurnal oscillation pathway, FKF1 family genes are well known to promote flowering under inductive photoperiods in model plants, yet their biological function in potato flowering and tuberization under specific photoperiodic conditions…
pubmed
Zhai Z, Liu Y, Li H, Sun W 等
2026 Sep
置信度 0.82
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We present two near-complete triticale genome assemblies and perform pan-centromere analyses across >200 haplotypes from parental species, synthetic allopolyploids, cultivars, and 337 resequenced accessions, revealing a shared chromatin framework underlying…
pubmed
Liu Y, He W, Wang C, Yi C 等
2026 Aug
置信度 0.82
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Lichens represent complex symbiotic systems consisting of a fungal partner and photosynthetic microorganisms, and they could also harbor diverse associated microbiota including viruses. Despite increasing interest in mycoviruses from filamentous fungi, viruses…
pubmed
Edis G, Sahin E, Keskin E, Akata I
2026 Jun
置信度 0.82
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Tuberculous meningitis (TBM) is a severe central nervous system infection in which dysregulated host inflammation contributes to neurological injury. The cellular organization of the cerebrospinal fluid (CSF) immune microenvironment in TBM, particularly in com…
pubmed
Hu H, Hou L, Wang Y, Yu Z 等
2026
置信度 0.82
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Paris polyphylla is an endangered medicinal herb valued for its steroidal saponins, yet the phenotypic stability, genetic diversity, and quality differentiation of cultivated populations remain insufficiently understood.
pubmed
Jiang J, Qin Y, Yu Z, Chen J 等
2026
置信度 0.82
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Arboviruses are important causes of human disease, and several species also infect wild animals that may serve as amplifying hosts. Among these, yellow fever virus ( Orthoflavivirus flavi ) is a major cause of morbidity and mortality in neotropical primates. I…
pubmed
Dos Santos DO, de Campos BH, Vieira AD, Ribeiro LN 等
2026
置信度 0.82
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Plant regeneration is widely exploited in genetic transformation, genome editing, tissue culture, cuttage, and grafting, which are crucial means to improve crop productivity and resilience. However, plant regeneration is heavily restricted by their low regener…
pubmed
Song Y, Zhang L, Hu Z, Tvorogova VE 等
2026 Sep
置信度 0.82
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Autoinflammatory diseases (AIDs) are a heterogeneous group of innate immune-driven disorders whose prevalence is rising globally, yet the lack of disease-specific biomarkers continues to hamper accurate disease activity assessment, phenotype stratification, an…
pubmed
Yang Q, Zhang Y, Li X, Sun S 等
2026
置信度 0.82
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Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen resistant to several widely used antibiotics. Although MRSA has historically been associated with hospital- and community-associated infections, livestock-associated MRSA (LA-MRSA) has …
pubmed
Bogaerts B, Kowalewicz C, De Keersmaecker SCJ, Roosens NHC 等
2026
置信度 0.82
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Wei and colleagues reported a pH-responsive, charge-switchable polyzwitterionic polymer carrier that achieves non-invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenviron…
pubmed
Chen J, Liu Y, Xia B, Essola JM 等
2026 Aug 26
置信度 0.82
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Juvenile polyposis syndrome (JPS) is a rare autosomal-dominant disorder characterized by numerous juvenile hamartomatous polyps in the gastrointestinal tract (GIT), increasing cancer risk. Pathogenic and likely pathogenic (P/LP) variants in the SMAD4 or BMPR1A…
pubmed
Suárez JJ, Benavides J, Rubio-Vargas AC, Lott PC 等
2026
置信度 0.82
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CD3γ deficiency is an ultrarare autosomal recessive inborn error of immunity characterized by immune dysregulation and variable immunodeficiency. To date, only 16 predominantly pediatric cases have been reported. Here, we describe two additional adult pa…
pubmed
Obeng R, Elsayed A, Takyi A, von Hardenberg S 等
2026
置信度 0.82
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Individuals with attention-deficit/hyperactivity disorder (ADHD) show an elevated incidence of non-small cell lung cancer (NSCLC), usually attributed to smoking. Innate immune activation and chronic inflammation are implicated in both, yet whether shared germl…
pubmed
Yu T, Wang P, Zheng Z, Zhao K 等
2026
置信度 0.82
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Bacillus species are ubiquitous in nature, and they display diverse traits of biotechnological importance, including the production of various enzymes and secondary metabolites. In this study, we profiled the genomes of vineyard-derived Bacillus strains shown …
pubmed
Kayode AJ, Wanjofu EI, Setati ME
2026
置信度 0.82
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Constitutional chromosomal abnormalities detected during bone marrow (BM) chromosome analysis may be misclassified as acquired abnormalities. Although incidental findings identified through somatic tissue testing are increasingly recognized, data on incidental…
pubmed
Kim J, Seo EJ
2026 Aug 28
置信度 0.82
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Locomotor capacity is a major determinant of fitness and is strongly modulated by exercise-induced physiological plasticity. In vertebrates, sustained submaximal exercise typically promotes a shift toward an aerobic muscle phenotype, characterized by enhanced …
pubmed
Mantulak RK, Gill SK, Rossi GS, Little AG
2026 Aug 28
置信度 0.82
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Insomnia is closely linked to herpes zoster (HZ) and postherpetic neuralgia (PHN); nonetheless, the causal relationship has not been sufficiently clarified. This research employs the Mendelian randomization (MR) method to investigate the causal relationship be…
pubmed
Yang X, Li X, Lin J, Chen Y 等
2026
置信度 0.82
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The gut microbiota plays an important role in childhood growth and metabolic regulation and may interact with the growth hormone (GH)-insulin-like growth factor-1 axis. However, the gut microbiota characteristics in children with GH deficiency (GHD) are poorly…
pubmed
Choi SY, Kong SG, Yeon GM, Hong YR 等
2026 Aug 19
置信度 0.82
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Cerebral small vessel disease (CSVD) describes a range of neurological diseases affecting the small arteries, veins, and capillaries which supply the white matter and deep grey matter structures of the brain. They are the most common form of cerebrovascular di…
pubmed
Guyler SK, Maksemous N, Lea RA, Smith RA 等
2026 Aug 27
置信度 0.82
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There is a wide spectrum of tumour and tumour-like lesions in soft tissue and bone. Fine needle aspiration cytology (FNAC) is a cheap and accessible method that can provide a rapid diagnosis in most instances. We have evaluated the usefulness of FNAC for bone …
pubmed
Husu A, Wessman S, Wallander K, de Flon FH
2026 Aug 27
置信度 0.82
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pubmed
Zubairi R
2026 Sep
置信度 0.82