-
crossref
2002-09-17T18:31:03Z
置信度 0.70
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2021-10-13T22:20:25Z
置信度 0.70
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‘The future of genomics’ explores some of the ways in which genome science will continue to expand the frontiers of human knowledge, as well as change our world and the way we interact with it. Important ethical, legal, and social issues have already been rais…
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John Archibald
2018-03-22T11:03:18Z
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2002-09-17T18:31:03Z
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Xun Gu, Zhixi Su
2012-07-21T07:01:31Z
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2014-11-24T20:02:16Z
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2020-09-24T03:11:10Z
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Vincenza Maselli, Diego Di Bernardo, Sandro Banfi
2008-10-14T14:14:45Z
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Fintan R. Steele
2002-10-06T18:49:14Z
置信度 0.70
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John A. Stamatoyannopoulos
2004-07-08T03:50:17Z
置信度 0.70
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Together, molecular biology and genomics have made it possible to explore the diversity and ecology of the 99 per cent of microbes that cannot be cultured in laboratories. ‘Genomics and the microbial world’ considers environmental gene sequencing; metagenomics…
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John Archibald
2018-03-22T11:03:17Z
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2015-12-18T08:43:31Z
置信度 0.70
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Guoliang Xu, Colum Walsh
2014-10-22T18:28:59Z
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2016-08-16T09:19:20Z
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2012-07-30T09:42:30Z
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Jing Wu
2008-09-16T19:57:17Z
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2008-05-04T10:12:39Z
置信度 0.70
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Jennifer Pohlhaus, Robert M Cook-Deegan
2008-10-10T14:13:46Z
置信度 0.70
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Michael E Weale
2019-12-11T02:56:52Z
置信度 0.70
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2024-05-04T04:12:52Z
置信度 0.70
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2015-12-15T22:18:54Z
置信度 0.70
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Vasilis Vasiliou
2012-07-16T12:15:28Z
置信度 0.70
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2009-08-09T13:34:20Z
置信度 0.70
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crossref
Harald Brüssow
2018-03-14T10:03:09Z
置信度 0.70
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This chapter examines how genomics advances the understanding and treatment of human diseases by identifying genetic mutations, mapping disease-associated genes, and applying genome-wide association studies (GWAS). Mutations in specific genes cause inherited d…
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Arthur M. Lesk
2025-10-10T07:06:05Z
置信度 0.70
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crossref
Orli G. Bahcall
2021-10-13T22:20:19Z
置信度 0.70
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Boris A. Vinatzer, Caroline L. Monteil
2014-06-19T11:14:56Z
置信度 0.70
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Christine L. Carter, Anthony R. Kerlavage
2002-07-26T18:06:55Z
置信度 0.70
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Li Jin
2012-07-28T00:42:43Z
置信度 0.70
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2012-02-10T14:32:52Z
置信度 0.70
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Steven Cannon
2008-05-06T17:03:25Z
置信度 0.70
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Kevin Penn, Paul R Jensen
2012-03-08T08:14:15Z
置信度 0.70
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Jeanne L. Burton, Guilherme J. M. Rosa
2006-12-13T15:03:17Z
置信度 0.70
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Ch. Coutelle, A. Speer
2004-12-06T21:20:49Z
置信度 0.70
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crossref
2015-03-24T07:21:22Z
置信度 0.70
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Janet E Fulton
2009-07-14T18:16:03Z
置信度 0.70
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Zhanjiang Liu
2014-10-24T09:18:21Z
置信度 0.70
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A. Tsang
2014-11-19T05:44:56Z
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Edmund Maser
2012-12-01T17:14:22Z
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Peter Schattner
2008-12-06T10:25:30Z
置信度 0.70
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Lars Snipen, Trygve Almøy, David W Ussery
2009-08-19T14:14:15Z
置信度 0.70
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crossref
2002-10-07T10:19:13Z
置信度 0.70
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crossref
2002-10-06T20:18:03Z
置信度 0.70
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This chapter provides an overview of genomics, which is the study of the structure and function of genomes. A genome is the complete set of genetic instructions for an organism. Genomics is a huge area of study that encompasses many different (and sometimes co…
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Lia Chappell, Sarah J Lindsay, Phil Jones, Julian Parkhill 等
2023-09-15T07:24:37Z
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2016-06-29T10:31:41Z
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PY Kwok
2012-07-21T07:02:51Z
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2023-07-12T20:30:30Z
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2004-12-07T13:55:14Z
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crossref
David D Pollock
2012-07-28T06:34:31Z
置信度 0.70
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The integration of genomics into nutritional sciences has illuminated the complexity of genome responses to nutritional exposures while offering opportunities to increase the effectiveness of nutritional interventions, both clinical and population based. Nutri…
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Patrick J. Stover
2004-01-30T20:05:02Z
置信度 0.70
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Vasilis Vasiliou, Daniel W Nebert
2012-07-05T16:30:47Z
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J. Mark Petrash, Philip A. Ruzycki, Gregory J. Zablocki
2019-12-10T21:30:22Z
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Argentina’s population numbers about 40 million, with main genetic contributions from Europeans, Amerindians and, to a much lower extent, West Africans. There is a traditional health care system publicly funded coexisting with a social security system and a fo…
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V.B. Penchaszadeh
2008-09-11T10:20:01Z
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Katina Lazarow, Stephanie Lütticke
2009-01-29T19:18:09Z
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This chapter explores the incredible advances which have taken place—and are still taking place—in the technologies involved in DNA sequencing and in DNA manipulation. The invention of DNA sequencing technology enabled DNA to be read for the first time in the …
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Lia Chappell, Sarah J Lindsay, Phil Jones, Julian Parkhill 等
2023-09-15T08:21:46Z
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Clint Magill
2012-10-23T08:59:24Z
置信度 0.70
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Vasilis Vasiliou
2024-01-02T05:42:40Z
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crossref
2002-10-06T19:13:49Z
置信度 0.70
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Abstract The sequencing of ancient DNA from preserved biological remains is producing a rich record of past genetic diversity in humans and other species. However, unless the primary data is made available in public archives in an appropriate fashion, its long…
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Anders Bergström
2023-05-17T01:10:17Z
置信度 0.70
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David Schlessinger, Minoru S.H. Ko
2002-10-06T23:06:27Z
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Andrew Chaulk, Nusha Keyghobadi
2022-12-02T06:54:54Z
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L. Z. Holland
2012-03-23T10:43:58Z
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crossref
2025-10-22T08:13:47Z
置信度 0.70
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Dysregulation of lipid metabolism has been implicated in Parkinson's disease (PD), yet causal relationships remain unclear due to confounding factors inherent in observational studies. Most Mendelian randomization studies on lipid-PD relationships have been co…
pubmed
Bao Y, Huang H, Feng W, Li F 等
2026
置信度 0.82
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Gliomas are the most common primary brain tumours in adults, characterised by significant cellular and molecular heterogeneity. Recent advances in molecular profiling have transformed brain tumour classification but, despite these developments, gliomas remain …
pubmed
Kinsela B, Zaytseva O, Muckle D, Bonello TT 等
2026
置信度 0.82
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Pharmacogenomic (PGx) variation is an important determinant of inter-individual variability in drug response. While germline pharmacogenomics has been extensively studied, somatic alterations affecting these pharmacogenes in tumors remain less systematically c…
pubmed
AlMulla A, Kaur S, Balyan P, Al-Saafin S 等
2026
置信度 0.82
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Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a high-risk subtype of T-cell acute lymphoblastic leukemia (T-ALL). Aberrant CD19 expression in ETP-ALL may lead to misdiagnosis of mixed-phenotype acute leukemia. Notably, nucleophosmin 1 (NPM1)…
pubmed
Lu Y, Chen Y, Zhang Q, Wu G
2026
置信度 0.82
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Inborn errors of immunity are rare, genetically heterogeneous disorders requiring coordinated clinical, laboratory, and genetic evaluation over time. Data are often fragmented across records, laboratory systems, and genomic reports, limiting longitudinal analy…
pubmed
Ahmed M, Bousfiha AA, Almarzooqi F
2026
置信度 0.82
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Duolang sheep is a meat-fat dual-purpose breed originating from Xinjiang, China, and the genetic basis of body size variation in this breed remains unclear.
pubmed
Wang K, Niu Z, Tang S, Han B 等
2026
置信度 0.82
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Despite major advances in high-throughput genomics, proteomics, and multimodal imaging, a substantial gap persists between molecular tumor characterization and clinically actionable therapeutic decision-making, partly due to the limitations of conventional pre…
pubmed
Caruso A, Delvecchio A, Memeo R, Lanzino M 等
2026
置信度 0.82
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Congenital intracranial-extracranial communicating mixed germ cell tumors (MGCTs) are extremely rare in infants, with no standardized treatment protocol. We report a 2-month-old female infant with giant congenital intracranial-extracranial communicating MGCT a…
pubmed
Shi Y, Wang C, Liu Y
2026
置信度 0.82
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Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with an elusive pathophysiology. Although immune dysregulation and mild mucosal inflammation are recognized as important factors in IBS, the specific contribution of immunosenes…
pubmed
Yao Y, Li J, Zhang B, Li T 等
2026
置信度 0.82
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Neuroblastoma is the most frequent extracranial solid tumor of young children and demonstrates a wide range of biological behavior, from spontaneous regression to highly aggressive metastatic disease. Recent advances in genomics, epigenetics, tumor microenviro…
pubmed
Singh A, Goel N, Mehndiratta S, Chaudhry A 等
2026
置信度 0.82
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Precocious puberty (PP) is a pediatric endocrine disorder. Bisphenol A (BPA) is an endocrine disruptor. This study aimed to computationally investigate BPA-associated PP targets and mechanisms via network toxicology and molecular dynamics.
pubmed
Nie R, Huang F, Zhan Y, Li L 等
2026
置信度 0.82
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Salmonella is a major foodborne pathogen, and eggs are established vehicles for common serotypes such as Enteritidis. However, rare serotypes like Braenderup are infrequently identified in outbreaks, partly due to limited routine surveillance and the low resol…
pubmed
Ao H, Huang Z, Liu J, Huang T 等
2026 Jul 24
置信度 0.82
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Following the recent global progress in the establishment of soybean genomic resources, DNA marker technologies have been actively implemented in soybean breeding programs in Japan, thereby enhancing the efficiency of varietal improvement and facilitating the …
pubmed
Kato S, Yamaguchi N, Kaga A
2026 Mar
置信度 0.82
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Genetic information is a special category of personal data that is relevant for its predictive reach. The purpose of this paper is to provide an overview of the state of the art on the communication of genetic test results in both clinical and judicial practic…
pubmed
Di Lorenzo P, Marisei M, Macculi M, Casella C 等
2026
置信度 0.82
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Tomato plants are susceptible to a wide range of viruses, including those belonging to the genus Tobamovirus , which pose enormous threats to tomato cultivation worldwide. This article reviews a genomics-based breeding strategy applied for the rapid discovery …
pubmed
Verweij W, de la Fuente van Bentem S, Ykema M, Perefarres F 等
2026 Mar
置信度 0.82
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Human infections with influenza A(H1N2)v viruses of swine origin have been sporadically reported in several countries, usually following direct or indirect exposure to pigs or contaminated environments. However, sustained human-to-human transmission has not ye…
pubmed
Chen L, Chen Y, Han X, Ni R 等
2026 Jul 17
置信度 0.82
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This is the first report of Corynebacterium belfantii ( C. belfantii ) in Fujian; genomic characterization confirms misidentification by routine methods and reveals regional phylogenetic characteristics.
pubmed
Wu W, Deng Y, Jin R, Mao J 等
2026 Jul 17
置信度 0.82
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Climate change and intensifying disease pressure push viticulture beyond incremental adaptation, especially where grape production depends on repeated pesticide applications. Reducing chemical inputs requires an integrated strategy combining broader genetic di…
pubmed
Gambino G, Agnoli L, Chitarra W, Dressler M 等
2026
置信度 0.82
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Phthalates (PAEs) are ubiquitous endocrine-disrupting chemicals (EDCs) with well-documented prenatal effects, while their impact during early postnatal life remains less understood. Minipuberty, a transient activation of the hypothalamic-pituitary-gonadal (HPG…
pubmed
Trevisani V, Lucaccioni L, Starace F, Passini E 等
2026
置信度 0.82
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Osteosarcoma (OS) is an aggressive primary bone malignancy characterized by high metastatic potential and limited therapeutic progress. Beyond genomic instability, accumulating evidence indicates that OS operates as a communication-driven disease in which dyna…
pubmed
Ricciardi G, Fiorentino V, Tralongo P, Lentini M 等
2026
置信度 0.82
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Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality worldwide, yet the associations linking alcohol-induced gut microbial alterations to metabolic remodeling and hepatocyte dysfunction remain incompletely understood. H…
pubmed
Ding R, Qi F, Dai Q, Li K 等
2026
置信度 0.82
-
Tea, made from the tea plant ( Camellia sinensis L.), is one of the most widely consumed beverages worldwide. Traditional breeding methods have contributed to the development of cultivars with desirable traits; however, these breeding approaches are time-consu…
pubmed
Ishiguro Y, Yamashita H, Ikka T
2026 Mar
置信度 0.82
-
The development of new cultivars exhibiting high levels of disease resistance and superior quality is critical for vegetable production. Recent advances in genomics and DNA sequencing technologies have facilitated the identification of sequence variants associ…
pubmed
Nunome T, Kawasaki M, Kakizaki T, Miyatake K 等
2026 Mar
置信度 0.82
-
'Harushizuka' is a novel late-maturing satsuma mandarin ( Citrus unshiu Marcow.) cultivar developed through heavy-ion irradiation-induced mutagenesis. The S1152 line, selected from a nucellar seedling of the 'Aoshima unshu' cultivar for superior fruit quality,…
pubmed
Ishii K, Okubo T, Shirakawa Y, Tomura K 等
2026 Mar
置信度 0.82
-
The National Agriculture and Food Research Organization (NARO) is advancing "Citrus Breeding 2.0" to produce diverse, high-quality hybrid citrus cultivars more efficiently by integrating genomic prediction, genome-wide association studies (GWAS), and pedigree …
pubmed
Shimizu T, Nonaka K
2026 Mar
置信度 0.82
-
In response to recent environmental and geopolitical changes, Japan requires rice cultivars with high adaptability and production efficiency. Advances in rice genomics have enabled precise genetic mapping and the use of DNA markers for efficient selection. Mar…
pubmed
Goto A, Matsushita K, Yamanouchi U
2026 Mar
置信度 0.82
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This review summarizes the current status and future prospects of using genomic information for wheat breeding. Wheat has the largest genome among all major crops (~16 Gb), thus requiring a sophisticated approach to collect and utilize genomic information comp…
pubmed
Tanaka T, Kobayashi F, Ishikawa G
2026 Mar
置信度 0.82
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The lung vasculature is comprised of a series of branching vessels extending from the main pulmonary artery to the alveolar capillaries, then back to the pulmonary veins. Lung endothelial cells (EC) exist along this continuum, exposed to gradients of shear str…
pubmed
Sveiven SN, Knutsen C, Zanini F, Cornfield DN 等
2026 Aug 6
置信度 0.82
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pubmed
Papathomas T, Andreassen M, Farkas L, Lund-Iversen M 等
2026 Aug 6
置信度 0.82
-
BackgroundThe SLC25A46 gene encodes a mitochondrial carrier protein previously implicated in neuropathy and optic atrophy. Biallelic variants in SLC25A46 have been described in patients with Parkinson's disease (PD) with optic atrophy, but the evidence support…
pubmed
Yu H, Parlar SC, Senkevich K, Somerville EN 等
2026 Aug 6
置信度 0.82
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T cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. While transcriptional, epigenetic, and metabolic rewiring have been well…
pubmed
Pledger ES, Ambavaram N, Ferguson L, Cate JHD
2026 Aug 6
置信度 0.82
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We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs).
pubmed
Olayinka O, Farrell JJ, Zhu C, Khurshid Z 等
2026 Aug
置信度 0.82
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Fungi can oxidise pyrite, a process which has potential implications for metal bioleaching and acid mine drainage formation. However, this capacity has been demonstrated primarily using only a few model fungal strains. Diverse fungal communities are known to i…
pubmed
Li YX, Li YY, Luo XL, Wu GX 等
2026 Aug
置信度 0.82
-
Whole-exome sequencing (WES) is increasingly used in pediatric diagnostics, yet families often struggle to understand its complexity and implications. Educational resources that facilitate informed decision-making are essential in genomic medicine. This study …
pubmed
Harada K, Kaneko M, Kosugi S, Kawame H
2026 Jan-Dec
置信度 0.82
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Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, radiology, genomics, and laboratory medicine, into a coordinated framework designed to improve diagnostic accuracy, treatme…
pubmed
Lennerz JK, Del Ben F, Stenzinger A, Frauenknecht KBM 等
2026 Aug 7
置信度 0.82
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Programmable large-fragment genome integration using prime-editing-coupled serine integrases, such as PASTE and PASSIGE, remains constrained by the limited activity of wild-type Bxb1 (WT Bxb1) in mammalian cells. Recently, the AI-guided protein engineering fra…
pubmed
Sun YD, Song LJ, Liu B, Cheng CY 等
2026 Aug 6
置信度 0.82
-
Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood-brain barrier (BBB) disruptio…
pubmed
Acharya A, Thurman M, Sutar D, Olasunkanmi OI 等
2026 Aug
置信度 0.82