-
Background: Hematopoietic stem/progenitor cell (HSPC) transplantation outcomes depend critically on the dose of functional stem cells delivered to patients, yet current ex vivo cell therapy manufacturing processes lack reliable methods to quantify therapeutic …
pubmed
Xavier-Ferrucio J, Ung M, Norman F, Li BE 等
2026 Jun 5
置信度 0.82
-
Cell and gene therapy products face unique regulatory challenges due to their biological complexity and the stringent expectations for manufacturing control, analytical testing, and clinical assessment. As the pipeline grows, understanding the drivers of FDA n…
pubmed
Babcock E, Riggins C
2026 Jun 6
置信度 0.82
-
Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence linking resistance determinants …
pubmed
Sato T, Yamamoto S, Toyting-Hiraishi J, Tohyama M 等
2026 Aug 5
置信度 0.82
-
Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the human leukocyte antigen (HLA) region have long been recognised as key determinants of graft survival, increasing…
pubmed
Kammer M, Heinzel A, Shoebridge S, Reindl-Schwaighofer R 等
2026 Aug 5
置信度 0.82
-
Obtaining tissue from advanced non-small cell lung cancer(NSCLC) patients is difficult, yet mutation testing is crucial for targeted therapy. This study evaluates the clinical utility of serous cavity effusion (SCE) supernatant for multi-gene mutation testing,…
pubmed
Dong L, Cao Y, Liu Y, Du Y
2026 Jul 15
置信度 0.82
-
Chondrosarcoma is a heterogeneous group of malignant bone tumors characterized by the production of neoplastic hyaline cartilage. These tumors are often indolent and typically resistant to conventional chemotherapy and radiotherapy, with surgical resection rem…
pubmed
Li L, Bertolet G, Eid JE, Tap WD 等
2026 Jul 27
置信度 0.82
-
Excessive melanin production that results in localized skin darkening is the hallmark of dermal hyperpigmentation, a frequent dermatological disorder. It is primarily induced by ultraviolet exposure, hormonal changes, and inflammatory processes. To develop tar…
pubmed
Ruchitha S, Dalal Y, Singh K
2026 Aug 5
置信度 0.82
-
Cell line misidentification and cross-contamination remain persistent challenges in biomedical research, undermining experimental validity and contributing to irreproducible findings. Despite increased awareness and the availability of authentication technolog…
pubmed
Weiskirchen R
2026 Aug 5
置信度 0.82
-
IntroductionThe Cancer Genome Atlas (TCGA) data has been extensively used for differentially expressed genes (DEGs) discovery and validation in high-grade serous ovarian cancer (HGSOC), however platinum-sensitivity biomarkers have not yet reached clinical appl…
pubmed
Cocchi S, Talijanovic M, Høgdall EV, Lopacinska-Jørgensen J
2026 Jan-Dec
置信度 0.82
-
Scientific advances have expanded cellular therapy beyond its association with stem cell transplantation to include a growing array of products that use a patient's own cells and genetic material to treat disease. Currently.
pubmed
Bell C
2026 Aug 3
置信度 0.82
-
The mutant isocitrate dehydrogenase 1/2 inhibitor (mIDHi) vorasidenib was recently incorporated into clinical treatment guidelines for IDH-mutant gliomas, although its impact on chemoradiation is unclear. Specifically, it is unknown whether upfront mIDHi expos…
pubmed
Shi DD, Calvo Fernández E, Puliyappadamba VT, Lanman TA 等
2026 Aug 5
置信度 0.82
-
Human herpesvirus 7 (HHV-7) encephalitis commonly occurs in immunocompromised individuals and has a poor prognosis. We here reported 3 cases of HHV-7 encephalitis following allogeneic hematopoietic stem cell transplantation (allo-HSCT) with typical neurologica…
pubmed
Ma Y, Cao L, Wang F, Sun H 等
2026 Jan-Dec
置信度 0.82
-
The retinal pigment epithelium (RPE) is crucial for visual function, and its dysfunction contributes to retinal diseases such as age-related macular degeneration. Despite the translational potential of iPSC-derived RPE (iPSC-RPE) in cell replacement therapy, t…
pubmed
Liu X, Tang D, Zhang J, Li T 等
2026 Aug 11
置信度 0.82
-
There is an increasing burden of neurodevelopmental disorders worldwide, with scarce data in low and middle-income countries, including Nigeria. Little is known about Fragile X disorders (Fragile X syndrome and Fragile X premutation-associated conditions) in d…
pubmed
Mbachu CNP, Eseigbe EE, Mbachu II, Eleje GU 等
2026
置信度 0.82
-
Natural killer (NK) cells are key innate effectors during antiviral immune responses, with their activity regulated in part by interactions between polymorphic killer-cell immunoglobulin-like receptors (KIRs) on NK cells and their major histocompatibility comp…
pubmed
Sandstrom K, Hagedorn GN, Robinson SC, Katz JE 等
2026 Aug 5
置信度 0.82
-
Diffuse large B-cell lymphoma (DLBCL) is the most prevalent form of non-Hodgkin lymphoma, exhibiting significant molecular and clinical heterogeneity. Advances in classification integrating phenotypic, genetic, and transcriptomic features have improved diagnos…
pubmed
Pérez-Aguilera M, Pedrosa L, Gómez S, Salazar-Ortego S 等
2026 Sep
置信度 0.82
-
Inborn errors of metabolism (IEM) are a heterogeneous group of genetic disorders characterized by metabolic dysregulation and high mortality. Despite extensive genetic discoveries, the molecular mechanisms underlying severe disease progression remain incomplet…
pubmed
Satria RD, Kusuma RH, Isnani N, Sukorini U 等
2026
置信度 0.82
-
The human immune system is composed of ∼30-50 distinct cell types, each of which can exist in different states of activation or differentiation. Indeed, the mammalian immune system has evolved to sense and respond to infections, cancers, injuries, and c…
pubmed
Lee ME, Kim J, Ionita M, McKeague ML 等
2026 Jul 20
置信度 0.82
-
The blood-brain and blood-tumor barriers impede therapeutic delivery to glioblastoma (GBM). Furthermore, dysfunctional endothelial cells in GBM enable an immunosuppressive tumor microenvironment (TME) and enhance therapeutic resistance. However, the significan…
pubmed
Debski AC, Gorick CM, Breza VR, Tirrell J 等
2026 Aug 5
置信度 0.82
-
Acetylsalicylic acid (ASA, aspirin), derived from salicylic acid in willow bark, is known for its analgesic, anti-inflammatory, and antiplatelet properties. Beyond cardiovascular protection, increasing evidence suggests that ASA may reduce the risk of various …
pubmed
Özerkan D, Durukan S, Koucheki M, Nesil A
2026 Aug
置信度 0.82
-
Over the past decades, the approach to cardiomyopathies has deeply evolved. It has progressively transitioned from one predominantly based on clinical evaluation and conventional imaging towards an integrated and multidimensional approach that incorporates adv…
pubmed
de Boer RA, Chaloupka A, Cowley B, Dominguez F 等
2026 Aug 5
置信度 0.82
-
Post-craniotomy headache (PCH) is a common complication following neurosurgery, yet there remains limited consensus regarding the mechanism, classification, and optimal management. This review summarizes the current literature and highlights recent trends in p…
pubmed
Friedman SA, Nandyala A
2026 Aug 5
置信度 0.82
-
The MEditerranean FeVer (MEFV) gene is a critical regulator of the innate immune response. The prototypical disease related to the MEFV gene is familial Mediterranean fever (FMF). Heterozygous MEFV gene variants have increasingly been reported in association w…
pubmed
Erorhan E, Avar Aydın PÖ, Aydın F, Bahçeci O 等
2026 Aug 5
置信度 0.82
-
The growing use of targeted therapies highlights the need for integrated DNA- and RNA-based next-generation sequencing (NGS) to comprehensively profile tumors. A single-center study was conducted to screen tumor types for which a first-line, integrated DNA-RNA…
pubmed
Destro A, Panebianco F, Durães C, Quagliata L 等
2026 Aug 5
置信度 0.82
-
Hypophosphatasia (HPP) occurs in patients referred for suspected osteoporosis. In our cohort, ALP below 25 IU/L predicted a positive genetic diagnosis, yet higher values did not rule out the clinical diagnosis of HPP. Lower ALP correlated with increased f…
pubmed
Hummel LS, Blaschke M, Lamersdorf A, Lehmann G 等
2026 Aug 5
置信度 0.82
-
Melanoma is an aggressive form of skin cancer characterized by high metastatic potential and increasing incidence and mortality worldwide. Although significant advances have been achieved with immune checkpoint inhibitors and targeted therapies, effective prev…
pubmed
Lanius SL, Pacheco BS, Sousa FSS, Neto ACPS 等
2026 Aug 5
置信度 0.82
-
Phage therapy and phage-antibiotic combinations are promising strategies against multidrug-resistant pathogens like carbapenem-resistant Klebsiella pneumoniae (CRKP). However, the mechanisms underlying phage resistance and the molecular basis of the rational d…
pubmed
Zhu Z, Long T, Wang B, Ding W 等
2026 Aug 5
置信度 0.82
-
Targeted kinase inhibitors induce marked tumor regressions but are limited by the emergence of drug-tolerant residual disease and resistance. Although tumor-intrinsic and adaptive immune mechanisms have been extensively studied, a better understanding of the c…
pubmed
Hsu CH, Chen J, Donahue LR, Lee KJ 等
2026 Aug 5
置信度 0.82
-
BRD7 serves as a critical tumor suppressor, yet it is frequently inactivated via ubiquitination-mediated proteasomal degradation, facilitating tumor progression and metastasis. Although stabilizing or activating BRD7 represents a promising therapeutic strategy…
pubmed
Wei Q, Xue C, Li M, Wei J 等
2026 Aug 5
置信度 0.82
-
Herbal supplements marketed for cognitive and cardiovascular enhancement are widely used, yet safety data remain scarce. Supplement-associated cardiomyopathy is a rare but life-threatening complication that remains underrecognized.
pubmed
Bani Yaseen K, Abdelfattah A, Lataifeh HN, Abuozeid W 等
2026 Aug 5
置信度 0.82
-
In migraine prophylaxis, specific therapeutic options are provided by monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) and its receptor, CGRP receptor antagonists (gepants), and 5-hydroxytryptamine 1F receptor agonist ditans. m…
pubmed
Tajti J, Csáti A, Körtési T, Vécsei L 等
2026 Jul 27
置信度 0.82
-
Migraine is one of the most common types of primary headaches, and its pathomecha nism is not yet fully understood. Our know ledge of its pathophysiology has previously focused primarily on the serotonin system; however, in recent years, increa sing attention …
pubmed
Körtési T, Ajkay-Donáth L, Vágvölgyi-Sümegi E, Tapody Z 等
2026 Jul 27
置信度 0.82
-
Introduction - Glutaric aciduria (or glutaric acidemia) type 1 (GA1) is a rare autosomal recessive neurometabolic disorder caused by mutations in the GCDH gene that results in a deficiency of the glutaryl-CoA dehydrogenase enzyme. It plays a vital role in…
pubmed
Hadady L, Dézsi L, Kalmár T, Szpisjak L 等
2026 Jul 27
置信度 0.82
-
Background - Globoid cell leukodystrophy or Krabbe disease is a rare condition caused by biallelic pathogenic variants in the GALC gene. Accumulation of the metabolic intermedier galactosyl ceramide and psychosine leads to the death of myelin-producing cells. …
pubmed
Sinkó G, Dénes E, Farkas G, Tompa M 等
2026 Jul 27
置信度 0.82
-
Estrogen receptor-positive (ER+), HER2-negative breast cancer is the most common breast cancer subtype. While adjuvant endocrine therapy reduces recurrence risk, identifying which patients benefit from the addition of chemotherapy remains a key clinical challe…
pubmed
Martínez-Pérez C, Tramonti G, Kay C, Taylor KJ 等
2026 Aug 5
置信度 0.82
-
The platelet P2Y 12 receptor plays a critical role in the genesis of arterial thrombotic events. The demonstration of clopidogrel resistance and the relation of high platelet reactivity to ADP to recurrent ischemic event occurrences in patients with coronary a…
pubmed
Gurbel PA, Jeong YH, Navarese E, Kubica J 等
2026 Aug 5
置信度 0.82
-
To investigate the global prevalence of the acrB efflux transporter among antibiotic resistance genes (ARGs) in Klebsiella pneumoniae and to determine how mutations within AcrB drug-binding pockets influence structural stability and antibiotic interactions.
pubmed
Dinata R, Baindara P, Chakraborty S, Mondal S 等
2026 Aug 4
置信度 0.82
-
Manganese-ion-based nanoparticles have emerged as highly versatile platforms that seamlessly integrate diagnostic and therapeutic functions, enabling precision cancer theranostics. In this review, we discuss manganese-based nanomaterials through a design-orien…
pubmed
Li X, Xie W, Jin X, Sun T 等
2026 Aug 5
置信度 0.82
-
Osteoarthritis (OA) is among the leading causes of disability worldwide, yet its pathogenesis remains incompletely understood. Once considered a "non-inflammatory" degenerative disorder, OA is now recognized as a condition driven by chronic low-grade inflammat…
pubmed
Ferrini A, Del Monaco A, Zampogna B, Bosso A 等
2026
置信度 0.82
-
Recurrence-free survival (RFS) following radical prostatectomy is a pivotal measure of therapeutic success in prostate cancer (PCa), yet conventional clinicopathological tools offer limited discriminative accuracy. We sought to construct a platform-independent…
pubmed
He Y, Li B, Tan Z, Jiang K 等
2026
置信度 0.82
-
Sotos syndrome is an autosomal dominant genetic disorder that causes an overgrowth of the body characterized by distinctive craniofacial features, excessive growth, and neurodevelopmental delay. We present a 49-year-old man diagnosed with Sotos syndrome and wi…
pubmed
Hassan A, Ahmed A, Shafi N, Saha U 等
2026 Jul
置信度 0.82
-
Calcium channel blockers (CCBs) show notable interindividual variability in antihypertensive response. This study evaluated the association of a pharmacogenomics (PGx)-guided antihypertensive strategy incorporating CACNA1C rs2238032 and CYP3A5 rs776746 with sh…
pubmed
Deng K, Guo Y, Zhang Y, Qiu H 等
2026
置信度 0.82
-
Alpha-mannosidosis is a rare lysosomal storage disease caused by a deficiency of the enzyme alpha-mannosidase. It manifests as a continuous spectrum of signs and symptoms characterized by dysmorphic features, skeletal abnormalities, delayed psychomotor and spe…
pubmed
Bonilla Fornes S, Mendez Perez MP, Torres Diaz M, Sanchez Gutierrez ME 等
2026 Aug
置信度 0.82
-
Preeclampsia (PE) is a complication of pregnancy characterized by hypertension, with limited therapeutic options and variable treatment response. Identifying novel drug targets is urgently needed.
pubmed
Zhou W, Huang T, Li L, Shen Y 等
2026 Jan-Dec
置信度 0.82
-
Mucopolysaccharidosis type I (MPS-I) is an inherited lysosomal storage disorder characterized by alpha-L-iduronidase deficiency, leading to progressive multi-organ damage and fatal complications. Early treatment is crucial to improve outcomes, particularly in …
pubmed
Nguyen-Ngoc-Quynh L, Can-Thi-Bich N, Dang-Anh D, Dang-Thi H 等
2026 Jan-Dec
置信度 0.82
-
Oncolytic virotherapy (OVT) represents a promising approach for cancer treatment, employing oncolytic viruses (OVs) that selectively infect and lyse tumor cells while promoting an antitumor immune microenvironment. Vaccinia virus (VACV) serves as an attractive…
pubmed
Huang Y, Wang L, Mei S, Zhao F 等
2026
置信度 0.82
-
Severe asthma affects 3%-5% of children and may remain uncontrolled despite high-dose inhaled corticosteroids and other controller therapies. Omalizumab, an anti-IgE monoclonal antibody, is approved for children ≥6 years with severe asthma, however trea…
pubmed
Rottura M, Pirrotta I, Cullotta C, Marino Y 等
2026
置信度 0.82
-
Voriconazole is a first-line therapy for invasive aspergillosis, but its use is complicated by pronounced pharmacokinetic variability, largely driven by CYP2C19 polymorphisms. We aimed to evaluate whether preemptive CYP2C19 genotyping improves early target att…
pubmed
Monserrat-Villatoro J, Bueno D, Estébanez M, Mozo Y 等
2026
置信度 0.82
-
Soft tissue synovial sarcoma is a rare mesenchymal tumor that mainly affects deep soft tissues of the extremities in young adults, but it is also recognized as a primary pulmonary neoplasm. Primary pulmonary synovial sarcoma (PPSS) accounts for less than 0.5% …
pubmed
Mumber S, Kuipers L, Mumber J, Dillmon M 等
2026
置信度 0.82
-
Von Hippel-Lindau (VHL) disease is a rare familial autosomal dominant disorder with an incidence rate of approximately 1 in 36,000. It primarily results from mutations or inactivation of the VHL tumor suppressor gene located on chromosome 3p25-p26. The hallmar…
pubmed
Wang Y, Gao T, Ren N, Liu Y 等
2026
置信度 0.82
-
Pseudomonas aeruginosa is a clinically important opportunistic pathogen in canine otitis externa, particularly in chronic, recurrent or treatment-refractory cases. Its low outer-membrane permeability, biofilm-forming capacity, efflux systems and ability to acq…
pubmed
Veres MA, Tóth ZA, Illés E, Mag P 等
2026
置信度 0.82
-
Adeno-associated virus (AAV) gene transfer vectors mediate long-term expression in nondividing cells, an advantage for treating chronic disorders. However, current platforms lack a way to selectively shut down transgene expression if adverse effects arise. To …
pubmed
de Mulder Rougvie M, Kebret MR, Wu Y, Stiles KM 等
2026 Aug 5
置信度 0.82
-
crossref
J Bagley, J Iacomini
2003-04-11T16:49:27Z
置信度 0.70
-
crossref
2015-10-28T11:44:54Z
置信度 0.70
-
crossref
Thierry VandenDriessche
2009-11-04T08:44:27Z
置信度 0.70
-
crossref
2002-07-26T18:11:26Z
置信度 0.70
-
crossref
Barbara Guinn, Garrett Casey, Sara Collins, Tim O'Brien 等
2008-10-10T09:49:08Z
置信度 0.70
-
crossref
2008-03-20T09:50:38Z
置信度 0.70
-
Gene therapy aims to treat genetic diseases by introducing genetic material into cells to correct medical conditions or enhance health. This involves using nucleic acids, viruses, or genetically modified microorganisms to integrate therapeutic genetic material…
crossref
Diclehan Oral
2024-10-03T02:33:05Z
置信度 0.70
-
crossref
2002-07-26T18:08:35Z
置信度 0.70
-
crossref
Natasha J. Caplen
2011-11-17T19:51:54Z
置信度 0.70
-
crossref
PR Lowenstein
2003-12-18T09:02:26Z
置信度 0.70
-
crossref
Lihua Peng
2018-05-03T16:16:33Z
置信度 0.70
-
crossref
Jerzy Trojan
2012-03-29T04:36:02Z
置信度 0.70
-
crossref
Stefan Kochanek
2002-07-26T18:11:26Z
置信度 0.70
-
crossref
W. French Anderson
2002-07-26T18:08:44Z
置信度 0.70
-
crossref
2008-06-12T21:09:11Z
置信度 0.70
-
crossref
R Wolkowicz, G P Nolan
2005-02-10T10:10:02Z
置信度 0.70
-
crossref
Soosan Ghazizadeh, Lorne B. Taichman
2002-07-26T18:05:48Z
置信度 0.70
-
crossref
2024-09-24T17:46:03Z
置信度 0.70
-
crossref
2020-11-12T21:45:38Z
置信度 0.70
-
crossref
Nejat Düzgüneş
2016-03-23T11:47:17Z
置信度 0.70
-
crossref
2016-03-23T07:47:17Z
置信度 0.70
-
crossref
Changqing Su
2012-03-29T04:32:32Z
置信度 0.70
-
crossref
Paul Tolstoshev
2008-06-12T20:25:19Z
置信度 0.70
-
crossref
Jonathan C. Vogel
2002-07-26T18:08:44Z
置信度 0.70
-
crossref
2008-03-20T00:45:21Z
置信度 0.70
-
crossref
2020-11-12T16:45:38Z
置信度 0.70
-
crossref
S H Cheng, A E Smith
2003-07-28T11:48:55Z
置信度 0.70
-
crossref
2016-12-16T17:30:01Z
置信度 0.70
-
crossref
2013-06-25T16:15:21Z
置信度 0.70
-
The idea of treating disease in humans with genetic material was conceived over two decades ago and with that a promising journey involving development and efficacy studies in cells and animals of a large number of novel therapeutic reagents unfolded. In the f…
crossref
Thomas J. Corydon
2015-07-29T14:35:05Z
置信度 0.70
-
crossref
JJ Min, SS Gambhir
2004-01-08T08:44:01Z
置信度 0.70
-
crossref
2008-06-13T07:59:12Z
置信度 0.70
-
crossref
Fred D. Ledley
2018-09-04T01:56:41Z
置信度 0.70
-
crossref
R. Engler
2013-12-29T21:51:41Z
置信度 0.70
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80
-
europepmc
2026
置信度 0.80