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BACKGROUND Acute myocardial infarction (AMI) reflects inherited susceptibility and inflammatory remodeling, but the cellular contexts linking genetic risk to disease remain unclear. MATERIAL AND METHODS We integrated a meta-transcriptome-wide association study…
pubmed
Ruan R, Xu X, Liu Q, Xiang F 等
2026 Aug 28
置信度 0.82
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Heart and kidney diseases frequently coexist, but the genetic basis of this relationship remains unclear. We analyzed genetic data from large-scale studies to investigate how kidney function (estimated glomerular filtration rate, eGFR) and six common cardiovas…
pubmed
Li W, Chen Y, Xiong W, Yuan S
2026 Dec
置信度 0.82
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African swine fever virus genotype II was detected in wild boar in Spain in 2025 after >30 years of absence. Whole-genome sequencing and molecular follow-up of 8 representative cases identified a stable 9.8-kb deletion affecting the multigene family in the …
pubmed
Gallardo C, Marcet-Houben M, Agüero M, Nieto R 等
2026 Sep
置信度 0.82
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Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin-maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246). The S…
pubmed
Peduto C, Huber C, Paya C, Audo I 等
2026 Aug 27
置信度 0.82
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Multiple sex chromosome systems provide exceptional models for investigating the genomic mechanisms underlying sex chromosome evolution. In Neotropical primates, owl monkeys (Aotus) are notable for their extensive karyotypic diversity and recurrent emergence o…
pubmed
Toma GA, de Oliveira EHC, Maurício KD, Carneiro LA 等
2026 Aug 27
置信度 0.82
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Polygenic risk scores (PRS) are increasingly being incorporated into clinical care, yet optimal strategies for communicating PRS results to patients and clinicians remain undefined. Effective report design is critical to ensure comprehension and appropriate us…
pubmed
Griffin JN, Danowski ME, Gerety HL, Lafferty K 等
2026 Jul 30
置信度 0.82
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Litopenaeus vannamei is an economically important species in global aquaculture. Enhancing its environmental resistance through selective breeding is important for improving the efficiency of intensive farming. Genomic selection (GS) can speed up genetic impro…
pubmed
Fu S, Zhang Y, Wu G, Guo C 等
2026 Aug 27
置信度 0.82
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Soil salinization severely restricts the growth, yield, and industrial development of apricot (Prunus armeniaca L.). WRKY transcription factors play crucial roles in plant responses to abiotic stresses. However, the genome-wide characteristics of the WRKY fami…
pubmed
Li Y, Han X, Gao H, Yang J 等
2026 Jul 27
置信度 0.82
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pubmed
Kammerer S
2026 Sep
置信度 0.82
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We analyzed whole-genome sequencing data for 1,046 human clinical and 1,332 nonclinical Listeria monocytogenes isolates collected across New York, USA, during 2000-2021. Several hypervirulent clonal complexes (CCs) were significantly associated with clinical i…
pubmed
Samut H, Mendez-Vallellanes DV, Hoyt H, Wirth SE 等
2026 Sep
置信度 0.82
-
pubmed
2026 Aug 27
置信度 0.82
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pubmed
Su M, Zhao W, Jiang H, Zhao Y 等
2026 Aug 27
置信度 0.82
-
Previously derived polygenic risk scores (PRSs) for Alzheimer's disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ance…
pubmed
Kurniansyah N, Tasaki S, Rehman H, Zhu C 等
2026 Aug 27
置信度 0.82
-
Face2Gene is a clinical tool that leverages facial features to aid genetic diagnosis. The DeepGestalt application suggests potential diagnoses based on facial similarity, while the D-Score evaluates likelihood of an individual having dysmorphic features sugges…
pubmed
Bruwer Z, Mc Donald H, Zieff MR, Eastman E 等
2026 Aug 27
置信度 0.82
-
Although copy number variants (CNVs) represent well-established genetic contributors to schizophrenia (SCZ), their role in bipolar disorder (BD), especially within non-European ancestries, has been inadequately explored. We evaluated the genome-wide load of ra…
pubmed
Wu Y, Li X, Sun Y, Zhang C 等
2026 Aug 27
置信度 0.82
-
Aeromonas spp. are critical aquatic pathogens affecting global aquaculture and human health, yet their taxonomy is frequently confounded by persistent horizontal gene transfer and high recombination rates. While whole-genome sequencing offers definitive resolu…
pubmed
Abdella B, Shokrak NM, Mohamed RA, El-Helow ER
2026 Aug 27
置信度 0.82
-
Microtubules are well-researched components of the cytoskeleton, yet we lack a holistic understanding that bridges molecular and cellular details with the broader functions of the microtubule cytoskeleton in development, ageing and disease. For example, how mi…
pubmed
Janke C, Akhmanova A, Bartolini F, Bodakuntla S 等
2026 Aug 27
置信度 0.82
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Aposematism and crypsis are contrasting antipredator strategies widespread across animal taxa, yet their genetic basis remains poorly understood in amphibians. Aposematic species advertise toxicity through conspicuous coloration, whereas cryptic species rely o…
pubmed
Cajigas Gandia A, Pröhl H, Metzger J, Rodríguez A
2026 Aug 25
置信度 0.82
-
Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 d…
pubmed
Ioannidou C, Manzanares-Sierra I, Jimenez-Blasco D, García-Rodriguez D 等
2026 Aug 27
置信度 0.82
-
Variants of flowering time genes identified from selective sweep selection of cotton breeding lines. Day-neutrality is essential for modern upland cotton (Gossypium hirsutum L.) cultivation at temperate latitudes, yet the molecular basis of the transition from…
pubmed
Pinnika G, Wubben MJ, McCarty JC, Fang DD 等
2026 Aug 27
置信度 0.82
-
Synthetic messenger RNA (mRNA) is emerging as next generation vaccine platform. As natural 5'UTRs of particular genes do not work for other than its own mRNA, it is essential to identify an ideal 5'UTR supporting higher translation efficiency for different ant…
pubmed
Sajjanar B, Gopinath S, Nadarajan P, Marreddy VK 等
2026 Aug 27
置信度 0.82
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Aging is accompanied by widespread DNA methylation changes, yet their full genomic scope and parent-of-origin dynamics remain poorly understood. Here, we apply nanopore long-read sequencing to 7,284 whole blood samples enabling methylation measurements of 17,9…
pubmed
Sigurpalsdottir B, Holley G, Sverrisson SÞ, Magnusdottir DN 等
2026 Jul 29
置信度 0.82
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Beyond serving as cohesive barriers, epithelia clear apoptotic cells to regulate development, homeostasis and inflammation. How epithelial cells remodel their shape during phagocytosis while preserving tissue integrity, and the role of adhesion receptors in th…
pubmed
Häkkinen HM, Batet M, Bianchi LF, Jiménez-Delgado S 等
2026 Aug 27
置信度 0.82
-
Combinatorial group testing can reduce experimental costs and turnaround time by strategically pooling samples to minimize the number of measurements needed for a given experiment. Despite broad potential utility, it remains underutilized due to its intrinsic …
pubmed
Talamanca L, Trouillon J
2026 Aug 25
置信度 0.82
-
Dopamine plays a critical role in animal physiology and interactions with gut microbes. In plants, dopamine is known to function in plant defense and abiotic stress tolerance; however, its role in mediating plant-microbiome interactions remains unexplored. In …
pubmed
Ding Y, Vogel HK, Zhai Y, Carlson HK 等
2026 Jul 29
置信度 0.82
-
Pseudomonas aeruginosa is a ubiquitous, Gram-negative bacterium that forms biofilms and is responsible for antibiotic-resistant hospital-acquired infections in humans. The P. aeruginosa BqsRS two-component system regulates biofilm formation and dispersal by se…
pubmed
Paredes A, Hull M, Singh H, Greene D 等
2026 Jul 29
置信度 0.82
-
Alternative splicing is a fundamental mechanism underlying protein diversity. The microtubule-associated protein tau (MAPT) undergoes age-associated alternative splicing of exon 10 to generate 3 R and 4 R isoforms, and disruption of the 4 …
pubmed
Li X, Syed I, Adhikari R, Jiang J 等
2026 Jul 29
置信度 0.82
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Characterizing the variation in clonal trajectory of age-related mosaic chromosomal alterations (mCAs) in circulating leukocytes can identify etiologic factors influencing clonal expansion and hematologic malignancy risk. Here we scan whole blood-derived DNA o…
pubmed
Kelly RL, Brown DW, Zhou W, Hubbard AK 等
2026 Jul 29
置信度 0.82
-
Ribozyme-based approaches have been extensively employed for in vitro circular RNA (circRNA) synthesis. However, several critical challenges are impeding the progress in this field, including the relatively low ribozyme utilization efficiency, limited syntheti…
pubmed
Wang L, Zhai Q, Dong C, Zhang W 等
2026 Jul 28
置信度 0.82
-
Tumor cell heterogeneity and interactions with the immune microenvironment play a key role in the progression and therapeutic efficacy of natural killer/T-cell lymphoma (NKTCL). We perform single-cell RNA sequencing analysis of 63 samples, integrating spatial …
pubmed
Cao Y, Cai J, Dai D, Wang J 等
2026 Jul 29
置信度 0.82
-
Protein function annotation is crucial for understanding biological processes and mechanisms. Traditionally, annotations rely on sequence homology, providing valuable insights but often leaving gaps even in well-characterised organisms. With AlphaFold enabling…
pubmed
Del Missier G, Shabestary K, Ledesma-Amaro R
2026 Jul 28
置信度 0.82
-
Parkinson's disease (PD) is defined pathologically by loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). Yet synaptic dysfunction emerges much earlier, making it essential to define the mechanisms that drive early nigrostriatal der…
pubmed
Chen C, He Q, Tombesi G, Napier E 等
2026 Jul 28
置信度 0.82
-
Accurate segregation of mitotic chromosomes requires pre-anaphase alignment driven by microtubule-based motor proteins. Tubulin detyrosination is essential to guide CENP-E-driven chromosome congression in mitosis. However, the mechanisms of action and physioch…
pubmed
Yang T, Hu W, Xu P, Li H 等
2026 Jul 30
置信度 0.82
-
Synthetic biology demands plasmid with tunable copy numbers. While dynamic plasmid copy number (PCN) regulation has been engineered in prokaryotes, a parallel capability remains unavailable in eukaryotic systems. Here, we develop a programmable PCN platform fo…
pubmed
Li A, Zhao Q, Yang Z, Cheng J 等
2026 Jul 28
置信度 0.82
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Efficient co-utilization of hexose and pentose sugars from lignocellulose is essential for microbial bioconversion, yet engineered catabolic pathways can be unstable or suboptimal in complex resource environments. Here, we use a Pseudomonas putida strain engin…
pubmed
Woo S, Lim HG, Norton-Baker B, Lind TM 等
2026 Jul 29
置信度 0.82
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Upon T cell receptor (TCR) engagement, phosphorylation of the LAT adapter protein enables binding of the enzyme PLC-γ1 to a Gads/SLP-76 dimer, forming a tetrameric structure. The interaction between SLP-76 and PLC-γ1 is weak within this heterotetra…
pubmed
Yamane H, Wada J, Stassenko EN, Convertino ND 等
2026 Jul 29
置信度 0.82
-
Mechanical loading is crucial for maintaining bone mass, and understanding how bone remodels in response to mechanical loading is essential for treating musculoskeletal disorders. Recently, sensory nerves inside bone were identified as mechanical regulators of…
pubmed
Tsujino S, Ochi H, Okada R, Kamimura D 等
2026 Aug 28
置信度 0.82
-
Coxiella burnetii is an environmentally stable intracellular bacterium responsible for severe global outbreaks of the zoonotic disease, Q fever. Q fever is transmitted by the inhalation of aerosols contaminated with the birth products and excretions of infecte…
pubmed
Choi Y, Kim D, Choi YJ, Choi SW 等
2026 Aug 28
置信度 0.82
-
Anal high-grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab-based screening and highlight t…
pubmed
Rozemeijer K, Claesen J, Dias Gonçalves Lima F, Hesselink AT 等
2026 Aug 27
置信度 0.82
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Homologous recombination repairs DNA double-strand breaks by copying genetic information from an intact DNA template, but how the homologous sequence is located within the vast 3D genome remains unclear. In this forum, we discuss how cohesin, a key chromatin o…
pubmed
Bagelova Polakova S, Cipak L, Gregan J
2026 Aug 27
置信度 0.82
-
PARP inhibitors are life-prolonging therapies for men with homologous recombination repair (HRR) deficient mCRPC. Estimates of PARPi benefit in diverse patient populations are limited. Here we describe patterns of PARPi use and outcomes in mCRPC in the nationw…
pubmed
Bitting RL, Tseng CL, Giagtzis A, Wyatt AW 等
2026 Aug 5
置信度 0.82
-
pubmed
Phillips C, Brown B, Machin N, Bibby DF 等
2026 Aug 27
置信度 0.82
-
A novel HLA-B allele was identified in a Brazilian volunteer bone marrow donor.
pubmed
de Medeiros MGB, Massi FP, de Souza Terron M, Visentainer JEL 等
2026 Sep
置信度 0.82
-
This is a ClinGen Criteria Specification approved by the ClinGen Clinical Domain Working Group Oversight Committee and the ClinGen Variant Curation Expert Panel Review Committee. Usage subject to the Clinical Genome Resource's Terms of Use (https://clinicalgen…
datacite
Severe Combined Immunodeficiency Disease Variant Curation Expert Panel
2025
置信度 0.66
humanbiologygenomicsvariantvariant classification
-
This is a ClinGen Criteria Specification approved by the ClinGen Clinical Domain Working Group Oversight Committee and the ClinGen Variant Curation Expert Panel Review Committee. Usage subject to the Clinical Genome Resource's Terms of Use (https://clinicalgen…
datacite
Severe Combined Immunodeficiency Disease Variant Curation Expert Panel
2026
置信度 0.66
humanbiologygenomicsvariantvariant classification
-
Repository maintenance release. Figures 5 and 6 finalised for publication (legend text, kbp units, panel font sizing). Genome inputs for the dN/dS robustness subsample resolve via DATA_ROOT (portable defaults). The UPSCb-common submodule is referenced over HTT…
datacite
Street, Nathaniel
2026
置信度 0.66
-
Repository maintenance release. Figures 5 and 6 finalised for publication (legend text, kbp units, panel font sizing). Genome inputs for the dN/dS robustness subsample resolve via DATA_ROOT (portable defaults). The UPSCb-common submodule is referenced over HTT…
datacite
Street, Nathaniel
2026
置信度 0.66
-
Cancer comprises a heterogeneous group of multifactorial diseases that emerge through the accumulation and selection of cellular alterations within an organism simultaneously influenced by genetic, environmental, metabolic, immune, endocrine, and behavioral fa…
datacite
Vicent Navarro Maronda
2026
置信度 0.66
Immunology and Infectious DiseaseNeoplasmsPhysiologyDiseasesMedicine and Health Sciences
-
kmer2stats is a bioinformatics tool that processes k-mer count tables and computes statistical summaries such as diversity metrics and frequency-based statistics.
datacite
Faack, Santino
2026
置信度 0.66
k-merbioinformaticsgenomicssequence analysis
-
Sparse departures from independence in two-way tables: a heteroscedasticity profile and detection boundary, an adaptive higher-criticism gate, and an assumption-lean exact anchor William J. Dwyer, MD, MPH, FAAP — Department of Mathematics and Statistics, Unive…
datacite
Dwyer, William J.
2026
置信度 0.66
contingency tablesparse detectionhigher criticismdetection boundaryheteroscedastic Gaussian sequence
-
Sparse departures from independence in two-way tables: a heteroscedasticity profile and detection boundary, an adaptive higher-criticism gate, and an assumption-lean exact anchor William J. Dwyer, MD, MPH, FAAP — Department of Mathematics and Statistics, Unive…
datacite
Dwyer, William J.
2026
置信度 0.66
contingency tablesparse detectionhigher criticismdetection boundaryheteroscedastic Gaussian sequence
-
This is a ClinGen Criteria Specification approved by the ClinGen Clinical Domain Working Group Oversight Committee and the ClinGen Variant Curation Expert Panel Review Committee. Usage subject to the Clinical Genome Resource's Terms of Use (https://clinicalgen…
datacite
Rett and Angelman-like Disorders Variant Curation Expert Panel
2025
置信度 0.66
humanbiologygenomicsvariantvariant classification
-
This archive provides reproducible analysis code, manuscript-facing derived tables, statistical documentation, and integrity checks for a public-data computational multiomics study of a placental vitamin-D-associated regulatory signature. The workflow includes…
datacite
Jing, Wen, Jia, Lu
2026
置信度 0.66
- placenta - vitamin D - single-cell multiomics - chromatin accessibility - villous cytotrophoblast - fetal brain - xQTL - candidate prioritization - developmental genomics - autism spectrum disorder
-
This archive provides reproducible analysis code, manuscript-facing derived tables, statistical documentation, and integrity checks for a public-data computational multiomics study of a placental vitamin-D-associated regulatory signature. The workflow includes…
datacite
Jing, Wen, Jia, Lu
2026
置信度 0.66
- placenta - vitamin D - single-cell multiomics - chromatin accessibility - villous cytotrophoblast - fetal brain - xQTL - candidate prioritization - developmental genomics - autism spectrum disorder
-
Gene finding as process of identification of genomic DNA regions encoding proteins , is one of the important scientific research programs and has vast application in structural genomics ,functional genomics ,metabolomics, transcriptomics, proteomics, genome st…
datacite
Ghorbani, Mahin, Karimi, Hamed
2015
置信度 0.66
Gene findingGene predictionbioinformatics toolsgenome studyInsilco approaches.
-
Gene finding as process of identification of genomic DNA regions encoding proteins , is one of the important scientific research programs and has vast application in structural genomics ,functional genomics ,metabolomics, transcriptomics, proteomics, genome st…
datacite
Ghorbani, Mahin, Karimi, Hamed
2015
置信度 0.66
Gene findingGene predictionbioinformatics toolsgenome studyInsilco approaches.
-
ViruFunc Atlas v1.0 is a leakage-aware benchmark and reusable evaluation resource for viral protein function annotation. The release provides frozen manifests for 713,487 viral proteins, 19,149 genomes, 1,283 viral families, and 17 primary function labels. It …
datacite
Wang, Kuanghao
2026
置信度 0.66
viral protein function annotationviral genomicsbenchmarkleakage-aware evaluationgenome context
-
ViruFunc Atlas v1.0 is a leakage-aware benchmark and reusable evaluation resource for viral protein function annotation. The release provides frozen manifests for 713,487 viral proteins, 19,149 genomes, 1,283 viral families, and 17 primary function labels. It …
datacite
Wang, Kuanghao
2026
置信度 0.66
viral protein function annotationviral genomicsbenchmarkleakage-aware evaluationgenome context
-
ViruFunc Atlas v1.0 is a leakage-aware benchmark and reusable evaluation resource for viral protein function annotation. The release provides frozen manifests for 713,487 viral proteins, 19,149 genomes, 1,283 viral families, and 17 primary function labels. It …
datacite
Wang, Kuanghao
2026
置信度 0.66
viral protein function annotationviral genomicsbenchmarkleakage-aware evaluationgenome context
-
ViruFunc Atlas v1.0 is a leakage-aware benchmark and reusable evaluation resource for viral protein function annotation. The release provides frozen manifests for 713,487 viral proteins, 19,149 genomes, 1,283 viral families, and 17 primary function labels. It …
datacite
Wang, Kuanghao
2026
置信度 0.66
viral protein function annotationviral genomicsbenchmarkleakage-aware evaluationgenome context
-
Abdominal aortic aneurysm (AAA) is a complex, life-threatening disease marked by an enlargement of the abdominal aorta. Traditional diagnosis relies on measuring abdominal aortic diameter (AAD) from imaging data collected during clinical evaluation, but this s…
datacite
Hussain Kousar, Muhammad Umer
2026
置信度 0.66
bioinformaticsGenetic Loci/geneticsGenomicsImaging GenomicsTranscriptomics
-
Abdominal aortic aneurysm (AAA) is a complex, life-threatening disease marked by an enlargement of the abdominal aorta. Traditional diagnosis relies on measuring abdominal aortic diameter (AAD) from imaging data collected during clinical evaluation, but this s…
datacite
Hussain Kousar, Muhammad Umer
2026
置信度 0.66
bioinformaticsGenetic Loci/geneticsGenomicsImaging GenomicsTranscriptomics
-
Sialidases are glycohydrolytic enzymes that remove sialic acid residues from gangliosides, sialoglycoproteins and oligosaccharides. The most recently identified member of the human sialidase family is Neu4 and is found in two forms, NEU4 long (Neu4L) and NEU4 …
datacite
F. Cirillo
2010
置信度 0.66
-
This issue is part of the International Virtual University of Regenerative Health (IVURH) Newsletter Foundational Series, issued on 2009-02-08. It develops the proposed academic architecture of a College of Regenerative Health Sciences within IVURH, organizing…
datacite
Yusuf, MD, M A
2009
置信度 0.66
MedicineRegenerative Medicine
-
This issue is part of the International Virtual University of Regenerative Health (IVURH) Newsletter Foundational Series, issued on 2009-02-08. It develops the proposed academic architecture of a College of Regenerative Health Sciences within IVURH, organizing…
datacite
Yusuf, MD, M A
2009
置信度 0.66
MedicineRegenerative Medicine
-
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