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• Comparative Evaluation of Adaptive Focused Acoustics- and SP3-Based Workflows for Deep Proteomic Profiling of 30-Year-Old Formalin-Fixed Paraffin-Embedded Tissues.
  Formalin-fixed paraffin-embedded (FFPE) tissues represent a vast archive for translational research that offers access to specimens with clinical outcomes. However, formalin-induced crosslinking hinders efficient protein extraction and limits proteomic applica…
  pubmed Noguchi R, Ishii M, Adachi Y, Yoshimatsu Y 等 2026 Aug 6 置信度 0.82
• Promoter-Level Regulation of Melatonin Biosynthesis in Plant Stress Responses: A Framework for Climate-Resilient Crop Improvement.
  Climate change increasingly exposes crops to overlapping abiotic and biotic stresses, creating a need for regulatory strategies that improve stress tolerance without imposing unnecessary fitness costs under favorable conditions. Melatonin has been widely assoc…
  pubmed Khan MHU, Muhammad A, Li L, Zhang D 等 2026 Sep 置信度 0.82
• Gastrointestinal manifestations of common variable immunodeficiency: what a gastroenterologist needs to be aware of.
  Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency disorder and, given its predilection to affect the gastrointestinal (GI) tract, will be encountered in the practice of a general gastroenterologist, as wel…
  pubmed Levy DM, Meriwether M, Schwartz MR, Bishu S 等 2026 Aug 6 置信度 0.82
• Integrative Bioinformatics Approaches in Environmental Biotechnology: A Review.
  Environmental biotechnology increasingly relies on bioinformatics to address global challenges in pollution control or degradation, biodiversity conservation, and sustainable resource management. By integrating genomics, computational tools, and artificial int…
  pubmed Teklay YT 2026 置信度 0.82
• Mössbauer spectroscopy in drug discovery: revealing Fe- and Fe-S cluster dependent targets.
  Iron- and iron-sulfur cluster (Fe-S)-containing proteins are essential for diverse biological processes, including electron transfer, genome maintenance, metabolism, cellular signaling, and host-pathogen interactions. Despite their broad biological importance …
  pubmed Chen J, Quist T, Fang R, Nguyen HT 等 2026 Aug 5 置信度 0.82
• Optical genome mapping enhanced by refined variant interpretation in pediatric acute lymphoblastic leukemia.
  Reliable detection of structural variants (SVs) and copy number variations (CNVs) is crucial in the contemporary diagnostics of pediatric B-cell acute lymphoblastic leukemia (B-ALL). However, limitations of commonly used conventional and molecular cytogenetic …
  pubmed Bekő A, Péterffy B, Hughes A, Jakab JS 等 2026 Aug 5 置信度 0.82
• Identifying causal genetic markers and cellular mechanisms in diabetic retinopathy through single-cell sc-eQTL analysis and Mendelian randomization.
  Diabetic retinopathy (DR) requires robust biomarkers. To overcome the limitations of bulk sequencing, we integrated single-cell eQTL mapping with Mendelian randomization to identify causal cell populations and genes. CD8 Teff cells were expanded in peripheral …
  pubmed Cao L, Wang Z, Cai X, Zhou Y 等 2026 Aug 5 置信度 0.82
• Rare Heterozygous Loss-of-Function Variants in MCOLN1 Identified in Two Sporadic Patients with α-Synucleinopathies.
  Growing evidence links lysosomal dysfunction to parkinsonism. TRPML1, a lysosomal cation channel encoded by the MCOLN1 gene, is essential for lysosomal function. Biallelic loss-of-function variants in MCOLN1 cause mucolipidosis type IV. However, the role of he…
  pubmed Ying C, Chen X, Cen Z, Feng X 等 2026 Aug 5 置信度 0.82
• Computed Tomography and Plasma Proteomics for Early Discrimination of Post-Pancreatitis Diabetes Mellitus.
  BACKGROUND There is a lack of effective predictive methods for post-pancreatitis diabetes mellitus (PPDM-A) in clinical practice. This exploratory study aimed to identify candidate computed tomography (CT) and plasma proteomic features associated with subseque…
  pubmed Hu R, Zeng X, Li G, Ma J 等 2026 Aug 6 置信度 0.82
• Genetic Defects in the Sperm Tail: Damaged Radial Spokes and Male Infertility.
  Male infertility is a global reproductive health issue, and sperm from the majority of infertile males exhibit motility defects. Although anatomical and endocrinological etiologies underlying male infertility have been identified and become targets for clinica…
  pubmed Lee JY, Hwang JY 2026 Jul 24 置信度 0.82
• Compound Heterozygous Mutations in DCLRE1C Caused Leaky SCID Phenotype.
  pubmed Lapidus T, Lev A, Barel O, Somech R 2026 Aug 置信度 0.82
• Bone Marrow Failure Syndromes: Clinical and Genetic Characterization in TERT-associated Dyskeratosis Congenita.
  Bone marrow failure syndromes (BMFs) comprise a heterogeneous group of genetic disorders characterized by impaired hematopoiesis and multisystem involvement. Dyskeratosis congenita (DC) is a telomere biology disorder caused by defects in telomerase or telomere…
  pubmed Somekh I, Mandola AB, Frizinsky S, Lev A 等 2026 Aug 置信度 0.82
• Extended-Spectrum Beta-Lactamase (ESBL)-Producing E. coli in Livestock and Free-Roaming Wildlife: A Combined Phenotyping-Whole-Genome Sequencing One Health Approach.
  Antimicrobial resistance (AMR) in Enterobacterales, particularly extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec), poses a significant public health concern. Widespread antimicrobial use exerts selection pressure, driving the persistence a…
  pubmed Conforti S, Kapopoulou A, Bank C, Köchle B 等 2026 置信度 0.82
• Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).
  During long-term artificial selection, China has developed indigenous dairy goat populations with breed-specific traits and environmental adaptability. However, the genetic relationships and genomic characteristics of these populations remain insufficiently st…
  pubmed Xiong J, Shang M, Bao J, Liu T 等 2026 Aug 6 置信度 0.82
• Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics.
  Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigatio…
  pubmed Zhang D, Ding Y, Kang W, Zhu X 等 2026 Aug 5 置信度 0.82
• A comparative mutation-selection reanalysis of colon and rectal adenocarcinoma highlights PIK3CA variants and BRAF V600E.
  pubmed Ke L, Cecchini M, Townsend JP 2026 Aug 5 置信度 0.82
• Retraction Note: Development and validation of genomic and epigenomic signatures associated with tumor immune microenvironment in hepatoblastoma.
  pubmed Zhang Y, Zhang T, Yin Q, Luo H 2026 Aug 5 置信度 0.82
• Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.
  Recent genetic findings have broadened the perspectives of cluster headache pathophysiology. Genes identified by genome wide association studies are likely to be involved in the pathophysiological mechanisms underlying the disease. In this study, we performed …
  pubmed Ran C, Deborgies Sanches C, Swedblom J, Wellfelt K 等 2026 Aug 4 置信度 0.82
• Genomic characteristics and geographical distribution of uncultivated soil prokaryotes.
  Most soil prokaryotic species remain uncultivated, limiting our understanding of the terrestrial microbiome. Metagenomic sequencing, and particularly the study of metagenome-assembled genomes (MAGs), represents an unprecedented opportunity to characterize the …
  pubmed Rodríguez Del Río Á, Cui Y, Mansour I, Rillig MC 2026 Aug 4 置信度 0.82
• Urban green roofs host intrinsic resistomes shaped by management but not dominated by pathogenic resistance.
  Urban green roofs are increasingly introduced to enhance urban biodiversity and ecosystem services, yet their role in shaping antimicrobial resistance in cities remains unclear. Using long-read metagenomic sequencing, we characterized antimicrobial resistance …
  pubmed Martínez-Cuesta R, Craighero A, Walch S, Helmreich B 等 2026 Aug 6 置信度 0.82
• Systematic prioritization of candidate genes in camptothecin biosynthesis using multi-omics and deep learning.
  Camptothecin (CPT), a plant-derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering …
  pubmed Wang S, Wu X, Moreno M, Oh J 等 2026 Sep 置信度 0.82
• Protective or Therapeutic Effect of Exosomes Isolated From Mesenchymal Stem Cells on Cisplatin-Induced Ovarian Damage.
  Cisplatin (Cis), an index drug with the greatest gonadotoxic potential, affects both primordial follicles and developing follicles (pre-antral) in vivo. Mesenchymal stem cell-derived exosomes accelerate cell proliferation and wound healing. Exosomes have …
  pubmed Yay A, Gonen ZB, Kalkan KT, Yalcın B 等 2026 Aug 5 置信度 0.82
• Diurnal dynamics of maize gene expression is associated with phyllosphere microbiome composition.
  Bacterial communities play important roles in the plant phyllosphere. Both microbial communities and their hosts exhibit endogenous circadian rhythms while simultaneously responding to environmental changes across the diurnal cycle. However, the interaction be…
  pubmed Dos Santos RAC, Hidalgo-Martinez K, Muñoz-Perez JM, Laspisa DJ 等 2026 Aug 6 置信度 0.82
• Neanderthal gene makes some modern humans taller and more muscular.
  pubmed Basu M 2026 Aug 5 置信度 0.82
• Maps of chromosomal regions crucial for cell division reveal high diversity.
  pubmed 2026 Aug 5 置信度 0.82
• Discovery and mapping of a new gene in wheat for race-specific adult plant resistance to Puccinia striiformis f. sp. tritici.
  Key message A non-durable adult plant stripe rust resistance gene in wheat was mapped to the distal region of chromosome 2DS and designated Yr88. Wheat stripe (yellow) rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most damaging funga…
  pubmed Park RF, Chhetri M, Sandhu KS, Ziems L 等 2026 Aug 5 置信度 0.82
• Identifying marker-trait associations for wheat stem sawfly resistance.
  Two novel WSS resistance loci were identified on chromosomes 2B and 5A. Characterization of WSS resistance loci will improve breeders' ability to select to reduce yield loss due to WSS. Wheat stem sawfly (WSS) is a native grass feeding pest of winter wheat (Tr…
  pubmed Hammers M, Winn ZJ, Rice B, Nachappa P 等 2026 Aug 5 置信度 0.82
• GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.
  There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present g…
  pubmed Jolma A, Hernandez-Corchado A, Yang AWH, Fathi A 等 2026 Aug 5 置信度 0.82
• Genetic interactions between PIWI subfamily genes and hobo transposons modulate Drosophila melanogaster lifespan under chronic low-intensity irradiation.
  In recent decades, there has been active research into how ionizing radiation at low doses, an inevitable factor in human activity, affects aging processes and which molecular genetic mechanisms underlie this influence. This study investigates the effects of m…
  pubmed Yushkova E 2026 Aug 5 置信度 0.82
• Integrating clinically actionable biomarkers into bladder cancer care - recommendations from the International Bladder Cancer Group.
  Crucial unmet needs for standardization and clinical integration of actionable biomarkers persist across the bladder cancer disease spectrum. To address these gaps, the International Bladder Cancer Group (IBCG) convened a global multidisciplinary panel to deve…
  pubmed Hensley PJ, Teoh JYC, Li R, Gupta S 等 2026 Aug 5 置信度 0.82
• The role of genetic variation in apolipoprotein response to diet among Brazilians with cardiovascular disease.
  Data on the interaction between dietary patterns, single nucleotide polymorphisms (SNPs), and cardiometabolic markers remain limited in genetically admixed populations, particularly among individuals with established cardiovascular disease (CVD). This study ai…
  pubmed Bersch-Ferreira AC, Santos RHN, Rogero MM, Machado RHV 等 2026 Aug 5 置信度 0.82
• MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA.
  The oncoprotein MDM2 is widely recognized as the principal negative regulator of p53, thereby controlling the expression of numerous RNA polymerase II (Pol II)-dependent genes involved in cell cycle arrest and apoptosis. Beyond this canonical role, MDM2 also e…
  pubmed Weber S, Manzini V, Dietrich H, Schotte H 等 2026 Aug 6 置信度 0.82
• Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice.
  Non-typhoidal Salmonella use molybdenum cofactor-containing MopB- or DMSO reductase-family members to respire chemically diverse substrates, including formate, nitrate and methionine sulfoxide, during infection. The DmsABC enzymatic complex encodes one such DM…
  pubmed Kim JS, Uppalapati S, Margolis A, McClelland M 等 2026 Aug 5 置信度 0.82
• IL-1 family signalling drives mucosal defence against systemic Candida albicans infection.
  Candida albicans is a major opportunistic pathogen in humans that is capable of breaching mucosal barriers and causing severe systemic infections with high mortality. How the host controls mucosal infection and prevents dissemination remains unclear but is ess…
  pubmed Griffiths JS, Kempf A, Pickering RJ, Priest EL 等 2026 Aug 5 置信度 0.82
• Detecting pathogenic structural variation in families with undiagnosed rare disease in a national genome project.
  Whole-genome sequencing (WGS) projects for rare disease diagnosis typically yield a diagnostic rate of 25-41%, depending on the methods for patient selection and the extent of prior genetic testing. The Scottish Genomes Partnership (SGP) is a collaborative pro…
  pubmed Dutta P, Pagnamenta AT, Robert C, McGuigan AEF 等 2026 Aug 5 置信度 0.82
• Patients' and parents' views on how digital tools enable personalized and partnered care in genetics: a qualitative study.
  Patient-facing digital tools in genetics can increase efficiency and personalize care, but may threaten patient-provider relationships due to a diminished sense of connection associated with traditional face-to-face encounters. To learn about experiences with …
  pubmed Assamad D, Saeedi S, Grewal S, Jha V 等 2026 Aug 5 置信度 0.82
• Editorial Expression of Concern: Tumour exosome integrins determine organotropic metastasis.
  pubmed Hoshino A, Costa-Silva B, Shen TL, Rodrigues G 等 2026 Aug 5 置信度 0.82
• Publisher Correction: Progressive plasticity during colorectal cancer metastasis.
  pubmed Moorman A, Benitez EK, Cambuli F, Jiang Q 等 2026 Aug 5 置信度 0.82
• An expanded codebook of human transcription factor DNA-binding specificity.
  Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs 1 . Furthermore, even for well-charact…
  pubmed Jolma A, Laverty KU, Fathi A, Yang AWH 等 2026 Aug 5 置信度 0.82
• Uncovering the mechanism of female restitution in sugarcane hybrids.
  Variations of meiosis, which normally halve genetic complements prior to fertilization, can have profound consequences. For example, whole-genome duplications (polyploidy) have shaped the evolution and diversification of most angiosperm lineages. The century-l…
  pubmed Zhu S, Tang H, Jones T, Fumia N 等 2026 Aug 5 置信度 0.82
• A tumour-derived organoid biobank maps cancer gene dependencies.
  Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient t…
  pubmed Herranz-Ors C, Bhosle SG, Beck AE, Gilbert JGR 等 2026 Aug 5 置信度 0.82
• A compendium of next-generation patient-derived models for diverse cancers.
  The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2-4 . Recent technologies …
  pubmed ElHarouni D, Al-Jazrawe M, Choi S, Dede M 等 2026 Aug 5 置信度 0.82
• A dependency map enhanced with next-generation 3D cancer models.
  Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer 1 . The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical …
  pubmed Neiswender JV, Maffa S, Brenan L, ElHarouni D 等 2026 Aug 5 置信度 0.82
• Task geometry alignment enables parameter independent and accurate genomic search.
  Standard sequence alignment models biological homology through the metric space of edit distance. While effective for global orthology, this rigid geometric assumption struggles with discrete biological realities-such as insertions/deletions (indels) and fragm…
  pubmed Boone J 2026 Aug 5 置信度 0.82
• Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations.
  Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relati…
  pubmed Poh AR, Sexton A, Pietrzak H, De Losa R 等 2026 Aug 3 置信度 0.82
• Extensive binding of poorly characterized human transcription factors to genomic dark matter.
  The functional impact of a large portion of the human genome known as "dark matter DNA", which is composed mainly of repeat sequences, remains unknown. The genome also encodes many putative and poorly characterized transcription factors. Here, we determine gen…
  pubmed Razavi R, Fathi A, Yellan I, Brechalov A 等 2026 Aug 5 置信度 0.82
• Farming practices exert selection pressures on the resistome of natural populations of house mice.
  The factors maintaining antimicrobial resistance genes (ARGs) in non-domesticated animal microbiomes remain unclear for species inhabiting human-dominated or less human-impacted landscapes. We analysed 875 gut metagenomes from natural populations of house mice…
  pubmed Gicquel M, Planillo A, Heitlinger E, Forslund-Startceva SK 等 2026 Aug 5 置信度 0.82
• Identification of methylation-sensitive human transcription factors using meSMiLE-seq.
  Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed …
  pubmed Gralak AJ, Faltejskova K, Yang AWH, Steiner C 等 2026 Aug 5 置信度 0.82
• Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis.
  Genetic mapping is a powerful tool for eukaryotic genetics that has only been applied to bacteria in limited circumstances. Quantitative trait locus (QTL) mapping generally relies on sexual recombination to break linkages between genes, yet bacteria rarely und…
  pubmed Vasileva DP, Chhetri HB, Hochanadel LH, Streich JC 等 2026 Aug 5 置信度 0.82
• The Novel HLA-A Allele, HLA-A*26:269Q, Was Identified in a Bone Marrow Donor.
  The HLA-A*26:269Q allele is characterized by next-generation sequencing in a healthy individual from the Russian bone marrow Registry.
  pubmed Loginova M, Morozova N, Paramonov I 2026 Aug 置信度 0.82
• Parent-child connectedness and its associations with sexual risk behavior and outcomes among young people: a systematic review and meta-analysis.
  Significant disparities in the sexual and reproductive health of young people persist globally. Although previous systematic reviews and meta-analyses have largely focused on the effects of parenting practices, such as parent-child communication and parental m…
  pubmed RenChen X, Wu B, Dang Z 2026 Aug 17 置信度 0.82
• Air pollution and rheumatoid arthritis disease activity: linking pathogenesis and progression.
  pubmed Sparks JA 2026 Aug 5 置信度 0.82
• Antibacterial and antibiofilm activities of Zn(2+) against Staphylococcus aureus and Streptococcus mutans.
  Staphylococcus aureus (S aureus) and Streptococcus mutans (S mutans) are pathogenic bacteria associated with denture-related stomatitis. Zinc (Zn), a widely used metallic antibacterial agent, can induce the production of reactive oxygen species (ROS) in cells,…
  pubmed Shu F, Wang Z, Chen W, Liu M 2026 Aug 5 置信度 0.82
• A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice.
  Cerebellar Purkinje cells (PCs) exhibit a unique and highly complex dendritic architecture, which plays a crucial role in integrating synaptic inputs and shaping their physiological properties. However, fine morphological investigation of PCs at the single-cel…
  pubmed Tan X, Niu S, Bai M, Megagiannis P 等 2026 Aug 5 置信度 0.82
• Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei.
  An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configurati…
  pubmed Liu YH, Hsu CK, Zheng LG, Chien SY 等 2026 置信度 0.82
• Medication Use in Pregnancy/Lactation and Neonates: Threading the Needle.
  pubmed Davis JM, Norwitz ER 2026 Sep 置信度 0.82
• Omission of Axillary Surgery for Low-Risk Breast Cancer.
  Landmark trials have demonstrated that residual microscopic disease in the undissected axilla does not translate to a higher risk of nodal recurrence, which laid the groundwork for trials examining the omission of axillary surgery. The SOUND and INSEMA randomi…
  pubmed Pawloski KR, Barrio AV 2026 Sep 置信度 0.82
• Exploration of SOCS3 and HSPA1A in PANoptosis during acute myocardial infarction and chronic kidney disease.
  Chronic kidney disease (CKD) is an independent risk factor for acute myocardial infarction (AMI), but the mechanisms underlying their comorbidity remain unclear. As a newly described inflammatory form of programmed cell death, PANoptosis may play a key role. T…
  pubmed Liu G, Xian H, Xu Y, Ma J 等 2026 置信度 0.82
• A mini review of genome-predicted β-lactam susceptibility in Streptococcus pneumoniae: from PBP profiles to potential clinical interpretation.
  β-Lactams remain central to the treatment of pneumococcal infections, and whole-genome sequencing increasingly enables pneumococcal β-lactam susceptibility to be inferred from the combined transpeptidase-domain sequences of PBP1a, PBP2b, and PBP2x.…
  pubmed Yan Z, Liu L, Ren Y, Ling J 等 2026 置信度 0.82
• Splenectomy revisited in Wiskott-Aldrich syndrome in the era of HSCT and gene therapy: a bridge, a rescue, or simply obsolete?
  Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by mutations in the WAS gene, classically presenting with microthrombocytopenia, eczema, and recurrent infections, with an incidence of approximately 1 per 100, 000 live births. …
  pubmed Khanafer Y, Al-Naemi A, Khayyat L, Cyprian F 2026 置信度 0.82
• Case Report: Refractory desmoplastic small round cell tumor: a report of a molecularly confirmed case with EWSR1-WT1 fusion.
  Desmoplastic small round cell tumor (DSRCT) is an extremely rare and highly aggressive soft-tissue sarcoma that predominantly affects adolescents and young male patients. This malignancy is defined by the t(11;22) (p13;q12) chromosomal translocation, which gen…
  pubmed Li N, Jiang J, Tan F, Deng Q 2026 置信度 0.82
• Case Report: Five-year follow-up of leptomeningeal transthyretin amyloidosis (Ala45Thr) with CNS involvement under tolcapone therapy.
  Transthyretin (TTR) p.Ala45Thr variant is pathogenic, typically associated with cardiomyopathy and peripheral neuropathy. Leptomeningeal and central nervous system (CNS) involvement is rare, and longitudinal treatment data remain limited.
  pubmed Giedraitienė N, Preikšaitienė E, Klimašauskienė A 2026 置信度 0.82
• FBN1 TB5 domain variants in acromelic dysplasia: multisystem manifestations, genotype-phenotype correlations, and partial responses to growth hormone therapy.
  Acromelic dysplasias, including acromicric dysplasia (AD) and geleophysic dysplasia type 2 (GD2), are ultrarare disorders caused by FBN1 variants in the transforming growth factor-β-binding protein-like domain 5 (TB5). These conditions are characterized …
  pubmed Zhang J, Huang MT, Wang B, Lin YY 等 2026 置信度 0.82
• Analysis of Clinical Characteristics and Risk Factors of Pediatric Macrolide-Resistant Mycoplasma pneumoniae Pneumonia from 2023 to 2025: A Single-Center Retrospective Study.
  Since 2023, re-emerging Mycoplasma pneumoniae (MP) with high macrolide resistance has challenged pediatric care.
  pubmed Yan L, Zhang H, Fu H, Dong H 等 2026 置信度 0.82
• Microbiota in cholestatic diseases: crosstalk among bile composition, the biliary microbiome, and host immunity.
  Cholestatic liver diseases are a heterogeneous group of hepatobiliary disorders caused by impaired bile formation, secretion, or excretion, leading to hepatocyte injury, biliary inflammation, fibrosis, and eventually cirrhosis. Traditional studies have largely…
  pubmed Yang Y, Ren L, Zhang Y, Wang X 等 2026 置信度 0.82
• Heteroresistance in Mycobacterium tuberculosis: from molecular mechanisms and advanced detection to clinical implications.
  Drug resistance in Mycobacterium species, particularly Mycobacterium tuberculosis , remains a protracted and severe challenge to global public health. Recent studies have revealed that heteroresistance, serving as a critical precursor stage to full resistance,…
  pubmed Liu S, Chen D, Zhang J, Zhu M 2026 置信度 0.82
• Potent Inhibition of Dengue Virus Infection by Synthetic Compound TXD-174 Through Specific Targeting of IL-24.
  Dengue virus (DENV) infection has emerged as a critical global public health challenge, particularly in tropical and subtropical regions, where it continues to cause high morbidity rates and severe disease risks. Given the current lack of specific antiviral th…
  pubmed Han J, Kong W, Guo D, Liu S 等 2026 Aug 置信度 0.82
• Oral Rosiglitazone Supplementation Mitigates Pulmonary Cellular Stress Response During Lipopolysaccharide-Evoked Acute Lung Injury in Mice.
  Cellular stress is implicated in the progression of lipopolysaccharide (LPS)-evoked acute lung injury (ALI). The goal of this study was to evaluate the effect of oral supplementation with rosiglitazone (RSG), which is an agonist of peroxisome proliferator-acti…
  pubmed Wei JP, Cao W, Liu ZF, Liu Z 等 2026 置信度 0.82
• Sappanwood extract modulates hepatic structure-function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia.
  Hepatomegaly in hemolytic disorders, including in thalassemia, is a common complication, primarily due to hemosiderosis and activation of extramedullary hematopoiesis. Globin chain imbalance leads to chronic hemolysis and ineffective erythropoiesis, which are …
  pubmed Pratama MI, Safitri R, Malini DM, Syamsunarno MRAA 等 2026 Aug 5 置信度 0.82
• The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy.
  Gastric cancer (GC) remains a major health burden because of late-stage diagnosis and resistance to systemic therapy.
  pubmed Liu G, Li P, Li Z, Li J 等 2026 Aug 置信度 0.82
• Tricho-Hepato-Enteric Syndromic Immunodeficiency: Clinical Spectrum, Pathobiology, and Emerging Therapies.
  Syndromic inborn errors of immunity (IEIs) are a heterogeneous group of disorders characterized by immune dysfunction associated with congenital anomalies and multisystem involvement. Tricho-hepato-enteric syndrome (THES) is an ultra-rare autosomal recessive s…
  pubmed Mandola AB, Frizinsky S, Somekh I, Naor S 等 2026 Aug 置信度 0.82
• [Approach to the Patient with Polycythemia].
  Polycythemia is defined as an elevation of age and sex - adjusted hematocrit. While Polycythemia vera (PV) is a myeloproliferative neoplasm caused by JAK2 mutations leading to an autonomous proliferation of red blood cells. Most cases of polycythemia seen in g…
  pubmed Leviatan I, Ellis M 2026 Jul 置信度 0.82
• Assessment of Trophoblast cell surface antigen 2 (Trop-2) expression and its clinical significance in breast cancer: a multi-level analysis of protein and gene expression.
  Trophoblast cell surface antigen 2 (Trop-2) is a targetable transmembrane glycoprotein commonly overexpressed in breast cancer (BC). This study combines a systematic review and meta-analysis with a retrospective analysis of an independent early BC patient coho…
  pubmed Toli MA, Sarafidis M, Filis P, Tzoras E 等 2026 Jul 31 置信度 0.82
• The tumour microenvironment influences long-term tamoxifen benefit in postmenopausal ER+/HER2- breast cancer patients: a secondary analysis of the randomised Stockholm Tamoxifen (STO-3) trial.
  The tumour microenvironment (TME) influences breast cancer progression and treatment response. We investigated whether TME composition predicts tamoxifen benefit in postmenopausal women with oestrogen receptor-positive, HER2-negative (ER+HER2-) breast cancer.
  pubmed Camargo-Romera P, Castresana-Aguirre M, Danielsson O, Dar H 等 2026 Aug 5 置信度 0.82
• Indirect bilirubin mitigates tubular vacuolization and injury in experimental contrast nephropathy.
  Contrast-associated acute kidney injury (CA-AKI) remains a clinically relevant complication of intravascular contrast media use, involving complex and incompletely understood mechanisms including oxidative stress, inflammation, apoptosis, and vasomotor dysregu…
  pubmed Ünal F, Selçuk MT, Ece S, Karabulut Ş 等 2026 Aug 5 置信度 0.82
• [Multiple endocrine neoplasia presenting initially as acute pulmonary thromboembolism: a case report].
  We reported a rare case in which acute pulmonary thromboembolism (APTE) was the initial clinical manifestation of multiple endocrine neoplasia type 1 (MEN1). A 44-year-old male presented with chest tightness and dyspnea, and was subsequently diagnosed with acu…
  pubmed Zhang HP, Deng H, Aili A, Pan L 等 2026 Aug 12 置信度 0.82
• Clinical and genomic determinants of extraordinary response and resistance to androgen receptor pathway inhibitors in men with metastatic androgen pathway modulator sensitive (APMS) prostate cancer.
  Identifying clinical and genomic predictors of response to androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPI) for metastatic androgen pathway modulator sensitive (APMS) prostate cancer is essential for improving therapeutic deci…
  pubmed McKenzie J, Howard L, Park JJ, Ashraf B 等 2026 Aug 5 置信度 0.82
• Genomic surveillance reveals co-occurrence of Plasmodium falciparum drug resistance variants across diverse transmission settings in Ethiopia.
  The emergence of antimalarial drug resistance threatens malaria control and elimination efforts in Africa. Ethiopia, once a success story in case reduction, is now experiencing a resurgence. Here we examine key drug resistance genes (Pfmdr1, Pfcrt, Pfk13, Pfdh…
  pubmed Letebo A, Vanheer LN, Engdaw M, Ejigu LA 等 2026 Aug 5 置信度 0.82
• Membranolytic peptide programs immunogenic cell death for cancer therapy.
  A rational design for facilitating innovative cell death modes can substantially aid advances in antitumour therapy 1,2 . Here we design and implement a unique mode of immunogenic membranolytic cell death (mLCD) in tumour cells, characterized by time-lagg…
  pubmed Yuan Y, Liang L, Li J, Li C 等 2026 Aug 5 置信度 0.82
• Stimulation modulates gene-linked cell assemblies in the human brain.
  Reshaping cortical circuits through stimulation represents an emerging therapy for the restoration of cognitive function 1-5 , yet the biological mechanisms that underlie its effects remain largely unexplored in humans. Here, to directly investigate the mechan…
  pubmed Moore H, Dehnad M, Freelin A, Granger B 等 2026 Aug 5 置信度 0.82
• Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8.
  Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour-stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, th…
  pubmed Qian J, Tan Z, Wang J, Wei T 等 2026 Aug 5 置信度 0.82
• TET2-driven demethylation of ANG promotes angiogenesis and malignant transformation in oligodendroglioma.
  Oligodendrogliomas (OG) are indolent yet inevitably progressive gliomas in which angiogenesis is tightly linked to malignant transformation, but the underlying epigenetic mechanisms remain unclear. By integrating public datasets of primary and malignant transf…
  pubmed Jin J, Yuan Z, Wu H, Wei Y 等 2026 Aug 5 置信度 0.82
• Novel highly selective ROCK2 inhibitor (TDI01) for the treatment of chronic graft-versus-host disease: a multicenter, open-label phase Ib/II study.
  Chronic graft-versus-host disease (cGVHD) remains a major complication following allogeneic hematopoietic stem cell transplantation for long-term survival. Emerging evidence highlights Rho-associated coiled-coil kinase 2 (ROCK2) as a promising therapeutic targ…
  pubmed Mo X, Zhang X, Guo R, Jiang E 等 2026 Aug 6 置信度 0.82
• Emerging imipenem resistance in Nocardia infections in Taiwan: a retrospective cohort study at a tertiary teaching hospital.
  Nocardia species are emerging pathogens of increasing significance, particularly in immunocompromised hosts. Due to diverse clinical manifestations and resistance patterns, accurate identification is critical. This study characterized species distribution in T…
  pubmed Jhou DW, Yang CY, Lao CK, Chen NY 等 2026 Aug 4 置信度 0.82
• [Clinical characteristics, treatment and prognostic influencing factors in patients with dermatomyositis positive for anti-melanoma differentiation-associated gene 5 antibody].
  Objective: To explore the clinical characteristics, efficacy and safety of different therapeutic regimens in patients with anti-MDA5 antibody positive dermatomyositis (anti-MDA5⁺DM) stratified by disease risk, and to analyze the influencing factors for …
  pubmed Xu XD, Mo HY, Zhao C, Wen J 等 2026 Aug 1 置信度 0.82
• Diet and Atherosclerosis Prevention: Rethinking the Significance of "The Japan Diet".
  Although the mortality rate from cardiovascular disease (CVD) in Japan remains lower than that in Western countries, the need for the prevention of atherosclerotic diseases still merits emphasis. Cardiovascular disease develops due to the accumulation of risk …
  pubmed Maruyama C 2026 Aug 6 置信度 0.82
• Rheumatological mimic: primary hypertrophic osteoarthropathy initially treated as juvenile idiopathic arthritis.
  Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder that closely mimics inflammatory arthritis, leading to diagnostic delays and inappropriate treatment. We report the case of an adolescent boy who presented with a 2-year history of intermit…
  pubmed Kumawat R, Upadhyaya SK, Arora D 2026 Aug 5 置信度 0.82
• Loss of NCCRP1 overcomes immune evasion in lung adenocarcinoma.
  The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying mechanisms remain elusive. Here we identify non-spe…
  pubmed Liu L, Qi S, Shao L, Cai J 等 2026 Aug 5 置信度 0.82
• Heme-induced kallikrein-kinin system activation in hemolytic uremic syndrome.
  Heme is released from red blood cells during hemolytic uremic syndrome (HUS). Here, we investigated hemolysis-induced kallikrein-kinin system activation and the interaction between heme and clotting factor XII (FXII).
  pubmed Gerogianni A, Friberg N, Wendler M, Kellnerova S 等 2026 Aug 5 置信度 0.82
• Endocrine-disrupting chemical-induced gene networks confer coronary heart disease risk revealed by causal inference and single-cell analyses.
  Endocrine-disrupting chemicals (EDCs) are linked to coronary heart disease (CHD), but underlying mechanisms remain unclear. We aimed to identify EDC-related genes and evaluate their causal roles in CHD.
  pubmed Yao T, Lin YL, Fang LX, Wang YT 等 2026 Aug 5 置信度 0.82
• Rethinking hemocompatibility standards: a critical appraisal of current regulatory frameworks for Advanced Therapy Medicinal Products (ATMPs) validation.
  Hemocompatibility, defined as the ability of a product to interact safely with blood components, is a critical requirement for therapies intended for intravascular administration. Current evaluation frameworks, primarily based on ISO 10993-4:2017, were initial…
  pubmed Bouarroudj H, Gillot C, Cnop M, Dogné JM 等 2026 Aug 5 置信度 0.82
• Autologous platelet-rich plasma on endometrial growth and reproductive outcomes in women with thin endometrium: a multicentre cohort study.
  To evaluate the effect of intrauterine autologous platelet-rich plasma instillation on endometrial thickness and reproductive outcomes in women with thin endometrium undergoing embryo transfer.
  pubmed Alonso-Frías P, Francés-Herrero E, Agustina-Hernández M, Corpas N 等 2026 Aug 5 置信度 0.82
• Identifcation of extracellular matrix-associated signatures to establish a risk model in rheumatoid arthritis and osteoarthritis through transcriptomic analysis.
  Rheumatoid arthritis (RA) and osteoarthritis (OA) frequently coexist, complicating diagnosis and treatment. The extracellular matrix (ECM) serves as a critical modulator of disease progression, coordinating multilayered matrix degradation and inflammatory casc…
  pubmed Huang B, Huang Y, Lv R, Wang W 等 2026 Aug 5 置信度 0.82
• Gastric microbiota composition and its association with rescue eradication outcomes in refractory Helicobacter pylori infection.
  The relationship between gastric microbiota composition, Helicobacter pylori infection, and eradication outcomes remains unclear. This study aims to explore the association of gastric microbiota composition among patients with refractory H. pylori infection wi…
  pubmed Kuo CJ, Bui NN, Yeh YM, Lin CY 等 2026 Aug 5 置信度 0.82
• The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies.
  Agingis characterized by chronic low-grade inflammation ("inflammaging"), a key driver of functional decline and age-related diseases. The cGAS-STING pathway, which senses cytosolic DNA, has emerged as a central mediator of this sterile inflammation. Here, we …
  pubmed Wei Y, Cai S, Ji Y, Wang J 等 2026 Aug 5 置信度 0.82
• An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies.
  Therapeutic protein overexpression can overwhelm endoplasmic reticulum (ER) folding capacity, trigger unfolded protein response (UPR) signaling, and compromise the safety of gene and mRNA therapies. Here, we engineer stress-responsive RNA rheostats that couple…
  pubmed Ogurlu R, Sanchez EB, Hull JA, Fergione SM 等 2026 Aug 5 置信度 0.82
• Insulin gene-modified 3D stem cells for enhanced islet regeneration and systemic reversal of type 1 diabetes.
  Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic β cells, leading to lifelong insulin dependence and an increased risk of severe complications. Three-dimensional stem cells (3D SCs) culture systems have…
  pubmed Li Q, Ma X, Yuan K, Li J 等 2026 Jul 20 置信度 0.82
• Ghrelin and relamorelin counteract hypoglycemia in mice engrafted with congenital hyperinsulinism stem cell-derived islets.
  KATP-channel-related hyperinsulinism (KATPHI) is a rare genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycemia in neonates due to excessive insulin secretion. Management of the severe diffuse form of KATPHI currently lacks …
  pubmed Lithovius V, Montaser H, Saarimäki-Vire J, Ibrahim H 等 2026 Jul 20 置信度 0.82
• Mechanism of troxerutin-mediated regulation of EGLN3/LRPPRC in B[a]P-induced lung adenocarcinoma.
  Lung adenocarcinoma (LUAD) is the most prevalent and lethal subtype of lung cancer, exhibiting the highest incidence and mortality rates among all histological types. Although targeted therapy has shown promise, currently actionable genetic targets do not cove…
  pubmed Wu Y, Wang J, Xing Y, Gu Y 2026 Aug 5 置信度 0.82
• Litigating the hype: the Lung Health Institute class action and its implications.
  The recent Lung Institute class action lawsuit is used as an example of patient-initiated lawsuits regarding unproven "stem cell" interventions. Current regulatory considerations for administration and advertisement of cell therapies are contrasted to gaps tha…
  pubmed Alonzo M, Grilley BJ, Weiss DJ, Ikonomou L 2026 May 3 置信度 0.82